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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX2</accession>
    <name>D4CYX2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025806.1">
        <property type="nucleotide sequence ID" value="XM_003025760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYX2"/>
    <dbReference type="GeneID" id="9582049"/>
    <dbReference type="KEGG" id="tve:TRV_00009"/>
    <dbReference type="HOGENOM" id="CLU_2293745_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="101" mass="11492" checksum="A4D89C5BAE3F7254" modified="2010-05-18" version="1">MSTAVLLHDRLGPGKASFLLQTKTRRRSRKEEQEQQTQKKQNRDSERGRDSEKGGGYLGYLEPYPRAMGGRGTSKDRAAGRTAQQRQGKAKKKKTTREKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ16</accession>
    <name>D4CZ16_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025791.1">
        <property type="nucleotide sequence ID" value="XM_003025745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ16"/>
    <dbReference type="GeneID" id="9582034"/>
    <dbReference type="KEGG" id="tve:TRV_00053"/>
    <dbReference type="HOGENOM" id="CLU_1220457_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26109" checksum="EB51443F57118CF7" modified="2010-05-18" version="1">MSTASWALGKVGITCLRTARSSTIPNFARIKLYIFTDRLIEYWDPILKEPYVKNLSQGLCLEKSDRNIKNEANALLAVKKITTINAPRLIDFVTIDATRAAQLVTIDFQENPEALLISEFIDCLTRGVTKSRNEPPLSLLYERKYDLCFTPLDLHRSNLFVTRGRLSGIIGWKNAGFKPEYWEFTRSLWPYGGERKLCYIHTYAFDGKYDDELEAEVSILYNSPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ69</accession>
    <name>D4CZ69_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025692.1">
        <property type="nucleotide sequence ID" value="XM_003025646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ69"/>
    <dbReference type="GeneID" id="9581940"/>
    <dbReference type="KEGG" id="tve:TRV_00106"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="4173553at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="528" mass="57168" checksum="D568EF2239F762F6" modified="2010-05-18" version="1">MWEPQKKSPKRPVELADTSIAMKPSTIGDRVRFFGLVAVLFFSIFLTFLEAAILAALAPQISSNFNDTEHAGWYNYAYILTFASLQPSWGKIYRCFSLKPAFLISFLILGLGSIICGTAATPKTFIAGRAISGVAGGGLITGAYTVVGHTIKNGRRRPLYIGILGAAYGTSNIAGAYIGTLFLGSVSYRWIFYTNTAIGSLCFIALLFCFAIVPTVIPLPVSRKEMFLLLDLPGLVTIWPAMVCYVISMQSRKTTDLWSDTITTVTRFAFGVLLVIFFLSQWWSGKYANIKLRLFATRDTAVCTAFTFFLAGALATHLYILPTYAQALDGASVPESRIRMMPLMIAISSSSILSGYLIGKFGYYTPMLVIGGIFTIIGTGILYTLDAATTPYKCATFQVITGIGIGAACQVPIIVNMSLVEIEDLPTIITATFFLQSLGGFFLNQASQAAFIGKIRKLTATSTDPKVVTVIQLSATSLRDEFTGESLKLVLNAYHGGIEIVSIIGIVAASMALILSISPQWKKLSEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZD3</accession>
    <name>D4CZD3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025652.1">
        <property type="nucleotide sequence ID" value="XM_003025606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZD3"/>
    <dbReference type="GeneID" id="9581891"/>
    <dbReference type="KEGG" id="tve:TRV_00175"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="64"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="372" mass="40027" checksum="C2CDE8A4B9359708" modified="2010-05-18" version="1">MTDKQHWLPVTRENIQTAHSMIRPYIYETPVLTSKTLNSLASTPQPAEALIGTPFEGQQPACPKIKFFFKCENFQRIGAFKVRGAFHSILRVIKTKGEEEAVALAASTLSIPAYIIMPSISIPSKIEATKGYGGKVVFSGLTSEQREEVMRKVQEETGAILIHPYDHPDTIIGQGTAGLELDTQVNKLVSENPELSVRETEDGKGCGLDAVITPVGGGGLNSGTATVFADPRADGRKIHVFGAEPSFQGADDARRGLKAGVRIPEVKSLTIADGLRVPIGEIAFSILSDPAKSRGVFSVTEEQIKSAMRLVVERMKIVIEPSAAVPLAVCLYNEEFRRIVEQEGGEAGWNIGVIFSGGNTTIDAMSGLFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZM4</accession>
    <name>D4CZM4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025504.1">
        <property type="nucleotide sequence ID" value="XM_003025458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZM4"/>
    <dbReference type="GeneID" id="9581741"/>
    <dbReference type="KEGG" id="tve:TRV_00266"/>
    <dbReference type="HOGENOM" id="CLU_067402_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="38277" checksum="A5D7F168BF1018F9" modified="2010-05-18" version="1">MLKRRAKLKRLSLDDRERVLKSRALPDDFDMAQSLQSSYATEHHGYTTPLVSPGTFFPPEENDPYGSARAGTAAADDYTTSPLSSTSAYGSYFGRDSSAYSRGSDSISSMSTSSDSIGSFGSMPSANPSIHGRMNFVPRSFGEQQGAMRPSVPQLHMYNTSLRARAGSLNLPMRGTIPCHTPPLEYTDTDSSTNINNAYGSRSLDASTRRDPFGLGSVAEEFKQKTVGQPVTATPRIGEGSPPKADHSRAAAVALQSAPLQSTQEEDQLSGLGPQFNLSSFGITYPRQSPSTSPNHPTSHPSSKSSDMQGAYNNHGTAWLQQTIQQKLSCYPEPDYSAPRQRGYFYQSNTETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY8</accession>
    <name>D4CZY8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asp/Glu racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025442.1">
        <property type="nucleotide sequence ID" value="XM_003025396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY8"/>
    <dbReference type="GeneID" id="9581668"/>
    <dbReference type="KEGG" id="tve:TRV_00382"/>
    <dbReference type="HOGENOM" id="CLU_053002_0_0_1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28691" checksum="3FF9F828AE4F4AE2" modified="2010-05-18" version="1">MQLISAEYPTSSLKLPVENDCQVGGYSSLAGQAQTDSTPVDLSSEELEGLCKNGITCSVVNLNTGPISVESRTDKALAIPGLIAAAQREAQKGADAIVIDCFGDPGLDTLREVVDIPVLGVAQISMNICASLADTFGVVTILKESIPIIKDSVKAYGHEGRFVGCNAIDMRSLEIKGEVNEMTNRLAEHALALVREKGAHSIILGCTGFIGCAEEIKKRLELSGLDVPVVDPMPATVFSAIPLLRLGLRQSRESYPRSTIKETKGYIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D077</accession>
    <name>D4D077_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025410.1">
        <property type="nucleotide sequence ID" value="XM_003025364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D077"/>
    <dbReference type="GeneID" id="9581646"/>
    <dbReference type="KEGG" id="tve:TRV_00471"/>
    <dbReference type="HOGENOM" id="CLU_041459_0_0_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="546" mass="60192" checksum="81B9F350C6B1AD37" modified="2010-05-18" version="1">MVSILYSERIFPRTKQDSEETIALSLLDATTVHFAHTCSTWLCEAPETAAGPEFDLADHLRQSLRVVLDAYPQWCGRINAITTLDGAAGPHTQRFGRVYVQYGTPQDPGVEFRVAETTATLDTVCPALRTVDQPVWNRQEIPPEKFVPSTALSNALQPDILDDAGLLPPLLAIQLTNLACGGFILTVKIVHPLADIQSLVYFVKDWASVSRSVLSNTPCPTLNPLFEPGLLDSLAAGDIDAVEPDMAIIQRAKSMPLHRYDWWASSPNSPWPVKVPEALAGKMLSPAGKPMPWSEWNITEPVSHYVVHLNRHQVEAILKGATCGLSRDMGPTRISQHDAILAHVWSCINRARNLEEDSQPVHCDLVYGVRPAFKLDKSFLGSPMLMINVEMSSADVTAGSRPCNIPALQSIAQRIRQTIGEVSQPDLLAAHLHSVAYEESPQRIWQAFLGRRHILVTSWARAGLYEIDFGLGSSPIIRYADSFIPDMDGTIVIKEAPPLKKEDTSDGSLPSSWTANGVDISLRLRSEDMDRLLSDSMLFPQNTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0W7</accession>
    <name>D4D0W7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025055.1">
        <property type="nucleotide sequence ID" value="XM_003025009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0W7"/>
    <dbReference type="GeneID" id="9580567"/>
    <dbReference type="KEGG" id="tve:TRV_00713"/>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="136" mass="15395" checksum="AD61B32AEA35652A" modified="2010-05-18" version="1">MKILASNFVTCAVKACKSSSASYPLHFRNAELEEEELDFQPDFIRNILPRIDWVALKISASELGFPSISESKPEGEELNNEQLLRDLHKLLLETHVVEGELVCGNCGHEYKIKEGIANFLLPSHLDGYTRDTSTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1C2</accession>
    <name>D4D1C2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane associated DnaJ chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024951.1">
        <property type="nucleotide sequence ID" value="XM_003024905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1C2"/>
    <dbReference type="GeneID" id="9580443"/>
    <dbReference type="KEGG" id="tve:TRV_00872"/>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="41498" checksum="77F8035A61AC27C7" modified="2010-05-18" version="1">MDAASRVLSYAGWAFLPGNLYYRITISAGTPHPQPGSERHARHRRRIHVAVISSYLLYTIYEEYHSLRVAPDFYQILGVLPTSDERTIKSRFRRLATVFHPDKARQNGLGSTAEDGAKADEFFVLLKLAQDTLLDPVKRFAYDRFGAGVVVRPEGPSKTLSMATYFYEGLYALAPQYLVGFLLMVLLNTFWFSAWGRYWRFYTFFALLTLELTLLTHPNATFMPGAYLPAMLSNLLGLDRFYLLPFQMLSLARTASMSMNVFISQLAPPEATLQASRSKGRGGGGEGLSVQAQKQLTQIVQLAQAQDAESAKLLGMDMLPFRGDVDRVGRLRRGMKERLRREEAGQAPEVQQAIAAVKQGRQQGRNEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1C9</accession>
    <name>D4D1C9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024958.1">
        <property type="nucleotide sequence ID" value="XM_003024912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1C9"/>
    <dbReference type="GeneID" id="9580450"/>
    <dbReference type="KEGG" id="tve:TRV_00879"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="350" mass="38919" checksum="2F5F30478531DB54" modified="2010-05-18" version="1">MSNQFAPLKNDLLLRAARAGRYLPEYHEAKGDRDFFECCRSPEVASTLTLQPIERYAGLIDAAIIFSDILVIPQAMGMEVEMIDKKGPSFPSPLRTPEDEQYTQVLNRTVDVTTELDYVYKAITLTRQKLEGRVPLIGFVGAPWTLLCYMVEGGGSKMFAAIKTWIYKYPDASKKLLQKISEVCVEHLAQQVKAGAQMIQVFDSWAGELSPRSFAEFSLPYLRYVSANLPKRLQEMGLEVVPMTVFAKGAWYALDELCESGYNVVGLDWQHDAAKARAVANGRVVLQGNADPGCLYGTREGITAVVEEMVKGFGGGKQGWIANLGHGVTPFVKPDDLKFYFEEIHRLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1G3</accession>
    <name>D4D1G3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00913</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024908.1">
        <property type="nucleotide sequence ID" value="XM_003024862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580399"/>
    <dbReference type="KEGG" id="tve:TRV_00913"/>
    <dbReference type="HOGENOM" id="CLU_000487_2_4_1"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="327"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1303"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1642" mass="182533" checksum="41030CE4E29666C3" modified="2010-05-18" version="1">MSSFAIPVSSSIGGIDFGVMSDEEIKAVSVKRIYNTPSLDSFNNPIPGGLYDAALGAWGDHISQCIYCHRFRMSRAQVNTYSCKLRLLQYGLIEEAHIVGNMELRKGARGKDDSSDDDSDDEDDVSLIQRRNAYVKRCIANLPVHKRSRSHMEIVKDPTAAEMRRSLVRDFLREACAVKKCTSCSGISPAYRRDKYSKIFRKSLPQKARIAMMEAGFQIPNPLVLMEEASRLSQKQKDGDKTANLTESLDDDDQPNAEQQISVGNTMLMDVEEDAMTQVGDIESQQYVPSSEIYASLHFLFNKEQEILDLIYDSRPFVKKRSHISANMFFIKNILVPPNKFRPAAQQGPNEIMEAQQNTSFGRIIKLCDQINQISRERQGDTTGTSRRIRDYRDLLQAIVQLQDAVNSLIDRDRNPSQGLGAQNEDGIKQRLEKKDGLFRKNMMGKRVNFAARSVISPDPNIETNEIGIPLVFAKKLTYPEPVTNHNYWELKQAVINGPDIYPGAAAVENELGQVVSLKFKTVDERVAIANLLLSPSNWKLKRSRNKRVYRHLTTGDVVLMNRQPTLHKPSIMGHRARVLTGERTIRMHYANCNTYNADFDGDEMNMHFPQNEIARAEAMQLADTDHQYLVATSGKPLRGLIQDHLSMGVWLTCRDSFFDEDDYHQLLYSCLRPENSHTVSDKIWLMPPAIFKPQPLWTGKQIISTVLKNITPDNRAGLNLDSKSSTPGDRWGDKAEGEVTVRDGELISGILDKSQLGPTVGGLIHSIHEVYGHIVAGKLIGILGRLLTKVLHMRAFTCGMDDLRLTEEGNAKRKELIQQADGLGKEISLKYVTLDENKVDDEDTELQRRLEEVLRDDDKHAGLDAMYKSRAGELSSEITKACLPSGLEKPFPFNNMQTMTVSGAKGSMVNANLISCNLGQQVLEGRRVPVMISGKTLPSFQPFETKIGAGGYVFGRFLTGIKPHEYYFHAMAGREGLIDTAVKTSRSGYLQRCLIKGMEGLKAEYDTSVRDTSDGSIVQFLYGEDGLDITKQKHLDSFSFLAQNYMSIVSQVNGVNDSSKIHSEEASSWSKAALKKIKKTGKIEAKDPALAHFPPGANYGSTSEKFSSALKKYLKSNPDNLLKDKSTGEGEITKKAFTTMMNMKYMKSVIDPGEAIGIVAGQSVGEPSTQMTLNTFHLAGHAAKNVTLGIPRLREIVMTASSHIMTPTMTLKLNKQTDEKTARLFAKTITKLTLAEVVDKLKVRERVTSQGSAKAKIYDIQIDFFPPEAYCAEYAIQVNDVLRTLEEKFIPRLVKLTEAELKKRTSEKSLSSPSAAQPEIGTSVGVVEEARREGGDNDEDDDEDLDDAKRASSSRNNAGQASYEAPDEGEQEIIRRQDTPDLESDDEDTDDKQKLAPVDNSDSDTDMEDPVPSKARKLANSRDRADTLRGKYPALTQFKFDPENGSLCTIQLQYDISTPKLLLLPLVENAARTSVIQFIPGLGSCAYIPADKGEPEHVVTEGVNLLAMRDYQDIIDPHSIYSNSVSHMLGLYGVEAARATIVSEVGAVFEGHGIKVDNRHLTLIADVMTQTGGYRAFNRMGIVKDSTSPLMKMSFETTVRFLRDAVLERDWDNLNGPSSRIVVGRVGTVGTGAFDVLAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1I5</accession>
    <name>D4D1I5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetyl-CoA synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024930.1">
        <property type="nucleotide sequence ID" value="XM_003024884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1I5"/>
    <dbReference type="GeneID" id="9580421"/>
    <dbReference type="KEGG" id="tve:TRV_00936"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_7_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22052" checksum="3A1D5B37CB59219D" modified="2010-05-18" version="1">MPVFLWGDKDNKKYNSSYFERYEHICVWAQHDWISVNPVTKGISMHGRSDGVLNPSGIRFGSAEIYAISEGPQFNTEIENTLCVGRRRVKDKDEEVFLFVKMRNQAQNRLTPELEQRLRLAIRTSLSARHVPKFIVQVPEIPMTINGKKVEIAVKKIISGNKVQVSATVVNPKALEFYEQFYELEAQPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1P8</accession>
    <name>D4D1P8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024826.1">
        <property type="nucleotide sequence ID" value="XM_003024780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1P8"/>
    <dbReference type="GeneID" id="9580335"/>
    <dbReference type="KEGG" id="tve:TRV_00991"/>
    <dbReference type="HOGENOM" id="CLU_017097_0_0_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="778" mass="86830" checksum="42C5629211F79775" modified="2010-05-18" version="1">MVLSLLSNKTPRNNKRTPAPLSSSGPPSTASSSSRSIKVVSPATAITVKLSPTASSTLAEALRSDPFAPGSQSNTNTTTTTTTTTTPAADILTGSHDTEDENHRELRERNEALNVLARIFPDIHPEVFRELLTRFDGKSRLEVSVEQLLRYRSEWVKGRWNVSSASGGTGTLSTTEGGPDARNKPVPREELFRSDQYKDAARAALAAEFRSLSRSTIDAVLAEGNFSYVRARPTLLDLSRKSWRVTLGNMFSFKKKKAPHKNDPPPYLVWQRSSTDEPEPVLRSTGCAELDEEIHSTYLLPLVKQRRETQVEEDFRKAEDLNEVEAKVVDALYECDCCLSDVTFEQISTCSEACHVICFNCIQRTLQEALFGQGWDKSISSEKSTLWCIAPFANGTCQGTLDAELVKRAILKERSGMETYRKFEARLASESLAKSNLKLIHCPFCSYAEVDPVFHPSVQGITWQFRKASLATSIAVSILLLDIFQFFLLPLLLLLCISPSALRTIFHRSLQNICLRRRSPRFKCGNPTCSRASCMRCHKAWNDPHTCHEPLLQSLRTTVEAARTAAIKRTCPCCGLSFVKASGCNKLTCVCGYSMCYICRKALGPKRRQQSNGRNNDGGGGIQLLDGAANAESDNDEIGEEAEGYKHFCEHFRIVPGSACTECNKCGLYQTEDEEAVAQRAGEQAQREWRIQQGMEVNTEDTRTTGAAVTSHKRNPTGATPKMARVYDWDLQFDVTSGSRRFGWEFWTKYLWQNQRWKMEIQLLVDNAIDTLVVVDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1V0</accession>
    <name>D4D1V0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">TRV_01052</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024770.1">
        <property type="nucleotide sequence ID" value="XM_003024724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1V0"/>
    <dbReference type="GeneID" id="9580260"/>
    <dbReference type="KEGG" id="tve:TRV_01052"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="1"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="925" mass="102880" checksum="96951AA11AAE39EB" modified="2010-05-18" version="1">MAASTSSQPPAGQQTVEWPALRVRDTFLDYFKKNGHTFGTVDPNSDFAQLKRAHNSQKDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAIQFSWELLTKVYGLDPDRLYVTYFEGNEAAGVGPDIEARDIWRSVGVKDDHILTGDMKDNFWEMGDQGPCGPCSEIHYDRIGGRNAAHLVNQDDPDVLEIWNNVFIQYNREPDRSLRPLPNQHVDTGLGYERLVSILQNKSSNYDTDVFTPLFNAIQNITGARPYTGKFGAEDADGIDTAYRVVADHLRTLTFAITDGAAPNNEGRGYVVRRVLRRGVRYARKYLQVEIGSFFSKLVPALVEQMGDMFPEIKRKQTDVMEILDEEEVSFAKTLDRGERQFENYAQQALDSGAGKLPGADVWRLYDTFGFPVDLTRLMAEERQLTIDDAEFEEARLKAKEASKGQAKTASDLLKLTVHTLSTLEKNGVPKTDDDAKFGKGNIVANIKAICHGKDVIDSTKDIPANEQIGIILDKTNFYAEQGGQEYDTGKIVIDGQAELDVQNVQMYGGYVLHTGFIKYGNFSVNDSVIAEYDELRRWPIRNNHTGTHILNFALREVLGDGIDQKGSLVAAEKLRFDFSHKSAISDSDLEKIEAKSTDYIRQNCAVYSQEVPLATAREITGVRAVFGETYPDPVRVVSVGVELDEILKNVKDPRWEGVSIEFCGGTHVQKTGDIKDLVILEESGIAKGIRRIIAVTGEDAHEVQRVAREFGERLNRFEKMPAGPERDAEIKSLQVDLNQLTISAVEKTKYRNQFTQIHKKITDAQKAAQKAEVKTAIDAISAYFEENKDSPSLVIKLPITANQKAISESLNHVKTKLSGKALYVFAADASKVAHGCYVTPDLTTKGASANEWASAVSSIIGGKAGGKAPVAIGNGTEVNKVDEALDEATKYLEKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A2</accession>
    <name>D4D2A2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024637.1">
        <property type="nucleotide sequence ID" value="XM_003024591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A2"/>
    <dbReference type="GeneID" id="9582811"/>
    <dbReference type="KEGG" id="tve:TRV_01206"/>
    <dbReference type="HOGENOM" id="CLU_310609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="947" mass="107050" checksum="5F46F8F4079855F1" modified="2010-05-18" version="1">MMNIFGLNGHASPDNPDIGWAGIDVPEYSKPYLNTLSALRDAVRRLTKSNAHITSQTLGSIINTIGSSADLGHSMSDLALPYVEVLRKFKDQIASLNLGTTEVDPNQLLSGCAIIRPVTSDLIKTRQGQTERKLQAQKRKVEEGRKQAEKMEKGRLSPYEMFRTDEFTAWDQDGVPTKDSEGKDLSKTRVKKLRKDWERKKKLQEAWMSAASKPTHDLFSYTSGRFLYNESARLRERYVEFDVTALKEAVTKHTGAKVTNLAKLGEGGFNRVLNATLENGLQLVVKIPYPLSVPRKYATASEVATLTFLRSKGIPVPKVYGWSATDENAVGAEYVIMELASGIGLDTRWFSMTKKQQQTVALGIVGIEKTLFDIPFGSIGSLYFKEDLPLELQHNLYLPGASDPDGDCNTFCIGPIADYMFWYGKRSELKLDRGPWSDPCQYLRAIGNRELEWTKKYGNPLEKEFPYNTLLPGTIPHEKYAALLEKYLAIAPFFLPKDPLDPGNQPTIRHPGIADLTPANVIVSPDTFDITCIIDWQHAVITPLLLAAGHPKMFENPDVEPPETLEVPKPPEGYDTLDIETKSQVDELLRRRYLHYLYRVFNGARNKSHLSAFYDPVLQPRQHLVDHAGRQWSGNIITLRGALMRMCGYWPLLSTKEECPISFTDAELKKHSEDEAMWFDLTALVHYWRDELGGLSEEGWIRSEMFDHAMKRNKELQEKFINDADPDEVEMVEANVQINYRREKLNIWFKEKAQASRGRGEPFFYISCDMVIMELTTPRAFPGSKGEMEGLRVVVAYVVLFRTSVVVGAHGTAMLDTGRRGNELYDGPKAECRHCIFRTPPNPRAQTQDMRKTVRHRDVTVTNGVLGYAHNCSVWTQEHLMPCEQRNLQLEELNLLILFLVTVMMVAKGPKEQGCEQKLIYFPQGNLGQLGPKAVSAAAASEYWKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2F7</accession>
    <name>D4D2F7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024550.1">
        <property type="nucleotide sequence ID" value="XM_003024504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2F7"/>
    <dbReference type="GeneID" id="9579773"/>
    <dbReference type="KEGG" id="tve:TRV_01262"/>
    <dbReference type="HOGENOM" id="CLU_067218_1_1_1"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="216" mass="23954" checksum="7F21846EEF7E8248" modified="2010-05-18" version="1">MVSSRAATRLLAYRAPSPLTPAYASSVVRASTSSFSTSAIRAATPAGPPPSGFRLAPPKRWDQQGETSLDSATKYFLMAELFRGIYTIFYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERVDGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAARADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2R2</accession>
    <name>D4D2R2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000075">
        <property type="protein sequence ID" value="EFE43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024474.1">
        <property type="nucleotide sequence ID" value="XM_003024428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2R2"/>
    <dbReference type="GeneID" id="9579694"/>
    <dbReference type="KEGG" id="tve:TRV_01368"/>
    <dbReference type="HOGENOM" id="CLU_035339_0_1_1"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="529" mass="60036" checksum="E359B7E4BF7CD95D" modified="2010-05-18" version="1">MEMEPKLPTAQHKKQAMADKAEPPGYDMIAHAESQLIVSKASRVQRRILRKQGLISHSHVEIVWWKREEGAVNNRSSAVTGPALFLAPMLAHLGASLGKKVFEGEGESFHSLSSTPPTPINNTTITTPRSLTASSLEKLKMNDSPIKPLKLDHADKENVPVSSHVAEPELKKVEIEASKPAETQVVKPKTPKELEAEEPLLQENPQRFVLFPIKYREIWQMYKKAEASFWTAEEIDLSKDIHDWNNRLNDDERFFISHVLAFFAASDGIVNENLLERFSNEVQVPEARCFYGFQIMMENIHSETYSLLIDTYIKEQKQRTYLFEAIDTIPCIRKKADWAIRWIQDKDSTFAQRLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLNYRPDPSAVEAIITEAVTIEQEFLTDALPCALLGMNAKLMCQYIEFVADRLLVALGNKKFYNTTNPFDFMDNISLAGKTNFFEKRVGDYQKAGVMASTKKEEDSSEEPENGGAFRFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2R9</accession>
    <name>D4D2R9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024412.1">
        <property type="nucleotide sequence ID" value="XM_003024366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2R9"/>
    <dbReference type="GeneID" id="9579634"/>
    <dbReference type="KEGG" id="tve:TRV_01375"/>
    <dbReference type="HOGENOM" id="CLU_024081_2_1_1"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="191"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="432" mass="48875" checksum="6EB91DC3C8DAEA4B" modified="2010-05-18" version="1">MESGTLESPKLDGFSLVLPLPYRVAVILVAGVWGWGLNVQYLTAVKIDVPALIRYPSRPNTAGTVTVHRSTYHLATLLSIPLAISLLAFWFITYGDPARVIAWEVLPQSYLFLFIVLLAFPLHRLSRGGRYRFLTTLKRVSLGGLAESQDGKFGDIILADVLTSYSKVIGDLFVSSCMFISSDASSTSIPDRACGGHIAVPLLIAVPSIIRLRQCLIEFSRVYRRGNRRVDGWGGQHLANAAKYATALPVIALTMLQRNYDASVIGVSEETLHKLWYVHFYSTLPLTQLLTSSRILSAVINSSYTFYWDIDKDWDLCLFSDIVGQFRPTSTLRDENPHPFGLRANRFFHANAIYYSAIVIDLVLRFTWLSRLTTRLNWVNDLESGVFALMFLEVIRRWLWIFLRVETEWVRNIRGPAPDDILLGEFTKMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D316</accession>
    <name>D4D316_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024406.1">
        <property type="nucleotide sequence ID" value="XM_003024360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D316"/>
    <dbReference type="GeneID" id="9579628"/>
    <dbReference type="KEGG" id="tve:TRV_01473"/>
    <dbReference type="HOGENOM" id="CLU_047431_0_0_1"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48655" checksum="C8575822717D6407" modified="2010-05-18" version="1">MSTTPSSLRLDPDLFDPSWVALPNDKGATGGLSFASTQIRNSWIVRLDFRQNSAPKGEKSHGTGFYVNIPGTKAHVILTAAHNLVDKQNKPSQDLQFYDPLQCAIIKPGDPDIFVSPSYLSRPRTETDFGAIRVPTSTSVSRGFGFALKLAEESLRDKSLQICGFPSDCTRPEPSTSSGDCKRWNRSRLEYQIATAKGLSGAPVFMPFKGHDTVVGIHETVLEQIFRWLGVSHEEKALRVFPSKDAPLEGLYLRFPPFEQHGWVRLGEQGLETTFDIFPAYAPTSNLTGKPTYVFRFRHPRGWPQSREKQRWVLWDYVRQVVTLTDKLEDCCFPYIVRIEPKKNSKKKPTNNSEMFRIVLERKDPENPADIGQLVEFRMANFLLKEEDIEMEEMDTPEVGFMKHYINKPAKVCFKAAVQSLWISTNEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D341</accession>
    <name>D4D341_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024361.1">
        <property type="nucleotide sequence ID" value="XM_003024315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D341"/>
    <dbReference type="GeneID" id="9579500"/>
    <dbReference type="KEGG" id="tve:TRV_01498"/>
    <dbReference type="HOGENOM" id="CLU_024875_1_0_1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="498" mass="55220" checksum="8CCC82721C8D5895" modified="2010-05-18" version="1">MHLVLPPPAAPAISPPSEASVAAARELYRTTQAMRERLLSEQYSQQRNDSASTNVATTQQDGVSEGVGDRGTLDVYPPPDGGLILQEDFPPPYMRPSISYQFSQQQDSSSNGAPGSRLHVHGTANGQPSGGPSDPNRMNSMPYQVMHIATEIISMEARLPRGPIPREDEISVVRDQLMRLFDAPNHNVPVLRGWLVRLSMLSSRSEQLRQYYARNPHLHSGQTGFASPSTAFSRRHPAYLLASPTRYEAVLIPAVHGRMASANLTGPMSSSSHPAFQPTIQPTLQQNALAMAYNNLPQATTANQRPLNIPGMLVRRRRLIVRGSTLVRAIRATWLFVRLYFFCYILSDSGTWLRLFLVVLSIAWACLSEVEIPHHIRRAIFIPLEDHIHDLLPADPGPAQPHRARHNAGPNYITDLLQRHRTLARGIVLFFSSFIPGVSERQIVDLQGINAFRENERRAEQENREQAAQQQNPDDSAPAEPNATGEQANGGEVEAIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C8</accession>
    <name>D4D3C8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport membrane glycoprotein Sec20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024237.1">
        <property type="nucleotide sequence ID" value="XM_003024191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C8"/>
    <dbReference type="GeneID" id="9579357"/>
    <dbReference type="KEGG" id="tve:TRV_01587"/>
    <dbReference type="HOGENOM" id="CLU_038503_1_0_1"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="44185" checksum="D49AF44EE016D4A2" modified="2010-05-18" version="1">MVASLHSRLASVEASIERVSALIRRLHSFGSADAYDDDERINLSTEIHQDLGEIEEEIEVLRVETHPLDRRRHQRRESVPFDADAVKNVALMAKIEEDLKMTRSKFRRAQIEAKRSSEKAKNRQRQLLFQPSAEGEDVPNRRTPRFTHGDLVASSSKDVTAALRQTHNLMQAELSRSQFAQEALEQSNKALSSLSESYTNLDTLLASSKSLVSSLLRSQKSDTWYLETAFYILIGTISWLIFRRLLYGPLWWIVWLPLKIVARITFAIFEVTSGVSVAGSKSVVPNKPLVTANMGPTATNSLWNPDSTKKADVTGIPDMAEEIKSWTAADQAEEETTMIPSGPKANERNNDLTSETIELAPFFHTIALLSSVPNNCEIGPQHGRGKKYIPAAPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3M7</accession>
    <name>D4D3M7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024188.1">
        <property type="nucleotide sequence ID" value="XM_003024142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3M7"/>
    <dbReference type="GeneID" id="9579226"/>
    <dbReference type="KEGG" id="tve:TRV_01687"/>
    <dbReference type="HOGENOM" id="CLU_012355_0_0_1"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="735" mass="82941" checksum="C2B1B577D69D6A77" modified="2010-05-18" version="1">MSSSGAPYCIICGVLIHNRTRRNEWPGQYRAGKNVCFHHYIDSNGTNPAHTIRLVRAASLNEEPFLTGVARFVHGERLLRAPSNPYERYENDRYTNETKSDEFPSQGRTSEDHPLPGFVFHDACWGILKALVHPQEISIPRLYDLCLSFPSQEFGLLTWGHGYESSVSDAEIVTHYRSTYQQSFFLRDPFDIPELQEALDEAEKERSNENTAERSIIAERADCDKFYSLPFEIREDIQCMLSLRDVFNLRIASRSFGSMPLSQHFWRSRFLPSFERGFIFEALRPQLDKATSGATIHYNWKALYEKTNPNLKHFEAIRNRRRIWECNKSLAALLISQPPLEDGGAYSMEEHNHVLWRTAAAKPLEPPRTQPSRGRFPGSAPLPPPSIVKEHAIRVPMQVSHVGVSLVCFGGNTYVSGIRISTPDEKEVRLGYIRPDNEVILNISQKGAESNSHPLTGFAICADPGGIRGIRTATADGALSNWAGDHHDVPSTLRLCLNERVTHIKAKFDAFRLISLSVPEEEQIHSQNPPCLSPRKATLWYPHIPCEHQSLHELDFVYQDEPQPSLLSYQQPHILLMFGGEKGSYLPYLTKISVSTLGGILTWIDFHYECDGAPISCLPVYQGREKHGNQSKIQFNIDGPGGERVTGFRVKDKQWRTPKNEPISFSIATLEATTNRGRSFTFDANVLPKIRLPLGHGQQKKKKLDIEPGSTITGIYITHEPPNGLTGLGIVSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3T6</accession>
    <name>D4D3T6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000092">
        <property type="protein sequence ID" value="EFE43486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024104.1">
        <property type="nucleotide sequence ID" value="XM_003024058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3T6"/>
    <dbReference type="GeneID" id="9577091"/>
    <dbReference type="KEGG" id="tve:TRV_01748"/>
    <dbReference type="HOGENOM" id="CLU_051050_2_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18882" checksum="3BE6E19E3163ED34" modified="2010-05-18" version="1">MLIEIKSKEATSKKEPAIKVTAMPGKHVPPGPLSTANDILKALHEGSIYNVANAVCDRIYISGDTLMCDELKEIPKIYADQKIDLMLIHLGGTTIPSPNIPLLMVTMDAKQGIELLKLIFVDYFISDYDVFLSPLSDFKKAVEEAGLSSKVVYLDRKDQYKFKTTWTDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U9</accession>
    <name>D4D3U9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024092.1">
        <property type="nucleotide sequence ID" value="XM_003024046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577080"/>
    <dbReference type="KEGG" id="tve:TRV_01761"/>
    <dbReference type="HOGENOM" id="CLU_002523_1_1_1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1360" mass="152421" checksum="E55C27B8E8212083" modified="2010-05-18" version="1">MVGFAAGQLIKLADGRHARIRFIGTTRFAPGEWIGLELEDATGKNDGSVQGERYFECEYGFGMFVRASAIVEIVEQARKEEPRVAPKSGLDGRGRPGSMIVPPGGAVGTRRQSLMSSTPGGKKSSSAASSPSPAPRALGRVLRSPTKSPVKQLAGPGTPAASRASSTASRTIPSHKPRPSLSNRSSAAPTPTSTTSNSRLSLRQSQPQSTMGPPAKTTRTGLAASRTTISPATSRRMSLKPATAKSPVMGKVEASSGEQSEDASRASSPPDGPELDVVKPSLARPTPSPMSQRSVSGSNMLVQKELDDLKTKLKIMEKKRAEDREKLKMVETYRTERDKFETIIQKLREKYQPQQQEITTLRKQLKEAEYRVEEVERLQAEHESILEMAALDREMAEEVAESIKAEYEALKIRTEELELEVEVLKEENDQLGQVMSPEEKSSQGWLQMERTNERLREALIRLRDMTQQQEADLKDQIKDLEEELKDYNNLKAQYESTKEKLLASEANMEDLKQQVEALGAEEMIEELTEKNMQYQEEVNELKAIIEDLESLKELNDELEINHIESEKQLQEEIDFREGIYHEQNRKISQQDAVIEDLEYTLSKFRELVSTLQNDLEDMRASQQITETEATDLTVRSRAMMDLNMKLQASAAKAQVKSMDLELGRMEAEESASHLSIVKLYLPDYYESERNPILALLRFKRVGFKASVMGNAVRERLADPSIRFPERDGFLAYEVLEKLTWISLVCDRFITFMDGCSSEQFSSFEGALYELEPVERILNFWIESLKKGELNEKTCADELQRSTALLSHLAETLIPQHVEGTGNEMYMLSVLTQTYLDSTASAFAQLKSKIQSKIPPSPEDEESQHLYKKIDTVVQQARGIKVASSKVTRSLEELRTRSLALAEECKEAFESTEQAAKELSEMAQLIGNSFLQLVDDDDRTEPFTYPEVLTSMSDAIASIPKGSLGDSGSNDALALIANKLRLLTGYVDEASNLSSDLSQTVEFDRRQSPWIARSKMLKASQETSPDAEEEIRRLRNELSEASNALGAKDRVFEEQSIKIELLEARMREASKKAAVVKDLEAEIGNLHSKENELVALVERQSQNMQAIERERDEYRSRFEKLKRASDSEGSSGVGGVVNAAASLSVMKENEALRAEVTGLQSSIRYIRDDNKRARLLDPYSVQRSNHMRSWLDVPLVRSKPSVNEQDPDHRHKQAAECRDILGHLLKLTKESKLVDLKASSTSDPANRLAWCPVKSTPKYHAMKQREHYEQWSQWKDEVVKERKMKKLNAGSGTTRRVLPTSNPSAPASFPVDHAAFPDISRKGLAPDRDEGVMGKTWKILGLQPDTGDIPRVSNEPQILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3V5</accession>
    <name>D4D3V5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024098.1">
        <property type="nucleotide sequence ID" value="XM_003024052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577086"/>
    <dbReference type="KEGG" id="tve:TRV_01768"/>
    <dbReference type="HOGENOM" id="CLU_000192_0_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1466"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1494"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="1720"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1778" mass="198020" checksum="4CBE85B12076E51F" modified="2010-05-18" version="1">MANRMSIYSALSSVSQDPRSTAQQTTQVSTTTLLNALHTSYASAQGYQLEAGTSLVVNTWLTTTTPGPNGEVGGTLDPSLARRAWEHARRRAEDGCIVLCTSHQSSPSLLFPMLGSLPLSTPEIAYTAISAIRPFVSQVTPYNPTALQYSAFAVSYTFTLTGRVTEIQLSVSNSGINTSHGLFNVPAEAGYRAFDVFYYLITSSSTPAEREFLGITDPSAFALLKKSGTFDPPSYLPTADDAAAAEDFRNCLKAIGIKGAAQRNLLSVLAALLKLGNAMGLLVDQEEIEDVCEDVGGLLNIDPLILLKNFNTDEREALMAGIYDALLDWIIAKANEAIHNEIVSVHENGSSDGGRQDESADTVGLTVVEIPDPALGKVVALRGAFDDTVGINAEIKEDGVEVISPGHSVLSEMNAAKAEVGVHLGMTDNAAARERDYFNDKVDGVLEKIGVEVEPGCFIRQLLYPVPGQGVRYGQTKRFDLVNTLGSSRVWYHLSVHPTDDLPAALASLPSATSAWSAGTVSRQLRAWRLPEMANRRNKRLDFTADFDVEEFVVRYAPLGCQEGKDGVENWVLERGWSNGDVVVGKERIWMRESAWWEAESMLDLIPQQQAASNPFNPGMTSNFDPGYTPSPQGMNPGMNQSGFFTADGMSIQGSHEQLVNRQGPGTIAGTVATSPGVAQSVAPTMNRASRNIGDYGLGSKGDDIKYDDTYYDEALGRYVGQVDPEFAEPKSIEHESITFGRRVWIGFVWALTFWIPSPLLRYVGRMKRPDVRMAWREKVVLVALIVLLNCIIVFYIVEFGNLICPGKDKVWDSREVSYHQGEDDFFVSIRGHVYDISKFAKTPHTQGRKYPTDRESMQPFAGQNMDAYFPVPLPLACPGFGIKPEIQLIPNNTDTIQNSIAIHKSGKTVVTDPTVKTHEDDWYPRVFQPAIKEYYKGDLVWSRKNVTEQAKQFDRKWVIINEKVYDLTDYFNSIDKMDGYPGYDFLPSVVTDLFKKEAGTDITSLWGDTTDFKNSMNCLANQFYVGKTDFRDTPRCQANNYILLAFTVILCAVILIKFLAALQLGTKRRPAMQDKFVICQVPAYTEGEDQLRKAIDSLTALQYDNKRKLIFVVCDGMIVGGGNDRPTPKIVLDILGVDPKIDPPALPFKSVGEGSDQLNYGKVYSGLYEYEGNVVPYIVVVKVGKESEQNKSKPGNRGKRDSQVMLLRFLNRVHHRAHMSPLELEMFHQINNVIGVDPELYEYLLMVDADTSVREDSLNRLVASCANDAKIAGICGETSLQNEERSWWTMIQVYEYYISHHLAKSFESLFGSVTCLPGCFSMYRLRTQDKGRPLIIFEKVISEYADVRVDTLHQKNLLSLGEDRFLTTLMTKHFPHMSYKFIPDAYASTAAPETWQVLMSQRRRWINSTIHNLAELMLLKDLCGFCCFSMRFVVFIDLFGTLILPATTVYLGYLIYLVAAHKGQFPLFSIILIAAVYGLQAIIFIIKRQWQHIGWMIIYLMAFPFYSFILPLYSFWHQDNFTWGNTRIVIGEKGDRKVIAVEDEPFDPKSIPLQRWDTYALIHNLPGRRGNPNAQEKAGFPGYNDEAAVEMDDMQSMYSSVKPASTILTGFPTQGVQQTPYVLPHSPNPYSNLPGNRNSHMSHFTHYTDQPQLGNRASQHLSVSNLSHYQDNPTNASRLSGFGVPGSENFAPSQRHSMRSSMPRPASTLVDFRNPPGQGPDEATITAAIQACLGEVDLDTVTKKQVRALVEQRLQTTLSGEKKAFLDRQIDNELANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D487</accession>
    <name>D4D487_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023960.1">
        <property type="nucleotide sequence ID" value="XM_003023914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582653"/>
    <dbReference type="KEGG" id="tve:TRV_01902"/>
    <dbReference type="HOGENOM" id="CLU_002333_0_3_1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="4">
        <location>
            <begin position="793"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1417" mass="156374" checksum="4D1794606F392464" modified="2010-05-18" version="1">MDSQGSQGNSGPPRANGRPIHIGHRRSPSEMTPLIMEQLALQQQIEVLQQHQQQIAAQQQQNQQFLNIGMIPQQQMQQMQPLAYPQMQGQGVMPVGFQFPQMQGQQQLGVPGQSSHRRNQSALPNVGMGPPPAPSSGASGSQYGENAQSRGGQGRENNNNTNNSNNNNNSQSRRGAVPAGGSHHRRHSLALPEARRAAELAQQRQTAGAFKFPIPGGAGASPSSASQGQGQGQGDANDDKPAEVAGPAVPASSPLAAGLGVQRSGNIRNAHLRSQSMAVGGARQYSGRNNPSFQFPQGGESSGSPGPDAGRRTSHASHGRSGSRNFDSNWRQQGGAPNTASSGSGNQDPRASLGGLSPQPQQSGNGFQPGHRSRGSVSSMSAFQFPNTQQLFQLPQGQVVLPQMYQGQQQQLLHNNALQLAQLQALQSGQLGSLPQNLQLVGQQQASQPQQQSQTQAQQNRKTLFTPYLAQTMLPDLFEEGKLVTGILRVNKKNRSDAYVTCSDLDADIFICGSKDRNRALEGDLVAVELLDVDEVWSQKREKEEKKKRKDIDTRSGSTAGLDRGGRSDSNATADIQQIGPDGSIRRRGSLRQRPTQKKNDDVEVEGQSLLLVEEDEISDEHKPLYAGHIIAVVDRAAHQIFAGSLGLLRPSSQATKEKQEAERQARDGYSGRPQHERHQERPKIVWFKPTDKRVPLIAIPTEQAPRDFVDRHADYANTIFVATVKRWPITSLHPFGTLCEQLGPMGNLKVEIDALLRDNNFAADDFPASVLDKVGFEDWSIGQEEPQSLASRTDFREYNVFTVDPNGGKAMDNAFHIRRLDDKTVEIGIHVADVSRFVDPSGAVEREAKKRVSSAFLMNRIVDMLPPHLAQKVMALLPGNDRLAVSVLLQVVVESGKIVDQPWIGKSIINSKGKLSYAELDKIIKGTGQVEVNGVSVKDIKMLVDVSNKLRDARLGHRAEKLRPLRLLYQLDDENVPVQQNIFNSSPGREAIDELTYMANHYVARKIFEAFPEHALLRRQASPNFRRLGTFVERMSKLGYNIDPTSSGTLQNSLFKVENDDVRKSMETLLLKTLSRGKYYTPPTVREEHRSHYMLNLSLYTHFTNPSRRYADIVVHRQLEAALAGTTEWQDELDYKALNYLNSRKDSAQNAQEQSVHFEACHAMERKRKEIDGDLIAEGIVLCVYESAFDVLIPEYGCEKRVHCDQLPLKKAEFRKDDRVLELYWEKGVPSSTYIPEDERPKSTLSGRAASQAAAAREAEEARKREQEREEAQRISTETNTVSPNDVDALFDDDEDALTDSFAGVSLNSPDRSTQSMPPSPRNGPAHPPHRTQSDPRIATTAGETTNDEDAEGGENAKNTQNGEDGEDGEIVELSPKEKYGDLFELREEDGEYIQDVRELTRVPIILKIDLSKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4C3</accession>
    <name>D4D4C3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023888.1">
        <property type="nucleotide sequence ID" value="XM_003023842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4C3"/>
    <dbReference type="GeneID" id="9582488"/>
    <dbReference type="KEGG" id="tve:TRV_01938"/>
    <dbReference type="HOGENOM" id="CLU_030880_3_0_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51666" checksum="AA59C9E574B56976" modified="2010-05-18" version="1">MSQPQQDTEWSRRDSAVKRGQLSIPSDQGNAIEVRALRSSISDAGSLMHNLSLSPSFQDRRGSRNSFGMALPIPKSPRASRLSGSRDPASLKRDVLASQIQDMAKEKVEAAKNMAFAFDIDGVLVHGKKLIPEAARVMEVLNGDNELGIKLPYILLTNGGGKTESARVDELSGILKSPISTEQFIQSHTPMQALSEYYDTVLVCGGEGFKVRQVAEDYGFKTVVHTKDIQAWDPTISPWSQLSEEEVKQAKIRDFDNLNFDAIMVFADSRDYQTDMQIILDLLLSENGRLKTKAKNPLANQIPIYFSQGDIVFPTEHALPRLTQGAFRIAIESQYKTLTGGDLERVVYGKPELATYKYADTVMQQWMKEIHNEHTLPKNIYMVGDNPQSDICGGNMYGWNTCLVRTGVFKGGENDTNNPANFGVFANVLEAVQAAVKKELGQEFKLKWQDEEVNPVLQAGGVSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4C8</accession>
    <name>D4D4C8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023893.1">
        <property type="nucleotide sequence ID" value="XM_003023847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4C8"/>
    <dbReference type="GeneID" id="9582493"/>
    <dbReference type="KEGG" id="tve:TRV_01943"/>
    <dbReference type="HOGENOM" id="CLU_994632_0_0_1"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055977" evidence="2">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="24502" checksum="1E366FE29C63E061" modified="2010-05-18" version="1">MRFSVASLLFLGATLVAAGSVPDDSSASSRSAHSLSRTGNNLKARSNIFARASGDEHCSGRGVTCQSCFGSGYKECPNDSTKCYNPDDPRYSSCDPSGGSGGSGGSGGSSGGSSGGSGGSGGSGGSSGPTDESCARQYGTGNKVCGTDSCYNPTVGETCCQNTGKSAPSLAPFAVLLNPDCRGISSNDSTTTSSSTSTSTYTSGSSYPTSTNVSGSSPSSSPDTPQSNGAGCLSVNVFPILAGGLGVIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4D5</accession>
    <name>D4D4D5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023900.1">
        <property type="nucleotide sequence ID" value="XM_003023854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4D5"/>
    <dbReference type="GeneID" id="9582500"/>
    <dbReference type="KEGG" id="tve:TRV_01950"/>
    <dbReference type="HOGENOM" id="CLU_2833010_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="66" mass="7477" checksum="B49E48F9D21ADC0A" modified="2010-05-18" version="1">MLLQGVSPLLMEKKKKQQQQRKPGKRRRHGSGLPLPSHHAASCILHRINIDQISCNPGLIDKANFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4F5</accession>
    <name>D4D4F5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023920.1">
        <property type="nucleotide sequence ID" value="XM_003023874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4F5"/>
    <dbReference type="GeneID" id="9582532"/>
    <dbReference type="KEGG" id="tve:TRV_01971"/>
    <dbReference type="HOGENOM" id="CLU_045001_0_0_1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="37560" checksum="1076BC1815C2227B" modified="2010-05-18" version="1">MEYAQYQQPQHQASPIVPPQPHPHYQGQPQQPPPPPPPQQQQQQQQQQPQQHPPPQQQPQSQGQPPQPGQMSFPQSYAPYGISPTQAAAMATAAATGQFFPLHQDSTRLPIKNERPRQSPQQAHAQPSAAAAAAAAAAQRRMSQQLSGSPHSMPRQPQQPPPPQPQQQQQPPQSQQPQPQSQTQAPPPPPQQQPQPSPELAPPGPPAEESPLYVNAKQFHRILKRRVARQKLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMEKAQGGSTGTNNNSASTNENKEVTGQKRKSIAESSSPGSKKPKTSPLRTGANANVAAAPTETSDAEDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4G9</accession>
    <name>D4D4G9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023864.1">
        <property type="nucleotide sequence ID" value="XM_003023818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4G9"/>
    <dbReference type="GeneID" id="9582475"/>
    <dbReference type="KEGG" id="tve:TRV_01985"/>
    <dbReference type="HOGENOM" id="CLU_042860_1_2_1"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="134" mass="14816" checksum="FEDA6BFBBABEBD24" modified="2010-05-18" version="1">MQFKPKKPVTLPTAPPPTVFRTFSPTDLLPFNGKNGAPVYLAVRGRVFDVTPGKNFYGPGGPYENFAGRDATRGLACQSFDEEMLTKDLKGPLDDLKGLGQEELENLRGWEERFLEKYLVVGKLVAEGDPALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I6</accession>
    <name>D4D4I6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023806.1">
        <property type="nucleotide sequence ID" value="XM_003023760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I6"/>
    <dbReference type="GeneID" id="9582379"/>
    <dbReference type="KEGG" id="tve:TRV_02003"/>
    <dbReference type="HOGENOM" id="CLU_1338385_0_0_1"/>
    <dbReference type="OrthoDB" id="4173769at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055567" evidence="2">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="179" mass="20417" checksum="0DC1D5AF18765118" modified="2010-05-18" version="1">MFLIKLLLRIASLLLDIVSILLIEEEAHRRQHRARAEPPDAPSIDTTMENLQENVGVIEAETPENEMWIMEYPTYQSLYSSSNTLSDDSSLEESEEEGIPTLEALWANWNPEPDQIDYPDRPTTPGILETTLANDADTIWQVSETDEESNQPEPHRSDTPDSIEYIFNPTGRLEMSDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I7</accession>
    <name>D4D4I7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023807.1">
        <property type="nucleotide sequence ID" value="XM_003023761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I7"/>
    <dbReference type="GeneID" id="9582380"/>
    <dbReference type="KEGG" id="tve:TRV_02004"/>
    <dbReference type="HOGENOM" id="CLU_025946_1_0_1"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="463" mass="50668" checksum="C5471A9036F86CF9" modified="2010-05-18" version="1">MTPATHLQPITSLVVDPTNNFILSGSEDSSVHVWSLPDLITFSKQSSADKSLSAIYSCSPIRTISNHTTAITSIAVGHSINRSNIAISTSQDGTALVWEYRTGKILHTYLLPSRPLCITVDPADRAFYVGYEDGSVQLVDFFKTPSVQHILHDTDHQTTPTQLSASDKWLPPSSELGATLCLSLSYDGTSILTGHRSGAVASWDVGRARYAASIASLNSPVTNLHMLMPEGLAQKVSRVAIHQIVKPRLDHTMGGGQASDAVPATYHVNVHLNGPQSTDPSMPSSVLDEFSAALSHPIFPGSLISESLIDLNSPSENTPTNNIAAPVTPTEASIWPVKKKDRKALETEITSLKRQISVHKATHQADLDEIIALRKDVRYLSDMSIELLEEQRIALDKEAKERSLKKVSDLAGRKLWFSSEKDGTNGDHYRIKRVYGNSAYDDEDDDEDLDDEDLDDEDEEMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4S6</accession>
    <name>D4D4S6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein YMR-31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000111">
        <property type="protein sequence ID" value="EFE43150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023768.1">
        <property type="nucleotide sequence ID" value="XM_003023722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4S6"/>
    <dbReference type="GeneID" id="9582340"/>
    <dbReference type="KEGG" id="tve:TRV_02093"/>
    <dbReference type="HOGENOM" id="CLU_129439_1_0_1"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13202" checksum="5F14C063BB2A4DA6" modified="2010-05-18" version="1">MQATTVLRQAAAARQPLIKFMGKRSIPASIDHSPQPHPASPTHQLPDSFVTYRAKAQQHGPLNTTYRPFSSIGASSGAALGPVTPKKGEYFDRNDLPARFRRAPWSQAEIDAIETGGASMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4U6</accession>
    <name>D4D4U6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023726.1">
        <property type="nucleotide sequence ID" value="XM_003023680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4U6"/>
    <dbReference type="GeneID" id="9582294"/>
    <dbReference type="KEGG" id="tve:TRV_02113"/>
    <dbReference type="HOGENOM" id="CLU_1176155_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="236" mass="27099" checksum="9F0120A084E3FF49" modified="2010-05-18" version="1">MTTISYRIITRLDDRRRSRWSTTRVEVSEDDVQVLQLTAASVTASATAIWRPYQQPAASNCSFATAKKKKRHRRCRRRSKKKKNKRQKKKGKEKKKRGAESHPVCWYNPSARLACHGTDPGWLKEEEERSPPNLLWLELFVRFSWKADGLVQWQLVSSALALGFSIGPVCLAKGEKGKTGRAQKAKHSKVQSGGGPVQPENDREKKGRKKRERRKGKEGKKGKRTKNKNNDYDYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D533</accession>
    <name>D4D533_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023694.1">
        <property type="nucleotide sequence ID" value="XM_003023648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D533"/>
    <dbReference type="GeneID" id="9582242"/>
    <dbReference type="KEGG" id="tve:TRV_02203"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="97"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="349"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="465"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="565" mass="65093" checksum="11A4FCFC27F1C074" modified="2010-05-18" version="1">MPAKKRKGSEAFAPEESRQHTASSQLASRSLPDLRQPHPNAQQTEDFGIVLRDFYPPEISNARCHAYNEGVLERPIEALQRAYKETTEQCQDIQPGKAVVHWFKQDLRLQDNRSLHRAYSFARDHNIPLICLYIFSPEDLTAHLCSPPRVDFILRTLATLKSELSKKDIPLYMESMERRKRIPIRIVELCKTWGANHLFANIEYEVDELRREAKLTRLCTTQGIRFDTEDDTCVVAPGELTTQQGKQYAVYTPWYRSWVAYLKQHPENLELVDAPAVNAGDARKHFEDLFDSAVPIAPNQMKLSEAEQERFKKMYPEGEQEATRRLREFLSEKGKQYRSKRDFMSSQITSVLSPYFSCGALSARTAPFIEAMKLCGLVITDVSSSMNKCFKPEFTDLEWGYDSTQFDAWCEGKTGFPIVDAAMRQLKHCAWMHNRTRMIVSSFLSKDLLIDWRRGEQFFMLHLIDGDFASNHGGWGFGSSTGVDPQPYFRIFNPLRQSERFDPDGDYIRHWVPELRDVEGSAIHDPYGRGAEEIAEKNGYPRPIVNHTESRERALEKYKKAAHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5E3</accession>
    <name>D4D5E3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023566.1">
        <property type="nucleotide sequence ID" value="XM_003023520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5E3"/>
    <dbReference type="GeneID" id="9577038"/>
    <dbReference type="KEGG" id="tve:TRV_02313"/>
    <dbReference type="HOGENOM" id="CLU_061199_0_2_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30293" checksum="33C4D0A74C83F1FF" modified="2010-05-18" version="1">MYPRGPYESDMCGDASYRNILYVGSAAHRQITLIHPGYSVVLIYQPALRTALKMLGFEDTYHMYSCAVENQRDCEMWIDATRAKFEGVGSFEKRDWDALLGHCQATTDAPGCVFIPELVAAYPDAKVVLNKRDVDKWYTSVLDTIHKAHIANRELGIQGKRVEMLNLLWGHLFHGDFRKNGKEVWEQHYQMVRDLVPADNLLEFEAKDGWEPLCKFLGVPVPDVPYPRVNDTSNFWERYEKGTGASLEKVNEIVAKVEKVECSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M3</accession>
    <name>D4D5M3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023459.1">
        <property type="nucleotide sequence ID" value="XM_003023413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M3"/>
    <dbReference type="GeneID" id="9583488"/>
    <dbReference type="KEGG" id="tve:TRV_02396"/>
    <dbReference type="HOGENOM" id="CLU_1564009_0_0_1"/>
    <dbReference type="OrthoDB" id="10466526at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="196" mass="23609" checksum="EFB436CA48B8841A" modified="2010-05-18" version="1" fragment="single">SNIQNMSSTAPPPANSATKSRGRGERPEGEECHDSWIVEKRRLISGSDPEEDKAEIKRHIEEVEDLIQEGYAKWGRRQIKREKKKAMKRELKEVKEKIKERKMESNRRLKMQREGEKELKRELKMKLKEERKRKKEKKEELKKQMKMEKKKEKMKREWERETRRESWRMAEASEREGSEQEASIASDRAVFHLPLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5P5</accession>
    <name>DPP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl-peptidase 5</fullName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dipeptidyl-peptidase V</fullName>
            <shortName>DPP V</shortName>
            <shortName>DppV</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPP5</name>
        <name type="ORF">TRV_02418</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini. Contributes to pathogenicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023434.1">
        <property type="nucleotide sequence ID" value="XM_003023388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5P5"/>
    <dbReference type="SMR" id="D4D5P5"/>
    <dbReference type="ESTHER" id="artbe-DPP5">
        <property type="family name" value="Prolyl_oligopeptidase_S9"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="D4D5P5">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9583454"/>
    <dbReference type="KEGG" id="tve:TRV_02418"/>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397822" description="Probable dipeptidyl-peptidase 5">
        <location>
            <begin position="20"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="726" mass="80011" checksum="270BB1E6DBA90712" modified="2010-05-18" version="1" precursor="true">MAAAKWLIASLAFASSGLAFTPEDFISAPRRGEAIPDPKGELAVFHVSKYNFDKKDRPSGWNLLNLKNGDISVLTTDSDVSEITWLGDGTKVVYVNGTDSVKGGVGIWISDAKNFGNAYKAGSVNGAFSGLKLAKSGDKINFVGYGQSTTKGDLYNEAAAKEAVSSARIYDSLFVRHWDTYVGTQFNAVFSGALTKNGDKYSFDGKLKNLVQPVKYAESPYPPFGGSGDYDLSSDGKTVAFMSKAPELPKANLTTSYIFLVPHDGSRVAEPINKRNGPRTPQGIEGASSSPVFSPDGKRIAYLQMATKNYESDRRVIHIAEVGSNKPVQRIASNWDRSPEAVKWSSDGRTLYVTAEDHATGKLFTLPADARDNHKPEVVKHDGSVSSFYFVGSSKSVLISGNSLWSNALFQVATPGRPNRKLFYANEHDPELKGLGPNDIEPLWVDGARTKIHSWIVKPTGFDKNKVYPLAFLIHGGPQGSWGDSWSTRWNPRVWADQGYVVVAPNPTGSTGFGQKLTDDITNDWGGAPYKDLVKIWEHVHNNIKYIDTDNGIAAGASFGGFMVNWIQGQDLGRKFKALVSHDGTFVGSSKIGTDELFFIEHDFNGTFFEARQNYDRWDCSKPELVAKWSTPQLVVHNDFDFRLSVAEGVGLFNVLQEKGVPSRFLNFPDETHWVTKPENSLVWHQQVLGWVNKWSGINKSNPKSIKLSDCPIEVVDHEAHSYFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5P7</accession>
    <name>D4D5P7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023436.1">
        <property type="nucleotide sequence ID" value="XM_003023390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5P7"/>
    <dbReference type="GeneID" id="9583456"/>
    <dbReference type="KEGG" id="tve:TRV_02420"/>
    <dbReference type="HOGENOM" id="CLU_045495_2_1_1"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="277" mass="33006" checksum="C82CF2BE759155BF" modified="2010-05-18" version="1">MNAIRQIEALNKKELENAVPPEASWHADYRDTAYIYIGGLPFDISEGDILTIFSQYGNPVHLNLVRDKETGKSRGFAFLKYEDQRSTDLAVDNLGGATVLGRVLRVDHVRYKRRDDEGTEDNLVNVDENGEVMESDRDAEKEKETEKSSRRRSRRHESEERRPSRPLLKEEVELQQLMDEHDDEDPMKEYLIKEKKEEVENALALVKAKSRSSRQDRDRDRSRDGHRTSRRHRHHRRRRSEERSRSRERRSPHRSRRDGSRERSSERRHRRERRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D663</accession>
    <name>D4D663_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023252.1">
        <property type="nucleotide sequence ID" value="XM_003023206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D663"/>
    <dbReference type="GeneID" id="9583285"/>
    <dbReference type="KEGG" id="tve:TRV_02586"/>
    <dbReference type="HOGENOM" id="CLU_686905_0_0_1"/>
    <dbReference type="OrthoDB" id="4179888at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="48722" checksum="08E9F442147F86D3" modified="2010-05-18" version="1">MFKDAKQKTQKKRGEGKHGKRATVHLHDMKTARCVCLMYCIVQVTAWSIPLRYLGVHTTLREPIAGRSASEETITQGAPPFQPPGITDNVRSAETTSYKDTMNGVTLERLLADLETCVEDLVPYSPEVPPNDIVQISGSKMRSCRQAIFTLIRWYRQSNPSTRKSSTETQNERRDDQKSRFNLVKPGDNTDPRQTGNLQTTATGKVRPTQTSTRPLTCRELACPSGDLAATCVTKPGIKLKPTLAQMCRMCFPRRDERLIDEHCADESKKEWNIFYILFAVLISISTAGFTLAIVRRLREKAQTSQNTASEVLPTKRFVDSGSTFTNTSPAEPMSRRVVSWLRGVVTYVRDSRARVDVEEHPELGVAAANSLIPTFVNQVNPNRPHPFQVSGAETCERQTGLKLRKSCDSSLDVPGKEGSPRARSSSVQATPDAVNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D679</accession>
    <name>D4D679_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023268.1">
        <property type="nucleotide sequence ID" value="XM_003023222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D679"/>
    <dbReference type="GeneID" id="9583276"/>
    <dbReference type="KEGG" id="tve:TRV_02602"/>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="107"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="544" mass="59979" checksum="F6165356D3489D2D" modified="2010-05-18" version="1">MAATASQKYLSSRGGSYGFSFEEVVLKGLASDGGLFIPEQIPSLPTDWETKWRNYSFQELAFEILSLYISPSEVPSDDLKDIISRSYGTFSGYLADANGLNRSPDITPLVTLDEQKRLYLLELFCGPTFAFKDVALQFLGNLFEYFLVRRNEGKTGKDRHHLVVIGATSGDTGSAAIYGLRGKKDASVFILHPKGKVSPIQEAQMTTVLDENVHNISIEGSFDDCQDMVKALFADPEINKTHKLAAVNSINWARILAQITYYFHSYFSLIRSPTYVNGKPIRFVVPSGNFGDILAGWFGKQMGLPVDKLVIATNENDILDRFLKTGQYTKQAQPEAQASASAVKETWSPAMDILVSSNFERLLWFLAYKVYGQGDIDEQRKIAGNTVLSWLQDLSGKGGFGVDEKILQAAQQEFESERVSNEQTIDTIRSIYSTCFPQTPVSAGTRGETGGYILDPHSAIGVAASLRSISRCAETFHISLSTAHPAKFAEAVDAALRNEKGYSFDNVLPPEFVGLEKKERRVISMPAGATWKSVGEVINQNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6K8</accession>
    <name>D4D6K8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023155.1">
        <property type="nucleotide sequence ID" value="XM_003023109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6K8"/>
    <dbReference type="GeneID" id="9583163"/>
    <dbReference type="KEGG" id="tve:TRV_02734"/>
    <dbReference type="HOGENOM" id="CLU_1696787_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="155" mass="17770" checksum="D89E178083A7A9DD" modified="2010-05-18" version="1">MAIQVGQEKIFPPPSNSLQGKKETEKGTKMPLFVARLAPVSLTVIWDEVEKSTGWKIEVSETVRRTLYVKDISPKVNTIVTEEYVLWRVQAYIKYTETLETFYLVASHGSHLEIGYFQRKKPDIIPRLSEVFNGADRIQIMYLPAVAKLLHEMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6L4</accession>
    <name>D4D6L4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023120.1">
        <property type="nucleotide sequence ID" value="XM_003023074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6L4"/>
    <dbReference type="GeneID" id="9583140"/>
    <dbReference type="KEGG" id="tve:TRV_02741"/>
    <dbReference type="HOGENOM" id="CLU_1603948_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="166" mass="18810" checksum="81B0D622B973763F" modified="2010-05-18" version="1">MGDTNLKPELVREVQMGPFKHKVDDGLELRKSAYETLYTCLDVAFSAVNLPEVYDRIIAGIEDEQDIRTLCTLMISKLMTLAPEETLARLDAFSNSFRVVLSVKPKESAVKQELEKAQEASIGVLKVSRELQMAFPAAEASNDHHSWKSYVEWISKDFMQLLRSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6L5</accession>
    <name>D4D6L5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF614 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023121.1">
        <property type="nucleotide sequence ID" value="XM_003023075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6L5"/>
    <dbReference type="GeneID" id="9583141"/>
    <dbReference type="KEGG" id="tve:TRV_02742"/>
    <dbReference type="HOGENOM" id="CLU_824367_0_0_1"/>
    <dbReference type="OrthoDB" id="4172696at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="37704" checksum="FEB963F895DAE151" modified="2010-05-18" version="1">MSNHPPHYGNAPHYPPHLYPQQHEQQHLQQPEQRPYSYLHTPVTLQGPTFSSPDNPRHTAPSEQTNQQSHSQPNQPGNHRPFSYVSPDADKIVDESLSTVSNNRNDADYVNNLYTHVSPPPLSEHPAQFAPFADSTTPPPNPSQIHQAQEQEYLQQQQPRQQGEQYQQHFLQQHQQLQQQQHGVIPHSPMAIPKSPGPLPVKQNPEAETRERQAEEATIAPDSNPLAPQSPAPTYASHSGPQRMNGRSISAVPDIQCHTPGQAFHPQQSVKGGSWSTGLCECSDIGVCCLENQNGKTRLICLDMSPAMHHALSWLYYADVNVGYSSPRTPIRCRYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Y9</accession>
    <name>D4D6Y9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023045.1">
        <property type="nucleotide sequence ID" value="XM_003022999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Y9"/>
    <dbReference type="GeneID" id="9583065"/>
    <dbReference type="KEGG" id="tve:TRV_02867"/>
    <dbReference type="HOGENOM" id="CLU_029275_1_0_1"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51868" checksum="DB10105AF1B4E851" modified="2010-05-18" version="1">MAPTAIAKKGKGKKHADPGETSKLLAAKISQLEQDAAGEKDQEAEIEREVKKATRDLNQLLSTIESPMTRLETVHKKYTELLAEMKKLDRDHNKSKKRADQLQKDQDKGKSELNKTVTMKDKLEKLCRELTKENKKVKDENKRLDDTERRARGIVNERLDSLLFDIQDVMAAKGSSRVENVDIDLDEALRAKIKTIGEQFESRELHYKAILRSKDAEIQSLTAKYEEQRRSAENEAARCRALSTQVSTFSQTEAELRSQLNIYVEKFKQLPQMLKPVFTQVEDTLNNSNELFLTFRKEMEDMSKKTKRLEKENLTLTRKHDQTNRNILEMAEERTRNNEELEKWRKKSNSLEALCRRMQQQGRGHAVEGELDVDDEGTESEYEEYDDEDEEDLSEDGEYHSHGEGEQPHHHQHPAASGAQPTKPVFGPPPPPTMIEARSNGNLPVMNGYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D724</accession>
    <name>D4D724_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exosome complex subunit Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000149">
        <property type="protein sequence ID" value="EFE42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022966.1">
        <property type="nucleotide sequence ID" value="XM_003022920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D724"/>
    <dbReference type="GeneID" id="9582986"/>
    <dbReference type="KEGG" id="tve:TRV_02903"/>
    <dbReference type="HOGENOM" id="CLU_067135_2_0_1"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000164">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26886" checksum="205F79505CE7BC4E" modified="2010-05-18" version="1">MAASIPSIAVPGLRLGDSSTFTSGPGTYVRDSSICASIAGPVILKTDDKGTDPKRKPRKILTVSRSPQTDTPNPTQKQQQAKSPLKFNTLPAVDSIVLARVTRVQKRQATVSILMVVDDQNNDLIDTNMRTILSSAPIITTAGTDSTSTSNTADDLWFQAIIRKEDVRAVEKDRVVMEDMFRVGDIVRAYVISVGDQSSYYCSTARNELGVVMARSEGGNMMFPVSWKEMRDPVTGVGEARKVAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D733</accession>
    <name>D4D733_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022925.1">
        <property type="nucleotide sequence ID" value="XM_003022879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D733"/>
    <dbReference type="GeneID" id="9576983"/>
    <dbReference type="KEGG" id="tve:TRV_02912"/>
    <dbReference type="HOGENOM" id="CLU_721965_0_0_1"/>
    <dbReference type="OrthoDB" id="4173995at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="40687" checksum="A7049E5BD33AD54E" modified="2010-05-18" version="1">MAANDSTNNVAGTNAATGPAAPAVPAGSSTRFYSKHAQNKGQYGRRWDSSESKLETSGPPGALNSFPGPRPAAPAAPPAASRPNPAAPPFTPAPRKWGPSPAAGAPGSSSAGVDTGKDYKRKNRKFKPKKEKKDGTPTNTPVSDAPGGLKDTTNRRPQRRNMPGTRNPGMRRRNEEGGRSAAPGANQDEPTVVEAPAHDKTPAVPAQEDNAVKEPVGAEEPKAMTPPKEEDAKPAEVNQASDAPVSKDVEVSPPKDAEDTPKPASEPAEEKAEEVSPLTKWNPIFPPGGPRPTPAPNDGASGEQPRRTNYVDANGNYHAPNGTIMSAELLKLFATGKIRNSLGDKVYFMPSFIENHPPEGQQPYPLAGTPSRIFYDPREFKKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7A4</accession>
    <name>D4D7A4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD finger and SET domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022903.1">
        <property type="nucleotide sequence ID" value="XM_003022857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7A4"/>
    <dbReference type="GeneID" id="9576941"/>
    <dbReference type="KEGG" id="tve:TRV_02985"/>
    <dbReference type="HOGENOM" id="CLU_009510_0_0_1"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="292"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="999" mass="109084" checksum="68E4D1FC31CF2CD9" modified="2010-05-18" version="1">MTDTSSTAHAHSTANPFPFPATTSPLPSPVANGTGSTHEAEEDEPYTIKCICSFEDDDGSTVLCERCDTWQHIACYYIDKKNVPDIHNCVDCEPRHLDGKRATERQRKLREQNDSNSNATDEQRKSRRSGSKSQKKKPKDIGSPSGVGGDQRNGWSSHERAGSTASKENGHHHHQGQQLQQTKKQRGAHRSSNSISSVGGGDSRKRGNNINGKSPGSSFPQIPLYSPEFLHLYDNDNASLDMQGNLFRTIGLTNDLASWVKDPLALAQVANGRSAKEVFNHTDQPLDPSTWPPLTKQTIVDNHVEIDGRHPTWQCLKVQSNVRKDEIVGEVRGKVGHFRDYCHDPDSRWQELRHPEPFVFFHPQLPIYIDSREEGTVLRYIRRSCRPNVTMRTYITNQVEYHFCFVANQDIPMDTEISTTWYLDPKMFPSNGLVKEEGLPDGSPDAAAISISNVLAHFGGCACDDSVKPCLLANIDCRMKPKSLLESNTKQANGRRKKAKTKTAASPDSSGYVAAHSRSGSEIVRKEDDDDHADARSTSGSLKDHHFNRDLTPGALGRDNGELSAREKRKIAAAEKKFEQLEHDQQHPKKKKRVHPPRGQSPNLSKSAKPPHLDIPNSRRSSHSPAKMSPESASQRRDGHFTPPKTSAASTPRVVSPLSRPVYIDRSIQTDPDENDPQYVPPKPFPAPRFMTLSQRLLRRCLEDRIKMEEDGRLDSIPSLDSSETASAGTMLPPSTPVNSRLAPSPKHASDIEMKDADSSMTPPNATVSSASPTTTSSVSLSSPPPCPLFHLPSTVAHNLPTPRKIPGKPDMRIPLPPQLPPPTDSVGSPDSASKPAPPIAVTKPSQSSKLETTSPGQPAAATPTLTPTSSLTAPSPVKKKLSLNDYMSRRGTLTTPTTEKAPNPFLPNSTSPAASTGSADPSPTTQLPFTKFAETQTQTNGVGQNPPASTDIIMKDSPQSPSTLFPPSHTDSPSTSNGAKSNAIQDLSSRDPRLLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7F0</accession>
    <name>D4D7F0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03032</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022808.1">
        <property type="nucleotide sequence ID" value="XM_003022762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7F0"/>
    <dbReference type="GeneID" id="9581532"/>
    <dbReference type="KEGG" id="tve:TRV_03032"/>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="13">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="27741" checksum="EB7FF84A4145C5BE" modified="2010-05-18" version="1">MADQLPTLNFRFEELRSRMSQFSQKFDSFIERGRKQVLEERNQFYIDLAELQEDQRMKEKDIEILNLKLQTHRQTLQKESAEAAEMHAAISQISQQRDSRSAIRDRLQQQINETQRSINQRLEAQRAHAKQLELQSRQNVPELDFWQDLLCLRIEGAGREDRLKIIYTHLLEKDWEREAWFELGTAGHEYEVLHCRPKLDKSAITEVVDIVNDDRDFGAFLKRMRRLFVAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8E0</accession>
    <name>D4D8E0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2 transcription factor (Swi5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000175">
        <property type="protein sequence ID" value="EFE41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022501.1">
        <property type="nucleotide sequence ID" value="XM_003022455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8E0"/>
    <dbReference type="GeneID" id="9581075"/>
    <dbReference type="KEGG" id="tve:TRV_03376"/>
    <dbReference type="HOGENOM" id="CLU_013390_2_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001649">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="664" mass="73087" checksum="D36F6D26958F022A" modified="2010-05-18" version="1">MLQNFSFPPEPEGSKDVASLASRRHFAPRPIAPAPAGGRGCHRRGLSLDQGVARHQQNASMYGHEMHDWSRWLDIGDYNNHLNSGVQRPITPLQPIENMDSSLLTPATTPCWKPSTAFPRNCRTAHSSPTKRVPPPLLPRNGESMQRAKSFQGSENGYNPKQNSKGFEGPPEFRLPEPLESKMPTTDDDIFSDLTFDSLHNSDPFTLGGLPSPTMTSFSSQPEHSKETAVELPDQKAKKVPIAPASTAALPTRSRPATSSGTTSPIKAALAPRVVTIADLKLDASIDASLEETGITLEDICGYIEGPDPVDNKWICTFDGCMKRFGRKENIKSHVQTHLGDRQFKCNHCNKSFVRGHDLKRHAKIHTGVKPYPCDCGNSFARHDALTRHKQRGMCSGAFVGAVRRAERRGRPRKERPKYGERREKATRARQREKKKASSPSVQEHSSSSSAPSPESENLEAPSTREHSPVKDMLFLDMESISLPPDVFTFTPPASPSYSTGNIGSPARSYYSTSQEPDETPLCLSPSKRYLADIPEEIIEPPSFECGSPTPVKRETKKDLIGSPCRTIWPTNQGPTLTEDSNSTEFDDVFSSHASTSAFDPDQLPPLGPQSTTGISESGSSQYDDEIFLNHLNSEAPNLDSDYFPLSLSPSTDAFFDSFTTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q1</accession>
    <name>D4D8Q1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022424.1">
        <property type="nucleotide sequence ID" value="XM_003022378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q1"/>
    <dbReference type="GeneID" id="9580971"/>
    <dbReference type="KEGG" id="tve:TRV_03488"/>
    <dbReference type="HOGENOM" id="CLU_005297_1_0_1"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119303" checksum="B1A2FA8E31DE3693" modified="2010-05-18" version="1">MPLRNRKTEGQQSCRPITRKSRPATSRNRTSAAAVPPANASPASISLSESESDIERVSQKANALLGCFLSFKNHNDDASTESISRDSSVIPTKRAAEPNETSTASERSKKRDDHSSRINNRTQTQSESPPSQRASSSLYPVVEIPDRTPQSIEPPVHRHISHTSTRLKRRNTKKIEREDSPFFDCIEAPIPPASRSSRRRKGPLKYYGRTPRGCSPQNQNEENYLASKPLSPPPSSLSSVSEPLNGSGRVCYRSATHIVVRELLVDFAPEYAPYCSLKERKDLESLLKTKKHTNTSCEGALLHADLCMNELNVLYRFMRSGEKTRNEGCIQDLITEYTRQLFGCGEIEGLLQRLATLHEVKLVLSRYTADILEFLLGCRNCEMAQQIKSVKHLITICRFLKEKFLVSALVVKNDINAHLKALLQQVDEQKLRAVAEEIKILGRRASHAFRAFLIDAKNGWLSTSPSTLRAYPSKPYEHLQPYDSANVLSHIRARELGYRVYRGKASIYQTLAKSANENWEHWKSWKGASQDVVVLEWSPDGTRFVAGSATSCSPGNMMYNRRNNLVVGDLTINSLKELPDHRMPRALFDPTRANEGGSGNDSQLYTSISAVAWSNDGTRMFSSSYDRTVKVWDTSSHENTKCITTLRHPGKVLVMALSKVDNSRLATGSDRENSFLLWHVEQEYGLALSSSLEIHLRHKKLMTPTSLAWGVNSYTKDLLAAGMSLPDNTDMHGVPPIGGHLALWRMEEAGVSQVNVMPNSQNVFDISWHPTSPLFAAGIAACGRSKGLGSDIRSMVNVYDPLRGKRDIVSYDCPGIDINDVTFCPFNENYISAGCTDGTTYVWDWRNPDKILHKLKHGPPIREQDVGVQLALWGDQPNRFYSGSSDGCVKLWNIMAATEDVFVRDIANLGTDITSGALSSDKTTMLIGDTGGSIHILSTSSPQDDDKSMRFEHAGDELAGNLDSAASAANALIESGQIVRHDKFGPGKGPNYSGPYAAWARPPDTPADQLATTPLTMQVRMQQLCGSATMRRKYLDDTTYNHVRTQIQLAKYRNQKTYCAVPGSSSIITTEESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9D2</accession>
    <name>D4D9D2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diels-Alderase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000190">
        <property type="protein sequence ID" value="EFE41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022163.1">
        <property type="nucleotide sequence ID" value="XM_003022117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9D2"/>
    <dbReference type="GeneID" id="9579044"/>
    <dbReference type="KEGG" id="tve:TRV_03723"/>
    <dbReference type="HOGENOM" id="CLU_041924_2_0_1"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054499">
        <property type="entry name" value="DA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22903">
        <property type="entry name" value="DA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase C-terminal" evidence="3">
        <location>
            <begin position="222"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="42683" checksum="458D4441E5289C43" modified="2010-05-18" version="1">MQSARPIISHVKQHDPVIDGPAPQITEYKHVFFPRLACMSKTHLEAWIFDAVDLTTSNVAVTMTFFRDGTQAALGKCPIRTTFRASLPDGAKIAGELFATESVVEVIPEDGKITGKWVGGKKEDEPGDAGWAQYEVSLDMSEATVTINLPTIRGTLTLQQRSGRNIENSTESQLMGPGLSWVHSIPRAKATVDFVFIQDGESKNLRFEGYGGKDYCRSTEPMQDMMEGTTYVRGHAGPYTFALFRLFSRLHPGKTYTRATLVKEDALLFEMVSDDSVSLSDNYLSFRSTYSGKLRGNYSDHTTGYRIDFVSPGQNKHWSFELKHETLWWSMPTEAPPAKTGNNGFISTVTGGEIGEPAKQGMATIVHIQMTALKSDYKGISNRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9X8</accession>
    <name>D4D9X8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_03921</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021973.1">
        <property type="nucleotide sequence ID" value="XM_003021927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9X8"/>
    <dbReference type="GeneID" id="9578846"/>
    <dbReference type="KEGG" id="tve:TRV_03921"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="44394" checksum="02D736A0B437930B" modified="2010-05-18" version="1">MSLSNKLAITDVDLKGKRALIRVDFNVPLDSDFKVTNPQRIVGALPTIKYAVENGAKAVILMSHLGRPDGKPNPKFSLKPVVPELEKLLGRNVTFLNDCVGKEVEEAVAGASNGQVFLLENLRFHAEEEGSSKDESGKKVKADPSAVEAFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKVSGFLVKKELDYFAKALENPQRPFLAILGGAKVSDKIQLIDNLLTKVNSLIICGGMAFTFKKVLNDLKIGKSLFDDEGSKLVQGIMDKAKEKNVKVVLPVDYVTGDNFAADAKVGYATDADGIPDGWMGLDCGKESVKLFQEAIAEAKTILWNGPPGVFEFDSFAQATKDTLTSAVDAAQKGTIVIIGGGDTATVAAKFKAEEKLSHVSTGGGASLELLEGKDLPGVSALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA68</accession>
    <name>D4DA68_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021837.1">
        <property type="nucleotide sequence ID" value="XM_003021791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA68"/>
    <dbReference type="GeneID" id="9578717"/>
    <dbReference type="KEGG" id="tve:TRV_04012"/>
    <dbReference type="HOGENOM" id="CLU_2456389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="89" mass="9731" checksum="10007C314689D553" modified="2010-05-18" version="1">MQQEISQLKLFSMHVLGGERLTGRSAMISSKLWSMFDYGMVGNEAARQTGAVEKGIWSPPALQCFGNEYEDRANVAVNCAVGVDAVVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA96</accession>
    <name>D4DA96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021865.1">
        <property type="nucleotide sequence ID" value="XM_003021819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA96"/>
    <dbReference type="GeneID" id="9578747"/>
    <dbReference type="KEGG" id="tve:TRV_04042"/>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="182"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="585"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="959" mass="108188" checksum="7D180DE3334BB658" modified="2010-05-18" version="1">MEFESPEDPFELDVLQESVFFTIDPIKPLENYPWDDALPVADTYQDLTAGLFESPIHLFKHESDKVHSLNIFGDEKTEEPGPLSVAGSSSSSTKHDSQEEPMDDISDEDIWSLHNIPALSDTGYELLSWDIFPDTWKELSGPTCLSEAGPRGFDAALIHQATNTGLEDSGRVAKTDAFISSLFKLGLGWNSVFFRYNEQSRNFEKHLRDVRVSGISLPALDGLTEGILECGMWMRKLRRFVATVPAQSGSPPSLASLARVVFILLYSIEDQLSAKSKTNPSLLQTNMYFRRISCLVKCLVDIVQHATRLTADVQVVSTVFAKCDHYSHQHLWLADIFHEIMGATSSLWLHRAAQWIGLRPAGGQFNASQVFDPGYLDEYTTEETIFNPESMPSFIPREDADVIYETGVGLNLLRSSHKGHPLAEVHQKENTSSLTLEWGLTWEDINNIQLKAKCYETCLRNEILKYNGAIGKAGEGSATPKEYTFDYPQEINITIDDIYKIPGSEDWLGSQSESMSDCQMRSSRLYELVKEGSCVNIEKSLIAEHTFGPPLESAPSLSFAPVILAQSRLVNFSCLHLLFKVHKVRDHLQVQERFQLLGNAEFLLRISLALFDPNMHSGERKSGVARGGSSTGLRLGNRNSWPPASSELRLVLTGLLSECYEGNSNGEQQHPGGPSSRELPGGLSFSIRELTGEELERCKNPHSLEALDFLRIHYTPPSPLEEVITPLSLEKYDIIFKQLLRLIRMLSVVRDLVRSPPGQQTSSVGTLEQRFRVEAFHFVQVVSDYSFQVGINHPWQQFDKRLSKIERCIDEGDVEGTITHAKGLRRLREYHERVLDRIILALFLNKSQLKARNMLEDVLRSILAYSFHVKAYQERLDIATAAGLMPSSKTTAYYNRSIRELYSRFKKQVGGFIRFLRSLEAGGVKNMIDHDDDMDASADIDLNSIFEHLLLRLDMNEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAB5</accession>
    <name>D4DAB5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000206">
        <property type="protein sequence ID" value="EFE41196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021814.1">
        <property type="nucleotide sequence ID" value="XM_003021768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAB5"/>
    <dbReference type="GeneID" id="9578706"/>
    <dbReference type="KEGG" id="tve:TRV_04062"/>
    <dbReference type="HOGENOM" id="CLU_004137_7_6_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="29" mass="3743" checksum="63152971817EC335" modified="2010-05-18" version="1" fragment="single">QKQSKKKKEGQQQQQQKKKRKRKKKREQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAF1</accession>
    <name>D4DAF1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-230 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021767.1">
        <property type="nucleotide sequence ID" value="XM_003021721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAF1"/>
    <dbReference type="GeneID" id="9578647"/>
    <dbReference type="KEGG" id="tve:TRV_04098"/>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="36305" checksum="518CBAF965656FBE" modified="2010-05-18" version="1">MAPPPTATLTETVASVGNVVRDNFAGEGNTLAQAAPEAGSGSGSGYALLDDFAGKWEEFKFAPIRESQVSRAMTSRYFKDMDTYAESDIVIVGAGSCGLSTAYVLGKARPDLKIALIEASVSPGGGAWLGGQLFSAMVLRKPAHRFLDDLGVPYEEDASNPNLVVIKHAALFTSTLLSKVLSFPNIKLFNATCVEDLITRPRASEASGFQIAGVVTNWTLVTQHHDDHSCMDPNTINAPLIISTTGHDGPFGAFCAKRLVSMSALEKLGGMKGLDMNSAEEAIVKNTREVTKGLIIGGMELSEIDGWHRMGPIFSAMMLSGLKAAEVALEVFEERKKECSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAF6</accession>
    <name>D4DAF6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04103</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021772.1">
        <property type="nucleotide sequence ID" value="XM_003021726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAF6"/>
    <dbReference type="GeneID" id="9578652"/>
    <dbReference type="KEGG" id="tve:TRV_04103"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="39"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="236"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="498"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="602"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="709"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139078" checksum="5FE43EF3FA2AA735" modified="2010-05-18" version="1">MGGKSDADWSVEYDTLRRERLFRHPPKDKTAYPALAAAIRPHIDSFNALFEDTKVLEAALKDIGIKSFIDGSSETPEEKASRREDGRRAPKRNKLSVRITELFLEKAVLPASNKYSTRNREIYPAECRERHATYRGRLRARLEYRINNGEWKESVRELGQVPIMIRSNRCHLEKATPSQLVDHKEESEELGGYFIVNGNEKLIRMLIVGKRNFPTAIIRNSFQKRGSAYTKFGVQLRSVRPDQTSQTNVLHYLNDGNVTFRFSWRKNEYLVPVVMILKALIETNDREIFERLVGREGSLGIENTFVTDRVELLLRTYKAYGVHSRSKCRAYLGSKFRFVLGMPEDIPEEDVGTELLRKIVLPHLGNQNVTETQDNDKFNMILFMIRKLYNLVAGDCAPDNPDAVSNQEVLLGGYLYGMLLKERLEEWLKSVGPMVRDWRMRNQDAKFTDPKFEREFLTRIIGRTNENIGGAMEYFLSTGNLVSPTGLDLQQPSGYTVMAEKINFYRFISHFRMIHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCLISTSNLDVSGIPGVLAGLGVTSESSCSIEESIPVQLDGKILGYCTPKQSRAIADTLRYWKVQGHKQIPVELEIGYVPSSNGGQYPGVYMFSEAARMYRPVKYLPLDKLDYVGPFEQPYMEIACVASDIRNGVSTHIEFDPTHILSILANMTPFSDFNQSPRNMYQCQMGKQAMGTPGTAIDYRTDNKLYRLQTGQTPVVRPPLYNAYGLDNFPNGMNAVVAVISYTGYDMDDAMIINKSSHERGFGYGTIYKTKIYALDDKESRGRGKSKRATTKLFGFAPGGLVKAEWKAQLDEDGLPHIGAKVSEGSLVGAWHTVQYDPATDTYINVDKQTHFLKYKDGEEGFIDSVRVLGSETGNEVCQAVSIKYRVPRRPVIGDKFSSRHGQKGVLSQLWPATDMPFSESGIQPDVIINPHAFPSRMTIGMFVESLAGKAGSLHGLPQDSTPFQFSEEATAGDFFGKQLQRAGYNFHGNEPMYSGITGREFAADIYIGVVYYQRLRHMVNDKFQVRTTGPVNALTGQPVKGRAKGGGIRVGEMERDALLAHGAAFLLQDRLMNCSDPQRAWICRTCGSFISTQVAVSQLLSPHKNPAMDAVVQSTASAIAKPLSGVSALGGLAGIVRCRRCAREAVFDDPRAEVWEDGSGKRYVGGSDTTVVAVPGVLKYLDVELAAMGIKMRFQVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV9</accession>
    <name>D4DAV9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021627.1">
        <property type="nucleotide sequence ID" value="XM_003021581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV9"/>
    <dbReference type="GeneID" id="9578588"/>
    <dbReference type="KEGG" id="tve:TRV_04257"/>
    <dbReference type="HOGENOM" id="CLU_029631_2_0_1"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="503" mass="55110" checksum="D56D6249ECB2008A" modified="2010-05-18" version="1">MGCILTSRNGPLPQHVQLRTFTGAVRYLQNDTQLCPRYLRKSYFSSHDPLTSSELRPRSFLPWSRSVSSTQQTGALFSSKAPTTYTSTDEPISIPQSTAEAVQELPHRRRQRLKAQGGTNSSEQELRPDASSQLSSISSSLPKSSLKGKLAAFLALTKPRLSFLIVLTATTAYGLYPVPSILHLDPTVTPLPTLSTSTLTFCYLTVGTFLSSASANTINMLLEPKYDALMSRTRNRPLVRKLMSTRAAVFFAIGTATAGLTALYFGTNPTVAGLSAANIILYGFIYTPLKRISVINTWIGAVVGGIPPLMGWAAAAGQTAITGHDTWKDLLFGPESVGGWLLAGLLFAWQFPHFNALSHLIRDEYKNAGYKMLAWTNPARNGRVALRYSLLMFPLCAGLWWAGVVDKGFLIGGVLINSWLTREAYRFWILEGAKGTARGLFWASVWHLPLLMVGTLAAKKGIWDGVWSRAMGYAEDDEDLDAEEIEETSDVLPPLPTSRVQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAW3</accession>
    <name>D4DAW3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021631.1">
        <property type="nucleotide sequence ID" value="XM_003021585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAW3"/>
    <dbReference type="GeneID" id="9578592"/>
    <dbReference type="KEGG" id="tve:TRV_04261"/>
    <dbReference type="HOGENOM" id="CLU_013694_3_0_1"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="394"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="603" mass="65270" checksum="F0E26A36EB10E09A" modified="2010-05-18" version="1">MAEPSIPFDGPRSRAPTFPRQPEELHMPSANASSKPQNEQQQQHSSIPPLLSIQQQPGPQQQQQQHQNNALPGALQPGPASRQGQPSTTHHNSSNNIHNSSSSSGVPSQLAVPMTPSKQSSMSQLQSYPSSPGVDQQRYQHHQQQQQQQQQSSMMSPSGQSSSTPYSPLGLADIRPHMDLGRIDDSAGSSTIHNGDMHTPKNSSYLAPWALYALDWCKWPAAPNTNSAGKIALGSYLEDTHNYIQILHAQTAERDYNDPDNDPGLEFVKTAEATHSYPVTRILWEPPSSQKQSTDLLATSGDHLRLWSLPSNPSQPQYYGSNSINRMSASNKSPPPLQKLSPLALLSNSKTPEHTAPITSLDWNAVSPSLIITSSIDTTCTIWDIPTLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGADGSVRMFDLRSLEHSTIIYEPSEKHDKASPHDAHLLATFAQDSNIIRVLDVRQPGQALLELKGHAAPVNCLEWSPSRRGTIATGADDSLVLIWDLINQNNAAALPLPPQQPQGLHSGGNGNSSNSTATSTSGNGPSTLERGPAAAWRCDYEVSNISWAPHIPATGPGRDWVGVCGGRGLWGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB02</accession>
    <name>D4DB02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021592.1">
        <property type="nucleotide sequence ID" value="XM_003021546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB02"/>
    <dbReference type="GeneID" id="9578553"/>
    <dbReference type="KEGG" id="tve:TRV_04301"/>
    <dbReference type="HOGENOM" id="CLU_101888_0_0_1"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000005">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="20219" checksum="E53F570B52D6F7FF" modified="2010-05-18" version="1">MPQITNYRTIDIDSLDPESPANFPISSLLPSNLPPPTTSSAAASLASQIRQLLRSGDTEGALRHVLDSAPLGGDDRAKEVHLASVVEVLQGIRQTEMTKVLEAVCNGEGGAERGDCLMKYLYKGMAVPTSSDAGSKSVSPQSTGFSQIQGRNLGEGGGGQQMSVLLSWHEKLVEIVGVGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB48</accession>
    <name>D4DB48_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021500.1">
        <property type="nucleotide sequence ID" value="XM_003021454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB48"/>
    <dbReference type="GeneID" id="9578448"/>
    <dbReference type="KEGG" id="tve:TRV_04347"/>
    <dbReference type="HOGENOM" id="CLU_000998_3_0_1"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="466"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="708" mass="79115" checksum="5E65BF86B9057339" modified="2010-05-18" version="1">MEMEAPRVAASQEPAPATNTQPAETEVASAREMLAVPEDAVQVLCGPLLNYKHMGPDASSRQVWNGSVLIVTRPREQPPLLQLQCLGAVSNVNGPTAGAGSVEPTVEGVKLFSSPIAAFWRFRIAVAMEDYEARWQYTIPGFRHVDQEHTMSSWNFVVPAVNDSMRIMFHSCNGFSVGTDLGHWQGPLLWHDILRLHAQRPFHVMIGGGDQIYNDSVRTEGPLKEWTNITNPHRRRAHPFPNTLRAECDVFYFNNYVRWYGTEPFATANAQIPQINIWDDHDIIDGFGSYTDHFMRCAVFRGLGGVAFKYYCLFQHHNAPPMSTFTTDAPQTMQAGEDGTSGIDQRQLEGCYVYKEPEDEPGWIVGSKPGPYVEEISRNLYMRLGKRIAFAGIDARTERTRHQVNYPETYDAIFARLEKEFTAAKGEIKHLILLLGVPIAYPRLAWLENILSSPLISPIRLLNKRFGLGGSFFNKFDGQVDLLDDLDDHYTARQHKAERRQLIQRLQQLAARYSVRVTILGGDVHLAAVGRFYSRVKDRVPIDSDPKYMINVISSAITNKPPPKAVANLLASRNKIHHLDPHTDETLMKIFNDQPGGKEKSSSSNKVTMPSRNYACITEITTSNEQPELAKAPKDGHDALHPGEQDAGTEYRSADGVSNVTGKLGGLDIAIRVEIDPADIEGKTEGYGFSGMSFHLTLHFLFSQLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG9</accession>
    <name>D4DBG9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021395.1">
        <property type="nucleotide sequence ID" value="XM_003021349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG9"/>
    <dbReference type="GeneID" id="9578274"/>
    <dbReference type="KEGG" id="tve:TRV_04469"/>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="784" mass="87497" checksum="02A5FF5F235E8EA0" modified="2010-05-18" version="1">MDLTSWPQVVAINQKNYYTDYLKRDDQFLAYRLQNEENRNRMAKAAKERDRALAMSKQNELPLPEEEADQDTTMGEAGNEEEEAVAGSKTIVVHVGSQNLRIGLASDALPKTIPMVIAHRSEMNESEENGGEPKPKRLKMDDGELMEPEKMFGPDFGTLYTNMCSDLKARMRQNKRRTLPNSKEMVVNYNRRTPPETISEHNDAMRVEWTEIPSNPNLAPPYVVGEAALRIPDLSIPRYKLYWPLRNGWCNEKDYSSINLLFLDIARILEDAMKTQLNLSQTKDWGQYSCVFVIPDLYEKLYVTQILDTLMRELGFGRVCFVQESLAGTFGAGYTAACVVDVGAQKSSICCVEEGMCVENSRVNLKFGGSDVTETFIKMMLYDHFPYEEINLNRRYDFLLAEELKKNVATLNETNVSVQVFDFHLRVSGQDTRKYTFKAYDEIILAPMGIFQPEIFDNSQKMIGRRKFIKRSFDLYDRLPNDPTSTAQAEVIASISPPPATTNNGTSIEGALQTNGTDPQATPSRTQAHNVIGRVQDLDGTPRSSAAGSPTPDSAANQNPQGGTSTPIRPQGGGVPNAPSTSQNLPVIEMRDDVLPVWPLEDAVFTSISHAARGDPRKFNDFIGGILVIGGGSLVSGFHAFLEERMQLKHPDLASHIMVGTPPRELDPQVVVWKGASVFGKLDASNESWIGRLEYDRLGSRVMTYKFGQFSQAFLLLFSFEMSSSFDIPGLCNTGLRCQVYPKGGDGTGPAECQLLVHRETAQKAKAKKDDEEEELAILLSTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH1</accession>
    <name>D4DBH1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021397.1">
        <property type="nucleotide sequence ID" value="XM_003021351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH1"/>
    <dbReference type="GeneID" id="9578276"/>
    <dbReference type="KEGG" id="tve:TRV_04471"/>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="406" mass="43786" checksum="49C9206A1F182FFA" modified="2010-05-18" version="1">MTTNTQQGGSSKVVDPIADVELCKRDIKYFKELGLNTIRVYTIDNTKNHDECMKLLADAGIYLVLDVNTPKYSINRADPEISYNAVYLQSIFATVQMFAKYDNTLAFFSGNEVINDGKTSAVAPWVKAVTRDIRMFLKERKLRQVPVGYSAADVDSNREQTAHYMNCGSDDERSDFFAFNDYSWCSPSSFETSGWDQKVKKFENYGIPIFLSEYGCNINKRDFSEVEALYSKEMTGVYSGGLVYEYSQEPSNYGLVEIKGGASSDPSKLTDFNALKTMFAKVKNPSGDGGYNQKSGSSKCPAKEAPAWDVDGEKKLPQLPKDAEKYVKNGAGDGPGLKGPGSQSSGSKAEGPDTSGNGNTGSGGSPGSGGNKGTPDAAAGLRAPEFVVVLAAIGLSTLVGASMMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC87</accession>
    <name>D4DC87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanGTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021125.1">
        <property type="nucleotide sequence ID" value="XM_003021079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC87"/>
    <dbReference type="GeneID" id="9577997"/>
    <dbReference type="KEGG" id="tve:TRV_04739"/>
    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75075" checksum="F2B94A736DAD878F" modified="2010-05-18" version="1">MLIYSRSGIAITATYAIRQSSKLLKVSYLFASAYPILPVDGAEREELRSLKIRLQSKIQIISPAIDMIELIAARGNTSLESAVNLTKTLRLDIQNLGQRLARVVGNEEAHGKGASAKRRAQLDAEINSVIREIRTLLDRIEDAVPLINLAITTSGARLSTTLPSTVSPSRLLQASTFLTAGDTQFSLTPNRSVQVGPTFTLSIYLLFAGHVRPTDEEGIRETTWKEVIHKARVKLCRVPIDVVLADQYGDQRNLRGEARADEFAYQILIIEDLDDGRVHSFEDDEPKPGPFEGVAQAGIRDVIPVHQISKIFYADTGKILNIGTEGEANNPVLLLKRDINAIPPRGMIEREDLAGYFDPEDNHDHEQEPYDDEQAQVNAQLMASQGIHNPSDPVQYQNDIPEHWRFPPSLDLEWIALEVHQEEPESEDDDNEEDEPEAASATITEEDELSENLAKLRIPNKHESSSSHVAVPLSPDHPMSSSTVSNPLFNNIRTSLSLLETLLRLTSLQQFQQQSHLSITDELLTFFLEESSATGAGGDEQHRQRVRSEARRKVGWDPYDESPLKPRGEDYQYQNEHGSVASTPSRYQPQSVDTDEGFGEIPAQTRSKYVGRYQDSPQVRGQRESSQALSPTTPRPLTPASPSPKENYPENNDRKPSSLRRQVPTNKQAKNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCB9</accession>
    <name>D4DCB9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000242">
        <property type="protein sequence ID" value="EFE40505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021123.1">
        <property type="nucleotide sequence ID" value="XM_003021077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCB9"/>
    <dbReference type="GeneID" id="9577964"/>
    <dbReference type="KEGG" id="tve:TRV_04772"/>
    <dbReference type="HOGENOM" id="CLU_019317_3_1_1"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="111"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="53748" checksum="75EA0B5477E74FC3" modified="2010-05-18" version="1">MSRRPTDVANKERNEYIPSFISKKPFYVDDDSSANDYLEHQRLHKEKEDQKWYDRGKRVGPAATKYRKGACENCGAMTHKAKECLSRPRKHGAKWTGKDIQADEHIQKVELGWDAKRDRWNGYDAKEYQNVVEEYEELEALKRKAKDNASKEQKAPGEDGDDDVDGDGDGTSEAKYAEESEMGRQQGKGTRNLRIREDTAKYLLNLDLDSAKYDPKTRSMVDMGAQSDQVAALVAEENFMRASGDAQEFEKAQRYAWETQERGDANRQHLQANPTSGEYYRKKQKAEMDAKKAADKKALLEKYGGGEHLQAGPLRDMAVIENERFVEYDETGAIKGEPKPAAKSKYAENVLINNHASVWGSWWSNFTWGYACCHSTVKNSYCTGKEGIEAFEQAQNMLQIEAGDDDQKQAPAKDTMEDKSADEGRNKPASNAQKKRSRHELEMGVTEEELEAYKKARTAVADPMAAFLGKDELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI1</accession>
    <name>D4DCI1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021060.1">
        <property type="nucleotide sequence ID" value="XM_003021014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI1"/>
    <dbReference type="GeneID" id="9576707"/>
    <dbReference type="KEGG" id="tve:TRV_04836"/>
    <dbReference type="HOGENOM" id="CLU_749994_0_0_1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="41838" checksum="C80F14DDE8382942" modified="2010-05-18" version="1">MFKGPDDIYLTFTYEDYNTLKSDWLTDNVIGFWEEYLEHELLSFYKTRIILLRPSMSFLLFQTPDPKTLGNALPDFSRASHIFLPINDCQNGMQAEGGTHWSLLLVSLADQVAFHYDSLPPGNITEAHAVTEKISIICEKPIKFMQMPDCPVQQNNNDCGVFVCMMMRYLLQHRLLQANSKEYITMALDGVPLDPAEARKEIVQIIHQLKRDRDRRRSYVTSSADPAAASRIFAKPHSIIARTQSSPAHRTPATASSADSPASTRPRHSRVSLFTYFAICASVIVLIAAALAFYLPDINMTSLYHGYTHIQSPVCGEYCHKLDSALSSARSQLSPYLLQMHEQLNELHDFGREYFAKVYDAFSRLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCK1</accession>
    <name>D4DCK1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020991.1">
        <property type="nucleotide sequence ID" value="XM_003020945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCK1"/>
    <dbReference type="GeneID" id="9577843"/>
    <dbReference type="KEGG" id="tve:TRV_04856"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="147"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49192" checksum="76E9A3DF1BDD6E06" modified="2010-05-18" version="1">MAASTRIPSLIQPFVSERARKTLDIVEEFVEKECIPRDTLFQAQLGEGQARFTKHPPVIEELKAKAKKLGLWNMFLPKNHFKEGAGFSNVEYGLMAELLGKSRVASEATNNAAPDTGNMEVLAKYGNEAQKREWLDPLLEGKIRSGFLMTEPDIASSDATNIRLNIRREGNEYVLNGEKWWSSGVGDPRCKLYLVMGKTDPNNPDPYKQQSVVLVPAGTPGVTIHRMLHVYGFDDAPHGHGQVSFKNVRVPVSNIILGEGRGFEIIQGRLGPGRIHHAMRALGAAERALEWMIARANDENKKPFGTPLSSHGVILEWIARSRLEIDSARLVVLNAAARIDSADAKAALKEIAEAKVLAPQVALTVIDRAVQAHGAMGVCQDTPLASMWANIRTLRIADGPDEVHLQQMGKRENKQRKNSTMAKIKAQKAEADRLLNANGFGALKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCS4</accession>
    <name>D4DCS4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000250">
        <property type="protein sequence ID" value="EFE40350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020968.1">
        <property type="nucleotide sequence ID" value="XM_003020922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCS4"/>
    <dbReference type="GeneID" id="9577820"/>
    <dbReference type="KEGG" id="tve:TRV_04929"/>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="35836" checksum="BA8003BC7B46E6E0" modified="2010-05-18" version="1">MDLKPGVTAGEEPELPIPISLIAGRYFLFSIDAVTYLRREHHICGVLVGTLPQVPQQNVFLGLPLELMPEEARLLVEKDVAYVVDDTQAHTQGITSLQEEDKRRYLNELKQKGLQATLILADKKAERREIALKRQKDKEVKKSKRKIGGEKAEVVEGDTPSHVEPETEIDDGDGDDELLFAPPKRPAVAGDTASRACGEQILEVTPATSNGLLPRAAPRAPPYLPEAPSSYPLFAHLHSKGYFLSPGLRFGCQYMAYPGDPSRFHSHFLVVSTKWEEEFDLMDLAAGGRLGTGVKKGYLIGGTEKSDDEGSEQVVRTFSLEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV3</accession>
    <name>D4DCV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000252">
        <property type="protein sequence ID" value="EFE40318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020936.1">
        <property type="nucleotide sequence ID" value="XM_003020890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV3"/>
    <dbReference type="GeneID" id="9577790"/>
    <dbReference type="KEGG" id="tve:TRV_04958"/>
    <dbReference type="HOGENOM" id="CLU_013399_0_1_1"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="6">
        <location>
            <begin position="152"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="57196" checksum="8C4969B826928ECD" modified="2010-05-18" version="1">MTLGRFFSDSRDAGREEDAEMQAPRDEASVLPVGVNALLTLTTDSLIIQGKAIPGCHSYFFFFLSLICHIHCHILYIFLKYISVARVTRSIPFFNILWAEISDNHININYANPRNKLDVGLATVCYSIERTQLSRAETWAASLLDLAYGEAQKKKRIKVLVNPFGGKGNASKIYYKEVEPIFEAANCVIETQITEYSGHAIEIAEKIDVDAWDVIAAASGDGSIFEIFNGLGKKENAGEALAKLAVAHIPCGSGNAMSRNLNGTAGPSMAALCIIKGLRTPLDLVSISHGQRRTISFLSQAFGIVADSDLGTDNLRWMGPARFTIGFLIRLFGNTVYPCDVALKVEIDDKKRIKEHYNAVVQNKSNAEPREEIPESGGLPPLRYGLATDPIPDDWMRISHDKLGNFYSGNMAFMSQDANFFPASLPNDGFLDVIMIRGDISRLTAVQMLGALEDGELFDLPDVHALKISAFRITPRNPEDGYISIDGEQIPYEPFQAEVHKGLGTVISRSGFKYETGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDD8</accession>
    <name>D4DDD8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_05147</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000262">
        <property type="protein sequence ID" value="EFE40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020764.1">
        <property type="nucleotide sequence ID" value="XM_003020718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDD8"/>
    <dbReference type="GeneID" id="9577463"/>
    <dbReference type="KEGG" id="tve:TRV_05147"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_0_1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="32167" checksum="9BD9594A9E43B569" modified="2010-05-18" version="1">MLSLLNGFFIPSASRLSRLILKKPNPGIIHRLSHPNAAPPRLKSHISRLNSVHKRCSTAASSSNDSKTQHHGNNITNNTDGPRGRSRYSFGRNAALDTFLFTIQGLALFIVFREHVLDVKWISGASMSPYLNKGYNIDNIDSEMVLVDVTYATKLHLKRGMVVVFPTEPSKLSVKRIIALPGDVVTTRPPKSGEGDQKTQIVPWNHVWVEGDATDPDLSFDSNTYGPISMGLIKGQVMCVLRPKWRTLKWWEWENENDPVESGGDYGKSQRMRVKKDAVTVYDPNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE60</accession>
    <name>D4DE60_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored cell wall protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020460.1">
        <property type="nucleotide sequence ID" value="XM_003020414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE60"/>
    <dbReference type="GeneID" id="9584199"/>
    <dbReference type="KEGG" id="tve:TRV_05426"/>
    <dbReference type="HOGENOM" id="CLU_110345_1_0_1"/>
    <dbReference type="OrthoDB" id="4174295at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055798" evidence="2">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="172" mass="17020" checksum="956A254FBF900EF1" modified="2010-05-18" version="1">MLARSVLAFLFLALCSVVAALPPACLLEVVSANGHPGDFDTLCGSGSDGVQKEIAQKCGSNTKEALQSYKQSCGEAGFKITLIHANTTSSSSPSQTSSISGSGSMTTGSGTAPTSGSGSRPSSGSGSKPSSGMGSSPTSTSPPYTESNVGSLQKADSVFIALVFAIVGALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE93</accession>
    <name>D4DE93_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000288">
        <property type="protein sequence ID" value="EFE39822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020440.1">
        <property type="nucleotide sequence ID" value="XM_003020394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE93"/>
    <dbReference type="GeneID" id="9584179"/>
    <dbReference type="KEGG" id="tve:TRV_05460"/>
    <dbReference type="HOGENOM" id="CLU_010595_2_3_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="316" mass="35478" checksum="54141076C54CEC67" modified="2010-05-18" version="1">MFPNDEQENERLDIHHALIDTLLHGRLHIAPISKDPQRVLDLCTGTGIVRASTYMSYNQLFAFTNPSSQWAISFGNITPLPPLSNGSGYGLTGLSIKPMNTHQLRERSKPYSTFSVCISIPTPSSISRLHADSVPPNLKFIVDDVEDEWGYEGSPFDYIHGRFLIASIRDWPRLIKQAFTPRLTKQTSSCTKPGGWVEFQDWDGTIRSDDDTLKGTHLFQLQETVKEAFIEMGINANPGAECGSWLKDAGFINITTQDKHLKTVGAYNLLQHTKGLGGIANLPLIKKGWQPEEIEVLLSKTREDLRNRSIHAYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEK7</accession>
    <name>D4DEK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05574</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000299">
        <property type="protein sequence ID" value="EFE39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020330.1">
        <property type="nucleotide sequence ID" value="XM_003020284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEK7"/>
    <dbReference type="GeneID" id="9584073"/>
    <dbReference type="KEGG" id="tve:TRV_05574"/>
    <dbReference type="HOGENOM" id="CLU_1120801_0_0_1"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655216" description="Sorting nexin-3" evidence="14">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="248" mass="28499" checksum="9B58213FE4ACB7E4" modified="2010-05-18" version="1">MVFFLLFAAANGSEAAEGTSRKPFSTPTSQSIRHHRKHSSSEKQQKKKKKKKSRQLTEELPDFRLSSPEPCDLGHYPRLSSLAACHTRPQVDIKVFNTHHQPISGSKMQAIPDARHQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVVGHPLLQTGSKVLASFVQGKYLPLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEW6</accession>
    <name>D4DEW6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000313">
        <property type="protein sequence ID" value="EFE39605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020223.1">
        <property type="nucleotide sequence ID" value="XM_003020177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEW6"/>
    <dbReference type="GeneID" id="9583994"/>
    <dbReference type="KEGG" id="tve:TRV_05706"/>
    <dbReference type="HOGENOM" id="CLU_064752_0_0_1"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="39922" checksum="8BFC286F2AB178B7" modified="2010-05-18" version="1">MSLASSAPPRPALLNKTTNALLSPRKHNSASSMGSDDNVSKQVTRNHTPSSPIQLVGKKRSIDQVDVDQYRPSTAASSFNSQNRREDEFYIYDESTHSSMDIDKETSFLQYSSHNKASDSQEQAAEKGCSQESTSISSLLNLSFESEGGNYSNNRNINNAKRNSPLSSPNPPQKSTRGQTISSSSSIPTDPEARKLFIQQKAGLLREKVQTAMKNIRDHSEMDRRIKELEALCPQAWNTANQQATPSSSHSETRSDLAPGVQQGPSVASFGQNNDQKGGDYAATPTQQNMNQQPQVPLPSQPAGNNQPVQPQSVNNAATVPVIQKEKTTVDRKALRVNHEIAVDGLLRLMKTTSEYDALDEWAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEY9</accession>
    <name>D4DEY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000316">
        <property type="protein sequence ID" value="EFE39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020202.1">
        <property type="nucleotide sequence ID" value="XM_003020156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEY9"/>
    <dbReference type="GeneID" id="9583972"/>
    <dbReference type="KEGG" id="tve:TRV_05730"/>
    <dbReference type="HOGENOM" id="CLU_191686_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="86" mass="8864" checksum="7DA0A1A1A7A9E4BC" modified="2010-05-18" version="1">MSCRSSEIPVLLRFAAGCQLVVNPMLASPLSHGLTTARKPSSASSMDEPASYPVSSLAGFIVACCLLVVVVVVANVNAIPGQRLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFK4</accession>
    <name>D4DFK4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019986.1">
        <property type="nucleotide sequence ID" value="XM_003019940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFK4"/>
    <dbReference type="GeneID" id="9584740"/>
    <dbReference type="KEGG" id="tve:TRV_05955"/>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001680">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit (Pwp2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="776"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="931" mass="102520" checksum="3DED2DFF82CE91D0" modified="2010-05-18" version="1">MKTDFKVSRLCAVTACSSLLISRQFSNLLGTVYRKGNLLFTPDGSCLLSPVGNRVSVFDLVQLRNTSYTLPFAHRTNIARIDLSPRGNLLLSIDENGRAILTNFPRRLPIHYFTFKSAVSALSFSPSGRHFAVGVGRRLQIWCTPSTPGSGTSGELEFAPFVLHRDLAGHFDTIQNIHWSSDSRFLLTASKDLTARIWSVDPEEGFEPTTLAGHRDGVINAWFSHDQESIYTISKDGALFRWGYVSRMKEDGSSTDERWRIVKKDYFLQSGSKVNCAAFHAKANILVVGFSNGIFGLWEMPSFSQLHLLSVSQSNIDCVTINSSSEWLAFGSSKLGQLLVWEWQSESYILKQQGHLDSMNALVYSPDGRKIITAADDGKIKVWDIKTGFCIVTFTEHKSGVTACEFTKRGNVLFTASLDGSVRAWDLVRYRNFKTFTAPSRLSFSSLAVDPSGEIVCAGSLDSFDIHIWSVQTGQLLDQLSGHEGPVSSLSFSADGSHVVSASWDRTVRIWSIFGRSQTSEPLQLQSDVLCVAFRPDGKQIAASTLDGQLTFWSVEDAVQQSGIDGRRDVSGGRKITDRRTAANSAGTKSFSTITYSGDGTCLLAGGNSKYICLYDVGTSSLIRKFTVSLNTSLDGTQEFLNSRNMTEAGPQGLIDETGEASDIEDRKDKTLPGARRGDDGARTTRPEVRVTSVSFSPTGRSFCAASTEGLLIYSLDDDVVFDPFDLDISITPDSIMATVAAAKKAALSQPSDFSSETTTSDSSFLKAIIMAFRLNESELIRTVYESIPPSEIPHIVRSIPTVYVTRLLRFVANAADETPHLEFNLLWIQALLSIRGRYIKNNAASFAAELRSVQRAIDGIRNDLKRLAEKNSYTLEYFLSKPAYAPGAKNITSNESNRLLLENPKEENTSMEEQGEEEANDSDGDWIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGA7</accession>
    <name>D4DGA7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000349">
        <property type="protein sequence ID" value="EFE39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019748.1">
        <property type="nucleotide sequence ID" value="XM_003019702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGA7"/>
    <dbReference type="GeneID" id="9583671"/>
    <dbReference type="KEGG" id="tve:TRV_06211"/>
    <dbReference type="HOGENOM" id="CLU_057752_5_0_1"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="37369" checksum="DA17B764AE945178" modified="2010-05-18" version="1">MSGKGSSAGSRIKAGSSSLMPSSSKPEFPFKQILEDLFRDGSYSDMEIVCNGFTFKAHRAVVCTQSEFFSAAFKSDFKEAKSRTVELPDDDFETIERVLSFLYLQEYDENGHLMALDSKAIVPSSSTDGSSAKDEKRTRTTDAGLNNVRVYVAADKFGIPLLQSLAAEKFTRWANSNWDSTEFLRDIEEIMTITPPHDRTLRDILADVISKNLQLFAANKDFLALIENFGGLGSAILFKLVDSDLVKAPEPQKLFSPTSTSFGKTNSTTTGNFVVVHAVHGIDVKTIHSSSEWLIVIGSGSGIFLPKSFLYFLAKMYDIVTPLLLSRHLPAEEPQLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGK3</accession>
    <name>D4DGK3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019678.1">
        <property type="nucleotide sequence ID" value="XM_003019632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGK3"/>
    <dbReference type="GeneID" id="9583566"/>
    <dbReference type="KEGG" id="tve:TRV_06307"/>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="413"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="483" mass="50245" checksum="8A9C2356CFE971D7" modified="2010-05-18" version="1">MSASPTSAGPSTKRPLEDPSSPSGPNDQPEAKRQALDKVVKAEGDESKSQEGDKPTNEKSVNGTENGAGGENGVKDGQGDLLVPDAPNNGKTAPAPALETQPIQSTASHNDRATSNPPTTSQPAQDETGWVHIRAVISSAEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGMQDAVAKAFGLIIRTLNNEPLEAPSTAQSKTYPLRLLIPHILIGSIIGKSGVRIREIQEASGARLNASDSCLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGVVPGGMQVVPYVPQPAGGQYGHPDSLRRNNPQANRAAPGGYGVPYMQQPAPHPHAPQPSLHYGASPRTGYTGAGPHQPAPYGAPQPLHGGHVPPNGPPMGAAVPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQDNSNERLVTITGTQECNQMALYMLYSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH78</accession>
    <name>D4DH78_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019453.1">
        <property type="nucleotide sequence ID" value="XM_003019407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH78"/>
    <dbReference type="GeneID" id="9577903"/>
    <dbReference type="KEGG" id="tve:TRV_06533"/>
    <dbReference type="HOGENOM" id="CLU_2484952_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="87" mass="9831" checksum="1FBE362EF9E0AF36" modified="2010-05-18" version="1">MESAEDVVATALDTVKSAALTPTEHLLLKRFLDKAQDSSCAAIYLLRKVEENPSRSVEANLREFKKDWRRLVTKCKAPVDNTIQIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB4</accession>
    <name>D4DHB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019403.1">
        <property type="nucleotide sequence ID" value="XM_003019357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB4"/>
    <dbReference type="GeneID" id="9580119"/>
    <dbReference type="KEGG" id="tve:TRV_06570"/>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="460" mass="50601" checksum="8B0201C54E206F8B" modified="2010-05-18" version="1">MLPLPCAPDSSWSRFRQQLAAVFNGVDPRVFTAFWLFGLINNVLYVIILSAALDLVGPSVPKGVVLLADVVPSFFTKLCAPYFIHIVPYPIRILIFVALSTLGMFLVALSPAYDATTANSSITAKMVGVMLASLSSGGGELSFLGLTHFFGPFSLAAWGSGTGAAGLVGAGAYALATTSFGFSVKTTLLASALLPAVMVISFFGILPRGPMLQIRNGYQTIQEVERGELRRDDVRRPLDDERSSHTNDGSDGLLADTDNVDDLKHAPPQDKGLSWQLFKANLNRAKSLFFPFMFPLLLVYIAEYTINQGVAPTLLFPLQESPFKHFRAFYPTYNAIYQVGVFISRSSTPFFRIHDLYLPSFLQVFNLGLLTLHALFNFIPNVYIVFLIVFWEGLLGGLVYVNTFAEITDRVPKEEREFSLGATTVSDSAGICIAGMLSMVFEVWLCNWQVSHGRDYCKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ1</accession>
    <name>D4DHJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019303.1">
        <property type="nucleotide sequence ID" value="XM_003019257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ1"/>
    <dbReference type="GeneID" id="9577625"/>
    <dbReference type="KEGG" id="tve:TRV_06647"/>
    <dbReference type="HOGENOM" id="CLU_000288_44_0_1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="838" mass="92071" checksum="5CADF483DE8471BA" modified="2010-05-18" version="1">MDGDLSLSQSLGGLRIANPDNASTNTSEGPSISSLKLSSMGQDAPEALAAPEHSQPGNRSVDTGPSPAPQASASNVNLHDYSRNSPSQLPSNVQLNMSHHPSRQSVCLPPNHQPSPRGEPYRLRTDSSVSATEYPSRIDSRGGSTALQAGVLPRDEGHTDRSYAPTKVFRGGAPLPPRQSSRRAPSTSIPAVSTSYGNENAPLHSSEEWQERGAAVGVQQEIDANGKPVARYVKKGVRDFVFGRTLGEGSYSQVVAATDRQTLKEYAIKILDKRHIIKEKKVKYVNIEKDTLNRLTDHPGVVRLYYTFQDERSLYFVLDLAGSGELLGVLKRMGTFDEECTRFYGAQILDTIGYMHRRGVIHRDLKPENVLLDNQMHVKITDFGTAKILSMPSPKEGGNDNGIPSMDMPEDERARSFVGTAEYVSPELLTNKSACKASDLWAFGCIIFQLLAGRPPFKAANEYLTFQKIVALEYEFPKGFPPAARDLVERLLVHDPNTRLQIEHIKNHEFFNGITWGRELWKQKPPRLKSYSPPTEPIKLNGPDDDDSFPPNINMKPSAGLPPSSTTSQNRSYPPVITELPPPSQLDIEWSPVLTRTNERILKLGNLTVSTSSAPRSQNKNGNGDGDTPKKLSRFFGGSATKKRQRLVLVTSAGRVIIVPAGGEDKRPKMDIMLLNPDTQYRSITDSKGYTSWAIDTVSSQKPTKAATVCKKAFTDFAFFGSSQREKHHVFEETKPNSDAAASKLATQEWLEVLDRAKELASVYSTPNSYTGDDGFRDLSSGVSSHANTLNHADDSPTGQYPQSSGRNALSKPSPEGDSKSKKRFSRRHSRNGLSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU2</accession>
    <name>D4DHU2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019200.1">
        <property type="nucleotide sequence ID" value="XM_003019154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU2"/>
    <dbReference type="GeneID" id="9577197"/>
    <dbReference type="KEGG" id="tve:TRV_06749"/>
    <dbReference type="HOGENOM" id="CLU_006586_15_2_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="37315" checksum="99C46D6B7A0D92F4" modified="2010-05-18" version="1">MPQSEDCLKLNIWAQDTSQKKKPVLLWIHGGRRSIFIPSLIDINRVNGSCNVLGFSLGSTNNPFYQGQYIGDKEGIIVVSMNYPGAPGSPWKIALLDQRMAIKWIRDNIAAFGSDPCRITLACHPAGGVTVDYYTYNYIEDPIVYAVVPMPGSAISFLPNTPEQSEKYYNLQLPPVFRPTIDEKLVFSNYEERAAKRMFAMIVSLTHALNITTISEKAWHLFNLAGFTCSNAREASYRSAMCVPTQLYIYISEWPNSILFPESGSYHGSDVAQLFGTSEDISNGTANTETEVKSSAYMMHAFMGFAADPRKGLSRFGWPIYRINGRGVQMNSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIF8</accession>
    <name>D4DIF8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018955.1">
        <property type="nucleotide sequence ID" value="XM_003018909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIF8"/>
    <dbReference type="GeneID" id="9582115"/>
    <dbReference type="KEGG" id="tve:TRV_06966"/>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013356758" description="amidophosphoribosyltransferase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="602" mass="66362" checksum="F8C6E59041A25669" modified="2010-05-18" version="1">MCGILALILANPTEAASVDLHEALYLLQHRGQDACGIATCASAGRIFQCKGEYLGLLVPVEYRTKIKTVRQWNVWKSLPRRLGHLRYPTAGSSANAEAQPFYVNSPYGITLAHNGNLINAPELKRYLDYEAHRHINTDSDSELMLNIFANELNETKKARVNVEDIFAALSRMYERCEGGWACTAMLAGFGVLGFRDAYGIRPLIIGSRPSRSGPGMDYMMASESVALDQLGFTNHRNIVPGEAVIIQKGHEPVFRQVHPKLNYTPDIFEYVYFARPDSVIDGISVYRARQRMGEKLAKRIITALGPDAIKDIDVVIPVPETSNTSAAALARYLDKPYSQGFVKNRYVFRTFIMPEQKARQKGVRRKLNAMASEFKDRNVLLVDDSIVRGTTSREIVMMARDAGAKTVLLASCAPEIAHPHIYGIDLASPHELVAHDRDINAITAYIGADAVIYQTLDDLTASCAEICIESGNAEPVKFEVGVFNGVYTTPVSANYFEHLEKLRGEGRKIKRVESARAAVLNGVASHENILIASSKVDLDANGKPLVVDTVRPVTDAPVANSTDSSLQAQAQANSQSQHQKPTEVPPHVKDRMDISIHNLGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIQ9</accession>
    <name>D4DIQ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000410">
        <property type="protein sequence ID" value="EFE38256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018901.1">
        <property type="nucleotide sequence ID" value="XM_003018855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIQ9"/>
    <dbReference type="GeneID" id="9582068"/>
    <dbReference type="KEGG" id="tve:TRV_07069"/>
    <dbReference type="HOGENOM" id="CLU_1606691_0_0_1"/>
    <dbReference type="OrthoDB" id="4174418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="20692" checksum="D9418F791F0A828E" modified="2010-05-18" version="1" fragment="single">SSSNTGSYGSSGNDSYGSKKDNDSYGSSGRSGNNDSYGSNKSSSNTGSYGSSGNDSYGSKKDSDSYGSSGRGNDSYGSKSRDDDSYGSSGRSGNTYGSGSGNDNDSYGSKSRTSGNTYGSNDNDNDTYSSSKKSGNTYGWSNDDSYGSKSRTDNTSSSYSRTDNDDDNENKSATSKVLGKVGEMIGNKLSGSGHGDSSSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU3</accession>
    <name>D4DIU3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase (UroS), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018878.1">
        <property type="nucleotide sequence ID" value="XM_003018832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIU3"/>
    <dbReference type="GeneID" id="9580050"/>
    <dbReference type="KEGG" id="tve:TRV_07104"/>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="307" mass="34329" checksum="50B631F2D54092A4" modified="2010-05-18" version="1">MSLLPVTKEIPIYFLKTKSTPHDGYEEYFSPSKGFKPCFIPVLEHKFNHNNLQKVKDLILSGAVAKQYGGIIFTSQRAVEGFSRMVQDEVGREEAGTGEKLSGLILAHYNGLRRNTSDGNGPSRGIREKLPLLFLVGEQHRDIIPKTLMSPSLDEEERIGVATMVVYETGVMESFGQDFVAALEMEERANKANISAGNTSPHKQLIWVVVFSPSGCKVMLQQLGLLEEDQPEEHTSSVQAPGKKRTPSRWSRFDYRIATIGPTTRDHLVSNFGVQPDVCAEKPSPGGLWEGIEPIIEEWKMSREQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIV4</accession>
    <name>D4DIV4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018847.1">
        <property type="nucleotide sequence ID" value="XM_003018801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIV4"/>
    <dbReference type="GeneID" id="9581491"/>
    <dbReference type="KEGG" id="tve:TRV_07115"/>
    <dbReference type="HOGENOM" id="CLU_006822_0_0_1"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139843" checksum="ED56C7F97859568E" modified="2010-05-18" version="1">MSVLRHGSAFLQRRLTKLYTDTKSSCESATTAARPNDDPELVSLNRHFRTQKDRLLAWGLDWSDASAAQPNDIDEALTEAGFSDVVASVMSSIQKLLNEAERLQHPNPATISPDGIAGKAADGSYTTGTTGGVKTTWTEAEISRSKVLLEELTSHIDTLYDLSASRRDMSMGISSGTPQSEKYSHHRGLSKQSKETKESLRPKLPTSKSAPSKTTHHLEVSPTLATNDMSAVNPFVSMHIDPSMTIENAAFQQLPLHTEENGEFFLDRNALSLSKEHVSHATTPPPYEAIAASTSSRAMGFIKREAIPSCMARGCTSMSIPVMVEFLPILMEAQQYLARPLKQRLKSIGQTLDRLIENSRVSHLGLLKFLGYYIDMTYSRYGFVYHTPIDTFPFLKQPSDTIQPKPLVSLLHNGDDKQEGPVPNLEDRLALAYNLLLSVLHLRSQNLVHGSITAIILLYFQEFTYPTMGPLATRAWTIGGLTLPHLASLTVKIRMHRQNPYRRLKYNNSMFKSRIENVYVKKLAAKCGGAYMQVVQLCLDAPNFHLSTEPMADLGLRIPQTYHYPWHDPGNSNDWNTFSKNFVYTIGKILWRCCGIDVFSPPPASDLEDSLPPPLGLEPGLSSFQQIPLNERDLHIVEPTVSIDIPYDISANPDIKGISEMCEGNEKKGRKRSMKKWSNVEIPEEHLQTWNKTLMPKISKLLQKILKDSPESCSATLLVAGETADTAKTTICVTCTNVRKVRAALKKYFEYDRENWNLIVIRGDIKRSKVPRKKRRKPKSNKGIISPEISNPDFNSHYQTKPICGASIGAFRYGEHLPPVSYGGAILVDGIPYGMTVHHMLDTPCDDDDDCEDDYDYDGGDCPPRSSANYLHGSDDANQGPSFSWGEPNIHEDGYPLEFSDDEDGDDDQSIAHSLDESFDDHWLSDGYSSDEGDDYSGFDDDDTASIGDTVGVDPGEKPRIMVTQPALDDVHEDFFPSPEDRDDEHLASHSLGFVHASSGVRRWTKDGIKHEVDWALIKVDLNRMEVKNLVPVSSPQPNTSKPNNRRQPQGNAGSFQTLTKIAKFDDLGGLNVQCCGRTSGFQSGKISKALTLVKMYGRQSFSTSFSVDGNFGVPGDSGAWVFNDKGQVCGHVLAWSEKSRSAYIAPMEILLNDIARTLCAYSVKLPDGDEEICYRDSSPPPPLQGIPPPMFSVHATKPVSPNPVIAEHLPVDLQKLTLDLEETPRNNTRVGGVKKKDVSGTYRASTPLMQHARMERQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ02</accession>
    <name>D4DJ02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018807.1">
        <property type="nucleotide sequence ID" value="XM_003018761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ02"/>
    <dbReference type="GeneID" id="9581205"/>
    <dbReference type="KEGG" id="tve:TRV_07167"/>
    <dbReference type="HOGENOM" id="CLU_075862_0_1_1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29092" checksum="3E3EE7BB49EB46C4" modified="2010-05-18" version="1">MLSVQKYIELSPFPLTEGDIESLGQNDEEYIPHTWQEIKDVIAEGDMSVLNRAPSDLRNYILWVRETRNNNDSVIEFLLRERLLWKKKAQAEQAEDSNNTQSPTGLAFEYQDETPFAHPADYKILRNDWPYGLEHNIVHLVVWLKTRIPVEEDGQGGPTAESRKLIEDFVDRTFTQRIVERHREVNGNCPNNIKEEKVMWFKNKKKWQTVASIEHIHVILRDVDEDLVVGWTGQTSMDITARSYVWNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ58</accession>
    <name>D4DJ58_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000423">
        <property type="protein sequence ID" value="EFE38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018762.1">
        <property type="nucleotide sequence ID" value="XM_003018716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ58"/>
    <dbReference type="GeneID" id="9581155"/>
    <dbReference type="KEGG" id="tve:TRV_07224"/>
    <dbReference type="HOGENOM" id="CLU_008571_0_0_1"/>
    <dbReference type="OrthoDB" id="10016792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="104197" checksum="3E7E8D26D9077FA2" modified="2010-05-18" version="1">MKPSASIALPNSDPLPDSDTVKYPIVNPQVFLSVSDDAPSIGGTIKTPFAFYVEKFSLTHDLKSENEEKEPFDRYCIYTGELYGPELASKGCSIIISGKGGVESNPDAYQGGTLQIFAEHVEAAAVEKLHLDAGGGPGANRQPVTGTDVGPRGGNGGQGGRVDIVFGCIFEQAIEQGAELVKGLMDPKKKWPTDFENKIKLFVGFITLKEIMAAMTIPPSLNKVETMMATPKESIQPTLIQFLIDLAAQRDSLTNAFEQHTNVEGGPYGTGGMGDKQRGPNGDTGKPGSHSIYILSDPAKLLESAVCFVHPTQCRMLLDMANLLWFCGSLNEKARAANIYSRLTRRLAFLGDEKDGKISKTPLAEAYRKAEPSLFILGGAPGDEPISFTLLRAVKDEAHGNLLSLLSGKTIFGDDREKVPRGSFGFYQTAIAPLLTNLKEVETTYRRFLGGEMDAEEKKQAVRDRLARCDFRKRLVQDEIKEKKNDLDTNLQRLHLSTESIGPAKKSLMNAYKAVEKQVRTGVTVSWEDLMSALSQVIFVHGSAPMVALQGADLIHNALEKLKSDSSVSIDRSLLLHDAKDMKESIEGLAEGYTLLKDGGVDFDDPAATKLQVLAEKADAFWSQFENILGKPVLENLRKRFHDYIAIVKERNAAVIGYTEAVLLLIKYQTELDALAAERADISREEYDQLGADHPTMTAFMKKLYTDAIHTTQEWLYKAQRSYQFVSLDRANVVGEQMEGFKFSTFNSTTLISANSTLVTRYNAFIEKAGTEPQTFNGLRYDIDEMYVDMIQDSGTDGITHTIEIPVFDIHKPNPFGSMVDIRLTKVRFYLDGAKTKSHFMDLTLKHQGKETILNKQDERFDFVHDPLITKFRYNIDNPMVMGPGTTDGDVGSVGEDRYAKVGPFTQWTFQVTTDNNPGLSLGKVCKAYFMFWFTYYETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJK0</accession>
    <name>D4DJK0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_07368</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018608.1">
        <property type="nucleotide sequence ID" value="XM_003018562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJK0"/>
    <dbReference type="GeneID" id="9584535"/>
    <dbReference type="KEGG" id="tve:TRV_07368"/>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="285"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="542"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="798" mass="88640" checksum="AC09FB876D2E6CDE" modified="2010-05-18" version="1">MGHVYIWSYETQSIIKTFELTDVPVRAGRFIARKNWIVCGSDDFQLRVYNYNTSEKIISFEAHPDYIRSIAVHPTHPFVLTASDDMTIKLWDWDKSWKCVQVFEGHSHYVMGLAINPKHTNTFASACLDRTVKIWSLGSPNPNYTLEAHETKGVNHVEYYPQADKPYLLTTSDDKTVKIWDYTTKALIATLEGHTSNVSFACYHPELPIIISGSEDGTIKLWHANTYRLEQSLSYGLERAWCVSYQRGKQGIAMGFDDGAVVVKMGREEPAVSMDGSGKIVWARHNEVVSTVIKGGDATLKDGAPLSLPTKDLGSCEIYPQTLAHSPNGRFVSVCGDGEYIIYTALAWRNKAFGQALDFAWGSKDNSNDYAIRESSTSVKVFRNFKEKSGGLDVGFHAEGLSSGVLLGVKGQGGIGMFDWETGELVTLACEDTFYVLRFSREDYIAGLNAGQADEDGVEAAFEVVTDVNETVRTGEWVGDCFIYTNSTNRLNYLVGDQTYTISHFDQPMYLLGYLPRDGRIYLTDKELTTVSFALSLSVVEYQTLVLRGDMDSATELLEDIPKDQMNKIARFLEGQGYRDFALDVATDQEHRFDLALGLGKLDIALEIAKVTDVEHRWKTVGDAALAAWNLSLAEECYSNAKDLGSLLLLHSSSRNSAGLQKLAEQAKQAGSHNIAFTALWQLSDVDACIDLLVQTNRFAESVFFAQTYKPSRTPELTVQWKQSLEKNGKTKVARIIGVPPGVENADDDLFPEWDNYLKLEAEGGIKTANLIDIDANGDEEEAATEETAEEPVNGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJL6</accession>
    <name>D4DJL6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018624.1">
        <property type="nucleotide sequence ID" value="XM_003018578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJL6"/>
    <dbReference type="GeneID" id="9580775"/>
    <dbReference type="KEGG" id="tve:TRV_07384"/>
    <dbReference type="HOGENOM" id="CLU_1180944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="26884" checksum="27B5BEC61D74E1F3" modified="2010-05-18" version="1">MLSPTNKLDRPSQGAKEKKSKERAYLGRLARGDRGDRGERGEEGREGSGRRPMKRPGREEREKTGRSKYRAKTIKDDGEEEAKKQRQRRPVTGWAAVEMDAGDGAARRRYAFNVGFPWGGRSAPDKDFFLLLLLLLRLAAVPKLKVRERDRKGKSNEEVNKRKRKRKKNKSAKEPERDPLFWGCRRVDKGKKQREEADEDEDADLALTCMDQETDTETEAEAERRGKAGQGFTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJQ2</accession>
    <name>D4DJQ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018575.1">
        <property type="nucleotide sequence ID" value="XM_003018529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJQ2"/>
    <dbReference type="GeneID" id="9584504"/>
    <dbReference type="KEGG" id="tve:TRV_07420"/>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OrthoDB" id="4540498at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="42463" checksum="8C3E3873CEC0F843" modified="2010-05-18" version="1">MANSKIPDYFCVTGAGSKRKHDTPDQDESISSKRSSRPYDAVSSLGDLKKGPNRVAFDARIVNIYNQPNIYFDDNAESISKSSKKKKKPSKSDSDPIASQQARGCLKLILRDDTGYILVKLWYADTTYDLRLGKLVSIWVTHISPFKPQLKGHVKADLSSTLSKPATPPSTPPENFPLSLMASIFPEKDQGCGIKIHERGDIGIIGRIPMGYRYPFQVDSLVDAPKKHSMGKPTKVLVYVYAVGPVRETTNSSNQTVPTVDVGVTDGHSRASLGLYGEAMKSGVKWIPNSTVLLISNASWKPGSRLYLTSFTLVDVDPESVEAEELKRLAARRAEQVNPPFPTDLFNVEEFESSVQKIKFTLADIEELYAYLSSFYDGCMLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJV8</accession>
    <name>D4DJV8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018530.1">
        <property type="nucleotide sequence ID" value="XM_003018484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJV8"/>
    <dbReference type="GeneID" id="9584459"/>
    <dbReference type="KEGG" id="tve:TRV_07476"/>
    <dbReference type="HOGENOM" id="CLU_1490027_0_0_1"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="182" mass="19919" checksum="D62DB14DB335AF01" modified="2010-05-18" version="1">MTRNSHVSNRSKETRKATATPKTGVKSKNTNNTSEFVPNTRPTRGQKEVRVCRPRPKLLLEYSGAAGSNSKVPVKVSIQHAINQAVRESRGAESSSDEEELDPPATPEGLDPLYSFDANTSPAQGGHVLSAAVVQAVDKFETKQTEKLAREYEFVGLVDPEDFDEGYGGHEDGFELIEPVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK36</accession>
    <name>D4DK36_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018429.1">
        <property type="nucleotide sequence ID" value="XM_003018383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK36"/>
    <dbReference type="GeneID" id="9584358"/>
    <dbReference type="KEGG" id="tve:TRV_07557"/>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000004">
        <property type="entry name" value="Alpha,alpha-trehalose glucohydrolase TreA/Ath1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055594" description="alpha,alpha-trehalase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="14">
        <location>
            <begin position="71"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="12">
        <location>
            <begin position="431"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="13">
        <location>
            <begin position="774"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114736" checksum="83FC3F438403EB07" modified="2010-05-18" version="1">MKQPNINLAACILWLLSIITAVAAETDAERNTGVFARNSAARNRSPGNEPPGYATRFKGVTWDVANWRLTTTELDQGHYQSRGSVANGYLGINVAAVGPFFELDIPVSGDVINGWPVFSRRQTFATISDFYSFQRSINATNFPWLDKYGGDLISGVPHWSGLILDLGDGNFLDATVKNSTISNFSSTLDMKGGILTWQYTWSPEKHNGTYDIFYQLVAHKLHVNQALVRLEITPSRDGNVSVVNVIDGYSAVRTDFKGSGQDGSAIYTSVNPEGISNVTAFIYAELSGTEGVDLSSSSLVDDKPYIHMNGSTIAQSVNVKLRAGQTTKIDKFVGAASTDGFKNPRQAAKEASARALRTGYEESLKSHIAEWATVFPSDSTEDYTIPGKKWLPLDHHIIEASIVSVVNPYYLLQSTVSNNALAAVRNAPLNRGSIAVGGLTSDSYGGLVFWDADIWMQPGLVVAFPEASQIFSNYRVDKYGQALRNAQTQHLSSKNDTYFSPDAAVYPWTSGRFANCTATGPCFDYQYHLNGDIGMQIVNNWVTTGDTEHFKSKLFPVYNSIATFFSQLVEKNGTKWTVTNMTDPDEYANLVDGGGYTMPLIATTLKYANQFREMFGLGANQTWNEIAQNVQVSRDQASQITLEYTTMNGSTQVKQADIVLNTFPLHYTEDYTHDNALRDLDYYAAKQSPNGPAMTYAIFSIVANEVSPSGCSAYTYGQYSFSPYVRAPFFQFSEQLVDDWSINGGTHPAYPFLTGNGGANQVAVFGYLGLRLIPDGILHLNPNLPPQIPHLRYRTFYWHGWPLEASANYTQTTIQRATNRRPLTSADPKYASAPITVHVGPANNITVYSLPPSGQLVIPNRQIGSISTLAGNLVQCQPVFSPNEFSPGQFPISAVDGAASTKWQPRRASSTSSLTVTLPDHASSATISGFAFDWAQAPPVSAKVVLHDEPLHPVTDPENGGASGSSPTTPASSVTVWESAKVPLSDPYDPIKIDLNMIMSYKGNTTNVTLPSTVPATKFATLLIRGNQALGPVEVRAGNGTGATVAEWSIVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKI0</accession>
    <name>D4DKI0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018252.1">
        <property type="nucleotide sequence ID" value="XM_003018206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKI0"/>
    <dbReference type="GeneID" id="9579984"/>
    <dbReference type="KEGG" id="tve:TRV_07702"/>
    <dbReference type="HOGENOM" id="CLU_1075897_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="259" mass="27578" checksum="03F486CF0684E9C1" modified="2010-05-18" version="1" fragment="single">PSQPSSLWLSSGSPLALLWLSSGALSPSSFPGWFTKADGAGGFCCPPLPRLIFCFSSSSCFLLLLRSLYLTFAITFGSPACTSLPLRLSLARVARVALVVGLPSRVAVVLQLDAVQPFNFILCQQKYPDNILTSALIVSLSSASYRSSRRTGGSPVAQVSIRMLFIQGPCLLHGFGLTDMARSVAYRVPYSTFIMAAIISLRDVHAASHQLTKRKNWAAREPGVVLVSASSSLSQSACCPHTSTAGCNAVKLLLAQPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKU3</accession>
    <name>D4DKU3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_07817</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000483">
        <property type="protein sequence ID" value="EFE37536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018181.1">
        <property type="nucleotide sequence ID" value="XM_003018135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579551"/>
    <dbReference type="KEGG" id="tve:TRV_07817"/>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="456"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="689"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="884"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE37536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1373" mass="148540" checksum="695E431F26429259" modified="2010-05-18" version="1" fragment="single">DNSFDSSSNMASSDSLFLTLPGSVAFSEFRCRGIAANTNAKAIRAQWVHYLHLAEPLQDNQPTNLEQLLRYGDIADSPGSFGPQDGKTLTYYVSPRVGTISPWSSQATGIAHVCGFQKCLKRIERGLRISCLVDEGVDSLDAASLDVLHDRMTQVISTEEPNLQAMFAEKAPAPLEVVSLKDGEKSPREILQDANKRLGLALDSSEIDYLVDAYAAGGPISRSPTDVELFMFAQVNSEHCRHKQFNASWIIDGEEKPNTLFGMIRNTHKQHPDFTVSAYSDNAAVLEGEEAGHWAPDATGEWVQTKEKVHFLAKVETHNHPTAVSPFPGAATGSGGEIRDEGSVGQGSRPKAGLCGFCVSDLLIPGHRQPWELDVGKPNHIASSLDIMLEAPIGSASFNNEFGRPCTGGYFRTLLTKVDTGNGESEIRGYHKPIMIAGGVGTVRPQHALKNPHAVKPGSYLIVLGGPAMLIGLGGGAASSIASGEGSADLDFASVQRGNAEVQRRAQEVINACVAMGADNPIKFIHDVGAGGLSNALPELIHDAGLGASFELREIDNADKGMSPMQIWCCEAQERYVMAVSEGGMNSFVTIANRERCGYSVVGRGLGQPDESRRLVLLDKDSKEYPKPIDLPLSVLFGKPPKLTRTVSSRKLNLPAFDSSLKTYIPSVPEQGLMAEAVDRVLHLPAVGSKSFLITIGDRTVGALTARDQMVGPWQTPVSDVSVTATSLLLGMKTGEAMAMGEKPNLALISPAASARMAVAESLMNIAAADLPERLSRVRLSANWMSATNHPGEGAAIYEAVEAIGMDLCPKLGISIPVGKDSMSMKMKWSDQETGQSKEVTAPLSLVISAFAPVQDIKNTWTPTLRSFEEVGETVLMFVDLSCGSKRMGGSALAQVFGQVGNECPDIRDVQLFKDFFDATQSLQEAGIVLAYHDRSDGGLFTTIAEMMFAGRCGAQIMLDEICASPNVKDAIETLFNEELGAVFQVRKAHEGEFRSCFATCGPPPGLIYRIGRVAEKQKQNLAIYHGATLIYRESRSHLQRAWSETSYRMQRLRDNPDAADQEFENILDDNNAGLSYNLTFNPKETGLPLMTSLTSRFSPFATRPKVAILREQGVNSQAEMAFAFNMAGFSAVDVHMSDILTGKVSLSSFVGLAACGGFSYGDVLGAGRGWAKSVLLHKQTREEFKLFFERPDTFALGVCNGCQFFGRLKELIPGAGIWPNFERNASEQYEGRVCMVRISEPTDIPPTVFFHDMNGSSLPIAVAHGEGRASFEDTPGMDGKELVKRGLAPARYVDNTSLEPTMRYPFNPNGSPEAIAGVRSPDGRVLAIMPHPERTIMAGIGSWFPGDKAMSEEWGNIGPWGRVFFSARRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLE4</accession>
    <name>D4DLE4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017967.1">
        <property type="nucleotide sequence ID" value="XM_003017921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLE4"/>
    <dbReference type="GeneID" id="9579845"/>
    <dbReference type="KEGG" id="tve:TRV_08018"/>
    <dbReference type="HOGENOM" id="CLU_096567_2_0_1"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="184" mass="20820" checksum="E6D9F4297F57FEDA" modified="2010-05-18" version="1">MFVAGLLLKGIKSRYSTGSIIGTLFECCIRFLQFVFGIAVIGLYAQDVDRARKHGDSQDSRWIFATVVGTLSAISGLVYILIPCAVRRPLSQATFIHLPCFVYDSVLVILWLTQFGIFAKLYITVDDDKDKSLKRMKHSAYVDLVNLCFWAITCAWCGIRWWRGNKAGGVQKEEKAFDEHIEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLH8</accession>
    <name>D4DLH8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_08052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017932.1">
        <property type="nucleotide sequence ID" value="XM_003017886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLH8"/>
    <dbReference type="GeneID" id="9579818"/>
    <dbReference type="KEGG" id="tve:TRV_08052"/>
    <dbReference type="HOGENOM" id="CLU_058843_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="336" mass="36157" checksum="6130557BD64D0FE2" modified="2010-05-18" version="1" fragment="single">NPQLNSDCSNIQSKTSYCAFLPSHVSKQTRGQMDPPPKTKPLPPGLFNDWGNNHAQKRNDPPPKTKPLPPGLFNDWGNNGAQKRDGLSPTGGLGDFHGPKEAPPPGWGHKGVVEGNHGKTMSTRSPIMGTGLPEQQSEPAFMPPHIPNLPNGMENKMVVHPTTLTKKLRPTGSYLKRDANAPAPTPGSVGAAIVGCKQYHTVKAKDTCFNVAQQYPGLLFSEFLRLNPPLSNLDTVCPNLQANTRVCVKGDTKTNLVPTPSAVVGVHARDVQGWPSPTKPGTNPGCKSFELVKKGDSCEGVARKHHISVAQLKEWNPAVGPTCEKLEIGYYACVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLI6</accession>
    <name>D4DLI6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000510">
        <property type="protein sequence ID" value="EFE37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017928.1">
        <property type="nucleotide sequence ID" value="XM_003017882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLI6"/>
    <dbReference type="GeneID" id="9579810"/>
    <dbReference type="KEGG" id="tve:TRV_08060"/>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="398"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="509" mass="56260" checksum="BFA484D9482B3EE2" modified="2010-05-18" version="1" fragment="single">MANINPLNVYSGPDSMKKYFDPDCQPPLPLVEIPQELNPFYDDGVRIYAKMMSMHPANNVKAIPALNLLEAEVVPGKTKTVIEYSSGSTIISMAMIANVFHGINDVRAFLSNKTSDAKIKLMQFFGLNITLFGGPSQPEPLDDRGGIFAAQTMALESDQVINPNQYDNDGNWGGHVRYTGPQIFKQLPEINVLCSGMGTSGTMTGLGTYFKKVKPSVLRVGVCTAPGDRVPGPRSYALMSPIPFPWQSAVDVIEEVGSPESFSLSLKLCRHGLVCGPSTGFNLQGLCQQLQKRKDAGTLRSLAGPDGKIHCVFLCCDLPYQYIQEYFDKLKPEDFHPIKNENLRKVDLYRYDEAWESHFAKILAEFYERFPASGPVFGIGKARGFDGLKLKPDHSRCVIDLRKPADFKQWHLPQGINVPLNTLEKSTTSPFADSAVLEAQWLEIEGWFSQSGEKSALLKGLKENNTRVLLVCYSGNTSRVACSIFRAKGIEAWCIRGGYKALADPELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ24</accession>
    <name>D4CZ24_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025734.1">
        <property type="nucleotide sequence ID" value="XM_003025688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ24"/>
    <dbReference type="GeneID" id="9581992"/>
    <dbReference type="KEGG" id="tve:TRV_00061"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="49065" checksum="0E5096D3E35F7CFD" modified="2010-05-18" version="1">MKLSSIFQKPPPRYVVASILCSLGGFLFGVDTAIIGPVTVMDSFTGAFGHPSPTLHGLIVSSILIPAAISSFLAGRVADVLGRPPAIAIGSAIFGLGAAIEAAAVHLGMFVAGRVVAGPQLLITSGLVAGFFTCYRSVKIVTTLSWRLPFILLASYSATFAVVAYVFLPPSPRWLAATYGQNTAAIDAAWDRLSVLHADREVMPSNQEEEPKIRSKTLDVFSAEARPGFLLAIFLMGMQQLSGIDGVLYYAPLLFQQAGLTSAGDTFLASGVSAIVICAVTIPATIWADSWSRRRNTIYGGLGMATTMFIIGGLYAGDAVHSYGAGRWVVVISIYLYTVIFSISWAVAVKIYAAEIQPQRTRASATSLAHGSNWITNFLVALVTPTLLANTSYGAYFLFGSCTFATAIVCWFFMPETRGRTLAEIQQALHTSRSSGVDTPAKTLWRRLRRAPAIAVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ98</accession>
    <name>D4CZ98_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000006">
        <property type="protein sequence ID" value="EFE45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025689.1">
        <property type="nucleotide sequence ID" value="XM_003025643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ98"/>
    <dbReference type="GeneID" id="9581931"/>
    <dbReference type="KEGG" id="tve:TRV_00139"/>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="331" mass="36707" checksum="438893F93E8A5445" modified="2010-05-18" version="1">MPVDKAFILSQRPFGFLAFFSRWLRAFTARLSGRQNYRPLAEPESTQEHPISVVCISDTHNWQPELPDGDILLHAGDLTVNGTFEELQAQLTWLSAQPHTYKILVAGEHDVLLDPPFAQRNPDRYPSVPGRTVCDLNFGSVIYLRDSSVTLQFPEHGNGREVAIHGSPSISSSSRVGAFHVPRGTDVWTRAVPEGTDVLLTHEPPSKHLDGDLQSGCAFLGQEIERVKPRLVVFGHVHDGYGVKTTNFDEKVVPVEEEATNRQRKGWGPLLRATWEQAGHLFEYIFPAVASSPTPEVEKPKPAVTTFVNACLIGDLLDGNDNINEPIVTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZA5</accession>
    <name>D4CZA5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000007">
        <property type="protein sequence ID" value="EFE45070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025681.1">
        <property type="nucleotide sequence ID" value="XM_003025635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZA5"/>
    <dbReference type="GeneID" id="9581920"/>
    <dbReference type="KEGG" id="tve:TRV_00146"/>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="35"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="358" mass="40102" checksum="A981267D9CF6CE31" modified="2010-05-18" version="1">MAPAIASATVTPSTTAHSTWKAPLRRTGAIDQYEREDVTPIIGTEFPTAKLADWIKAPNADDLLRDLAILISERGVVFFRQQDGLTNTKQKELMQRLGELTGKPPTSRLSIHPIFEQGANDPEINTISAAQDNKLRSIDYSVSIPKKQSSAHWHSDVAFEPIPAEYTTLRLTQVPKTGGDTLWASGYELYDRISKPYQRFLETLTATCAQPGYNKVAASGKFKLFDGQRGAPENIGSNFSSVHPVVRTNPVTGWKSIYSAGFHVQKINDVTEAESKALLDWFLRLINENNDLQVRFKWKNANDMAIWDNRCVFHTATFDLEGKEDRYGVRAVGVGEKPFFDERSMSRREALKEPVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZN7</accession>
    <name>D4CZN7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025517.1">
        <property type="nucleotide sequence ID" value="XM_003025471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZN7"/>
    <dbReference type="GeneID" id="9581754"/>
    <dbReference type="KEGG" id="tve:TRV_00279"/>
    <dbReference type="HOGENOM" id="CLU_040328_1_0_1"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="375" mass="40980" checksum="3C5F2D638A94A03E" modified="2010-05-18" version="1">MAGDKKLLVILESTLGLSTQFISSLSLSAASTSSAPRSPEGNDNNKNLPLPLLSAAAQTLKSNTGKISLFAINTPFTPSAITSVLTQINDSALPSLVTAAFLLHPEHCTKTFHAEINTLVKSALREYITLINDIKKIAVENGKSLTDEDKAAVTTSAGRVWKVCDQLVAASTDGVVGMVIQKANEFLELVRDGIKELEEWDPEESDDDDWGLVDDLADETKEEKDEDDDEDREEMVAMLSGEKKDLLRLLTPIAKLYTAVTTQRLKPLRHQPILPKYASNLDKLMDNLKQIPDLVDEAAGSLYEHDIQAVASYTSKLKSCAISTVEIVKKPWYPETGVNTKTDGQVEAEDKFSKWATVWLNVLNELGKPGVANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZR5</accession>
    <name>D4CZR5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025545.1">
        <property type="nucleotide sequence ID" value="XM_003025499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZR5"/>
    <dbReference type="GeneID" id="9581782"/>
    <dbReference type="KEGG" id="tve:TRV_00307"/>
    <dbReference type="HOGENOM" id="CLU_1054452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="30415" checksum="01BE67DE78603DCF" modified="2010-05-18" version="1">MTKKRKKKRKKPREEDEDEASQQGTATRRRAAGLVREDAGREEAEEEEEEKKKIKKMDYSTIKREEEEEEEEKRIREALAGVFSLFVFVFFFTAGFFSSSLLLLPLTLPLTALLLPTIDCSLFLSLSLSASSSLLLLFFLFFFFNFTFSYFFTFFYFFFLAFFLFFAVDFSITRRRWTLGLQDIKQTDRQTDEDEDEERPRIPLCGLFSDSLDSLASLEQTTSGSFASASAYKAPSSSAATTTTTIYTLDISLYITTISLYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D054</accession>
    <name>D4D054_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025387.1">
        <property type="nucleotide sequence ID" value="XM_003025341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D054"/>
    <dbReference type="GeneID" id="9581622"/>
    <dbReference type="KEGG" id="tve:TRV_00448"/>
    <dbReference type="HOGENOM" id="CLU_017661_1_1_1"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="721"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="87133" checksum="B07F6AB64974C6BB" modified="2010-05-18" version="1">MYIASHEVFCLLFSTYLGPTKRSSQQIRLWVEKKKKRRRRRRRKEEEDEVKEEEEEKKKKKESKEEKEEEEEESRRPQDQIPKTDKERESKEREIYHLLLFSSPLLLLNKSLACLLLACFLLPLTNRRLSPLPLLLTPLLTLFFSRSLQVFSLSPSLTSSSSLTSLSSLFTAGSPSTSTMTVDFRPPPSALFAFPPDSRPAVLPPAQQSSLSWHHPFNIPPAVYSALLRPAVPIAIAATYALTVSYINRLNRRRDHRPWAVSKTRPFKLFVVLHNVFLAVYSLWTFLGMIRAFRLSWPEPSMRSSPAAIVDCLCKINGPRGLGNAAVYDTNTNRWTMTNPDSGYHLTPEGLPDATDVGRLWNSGLAYFGFLFYLSKFYEVLDTAIILAKGKRSSTLQTYHHAGAMMCMWAGIRYMASPIWIFALFNSLIHAMMYTYYTLTALRVKVPTRIKRSLTTMQIAQFVIGTLLAAAHLFISYTVPVQESHPVALQPLTETIPSQDTTGLLPWLKKLAFRAAGADGVAANVLSANRTLFGADGSHAAHALVNHRELRKQTLQTTVPCINTSGQAFAIWLNLVYLLPLTFLFVRFFIRSYLRRTNEHQHHAAEKAIKDVTREISKAVREMHGNTSDGPSSGSSTPRPERAYEANVLDLLNRKQRIAEKEITTKPIPLTPTSPTQEESQEENQENQENQSTATSTAIDVATVTQEQKYEANLKDVMTAEEKAIDSHPEESTALCVDYEAATPHSPSPSHSPSPSSPMSHAQRRKKKAAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D070</accession>
    <name>D4D070_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025403.1">
        <property type="nucleotide sequence ID" value="XM_003025357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D070"/>
    <dbReference type="GeneID" id="9581639"/>
    <dbReference type="KEGG" id="tve:TRV_00464"/>
    <dbReference type="HOGENOM" id="CLU_1620263_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="164" mass="19034" checksum="0F45BAA0D4ABB6C5" modified="2010-05-18" version="1">MNRQRTNPRSKKKKKKKKESSKVKTSLTMVSLEKDDEGSLFFFSSFSLCLRCSVSLKRLSTVKISSSSPFRVVEVAKLRSCWSWSFFFFFSSSFDVEGGNPFWETRQKKAPQLDDDDEDNNNDKDNDEDDEDDDDNNNEDGEEAFILLSGAEGMPCSAWWYIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0E9</accession>
    <name>D4D0E9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short chain dehydrogenase/reductase family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000030">
        <property type="protein sequence ID" value="EFE44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025284.1">
        <property type="nucleotide sequence ID" value="XM_003025238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0E9"/>
    <dbReference type="GeneID" id="9582893"/>
    <dbReference type="KEGG" id="tve:TRV_00544"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32251" checksum="F1F87B790E546F56" modified="2010-05-18" version="1">MEVASAPFEDNRQPALGRDQKALPKWTLHPSSMLKFVLPLPSGRISSCDCLDSNKNVQGKVVLVTGDAKGIGRMISEGYVVNGATVYITARDIKTCEAVCQELNALGKGKAYAIQADLYKEEDCKKLAEEFGKRESKLNILVNNAGSNWGAPYDEYPSSAWTRVLTLNLHRVFNVTQLFTPFLEKGAGELDPARIINIGSVDGLRVPALETFAYSASKAGLHHLSRVLANHLGRRNITKMMKATLDKFQEVIEAGIPLGRIGTPQDVAGACLFLSSRAGAYINGATITVDGGSVIGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0T3</accession>
    <name>D4D0T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_00679</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025153.1">
        <property type="nucleotide sequence ID" value="XM_003025107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0T3"/>
    <dbReference type="GeneID" id="9580646"/>
    <dbReference type="KEGG" id="tve:TRV_00679"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_5_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="597" mass="66650" checksum="974E49BB1124637F" modified="2010-05-18" version="1">MADESGMAAKYQMLEELGSGSFGTVYKAIDRATGEIVAIKHIDLESSDDDIQEIQQEITVLSTCASPYVTQYKTSFLRGYKLWIVMEYLGGGSCLDLLKPGVFNEAHIAIICRELLLGLDYLHQEGKIHRDIKAANVLLSHTGKVKLADFGVAAQLTNIKSQRNTFVGTPFWMAPEVIQQAGYDFKADIWSLGITTMEMINGEPPHASTHPMKVLFLIPKASAPRLEGAAYSWQLKDFIAQCLEKDPDKRPTAKELLKHKFIRSAGKTEALQELIQRRQEWEATKGLAANIKYYAEPMDTITNKNTDDDAWVFDTIKPGTPAPSKSHHIKNQPSVSNPEDAYEPSESMYNLTLESEFSGPKPVANSTVRRTRGTVARTPSKRSTRRRSSSVKQPLGLDMTFGNSPSTVRQFRRVSDRQNSLDGNSGYVPGMNENSMPKTLFTEPNSKEAILGRRMYNSGIGLTCQEVLANTSDQEKREAISRLAEAFSDLEMIDPEGLYHIVKSSFEKLQADPKLSAILPKPAPETPQKPKLVLAQNNPHLKSHRRRQSAQVQSEQNWNSGSTMAGQHPIGMEHTKQLADVLYTRWTDGLRNRWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Q8</accession>
    <name>D4D1Q8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_01001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024836.1">
        <property type="nucleotide sequence ID" value="XM_003024790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Q8"/>
    <dbReference type="GeneID" id="9580314"/>
    <dbReference type="KEGG" id="tve:TRV_01001"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="469" mass="51093" checksum="B4D31A2CD9C2CB0D" modified="2010-05-18" version="1">MSESGPPPPGATAAATAGKDGSAVKKAFPHVDLAGHDLPPSPAPSSPRAGRRYALATELVYTEGNDQFNASSVPIYQVNITTMISSYLSHDGYSLFCCFTNPLYHTQSATFKQTSGGGGGEYDYTRSGNPTRTHLERHLAKIMSAQRALVVSSGMAALDVITRLLKPGDEVVTGDDLYGGTNRLLKYLSTHGGIIVHHVDTTNPENVEQVLNSRTAMVLLETPTNPLIKIVDIRRISTVTHAKNPGALVAVDNTMLSPLLLNPLDLGADIVYESGTKYLSGHHDLMAGVIAVNDLTLGDKLYFPINASGCGLSPFDSWLLLRGVKTLKVRMEQQQNNAQRIAEFLESHGFKVRYPGLKSHPQYDLHWTMARGAGAVLSFETGDVMISERIVESAKLWAISVSFGCVNSLISMPCRMSHASIDAKTRKERAMPEDLIRLCVGIEDADDLIDDLRRAVSHYLPFFHKNLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D231</accession>
    <name>D4D231_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024670.1">
        <property type="nucleotide sequence ID" value="XM_003024624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D231"/>
    <dbReference type="GeneID" id="9582878"/>
    <dbReference type="KEGG" id="tve:TRV_01133"/>
    <dbReference type="HOGENOM" id="CLU_053567_1_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="3">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="29978" checksum="9F94E4672065A267" modified="2010-05-18" version="1">MASQSPRKDTGHAQRQLRPPQLPPPTTLPLRYCSHNEDSTPIDEEECLLSLLSPNPDAKKNKEHFILATADPAPETTTQPDQKRKLPHWMQAQEGLQQQQQRGQRYHLRRDARQIPGVPIIYVKRSVMILEPMSEPSSNIREGFEEGKLRSGFIEPATSTGKRKRGAEEEEEEDGDGGEWVEVKKKKKVKGVNPLSMKKPKQRTQTVQKPRKADENTAKGGSDIDKGTDGASEQTKSKRKRRHKKKAEPIDGAEKDNDTPIADTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D255</accession>
    <name>D4D255_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024694.1">
        <property type="nucleotide sequence ID" value="XM_003024648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D255"/>
    <dbReference type="ESTHER" id="trivh-d4d255">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="GeneID" id="9582869"/>
    <dbReference type="KEGG" id="tve:TRV_01157"/>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="31448" checksum="332FD3D6471120CA" modified="2010-05-18" version="1">MAVTTKATISSFGGKLLKLSHNATSTKCEMAFNLYLPPQSVSDSGYKAPVLFFLSGLTCTPDNCSEKGFLQHAASSKGIAIVYPDTSPRGLGIAGEDDAYDFGTGAGFYVDATKAPYDQGYNMYTYVTEELPKVLFTEFPQLDSNRVSITGHSMGGHGALTLFLKNPGKYKSVSAFAPIANPVNCPWGQKAFEGYFGSDKDKWNEHDATELVKKWKGPLTMLIDVGTGDNFYKQKQLLPENFLAAAKEAGVESEIYLRFQPDYDHSYFTIATFADDHVNFAAQYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L9</accession>
    <name>D4D2L9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024494.1">
        <property type="nucleotide sequence ID" value="XM_003024448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L9"/>
    <dbReference type="GeneID" id="9579716"/>
    <dbReference type="KEGG" id="tve:TRV_01324"/>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="280" mass="30942" checksum="33BAF6235650C5D9" modified="2010-05-18" version="1">MANSLSALYKYAIPAAVGVSFVQASMYDVKGGYRAVIFDRLTGVKEKVVNEGTHFLIPWLQKSIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPEVQKLPAIYQQLGQDYDERVLPSIGNEVLKSIVAQFDAAELITQREAVSNRIRTDLLRRAKEFNIALEDVSITHMTFGREFTKAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESADIISKAVAKAGDGLIQIRRIEASRDIAQTLASNPNVTYIPGGEGGKEGGKGTGLLLGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2R4</accession>
    <name>D4D2R4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000076">
        <property type="protein sequence ID" value="EFE43858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024469.1">
        <property type="nucleotide sequence ID" value="XM_003024423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2R4"/>
    <dbReference type="GeneID" id="9579692"/>
    <dbReference type="KEGG" id="tve:TRV_01370"/>
    <dbReference type="HOGENOM" id="CLU_1062420_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="30315" checksum="B24A7C80953FFAF1" modified="2010-05-18" version="1">MATILDPKSKLQTFNKASWREEAEDLRDGSPEADIDWAQEYRQCFEDIFSYYRVQYPDIIIPEHTRHRTLFEYLRDKGFASKKQKDLQGKSREAIVFSEVAEYLGEGTVQDISILEYWKVNSKRFLIVSMMARDILVVPPSTVGVERLFNIARDVKYFRRAGLNPQTVRAIMVELASNRLDRDRLVANDPSEAEDFTPMASLRHIQRLDQVMEPTIMEFSNREYISDTEDPLPRRQSTAPINEEEENGGDASFVVDCSLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2R6</accession>
    <name>D4D2R6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA excision repair protein Rad16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_01372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024409.1">
        <property type="nucleotide sequence ID" value="XM_003024363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2R6"/>
    <dbReference type="GeneID" id="9579690"/>
    <dbReference type="KEGG" id="tve:TRV_01372"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="379"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="721"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="809"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="110617" checksum="6E99B0FE84166D23" modified="2010-05-18" version="1" fragment="single">RFSKLRVDKTEEIRREEEEKEIRRRREEEEEVLLLHGWIHAKSLPENPLGQAATRRSSRVASASKGRDETTREEPERSMSMPKRQANIMVAIPVKKGSLGASASTSTTSTSASSSTTGRSPAGYSTPATTATTTPNNETELSTRASRRVNATARALELRNSSLGLNSRKRPANAGSSRPNTIDDEKLAAALQAEEYNARPTAKKQKTARGSKAKPVIPDSESDAEPESRPESDSDSEEWFSTNEEAIKNTPKKWSRRTPKDYRAVSPSDSDLNSVVGMVTDSMDSSQLSDISSIADSEESDDLVPNGRYRRLERFIAASKPTRAQKERIKLERQHPQITDMWEKLEQKPILSPPPAAQPEGINRKLKPFQLEGLSWMLAQEKSEWKGGLLGDEMGMGKTIQAVSLLMSDYPVGKPSLVVVPPVALMQWQAEIESYTDGKLKVFVYHNANSKVKDVKAKELKTYDVIMVSYSGLESMYRKETKGWKRDGGLVKGTSMLHSLDFHRLILDEAHNIKQRTTSVAKACFALKSTYKWCLSGTPVQNRIGEFFSLLRFLEIKPFACYFCKTCPCEALHWTQDAQKKCTLCNHNGFNHVSVFNQEILNPITEHRGDDEKRKDALKKLRLLTDRIMLRRVKRDHTSSMELPPKRIEIHREFFGEIEQDFSRSIMTNTTRQFDRYVSRGVMLNNYANIFGLIMQMRQVANHPDLILKKHAEGGQNILVCCICDEPAEEPIRSRCKHEFCRQCAKEYMASVQYGSEPDCPRCHLPLSIDFEQPDIEQDEGGVKKNSIINRIKMENWTSSTKIEMLVFDLCQLRNKKRTNKSIVFSQFTSMLQLVEWRLHRAGISTVMLDGSMSPVQRQRSIDYFMKNVDTEVFLVSLKAGGVALNLTEASRVFIVDPWWNPAAEWQSADRCHRIGQRRPCVITRLCIEDSVESRMVLLQEKKANMINGTINKDQSEALERLTPEDMQFLFRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2S7</accession>
    <name>D4D2S7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein (MoeA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024420.1">
        <property type="nucleotide sequence ID" value="XM_003024374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2S7"/>
    <dbReference type="GeneID" id="9579642"/>
    <dbReference type="KEGG" id="tve:TRV_01383"/>
    <dbReference type="HOGENOM" id="CLU_010186_2_2_1"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="314"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="569" mass="59200" checksum="3C05F46693AB41F7" modified="2010-05-18" version="1">MSRPVAGVRHKSIIITVPGSPKGAKECVEAVIKILPHACAQAAGADSRTLHAGGIQKLEKEAGIASHTAVSSKPDGGHHHCPHHGHGHGHAIPKAHTTAAERPSSNDPATGPTRRYRTSPYPMISVDEALKLISEHTPDPTVIEVPVDISLVGSVIAEDVFAAEAVPAYRASIVDGYAVIAPTSPGEGVSTKGQFPVASVSHAQAASMPPPLTPGNIARITTGAPLPENANAVAMVEDTVLVSTTPDGKEEAVVEILTADIKVGENIREPGSDVKLGSKILQKGDLITDVGGEIGLLASTGTKTVKVYKKPCIGVLSTGDELVEHSDPIKLTGGQIRDSNRPSLISCLTSWGFPTVDLGIAKDTSGHLEELLRDALRGASPSNPSGVDVIITTGGVSMGELDLLKPTIERQLGGTIHFGRVSMKPGKPTTFATLPFKPSSPDSNQREKRVIFSLPGNPASALVTLNLFVLPSLHKTMGLAQRGLPVVKASLTHSIPKDPKRTEYHRAVVGSSEEDGRLLATSTGITGVGQRSSRVGSMAKANALLVLEPGSGSIEKGQLVEALMMGPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D332</accession>
    <name>D4D332_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024352.1">
        <property type="nucleotide sequence ID" value="XM_003024306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D332"/>
    <dbReference type="GeneID" id="9579491"/>
    <dbReference type="KEGG" id="tve:TRV_01489"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="47"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="369"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="655"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131012" checksum="893D1DB795A3F013" modified="2010-05-18" version="1">MDADSLGTPFLDAWKKLKKNQRGYAAIRALSISLKWPIIMVVLPRSILIGLTVCQPILLNRLLDYLTESSEPKEKDIGYGLIGAYALVYFGIAISTGFYWYYHYRVLTMIRGCLVSAIGVKTLQLNTHSVEDPKAAVTLMSTDVERIIFGLRSFHEFWANAIQAGFLAFLLKRQLGIAFMVPLVIAILSSVLSIWASRSSDTYQTAWTSCSQLRIGTISSMLSSIKPLKMRGRTEILSSIIQNIRLQEIRLANRFRMLLVWTTGLGYIPQFISPPLTFLLFILRAKGNGQPFDSSRAFTSLSLLLILAQSLSQTLLDLPPLLASFGSSSRIDKFLSTESRVDIRHFPALLDEPRKTTFEKKYLPEQTIIEVTNGVFGWEYDRDVLHDINITIPRGQSTFIVGPVASGKSTLCYALLGEIPVSRGKVEIFANAKDIGFCRQTPHLTNETVQQNIIGFSLFQPSWYNTVVKACALATDIDSLPHGNETKVGSDGINLSGGQKQKIAIARALYALKPILLFDDVLSGLDYTGASHIFREVIGPKGLAQQHGITVIIATHATEYLPFADHIIALDKSGHVIQQGSFQSLRSQSGYIGSLAIAENFEKETVAHADQAAAKSVGASVNNEKSDENLPIRPSGDFRIYSYYFKAAGIWTSCLLLILVISYATLYNFPTYWLRIWVDTSTPSRPARLDDLGYWAVYTVLQTSALFLLLGVAYHTLIRFVSRAGSSLHKDILDVVINAPLSFFGSTDIGVTINRFSQDIQLVDNELPMALLNWLLTVFLALGQIILIIIASPWVGFAFIVIVPILYTMQNFYLRTSRQLRQLELEAKSPLYSNFLESLNGLSTLRAFGWTAQALETSYRLLDESQKPLYLLYMIQRWLTFVLDVTIAFLAVIIVALAVTLKASGGLTGVALTQVLSLNLILTSIIIAWTALETSIGSVSRIKHLTKYTPSEHKHGEVIQPPLDWPHRGKIDIYNVTAYYKSRPEFPVLRGLNITIEAGQKVVDGLDLANLPRNVIRSRFNMIPQEPVFIPGTVRFNLDPCSQHSDYEIIEALKKALLFDVISAQGGLDAEFQPSSLSHGQRQLFSLAGATLQKSKIVLLDEITSNVDQATDELMQKIVREEFKFCTIIAIAHRLNTIMDFDKVIVLDGGHIVESGKPQDLLWKDSVFKQMWKGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D374</accession>
    <name>D4D374_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024333.1">
        <property type="nucleotide sequence ID" value="XM_003024287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D374"/>
    <dbReference type="GeneID" id="9579460"/>
    <dbReference type="KEGG" id="tve:TRV_01533"/>
    <dbReference type="HOGENOM" id="CLU_038300_0_0_1"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="534" mass="57234" checksum="F21A2DCAAE16329D" modified="2010-05-18" version="1">MGSAIPVHPKDVLPAANISSSSLASSASASASASSSALLAQGGQAAAAGKQKSPPRGSPTANIGSLSECLGVLNFSAPPTQTPTRTKAKAKTKSVSNASLSPEIRPGKTPTPTVSTAGAGAGAGAAGGISSSPVESSPSVATTSNSLVTALPLSPFDEEIFEEFKEWGSQYLAEAGQSPLGDILAFCCESRSLVANCLMFQLTLHPEHEDKFEEYYAKCLRLFREDVCDTKAAMKDATLIAGILLCSTGMNRCMKWTVHLNGLYSIIQCRNAVSAPSPISSEILDSIGFFDLPTHVLGRATKPLHIWRDYCRGKSGIEPNSNIPFSLIDLLSMVGQPGVEMQLWTWQWDNNNSSSSSSSSPGRNAHPPSLLTRLAWDATRLAGIISSREYKLLNYAQTTDLSPSNPYQPTQSDDGCPATPFLVEGILSNLTTILTTESQHQHHQHQPPQEVCEVLNLLLYPAFVAGSQHTLLTPLHKQRIEAFWQELFPDMGADGPGMPHLQVPLDILRDLWRDARGRTVDMIAKERGVEIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C1</accession>
    <name>D4D3C1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024230.1">
        <property type="nucleotide sequence ID" value="XM_003024184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C1"/>
    <dbReference type="GeneID" id="9579268"/>
    <dbReference type="KEGG" id="tve:TRV_01580"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="56818" checksum="83177E30C66F7ABB" modified="2010-05-18" version="1">MLALIKTELKNPYRILRELDSHQWLMFGVGFIAWVWDAFDFFTVSLTITEIATEFGVTNSEVSWGLTVTLMLRSVGAIIFGLFADRYGRKWPMIINLALFVFLELGSGFCHNLTQFLAVRSLYGIAMGGLFGPAAATAMEDLPYDARGIASGLFQQGYGTGYMLAAIFYRAFVPTTKYGWRSLFWFGSAPPILIIIWRWCLPETRHFQVMKAERESRVLAEEAALQPSGSSDTAPKSRMSGLRAFWKESAPGLKENWFLMVYLVVIMTGFNSCSHGSQDFYPTFLKDQVGKTATQTTVIVVAGTLGGVIGGTLIGWISTFLGRRLTMMISCVFGAALIPAYILPRSNALIASSFWQQWFIGGVWGPIPIYLSELSPQSLRGLLVGLTYQLGNLASSASATIQAIIGERFPLPDGPHGKKRFDYGKVMAIFMGAVWVFLLVLLFLGPEMSQEERDEEEAAAKELERLRREGKTLEEIGRERAGLANVKVLEDEDVKEPTTHHMDEVPVEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3L5</accession>
    <name>D4D3L5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024176.1">
        <property type="nucleotide sequence ID" value="XM_003024130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3L5"/>
    <dbReference type="GeneID" id="9579214"/>
    <dbReference type="KEGG" id="tve:TRV_01675"/>
    <dbReference type="HOGENOM" id="CLU_1348630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="203" mass="20564" checksum="10E22C9BDD1AD206" modified="2010-05-18" version="1">MSSSDGFCSSLSFSPGELGQVYTMEKPHPISSNVGVSSNAPTVQSPILTSPRKNSAGKASLAAIGTPAPTPTAVPARAASSGPATPSSATSKAANVVNNPTPILGTVPSVTATNSSQPFSTPPETPMSSHSATNSISGSVLGKRDISTVSESEKEDSHDKDEDDQTGNNAAQREPKRKRIAPTLVSSASSGMPNSEDSNKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3M5</accession>
    <name>D4D3M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024186.1">
        <property type="nucleotide sequence ID" value="XM_003024140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3M5"/>
    <dbReference type="GeneID" id="9579224"/>
    <dbReference type="KEGG" id="tve:TRV_01685"/>
    <dbReference type="HOGENOM" id="CLU_434249_0_0_1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="427"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="630" mass="71321" checksum="89F060121482BB74" modified="2010-05-18" version="1">MTNDEDEDGDEDKTMTRVEGRGRQKRVEDTGHSHYEACNLVIRIRPLLFCLPGRGLVSATSRRFFPPRRSPFFDFNFNFNFTNFNFNIACISFSLSLLQPASWHPGLDRIDRTSCSVKQTGCSPTRTGRQLGLAWNRNQGPRAVLAAHHLNISFSSPSSWTGRHSDSKRPSPIDLTLSLSLSLSQPPASINHHIRFDDDDTDCSVRKEHRLKTFARLKTVRLACVAADKKVEHSPGTIQITHLFAHAFVVNANINASITASSSPSQPARPRPAIALAAAVDSASLKFRNLLHVLSVTPMKYENPGLLDEALSHVPLDRLYAEAEEECQILQAEAASMGENVKPTWGYQDCVIKALLSRGRWFKRSFFQFINNPPCSRCLRPTLLQGMTPPTPDETARGATRVELYICSEPSCASPERFPRYSDVWTLLQSRRGRVGEWANCFSMLCRAVGGRVRWVWNSEDHVWTEVYSEHQKRWIHVDACEEAWDNPRLYTEGWNRRMAYCIAFSIDGATDVTRRYVRNPAKHGLDRSRAPDEVLLWVIHEIRRMRRENLSKEERRRLVKEDEREERELRGYVAQSIATELSRLNPNGVSAPAPGDEVKVPVSAAATTTGQSGVERTGQPNPDPSRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3W3</accession>
    <name>D4D3W3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000094">
        <property type="protein sequence ID" value="EFE43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024077.1">
        <property type="nucleotide sequence ID" value="XM_003024031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582769"/>
    <dbReference type="KEGG" id="tve:TRV_01776"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="616"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1698"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2215" mass="245767" checksum="C45CE4A14980E8FA" modified="2010-05-18" version="1">MGSQDTDSDDLFDRSLSSSHSSSPPTPAAPKSSIYQTNTLDSVWKWNANAPPTLNACVHELVQTRVDLTPDAIAINAWDGVLSYQQLASEAAHFARQLIDSYQVVPGEKVLVALERGLLIPVAVLAIIQIGATFVLLDTASPESRLRQIAERTCARVTVTSQSLTTLARRLSSSVMTICKRRSEPSFIATPGTTSSLWPADPSSILYVVFTSGSTGNPKGVEVSHSNFVSGLQQQSELYQLSQDSRFLHFASYSFDAYVHEILITLTQGGCLCIPSDTDRMQRLSAAMNEMQVTIALMTPTSSQLIEPDKVPTLQTLVLGGESMSRAVIERWSPYVRLINAYGPAECAVVSTGYVVDVHRCLETGIVPIGRGYGCVTWVTHPDNVNHLTPVGEVGELLIEGPNVSSGYLSDPEKTAASFIEDPKWLIEGSPFACFEGRHARLYKTGDLVRYTEDGNLVFVGRKDTQVKLHGQRIELEEVEHQIQSFLPGGKKAVAEVIQRGGQNKAAQLVAFIEVPDRELESNRESFTQEASGGGLDPIFRAVDAEFQQLEETLLSALAERLPSYMVPSVCLPVARFPETPSGKLDRKYLREAGRGLLDVLLQRRVAYNSSQPSWKPEQAVMRGLWSLNLGIDEDEILLDDHYFRLGGDSVSAIKLSVAARRRNVSLDVKDILGHPTLLDMAARMREGEKKTDEQTDLMAPFSLIPKDDVPSVIEEVAKACRISEAQVQDIYPCTPLQEGLMALSERQPGQYIACEVLKVHPRADLTRLCAAWATACNLNAIMRTRIVQTSSAGLVQVVVRHDLDFASRDTIGACRSDNVEFGLGSPLTRLRVVQSSSQSESSYIVLLAHHAVCDGWQARAVASQVEEIYEGRYGTPPPGFNTFVRYLSRVDNDKETEYWQRALGNGNVPSHFPTIPPGKTAGWANQTQHREIWVDFESAERNTEYTLSTYIRLAWAFLTSKYTTSDTVVFGATVTGRNAPVPGINDIVGPTIATVPLKVYLDKNSTVRACLEAMHHQAVEMIPYEHTGLQRIRKLGEEVEAACDVHALLIIQPTPTAQDPMAPQNRVEDEEDFLLAFSNYPLVVECTLPGPGTGLGVRVAFNDQITDMEHINRMLLHLEHVLKELSCKPDHELRDIDIIIPQEVEQLQAWNGPLPQSQGRCIHDLIWEQLASQPSAEVVYAWDKSLTAESLSHFSLRLTSYLQSFAIGPEDYVPLFFDKSSLAIISILAVLTSGSACVTLDRKQPDQRLIEIVRQTGAKYMLVSEKHKGMLEIDGVTQIVISYAELEKMPLPSHGEIFSTTRARPENPAFLIFTSGSTGKPKGIILEHRNLSSATLAHAANMNIVRGARVLQYASPSFDVSIYEILMTLAMGGCLCVPSDYQRMNTPSEFAREAKAEVVIISPTAIRSMSPDEVPLLKTVVLVGEAIPRDVVETWSRSSLVMNGYGPGECTFCSTTPIDTQKWDLATVGRAGGCVFWLTDPTDYNLLAPIGAVGEILIEGPVVGRGYLNDPERTAASFINDAKWLGRFRENGRGRLYRSGDLGMYNPDGSVVYMGRRDMQVKLRGQRIEMGEVEFNLQRLLPNATIVVEVVKYGENERVTAFIALSQMEASTTVTTATSPSSILLPPTQRVVQAAQLSADLGQVLPSYMIPSVYLPLARVPTTSSGKIDRKTLKHAANSMSLVDIMAYGEEQSSTTEPSTTAELALQKAWASLLKISPDTIKRETDFFQAGADSVEAMKLVSMARREGRTLNVAQIFASPQLCDMALWWDSQRDNDDDALEKEWPAFALLDDSETETFIERHICEPHSIPREKIKDVYPATYDQVLVYSINHTVYAHFEVDERLDRAHIVESWLQVVRQHDILRTVLVPAGNDQYWAVVRTGDVFDVDYRTIRHDSELHQIIDTDHASGLHPGSFLGKLFVLESANNGKAVIILKMNHTIFDGSCFALYWSDWQSAYERGIVPTRLQYQDVLCSRRRIDSYAAARQYWGDMLHGLEMQSLPTMSEDSTPERMGDPLKISRCLTHISPPAEVVLDSFIKAVWTVTLASLSGKRDVGFYHISNGRRLGGRRTEEAAGPLMQLYPMRAQLQSDWRLVDLCRFLQEQDMRNLPHELLTTAELCEVAGCSDTFSGTLVDHVKDDIESGLSFDGIQCGLSMEWRGENQDENICFVRSKGDQLEVTLFTSWNVHKVVAEEVMDIYCEKLQYFSSHPEATIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D454</accession>
    <name>D4D454_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_01868</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024006.1">
        <property type="nucleotide sequence ID" value="XM_003023960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D454"/>
    <dbReference type="GeneID" id="9582699"/>
    <dbReference type="KEGG" id="tve:TRV_01868"/>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="101"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="259" mass="28106" checksum="5587262EF62A2034" modified="2010-05-18" version="1" fragment="single">IYICPLRRSTLLLPPSPFTPSSMSLPPSADNQQAYRDKSNASSTAQVAGDAAPSASRTAELASLKVKLRSSLRQFPDFPSPGILFEDILPIFADPALHESLIRGLELHLLETYGADQKPDVIVGLDARGFLFGPTLALRLGAAFVPVRKQGKLPGPVITQEYQKEYGSDFFQMQSDAIKPGQKVIVVDDIIATERKKYPSMLNLNVFLPGGSAYAAGSLVQKLGGNLLGFVFMLELDFLKGRDKLPAPVYTLLATQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D493</accession>
    <name>D4D493_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023966.1">
        <property type="nucleotide sequence ID" value="XM_003023920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D493"/>
    <dbReference type="GeneID" id="9582659"/>
    <dbReference type="KEGG" id="tve:TRV_01908"/>
    <dbReference type="HOGENOM" id="CLU_019106_1_0_1"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="591"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="665" mass="74967" checksum="452F0F2FF4EFED70" modified="2010-05-18" version="1">MAKKRKAGGTALAHRSKNPIEDENSRFAADARFENSEDEFEAGRDRVLLEERPEVKRRRKLEEDERLLQLSDEEVHGYLSESASEDDYDYGGEEGEEEVEKGDKSAQSKKKLPKLRRREELSPDLFDDGKKPEEDEEEGITAWGASKSDYYNADTIETEGDALEEEEEAKKIQLKKLQSMTDADFGFDESEWLDSIIGDGETSRDSIAHGKTITEVLPEIQIPDDMSVEERLDILSKRYPEFIPLSRDYADLQPRYQELSVAADGSRKSRKETPDEKTPLSVLQFRALAAYLGVISMYFVLLTSPARNGTESCLALPPAELREHPVMEVLVACRKTWEQVKDLQEIEEAPSDIEKEEEISIAIPAKKSSLDKPSKVAKAAKIPKKSKAQKLMEEAQAVVESQRAEKLNQTELGLQELSRLLEQGNSSRLASQREPRLHDDDSDFGDETRLTAHEAAEKAKKKKSLRFYTSQIAQKANKRDAAGRHAGGDTDLPYKERNKDCQARLNEEAQRRGRMEANEKERLGGDSDEDDYQVAREVRGEMDGSNSDDYYDMVASRQKQKKADKKALSEARALAAKEGGRVEIQEEIGPDGKRAITYAIEKNKGLAPKRSKDVRNPRVKKRKKFEAKKKKLGSMKQIYKGGEGRGGYGGELTGIKKNLVKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4B4</accession>
    <name>D4D4B4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023879.1">
        <property type="nucleotide sequence ID" value="XM_003023833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4B4"/>
    <dbReference type="GeneID" id="9582511"/>
    <dbReference type="KEGG" id="tve:TRV_01929"/>
    <dbReference type="HOGENOM" id="CLU_943951_0_0_1"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34981" checksum="9B482B76696830F8" modified="2010-05-18" version="1">MTLDRPLSEGPYRAAANGEENHASSEAEQDSARYSDASARRRNGQTGRKVRVFKIRMRATAAKVVVDGRVFECTPYWRAKAYYQRRSHPILWLFFSSIFFLSSFLLLLESRRFFFLLFWTLFFPSKKAKKKRRRKRERKEEEKKKIRGGESSRKGRQEDRREEREKMSEATHDSVEVASEKKPAPTSAIESSKPKGMRKNGKNWHAPKKAFRPTAGQTSYAKRLEERKAMAVMKEKEKEMKEEKEATRQARIQAIKDRRAAKEEKERYEKLAEKMHRKRVERMRKREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H6</accession>
    <name>D4D4H6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023871.1">
        <property type="nucleotide sequence ID" value="XM_003023825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H6"/>
    <dbReference type="GeneID" id="9582482"/>
    <dbReference type="KEGG" id="tve:TRV_01993"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_2_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="515" mass="56051" checksum="E682530BBC38557F" modified="2010-05-18" version="1">MTPYFMITIFFTLFTYPAKQWLTAILPTGIPTLPRYHLVICPSSIAINHVATGINLILSALGLLAQSLSLDEVRLELGPQLSESARISENGQEFARWSEYYSPTPGVVVSVASEEDVAVTFFAQSGAHGFTTTMDVPPDGILINLRQLNSVTFNDERTKVTLGGGVLISEIIEAAASNSTLVLTGNCNCVGAIGAILGGGYGNLMGIYGYGVDNILSLNVVSGDGVLQTVTDGDDLFWAVRGAGPNFGVVTSVIMKAYPVQPAGLYAWLGTLTFTGDKIEAVTKAISELELKPEMNLLMYFLDARAPSKTPTIVVTPFYHGSEAEGRAAFSSLLNLGPTLDTTASTHYTHWNDGSQSACIKGDRKPSYCSGLAKIDPGTWKQVWDEYVTWVSSNDGKSRNSTVILEAYSMDRVQSFPVNSSSVPWRGRIKFNALVVPWYKDEDLDLAAESYGRFTRSLILSTSGLDPPATYVNFAYGDEEPSEVYGHQLPRLQKLKAKHDPNNIFDQSFHIEPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4P3</accession>
    <name>D4D4P3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000106">
        <property type="protein sequence ID" value="EFE43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4P3"/>
    <dbReference type="KEGG" id="tve:TRV_02059"/>
    <dbReference type="HOGENOM" id="CLU_221788_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="24" mass="2755" checksum="CC7E9528B3667EA2" modified="2010-05-18" version="1">MLTSEPKEDEEDEKEEKKASHAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4W1</accession>
    <name>D4D4W1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor TFIIA complex subunit Toa1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023741.1">
        <property type="nucleotide sequence ID" value="XM_003023695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4W1"/>
    <dbReference type="GeneID" id="9582276"/>
    <dbReference type="KEGG" id="tve:TRV_02128"/>
    <dbReference type="HOGENOM" id="CLU_030027_4_1_1"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="411" mass="45096" checksum="B5BDBB140AE6A3CA" modified="2010-05-18" version="1">MAGWQSKLSSLGVAHFPWDPAPQPPVSQPQATQQQSPIPPPSTIPSNDARMNPQPQLHPQQQQQQPQQQQQQQQQQQQSHIPQHAGLQSANDHPSGDTFVKAEGGFSPPPPGPPAGTILAQQRAANALHQKYGNAAANQVQHLQSHSQAALSLPGGQPRYNPPPMSTSKPQDFRPPQAQAQIQPQGQAPGQQQTQPQRLPQTGIQNSQTDGASDDLSDWKAEVQRRREAAAKNGPENDRRLRDLVESRNLQLEGGGLLAPLHERYPNANGKKRKIVKFDDLDSLSNQTGASSVVPSSSTPTEAPSHPQFDGPDDYPVKKDDDEDAINSDLDDPDDLLDEEQGEDDAVGQVMLCTYDKVQRVKSKWKCVLKDGILTSDGKECVFPSSTIQFIFSNLSSRYVFHKGTGEFEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D526</accession>
    <name>D4D526_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023687.1">
        <property type="nucleotide sequence ID" value="XM_003023641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D526"/>
    <dbReference type="GeneID" id="9582235"/>
    <dbReference type="KEGG" id="tve:TRV_02196"/>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="541" mass="59013" checksum="654EE491C4B58007" modified="2010-05-18" version="1">MVLLFTLPTTSHIQFSPFIHSHTHPSLPQASSTARHGLRAALKKHKRLSPAQRASHLPHVLIALNEYIPYLSAISRGLSSNSWREDATGGGEEGGGRWQGVEDIDILLRAEIEVEWRPTLSSMSTIRMLRQAAMRGNDSSSASSSSRVKGRGLDFEIAFVLSTLAYVHSSLARIEYLTTLYSANTPTVEQKATAIQTATKHLLQASSIHSYLATFSPVSISAPSNTYTPGDLGAEMVHIPIPDLDPSMQSALSSLALAEATLLAVLKDDAFLSACIQSRNKNDTEWMIKSPDIPKVRTLLFARLCVRAAEYAEQAAASAVMLQKGKGSAASHGDAGSERKIDSSLVNYMSILARVARAKACRFFGIDAEMSGKVGEGIAWLRAGRDMLGFKGLTAETGADQSSKGKLSGFSRLKREWSERREEKKIEKVATSSKAGELVTDIDYGDDAGREEEGRVIDMLEKKWTKMNDTVNTQSIPSPSSYASKLPSGRDIHTPPGPYVPPMLEPAELERLRGPIEPPDYNIDVESSEGEDDKETSRSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D527</accession>
    <name>D4D527_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023688.1">
        <property type="nucleotide sequence ID" value="XM_003023642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D527"/>
    <dbReference type="GeneID" id="9582236"/>
    <dbReference type="KEGG" id="tve:TRV_02197"/>
    <dbReference type="HOGENOM" id="CLU_016434_1_1_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="162"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="57740" checksum="CDC9B4BE8B6E10F1" modified="2010-05-18" version="1">MAGRQILKLTIGKKAAQPSQSSQAAPQPSQKSPTPPPPSASSTPAAAPKLKLKLGLKQPAPQPEQKQTPAKAKKAASTKTPKETPASSSSKKRSRDAATDTNGKASGAAAPAEGAPIKRFKLTTKPKQPTSLRIKNKGAPPVRPRGSGYDSEASDTEIDPALEEEFILRMEPGDDCEYLRKAIEEKRFGPRSLGGADVSFKSLTRDGRRATVTIRGNIYAATLVDLPAIIEGLKSWDKRGWYKAADICQMLLVLGKVKTEEEAHHYPLPKDVDPATFQYAHGLTPPLRWVRKRRFRKRISNRTIEAVELEVARLLKEDMAAIKPPDFEIMDQSQYARENQTEQDGFEEYDDEQDAEGEFFDESQQYEEQQYEEPMEMDDDLAAEMEAELAAHADAGSVPASATPDVSHAGEDSHEPDAEGELEIGTPQTPHTPLHPPVESSGDEDESGMSAAEDANEDLDQDALEQQRQLQEQLEEIAELEADVQAETRRWEEMNNPILKAKLGKRVQNLKQALELKKVSIGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D531</accession>
    <name>D4D531_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023692.1">
        <property type="nucleotide sequence ID" value="XM_003023646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D531"/>
    <dbReference type="GeneID" id="9582240"/>
    <dbReference type="KEGG" id="tve:TRV_02201"/>
    <dbReference type="HOGENOM" id="CLU_561355_0_0_1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="437" mass="48778" checksum="7A5C9080527CA6D0" modified="2010-05-18" version="1">MKAFFDNMGCWPPRNTVFYTYAKLSILREESNSTYAIRTIRETVKALLQAEKTTSHELKAEKTLLLVKAACSAVTTLTISKAFSGYCPWSKGYRCTTQTPKSLIHVLSAAVHDDNIRLVAELLKQGVSCNQSSQVFGTPLCIAASRRNRKMINLLLKFHADPSYFYRLHDRSHPRTPLQAAAFAGHEEIVDLLLQPNLGVQRSGDRFYRALVFAARGGHFNTFKQLVDAAAPQVDPLFQWADCLMAACESGSIYLVRFILFKGGDIECMRRFETPLICVARKGYHDIARVLLEAGADPDYDSQHQSAITMASKYGHLEVVRVLLQFGAYVDAKFGSIQNAAAGGHKDIIQLLLDHGAQVSGREPDRWRQTGQQIGQWAYRKAISNGHYSLASWLLTLGVDMDNHVDTVYEWSSCDETPIITSDDEESLEGGRVSEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D540</accession>
    <name>D4D540_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023635.1">
        <property type="nucleotide sequence ID" value="XM_003023589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D540"/>
    <dbReference type="GeneID" id="9582181"/>
    <dbReference type="KEGG" id="tve:TRV_02210"/>
    <dbReference type="HOGENOM" id="CLU_010026_1_0_1"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64053" checksum="C11087A5AFD3D8AD" modified="2010-05-18" version="1">MVKEDSTRATSPAAGPDAPSSPGSSLGPVDEMAPASAVHRSAPPEKPEAVRRRSLIVLTFWLIILLLGLPMWWKTTSIYRAKLPLNEMENWAAGKSCRPVFPLHIHVHTPGLNIHEAESLVQAAQHALDDLNDFSAHHLRLRLVKTKENPSSETSTANGAVGERALVLRLIPRTNITAISSDLHPYSERLDIFYPSSQGQPQTTSHSPLTTFIANELRTLFNEEKATLEYILSQSNSATMSSKHVAQGAVNKDQRANVLSPAIQPLLLESIASRVKNSFKYAETYHLSFSLFTPGPAPSAWDIEPALKEYLSPLLNVFAPISNFSVDTQVQVYAKFSPTATPPEYDESKAAWTLKQDDLSGFINAAEWPLNPSIGGGPTINFILYVPSPAQSPLVVKENAATSWLIPQWGGVVILNPPLSNISELQHPPHLSREALKPAMDTFSHQLLTLLGTPTSPPSLPLRLQSLIRIHTASLLLSASSTMGSLARLTLSLPSIPIPVTVANSVSHTLSHLSSTCEMLHQGAFESALAHARVAEKEAERSFFEKSMVGQVYFPDEHKVAVYLPLLGPIGVPLVLGLIKEIKRMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D594</accession>
    <name>D4D594_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02264</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023517.1">
        <property type="nucleotide sequence ID" value="XM_003023471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D594"/>
    <dbReference type="GeneID" id="9583537"/>
    <dbReference type="KEGG" id="tve:TRV_02264"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="151"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="354"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="52322" checksum="011ABACB8AC883E5" modified="2010-05-18" version="1">MSYGGGGYRDHQGGGGGYNSRGGGGYQGGSSGYSNGHSSGPSYGGGFGGGYGGGAGGDRMSNLGAGLKTQQWDLSSMPKFEKSFYKEHPDVSARSTQEVEAFRKENEMTVYGKDVPRPVQTFDEAGFPQYVMSEVKAQGFAKPTPIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQAEITKFGKSSRIRNTCVYGGVPRGPQIRDLTRGVEVCIATPGRLIDMLESGRTNLRRVTYLVLDEADRMLDMGFEPQIRKIISQIRPDRQTCMWSATWPKDVRQLANDFLQDYIQVYIGSQDLSANHRITQIVEVVSEFEKRDRMIKHLERIMEDKKSKVLIFTGTKRVADDITRFLRQDGWPALCKLLTMFTLFSFMNLNHLLIYAGLAIHGDKQQNERDWVLNEFKTGKSPIMVATDVASRGIGMINLQPPFLPFSKPISIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5K0</accession>
    <name>D4D5K0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023478.1">
        <property type="nucleotide sequence ID" value="XM_003023432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5K0"/>
    <dbReference type="GeneID" id="9583498"/>
    <dbReference type="KEGG" id="tve:TRV_02372"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="245"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="507"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67054" checksum="EC5BE5837A6C7B88" modified="2010-05-18" version="1">MARQVLESDLLSLHRAESNNSSPRWQPQEEFVVSDVFMPQTPEPEQADEADLGQSWATVVSEKPSTTSNFRMVPGDVSPMRPNPKSGGLNPVKKKKNKKKKLPKDKNAVSHVVEAPQPGCETPPAYFKDGRSSISPRLRPVGAFKNNFESRPPSAHGISALSIQLDALNVGSARPSGSEASKKGSETSSCGSVISESDHTEILTTYEVPLGDDFVSLDLNNEGPKAMDGSEKKAILNRKMTAADFDSLTCLGKGTFGTVLLVKQKANGALYAQKQFRKASLTVHKRLVEQTKTERAILESVNRHPFVVKLYYAFQDHEKLYLILEYAQGGELFTHLAMERMFSEETASFYMAEMVLALEHLHCNVGVIYRDLKPENCLLDADGHLLLTDFGLSKVAVDDDDRCNSSLGTIEYMAPEVIMGKPYGKACDWWSLGALGFDLLTGSPPFKGNNHAKITEKILKQKLALPYFLGPDAKDFLTRLLRKEPQKRLGYHTSKDIRTIKSHRFFRKIDWKALEKRELEPPIKPVVTDPALAENFSHDFTSLPLSPVLTTKSGPFSNAEDAMDVDGEGATDSEMGGIQPSEDPFGGFSFVAPSSLLESGLAIGNMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5L9</accession>
    <name>D4D5L9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000123">
        <property type="protein sequence ID" value="EFE42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023468.1">
        <property type="nucleotide sequence ID" value="XM_003023422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5L9"/>
    <dbReference type="GeneID" id="9583492"/>
    <dbReference type="KEGG" id="tve:TRV_02392"/>
    <dbReference type="HOGENOM" id="CLU_2279486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11383" checksum="75A98428F4A85612" modified="2010-05-18" version="1">MLVFDPRARTSAVQALAHEYLAPYHDPTDEPEAGERFDWSFNDAELPVDSWKIMMYAELLSPLSPSINNNTNNNNTTTTSPLTIPMPPPPPQIPLTQPPQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6F5</accession>
    <name>D4D6F5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023158.1">
        <property type="nucleotide sequence ID" value="XM_003023112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6F5"/>
    <dbReference type="GeneID" id="9583206"/>
    <dbReference type="KEGG" id="tve:TRV_02680"/>
    <dbReference type="HOGENOM" id="CLU_017389_0_0_1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="338"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="581" mass="63401" checksum="0068FA6C763245C9" modified="2010-05-18" version="1" fragment="single">RHRERYGPYLNRLETHLQRDRQGMGDISATMIKSEPDEPNNPHQFMMSPSAYGIPTPSYGNQFGGSGTGTGTGAGANGSEGIDPSELTMQQNGFVSHHHPFGSQNLSSSFTLGNAGIDTDELLDLEINGQNLSRDDGLDQRQPTAISMSHQGQMSHIYSSTPDGAPIQSPFLRSSFNYDQFRQVQHTPQATSPHMNAMNVHFDQNYSVAGKAARNSFHGDARSPVTPKTPGIGIGGLNINTPDSGSYSSQPIRAVSLQSQHQKSMSGQWNGTPGSAQSLMESPISSPGGHHASHHANIHEMLKSAKHASLPAKVDSLHGHHHSSSSQSLESQEAKRRRRRASHNMVERRRRDNINERIQDLSHLVPQHRLEDEKIRKQLVNNSALSTSSGANASSPPNHNPATSLLAGPSARRATAGNITMGLPIEEKEKGPNKGDILNGAVGWTRDLMWALHRKLEQEDQLAEYIASLGGQWPFEQTEEDRRMRTEVFDAMEANDGVNFSYSRGVGSGLRVPKHTTISGESLPQSNSPSQDQSQPQTQPQTQSQTQTSGNSPGFNSSQFWNSSGHIGLSVKEEDEYAMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6S2</accession>
    <name>D4D6S2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023052.1">
        <property type="nucleotide sequence ID" value="XM_003023006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6S2"/>
    <dbReference type="GeneID" id="9583072"/>
    <dbReference type="KEGG" id="tve:TRV_02799"/>
    <dbReference type="HOGENOM" id="CLU_1434112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23171" checksum="CC649B42EF149992" modified="2010-05-18" version="1">MGTRNAKTGGKEKAKKGHPRARENIMMYTSMAGFLSFFSPSSFMGIQQQCHTIITLWILLSMMLFRLSGQGAGTVLLTGSFLRLGNDQQWRVIPCFFLLLLLLRLSFFANDDGLAGIFAKRSPDISKTRPTSPGPSRCKDCDVDVLDAAKVHLCLLVCYPSAPLLSSHPPFSLCQGQSRASETQKRGTTRGKRKQAERSAVEALAGATVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6V9</accession>
    <name>D4D6V9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023015.1">
        <property type="nucleotide sequence ID" value="XM_003022969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6V9"/>
    <dbReference type="GeneID" id="9583035"/>
    <dbReference type="KEGG" id="tve:TRV_02836"/>
    <dbReference type="HOGENOM" id="CLU_081054_0_0_1"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="277" mass="31631" checksum="27BB58FA04CC0CF1" modified="2010-05-18" version="1">MSSTWIYKADETYLPADVYNTLPHVNLAKVDEEERKWAAARSTLLQMISDHGLEDVFSLHLLHRHYDLPTNHAMVYEQSPYPPSDDLPFFEICRPRCIHSLEAARKPRGKFFFYRQDTGTMSAYEYTTEVGPDITSTAYESFINDFCRELLKLKAENVFALSLSSPSENSRILYETEVPAYKATLRLEKADWVPDGFNTDWVGSAGDMGGVYPRYVPRGASKPADKHSRRRNSEHHRTEFIGPTDSTSVGVIWDGKNLDNESVAYSVLLKARELIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Z0</accession>
    <name>D4D6Z0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_02868</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023046.1">
        <property type="nucleotide sequence ID" value="XM_003023000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Z0"/>
    <dbReference type="GeneID" id="9583066"/>
    <dbReference type="KEGG" id="tve:TRV_02868"/>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="17">
        <location>
            <begin position="524"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117043" checksum="C685F6AEDF549538" modified="2010-05-18" version="1">MLRSGGRLGKLGSFRAPAALSRHAQPGSSLGLKLKDRRWASTSTVTALESYPAAGEKLHGFIVQQKKHIPELHLSAIHLKHEKTDADYLHVARDDKNNVFGISFKTNPPDATGVPHILEHTTLCGSEKYPVRDPFFKMLPRSLSNFMNAFTSSDHTTYPFATTNKKDFQNLLSVYLDATLHPLLKEEDFRQEGWRLGPENARAAEHSSQDGPSSEHAKDDDIVFKGVVYNEMKGQMSDANYLYYIRFREQIIPALNNSGGDPQHIPKLTHQQLVDYSRSNYHPSNARIFTYGDMPLADHLAQVGEVLNGFEKKANPLDVKMPIDLSSGPTNVTVSGPTDTFASEDKQTKTSVSWHAGDSRDNVELFSMGILSSLLLDGYGSPLYRALIESGIGSSFTPNTGLDTSGKVPIFSVGVNGISEADVPDVQKSIQKVFEEQLSKGFNDEKVQGMLHQLELALRHKTANFGMGIMEKVISSWFNGSDPMKDLAWNEVINEFKKRYGKGGYLEGLMQKYFMNDKYMAFTMNGDPTYNDSLVEREAARKETMMKELGQKYGSIDAAKEQLKKEELELLNVQEAAQQADLSCLPTLTVKDIPRQREKKELSESKVDGVDVVWRQAPTNGLSYIQILNALDELPDHLRLLLPLFNDCIMRLGTSSRRMEQWEDLIKLKTGGISSSTFAASSPLALDRFSEGMQFSGFALDKNMPEMLSILTTLVNESAFRGPDAPRMIEELLKSSCNGALDAVAASGHRYAVNMASSTLSRKFWAEEQTSGLSQIQKMAQLLQDAQRSPERLQELIGHLQTIQAFALGRSSGLRIRVVCEAAMRAENEAVLQRWLSGLKSTTLAAAAAKTTLKPFPRPSSDKVLYDLPFQVSYSGLAMETVPFVSRSSAPLSVLAQLLTHNYLHPEIREKGGAYGAGASNGPVRGIFSFSSYRDPNPLNTLRVFSQSGEYARDRSWTQRELDEAKLSIFQGLDAPVSVEEEGHRYFLSGVTHEMDQVWREQVLDVSAREVSEAAQKYLVEAGQRSFCLLGQKKDEWPDLEGWEVKKISLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7J1</accession>
    <name>D4D7J1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022777.1">
        <property type="nucleotide sequence ID" value="XM_003022731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7J1"/>
    <dbReference type="GeneID" id="9581478"/>
    <dbReference type="KEGG" id="tve:TRV_03073"/>
    <dbReference type="HOGENOM" id="CLU_2998153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="57" mass="6355" checksum="A632B86D3D0A2B91" modified="2010-05-18" version="1">MTNDGLVRVTGTGREEEEEEEEEKKNERCEGGEAGQPARRERKSSSRDDAAPESAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7X0</accession>
    <name>D4D7X0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022683.1">
        <property type="nucleotide sequence ID" value="XM_003022637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7X0"/>
    <dbReference type="GeneID" id="9581342"/>
    <dbReference type="KEGG" id="tve:TRV_03204"/>
    <dbReference type="HOGENOM" id="CLU_049413_2_2_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="298" mass="32758" checksum="35E38DB5363DB8E3" modified="2010-05-18" version="1">MATQTTESEPIEHTIPFPEPTVIPPRSKHTHTLILLHGRGGVGRVFGAEIITTVLSAPSSDNTLPKRFPGLKFIFPSAKTTHSAQWDLYLPQWFDRGPIGSPAKEHNDLLYGGLRESTRYLRTIIKSEAELVGAKNVIIGGLSQGCAQALHVLLSYANDEHLPLGGLVGMSGWLPFKEQIADFIPRDQEEQEVGNEESRRAGALQAMNFVCQSVLDLPPITAEAATAALSTPIWLAHGNMDKTVTPNLGEAAAQTLEKLGWDVTWMLYDELEHWFAPMELEDMAIFLSTRVDIPESGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D811</accession>
    <name>D4D811_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_03246</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022589.1">
        <property type="nucleotide sequence ID" value="XM_003022543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D811"/>
    <dbReference type="GeneID" id="9581254"/>
    <dbReference type="KEGG" id="tve:TRV_03246"/>
    <dbReference type="HOGENOM" id="CLU_011815_0_1_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE41971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="346" mass="39500" checksum="F37439C2308C0382" modified="2010-05-18" version="1">MPNSKPSQTLKNHVNQNVKQVVLGNLQFKAWFDSRYPEELVRPGDGTLYVCRWCFRYTCDKQAYLGHMPTCTSKHSPLGTQIYEHGGYSVWEVDGEDQKLFAQNLSLFAKLFLDHKSVFFDVSSFLYYLLVYTNPADPDDYHVLGFFSKEKMSWDANNLACILIFPPYQHKQLGKLLMGISYKLSAWEWKDGVIGGPEKPLSEMGHKSYVRFWEERMARFLLHVSSSGVKDEQPKTSNAKPPPAKKYRKKPPRERMSIQDIGQATGMLAEDVLTALNSMGVVQAEKKPVKRKRASQPEGDDDLPTAVIKRSNVLEWSKSHKVNLRDPVHDEGFVGEWATSSDKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D818</accession>
    <name>D4D818_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022596.1">
        <property type="nucleotide sequence ID" value="XM_003022550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D818"/>
    <dbReference type="GeneID" id="9581255"/>
    <dbReference type="KEGG" id="tve:TRV_03253"/>
    <dbReference type="HOGENOM" id="CLU_052828_2_0_1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="364" mass="39515" checksum="704241CF289B8D0B" modified="2010-05-18" version="1">MATPAQCYFCFETLAASFDGGKPPKLSVVEELWAEFETAKALALRAADNEDLEGGGSVEPPVDTDGQEPQDDMDKGQPFSSTLQPPSIRRLQSAASSGSSSVSTSTPPALSTSSSRSALTSNTSISSSPSPNTSSIFSPHKPSYSETLRRTPPDASYPLFVTWNTVSRSGYKSLRGCIGTFDAQELSSGLKSYALTSYGTTYKESLLKAFGDTRFSPIPLQLLPSLSCSLTLLSNFETCSHALDWELGTHGIRISFVHRGRRYGATYLPDVAIDQGWTKEETVESLMRKAGWEGASSAGSVTRRFLRSGSSSGGNPDRPWEGMSEFKTVRYQGLKASASYSEWQEWRKWVESSPDHLATLEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8F5</accession>
    <name>D4D8F5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000176">
        <property type="protein sequence ID" value="EFE41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022495.1">
        <property type="nucleotide sequence ID" value="XM_003022449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8F5"/>
    <dbReference type="GeneID" id="9581072"/>
    <dbReference type="KEGG" id="tve:TRV_03391"/>
    <dbReference type="HOGENOM" id="CLU_058463_1_0_1"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="275" mass="30259" checksum="4660BEF159649945" modified="2010-05-18" version="1">MTDAPSDKHSESDGDEEVFHDARFPPDEEADLLSQSHSYKADANTLFSASNYSEAITTYDRALAVCPNYLDYEVAVLKSNIAACHIQLEEWESAVDAATSSITFLDRLAPIALATTSQSSKDADTGSNKTADATSRVVELPDNTSQGQEDEVLRTLKEKDTHREDVLRIRGKSLMRRGKARMQLGGWANLQGAEEDYKSLLELGILPPQDTRAVKTALRELPAKINAAKDKEMAEMMGKLKDLGNGILKPFGLSTDNFKFVKDEKTGGYSMGFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8H8</accession>
    <name>D4D8H8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022464.1">
        <property type="nucleotide sequence ID" value="XM_003022418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8H8"/>
    <dbReference type="GeneID" id="9581011"/>
    <dbReference type="KEGG" id="tve:TRV_03414"/>
    <dbReference type="HOGENOM" id="CLU_064620_1_4_1"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="147" mass="16778" checksum="15920BC87CB5BC19" modified="2010-05-18" version="1">MKRKFLASYNPDSTDYAALPAYGCAAFNNDLRGLLHTFNTTPPSDSLASARREIDNVRDIMTENIERVLERGERIDTLIDKTDRLGSSARDFRVRSRDLRRRMWWKNTKVMVLLIVVVLFLIYLFVGMGCGLPAWGSCVGHGARHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8U5</accession>
    <name>D4D8U5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022322.1">
        <property type="nucleotide sequence ID" value="XM_003022276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8U5"/>
    <dbReference type="GeneID" id="9580869"/>
    <dbReference type="KEGG" id="tve:TRV_03533"/>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="187"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="39269" checksum="6DD399931A7954B9" modified="2010-05-18" version="1">MIFNGTTANICRLGSLLMDLDALAGVVSYRHAGDDVALVTAAVDRITIENPLKEICDLELSGQVTYSTGRSSMEVSLQVAKAPAEGEVVRAEDVLITCAFTMVALDPKTKNIRPASVAPLLVETAEERRLFEKGEHNYNAKKDLRQRSLKTQTPNDEESDLIHAMWTKRAGREIPPELSGVSATNMKDTRLSAAQIMQPYDRNRHNFMIFGGYLLKQTFELAYCCAASFSRSRPTFLCLEPSTFDNPVPVGCVSYLNAVVSYTQDSPSTSSTGQKFTRVQVRVDTTARNIDHGTSNPTGTFNYTFLVEGQHEVWPQTYDEFMIWVEARRNVENMNASLPSPDNVAITYKEGATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D951</accession>
    <name>D4D951_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin-specific chaperone c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022238.1">
        <property type="nucleotide sequence ID" value="XM_003022192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D951"/>
    <dbReference type="GeneID" id="9576840"/>
    <dbReference type="KEGG" id="tve:TRV_03641"/>
    <dbReference type="HOGENOM" id="CLU_032612_1_0_1"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="207"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="407" mass="45051" checksum="0249A1376615AFF2" modified="2010-05-18" version="1">MLSKDTEEECLVQDAGGDAADHQQAQSTNDKFFRYFQEEVTKVEERITKLHTTPAAGGEQASAADYCLADISRLSDEVKDASTYIPSYDQRAYASAIKALQEKFADAKEAIAPRKRFAFKRSRQPTPVQNTTDEVMQDTPETPQTTALNPSPEPTTRVALVSHEKVTDNMEPKPLTAVDEGKKETQQGEQTVKEQEQQQEEKEQLQPQRSESQLPAAQVISFSDIENSHATLPGSAPLRNASLSVSSVQKSVIDMSSIPELGRSFSTCIFRDSCDSLAIFGKVDGPAFISDVIDSVVVVTCHQFRMHDCNNVVVYLSCTTNPIIEGCVDIKFSPLPEAFSAQNGKQADKWSLVEDFNWLKPEPSPNWSVLEDEDTVEDHVWGRILGDKRGMKLTEILEKTGVTSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D969</accession>
    <name>D4D969_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022256.1">
        <property type="nucleotide sequence ID" value="XM_003022210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D969"/>
    <dbReference type="GeneID" id="9576858"/>
    <dbReference type="KEGG" id="tve:TRV_03659"/>
    <dbReference type="HOGENOM" id="CLU_2063184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="119" mass="14376" checksum="C42BEE69ACED89C1" modified="2010-05-18" version="1">MLMLISEEEKKKKELELFESRRKAKGEKKKLKRKKKSERRRELRRRERERETDREKGREERKEEKGNRPQEQVPVYAAEEEEEEEKKKKKKKKTEDGEMARSKVPHRAEQKAGGTKAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D987</accession>
    <name>D4D987_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000188">
        <property type="protein sequence ID" value="EFE41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022197.1">
        <property type="nucleotide sequence ID" value="XM_003022151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D987"/>
    <dbReference type="GeneID" id="9579082"/>
    <dbReference type="KEGG" id="tve:TRV_03678"/>
    <dbReference type="HOGENOM" id="CLU_1769437_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="147" mass="16257" checksum="4A024200C3A71D87" modified="2010-05-18" version="1">MASDLPDQNRQPKNEEAQGAHPVDQALPRRATLPPILTATPPCLPVYLYLTARVFVRLARLSLLCLAACFMRADYASPFSLSCPRKLQPTKKVNVTFSGFLQKGKTTSSNSFFTLALLSLLLFRETSSSIFFTLVRVHSPGRLLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9A2</accession>
    <name>D4D9A2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022169.1">
        <property type="nucleotide sequence ID" value="XM_003022123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9A2"/>
    <dbReference type="GeneID" id="9579063"/>
    <dbReference type="KEGG" id="tve:TRV_03693"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="140"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="316" mass="34215" checksum="11B6CFAB2C1C0423" modified="2010-05-18" version="1">MTLHEQDDRSTDADKDTEIVGTAIRVGPKVTLIKEGQRVGVGAQVFSCGTCKQCKNDNETYCPNVIMDTYGSKWPDTGIVSQGGYGSHVRVHEHWVFPIPEKLATTSVAPMLCAGITAYSPLVRNGCGPGKKVGIVGLGGIGHFGVMFAKALGAETWAISRTRAKEADARKLGADGFIATAEEGWEKPHKFSFDLIINCANSSKNFALDKYLSLLDVHAKWVSVGLPEEDGPSIKAQSFIANGVLMGASHLGSRREMLEMLQLAADKGLQSWVEEVQIGEDGLRDAVTRMKKGDVRYRFTLTGYDAAFPKPPRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B6</accession>
    <name>D4D9B6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022183.1">
        <property type="nucleotide sequence ID" value="XM_003022137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B6"/>
    <dbReference type="GeneID" id="9579054"/>
    <dbReference type="KEGG" id="tve:TRV_03707"/>
    <dbReference type="HOGENOM" id="CLU_036632_2_0_1"/>
    <dbReference type="OrthoDB" id="4172832at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055366" description="Rhodopsin domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="30970" checksum="AB98BFF5441AA34B" modified="2010-05-18" version="1">MCRILLGVLALWGLAGVLSLSLQCGLAQPWKSGENCWLNQYALHVGLNIGSMITDFALVLLPFLFVSQVQIPCIKKLAIAALFGMRLIVPSFTIVMTITSRSYFASSASERSWLAVMPTIWMQAILCISIVATCIPNLKRLLAVLRTGLMAGTVNEFYELSVSGGDSKTVASASQLRSGKTSYSKENYGTGTPRPSTSGGSVSGTPTMSSFTGKAHAMRHLHPDTAYTMGKKEPYDNAYVVESKIPSCKRPILKLQGLLWERSLRPGTTRAKVTDRGSSLDVLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S7</accession>
    <name>D4D9S7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial mRNA processing protein PET127</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022009.1">
        <property type="nucleotide sequence ID" value="XM_003021963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9S7"/>
    <dbReference type="GeneID" id="9578893"/>
    <dbReference type="KEGG" id="tve:TRV_03870"/>
    <dbReference type="HOGENOM" id="CLU_003477_0_2_1"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="57776" checksum="3C7911E7A1C65862" modified="2010-05-18" version="1">MVYNFDPYLRDIMPVSEFDFKALNDYITSSKDTVLKDKAIAAGKKYIGSSSSMTGVLSHFHFLLSEWRELNTSHLSNSFPATSKTYTKLSRLPAVVFLRYRDGVYAVDADKEWDTSNVLMGLGKSMEKLLTIPRDQYERYRRNSPDKILKEDSPPEVYHYSTCGDFLMRSQLDAYDPRLPGTGMFDLKTRAVVSIRMDAREPWNAMGYQIKTRLGDFESFEREYYDMMRSAFLKYHLQVRIGRMDGIFVAFHNIKRIFGFQYISLPEMDKCIHGQEDTALGDAEFKLSLNIWNKVIDVATEAFPKQSLRFHFDTRETQNPFMYIFAEPMTEDEITKIQERNLDEIQAYEKRVFYPELLESQQLDSSISEADNPTKQEPESKESASEDDIDPEKPLLAMALSIRNFVNGKEVDRPTMFTAKDTWTVKYQLAHFGKERGWTLYNACKKRRSRFLGALEDEEAPNSAFKERLNAISKEGQKWRDEMDKIEKAKGIIQYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA00</accession>
    <name>D4DA00_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin conjugating enzyme (UbcM), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021914.1">
        <property type="nucleotide sequence ID" value="XM_003021868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA00"/>
    <dbReference type="GeneID" id="9578797"/>
    <dbReference type="KEGG" id="tve:TRV_03944"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_4_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="101" mass="11322" checksum="E0063D4ADF943F08" modified="2010-05-18" version="1">MGPEGSPYAGGVFFLAIHFPTDYPFKPPKVNFTTPVYHPNINSNGSICLDILRDQWSPALTISKDPNPDDPLVPEIAHLYKKKDGEYERIAAEWTRKHAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAD0</accession>
    <name>D4DAD0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000207">
        <property type="protein sequence ID" value="EFE41191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021809.1">
        <property type="nucleotide sequence ID" value="XM_003021763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAD0"/>
    <dbReference type="GeneID" id="9578687"/>
    <dbReference type="KEGG" id="tve:TRV_04077"/>
    <dbReference type="HOGENOM" id="CLU_101051_0_0_1"/>
    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="166" mass="17577" checksum="A4B3A8AED6694A46" modified="2010-05-18" version="1">MPAYRMLDLNPLSAQENTMYSGRGGAGNFHPLKNSAITPSSSISSTRTLSSRLGFNARQLLPGGRGGLGNFHSSSEYAIFSFDEELEQQLKREKDVAPVFHIGRGGAGNMAAAAVPDAPIMNLSKKRCGTGSVGSSSDGSSSSGKVKDWPRRNLDSWRGALKGMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAD5</accession>
    <name>D4DAD5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021751.1">
        <property type="nucleotide sequence ID" value="XM_003021705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAD5"/>
    <dbReference type="GeneID" id="9578686"/>
    <dbReference type="KEGG" id="tve:TRV_04082"/>
    <dbReference type="HOGENOM" id="CLU_017393_0_0_1"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="522" mass="57951" checksum="C06FE03F86B6E90E" modified="2010-05-18" version="1">MNNEQFRRLLFDNRTGSSSPADITAKKASSSDNAAAKGRSGALGSRMRSSIPMTPRDSQDQPPSKKFKSSSGPKGFKYAPGYEDRASLRQRNDGKEADDREERVCGLEELLKLGQIDQPTFDKLRAEIGVGGDISSTHLIKGLDWQLLKRVKAGEDITSKSQDPTPEIPNDDDEFERILEEKEKDKVESVEIRGKEKKKGNLAPLAQVGSKKMTRDEILKHLKASRLAQSTQPEPSLGSKFKKIGSTETKKKRWVETDASGRRKEILVITDADGKTKRKVRWLDKQDGANAHLLSVDKNAKPLGMDVPAEVLARMKPTDALEAEDDEDIFAGVGDDYNPLVNAAEDESTSSEEESDKRDASTPKEHPSGSAVGTHDEHKPSSTLRRDYFATGKAKREPEPSEQESTDRSNPLMSDPTIREALRKAATIRTREPISDDDTNDVDKRSAEKHKSFLEEAKRREMEDALDMDMGFGDSRFGDDDEEEFLPQGSSQNKRKRGPKKKKGDKNNVSDVLSVLQGRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAI4</accession>
    <name>D4DAI4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Checkpoint protein kinase (SldA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021800.1">
        <property type="nucleotide sequence ID" value="XM_003021754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAI4"/>
    <dbReference type="GeneID" id="9578680"/>
    <dbReference type="KEGG" id="tve:TRV_04131"/>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="834"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139411" checksum="ECFF83FC1741DC28" modified="2010-05-18" version="1">MARPSDDRIDFDLIENQKENIQSLPSGRSAKALAAVFSPRPLDQSSRSSELDETRTLNDAVRREYEAELESIAESDDPLDIYDRYVKWTLDAYPSAQATSQSGLLPLLERATNAFLSSTHYKNDPRYLRLWLHYIQLFSDSPRETFAFLARHGVGAQLALFYEEFASWLERDGRIAQAEEVYKMGIEKEARPTERLFRKFGEFQKRAEQRPSGSDGPSSPALPRVRPALAAKFDPFASSAASQDPQAEPTRSGLGGGTSTSRSRSGKPKMAIFSDADGGAEATKSSCSPGTRGWDNIGSLKDRRKENTIEPTPWAGQTLKAGKKPAATQKMTVFKDESMQTINVSRNNKERVDPRTGKIERVVVNLEAIYPDPHNPAVEMSLDELRAIRRGWMSKDWDKQRKKPLREIPQNEVTGRDPHINGNDYGPDKHLSMAMQEKLQIYDEAGRDPKLAKGKKTKVKEIKMETQIVKTNLDSPTGPRIKKRGSTEPTMTFHTKEATDEIYGIFNQPLKSELQLAKDLDSVYGSDYEDDDCASIGESTTTGAISAPGSDFEDDKTNTFKASRAIIGADGLGDRTEEDITSASAWTEFSPEEHVPGPGTITPREEEDAESSDGLGTMPTPRRGDRIVHQEENFVLVPPEDYNPPRGPYRDAFVAAQNRLPFMTPIVEHTETSLASTMFKNKHYMSSKTPSKNSKPLFSASTPAIPEIDDLMLASQDDAEFDMLGDESPSKMAGKLKSPQSMFKRGGLVEPRVLIEDVQCNPIETAIRDKILKGLQPPLRVYPGYNDHTSQIGGNGAEIKKYLKALAKPPKAHGSEKQFTIPPIICLSGAARSYAVKRELGEGGFAPVYLAESIDSPDTFSDSEQENFPPAKSSHLTGGNGAVLRDLERKPLEALKVESDPPSPWEFYMLVTARTRIENSSYYRRAKDSIVQCHEIHMFKDESILVEDYLNQGTLLDLINIKTESTGPVAPSDQCLEEVVIMFFAAELFRTVEALHSCGILHGDLKPDNCLVRLPGPASASTIPTPRSGSLLADDEGCRPEDGSTGYSPSGLYGWKERGLTLIDFGRAIDMRVFKPEVQFIADWKVGQHECVEMRECRPWTYQADLYGLAGTIYVMLFGKYMEVSQVTERTSDRPGSPSLGNERGVGAQKTYRIKESLKRYWEREIWSDVFDLLLNPLSPKWVEIERNAREKASPGSADGDKQPTFPVVHSMRLVRENMEAWLVANAGRKGLLGHLNNLENLIARKRGKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB07</accession>
    <name>D4DB07_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021564.1">
        <property type="nucleotide sequence ID" value="XM_003021518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB07"/>
    <dbReference type="GeneID" id="9578524"/>
    <dbReference type="KEGG" id="tve:TRV_04306"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_2_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="328" mass="36049" checksum="EF41184E77D00E35" modified="2010-05-18" version="1">MVWERVFACIGILTTVCIVVNLLSVAYKFLRPSKLHKYLHDGKQTYAFVTGATDGVGRSMAYELAKSGFNLILHGRNSEKLQAITDDLQNQYPTIKTRKFVCDASKDLLDSSTLSSLHKVLKDVHILILINNVGGMGCLPPSCLYQAYESYTGEQIDVVLNVNLRFMVQLTRILIPLLDHSTSMTAASNKRLPSLILNMGSVGAHGSPYISVYAGTKAFVASFSNSLSMEMKIEGKDINVQALIIGETRSATHIVKDGMMVPHSNSLARSALKMVGSDRETFVSGCFPHWMAKIFVQVMPVYVSNALFADAIKKLKAAHEKRVASLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB36</accession>
    <name>D4DB36_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021488.1">
        <property type="nucleotide sequence ID" value="XM_003021442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB36"/>
    <dbReference type="GeneID" id="9578469"/>
    <dbReference type="KEGG" id="tve:TRV_04335"/>
    <dbReference type="HOGENOM" id="CLU_349148_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="801" mass="91814" checksum="FFE652BF507A5857" modified="2010-05-18" version="1">MSPLGGGKAGLRSQLFGILSAAAHADSVRIPSNTSIARKQFASLSPSARYATSLRSTYDEPDSGLPPPEPTVNRGLRDSESSSRRKGLARRRKSEETGRHEQNEQPQHRRIDIPQRKQTPTSRMNEKSKLTHRLAPPISAPLRYLKGYNLSQPKRRQLRGKLESECAGIQSYGDHAVHPSEYLVREMSLYPLTHIHPSWKKNLKTLYDHKRRNVSVSETWRLLSTEDSEVVRRWIKSILSSPRTEPPPSTRWRRLCRTEAARRWPIMILWLLLHSPARALRFLEVTTTRFSPSFPMVADCFIFLERFHVAEFQDSPKLKSRYTRALQHCLRPEVLPYLSRDSQTGFRLYLKYCEHHNLVKCFNYVLKNQKFLSLETLFYFTDLFTKNGDISAALTSLHLLIMRFESQKPVRYQKISDRCCNLLKLDRYTRQDDGTVSFDILPRILEMGVQPDLSIFNIVVSNALRADDLDTALQIVQLMENQGVTPDSYTHLSVLHHAVRLRDHEKVDHVLSKIAKVDSLSTQPHLVSKTLHAMLLFPHNSSPGQTGSMESFHKMLDVYKKSHQIQPLVDLGLVPRSQNDELLSASKSPPSSQALNIMITAHLRTRPQADKIWRYFTRFQALVASGHPMITPLISTDYVFNSFLMALRFEPQMIYKCFKILNYMLQPLPEVAIQTMKAHHGGPVPLRPAQPSQRTWTILLNTLISHNQMQAAESLYKTMKERGVEINDVAWNILIRGYACNQMVEAAANALKEMERQSWSPDGHTVKALGFIENQELLRTLLDRLDASEPESENSKLVTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB72</accession>
    <name>D4DB72_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="11" type="ORF">TRV_04371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021524.1">
        <property type="nucleotide sequence ID" value="XM_003021478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB72"/>
    <dbReference type="GeneID" id="9578485"/>
    <dbReference type="KEGG" id="tve:TRV_04371"/>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="319" mass="36212" checksum="5F53CC2850A79037" modified="2010-05-18" version="1">MAAPDQRKQQRAEPRKPLEGKLDENGQIMLPKKKLYRQRAHANPFSDHQLDYPDHMDWSKMFPAYVDPDPTAVNISGARKLVKNVEIADIGCGFGGLLVALAPLMPDTLMVGMEIRSSVLEYVTERIRALRSRHPPPAAPDATMDAASEPENALGEVSLPSTQPNVPEQPNFQNISAVRSNTMKFLPNFFFRHQLSKIFICFPDPHFKARKHKARIVSTTLNAEYAYVLRPGGMLYTITDVEDLHLWMVSHFDAKPADNDLNSHDIAELWERVSDEELAADDCVRVMREETEEGKKVTRNNGQKFVAVWRRKAEPEWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBF4</accession>
    <name>D4DBF4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000225">
        <property type="protein sequence ID" value="EFE40820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021438.1">
        <property type="nucleotide sequence ID" value="XM_003021392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBF4"/>
    <dbReference type="GeneID" id="9578398"/>
    <dbReference type="KEGG" id="tve:TRV_04454"/>
    <dbReference type="HOGENOM" id="CLU_1375212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="199" mass="21919" checksum="4816120463D808EB" modified="2010-05-18" version="1" fragment="single">NHLAAQPTGLEKKKERKKERKKEKEEDDGREREPVYVYGVAITYQVKGPAVLTSRFMLAVRLRPSKREVDCQLDSIANMQAERRKGTTNCDRRDITTSSPSSLGVWTEGLTPLAACDAGVNHPMRRRGFSLFALALSRFTSHFCPAAAALFQLYRRMSSDMLAIKLGDQTSPNPTRAPSPFIGNTSNACVSSDGADLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH7</accession>
    <name>D4DBH7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021403.1">
        <property type="nucleotide sequence ID" value="XM_003021357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH7"/>
    <dbReference type="GeneID" id="9578282"/>
    <dbReference type="KEGG" id="tve:TRV_04477"/>
    <dbReference type="HOGENOM" id="CLU_2251944_0_0_1"/>
    <dbReference type="OrthoDB" id="4173475at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="101" mass="11202" checksum="92E570FF2827A10A" modified="2010-05-18" version="1">MEKHHIDIDLKMFPVAEEEHMLAFTANGVKIGMIRSADYSIEINDVPVERMDRLGEINTTSPIMTTLSVIGVLVLTALVGLAVQIANLYVFRVMVCNAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS3</accession>
    <name>D4DBS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000230">
        <property type="protein sequence ID" value="EFE40694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021312.1">
        <property type="nucleotide sequence ID" value="XM_003021266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS3"/>
    <dbReference type="GeneID" id="9578163"/>
    <dbReference type="KEGG" id="tve:TRV_04574"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="552" mass="58962" checksum="21E097ED018CDC8C" modified="2010-05-18" version="1" fragment="single">MKEDEKPPVEDVKKESSEVSSQQAATEKMVDEKKPDGQGEDEGGYTSGARLVVIMVAVLMSLFLVALDRTIIATAVPEIANQFHALTDINWYASAYLITSCATQLTWGKVYTFYSTKFVLLSAIVIFEVGSALCGAAPNSTAFIVGRAIAGTGSAGIFSGTTVVIAQVVPLRKRPVYVGMMGSIFGIASIIGPLMGGAFTDRVTWRWCFYINLPIGGVTMAVLLFLLNVRSKKESTPWKAQINRLDPIGSILFLPSATCFLLALQLGGTSYPWNNGRIIALFVVSGVLMIAFVAVQIWRQEDATVPPRIFSQRSIASGTAFSAFVGGVLISMLYALPIWFQAVKGTTAVQSGIDTIPMVLSLVVGSILSGSIITATGHYVPWMYVSTVLMSIGAGLTTTFKPDTNHSAWIGYQVLFGFGIGTGLQQASLAAQTVLNMKDLSTGVSLMFFAQSLGGALFVAISQSLFSNALASNLAKVPGLDVKAVLASGAKDLSKVVPLDKLPLVLPLYNDSLRRSFIVSLAVSCLMILPTIGMEYRVIKKKEKTPAPEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBX9</accession>
    <name>D4DBX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021199.1">
        <property type="nucleotide sequence ID" value="XM_003021153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBX9"/>
    <dbReference type="GeneID" id="9578043"/>
    <dbReference type="KEGG" id="tve:TRV_04630"/>
    <dbReference type="HOGENOM" id="CLU_014183_2_1_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="376"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="75107" checksum="A8C171B60BC2772D" modified="2010-05-18" version="1">MSDLPIQQTNVPLVGDQDAENSSTAGDKGLKLIVVGDSMTQGHEGDWTWRYRIWQWFREQNVTITFVGPYTGTVQPDRPKPPSPPPLYGSPKPRQGVKVDGGYARGVSADFDSHHFAVWGRTAALDKDLIEDVLMAHPADLMLLMLGFNDLGWLQSDALGTLRSIKTLVDNARRVNPFLKLAIANVPQRLMIGGREDLPCSTREYNNLLRCAIPQWSTADSPIHLVEVCEDYGCGPDGCPAGYDGLHPNATGEYEIARAFSLTLVRDFNIGSAPLVIPKNVPKRSLPRPKNFRVVSSPGGVTASWDAIYGAMSYDVRSRISGITEFHTSSVSSNRWDSQWTQEGWVYEVQVRASAGNALKGRWTAIKSAKSTPKTPPGPDNVIVNATTTGFDISWDSCPSGFNVTEYEILYWDKDKKHTFITSAGFKESPAHVDDLIPGHHYQLAIVSWNGAGGGFPKGVRSVTVGRGTPPIPTDLKITAKDATSAHLTWTGSPAAAGYQLWFRNVNEPDSELCRVNGTESKPSSDQYFLVPGVWNFEWCVSAFNGSAESDRCESVLAPRPSDASISSSDCSEEDTNSRHESAKDKDINGSLTPEHKHMPCTPTTQCETPLQEEDQGWGVLCGTCGHTEQDDIDCLGSGGSKQLHGDRCYRDECKHADCTNPECWIYVCDNSHAEKDDTVTKCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC48</accession>
    <name>D4DC48_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021183.1">
        <property type="nucleotide sequence ID" value="XM_003021137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC48"/>
    <dbReference type="GeneID" id="9578027"/>
    <dbReference type="KEGG" id="tve:TRV_04700"/>
    <dbReference type="HOGENOM" id="CLU_102308_0_0_1"/>
    <dbReference type="OrthoDB" id="10314135at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="237" mass="27099" checksum="CB377344CFC6E9B6" modified="2010-05-18" version="1">MEQWLKSEQVKSYINACHQRQENHAFEKARCKEYFAELFYQDAQKGLMECPPALWVLAIFCRFLFASLRKPALDLMESGGHWNWPYWLGELFCCGGMVLQLAIAKNPQLSTTKARVTILVSTFVSHTMDAIAACYLGSRENDAFLNGVAYVSRIGCEFFIMIIGCWATLHTIQPQEVDQAGCLETWDQLPAEYKYWAESSLSNYRDEQNCQGTLRRSSRQRVQAKARASPVDNTKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC74</accession>
    <name>D4DC74_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000238">
        <property type="protein sequence ID" value="EFE40543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021161.1">
        <property type="nucleotide sequence ID" value="XM_003021115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC74"/>
    <dbReference type="GeneID" id="9578011"/>
    <dbReference type="KEGG" id="tve:TRV_04726"/>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="595" mass="63427" checksum="1AFF21A1E7592E56" modified="2010-05-18" version="1">MDTGGLAQMTYNNMSLNTSSLGVPGSGFASRGKGSHIKRLSVPHPSKLDQRDDAHGSISTPRTSRSHLLAGLRTAPKQPTTPSTAPLMQEHPHQNGFGGMQNYAGHPNAYLGGVPQTATGVSFNHSKSYSSGNAAQTYGQMYSLPEHVLAPPALDHILEENGEPMDEALYAELVSTNLYLAAQQQRLQQQLASVTAAAQQFQALHIGTPMHSTHAQALQQQQQQLFSPLPTMGFYQQQAQHGMQPVVHPVPGKPGVFSVYNPMTGQQSYVVDNSVYDEVPLSAAPTTSTYEDQIRSPVESHTSNGGFHAHTNGNSNGHTNGNTPSMFRTSARVSPPPTESRQSPVRNHSSTPSTRNPTPPREAQSQVQPQQQARQSPPLQSPAPGIKRDHKKSLSLAVKLINETTRSGNNGASTPKSAMFPQTPASAGPGTFGPGQNRAGEHAIRQPRGPPPLEELVAKPTTKHEGSKNFATRQRRRAVHSLVRARLERNTSTSTSNGNSHSTGSVTPSSEHGNEHEGEGEFSFSPSDGDADSSSSLSGRRSLGSLRAAANGAIGSERKQVTGATNNGAGELDAGRRKMPIMVLSNAEKRKSTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC77</accession>
    <name>D4DC77_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04729</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000238">
        <property type="protein sequence ID" value="EFE40546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021164.1">
        <property type="nucleotide sequence ID" value="XM_003021118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC77"/>
    <dbReference type="GeneID" id="9578007"/>
    <dbReference type="KEGG" id="tve:TRV_04729"/>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="233"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121964" checksum="84AE3DAAB055FA5E" modified="2010-05-18" version="1">MVRLPLPHRRSGNRSPKIGAASSQDDLSASSTGTSETKYPLILKTQVISGRNLAAKDRNGMSDPYLVVTLGHARESTPTISKTLNPEWNVCFDLPIVGVPLLECVCWDKDRFGKDYMGEFDIALEDIFSNGQVQQEPQWYDLQSKWKTSSKKNNDVSGQIQLQFSLVDPSNPSAPPDQILSKFKNLIRNSDDEEEDATPTTSGDNEEVGESSREDLTRPDAIAQQRQKSKVARLKRRSIAVRAYEFCGAKDGVVGIVFIEINKVLDLPPEKNMTRTSFDMDPFVVTSLGKKTMRTRVIRHNLNPVFDEKMVFQVMKHEQAYSINFTVIDRDKLSGNDFVASTNFPLQTLIQAGPEADPETGLYELLDLPQDPVEPTTPQSSSKSRFRLTLSRSTSASNLAKMAKPSLKSKSSAASLASQYQQENQQPAPTSNPTASQADSAATLHVPGSISPPSPDKTGFPSTNPDTEAFKHYVIPLTLKNKDRWEDKHNPELHIKAKYMPYPALRQQFWRVMLRQYDADESGRISKIELTTMLDTLGSTLKDSTIDGFFHRFAAENESTGDTMDLTFDQAVICLEEKLQELQKKTVGATMSKLVQFPSSSSGPLESEILPDGEDEEDEDDNGLLTPAGGGGTRLTLNPAHTNLELPTVSTTTSRDESISGSDEGINSPQGDLTDERGEEHVIEIRECPLCHQPRLGKRSDADIITHLATCASQDWRQVDNLVMGGFVTSSQAQRKWYSKVITKLSYGGYKIGANSANILVQDRLTGQINEEKMSVYVRLGIRLLYKGLKSREMEKKRSSSASFYLPPHILTHKYNQPLTQLTCFSVRKMLKSLSIKQGRKYDDPASSSQIEAFIEFHQLDMSEVLLPLDQFKSFNEFFYRALKPGARPCSAPDDPNIIVSPADCRSVVFDRITEATQIWVKGREFSIERLLGKAYPEDVERYKNGALGIFRLAPQDYHRFHIPVDGTLGTPKTIEGEYYTVNPMAIRSALDVYGENVRIIVPIDSVAHGRVMVICVGAMMVGSTVITQEAGAKVSRTDELGYFKFGGSTLLVLFEPGRMNFDTDLVDNSKGALETLVCWRALLYLFLSPPPPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCD2</accession>
    <name>D4DCD2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021112.1">
        <property type="nucleotide sequence ID" value="XM_003021066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCD2"/>
    <dbReference type="GeneID" id="9577954"/>
    <dbReference type="KEGG" id="tve:TRV_04785"/>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="98881" checksum="D1610780859A443F" modified="2010-05-18" version="1">MKPASSPKRPQDHPPLPPLPTERPSRPVDLQARRSSSSGSSAASSTASNQTALNVSKGTLYGLAQQQQQQQQQPHDQQLPQAVRPPVMAAGSVNGSNTSLALRPQNEPVQRRASPLAQGPSASSSSDTRGFRSRHHSQGFFEPSLPTASHSSSAAVSASRIAAQTAMQHQTDQHQQYHHIRNRSQTIPPPQESGLAARRGARDSPPPIQTNNLRPPLPVPGQLGFQSSPGGGRAAGAATTAANVAFPRTPTPQNALPSATGNTTTTISGGAADRAEPGGQKEKQKSEKSKMKLFSKPKHIGMSRDKEDKKEKTMPSPSKLASRLVNASTVSLNDPTGGVAGAGAGAGAGGDININNSNNGLSANNLSLYSLANSSATTVVPIERHSLDEDRGKEKEKHRHHFLSRQKLKLKDKEDFHLPLSSASSNSRPLDPSAPQSLYSFAPSSPAASTFGKSMSGLDLRHGGRALREKKKEEKASAAAAAAAAAQAQAQQDAMMREGTDHPADWSGAASVTGSTVTFGGPSSSVGSTQGAGIMPGSNAAIQEILQGFGLQNMTPDDAWDFLKAKLLVLFEGEDVRIALEDLNKLVRVHIHCCVQKHAPHQVVEDLRDLLQTGFASLNYSLAKVPEENIIPHLVNVWVFAFGNVLPFIQATFLPLDLEFKGHGSIMNTREAREFWGAQPGASDASTSAGDALDVRKIVLTSFRDNVILTRYDVLKAAFSRLSLEKMNANINGPPTATLHSSTTASASRPSTAAGYETSFGGGSYASQPSSSHLNAGSFSSESAIASLTRARAISNTSSNPEHTYPSSYSSFSPSQPSILAQTHSHSTNIPAPPQPPPTDPSHVTETAGRMLQCICVLASVQSDDDAQQKIEELSKALKHNWLGRGRTGRNRRGFVGTKIRPPPPPRKDTSEEQANYQSTDETPRGTDATGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE3</accession>
    <name>D4DCE3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021083.1">
        <property type="nucleotide sequence ID" value="XM_003021037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE3"/>
    <dbReference type="GeneID" id="9576735"/>
    <dbReference type="KEGG" id="tve:TRV_04796"/>
    <dbReference type="HOGENOM" id="CLU_2706590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="73" mass="8166" checksum="AAA4C3872470E4EF" modified="2010-05-18" version="1">MAKNHEELDQYGSMSLDPPASPQYYEGGRGSEGIEERDSIMEESDSDTIGRSALEVRILLHVYRPVLQQPNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCK0</accession>
    <name>D4DCK0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Telomerase activating protein Est1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020990.1">
        <property type="nucleotide sequence ID" value="XM_003020944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCK0"/>
    <dbReference type="GeneID" id="9577842"/>
    <dbReference type="KEGG" id="tve:TRV_04855"/>
    <dbReference type="HOGENOM" id="CLU_013363_1_0_1"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="232"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="89352" checksum="EFA15F710C6F9704" modified="2010-05-18" version="1">MATSVIHNGAGHLNAEETFERCKAALTCALKEKEPTFAEVERLLAETRVTGQVSIFQIFTEGRRGSRHYHNDGGAVGRPDGVDIRNPMDAVKLEGGLWDAHLEINGRFRKWLSNIQEDEKKGKKRPVEKRKLINRYSKFIKSSQEFYEKYIHHLLEDFKAYNFPQFEEVARRKGYVFEKEVEGPRDSAGTLDPQLKHAVLSSCHATLIRLGDLGRYYQTELVDQQKKNWERATKNYSMASLVNPNSGNPFNQFAVIALAEEQHLDAVYYLYRAISAQEPHPNAYKNLTKEFKNILAGKKKAQPSTSISDPQAVLVSSFLFLHAECYQGDSPEHEERENEIMHQVTVDLKENVLERSLLEKFALINIASESHAKDTNAQVFLRRLNVIFFFTLLQVFLAELECSADKVTSVAYSILPALRHYSSWLLVNSPVLVSAPESKDTPLCIQIKELWKSYANTLTVLTSTFDVINLPDVDYLLEEDENTLGFKPFAHPNTMRRYGPPGATKPRRHETTASNDKEMLFRIRQFVIDGLDLERNERIPIVMVNKEDARLFVYKEEGLPQFLNSRSQTRGHGHTLTSTSIDLDEIQKPAPSSSALEDGASISGSASMHRMVDNLVESEPAESLVDGDNAPSYYASVNSNHRRSLAHQGLENGVSGAQGPSHFQSYSPGPPLPSIMNTAFAPQPGEAMSPTSRPSTAIPSTAGGNNSTLFSSSFLSCFVDESPSSLPYMQTPRLGHATSYAGGTSLGVQPSESITAFGQYQPHQPYNSPSYFNNMPYGTNRGSMLHYAGVIGEQSPPSGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCR4</accession>
    <name>D4DCR4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000249">
        <property type="protein sequence ID" value="EFE40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020973.1">
        <property type="nucleotide sequence ID" value="XM_003020927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCR4"/>
    <dbReference type="GeneID" id="9577829"/>
    <dbReference type="KEGG" id="tve:TRV_04919"/>
    <dbReference type="HOGENOM" id="CLU_418081_0_0_1"/>
    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="656" mass="70396" checksum="E09886CD62D29AD2" modified="2010-05-18" version="1">MAAAGAKGARSERRNGGTAQASGRWDGGGRRRRRCSSSSSQKAREPESQRARRESKVLMLFFFCFCFCFFLHLSLSPCSLQTLSHCLAGLSQQGSLLAVSRVKSCPAVSDFGLVYSRIAREPAQKKKKGTPVQRGSFLALRHSSRRPSPSPPAAAKKEKKQQQRTKRRRSRRRKRKALPGRPCLSSPRPLPFPTPRFRGLPSLSSPGVGTTLDSLIGCARFSSAQFWGVVLAAGVSLSLTKHPCFSSISIILRPPPDSFTLAGCSLTNAPPVVTALVGGHGGLQGPREARRRQGEGGYSLQVHPAHEDRPQGASQSCRHGQEVSLPSSSFYLSIYLSTYLVMLIYTGCRPQLAARPRAAAPADADLTTDPATASPAPGQAQGQAQPPPAPRQWTSMQEERARALFAKYGLTLEPGEWITGPATGLTSSPAGPTSHPTTNGLTNNISASNNLNQVERVEKPIRMRVRRNCHRCLATFGADKVCVKCEHTRCKKCFRYPPSKSETASSEPKRERAQKKIVNVAAGAGTTNTAATTAATTANNNNNNTATPTPTATTGAATAAASAGGGTASAGGTRDRAREEGRKTCPEKIILTIPSRTGGQDLVRKPVRQRVRRTCHVCNTLFEGAATECLKCHHLRCKKCPRDPYVFASLQGLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCX1</accession>
    <name>D4DCX1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG box transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020901.1">
        <property type="nucleotide sequence ID" value="XM_003020855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCX1"/>
    <dbReference type="GeneID" id="9577722"/>
    <dbReference type="KEGG" id="tve:TRV_04977"/>
    <dbReference type="HOGENOM" id="CLU_010453_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="260"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="260"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="811" mass="90246" checksum="114441DC6A43A508" modified="2010-05-18" version="1">MHRTPAIVCKEKLAVRRKRQQRKLQGEERKSGCKSNKLNMTELFKKPRINKGNFSFPSSIPSLSSSFFFLPSSIFVVVAVLCHIHNYIMIPMNKNKKDENTFYESYLSRLLSCFPGPIQRIFKLPLCQTIDFSQSRPYIMTTRGEMVITQGVSSGFEVEENMSSPRALPMTGMEAISHAALSHYQDNISVLSTLPVVAQADTTRKSMEVDASVVKSEAALRECSTSPNSPKSDFAEESNVQFCLCGPEPKIPRPRNDMPSNFDLLAFILFRQHLQSSVVAENPGLPNPDISKIIGKIWKGLPLKEQEPWKKHADEEKARHLQKYPGYRYQPRRPGRKRRNTNTVGPTVKVDVSGTSICSRCGGKPMKPPSTPSTPFLPNFNDSIDNVQVHSSLPEEVQRTQGHRLKLENAPSPINATYEESWRPAPIQDENIPPQSPCIKRRRSEEREMYPSIRHHMGPDNPYLSRITTLPRPDLTQRINSPNYIWGSQSHYSSSVPGSPHDPSLVLPPLKIAASNHPHCLASLEEQPKAISFLDKINLLSKGSPPFMSCSTPMSGQAEGAVIAIEGCDSESVACVTKYLNNSLSCDDGGNVKIFKGPESGNSAASEDTRKAAGNFLETIFSWYKISGTIIEFLNDRILPVTTRSTPGESGSNSSLQSILPKTEDLSICSTERSASDETVFTPEPEEAVHTPTSSSCNNNSTFRVALVPHYQLATTESHAGSTPRNSSHDAIDHWERMAMQWGSCVGPDITVYIRDCDQIELSKYGTGNPVENRLNDVRTLVIRRLAGSTEGIDEKALRRVGFEVKEFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY6</accession>
    <name>D4DCY6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020916.1">
        <property type="nucleotide sequence ID" value="XM_003020870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY6"/>
    <dbReference type="GeneID" id="9577737"/>
    <dbReference type="KEGG" id="tve:TRV_04992"/>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="38389" checksum="DAE5FEE63E80D567" modified="2010-05-18" version="1">MPLNHPIYHKDETVLCFHHDILYEAKIIALRLSDPEDRKSPYEYRVHYKGWKHTWDDWVFQDRLRKATEDNKELAATLRREAEAASRKKSKKKKTTAASDPGSTLGSDDRQSSIPARGTKRGRDTEIEKEDEFNARPSIRIVIPDNLKALLVDDWEYVTKNNQLVPLPAKGPVSTILDHYFEEEKPKRASASDIDVLEEVVAGIREYFEKSLSKILLYQFERQQYQMISNKWESGAEGYVDKGPCEVYGAEHLAPSLPELIAQTGLSQQATQRLREELSKFSMWLSKHSDRYFSAKYDAPSKEYIDKAKGVNSQDAPGTATARLFEMDKQEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDA6</accession>
    <name>D4DDA6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000260">
        <property type="protein sequence ID" value="EFE40162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020780.1">
        <property type="nucleotide sequence ID" value="XM_003020734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDA6"/>
    <dbReference type="GeneID" id="9577531"/>
    <dbReference type="KEGG" id="tve:TRV_05114"/>
    <dbReference type="HOGENOM" id="CLU_108559_3_0_1"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14250" checksum="309B825798780C9E" modified="2010-05-18" version="1">MSLSLLYRLKSWVDTVKTSNSKELPPQSIDWYYVRAAAVARHIYMRKTVGVGSLRKVHGGRKNRGSAPSHHVDASGSVDRKIMQSLEKIGVLEQDEEKGGRRITQSGQRDLDRIARTTIKEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ2</accession>
    <name>D4DDZ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000280">
        <property type="protein sequence ID" value="EFE39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020547.1">
        <property type="nucleotide sequence ID" value="XM_003020501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ2"/>
    <dbReference type="GeneID" id="9577248"/>
    <dbReference type="KEGG" id="tve:TRV_05356"/>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="242"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1222" mass="135635" checksum="729BF1CBEF880A39" modified="2010-05-18" version="1">MADAEIESIKRLQAERNGKKGSKTFDMSNQRTDVSTKASLTESFDTTLYDRADADKYAGYNTSIAVDGEDEDMADDDGQNGHRLVGQYTATSDQMKEFATGKGVEEEDILLAREKTSRISERETDYQKRRFDRALSPTRADPFAADGQGNGETEGASYRDIMALRELEKEEERVKKLIKDKQASEGANGSVEHEATLKLEEAGGDKDNDESAAAPTRKRKKRWDVSSEETAKPNEPESSEVKPKRSRWDQTPAPGGQPEAPKRRSRWDQAPTLTAATPVGNQGLATPVPQASGPVTVPTFGSDISARNAPLSDEELDMMLPSEGYKILEPPPGYAPIRTPARKLMATPAPMQSASGIGGFMMQEPESARSMGKQLPTEIPGVGDLQFFKAEDMTYFGKLVDGADENSMSVEELKERKIMRLLLKVKNGTPPMRKTALRQLTDNARQFGAGPLFNQILPLLMEKSLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDQDYYARVEGREIISNLSKAAGLAHMISTMRPDIDHVDEYVRNTTARAFAVVASALGIPALLPFLRAVCRSKKSWQARHTGVKIVQQIPILMGCAILPHLQGLVDCIGDNLSDEQAKVRTVTSLAIAALAEAANPYGIESFQDILGPLWMGARKQRGKGLAGFLKAVGYIIPLMDEEGANYFTSQIMEIVLREFSSPDEEMKKVVLKVVSQCAGTDGVTAVYLKEHVLQDFFKSFWVRRMALDKRNYRQVVETTVDLGQKVGAGEILERIVNNLKDESEAYRKMTIETVEKVIASLGAADVGERLEERLIDGVLFAFQEQSVEDIVILNGFGTVVNALGSRCKPYLPQIVSTILWRLNNKSATVRQQAADLISRIAMVMKQCGEDALMGKLGTFLYEYLGEEYPEVLGSILGALRSIVTVVGINQMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELLDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLATLLNNLRVQERQSRVCTAVAIGIVAETCAPFTVLPALMNEYRVPELNVQNGVLKAMSFLFEYIGEMAKDYVYAVTPLLEDALIDRDQVHRQTAASVVKHIALGVVGLGCEDAMVHLLNLLYPNLFETSPHVIDRIIEAIEAIRMAVGTGIVMNYVWAGLFHPARKVRTPYWRLYNDAYVQGADSMIPYYPTIEEDGLGRCELGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE06</accession>
    <name>D4DE06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020541.1">
        <property type="nucleotide sequence ID" value="XM_003020495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE06"/>
    <dbReference type="GeneID" id="9577240"/>
    <dbReference type="KEGG" id="tve:TRV_05370"/>
    <dbReference type="HOGENOM" id="CLU_011271_1_0_1"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="684" mass="77795" checksum="7A10327C2518BA28" modified="2010-05-18" version="1">MPSQNDAAASTAALPMSNLEAFLKPSPVLYSGSVAAAKGYLDSLTQDLKQEQRGQKRKQRTPVPQVHQLHVNGFNHNQIWEQAKRILDSALTISSRDLDRFNERNTALYRPSKQKFPEDDESMSDDVEDDEEMEDGEDSEDNEEMLDLEDEEEVDFGEDYDDSLLEEGNEEVEEEEEEEEEEEEKEDRTFEGDESPRPDKKKKIDPHGLNDDFFSLEEFNKQSAFFENRDSRRPHTDADSDEEDIDWDADPLALPDIPDKRTVDKDENDEDEDDMDEDELDLDMEIPDANSEEGDEDEDGDMGLNDDPRNAKYEDFFDPPPNASKSKSKQKKQTQEDIDADIDRAMANVRRDLFDDDEMSGEDDAMDGEQSKNMSSHEKRRAQIADEIRRLEAANVAKKDWTLMGEAQSNARPINSLIEEDLDFERVGKPVPIITTEVSNDIESLIKRRIITKEFDDIIRRRPLAIGEQGGATKRKFELDETKPQHSLAELYEQDHLRATDPGFIDKGAEKLRKEHNEVIQLWEQISSQLDTLSNWHFKPKRPQVDLNVVSNVDTITMEDAQPTTRGESGIASGNMAPHEIYNPSETRMAGEIKLKSGVSLAKDELGKEAKLRHRRRREALKKRKRESQAAASKPDSASSQKKELVSNLKKGGVKVIGKGGKLTDVQGNKIQDTASKGRENLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE35</accession>
    <name>D4DE35_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020505.1">
        <property type="nucleotide sequence ID" value="XM_003020459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE35"/>
    <dbReference type="GeneID" id="9584253"/>
    <dbReference type="KEGG" id="tve:TRV_05399"/>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="34500" checksum="AD6067199F7565D9" modified="2010-05-18" version="1">MPTEAEAADTAKPTDGATTSHQEDKAEKQKNDLEHSSKKNSSETESENSIANKTEAEDAASKNQDRLQRFKALQARAKTAVKNNLKETAAEAHRLSVDPNALSSISRKHAFASHSLLKADIETAGEDFERKRAWDWTAEESEKWDRRMDKKQKHRDNVAFQDYRQDAHKNYKRQLRRMQPDLEAYENEKAAAVQRAAANGGLEIIEDENGDIVAIDKNGAFYSTADSTDFVENRPDRAAIDRLVADMQKAEETRLKKRRERGQGDDDADVTYINDKNKRFNQKLARFYNKLRKRDDDITKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE44</accession>
    <name>D4DE44_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020514.1">
        <property type="nucleotide sequence ID" value="XM_003020468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE44"/>
    <dbReference type="GeneID" id="9584240"/>
    <dbReference type="KEGG" id="tve:TRV_05408"/>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="492" mass="56315" checksum="8A92A0E8067C065A" modified="2010-05-18" version="1">MAKANSTMNPLIAVVGATGTGKSKLAVDLAIRVNGEIISADAMQMYKGLPITTNQIPIEERHGIPHHLIGCVDLDQDPWRIGVFKKESLKIIDEIRSRGKVPILVGGTHYYTQSVLFHEPLLDEGEGNPNSQMFKPSEGPPNNEISKAEREECVDFSILNASPEEVYEKLKEVDPVMANRWHPNEKRKVRRSLEIYLQTGRRASDIYEEQKKKIRQAALQDDDSCEAGEFEDPDTQLGQARFSLLVFWVHTEKEELRKRLDKRVHEMIDQGLLNEAQRMFKYLQDKASEGVEVDRTRGVWMSIGFKELEPYINELLTAKEEQNSELDKVKEECIESIQTATKIYAKHQTRWIRNKLWKALGTSGMTDRLYIADSTNVEDWNTVVRQPAEEIASKFLSGVTLPHPKDMSVVAKEFFESANAPSRFEVDDIPQMRVCSTCNATIAGADTWEIHMKGRRHKRAIKSAENRRRRDEYFQKLREQSEKNNCEPSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DES7</accession>
    <name>D4DES7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAB GTPase Vps21/Ypt51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000310">
        <property type="protein sequence ID" value="EFE39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020255.1">
        <property type="nucleotide sequence ID" value="XM_003020209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DES7"/>
    <dbReference type="GeneID" id="9582805"/>
    <dbReference type="KEGG" id="tve:TRV_05667"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25639" checksum="38B694C71753646E" modified="2010-05-18" version="1" fragment="single">SSLVLRFVNNDFQENKEPTIGAAFLTQKCSLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPSSLIKAKHWVAELQRQASPGIVIALVGNKLDLTSGDGTSASAGDPAQARDPANEGEEGETQGGSGGNDEQDDERDGSPNGDARKVSTQEASSYSEAEGLLFFETSAKTGFNVAEVFTAIANAIPEASLKSSRGGAGAGGSSGNAGLGTGSRPGDDSRINLRDRGQVGAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ7</accession>
    <name>D4DGJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PI-PLC Y-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019672.1">
        <property type="nucleotide sequence ID" value="XM_003019626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ7"/>
    <dbReference type="GeneID" id="9583560"/>
    <dbReference type="KEGG" id="tve:TRV_06301"/>
    <dbReference type="HOGENOM" id="CLU_039068_3_0_1"/>
    <dbReference type="OrthoDB" id="4169890at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="2">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="384" mass="43067" checksum="F7F160BAA1F59118" modified="2010-05-18" version="1">MVLSTNVLSYTLPVSIIAAYALGIASSIWLFPWAKRIAIYLITQLSADNTRIETNYTAQDESLYGLDHAALNIQLPPTTMWMNMGYWKDNGSVQLPEACEALLDKVLRTAGLDIKSKEGGETAREESNNAKKRVLLDLGFGCGEQTIHLMRNPVRLSPIFDEYIGITLDKVQHGFAQKRLQQKILHENQQEISTRPSKISLFCADAAQPSSWPDEVKKTLYDAFSINDSNNNMERYVMGLDTLYHFHPSRREIFKYSHSILRANLLAFDLFLAPSDPSSLKQIFNTLFLRLLTPALGAPFGNFVSPEAYTTMLEEAGYKTENIVIEDITDHVFVGLAGFLKKRCLDMAIMGLGGYIKWQVAGWLFRWLSSGGILRAGVVIAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGX6</accession>
    <name>D4DGX6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019557.1">
        <property type="nucleotide sequence ID" value="XM_003019511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGX6"/>
    <dbReference type="GeneID" id="9578331"/>
    <dbReference type="KEGG" id="tve:TRV_06431"/>
    <dbReference type="HOGENOM" id="CLU_016758_1_0_1"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="531"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="722" mass="81071" checksum="35052E5BEEFAE32A" modified="2010-05-18" version="1">MDPLIASESATSQATENGRSAETNKTPEQVQEENKFQRAIAVWRGIDLANLIAKHDTTASDIVSHQRDSLVQRKDLAQKTKDFRKLDDASKLSEYKGLLKYLLTNQGKVASSSFLQLYTALSEAPDPYPLLEASIDSLVLSEDTVPKLNAEKDFLQNSVNRLTYQLEETEKRLAEERATRLKLEENQDKKIQEVEASWKAALAEKTSNWEAKEKAFEEKTENHDRLLKELKASYEVSQRLDRSENTEGDTRSAATAAELEIVASDLERTSIRLAEVEARNEQLSLELAQAVSQSQSEQSSRPVEEDPQYLRLQTENSSLMRKLEAARFDKDAEKNTWEGKLRQCERTSSKITRERDELREKLTKFADYDDIKRELEVIKSIEFSTGDDEPDTSVDDSKPSNSKENNLEQLLLARNKKLSNELTILRVSHQDLEGQLGALREELSRTNSELEKSRKLATKLENDLLHIQREATNSSAMSVAGTYVSRYPHGSRRGRVSPTSSIISGFDNSMSPTTMEAIRAGEPVGGGSGILPMVQAQRDRFKQKNSELEEELSKTYGIVKSLRAEVASLQKDNLSLYEKTRYVSTYNRGQASTSSTATPYSNRPNATAIQVDPDTPSGLSLDRYQSAYEAQISPFAAFRGRESARAYKRMSVPERIIFSITRMVLANRTSRNLFAAYCFALHIFLIIMLYSMSTTGIEKHAGIMLDHGTGQNLNGAEDGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH47</accession>
    <name>D4DH47_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000371">
        <property type="protein sequence ID" value="EFE38828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019473.1">
        <property type="nucleotide sequence ID" value="XM_003019427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH47"/>
    <dbReference type="GeneID" id="9577923"/>
    <dbReference type="KEGG" id="tve:TRV_06502"/>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="523" mass="58966" checksum="02DF13300C45D9AE" modified="2010-05-18" version="1">MPTPTTILLPDGYTLNVTPVFGGFSFKAAKLNSSEGSLLPSGWSIVINSLREPKASKTEANSDDYFDETPKNEDKNPFEWESNRYTHPTLDSDYFFISSIHFASSKAVVPKSIATCQLALILWSTLYWYFHQAAPSSRLTTKESAAVPERARPRGEWVVHIRHEGLLKGRNSLLKLERMGLVTTENSIVGLEDPNGPPEKLDMFVSRRSFWQIDPHIFLFSLTPDMTPKSESPSRSGTSSPADSYNTGGRGNRMSASPAPLGSFYSSGHVPSYFPPPPAQWVMLDGWLRHPIRQKPPRQGETFYIRHIPSLQKTLSFRVPSLFTTSPPDTEETALGRYHRALCINHNNMLESIKPLVLKPRGSDLEFLHTILNTPKAKEIWGSGGPVNVQEEFIKARLTSKHLFPALGCWNGKPFGYFEIFWVKEGSVQRPLPVLVDDFDRGIRCTVLDEEDRRPHQTQVWLNALIHYCLLADNRTQAIAVGPRVDDEDLIEAGFYKEGEFALPQKQCAIMRLKRANWEAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHK5</accession>
    <name>D4DHK5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide export protein (CAP59)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019317.1">
        <property type="nucleotide sequence ID" value="XM_003019271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHK5"/>
    <dbReference type="GeneID" id="9577639"/>
    <dbReference type="KEGG" id="tve:TRV_06661"/>
    <dbReference type="HOGENOM" id="CLU_040564_1_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056281" description="Polysaccharide export protein (CAP59)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43845" checksum="6A60B18B91E782B9" modified="2010-05-18" version="1">MALVAILWSFAEVLWVEQALVYQLQSEPSSLGDEKIYITGIHWNNEKILREAWIPALVELVQAIGRDNVFVSLHESGSWDDSKGQLRYLDAVLAQNNIPRRILLNDTTHLDEISKPPASSGWIETPTGQTELRRIPYLANLRNSVMEPLYELKEAGIVFDKVLFLNDVVFNTLDIRRLLSTRGGRFAAACSLDFSKPPKFYDTFALRDSEGHDQLMQTWPYFRSRVSRRAIKYSEPIPVKSCWNGAVAMDSSPFYQDPPLKFRGISDGLAKSHLEGSECCLIHADNPLSDNKGVWLNPNVRVGYNIPAYTAVNPEKMSWLSTSSILSGLWKNRILRWFTTPWFTEYTVRKRLSQYQREGPGDTEAGSFCLINEMQVLVANGWAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHS2</accession>
    <name>D4DHS2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019240.1">
        <property type="nucleotide sequence ID" value="XM_003019194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHS2"/>
    <dbReference type="GeneID" id="9577480"/>
    <dbReference type="KEGG" id="tve:TRV_06729"/>
    <dbReference type="HOGENOM" id="CLU_093582_1_0_1"/>
    <dbReference type="OrthoDB" id="3348320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="218" mass="25470" checksum="008CF67F2771F59D" modified="2010-05-18" version="1">MASPEKKSYLDKRDFEQGLKALDEEMGKNEMIAAFAPIRMIAAGGFLAVMYLQSRNSTGDLDYLLEPEWAKDPDIQRPLKEAIFKIGERLFFDTEWANEDVALFVTSSTREELFRKAEEQNIVLFKGENLVLLAAPMEWAVERKIRRIYAVDRSRKAEFDMNDCLAMLKCLRERQDGPLDREYIRTLNVNSFDVLPDHQVMELIATAYRDKYHEEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU5</accession>
    <name>D4DHU5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_06752</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019203.1">
        <property type="nucleotide sequence ID" value="XM_003019157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU5"/>
    <dbReference type="GeneID" id="9577200"/>
    <dbReference type="KEGG" id="tve:TRV_06752"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="60"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE38558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="403" mass="45869" checksum="A94D55319405EC7C" modified="2010-05-18" version="1">MADGIDRQADENTTERMEFSTSKEVTVAPTFDDMHLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTVLRESQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLEHGQHVVSGTPGRVADMIRRRHLRTRNIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI08</accession>
    <name>D4DI08_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019131.1">
        <property type="nucleotide sequence ID" value="XM_003019085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI08"/>
    <dbReference type="GeneID" id="9580081"/>
    <dbReference type="KEGG" id="tve:TRV_06815"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="36599" checksum="B0CC5F14B25C3DAC" modified="2010-05-18" version="1">MTRILLTGGSGFIAAHVLDTLLERGHSVVTTVRSQEKGQRILDAHPQVGKDKLDFVVVEDIAQPNAFDKAVISEPPFEAVIHTASPFHFKISDARKDLLAPAVNGTTGILHAIKKSAPSVKRVVITSSFAAIIDPAKPSNYVYSEADWNPIKEEEVDKSPIFGYRGSKTFAEKAAWDFIENEKPGFTLATCNPPLVLGPVVHYLASLDAINTSNERISDLITGKGKNSCPPTGTSLWVDVRDVAMAHVLAAEKAEAANKRFFLVAGTYCNADIVEIVSEKFPELRDKLPSGDALAPGLVPLEQRFGFDTSRSKDVLGLTYRPLAESVVDAVKSLQGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI19</accession>
    <name>D4DI19_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019142.1">
        <property type="nucleotide sequence ID" value="XM_003019096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI19"/>
    <dbReference type="GeneID" id="9580089"/>
    <dbReference type="KEGG" id="tve:TRV_06826"/>
    <dbReference type="HOGENOM" id="CLU_020027_14_1_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="9"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="384"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54434" checksum="F85D20F42AE00300" modified="2010-05-18" version="1">MDVLKSPEFAEYVKNTIDRYHVPGVAIAVVQGEHIESAGFGKASLDPPEDCTPDTLFDIASTSKSLTAASVALLVDDNEKHPQVQYDALMADLLPGDFVMPGDGHGDVTLEDILSHQTGMAPSEYLYCNLMYTAASYLVEQKSGLSFSDFLHANFFQPLRMQSTHLQPSAARSNGLSHLLATGYFWNKKGNKYTPIPCHDSPESQGAGRIISSANDYIRWVRALMNCNDPVTKSMYEGMIKKRISQSPPGESGDDEDENEHNHKPSQAFAGAGVEILEYNGHVMVSHDGLDLGFGATHFFLPEQNFGAVIFGNSNNASNVARLIKYKLADWVTAGNEKLYSSLLDGVSSSESDEDEEEEEDEDDFTDIENEMIDELCADGGVRSDQTLALSAYTGEYWHDGYKGIKVTQKQGRLFVDARDRSVKFTLEFMHICDQRKYIAYMVEMNEQDVRDPLKAEFVLEGEKAVQLGLTLEDAWDGYIWFKRVDAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI57</accession>
    <name>D4DI57_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000397">
        <property type="protein sequence ID" value="EFE38465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019110.1">
        <property type="nucleotide sequence ID" value="XM_003019064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI57"/>
    <dbReference type="GeneID" id="9582595"/>
    <dbReference type="KEGG" id="tve:TRV_06865"/>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="522" mass="58979" checksum="0058DB6E6323EA48" modified="2010-05-18" version="1">MVDGDPGSPTWKFTQSVLPDSRSIRAQDLADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFDKSLKVVAENNLSRDLTPAGVVSGGGIARPPRVSFKDSSALKLPRMTHHETVVAAVPRRIYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPTSCNWFMYASSKGTIKLADMRQRALCDEHQKQFEQEEDITSRSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAQNVMTGSYNNNFMIYPTDPTKETEVVLQADKTAFKAKKVGVPTPINSTASTNAGKKNGSRSGSPSGAGGRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNVSSTSSSSSSSSTYTILLTRYLLALCVLRSMRNIAAVSIYPKRPLPHLLWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI95</accession>
    <name>D4DI95_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component Gpi16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019078.1">
        <property type="nucleotide sequence ID" value="XM_003019032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI95"/>
    <dbReference type="GeneID" id="9582564"/>
    <dbReference type="KEGG" id="tve:TRV_06903"/>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056290" description="GPI transamidase component Gpi16" evidence="2">
        <location>
            <begin position="20"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66014" checksum="21BF0F41723AE219" modified="2010-05-18" version="1">MSSLHSLLWTLVVSALLAAANTIDYHEQLVLHPLPPSNLLASFNFRSNESSAAFEQQNYRYFPRSLGQILQHTHTKELHLRFTTGRWDAENWGERPWHGFKEGGTGVELWAWIEAQDADAAFKKWISLTQSLSGLFCASMNFIDSTRTTTPSLTFTPTGTIPHDGLHLLHGTLPGEVVCTENLTPFLKLLPCKGKSGISGLFDGHKLFDASWQTMSVDVRPACAEENSEICHVEIEQTVDMVLDLDRSKRARDNPIPRPVPAAELICDESKPYHSGDFCYPIGASRSQTWSIEDVFGRTIPSSCPLGRDDAQTVCIKVPDSMEVLPSSDAVETRAPDGNSRCYSLHPNQPFNLVVPAQHSSSSYLEAQVVHLERTIIGHGQERGGLRSILTNPSQTDTANFVYFETLPWFMRPFLHTMKTKISYGSEPAVEVPLSDIIKDIFYRPAIDRHRGTQLELVLSVPPASTVTLVYEFEKAILRYTEYPPDANRGFNVAPAIVRVLNRNESIMAPPVYLRTTNLLLPLPTPDFSMPYNVIILTSTVIALAFGNIFNVIIRRFVTLEEAPRRNIKALLLGRVAALKSKLGIKPPEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH7</accession>
    <name>D4DIH7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_06987</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018974.1">
        <property type="nucleotide sequence ID" value="XM_003018928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIH7"/>
    <dbReference type="GeneID" id="9582136"/>
    <dbReference type="KEGG" id="tve:TRV_06987"/>
    <dbReference type="HOGENOM" id="CLU_000846_6_0_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1234"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1034"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="987"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1010"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1011"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1011"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1270" mass="140902" checksum="6983A6E781FB5454" modified="2010-05-18" version="1">MPTNSYTTHPDRQSINSIDDDDDLELEELGVHSSPRFGDSDGHRRPSDGSRWYSPAISLKKLRQKTPKRPWERDIRQSGEDDDLDGLLYDQEHEEAHLSHATISSADDDSPLLTTGQRRPLSRQSSGQARSGLRSRLGLPIFGNRSLAREGMLDRFKRPGSTQTANTVPPREILVGQVQKSRYPPNVVSNAKYTPWSFLPRTLYNEFSFFFNIYFLLVALSQTIPILRIGYISSYIAPLSFVVFISLSKEALDDISRRRRDAEANSEEYSVLSFDRSSLRTPGLTSSKGQAPRWPEPVKITKKSRDLKVGDILKIGKDRRLPADVIILKSLPTDSLSNSQHDAEYFVHDNSEEEHGAPETNEDGELSEAAGSTETFIRTDQLDGETDWKLRLASPLTQNLALPELNRIRITASSPAKNVNEFVGKIELAQLLSESYDPAAEQSGKQDEHSPQLPSAPLSIDNAAWANTVLASNTVTYAAVIYTGSQTRSALSTSASRSKVGLLEHEINSLTKILCVLTLTLSVTLVALEGFEPTNDKEWYIAIMIYLILFSTIIPMSLRVNLDMAKTVYGRFIERDKGIPGTIVRTSTIPEDLGRIEYLLSDKTGTLTQNEMELKKIHVGTVSYANEAMEEVASFVRQGFSASASAGGNELLPFTNASAQPSSGPATRTRREISLRVRDLILALALCHNVTPTKEEENGEVVTTYQASSPDEIAIVKYTEEVGLKLSHRDRQSIILTVGDSGISIKAKILEIFPFTSESKRMGIIVQFSADHYKGCPTQLQNEIWFFQKGADTVMSSIVSANDWLDEETANMAREGLRTLVIGRKKLTSEHYGEFSKSYKEASMSLNDRDSLMARVARDYLEQDLELLGVTGVEDKLQKDVKPSLELLRNAGIKIWMLTGDKVETARCVAVSSKLVSRGQVINTVTKLKDMDAANEALDFLRNKTESCLLIDGESLGLMLSQFRIPFITLAVRLPAVIACRCSPIQKAEIATLIRQHTKKRICCIGDGGNDVSMIQAADVGIGIVGKEGRQASLAADFSITHFHHLTKLLFWHGRNSYKRSAKLAQFVMHRGLIISACQTMFSIASHFDPKGLFINWLLVGYATIYTNAPVFSLVLDRDVDEGLANLYPELYKELKSGKSLSYKSFFTWVLVSVYQGAVIEGLAQILVGEITGPRLVSVSFTALVLNELIMVAVSITTWHPVMIMCIVGTAIVYGASVPFLGDYYDLAYVVTWGWAWKVSAICAVSLIPVWAVKLISRTWSPPSYRKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DII8</accession>
    <name>D4DII8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018985.1">
        <property type="nucleotide sequence ID" value="XM_003018939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DII8"/>
    <dbReference type="GeneID" id="9582309"/>
    <dbReference type="KEGG" id="tve:TRV_06998"/>
    <dbReference type="HOGENOM" id="CLU_083369_0_0_1"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056296" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26466" checksum="303EC766AAD9913C" modified="2010-05-18" version="1">MKSAAILALLAQALAVTAQPVEGDRTPGTRTLDLPNFPGGSVPTRGVEKRADLPPDNGSGNAPDPDKVHIVGVTYGGTGCPDGTVSHVLSDDRQIMTLIFDQYVAQIGPGVNTKENRKNCQLNINLRYPGGFQFSVFSADYRGYANLEKGVSGTQKSIYYFSGQTEQTSTSTTWKGPIDKDYILHDEANQTSTVWSPCGANGALNINSQVRLTATDRNARGILTNDSVDTSFKQIVHVRWQQCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIN5</accession>
    <name>D4DIN5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018913.1">
        <property type="nucleotide sequence ID" value="XM_003018867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIN5"/>
    <dbReference type="GeneID" id="9582072"/>
    <dbReference type="KEGG" id="tve:TRV_07045"/>
    <dbReference type="HOGENOM" id="CLU_049058_1_0_1"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="39186" checksum="761E4B849B9AAE5E" modified="2010-05-18" version="1">MPLFRSFPDIPAQSSQQIALYLTILLSSVISILLSWSLRPVRKRPVSVNYHFTCQCNKSCGFCFHTATTSFKLSIPEAKRGLFSLKQAGMRKINFAGGEPFMYPKFLGQMIQFCKEELRLESVSIVTNGSLVKRDFLERYGRFIDILAVSCDSFNEQTNIEIGRGKGDQVPQLFRIAEWCREYGIKFKLNTVVCNLNYQEDMNPLVEKLQPFRWKCFQVLMVQGENDSDKTLRDVRKFQITDQQYEEFCRRHEHQPSFVAEPNNLMAKSYLILDEYMRFLDRDGREPSASILDVDVFTALGQVYWDETSFNRRGGIYDWSRETNQSSCGSGDSKALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU1</accession>
    <name>D4DIU1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018876.1">
        <property type="nucleotide sequence ID" value="XM_003018830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIU1"/>
    <dbReference type="GeneID" id="9580048"/>
    <dbReference type="KEGG" id="tve:TRV_07102"/>
    <dbReference type="HOGENOM" id="CLU_349565_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="806" mass="86571" checksum="FD088B29FCD7AC87" modified="2010-05-18" version="1">MIALAGTAAKAKTAIKGGVPAPIVAVVLAETAMMENALATVATAALVPTAIMDIVPALTVKVAPAEIAITVDALGYNVAAAPGRNGGGGGGGGGIDGCTGAGCGCSVSGGCHGGDKDGDRDGDNKPTSTASCIVKQTASICAEYCTVITDIAMATMTSCTSTACVPTIGCEPTGTTTTITSMSSDECLHVTPPATFPPNVDPYNGCAPCLIGKAIHGPGIIAQDNIIARDLSQPTYVSLHKRGAAETVTNIGSCTFAKGNSALAPAYTGATQYIAHAISNSLPKSQQMPRWYSKTDSDCVPVVTQVPDADVVGRNGNSKRPSIEHVCKLYTLAYLLPTIKSSMTDEPFIDEKNWLGDFFKYLIQVQGWSCEEFQEHMFMPCNSLQLVYDGLASNRHWDFIGVTAELNIIKTAIGGNWEQDIITNADNALGTENTKITPHTPWAGAKGKLSERMLVLQRLVIACDIWTSDYTFNPLDRTNSRIYSILFNINQPKLPVIYKYWMEHIRVGGVMAIAKKYVDLLVASIEDGLNNSAQKALEVPGGKETWDEWHTSLQRMKDVYKLDYLNDESVCTRPIKLTWKRVPLSEGSAGLGARDVCPLPSAPNTPTPTKATATMDEPPRTPENPSQTSRKPQDPPLPTEPSGGYYCFRDHNENKRWNSFGKEEASKLVVDLCSIADLLPTSNTFGYALRGNNGLVASVTWAQDQTGCSLKFDLPLNTYCAYMFKAMLDACGDLNSDKAYGGAFVDKSKYGCVTWWLGADSTASQDRLLTLGQQSRILTQPEKEAHREMLATLEPELPRLKKEVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ18</accession>
    <name>D4DJ18_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000419">
        <property type="protein sequence ID" value="EFE38157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018802.1">
        <property type="nucleotide sequence ID" value="XM_003018756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ18"/>
    <dbReference type="GeneID" id="9581197"/>
    <dbReference type="KEGG" id="tve:TRV_07183"/>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="169" mass="18641" checksum="081F2F1D16BCB8C9" modified="2010-05-18" version="1" fragment="single">ALSSFLNIHLPFQRQPTPIFNSAADAALSTPPGGQPSGAPVAPSVSMVPYIRRLVATGMDYPGVLHGFFGDDWASGIGSLHEQERRNFFFAAKSGGWAAVKKDYDILPLETIPFLRPLQGSENSEIEAAEKSWSEWLAMEDWMIGPRSPDEMADRQSNTYSRHSRSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJB1</accession>
    <name>D4DJB1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000431">
        <property type="protein sequence ID" value="EFE38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018707.1">
        <property type="nucleotide sequence ID" value="XM_003018661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJB1"/>
    <dbReference type="GeneID" id="9581021"/>
    <dbReference type="KEGG" id="tve:TRV_07277"/>
    <dbReference type="HOGENOM" id="CLU_108553_1_0_1"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="156" mass="16181" checksum="E14F10EC69539CEC" modified="2010-05-18" version="1">MASTTSSGPMPSNTALCGTPTQYDLPVSDVACGVPNQNNNRDLMKMCCNGAPVVAYDNGCALYCLSYKQSAKDLTSCLFDKKIPYHEAWCNSKNVNETATQTSLPSETGSPSESSSPTSPTGSGAPKPTGNSAPVARFSTAFAVIFTVGIIVGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKD7</accession>
    <name>D4DKD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018314.1">
        <property type="nucleotide sequence ID" value="XM_003018268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKD7"/>
    <dbReference type="GeneID" id="9580016"/>
    <dbReference type="KEGG" id="tve:TRV_07659"/>
    <dbReference type="HOGENOM" id="CLU_037866_0_0_1"/>
    <dbReference type="OrthoDB" id="4662583at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="419" mass="48383" checksum="AD475079C13CD39A" modified="2010-05-18" version="1">MIFIILSYLAGVLLVLITSMFWIRRQKTADESGNHSRIQHLKTLKTRHETASDLLELVQIDGAGAWPPRTDFESWPSPLRPYHDIYSNIIPLLSTAEPSLDDAVNKKLVGDFRSRMRKMLAERINLAHVKEIMAAAEAGKWDVFPRDAYNGFYCCIAVSRHAYRWGTIPVVEFAQREQVLELPPELDLPWDYLQRNFGVTAASGNNTANVLLNINKRGEREYKINVAMSSLIKSSEETFFRIFLDIEVSPSIYQAFPIYYEMVCAIISYEDNNRVTCLKYLESISFRLRRLLRLFFENLIESRVSHSVWLSYVQGFQAWGVGRIVNGEVVKYDGLSGNQVLIFQALDAFLGMDSYLSDEQSNRYIPVNQRKICHSLRKHSFRKSAQANGYIKIEYGFKNIVNHLRVWTILSYYSLQIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH9</accession>
    <name>D4DKH9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase (Asi3)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018297.1">
        <property type="nucleotide sequence ID" value="XM_003018251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH9"/>
    <dbReference type="GeneID" id="9579993"/>
    <dbReference type="KEGG" id="tve:TRV_07701"/>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="105378" checksum="27CA0A6FE90B4B02" modified="2010-05-18" version="1" fragment="single">NTTFAMAADKDALATDAMSKAINSTETWHAFLPSEPRDILLLPFRVVYHAEVFIITLPRQLIRFVGLDVAFSSALDGFARVFGIGGGDVAGDDAAAAAAVIAAMTGTSANGALSGDAAAGSAASTEAASGFSMGGFIPSLKKFGGFFNYMTTRWSLACFVVWHTTLILRIIPIVLFATQILKLLRAIRCQTSPQYSIFRYDQPGKQSRLDYAGEGGFLYHLSSSLLQWEAEQSSCSATFTSPGPGVTYGSFSLLWPAFLRLCFGHFIDTLSAALQGKPLATEGGMSIFELSLAFAEAEIQIVRSVGLEFLGITKSTASVSVEGAATGDGASTVPLFSKERVLERLNVTPELLVIALLACCNSLATNLLDVFGKQSQYRLINTTVWGLSFMGFMVWSFLRSYLDGNHAGLLNFPTVCIVGFVPHLLMLLGILTCLAIYTIALLLTAYSLPSNLPRPNSFRERLAIAHGNMQSSTQIQNTRFQMHDDFYATLVRVGYAALSAASDAVFLNEGKSVKVRKMTWLEEDRLAEFTSRRDQSSQECLPRGDDVQLDENFDFAIPNHPRQWESGYGKEKKLERTQSSSQAMKKQSGLGNVGAFRGPTRCYHGFAFFKAIFYMLAGWWAFGLVRLLDHFKLPLKPQWLVHLAGVRQQSSSTNEVAIRPPLDFWILTDEGVLELPETDDFDVEKEMRKREMMVSESWGESQEEHLDNKLYNWWKVGGSWGNQDMTEDYSPPPQDWDTTSVASTSTAEETEWESCDSDGRRTPTPSNPFPGLSRVPEERIDMTSLARLLDPKDMETRDEARILSAHILASSEGKIMTRRRFRQQLDVERARILTSSNACWPAESRRSSRPTMEEELEILENLILERRQGTSQNNIPPLTSENSQTWATGASGLGPDGPQCVICQASPRAIITWPCRCLCICEDCRISLAMNNFSSCVTCRQEVTGFVRLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKJ1</accession>
    <name>D4DKJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_07713</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018263.1">
        <property type="nucleotide sequence ID" value="XM_003018217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKJ1"/>
    <dbReference type="GeneID" id="9579873"/>
    <dbReference type="KEGG" id="tve:TRV_07713"/>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="21">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="37509" checksum="D67BE7ABFBB7A17D" modified="2010-05-18" version="1">MLARSVLRSVPSKAISRQCFQQAAKITADSSSQRSSSTASGSQTQSPFYLTLTASAATATAIGSMAWYYHLYGDEAFAMTPAEEGITNRRDIKNSLHATQYPWEHSKWLKTFDHAALRRGFLVYREVCAQCHSLSRVPWRSFVGVMHTVDEMKAMAEEHEYDTEPNDEGEIEKRPGKLSDYIPAPYKNDEAARAANNGALPPDLSLIVKGRHGGCDYIFSLLTGYPEEPPAGASVQEGLNFNPYFPGTGIAMARVLFDGLVEYEDGTPATTSQMAKDVTEFLNWAAEPEMDDRKKMGMKAVVLLSTLFAISVWVKRYKWATIKTRKIVYNPPIGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKT7</accession>
    <name>D4DKT7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000483">
        <property type="protein sequence ID" value="EFE37530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018175.1">
        <property type="nucleotide sequence ID" value="XM_003018129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKT7"/>
    <dbReference type="GeneID" id="9579552"/>
    <dbReference type="KEGG" id="tve:TRV_07811"/>
    <dbReference type="HOGENOM" id="CLU_014051_1_1_1"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="57903" checksum="BEF14EDAC44C1616" modified="2010-05-18" version="1">MEKESFMSAEVAAILNKSFIPIKLDREERPDIDDVYMNYVQATTGSGGWPLNVFLTPDLEPVFGGTYWPGPNATPLPKLGGEEPVGFIDVLEKLRDVWNTQQLRCRESAKEITRQLREFAEEGIHLSQVNKSEQEEDLEVDLLEEAFTHFAARYDATNGGFSGSPKFPTPVNLSFLLRLSRYPEEVMDIVGREECAKATEMAVNTMIKVARGGIRDQIGYGFSRYSVTPDWSLPHFEKMLYDQAQLLDVFIDGFEASHEPELLGAIYDLVTYITSTPILSPMGCFYSSEDADSQPSPEDTEKREGAYYVWTLKELKQILGQRDADVCARHWGVLPDGNVARVNDPHDEFMNRNVLRIATTPAQVAKEFGLNEEETIRILKTSRVKLREYRETKRVRPELDDKIIVAWNGLVIGALSKCAILLEDIDAEKSKHCRLMAGNAVKFIKENLFDAESGQLWRIYRADSRGDTPGFADDYAYLISGLLQLYEATFDDAHLQFADKLQREFPIIANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL64</accession>
    <name>D4DL64_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018050.1">
        <property type="nucleotide sequence ID" value="XM_003018004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL64"/>
    <dbReference type="GeneID" id="9579174"/>
    <dbReference type="KEGG" id="tve:TRV_07938"/>
    <dbReference type="HOGENOM" id="CLU_081892_0_0_1"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="227" mass="24744" checksum="8C4A15B4159F5624" modified="2010-05-18" version="1">MVTWDKASIERLIAALLAAHPDLSPDYRTMAVYFGQGATYDAIHGQFRRFRQDANKMRGSASGTVPSTPSRRKNVASSTPRSGRGAITKSASAKKSNYGNSNIETPTKKRELKMDSNKDDPIILDDDEENVTTPLVKHEMSEVKHENPVIKEEAKAGEVISMADMFSAAASADNEGPQHEIAATGKSPATALSSETPHLPDEGLLSMPLPPNRVLFFNYDDDEDIIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>P0CH60</accession>
    <accession>D4D4Y0</accession>
    <name>LAP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable leucine aminopeptidase TRV_02148.1</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucyl aminopeptidase TRV_02148.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TRV_02148.1</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable extracellular aminopeptidase which contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EFE43096" version="1"/>
        </conflict>
        <text>The predicted gene TRV_02148 has been split into 2 genes: TRV_02148.1 and TRV_02148.2.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="ACYE01000114">
        <property type="protein sequence ID" value="EFE43096.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CH60"/>
    <dbReference type="SMR" id="P0CH60"/>
    <dbReference type="HOGENOM" id="CLU_366463_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397776" description="Probable leucine aminopeptidase TRV_02148.1">
        <location>
            <begin position="16"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="291"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="357" mass="38516" checksum="DBEE5EDDE03916B8" modified="2010-10-05" version="1" precursor="true">MKVLAALALSALAMAKPTPPMPGMSLVQTGPQETRWVTAKEKHDMVMNHIGFFDITNRPESASIASKPKSYAFPGNVSHQAEVKPLLEKISADHIKSNLEMFSSYPNRYYDAQSGVESAQWVMEQAQAVVGNIQGAKVEMVKHDWMQPSIRAIIPGKSEKIVAVGAHQDSINGKNPQGEAPGADDNGSGSMTILEALTALVSDQKIAGGEAANTLEFHWYAGEEEGLLGSQDIFQQYSQEGKEVVAMLNQDMTGYGETMGVITDNSDPNLTKFTKMILDTYTSAKYSDSECGYACSDHASANKAGFPSAFVYEAVVGQDNPAIHSPDDTIEKLDPAKMAEHAKLVVGFAYELAFATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYW4</accession>
    <name>D4CYW4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025798.1">
        <property type="nucleotide sequence ID" value="XM_003025752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYW4"/>
    <dbReference type="GeneID" id="9582063"/>
    <dbReference type="KEGG" id="tve:TRV_00001"/>
    <dbReference type="HOGENOM" id="CLU_1321730_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23032" checksum="4207E4AE6007CBDF" modified="2010-05-18" version="1" fragment="single">AIGILFTLNGVVGMIVQFFIFPPTAKRFGVLRCFKISALMFPVLYFLTPFLALFPTDSTRQLATVILMAIKLSAVVFAFPSSIILLTNSASSVSVLGTLNGVATSASAIGRAIGPAALGAIFSIGVKAGYMIIPWWTLAFIAAISALPAFWIIETDGFTGDTGEQDNEDTVVVVGDAEQDSPPLLEVGNVRPENTAGPIEASNSDSKAAGDEPTLSAPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ18</accession>
    <name>D4CZ18_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025793.1">
        <property type="nucleotide sequence ID" value="XM_003025747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ18"/>
    <dbReference type="GeneID" id="9582036"/>
    <dbReference type="KEGG" id="tve:TRV_00055"/>
    <dbReference type="HOGENOM" id="CLU_027204_0_0_1"/>
    <dbReference type="OrthoDB" id="4172231at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="464"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="663" mass="74550" checksum="8F8B792FF61121C4" modified="2010-05-18" version="1">MSFFRSTIFRHRRGNNNNTGPPDDEGRDSPHENQRHRATEGGSTELGLPAPEEHPEDIKQSINAVQSFLAARLAMKCYSCASNITENFSVRNWIRRWSEGAKGNPAKGCYLCAATCSSCGALTCLGCGNKVRNSRNPHEIEGYYMDWCCDDGRVFGIWLLLARYDRVEIRWQAPSSVTQNKQPPARNSHSPSQRKTQDARGIGYADDSMGRYSPFTDFFHEGSWFQPVYSNRPLQFHGSDEKEDEFVAKVFDFVGQMIPGPMSKNLPSELHAMLQLGLLLDKVADLLRNDSLDDVTKRSDVYKAAFGLVSKLSSHPELIDLAKCARYHKQQTPGLEILSSSKPQQYDSPPLILGERIASVGERLKQLARQSKIVLESVESQDLNTRSGEDLLLCCESILSLYSVISAGQEGIGMRTRASPQEKWEAFHQEHGVSRDEGVFDRTHAYYSKAITMTYSSPGRIKRMVTEVANMSTSLPIGIFVKVSESRPDFMKCLIMGPPDSPYGYALFETAVGKTINPNLHPDGKVCLSLLGTWRDGDAAAQWQPGKSTILSVLISIQAMIFTEDPWRNEPAYTSAVGTMADIRARRYVEKIQPQIVTAGMLNWLTQPRHRYGIWQKVIRAHFKYNKANILAKVDKWANENPVLKFRGIVQELKLAIEDINRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ53</accession>
    <name>D4CZ53_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025719.1">
        <property type="nucleotide sequence ID" value="XM_003025673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ53"/>
    <dbReference type="GeneID" id="9581962"/>
    <dbReference type="KEGG" id="tve:TRV_00090"/>
    <dbReference type="HOGENOM" id="CLU_041481_3_0_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="23952" checksum="FDC99FD4B58D985C" modified="2010-05-18" version="1">MHTPSGRFMPSTRLCLSISDFHPKSFNPAWEVSTILIGLLSFMNSEEMTTGSVSASDAERRLFAARSRWWNSTGGGSYTKAVPGVTSTIKGIANIKAGDGGKKFRAEWPELDQENWKWMKDNRVDPATGQILPDPNEALLAENSSSGNGSNNSACSPETNALRRRPGGGSATGLGVVVEGGQRARDAGESWFRRNKVWICIGLVLGYALLSRLFDDLRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ79</accession>
    <name>D4CZ79_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025702.1">
        <property type="nucleotide sequence ID" value="XM_003025656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ79"/>
    <dbReference type="GeneID" id="9581945"/>
    <dbReference type="KEGG" id="tve:TRV_00116"/>
    <dbReference type="HOGENOM" id="CLU_127753_0_0_1"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="168" mass="16589" checksum="5B2C7834C10A5A6F" modified="2010-05-18" version="1">MSAKKGSETPQDDNGLSAEAGASELPTNAEDRAAAAALSSLNAPKTAAEGGEAEEDGAKKPSTADQEALGRAMSRLEMIAGGGKKGAAAAGGDKKAKTASTAAVVAAAAAGGEVVKKKAVKVAAEDVNLLVDQLDLTKPKATELLREHDGNAVKAIRAFISPPTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZJ5</accession>
    <name>D4CZJ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025597.1">
        <property type="nucleotide sequence ID" value="XM_003025551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZJ5"/>
    <dbReference type="GeneID" id="9581835"/>
    <dbReference type="KEGG" id="tve:TRV_00237"/>
    <dbReference type="HOGENOM" id="CLU_1062419_0_0_1"/>
    <dbReference type="OrthoDB" id="3794209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="29563" checksum="B0790D388CBB8C07" modified="2010-05-18" version="1">MLKDHDDFEYLILDGDQLREHPCREPLLKLINKAFYEGSRAIYSSSLSRFESLEELLNTVDDHGRCCVLFRRTPGQTTNDWTDPVATAMLRPFREAIVGLPHIKHEPVDASGDVLTGYHDDIKSEYCEQPVRCKGNTQDILSIAMWEPVSVAVKHDPSLLHSGLASRCLALLEADLCSRVNEAKLTTRRQEAAGANHARCEAGPLTMRLRATWEINGDYWSRRGFTPVEVRRVPAGVWGAKVPFRLMTMTKTIHCSSDRNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZK3</accession>
    <name>D4CZK3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular developmental signal biosynthesis protein FluG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025605.1">
        <property type="nucleotide sequence ID" value="XM_003025559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZK3"/>
    <dbReference type="GeneID" id="9581843"/>
    <dbReference type="KEGG" id="tve:TRV_00245"/>
    <dbReference type="HOGENOM" id="CLU_017290_6_3_1"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="3">
        <location>
            <begin position="465"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="566"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="899" mass="100709" checksum="596B962BF475A618" modified="2010-05-18" version="1">MADVQALRRLIQTHPLIDNHAHNILSAEYAADYGRYPLESIASEAQGDSLLKDGCKSLPHFRAISQLAELYGCPVELNAVKAAREAAIAADYEELVKKCLHGTHLLLIDDGLDISHSESFEWHDRFTPGSTRRIVRIESLAASILKILLQRTSGDELLFDTPETGDNGDLIFGKYPSSQLLTIFEVAFKSRIKGYLDDVDIAGFKSIICYRSGLAVKKPSTKDLLQSFSSCFQSISTDGSSRIDSKPLNDHLVVTVLSILHQYHLTTGKSKPIQFHTGLGDSDIELSQSDPALLQPVIEEFEAVDFVLLHSSYPFTRQAGYLASSYKNVYLDLGEVFPMISRDGQISVVRQALELVPTSKLLWSTDGHFHPETFWLANLQFRQALESVFTEYVYKGDFTVDQAMTSVADILFNNSNELYNLDQTVSYETIMDLQRATESSFPELFAHRPSETIMQTGQRFMAVYNTIDYYWLQFVDYTATVRVRMLPARQFYRMLQGKSIGITMALMNLLQNDTLGEPGALTAGQFLLRPDVTTLSPNLKRSGNPNSATVMTFWKNSNGKPLEGCPRHTLKNLTDKCKSEFGISLLIGFEVEVVLFMKPSGAKRDHCYNYLEDEDYFTPWVLNHSWSNMTSDTRTALPLVEEIASELLSLGIEIEQFHAESSPGQFEFVLPPSRPLASVDLLIRARQVIVTVAERYGVRATLYPRPSPNHAGTASHAHISVSPTTHENSFLAGMLEHFPSVLAFTFPQDACYARVLPGIWAGGIWVAWGDQNRETPIRKISEGHWEIKSMDGMSNPYLAMAAVIGAGYLGLKNRMELKVKACNVDPMDLNDDGRKELGITTAMPTSIDESIAALKADTEFQELLGKVFVKRYIAVRQGEQRLLNSMSETKRRNWLIEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0K3</accession>
    <name>D4D0K3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_00598</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000034">
        <property type="protein sequence ID" value="EFE44621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025232.1">
        <property type="nucleotide sequence ID" value="XM_003025186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0K3"/>
    <dbReference type="GeneID" id="9580724"/>
    <dbReference type="KEGG" id="tve:TRV_00598"/>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01489">
        <property type="entry name" value="Uba2_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000005">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="17">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="18">
        <location>
            <begin position="448"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE44621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="618" mass="68515" checksum="FB8E32FC9F0F7708" modified="2010-05-18" version="1">MSPHAAHGRDRFLKQSIGSLVPKVHESRVLLVGAGGIGCELLKNLLLSGFGTIHIIDLDTIDLSNLNRQFLFRHEHIKKPKALVAKEVAQKFRPQSTIEAYHANIKESRFNVDWFASFDLVFNALDNLDARRHVNRMCLAANVPLIESGTTGYNGQVQVIKKGRTECYDCTNKPVPKSFPVCTIRSTPSQPIHCIVWAKSYLFPELFGTSEDDVELDHTEDAENAGEIENLRQEAKALKEIRNSMPSDEFTEKVFEKVFHKDIVRLQAVEEMWKSRPKPNPLSYSSLSEESKGIDASICSDDQKVWTVAQNFVVFKDSIVRLKKRLLDGQPETQDGDKIMLSFDKDDVDTLDFVASSSNLRAAIFGLEAKSKFDIKQMAGNIIPAIATTNAMTAALCVLQAFKVLKNDYDSAKMVFLERSGARAINTDSLKPPNPDCAVCAVAQRKIFINPESATLNDLVEKVLRLELGYGEEFSVSNQIGTIYDPDLEDNLPKKLSELGVEKDSFITVVDEEDENPRVNLEILVSERTDDKSPISLEASDADIPRKPKPAGEQEPPVTTQENGISGKLKRTADEAGLEVVEGQPAKKIANGTEDCNNTPTNPIIVEDDTGTILIDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0U5</accession>
    <name>D4D0U5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_00691</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000043">
        <property type="protein sequence ID" value="EFE44526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025137.1">
        <property type="nucleotide sequence ID" value="XM_003025091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0U5"/>
    <dbReference type="GeneID" id="9580632"/>
    <dbReference type="KEGG" id="tve:TRV_00691"/>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="430"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE44526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="963" mass="105827" checksum="1DF8F7622D6A5F77" modified="2010-05-18" version="1">MCYNSDYYNGCVFSLATPLLSPPPPLSRPVFPSLKGKLQLCAVQPVYVYHYYAAGAAKLRAEIGWLFFAGEEAKKEKKVHPSLFLPVSNKYQTSQTDEDEDEDEDRRPTALLLSRSSRRRDETPKEKTRLTVQHCSAPHLSTRSTVVQLLSNIGSKREVQQYLSHFTSVSSQQFAVIKVGGAIITEHLQTLSSALAFLNHVGLYPIVVHGAGPQLNKMLEDAGVEPHFEDGIRVTDGKTLALARSLFMEENLKLVEELERLGVRARPLTTGVFSADYLDKDKYNLVGKINGVNKKPIEAAIEAGCLPILTSMAETPEGQVLNVNADVAAGELARELQPLKIVYLAEKGGLFNGDTGEKISAINLDEEYDHLMKQWWVRHGTRLKIKEMKELLMDLPRTSSVAIIHPADLQKELFTDTGAGTLIRRGNKVQTRNSIEEFEDIEALKNALVRDQEALDARATVDRYVDSLRGKEIKAYSDEPLEALAIVLPPKPGSTLAHLATMSITKTGWLTHVADNVFTSIQKDFPKLTWTVKEDDENLSWFFDKADGSLCRDGEVLFWSGVKEADEVKDLVVEFSKNGRDMLGNLSMESSLNSSAAGGSNPSATVQQKRAFSTAATTASALRSLRQQQQYTRPGFSRSYTTQTNPNPPLGKKNASNTKPSKVALIGARGYTGQALISLLSAHPYMDLAHVSSRELAGKPLQGYNKREIIYENLSPDDVKRMAEQGDVDCWVMAMPNGVCKPFVDAVDSVDKEKAVIVDLSADYRFDDSWTYGLPELVNRSTIAKATRIANPGCYATAAQVGIAPLVPYLGGQPTVFGVSGYSGAGTKPSLKNDVNYLTNNIVPYSLTDHIHEREIGSQLGAEVAFIPHVAVWFQGIHHTINIPLKEAMASRDIRNLYQDRYAGEKLVKVVGEAPLVKNISGRHGIEVGGFAVHSSGKRVIVCATIDNLLKGAATQCLRTFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0W0</accession>
    <name>D4D0W0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025127.1">
        <property type="nucleotide sequence ID" value="XM_003025081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0W0"/>
    <dbReference type="GeneID" id="9580620"/>
    <dbReference type="KEGG" id="tve:TRV_00706"/>
    <dbReference type="HOGENOM" id="CLU_2980778_0_0_1"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6043" checksum="9FB26A015426E6FD" modified="2010-05-18" version="1">MLTDSLNAGVKSFEVSLDAQTAQVITEPSVSYEDVLAVIKKTGKAVTKGEADGVEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0X6</accession>
    <name>D4D0X6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025064.1">
        <property type="nucleotide sequence ID" value="XM_003025018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0X6"/>
    <dbReference type="GeneID" id="9580576"/>
    <dbReference type="KEGG" id="tve:TRV_00722"/>
    <dbReference type="HOGENOM" id="CLU_012644_0_0_1"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="554"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="723" mass="78343" checksum="3ED1C721CEFC933C" modified="2010-05-18" version="1">MPDDDSSGTGVQVSPPSTSSHEYQDYGVGGPWSHLQYPDELKPSDSASRPRTSNRLREPVDPRPSRHRSSRRHHHHQQPRAHTHAHQHPHPQVQQVHAVPSHRSRRPLARAAPPQPPPVPVSPEPDSSEEEEEDEEEDEEDDEEEDEDDYLDYAPNPADRRFWPTPPTQGPASSAPSFNPYPPHQHPPAPPSFPQPQHANAAHPGVPSNQLVQLGSMGHQNPIGGHMGQYSHQQYPYGGHYPPPPQGHHQQLPHGYYTGPDGLPHPHHPHAGQRMPLHHPHHPPHHPHAHLPRHRSRSGSPDDEEDSPKPTMAHPVMSHPPSFPGTPPYMSPEMVPYGYPHALPHHPMLPGAGHPHAQAQAQAQAAAAAAAYYQYIQRVANRARLRKRRVGVHLRPSRHLLLRRLQLPLSPPPPDPKDEAIARLEKLIIEERKEREERDAAREAAIKKAAADKAAAEALAAKEKKIAADAAAAATAAAKEEARIEAEKAAAAAAAKAKKDAEEAAAAAKKEAEEAAAIALAEATAAAAAAGDAKAAEAAAAATEAALKKPPPPKKPVQFKDAIGRKFKFPFALCKTWQGMEELIRQAFLHVDLIGEHVLNGHYDLVGPNGDIILPQVWDTVVEPDWSVSMHMWPIPEKPKEPEPAPPPPPPPEEEPPVAVVDVPAPPPPPPAPKKVVRPGAPGGFAKWMTGGKVKPRPNPKAAKKADAGGTPPPPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D135</accession>
    <name>D4D135_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025044.1">
        <property type="nucleotide sequence ID" value="XM_003024998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D135"/>
    <dbReference type="GeneID" id="9580536"/>
    <dbReference type="KEGG" id="tve:TRV_00782"/>
    <dbReference type="HOGENOM" id="CLU_053382_4_0_1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="18646" checksum="B400F5E63DCD3DFA" modified="2010-05-18" version="1">MPHSQYFQKRDPNFQHNDNNSLRIEFGRLANRQGWTKKNQKYPRQWEKCLREEFEYHVYQVVDEHGDKLSNLKLLCERYLNKTPASIVACKKALRRVHINLVDWIESQRRGDEPHLFRSEKHLQYYTREHKKYFPKKILDDLSIMKVFLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T9</accession>
    <name>D4D1T9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024802.1">
        <property type="nucleotide sequence ID" value="XM_003024756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T9"/>
    <dbReference type="GeneID" id="9580292"/>
    <dbReference type="KEGG" id="tve:TRV_01041"/>
    <dbReference type="HOGENOM" id="CLU_1469243_0_0_1"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21039" checksum="7ECBEB490B24D39E" modified="2010-05-18" version="1">MLTDHVQRRIHLEGELTDTVACFLQFQYTGEYFPRLLPSGKDLEQDPAIPKVDASGEQLLKHARIYSLAEKLGNDKLKLLAQNKIGSIESSATGEIEYARYVYSHTTPEDTAIRGPVARFWAKMSDVLRHDAEEQFKALCLEHPQFSFDLLNRVLDMKEKRARERDNTSSPAFKGPARKRSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D266</accession>
    <name>D4D266_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024651.1">
        <property type="nucleotide sequence ID" value="XM_003024605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D266"/>
    <dbReference type="GeneID" id="9582826"/>
    <dbReference type="KEGG" id="tve:TRV_01168"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="31743" checksum="2246BBDE9A5B78DE" modified="2010-05-18" version="1">MAETPDLAEIHDFLVDLASKAGEMITSAHPLINGAGSKKNSKKTLSLSASTTPYNQEQEQAITDHKSIRFMGEETYDPSKPLTDEPTFVVDPIDGTVNFVHGFPSACISLGFAISQQPVVGVVFNPFTSTLYSAVKGRGAFMNRTRKLPLRGEDVEPLMGLSSALVAVEWGSDRSGPNWEVKLRTFESLGKSKEQGGAMVHSMRSMGSAALNLCAVASGVLDLYWEGGCWAWDVCAGWIILVEAGGIMVDGNPGQWQAKLDSRRYLAVRGAPGGQGQRELVQEFWSHVGGSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D295</accession>
    <name>D4D295_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024629.1">
        <property type="nucleotide sequence ID" value="XM_003024583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D295"/>
    <dbReference type="GeneID" id="9579956"/>
    <dbReference type="KEGG" id="tve:TRV_01198"/>
    <dbReference type="HOGENOM" id="CLU_015328_0_0_1"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59333" checksum="ADB130B925C9A00D" modified="2010-05-18" version="1">MSTPVPPSTTKNKITPKTPENHSAIKPSVGEMHPSKVQQSTTKQPDSGLQLGFRPIHDNSKGPNQSVPSIINTPSKGRISNVDELSKMSFDFKFSCGESQLSQEAKKLMESLREEAARIKSQMVMEKNAQKGKDVEAEAQPTSRKIAKPKGIAGRFSSAHMAQFRKMDSIEGHPSAFRARVEPNKTSPAKALKRTISKAQLGDPEKDVPTKTRITPASRAAATRPSIPRRGGQASASQSTRTPLSGESSQVQNKPPSNPVPLEKSKFTTPQKPTIAPATSIKYPHTVKAQSISRSPARRSLFSAPKTPQTDIKYKSNMPQLKSILRRPQPLFSNDPEKIAAGTHQPLPRADFDTKLLGLSDSFKSSISIPSSKKTVDFSASTKLRDACNDSSPSAVASKSQGSGPRDVLYPTLPPTTPPHERRVPGFTFKLPSPTAQENGSPLRTGEFQPGLERPPIPHGITNKKRRRDDTDEEPHTPRDDRFIKRLKQNPTTPPAMQTPSPVKRRLPATVTPKRGTPVSKVQKGKGLTLSRLNFLATPKIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2C8</accession>
    <name>D4D2C8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024615.1">
        <property type="nucleotide sequence ID" value="XM_003024569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2C8"/>
    <dbReference type="GeneID" id="9579941"/>
    <dbReference type="KEGG" id="tve:TRV_01233"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_4_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24222" checksum="32DFF22E34BFC3AB" modified="2010-05-18" version="1">MGGQVSKLMGKIFGSKEMRLLMLGLDAAGKTTILYKLKLNQDVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYFSEEPRAGTQGLIFVIDSNDRARIDEARQELHRIILDREMKEALLLVFANKQDIPGGTDHSPAHSLFLAPSSTFFFYLQPANSVLQITAMSPQEVTEKLQLSQLKDRIWYVVPTCATTGEGLFEGLVRYSLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D4D344</accession>
    <name>D4D344_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TRV_01501</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024364.1">
        <property type="nucleotide sequence ID" value="XM_003024318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D344"/>
    <dbReference type="GeneID" id="9579503"/>
    <dbReference type="KEGG" id="tve:TRV_01501"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="739"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EFE43753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="970" mass="106706" checksum="29BB70D690CAE6A5" modified="2010-05-18" version="1">MAMAVSFGIQSWIEGGVIAAVIILNIVVGFFQEYAAEKTMDSLRSLSSPTGTVSRDGQTIVIPSIDIVPGDMIELKTGDTVPADLRLVEAVNFETDEALLTGESLPVQKDCDMVFKEDVGPGDRLNIAYSSSTVTRGRARGVVIATGMNTEIGSIAAALRASDSKRRPVKRGPSGETKKRWYVQAWALTSTDAVGRFLGVNVGTPLQRKLSKLALILFGVAVLFAIIVMSANKWSSNNEVIIYAVATGLSMIPACLVVVLTITMAVGTKRMVERHVIVRKLDSLEALGAVTNICSDKTGTLTQGKMVAKKAWIPSIGTYSVGTSNEPFNPEIGEISLDELPPVKMDEEKLAPPSHPDELLKGSPQLEEFLNVASMANLSHVYRSESEGNEWHARGEPTEIAIQVFASRFNWNRDRWVKGEGAIWHQKAEFPFDSDVKKMSVIFRKLSESEDKEMVFTKGAVERIIDSCTSVILDAAQGPVPMTDEIRNDILENMEALAKLGLRVLALASRPYSPADHALEGSDISREDVERDLQFCGLIGLYDPPRPETAGAIAECYKAGISVHMVTGDHPGTARAIAAQVGIIPSDLSMVAKDVADAMVMTASQFDKLSEEEIDRLPTLPLVIARCAPHTKVRMIKALHRRGKFAAMTGDGVNDSPSLKHADVGIAMGQSGSDVAKDASDIVLTDDNFASILNAVEEGRRIFDNIQKFVLHLLAENIAQACTLLIGLAFKDNDNQSVFPLAPVEILWIIMITSGMPDMGLGMEIAAPDIMDRPPQSKQGIFTWEIIVDIVAYGLWMSALCLSAFSLVTYGFGDGNLGTHCNRDYTPECDTVFRARATTFVCLTWFALFLAWEMVNLRRSFFRMQPGSKLYFTQWMHDVWRNQFLFWAIMAGFITIFPLLYVPVINHSVFRHTGITWEWGIVFIESLLFFLGVEAWKWGKRIFFRRQARLNAASDTKEVSRVRGANSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D371</accession>
    <name>D4D371_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exo-beta-1,3-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024330.1">
        <property type="nucleotide sequence ID" value="XM_003024284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D371"/>
    <dbReference type="GeneID" id="9579457"/>
    <dbReference type="KEGG" id="tve:TRV_01530"/>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055948" evidence="2">
        <location>
            <begin position="28"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="511"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="878" mass="93908" checksum="6883C1732268EDF3" modified="2010-05-18" version="1">MARGLVSSLLLGQLLLVLVGLFSPAGAVPTPQYQTPNTQASSYWLSTIKRQGVAPFNGGGAGYKVFRNVKDFGAKGDGSSDDTAAINMAISSGSRCGKGCDSSTTTPALVYFPPGTYVVSKPIIQYYYTQIVGDALNMPVIKAAPSFEGIAVIDSDPYENDGSNWYTNQNNFFRGIRNLVIDLTGLDKSKGACIHWQVAQASSLQNIRFEMVKGGGDANKQIGIFMDNGSGGFMTDLVFNGGNYGAFFGNQQFTTRNLTFNNCNTAIFMNWNWAWTFKSLSVNDCGVALNMSNGGFNQTVGSVMILDSKIKNTPKGVVTSFNAESVPESGGTLILDNVDFTGSTDAVTSLQGSSIVGGGSVIKHWVQGNAWTAGSGSKAKRLPPQVQAKPDVARRDDCPAPAPQPPAQSTAPPYPIPETGEPTRVPTTEPSNVPTRVPTGGVPSGTTGTAPSTPSPSPTGGPTACPSAPVTKARIQTALPQPSKPAILLDKSGKVFERAKPQYENVSADKFLSVKSAGAKGDGKTDDTKAIQAVLDKATADQIVYFDHGAYLITSTIKVPKNIKITGEIWPMLMATGKAFSDMKNPIPMLQVGQPGDKGNVELSELIITTQGPAPGCILVEWNVAEETQGSVGMWDVHFRVGGFAGTQLQSNTCAKTPNTTTTPDPKCFGVFMLLHITKTASAYLENTWLWVSDHELDLADHGQINIYNGRGALIESSGAVWMYGTASEHNTLYNYQIQNAKNVYMALIQTETPYYQSNPDALVPFAPDTKYNDPTFGDCTTAACKKAWGLRILNSTDVFLFGGGLYSFFENYKQECLKTESCQLNMIEVLCSETYLYGVSTKASTNMITSGGKGLVPQKENRSNFCSTIALFHQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D393</accession>
    <name>D4D393_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000081">
        <property type="protein sequence ID" value="EFE43692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024303.1">
        <property type="nucleotide sequence ID" value="XM_003024257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D393"/>
    <dbReference type="GeneID" id="9579423"/>
    <dbReference type="KEGG" id="tve:TRV_01552"/>
    <dbReference type="HOGENOM" id="CLU_2209388_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="13207" checksum="C77EE3F11B76FDA8" modified="2010-05-18" version="1">MRQNRSDEAEDAKVGEQEEKEQEEEEEEEEEEEEEEEEEEEEEVGSLVSGTQRWRVWDSGCDSSDVLLYQPPEFHGHPSLLSPYFTARFFHDEAVTRIESNNHDFWLPLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R8</accession>
    <name>D4D3R8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024130.1">
        <property type="nucleotide sequence ID" value="XM_003024084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R8"/>
    <dbReference type="GeneID" id="9577127"/>
    <dbReference type="KEGG" id="tve:TRV_01730"/>
    <dbReference type="HOGENOM" id="CLU_008719_3_1_1"/>
    <dbReference type="OrthoDB" id="4078573at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="742" mass="82713" checksum="4D64B3DF03B95943" modified="2010-05-18" version="1">MASSVGQQLMQENEFDTSLALSSANPIPSLSESSEVRGSYQLLTTAQGPGQAAERRKSIGKKDAGERDEASAPVGIQPTAGTASSPGAAKGAATSKPKRVRTGCLTCRERHLKCDEALPRCLNCQKSDRQCKRGIRLNFIDTQVAAPPYAAPSPQTWQINFRDESREIASEYLGGSERYRPIKNEEFTKPIGFGFANIMGFSMPSHQTLASAPALLTFPDAPSAEGYESMFQTTQQPPSSNHVVQDQPIPQPPVLTLAPPRDPKPYLNTPEEVLLMQVFVEEVGLWMDSMDAMKHFTRIIPFYALGEPMLLNALLACGARHLHLVNVTYKEEKALFYYNSATQDLLRYLQNPNRDSALSATTAVVLNVYEVMSTKATQRMNHIAGARALIKECHWDGRSTGVGGACFWLNVGMELLSCLHYNWKLAWDPDTWGVDMNMVPAESSIVGNEELWTHRIVYICAKVANYRTTKHQPLVHERQSHEPDVSRQSDEWNKMKAWCDEWERCIPRSMRPLGYLQPWQSKTKSSFPEVWLIKRSSVVARLFYHTTCVLLAKTHPTESQFSENILAIQQSHANDICGIVAHVKDRGVASVSIRCLIIAAECLVNRVSQEQVLDIMDKILKETGWKIGPLQQELVQKWGWNVKTESQPMPQDQHQHQHSHQQHQQPAMTSIPTTSTAAGPMNLNPSLLPPEVGLAPPRPAIPQGIVNPMMAAADFNAANHPYQNHYVAPQNTPQGSYQYGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D484</accession>
    <name>D4D484_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin class II heavy chain (MHC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023957.1">
        <property type="nucleotide sequence ID" value="XM_003023911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582650"/>
    <dbReference type="KEGG" id="tve:TRV_01899"/>
    <dbReference type="HOGENOM" id="CLU_001004_0_0_1"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1541"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2093"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2262"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2378"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1964"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2058"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2134"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2093"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2108"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2269"/>
            <end position="2284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2417" mass="267375" checksum="881DA78EC10DBC4E" modified="2010-05-18" version="1">MSANININIVFPTSFQVSFLPLAIVLHGFSPLFASYFSSSSSSSSSSLVFFFASSFPVAFLIAFDIPLRRTIRPREDPKTKKRPSFVSHGPTLAVNSPNPVILQPSLHREDDEGEVEREHTLTLPLRRSVTPGAVSSIAAGTSLAVPSAGGYRGPTSDAQSSTFSPDNKRTDASAYYTAAWGSPYATPSSRSVSWQLRSRQGDFESELDLENSPFSIRTTARGEEQLLPDSASQTGIVPFPELTSTLFERDLQPESSVSRHRGKSIKDFTQDWINQYLTGKPRSERTNWLSDDSGDSDVGSFLTAYQQRVDGSEGWLDLDDDDDDDDNANNNNYYKEDLLKTPTASSLLKGKRPEFGWKSRPAHLRAKHAPKASTATLKQSDFWDFGQDPEPSSRSQSRSQSRSQSQSRSHSPARSQSQSEACDQDCASVTMSNLEPLTIPEVRPPPQQHTYVSPTDKPLPLPPTPVEDALDKPLPSGPKETIRTAPAFLRPKKKVAWRGKQCIIALPLEDSRGSAEGGKRLLTPADVEQILDSWEEKGYDVRGTGRGEPVTVDLQNRQTHPDPADTRRELEEKQFHVSFPDQSVWEEYVDFLKEEKLRALGVSLGDPEPNPIMSPTPGAMSRNSSQMPMLPGHTISPPVPTSSAGSNHLNMMQNPFSPAFNQSTKATSNISSMNSPASPFGFHPESPFQQFQPVYGNETNYPFLPFQPTPPAHGTHTPQNLYGIRPNGITPTNIGNMPNLGSLLHSVSPILDESKQYPGMASMLPHSHFNNPYGVSTPQGRMNEYENTMHHQPMDEPNVEMEGEADTTLQPTHSGPEIAHPTPRGHRHNVSETLQKGVERDYQMENPVLEDEPRVEDNLMNSRWTAPEQQMGQQHSFFPSESINQSSQLQQHIFNEQQAHKSHIEEEASDLETNPSIKDVRSPVDDYHTHQAKQSTGSTFIPGHKSTSSISKLNVAAKAFDPSISSFSPTNFSFMPNNTFQPTFSSFHPRPAFNQDVPQSVSHSAHSSGFNVEAPAFAPIQKPQEPISTPSNFKFSSATFNVAAPVFNPGTSFTLPSSEQKPSPSGPRTKIFDNFDPAAIIPPTKASKAIPIVRPGDRKESNDQPDGDASGRFGAQGREKRARRVESHGGDHSDTTRELMFTMSPAAAADSKRTATLIEDSDEVPPEIAANRKRTEEEIIETILSAHDDDLEEVEEGEIVEENDDIKQFEFKNKEDAAAFNAAHPSILADEKIADDQETLESQPAQPEVGADKDAAVDQEEQDTIVEGDDQEEHESLAENIADQPKTSVLKPTAKPFEFISSKPPVLKPISPVASPLQTPISKPKKQGLYASRYAVSEPDSPEPVRSQSALTASLKAAEQAEEVEEDEKPTVEGANSSDEDEIDAVMKQLNDGDSSVGVERRESPSKPVFQTSSANNSVSNLAQSQVSRSDAPSPCLLDEPPFEQESPEVPTYERTQPPSAPLVQRKPAVGGPPSIRQLNTQPQDHISDWDDAILSGDDLELRQRAPFFETHVKDIVRSSMGDHLAPIERSLSAIQLAISQNPSYKPRSTRVEHSDADDEDDEDDGDHRPRSPRNKHDKLAVRIKAIVSEALATHRPTPVPEPAPKVDLSEVTSTLAEMKAAIALVSQQQGQTDGIRDIISQSISDHPALKAKEAVVEEKPDLAPEMEKLKLQVEGLQSMLRLADERAENEYNARRAAQDALALAQQRSEAAEQGIMAEREAKAAAEEALELVKSQHLSQTQKIEQHSRDLQEQQEMMRLTLSELSNKNIDLQGTLDEYRTSADQARAEKERFEEENNDLLRTIEILKIQTDEGTDVKQKLRERFEKLQGDMTSLIKNIANEQAEWRKKEVDANIKYNTLKAEFDREHKQRQKLELHISDLEQKEMEATKLRFILDQSQNENDKLEALLMKVRQESHDHQARAAQFEREAKAAIENSHFEAERVRALLETDLSAAHHQVNFVRTELEAQISNVQSLLDNAKMDSETAKARYELLLAEARDSKLAALHDAAESKEVAIQDQRRLHERTLNDLRERHARAMHNTSEDRQRDEAHYMEVVALRDEKIEHLQERVASLEEKLEIAKSAARAAAEAAQTAKAAPAPQQAVQTTSPSMTYAQGSEVPDKISPQALRESIMVLQDQLQQREGRIEELEQELSTIDRDAPAKIKEKETEINWLRELLSVRLDDLRDLIRAVSQPSFDQHTVRDAAIRLRANLQMQQQEKERAMSGGNSQFPSIASLTSLASSPRALPLAAAAAWGKWRKGNGGGSNNNNNSAPTASSSNSSHNDDQLTPSKPPKPALTASQGFLSGLMTPPSSNTRGPPVVPPAPIGRRTYAETRPLRGQNPGIRRLSSRQLENIMPPTTPPLLRNSSYDHDAETMHYGASSSTDDNDNDSVIGGLIGRETGTRSIEGPFGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4R7</accession>
    <name>D4D4R7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000110">
        <property type="protein sequence ID" value="EFE43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023771.1">
        <property type="nucleotide sequence ID" value="XM_003023725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4R7"/>
    <dbReference type="GeneID" id="9582349"/>
    <dbReference type="KEGG" id="tve:TRV_02083"/>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="208"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="437" mass="50000" checksum="99C16416A38142D3" modified="2010-05-18" version="1">MGKSSGPRPSGMDYKPGNKLKRQELHIKRKQTKDKETRALRFARRKEEAKNPQLKAERLKRNVPLTLERKRVWDDAGSDVEDGLGLSFDVERIKRRRQETEQEQKDKDDLIPDDKEDSEDGEGDADEGGDGSDDVDSMIDFDSDSDEGDQQEEEDKKPAGKDRRKNKVPSATERATSPTQSTRSTNIDLAPDALAAKFPSLFPTEAPPPPKILITTSLNSTLHKEAKVLTEFFPNSVYIRRSAHRYGHKFSVREISSFAANRNYTAVVVLEEDLKRVSGLTIVHLPVGPTFHFSISNWIEGKKLPGHGNPTSHWPELILNNFRTPLGLLTAHLFRTLFPPQPEFQGRQVVTLHNQRDYIFVRRHRYVFRDKRETEKCVVDANGVEMKGVEGIRAGLQELGPRFTLKLRRIDKGIQRKSGQDWEWKGRMEKVRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4U3</accession>
    <name>D4D4U3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial peptidyl-tRNA hydrolase Pth2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023723.1">
        <property type="nucleotide sequence ID" value="XM_003023677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4U3"/>
    <dbReference type="GeneID" id="9582291"/>
    <dbReference type="KEGG" id="tve:TRV_02110"/>
    <dbReference type="HOGENOM" id="CLU_2005562_0_0_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="124" mass="13555" checksum="4259F82D1F94CF8F" modified="2010-05-18" version="1">MALPVDRPTSTAALVIATSVLTGVIGYYLGQGASIGIFSSSPSHAHKGKSIADEDDEEEDEEEDEDDIEGELATFEGNTDEVKLVLVVRTDLGMGKGMPFINYVELQIFPFNRNINFPAQDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V6</accession>
    <name>D4D4V6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TRV_02123</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023736.1">
        <property type="nucleotide sequence ID" value="XM_003023690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V6"/>
    <dbReference type="GeneID" id="9582271"/>
    <dbReference type="KEGG" id="tve:TRV_02123"/>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="348"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="591"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EFE43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="957" mass="106661" checksum="BA987707A8B76D23" modified="2010-05-18" version="1">MSSDAQQSAPSGAPEPEASKGRPLESASDGTRDNTEGPPSKRVKLDDESPVTTSPKPKDGPERRKGLAPIKAEYIITFPKDGYDAPANNNSGRDDDAAEAAGYNDRDGEGKQGKKRREKQKGKNTNRRFQRSQDEKGLCGTITHNPEFSPKPCQYGDNCKFEHNLRKYLKEHKKADLTTFGGVCPVWDAFGVCSAGWRCRFVGSHMAEREHEDGRKKLILVEDEEKKKKAISSSATTSSINATELGVVNLVSTENKQLMTRKKYLTPKADAFNDWITVTSKELEERFHGRNFEEEADGKETNGKAEVDGNGEAKAKENSEENRARYTEPPFLPSEKRRLYFGPETPVLAPLTTQGNLPFRRLCVELGAQFTYSEMAMSLPLMQGTKGEWALMKAHESEILPPTISPKQPVVKGYDHSRDLKFGAQIAGNRPWQALKATEILTALCPHLRVVDLNCGCPIDLVYRDGAGSALLEHPSKLEKILRGMNAVSGEVPISAKIRMGTKDNYPTALKLAERLVIGGYESNELGQGPAGIGALTLHGRSRQQRYTREADWEYISECSALVKRLNAKRDEVSDTIREPDERHLPPGGKVYFIGNGDCYSHADYNTAVDKSGVDSVMVARGALIKPWIFEEIQAGQYLDKSSSERLAYIERFVKHGLEAWGSDEHGIGTTRRFLLEWLSFTCRYVPVGILEYLPPKINDRPPAWRGRDDLETLLSSDNYLDWIKISEMFLGPADKDFKFTPKHKSNSYDVAEGSRDMSLLLDPAGQVQVNVDDEAGLNAVYINPLNSPNFPNPFLFLFYFQPHETSSLPPSPYWGCSITLHVHEIHHLPCLLLLRPAVEQCPATPCFPGDSAFFRHIDINIPECIRSGHGGSMIQGSLSLGDAHPKTAQRPCLACTKMSDSPTRPRSPIQQEEFDPTPIPHGAQGPFPAGYLERGHHPRYGRHAFFARQFRRRLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4X3</accession>
    <name>D4D4X3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solid-state culture specific protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000114">
        <property type="protein sequence ID" value="EFE43089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023707.1">
        <property type="nucleotide sequence ID" value="XM_003023661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4X3"/>
    <dbReference type="GeneID" id="9582255"/>
    <dbReference type="KEGG" id="tve:TRV_02140"/>
    <dbReference type="HOGENOM" id="CLU_042176_1_0_1"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="164"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="50380" checksum="F8FEB8D8D682B6DC" modified="2010-05-18" version="1">MTVNTQVILDYTLNDLYSLDNDGSPIPALVLDSQPVEDHAMVPSAKYVYHLAAQEGSDKMLILLTRSQTERRVFLAGNMPVFIVDFAYSQQHPDSQTMAADKADMYRHFSKMRPDQQPALKFVQRADQITVPPNVPVAVVVPIDLFAALPHVLDPDVHFCILAKRGLAVSGLPTPPSTVVDVALPLDQLRDDTKMGQEISRMLELIDTYNTPFVVKLPQSVAAMGTFAIRSDNDRERVKAILSTHMRLMLKQINAANYHLNPCSLVFQNFVSGTEVALSFFVTRTGRCIFVGCFDQEFDKQGRWTGGSISYPDQPALEEKYAATMEKTAKFLHEKGYYGPAGVDVLTDSQGNQYIVDLNVRLTGLCHLGFLKGHFTSRGLDVASTVTGFFTCSRDKIEEIFCNEFQKGSLVIISWSYDDSMKLSCGAIGVGGKTASDIERLAARMHEYTTPGGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4X6</accession>
    <name>D4D4X6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000114">
        <property type="protein sequence ID" value="EFE43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023710.1">
        <property type="nucleotide sequence ID" value="XM_003023664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4X6"/>
    <dbReference type="GeneID" id="9582258"/>
    <dbReference type="KEGG" id="tve:TRV_02143"/>
    <dbReference type="HOGENOM" id="CLU_041093_1_2_1"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="26585" checksum="EE5305035C38E9A9" modified="2010-05-18" version="1">MAVQIEVDFAINGEGTLHGDGMALWLTEGRANQGPVFGSADRFKGLGIFIDTYKNGRQGMTFPLVMAMLGDGNTPYDQARDGQANELASCSARGIRGSSYPTKLRLTYFQDKYLALDLQYKSDMAWTSCFKIQSRPESPINLPAASYLGFSAETGELSDTHDILEVDVYSLYTKQGSDSTGPGQMAQSANQRNAQREHSYHAANSGGSWLWFFFKVILFFVVVIGGYVGWTAYRAAVSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D502</accession>
    <name>D4D502_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023663.1">
        <property type="nucleotide sequence ID" value="XM_003023617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D502"/>
    <dbReference type="GeneID" id="9582210"/>
    <dbReference type="KEGG" id="tve:TRV_02171"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF52">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="51179" checksum="AD5FB0E4DC29782E" modified="2010-05-18" version="1">MSLSKNPISAELIEILKSQVKSSEILTPSSAGYSKAIARWSDAAVKPAGAVLLATNAEDVSAAVKLAQQHKLDLAVKGGGHSVSGTSSSDGGLVIGLSCMRHVEVDAERRTITAQGGCLWVDVDEAGGQHGLATVGGTVNHTGIGGLTLGGGYGWLSSKYGLVIDNVLSVTMVLADGRIVKTSATEEPDLFWAVRGAGHNFGVAVEFVYQAYEQADLVFSGFLIFPQEKLEAIVDTLNRGMQHPQPDSSTMCIFGTHPGTAEPMVATCIFHRGTEEEGREAFKDLYAIGPVMDGAKMIPYSTVNAQVNEMAKHGARRNIQGLYFSPPLRPAFARKVMDKYAEKMAADPDMMGTAVIFEYFDMRKCTEVPIESTSCANRGATLNGLLTSRWNNKNNDSANRQWGRDMQQMFVKEMEQSTSAVSTNEVPQYLNYSESSDTPFQKMHGIHAGRLQKLKGEYDPTGMFGKMCPIMPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5B2</accession>
    <name>D4D5B2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023535.1">
        <property type="nucleotide sequence ID" value="XM_003023489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5B2"/>
    <dbReference type="GeneID" id="9577007"/>
    <dbReference type="KEGG" id="tve:TRV_02282"/>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="143"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="331"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="660" mass="71797" checksum="8060ED6ABE6AC738" modified="2010-05-18" version="1">MLSRPPLSTHHRLASVASSSSSSSSAAAAAVARTRTLTSRSAGPLASLPLRSKPSMLGPSLYCPQYNAMHSSSPAQSPAGSTGSPVDGYLDTANPGYIRKYLRTYGLTPPRAESYEVQKTRCLAQLALKSTPIEKFLYLSTIRKNSVHLFYRLVMDHLQELTPLIYTPVVGEACQKWSEIYQQPEGMYLSYEDRGNIAAVIQNWPQPNVDITVITDGSRILGLGDLGINGMGIPIGKLALYTACAGIRPEATLPLTLDLGTSNKALREDPLYMGSRRGKVTQEQELEFMDELMAALTERWPGIVIQFEDFKNPFPALEKYRHNYTCFNDDIQGTGAVILGGVINAVKRSGVPPKDHRAVFLGAGSAGVGVAKQIVDFFVKEGMTEDEAKACFYLVDTKGLVTADRGDRLAAHKVYFARHDNNGQQFKTLEEVVDHVKPTMLMGLSTLGGVFTPEILKKMADNNKQPIIFPLSNPSANSECDFKSAITHTDGRALFASGSPFPSFSFKNSAGETSTYYPGQGNNMYVFPGIGLGTILSKAVEVTDSMIYAAADALSTSLTTEELDRGLLYPEITRIREVSVAVARGVIRAAQEAKVDRETAIRTFTDSDLDSWIKSKMYNPHSEVNSLEREVGILLSSIGRMNGTSNGDISPRGEDQGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5H4</accession>
    <name>D4D5H4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023597.1">
        <property type="nucleotide sequence ID" value="XM_003023551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5H4"/>
    <dbReference type="GeneID" id="9577069"/>
    <dbReference type="KEGG" id="tve:TRV_02344"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="547" mass="61454" checksum="72DFB644BEE9E8C2" modified="2010-05-18" version="1">MAILLGLGLSVALTFLLVSYFPKYSISGSFARTLPVLFTTYLAIRAVYLVILYPIFFTPYKHLPVPPGRSIWNGHFKILQASSQGTPSAKWTREVPNDGIIRYYFMLNRERLLVTSTKALADVLVNRAYDFAKTRALVASIGWVTGIGVILAEGDVHRLTISKKVQRKNLNPAFSFRHIKELYPIFWQKSVEMAERIAEDIAPLPTDEKIISFADYTGRATLEIIGLAGMGYDLESVNELREEYRKMFTTPGPFTRLIRNVVFLTWPELFFYLPLPYVRTITAASQKIREISRLLVQRKRYELSSKKIDDSSGDIISVALESGNFTEEGLVDQIMTFLAAGHETTSIALQYGTRILCTHPEVQSRLREEVRAKIPSPGQNKDVNGLRHISSTLLDTLPYLNAFCNELFRFYPPVTVTTRQAIRDTVIAGQPIKKGTNIVIAPRATNRNPEFWGEDADVFNPDRWLAPGCANTGGAESNYAFLTFIHGPRSCIGNTFAKGELMCLVAVLAGRFEMELEDPDKELEITPGITNRPADGVRARLKVLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D619</accession>
    <name>D4D619_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02542</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023316.1">
        <property type="nucleotide sequence ID" value="XM_003023270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D619"/>
    <dbReference type="GeneID" id="9583335"/>
    <dbReference type="KEGG" id="tve:TRV_02542"/>
    <dbReference type="HOGENOM" id="CLU_001485_3_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="930"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="455"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="677"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="772"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="939"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="968" mass="107860" checksum="D9694AE7F53F679F" modified="2010-05-18" version="1">MASGASGGFNTIKVVARFRPQNKVEIANGGEPIVEFESEETCRINSKEASSSFTFDRIFDMNSKQSNVFDFSIRSTVDDIMNGYNGTVFAYGQTGAGKSYTMMGSDIDDPDGKGIIPRIVEQIFTSILTSPGNIEYTVRVSYMEIYMERIRDLLVPQNDNLPVHEEKSRGVYVKGLLEIYVSSVQEVFEVMRRGDTSRAVAATNMNQESSRSHSIFVITITQKNVETGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSTHIPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDAETLSTLRFGGRAKAIKNKAKINQELSPAELKHLLKKAQSQVTTFETYISALENEVQVWRTGENLSKEKWTTLRSTDTVGNLKADARTPRPGTPSRLQSDMSRSEAPSRPESRFGERSSTPSIVLERDEREEFLRRENELQDQLAEKETYIANAEKEVQEKKEELKILKENAVRTGKDNEKLNAEVNELRMQLEKVSYESKEQAITMDTLKEANSELTAELDDLKQQLLDVRMRAKETSAALDEKDKKKAERMAKMMAGFDMKVDVFSENERKIRNLIERVDSLHATSSAGEAVSPEEFVELRGSLVEAQGVIRQAELAMTSREEGFNGAFDGKLLDKIAVLQQEVDDLLEQNLGEADISEIKEKLSQAYSEGNELEKMAMEHLRRELSLRDEELTRLRQSVADSTARSQPNGSSASAGGSATINSKTLQQQIADFDIMKKSLMRDLQNRCERVVELEISLDETREQYKQVLQSSNNRAQQKKMAFLERNLEQLTHVQRQLVEQNGSLKREVAIAERKLIARNERIESLEALLQESQEKLTAANHRCVLNQYHKYIITKEANLSFSSSTHRFEVQLTAVKERLEAAKAGSTKGLSSDSAGFGFGGSRIAKPLRGGGGADAPSNSTLSGVQAQDSSTSAGPKRSSWFFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D630</accession>
    <name>D4D630_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023327.1">
        <property type="nucleotide sequence ID" value="XM_003023281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D630"/>
    <dbReference type="GeneID" id="9583347"/>
    <dbReference type="KEGG" id="tve:TRV_02553"/>
    <dbReference type="HOGENOM" id="CLU_060350_0_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF35">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="35"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="318" mass="34913" checksum="478F81FC36559D10" modified="2010-05-18" version="1">MTNSDGLKDWDSPYSFFNPEYHIKNKDGSVRVIDGGLGRFLGVWNASVNVIYSYVAVDIFAATAAESKSLADSECMKMAARKITLRIVILYVLAMLTCSFLVPYDHPFLNGEAVSLATESPFVIAVVEAGLPAAGEFFNGMYLFSSFTCAVNSVYVASRVMHTLALRDQTGPEFITKRLQQCHAGVPTRAVLATVAILALGYLGPGKGPGDRLRELSSNCTVSFLIVYGIICATYLRFYQTLQEANSLGNTAESQNGVYDRQNPRYPYKSHGQWLKACYGMVSCFILLVFNGIPAFLSDPFDTRAFVVSYISGFCVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D644</accession>
    <name>D4D644_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02567</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023293.1">
        <property type="nucleotide sequence ID" value="XM_003023247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D644"/>
    <dbReference type="GeneID" id="9583313"/>
    <dbReference type="KEGG" id="tve:TRV_02567"/>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="861" mass="94063" checksum="95A82C066D712D79" modified="2010-05-18" version="1">MPLNDDAGEKVARLHSRQAQYDLQMDQIKAAVKTPMPPRRFNTYDGVSDSPHTPRGSVRGRESDVDGLGRAVTPMKRVPILANFEEWMKMATDNKINAANSWNFALIDYFHDMSLLKEGDGVNFQKASCTLDGCVKIYTSRVDSVATETGKLLSGLADSGNKKKQGQGEREDGAENGDEEDEEEEGEEGEDGTRRKTRKKARSHESTLAPSFASLQLKKFELEFSVDPLFKKASADFDEGGAKGLLLNHLSIDGQGRIVFDSSDDANANTTADSETQNKGNEETQGDGREDGSKSPSPRPATSDSSDDYLDVDIRGLAERFFPNLDILSDHDICPSLKDFDLGDPSGSLEIPFLRAPEDWRHDKQQSEQPGLGDASGIVLDDDIAIGFDDDDDATITGFDLGGEAEFGQGGEAWARDAALEPMLKVHRISNIGVGDNNDTTIGFDNDTTENDPFALSLSHGNRAHDHDNILSYFDNALRKDWAGPEHWKIRRMKDITATTTAPRQRKEKEPFEINFAADLEPAVAEMIYATSGSNSAISLPKSQWKTKGRNLLPDDKHFNSKELLRLFLKPKAKMGLRGLKSSNRSRQHDASGPNNGEMDEAFWASQKQSMDQAANDENAAQGTYDANFFADDDGLAFPHGLPIGDDDEDDNIPFADAREAFSPPLDSDAQPSTASGGMTGLNALLNSVATPGGALLGGYGSQLVTQGGRRVRPEYVNYARVAKKVDVRRLKEVMWKGMGERLVASMSFNSASPSAAVTSTTTPADPAPESTAGETPPNEESEDLKNSLRFTDVMNGLKESYPEQAMRDISTSYGFICLLHLANEQGLVLKNRGSMEDDWEGRLEEIYVTKDIGAVIEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D647</accession>
    <name>D4D647_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023296.1">
        <property type="nucleotide sequence ID" value="XM_003023250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D647"/>
    <dbReference type="GeneID" id="9583316"/>
    <dbReference type="KEGG" id="tve:TRV_02570"/>
    <dbReference type="HOGENOM" id="CLU_1887260_0_0_1"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="15079" checksum="0E1CF12BF058C833" modified="2010-05-18" version="1">MVDDEHSSPSSWDLVRRRLKSRLILVSDTDSSLVTNSYELPSNKALGVPSTAIFTFNKEDHTLGNLIRSRLLQNQHVLFSGYRTDGQITPKEAVLAACHDLVKDLGTFSREFTKEYELRKMVGAGTQQNDAPNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6M0</accession>
    <name>D4D6M0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023126.1">
        <property type="nucleotide sequence ID" value="XM_003023080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6M0"/>
    <dbReference type="GeneID" id="9583146"/>
    <dbReference type="KEGG" id="tve:TRV_02747"/>
    <dbReference type="HOGENOM" id="CLU_715728_0_0_1"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="43342" checksum="8C4D84D50B86A87E" modified="2010-05-18" version="1">MASATTAAAAKTVRLFDPTTAVTTHAVRFPRTQGKQIQGKVRFPNSQAAKHFGQQESARLKKALQHITHGKNIFAYNNFRTNQVVYSLSRSLDWQNVQSQLVYHGKKTVPAALRKDMWVPYFSVHFPTPSLGLEAYKLLREFSRQRQFEPPAQLITNSKESLERKRPQALDEAKKWDREMSGRIGQIMMKKDRAKVLMDQKATSVADTAAVLAIQAERERRERQQEEREEEASTEDGKSKEKKLSHKARRRVIRAQKRQQAHEELVRQRIEALEKSMSTKGFQAKIDVEGELADYKVREGEVKLLWADLQDAQYARSWPSTVHHGELEPSREHIISPFLKLYGNDHPSSSSGENLIEEDASTSAPAEEPAKKGLRFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7N1</accession>
    <name>D4D7N1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022733.1">
        <property type="nucleotide sequence ID" value="XM_003022687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7N1"/>
    <dbReference type="GeneID" id="9581421"/>
    <dbReference type="KEGG" id="tve:TRV_03115"/>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="390"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="588" mass="63738" checksum="1790058974E72F5B" modified="2010-05-18" version="1">MLKTKQGTGDVAIPTRGQGGLQHGSSLEELLKVQLSRSFSLHFQRSPSKESKGPFQTAIVADLWEATFDICFSPGRSISLCVPPVRLSACPPVCPSVWLAALAGCSACLCVRGMHEVKNFPFGAMENESSLSSKARAADQQLQHQQRDTGRVTNTTIQTMSVLLETSLGDIVIDLLTESSPRACENVQKGFSFQTGDPLGPDSPESDGGSSIWGVINGPSQKNFTVRFPPKLKHSELGTVSMATVPSAKDADERLAGSQFIITLGDNLDYLNDKAVIFGQVVEGFDVLEKINTAFIDDKGRPLKDIRIRHTVVLDDPYDDPPGLQEPPESPLPTKAQLATVIIADDEDLDQEADEEALERIRREREAQAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLNLIFSRFGRILSCEVIRDKKTGDSLQYAFIEFEDQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSDSWRTATNAKRSSQGGGFGGISNLEKRRQYRAAEAGDRRSKARGLPAPQSLVGEIALGVAAGVEALPVIRIATDPPDAVMGMTGGHGGTGKGTGALTQDMMNETMAVHRDGGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7S8</accession>
    <name>D4D7S8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022701.1">
        <property type="nucleotide sequence ID" value="XM_003022655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7S8"/>
    <dbReference type="GeneID" id="9581359"/>
    <dbReference type="KEGG" id="tve:TRV_03162"/>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28131" checksum="1A586CCE49C70E12" modified="2010-05-18" version="1">MKGKLKGAEQGHSLLKRKSEALTKRNSDFSFLLEITRRIDDAKRKMGRVMQIAAFSLAEVTYAVGGDIGFQVQESAKQAHFRIRTKQENVSGVLLPQFESLTTDGNNDFGLTGLGKGGQQVQRCRETYARAVETLVELASLQTAFVILDEVIKVVNRRVAILTNIHADINSELDELDREEFYRLKKVIYPLLAKMQQLLNYAIQVSNKKQRDTAALDAEIKAKQQKQGARNKEDGAEPSDMLADADEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7T9</accession>
    <name>D4D7T9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_03173</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022712.1">
        <property type="nucleotide sequence ID" value="XM_003022666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7T9"/>
    <dbReference type="GeneID" id="9581401"/>
    <dbReference type="KEGG" id="tve:TRV_03173"/>
    <dbReference type="HOGENOM" id="CLU_004844_1_1_1"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="413"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="723"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="885"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE42094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115468" checksum="8C5DA63BE81C4DC0" modified="2010-05-18" version="1">MEPNPGGAIRETERELDEKPRNHGQTLPFHDLFISLFNPLNDLKKKPAGPPAARRKAGPTGRNNLSPHELRRNVIERFISRWRQQVGNDFFPAFRLIVPEKDRDRAMYGLKEKAIGKLLVKVMKIDKNSEDGYNLLNWKLPGQRAATAMTGDFAGRCFEVISKRPLRTEVGDMSIADVNSRLDDLAVASKEDAQLPILDEFYRRMNPEEMMWLIRIILRQMKVGATERTFFEIWHPDAESLFNISSSLRRVCWELYLPSIRLEADEARVTLMQCFQPQLAQFQMHSFQKIIERMRLAEDDPEFWIEEKLDGERMQLHMETNSSIPGGKRFEFWSRKAKEYTYLYGNGFYDDNGSLTRHLKNAFADGVESIILDGEMITWDPEQDAPVPFGTLKTAALAEQRNPFSASGHRPLFRIFDIVYLNGKPLTRYTLRDRRRALEASVIPVHRRFEIHPYEVGKSASDIEPLLRKVVAEASEGLVLKNPNSPYRLNERNDDWMKVKPDYMTEFGESLDCIVVGGYYGSGKRGGNISSYLCGLRVDDTHAEDGTNPMKCYSFCKVGGGFTAADYANIRHHTDGKWHDWNPKKPPTEYIELAGGDAQHERPDVWIKPDDSVVVCVKAAAVTPSDQFRLGLTVRFPRFKRLRMDKDWQSALSVQEFIDLKAGAEQEKKEKDFQVDNSRRKKTKRSKKKELTVVGSGEPNVAYVGSKTHIFDGLSFCGLKIQALEVNYADIPIVVMTESVKPMKKSKADLEQLIKANGGKIYQTNNAAKDTYCIADRRTVKVASLQKSGLENVIRPCWISDCISQNEHDTGESSILLPLEPRHMFFTKEDQKEEISNNVDKYDDSFARDTNIAELTEILHKMDVISDISGEERLDIMSDLTLDGDQGWLFKNLTIFFAPCGHLSSVPGEPCVDGLSIRQQLARNITTFTGATVTDQQKNNRITHVIVDPSEDRDLETGKTKNYTTLRSEFATRRTIPHFVTVQWVEECWKEKTLVDEERTYSMLAIALPGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D840</accession>
    <name>D4D840_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_03275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022618.1">
        <property type="nucleotide sequence ID" value="XM_003022572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581277"/>
    <dbReference type="KEGG" id="tve:TRV_03275"/>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056280" description="UDP-glucose:glycoprotein glucosyltransferase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="292"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="428"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="685"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1202"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1477"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE42000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1500" mass="169517" checksum="00F8AC5108EF174C" modified="2010-05-18" version="1">MSTIISWSIRPLSLLLVGLALLPNVSQANPSVNVALSASFNSAPYLVELLETAAEENSTSYFPLLDRIADGRFVDATTEKDLYEQFIQVLSEDGHITDPVALSSFKFALSIRSTAPRIQAHYQYYNSSVENSLMAAQDAVCQVWAHYDGSQYCSPTLEHAQQPLIAGRDESLEKLLPFDRMLVVPNAQDEENQQSLVLYADITSPLFSEFHKAVSRRARDGEMSYRVRYRPSTAASRPAKPLFVSGYGVELSLKRTDYIMIDDRASGKGDSKETPLDSKPTLAVDGLSDSPTADLEPLSSSEVSTLGLNAASFVMNSDDPFDTLIKLSDDFPRHSKTIAGVNATSEFLAEYEENRKNGLQPGINTMWINGVQMSPQNIDAFSLLAHLRQERKLMNSLNELGLQVQEAVKLLSNPTITMAQKVHGSQRYDYRDDIEGGGVIIWLNDLEKDSRYKDWSDDIITLLQPTYPGQFHELRRDVHNVIVPLDLANKEDITLFVEEIQAFVLNNVPIRFGLVPTQLSDLSKEQAKIAYYLNKTYGLESVFSYFTEIYSSQKFNLPSKVDFETAIKDRVPKDDQSIILFEDVLKSTELDALMQKSRGYLKRLAIDRENPPVYANAIPIERDERWMHFLIDRLFKDVQGLQRRIYEGDYKGDVWLPSFYLEEASPKFNTLVIPDDPSDITVKSINDAYSKYKEAFETIPRIPGKGDSGIDKWAQLALVIDLDDEHGAKQLANAVAFHKKNPEVEVLILHKPSMPENGPALSTELHKLLDDGRDLEIDAIDTLLDKETKSKRASADAQKFYSTIQPVITELGADGNGMHVILNGRLIGPLNQTTILDTQDLELALQYERSKRLTPVVIALESLKETDKIRDHLAFARLTSMVALSTISDIPEGTFQRPPMIRTEIFNSWVTKHSAITVSNSEAPLIKIVATLDPATEVAQRWIPILKVLSQLHGVSLRIFLTPLETLKELPVERFYRHVLEPAPSFRDDGSLNRPGASFHGVPQEALLNLGMDVPPSWLVAPKDSVHDLDNIKLSSLKEGTNVDAIYELEHILIEGHSRDMSKNKPPRGVQLLLGTERDPHFTDTIIMANLGYFQFKAQPGHWQITLKPGRSDNIFNLDSVGGMGYSPKPGDDNNEVSLLSFQGKTLFPRLSRKSGHESDDVLEDGSKKQGSAKNLLSQGLDFASGVFSGVSKTRKEKHADINIFSVASGHLYERMLNIMMLSVTKHTKHSVKFWFIEQFLSPSFKTFVPHLAEKYGFSYEMVTYKWPHWLRPQREKQREIWGYKILFLDVLFPLSLDKVIFVDADQIVRTDMYDLVSLDLEGAPYGFTPMCDSRTEIEGFRFWNQGYWKRFLRGRPYHISALYVVDLNRFRAIAAGDRLRGQYQSLSADPESLSNLDQDLPNHMQHSIPIKSLPQDWLWCETWCSDESLKTAKTIDLCNNPMTKEPKLDRARRQVPEWTVYDEEIAQLARTVGAKDIELDHTQHEAKETEPEDTNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D882</accession>
    <name>D4D882_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000171">
        <property type="protein sequence ID" value="EFE41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022556.1">
        <property type="nucleotide sequence ID" value="XM_003022510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D882"/>
    <dbReference type="GeneID" id="9581214"/>
    <dbReference type="KEGG" id="tve:TRV_03318"/>
    <dbReference type="HOGENOM" id="CLU_1189654_0_0_1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="26610" checksum="1639E3D671ED5584" modified="2010-05-18" version="1">MIVSICTSQSMPSGSSIDSTDRSPHVYSSRPKILHQNDGGPVVALPAPFPDHDETLDPFALKCIFAGIFECDKSFEDPEDWKLHVTGHLMSHQPPSKVSCIVCKQVFSNPQVQPVQLQIEMPNQQHQQQQQQQQPVGGEAWQNMLDHILAEHPRWGACGQVEPCPDFDLMRHMYCMGIISTEQFKLLQLTRETPPHLPQNGSAAEPYFIQTSSRRERRQRRPRLSNAGSRSKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D896</accession>
    <name>D4D896_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022533.1">
        <property type="nucleotide sequence ID" value="XM_003022487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D896"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="GeneID" id="9581110"/>
    <dbReference type="KEGG" id="tve:TRV_03332"/>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023552656" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023552657" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="239"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="471" mass="49493" checksum="8AE94B3121C78B7A" modified="2010-05-18" version="1">MALNHARAIGQVSHYACRFSKPGTPVSGQVRQFTTPIDTSIPASKQKFVPSSGTYPKGFKVSGSHAGVKASNTSAPDLALIWSETPCSAAAVFTTNKFQAAPVQVSSELIRKKKGNNIRGVIVNAGCANAVTGKQGLQDARSMSRKADECNGLPEGDSSTLVMSTGVIGQLILNKVPEAQSNLSSTHAAWLRTARAICTTDTFPKLTSQSFTLPSSPGRTYNIAGMTKGAGMIHPNMATLLGIICTDAPIEAPILQSLLSHSISRSFNSISVDGDTSTNDTVAILANGAAGGTPISSIDSKDYTAMQSILTGFTQSLAQLVVRDGEGATKFVTVRVKNSPSYEDAKRIASTIARSPLVKTALYGKDANWGRILCAVGYTPDLAPGTVVPVKTSVSFKPADGSPELKLLVNGEPESVDEERASTILQHEDLEIVVDLGGGASGEAGKGGEEAVYWFCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8B6</accession>
    <name>D4D8B6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022510.1">
        <property type="nucleotide sequence ID" value="XM_003022464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8B6"/>
    <dbReference type="GeneID" id="9581098"/>
    <dbReference type="KEGG" id="tve:TRV_03352"/>
    <dbReference type="HOGENOM" id="CLU_041441_0_0_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="35318" checksum="7118F1F7081FBBC4" modified="2010-05-18" version="1">MVKTRFVCVSDTHGYGTREAAFRLPKGDVLIHAGDITNKGTVEEFHKSAQWIREADFEVKIVIAGNHDAPLDKELYKGHTKFFHGKKVVNSDECLELISAVGITYLDHTSKTIRLKRKNGPRTMFKVFGSARHPTNNFGWNAPFGYPANSPEDARKWWSQIPPDADVVVTHTPAKNHLDLTTHHGNIGCEYLRQSLWSIRPRLSICGHVHEARGYERVIWDVDDTKPGTFGEISTTVGTLPPRESKKMSRVDLTGKTYPRLANEGPEDPARSETCFINAAILATHYPHAGGRKFNAPIVVDIDLPLDDEQESEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8G5</accession>
    <name>D4D8G5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1,3(4)-beta-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022451.1">
        <property type="nucleotide sequence ID" value="XM_003022405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8G5"/>
    <dbReference type="GeneID" id="9580998"/>
    <dbReference type="KEGG" id="tve:TRV_03401"/>
    <dbReference type="HOGENOM" id="CLU_694390_0_0_1"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="393" mass="43370" checksum="DF37B1B95244E1E7" modified="2010-05-18" version="1">MVLNPQQTGFSDDSPPSDSDSYFSSPEYSEGGQLSRFAKYPTRVELPPFSLIKRIFYWTEANYQRSISRLIEDRLDFVRVITNRFPTQEETDALVSQASTMQNMPCYGGVVGLAVGSFIAKSKNAAEEAAANKSASEHFTPNQNRPLLKLNPGELKGRLIRASFILPIFGFIGLVFGEVVGEAVAKINMSTDSRLVPLLKEVGQLDQKEVMARIRRHNAERLAAARRQRNNLHPASQPQRAEYYAANDTSPTNSYGQQGATESSYYQSQPDIQAGYSNQSAIGDSKILRETYRQGETSEYSTSSSYPSTNDYSRDWRQQQTYPPARDSSTSSTEGKSFWDDDASPVSSEFTSTPDSSSSPAPHSGSAWARIRQQSMGDSSANAGNNNTSSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8H5</accession>
    <name>D4D8H5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TRV_03411</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022461.1">
        <property type="nucleotide sequence ID" value="XM_003022415.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C26.956"/>
    <dbReference type="GeneID" id="9581008"/>
    <dbReference type="KEGG" id="tve:TRV_03411"/>
    <dbReference type="HOGENOM" id="CLU_000513_2_0_1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="578"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="1113"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1370"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1841"/>
            <end position="1870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE41843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2248" mass="247854" checksum="4CA658A424374BD5" modified="2010-05-18" version="1">MPAIPSSPELKGPSREPPFPSSPSTGGVVAYNNELHGLRTTTSGAIFSPASMQLGSKKGRPVGLELEDGTVYRGFNFGAERSIAGELVFQTGMVGYPESLTDPSYRGQILVITFPLVGNYGVPSRDKMDELLKGLPKHFESNQIHVAGLVVASYCGEAFSHFLAESSLGEWLKEQNVPAIYGVDTRALTKRIREKGSMLGRMLLRKETSVSHDSAVEQQPENWRENYEVLDWEDPNKRNLVDDDVGLKYNQLRCLLSRGVEVLVVPWNYDFPNLAGKEYDGLFLSNGPGDPATLASTVSHLKIALKENKTPIFGICLGHQLLARAAGASTLKMKFGNRGHNIPCTSMLSGRCYITSQNHGYAVDSKTLPEGWEELFVNANDASNEGIRHASRPLFSVQFHPESTPGPRDTEFLFDVFINTVKECLESKDALSKPVNFPGGTIKENTAAHPRVHVKKVLILGSGGLSIGQAGEFDYSGSQAIKALNEEGIYTVLINPNIATIQTSKGLADKVYFLPVNAEFVRKVIKRERPDAIYVTFGGQTALQVGIQLKDEFEELGVKVLGTPIDTIITTEDRELFARSMEVIGEKCAKSASASNLEEAMEAVRGIGFPVIVRAAYALGGLGSGFAENDDQLRDLCTKAFAASPQVLIERSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSREYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLNEISNSVTKVTCACFEPSLDYVVVKIPRWDLKKFTRVSTQLGSSMKSVGEVMSIGRTFEEAIQKAIRAIDFHNLGFNETSALMSIKNELQTPSDQRLFAIANAMHSGYTVDEIWELTKIDKWFLRKLEGLSLFGKQMSSYNATTVPIPLIRQAKQLGFSDRQLARFLSSNELAVRRMRVEAGIIPFVKQIDTVAAEFPAFTNYLYLTYNGSENDVAFDDQGIMVLGSGVYRIGSSVEFDWCSVRTIRTLRAQGHKTVMVNYNPETVSTDYDEADRLYFENITLETVLDIYQLESSSGVAISMGGQTPNNIALPLHRLNVKILGTSPEMIDTAENRYKFSRMLDRIGVDQPAWKELTSIEEATAFCDKVGYPVLVRPSYVLSGAAMNTVYSQDDLANYLDQAAEVSREHPVVITKYIENAKEIEMDAVAKNGVMCGHFISEHVENAGVHSGDATFIVPPQDLDPETVRRIEEATSKIGNALNVTGPFNIQFIAKDNEIKVIECNVRASRSFPFVSKVMGVDLIEMATKAMIGKPFEAYPPVNIPQRYVGIKVPQFSFSRLSGADPVLGVEMASTGEVACFGRDRYEAYLKALISTGFKLPEKNILVSMGSFKDKMEMLPSITKLHKMGFNLFATAGTADFLREHGIPVKYLELLAGDGEDLKSEYSLTQHLANNLIDLYINLPSSNKFRRPANYMSKGYRTRRMAVDYQTPLVTNVKNAKILIEAMSRRYDLSVAPIDFQTSHRTVSLPGLINVAAFVPGIAEKDSADFQEVTKASIAAGFSMIRVLPVGINSFVTDAQALKLAQLNSQKGSYCDFNFSVTATATNADQVDLISSEVGSLFIPFNHLAGNINKVATVTTHFASWPSNKPIITDAKGTDLASILLLASLHNRNVHVMSVTSQEDIKLIALSKEKGLRVTCDVSIYSLFLSQETFPESCHLPTKKAQESLWEHLGTIDVFSVGSLPYETAGKEASPTVGLADALPILLTAVSEGRLTIDDITKRLYENPKRIFELHDQQDTFVEVEVDRPYVFKSQGAWSPFTGKTLRGSIQRVNFQGKTACLDNELLSDAPKGMDMSSHTPAPPQSPSMKEMAPRSPMAMGSIGRRLSFTTTPQARPSPLKKADSLATADELGPPLYATPSTGGTPSLQELLSRSTFRHKHILSVNQFNRSDLHLLFTVAQEMRLGVQRQGVLDILKGRVLCTLFYEPSTRTSASFDTAMQRLGGRTVAIATQHSSAQKGETLQDTIRTLACYSDAVVLRHPEESSASTAAKFSPVPIINGGNGSQEHPTQAFLDLFTIREELGTVSGITVTFTGDLKHGRTVHSLIKLLQFYQVRIQLVSPKALSLPEDIRQQVIGSGQLIVETNELTPEVVARSDVLYCTRVQKERFADQEEYERLKNSFVIDNSIMNQAKSQMVVMHPLPRNAEIDEQVDFDQRAAYFRQFYFASLQTGVFGTLYQFLCHICVTKVLFDFMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8U1</accession>
    <name>D4D8U1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022318.1">
        <property type="nucleotide sequence ID" value="XM_003022272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8U1"/>
    <dbReference type="GeneID" id="9580865"/>
    <dbReference type="KEGG" id="tve:TRV_03529"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_1_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="248"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="567" mass="65222" checksum="55C2314AB110EC58" modified="2010-05-18" version="1">MAIIYITLGGENISGHPINALMIQGRQLHAQWLAEARYSIDLQGAVSEYTERYSLLPPPSSLIIDNFDQIHQDLLPFRTLAPSTLRHLTNSMASSQWNDIATVVVRNGVAEAQPGIIPTHRWMIEGIVQMITPFAQYLPDMDIAFNLNDECRVSVPWDTIQEINHTARKNLSSRDYPMSHVWSKDRSLSWALSRSNDQLVHSHFTDMSRKDTFHTIVSESCPPSSAARTQYQWKHDTLCSDCAELHSMGQFLQDWTLSGDICHQPDLADLHGFFIAPSAFKVSRKLLPVFSQSKVYGFNDILYPSAWNYMEKARYNPSDENPDPCYEDKENTIFWRGTTSEGFSEAGEWQGMARQRLLHLANNNTNPVSVLLPRRTEGIYSYYTFPPSEISQSIGANVSIGIAEDVARCGGKDCSIQRRELGITNRVQFDEHWRHRFLFDLDGAGFSGRFLPFLQSNSLPFRTAIFRQWFDTRIMPWLHFVPQDIRFHDFWSTLGYFAGVRTVDEAGKVTKVLMKPHHREGRIIAREGRKWAEESLRKEDMEIYLFRLLLEWGRLTDDRRDELGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D929</accession>
    <name>D4D929_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_03619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022295.1">
        <property type="nucleotide sequence ID" value="XM_003022249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D929"/>
    <dbReference type="GeneID" id="9576898"/>
    <dbReference type="KEGG" id="tve:TRV_03619"/>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="288"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55738" checksum="C97804BEF1DA0DC5" modified="2010-05-18" version="1">MLGKDAAAIASRSMEPNGAAADQASSVAAAKLNLTAGNAIQTDKGLFAQLSDNPFFTAGFGLAGLGAGLTLAQRGIRHGAILLRRRMLVDVEISIKDDSYPWFLNWMTLYQRSQLTNQAARGQTQTSFMDSLLNKLTPGMRHLSIQTEKIEHANGAMHTHFALIPGPGKHILRYKNAFIFVNRVREAKSRDLQTGRPWETVTLTTLYSQRHIFEDLFKEAHEYAVKTHEGKTVIYNSWGAEWRQFGQPRRKRPLSSVILDAGVKERIVADVKDFFSSGAWYHDRGIPYRRGYLLHGPPGTGKSSFIQALAGELDYDIAVLNLSERGLTDDRLNHLLTIIPARTLVLLEDVDAAFSSRRVQSDEDGYRGANVTFSGLLNALDGVASAEERIIFLTTNHVDRLDEALVRPGRVDMTVRLGEATRYQVSQLWDRFYGDLDESSAYKKEFLDRLAALGIIEDEDGRKRDRAMGTSAAALQGLFLYNKGNMEGAISMIEGLVSRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9A0</accession>
    <name>D4D9A0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022167.1">
        <property type="nucleotide sequence ID" value="XM_003022121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9A0"/>
    <dbReference type="GeneID" id="9579076"/>
    <dbReference type="KEGG" id="tve:TRV_03691"/>
    <dbReference type="HOGENOM" id="CLU_039854_0_0_1"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="285" mass="31538" checksum="A68C75DEDCBCA247" modified="2010-05-18" version="1" fragment="single">MAPPDVLMVGTGEYTTGFVGGAASTSDKKVGVVGLTMFDLRRRGKVGNLSMAGVSGLKFPHIITDVYSKHGVKGKHLQTNISEVYNGLSTSFESYPADDKVDANAYKAAIDALEPGSAITIFTPDTTHYEIALYAIRRKIHVLITKPATKTLEDHLELLAESRKHNVFVFIEHHKRFDPAYSDARNKARRLGDFNYFYSYMSQPKSQLETFKAWAGKDSDISYYLNSHHVDICESMVPEYTPVKVSASASKGAAIELGCVEETEDTITLMVEWRKKEEPSKVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9H5</accession>
    <name>D4D9H5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000193">
        <property type="protein sequence ID" value="EFE41505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022123.1">
        <property type="nucleotide sequence ID" value="XM_003022077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9H5"/>
    <dbReference type="GeneID" id="9579008"/>
    <dbReference type="KEGG" id="tve:TRV_03768"/>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="228"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="688" mass="73926" checksum="D36613BA698708C5" modified="2010-05-18" version="1">MSEKKDHASSSQMQKRGGSNSFSRLENSSPFSRIDSTAEAVGEAMQVVAEDPLSSPGHGLVEEPEDVFEKKAPEGSQGEGESAEPAAGQPPAELPEQFAELPIELVSLTDSTPPSIDTLSGLFQDFYVRAGSHISTHVSTLASRLHRNSSASSLQSQASRSSRRPTSSHGTQKDTPEQQMLTAEEVAEKRKARKLLQFKQHALEEAVERRACETIYDKIWRHRSTIDDVRDEKLRSKTAALLVMGIELKDLGVDISKQGAEETVDPKECVAAARQCLIRMNDERYPLGKLQQLVAAHKAIVDALTNILPSSSSADEILPTLIYTLILSPPEGVNIISNLNFIQRFRSSSKIDGETAYCLTNLEAAIDFLENVDLTNLRMEEGRAPIDQPDLNLLHPAPMDSNSDEALEKSPSTVSNTTSTAPSARPTLPTNPSAQQRLSDLFQPPAKALGAANDIVRSTADQGLKSISSTLDNSFAFLFGRLKEVQISQGDNARPGTPIVPKTLDDARKLVQVKAGTVPSDETVSEDGSNIGDRTPTPTPSISSRQPLDDRLAELVGGRRRPGTTKRDSSTNRSDTTASDDTAASSISSSTGSTNQGFGSVRGFGTSLNPLSHFPSMIRGLARAPDPAAATSSTRAKSPGPSSVARGAPGIQKFLDMGNASELKVGDIPELLEDYKRLAAMVRAQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAE7</accession>
    <name>D4DAE7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021763.1">
        <property type="nucleotide sequence ID" value="XM_003021717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAE7"/>
    <dbReference type="GeneID" id="9578643"/>
    <dbReference type="KEGG" id="tve:TRV_04094"/>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="555" mass="61785" checksum="B76BAA70C09A8806" modified="2010-05-18" version="1">MFEFFFPSLLAKGFPFLSSAPWGAEALEKRVYKRAVRTVGDEAHRRSVCLSTKLYLPLYPTSNIIIINIIISNNISNCNNTLTIVSLSWVASNHHVLAMSELPLDGKCSSTSLSTQHTPSSTMTDNRIGSFGTVPTAIFNKAHELRRRCEGRPCSFSRYEFPAWLDKSREAVADLLNADPDNIVLVANGSTASNTIMRNFVWNEDGLDEIIQVSIIFAPLGKMTGYVGELSQGLVRTRQVQLNYPLEDDEVVELFRQGIQASREAGRRPRLGIFDTISSTPAIRLPFERLVALCREEGVMSFVDGAHAAGHMKIDLAALDPDFFVTCCHKWLFIPRGCAALYVAARNQWMVRSTLPLSHGFIPTADIEQGKVDGKLAQALASGKTPFVYNFEFVAPMDNFGYLCIPESIRWRQEVCGGEKAIQTYCVNLARAAGALMASILGTKVLDNKSQSVSACCMTNVLLPLKLDAGNGDETPLPEGWYAVRSKPGVQFRVSDWIMRKMATEYETLMPVFFFQGSWWARGSAQIYLELDDFEWGGRMLKDLCERVGDGEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAJ4</accession>
    <name>D4DAJ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000209">
        <property type="protein sequence ID" value="EFE41125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021743.1">
        <property type="nucleotide sequence ID" value="XM_003021697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAJ4"/>
    <dbReference type="GeneID" id="9576826"/>
    <dbReference type="KEGG" id="tve:TRV_04141"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_3_1"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE41125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="566" mass="60281" checksum="219F19C1E007720C" modified="2010-05-18" version="1">MAKLNIIQAKQDRNARDLPGRLARFCLISHQSWRKYFAEVPRNFFFFLNLRREDEDDEDDEENAEDAGTASLLSEVNAWTSTVMYNHDPTRRIPSVLGVGKDASASEIKRAYYGLAKKFHPDTNKDPGAKDKFAEAQTAYETLSDPEKKKAYDTYGSAAFDQNGGFNPGAASGGPFGGAGGFHGFGGFGSGGGFGGGFTADINFDDIFGAFAKATGRNPRGHGSPFSSVAVGDDIEVQANISFMESAKGTTKEINITPLVTCNSCKGEGLKDGKKRSRCSTCGGTGAQIHVIQGFQMQSTCGACNGTGSSIPRGSECNTCSGGGVVRERRTVKIDIPGGVEDGMRLRVNGEGDAPMAEPGTRTQRGNLYVFIRVAADRRFNRSGSDVLYTAAIPLTTALLGGEVTVPTLDGEAKVRVGTGTGTGDKITLPGMGMRKLGGRRAGNGDLKVEFKVTMPRSLTPNQRTILEVLADEMGDKTAKRIMNVNDMKPDGSSNKASTDKTDNAQKGQGFIKSAWDKLMNHRNPCSSSSSKGSSDSTDKKGPETQSDQHKESDQPNESKKASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB79</accession>
    <name>D4DB79_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021531.1">
        <property type="nucleotide sequence ID" value="XM_003021485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578492"/>
    <dbReference type="KEGG" id="tve:TRV_04378"/>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1470"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1840" mass="203214" checksum="BF2B90F26FB92126" modified="2010-05-18" version="1">MERRVTRSAARLAAGSAASVSESTSPPNPAPQTRKRKAPSRREVARADPEVPPSPQPASRSKRQKLTPARQPASRYSARQSAAMSQPRSPGGSEERPKSVAASSSSSKNRTSRNRKTTRDSSQHVSPPRRQKKRGKRDTDVDMKDGAEERKEKANEKDDEETSPTSDSHEEANQMDTAEDDEHESFRNGIFGSGGHFGLQSTLRALSGMMSGMSSRLRDILSNLKTNEDPSVQLIALQELSDLLLVSNEDNLAGHFSPDPYVHELVNLMQPNDFGEENPEIMLLACRCLANMMEAIRGSAGSVVQGGAVPILCQKLLDIQFIDLAEQALSTLAKISVDFPASIVREGGLTACLTYLDFFPTSTQRTAVTTAANCCRNVPQDSFPVVKDVMPILLNVLSSSDQKVVEQGCLCVCRVVESFRYKPEHLEELIEPDLLRAVLRLLLPGTTNLIGPHIHTYFLRILGIICKSSPRLSVELLKMNIVDTLYQILTGVSPPSDESIGPAKSDTVHIMQALIHRPREQVYETLNIVYELLPAASKGSVVLLDDQLRFTLGGGPLPLSATPKIKAMGEKRLELLRNCQPEIKRFATILLPTLTDVYSSTVNLRVRQKVLLAQLKMVQALDVNIIEEALRSVPYASFLAGILSQKDHISLVALALQCAELLYERLRDIYQYQFHREGVINEIKVLATASVLGKDDKSAEEKTGSVLGSKHHLSHDDGVNRGHDNDSGNEHDIQDDIHDHEDESNDEDDFNGDYPDDPEHHDEHENEHDDASDSEASSIVHPPAQSLDHTLQDLITNGAKHFLELYEESKTAGMHEKAEVVLATLRGLTKKIEDCYKASVVGNRGFKLFSELAAYFDQDAFDSITSYELLNSGIIRVLVDVIENSKGQAGADFLKAFKCSQSPLKHSSERKSAFGAFIHQLQDLLSRTENFEVVTFHHNAFDSRSTLSMLSKQIRLRLVAEEGSNIPKPYKNMMVSIHAIANFKTLDDYLRPRISLSERPRHSRHRDPTFPHLPSGTNPQDPESASRGSDTGSPHLSDFPSYRLPTGRDSSNGTSSRGTNKGRSARPSTLQGSGNGEREGVGRRRSARHQPPPPPMESDDTDGPLECADEPNGSDDEEDDEEGDTLDTIVDDIDDDLSEDDVPDPSAVNMEVASTGKVTARKEDGTRVSTPSQSTPVAKSSTTSLARSSPQSFGRSLSMAGRSFTSYAAAMLAMPQDWHIEFVVNGKPITNDTTIYRAVQCNRSNDNNSPARNVWSTVHTIYFRRAQGPPPPEPTTLTPATSNVSAMVDDVDMPESLNNVPTTASILRLLRALHNLNSQSDDELANDSGVIGIAPEPPSQFINTKLTAKLNRQLEEPLIVASSCLPSWSEDLGRHFAFLFPFETRHLFLQSTSFGYARSMVRWQGAQSNDDGQRERRRDDRAYSGRLQRQKVRISRTRILESAMKVLELYGSSPSVLEIEYFEEVGTGLGPTLEFYSTVSKEFAKRKLKLWRDSDSSGDGEYVDNKLGLFPAPMSQEQVTQEAGKKQLQYFKALGKFVARSMLDSRIIDIGFNPLFFSVGRGAYTKKPPSIGSVKRVDAELANSLKFLKKFADKAAAIKTDSSLSAAEAACAMEQCEVDDTKLADLGLDFTLPGYPHIKLIPNGQNTPITMSNVELYIDRVIDMTLGTGIKAQLDAFAAGFSQVFLYSSLKTFTPDELVMLFGQVDEDWSIEKDLSRPFTDFTLPALMDSIKADHGFNMDSRSVRNLLATLSEFNLQQRRDFLQFVTGSPKLPIGGFKGLTPMFTVVCRPSEPPYTPDDYLPSVMTCVNYLKLPDYSSAEVLLNKLSIAMREGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBE8</accession>
    <name>D4DBE8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000224">
        <property type="protein sequence ID" value="EFE40824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021442.1">
        <property type="nucleotide sequence ID" value="XM_003021396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBE8"/>
    <dbReference type="GeneID" id="9578402"/>
    <dbReference type="KEGG" id="tve:TRV_04448"/>
    <dbReference type="HOGENOM" id="CLU_326237_0_0_1"/>
    <dbReference type="OrthoDB" id="3870679at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="903" mass="99640" checksum="0AD9CC63279B3816" modified="2010-05-18" version="1">MAAAIDIVQRREGRDKPLLKSHKVLPRRRDLVSAYSPACADNDTGGDINNGPAYPPTRTLPLTPPVITLEDQKPLEISHDQDAETHLDPQNTITPSNGVKPLTPDITPPRIVSRSKKRDGQSQRFPSASSRTTSFATAKESLSSDEETERSKPTSLLPSKHGPSLSWRNTAVSHTTTDEAHHDKDVQKPKQDRQLFDTNELQVRKRGEKRSSSGLGHTQSSHQEYSLSRIHHGSLRGRTRNENSSGPSNSVEAFAASTGWRSEGDMENNNSGHVRCISTASTTTIEAIVIDSPPQKKRTLRHTEKNDSLRSVSTPTPSTPSVTKPLQSLPLSQPRLTHKRTRITDENRWSIASDMSGTTTSTAITFTKPRKVEDVIRVVVIPQRRSSLKTTAPPRPVLRSLPPNHRRPSTAPDSAPESSQSSRRHRRTMSESLPSTSSVPNAFKPKIPTRRSSLSAPTSRNTSRAGSMSGNSSRMLVTAVGSENKAVLDSKALPQPPSEFINPQTQNLGSEGTGVLSDLIPKPLRLSTTSMPTPQIVLPPDSPVRDHEDSTRQPTPPAGSSTQFQRSIESLSCSPGPVEISQATAVPFFAHNNKSLLVVEHPLCEARPRPPMISLDHVESPLRYPRAAPKPPGSDPQDVPLIPLKRANTVPSRPRPPLPMQTDSSSGTGGGIARRLSLARRRFSSSNRASTADSIPATDAAKDIRSTTHRVRNRMAGKKLDSKKHPFWRPYGFWQDYDDEGISSRRGSLKSSIFIPKTTTTITAGNDLDSNGYESGQYVSNTLGIPHNRTPFQGPISMIRRVSQRSRFRSKPSRVIKSPSSKTSLSLVSEYRQGKRVRSFRPLHEVQDWIARTRQRREQEKLEARREKLRRAIGGNVIVDYTSVASTMDPESVFSPSRRERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG2</accession>
    <name>D4DBG2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAR2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021388.1">
        <property type="nucleotide sequence ID" value="XM_003021342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG2"/>
    <dbReference type="GeneID" id="9578267"/>
    <dbReference type="KEGG" id="tve:TRV_04462"/>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="460" mass="51598" checksum="4477DA61D74BB221" modified="2010-05-18" version="1">MSESLHPSPTILIDNLPAKTLVGVDLLAFTSAPNFHGIKELPPGVHILYTGTTDSFSLRSGEWFTVPDPNEGEQTGSGVDVRLRHWDNSTELLALVDESNDEGRQHAMQQRANLSRIWAAGGLLSYKSRTHKKDDQEETTDTTLAHGEWNGLSGYITPSVLERILGRAELDSEGRPRWTISSGSSAARDSDKIPGLASRGDTEMRGKLVEDEKELRFLPVDLKNTWPPGAVGRDRTEAARDRSWALGNICEWATNNSRATGRIISEDSLSEGEMQILGEMQITFLTALTLINFSCQEQWMRLLQLIFTCQKAVEERQRFFIEVLRLLKLQLAHNDDVEGGLLEMDGDDGNTVVKKILMKFRRIIYDDLTADISAVKAEFIKLEKWANEEYGWELAKESTVRRGMVELEDGEQVELEVNGAEEEDETGDYAPVIVDLEEAGELEADEVEDVEDIDMLDQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK6</accession>
    <name>D4DBK6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mating-type alpha-pheromone receptor PreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021432.1">
        <property type="nucleotide sequence ID" value="XM_003021386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK6"/>
    <dbReference type="GeneID" id="9578392"/>
    <dbReference type="KEGG" id="tve:TRV_04506"/>
    <dbReference type="HOGENOM" id="CLU_035056_1_1_1"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="40632" checksum="69C6210046A5A628" modified="2010-05-18" version="1">MAPHFDPFQQSVTFLRGDGSSFPISMADFNKFVLYAVRTSIAAASQLGASVVMAVLLALLTAPDKRRSIVFYLNITTLLVNVCRTLSTTIFFTSSWVEIYTYFSGDYSRITTGAYANSVMGTIATGIMVILIELSLLIQTHVLCSTLRDLYRNIVLAWSCLVAAVPIAFRIAFMVANVKAIMSQSSLGKNVWIQSSSNISITVSICYFSLVFLAKLGYAIYTRRLLGMKGFGVMQIIFIMACQTMILPAIMSILQYFIPEFEVNTNILTLLALSLPLTTLWSAAAVRHGHNKNHGSGHHFWGGSSEKSLFDHNKTSGGSFSHPTSTLIGSMPGPEKVKSADHFDRLYPELHDTGNITIERNFSVTSNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBY8</accession>
    <name>D4DBY8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021208.1">
        <property type="nucleotide sequence ID" value="XM_003021162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBY8"/>
    <dbReference type="GeneID" id="9578053"/>
    <dbReference type="KEGG" id="tve:TRV_04640"/>
    <dbReference type="HOGENOM" id="CLU_049344_0_1_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="34212" checksum="EE3AEF433C94703C" modified="2010-05-18" version="1">MFDSPTFDFNSYIKYRPPYSDKLYAEIYQYHESHGGQWNLAHDAGTGAGIVAEELSTKFTTVAASDPSAFYLEQARQRLSPGDKFRFGCYPGEDMSWLPDAGVDMITMAEAIHWAEPQDVVTAASKALKPGGTLAIWHYGVIPIFVGSTDAQDAFNELFDHWSSRIIAGAPESKLANLERAVRVTVLRMAEIEFDKSEWKAGVHRIYWNAYHPTVGKTHQDAFKDVQVQENPDDVVERRIDETILSQYADIDWIRGYMNHLYPDVPADDTEQGMFEKLARIMEGRKLQLSWTVTMILATKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC24</accession>
    <name>D4DC24_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021244.1">
        <property type="nucleotide sequence ID" value="XM_003021198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC24"/>
    <dbReference type="GeneID" id="9578089"/>
    <dbReference type="KEGG" id="tve:TRV_04676"/>
    <dbReference type="HOGENOM" id="CLU_2225114_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="106" mass="12490" checksum="9719E71A7FD08461" modified="2010-05-18" version="1">MTEVSLLTGGIFRYASGSVARDRVGKKRRREVEYQEEEKKKKKKKTAILKTERREERKGRYRDRERSETERRDSMSYYDVDAILTDSQRETAGSGAGYQEEEIDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCD4</accession>
    <name>D4DCD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021114.1">
        <property type="nucleotide sequence ID" value="XM_003021068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCD4"/>
    <dbReference type="GeneID" id="9577956"/>
    <dbReference type="KEGG" id="tve:TRV_04787"/>
    <dbReference type="HOGENOM" id="CLU_039755_3_1_1"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="332" mass="37347" checksum="47E2DA9A8DD5DEAC" modified="2010-05-18" version="1">MAESEFGSQRRVELINKIAAGAGGEIDQPLWPFLWLADIPQLEEISKQPDLITYLAGLAKRLEDSQLLARCKLVHADVCAQLLTFLVSYCLYRDPENLRTYTLPDGLSCASDVKAFRDGSTGRSAWLTNLKRNGCVVTGADDPVEAAHIFPFSMRRLQAPDIVNDTYNPWSVFTVDAWYNAITGPVATETVQNLMCLAPSVHKYHERAYFALEPVEEDTQSHTLTVRFHWLPHMANLHRLKVDTRPSFARGIGCGRRIRLWEVVSGDEIISGTLINITGYDRIPLPDPALLQLQWMLQRIVALAGGAEVFQKSNDDGDDDDYSDYSEVYEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCU9</accession>
    <name>D4DCU9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020960.1">
        <property type="nucleotide sequence ID" value="XM_003020914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCU9"/>
    <dbReference type="GeneID" id="9577812"/>
    <dbReference type="KEGG" id="tve:TRV_04954"/>
    <dbReference type="HOGENOM" id="CLU_021167_0_0_1"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="805" mass="88012" checksum="B71CDF7E2C4A4B8F" modified="2010-05-18" version="1">MADDQEQVTNAVQIQKKMDYGSGPGDLPGMADIAVAQIKASAMFAHPWQQLLGSAPVAINSTGLAFVAATSDTAATIELDPPQGGFKYLHYKSLRANLTECGDMGTKAFLAADGGMLYIHSVASMIPDRVNSIMEIIIDPISAQRMLKGALLSIKKSADDCYDRAKTIDKGFNDWMLYATELYASCVEKESSAEEQLAKTKLQMLAAQNILKADEINVKNQKAATRTFKKQLQMASNVYKKASDSFPNTATPSNPLSGSKHLHAYPHLKGIRLLLPQKADTIQQNRWDLVGQEIVGKLGDTLVTALGQLATAYTENMNYTARAEEAEKMFKDFNKKGNDGSGNGNAPLPTPEPKAKVPLPQNSTDPAYVQIKPAIVYLRVLYSILFKGNGGGINWDEVSTTTGSGSKSLLYTLQMLKNARDQFIEVATDKDPSVKFKQVLQTSIQIATEVYNLGGKGSMNDLPGPDDAKVKKWQQDFNPVYIDANELFAVSKALPGSTSTETVMANPNKQQTQDPQMAQGQAVLEAAKDRLHTTQQAYIASSKAYQEATKALTKDQSDLAAAQNKLLQLNTDEKNLTAIKTILEASIRLIAVVKTRVMDLVTFFNSISSTIEVIVEEVVEEFLRKIQENVANNDPDGELDDLKVGNYNFTDLARTQIYKSAIFMRAYFEIFGEVAKMWSDLSIENIMPGIQLLVGISSDFAGQMGKDPKESRDKVRDSVSKLNSWFEGAKAKIEDLAGKEQEKILGQMDSRIQQVAEDTTKLPPPAPTTAEAINAGAGKVTDAAKSAIEFNAEKNPMAVWVRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD11</accession>
    <name>D4DD11_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020879.1">
        <property type="nucleotide sequence ID" value="XM_003020833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD11"/>
    <dbReference type="GeneID" id="9577710"/>
    <dbReference type="KEGG" id="tve:TRV_05017"/>
    <dbReference type="HOGENOM" id="CLU_068979_5_2_1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="24925" checksum="4C9E5E3D406CC47E" modified="2010-05-18" version="1">MNAKQEKPQEVDIHASVDITEIKMAALDLSLPTVLLIIDNHAAFDKEAYWGKRSNPQYKENVTALINAFRDAHARNPHIEVIHIGHSSTNVKSVLHPYHPDGGPAFYPFTEPIPDELVFWKNVNSALVGTDLEKTLRAKGVRQLLLLGLTAEHCVSTTTRMAANLGVTNAPDGSTDGRVILVEDATASFPCGRFDADTVHGVSVATLREFAEVVQTADVLRDLQPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD13</accession>
    <name>D4DD13_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020881.1">
        <property type="nucleotide sequence ID" value="XM_003020835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD13"/>
    <dbReference type="GeneID" id="9577714"/>
    <dbReference type="KEGG" id="tve:TRV_05019"/>
    <dbReference type="HOGENOM" id="CLU_037437_1_0_1"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="42069" checksum="1F28E3A954095CE6" modified="2010-05-18" version="1">MATTIAWKSHYRALLREASYLPDPVAKRYMAEYITSRYRKFTSAEQQKSMNAAKIARLHTRIKKNMKLLQHANQGYTKSLERVLLMSYGRIGRRKRILLRPFLQSGSGSKTAFSQHWRPSDLLLALLQSQSENSNIGAQKVKRPVRTTDLEPRIPELNALARPLADIRKIHIRQKWYAHVLDKTFPPLPQHDWETLQRLVEGSEPWTPPVRRKGPSQITSVDSTSASEQRYLSTDFLIKGATKDPTFAQYVRGRPHQITRRLMRHMWERICALTPLIQWDSSKNKWWFSWGVRQPPAPIYRQVDPVKGLALFEGVHQKTGRVIISRRQSSKPGEGDKNQKADSENPLEAFQSTTSVPRMLASANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD43</accession>
    <name>D4DD43_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020824.1">
        <property type="nucleotide sequence ID" value="XM_003020778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD43"/>
    <dbReference type="GeneID" id="9577595"/>
    <dbReference type="KEGG" id="tve:TRV_05050"/>
    <dbReference type="HOGENOM" id="CLU_1309825_0_0_1"/>
    <dbReference type="OrthoDB" id="4173700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="185" mass="20447" checksum="F47E76B72122C463" modified="2010-05-18" version="1">MLSSQTTVLLIIVAEVLSFLVLLGLLVVLYRILIVRYKEKKASTPRDIDKELLHPALRINTNVSTSNSPPVIQSTITKPSATAKPTNKPTYTPPEPFQSASAQLQYKYLLSRLHTRPQRTQALRSESVPRHYSSQVPRPVRPIHTTLLPPKKLPVIQESVARGSVNVVSPCSDAVRPATSADQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDD6</accession>
    <name>D4DDD6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000262">
        <property type="protein sequence ID" value="EFE40144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020762.1">
        <property type="nucleotide sequence ID" value="XM_003020716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDD6"/>
    <dbReference type="GeneID" id="9577461"/>
    <dbReference type="KEGG" id="tve:TRV_05145"/>
    <dbReference type="HOGENOM" id="CLU_047725_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35085" checksum="39C342D8534B5993" modified="2010-05-18" version="1">MDKKYAAARLLPPIDASYQPARSVTKIPATSSLEEILEVLERDGGVILTDFVPKETMDKIDEELEPYTKTIPDSDSYDDFIGKKTLVIAGLISKSDTLANILDTNETIDQLLKIILEERYPAVFEGHTEELVIDPLLSISMAFHVGHGSPRQALHRDDMVFSSKHHPNMKINEVDGFSCFIAGSNVTRENGGTMVILGSHKWEHDRRGRPDEVSFLEMERGSAFIFLSTMAHGAGYNTIPGEIRKIMNLVFCRGTLRQEENQFLCNPRSKVLKMSPKMQTLLGFKKPAGTWLGMVDNDDPAKDLPAIYEKIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDP3</accession>
    <name>D4DDP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020656.1">
        <property type="nucleotide sequence ID" value="XM_003020610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDP3"/>
    <dbReference type="GeneID" id="9577355"/>
    <dbReference type="KEGG" id="tve:TRV_05254"/>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="306" mass="34068" checksum="D59069B7B120CAC5" modified="2010-05-18" version="1">MSRFYFGDSDGSDNDLNDDNLPFPKPISRASFLTPDFDATTFLASLSNRHQSLADLQTELRELNEALNKELLDLVNENYQEFLSLGAALKGGQDKVEEIRAGLLGFQRNVQGIKDQFEAKKKEIRECLDEKKRLRSKISVGYELLDVAERIELLETNLMIRPGKDATAKENGAQAEGDDESDGLSDVILGSEADDSDEDGEESENEGGNKARISLRRLEAHIQQYLSVKVMADRIGEKHPFISSHAGRIDAIKSALLLDLSTALKETSKLGSKRDEKISTILRLYDSLGHHDEGQQCLKRLGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDQ1</accession>
    <name>D4DDQ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000268">
        <property type="protein sequence ID" value="EFE40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020640.1">
        <property type="nucleotide sequence ID" value="XM_003020594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDQ1"/>
    <dbReference type="GeneID" id="9577339"/>
    <dbReference type="KEGG" id="tve:TRV_05262"/>
    <dbReference type="HOGENOM" id="CLU_042628_2_2_1"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="207" mass="23839" checksum="A96679D1736A0F45" modified="2010-05-18" version="1" fragment="single">FSVWKDELTIYVPPAGVVPVMTFLRDHTAAEYTQVSDITAVDFPTREYRFEVVYNLLSVRHNSRIRVKTYADEATPVPSITSLYDGALWFEREVYDMFGVFFTGHPDLRRIMTDYGFDGHPLRKDFPLSGYTEIRYDEEKKRIVVEPLELTQAFRNFEGGSSAWEGIGQGIDRKPDNVSITDLISSLNMGFKLPTPKPEEKPEEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY8</accession>
    <name>D4DDY8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000279">
        <property type="protein sequence ID" value="EFE39935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020553.1">
        <property type="nucleotide sequence ID" value="XM_003020507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY8"/>
    <dbReference type="GeneID" id="9577252"/>
    <dbReference type="KEGG" id="tve:TRV_05352"/>
    <dbReference type="HOGENOM" id="CLU_877704_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="34642" checksum="FF36040C23A60C14" modified="2010-05-18" version="1">MEAARGSESPRRSRSRWLCLKGGCSVPRIHAFHAEAKHGARLQKARAADQRRVQRTGAATRSASEIYTEIRELDGVKGPPQMVMSPSTLWALAASTCRTTPISTPISTPTAVSDQKQQTQQMQTKGRGSPGPTRPVAAHLHILGFLFILFSFFFASFLRFFFGFFSLLPFCSKSPPLTISTKSIENIYVACVAVRGLWVSASASCMDGVDEQAEGATEKEEPLLDPSPGRFFGSEAEPDDADEPFGNMVREGLQYGEQGRSGEAGEQIVANQTLRAKFDCKAVIHSSFQLVLMGRTSASRRVCNNVEASETWRADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE21</accession>
    <name>D4DE21_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020491.1">
        <property type="nucleotide sequence ID" value="XM_003020445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE21"/>
    <dbReference type="GeneID" id="9584260"/>
    <dbReference type="KEGG" id="tve:TRV_05385"/>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="348" mass="39694" checksum="5FA8391E99BF6EC0" modified="2010-05-18" version="1" fragment="single">SFAHHPSKKPRHIGGAWSDHADSTGNSEERRGLMSGSGFEDDGDAVIEMDLLPPRWMDVQDEVTDYLRDIAQKSAKLDKLHQKHVLPGFGDEEVRREEEDMIERLTQDITRGFHDCQRSIQRIEIMAREAREQGSVNKGEDTMARNLQISLAARVQEASAGFRKKQSTYLKSELETLKMQCLLTFVHSSRLMVLILVEIELRGIDGMVSPLERSSSPVQNQYTDPSLIESDADKSYSQSTLQQTAQQQLQVGSNDAAIAQREREINDIAKGIIELSDIFRELQTMIIDQGTMLDRIDFNVERMALDVKGADKELKVVCLYPLHFYENIRKLIDLPRPQITRDEPRNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEL5</accession>
    <name>D4DEL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aryl-alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000300">
        <property type="protein sequence ID" value="EFE39708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020326.1">
        <property type="nucleotide sequence ID" value="XM_003020280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEL5"/>
    <dbReference type="GeneID" id="9584066"/>
    <dbReference type="KEGG" id="tve:TRV_05582"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="617" mass="68653" checksum="7D4D1B013F5D6BB4" modified="2010-05-18" version="1">MSVQDGSRFDFIVVGGGTAGNIVAARPAESRNVRVLIVEAGIGDSIDNEDIRTPAMAMDLRGTKYDWGFKTTMVKRDDYERIEKPNTRGKALGGSSCLNYFSWVPGSKGTFDMWEEYGGKEWTWDPLVPYLRKSVTYYDDEGLFPPELKCIGAGGPIPVSHAELLPEMKEFRERLVQAWKSTGEPVTEDIFNGEMRGLTHSVNTIYKGRRCGSFLALVGKPNITVLSEVFSKCLIVDCADRCAKGVTVINGCGQEMSFYATREVIVSQGVFETPKLLMLSGIGPAAELARHNIKLIVDSPHVGQHLLDHPGVPFALRVKDSFSMDSQVLRSGRCQDEARDEYTKEQSGPMASPFLEMIGFPRIDSYLEKSPEYCAAKAANGGRDPFCPYGQPHFELDFIPLFGSAFQWHFPHPRKGSYMTVMVDLVRPVSEGGEVTLNSTDPLEQANINLNYFNNDLDIIAIREGIRYAYDVLMHGDGFKDIVEDEYPWEMPLDDDEAMKRTVLDRSQTSFHPCGTARLSKSIEQGVVDPRLRVHGIKNLRVIDASVIPVIPDCRIQNSVYMVAEKGADAIKCDHRDLYCKGVTGIVGHYNRRVDIHIALHNTKASPSISETGENLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEN7</accession>
    <name>CARP_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable vacuolar protease A</fullName>
            <ecNumber>3.4.23.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aspartic endopeptidase PEP2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Aspartic protease PEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PEP2</name>
        <name type="ORF">TRV_05606</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.</text>
            <dbReference type="EC" id="3.4.23.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.25"/>
    <dbReference type="EMBL" id="ACYE01000304">
        <property type="protein sequence ID" value="EFE39677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020295.1">
        <property type="nucleotide sequence ID" value="XM_003020249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEN7"/>
    <dbReference type="SMR" id="D4DEN7"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GlyCosmos" id="D4DEN7">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9584044"/>
    <dbReference type="KEGG" id="tve:TRV_05606"/>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397696" description="Activation peptide" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397697" description="Probable vacuolar protease A">
        <location>
            <begin position="73"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="87"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="400" mass="43361" checksum="C2A8835A76655749" modified="2010-05-18" version="1" precursor="true">MKGSLLLAGATLLGCTSAKLHSLKLKKVSLKEQLEHADIDVQIKSLGQKYMGIRPEQHEQQMFKEQTPIEAESGHNVLIDNFLNAQYFSEISIGTPPQTFKVVLDTGSSNLWVPGKDCSSIACFLHSTYDSSASSTYSKNGTKFAIRYGSGSLEGFVSQDSVKIGDMTIKNQLFAEATSEPGLAFAFGRFDGIMGMGFSSISVNGITPPFYNMIDQGLIDEPVFSFYLGDTNKEGDQSVVTFGGSDTKHFTGDMTTIPLRRKAYWEVDFDAISLGEDTAALENTGIILDTGTSLIALPTTLAEMINTQIGATKSWNGQYTLDCAKRDSLPDVTFTVSGHNFTIGPHDYTLEVSGTCISSFMGMDFPEPVGPLAILGDSFLRRYYSVYDLGKGTVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF02</accession>
    <name>D4DF02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000318">
        <property type="protein sequence ID" value="EFE39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020192.1">
        <property type="nucleotide sequence ID" value="XM_003020146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF02"/>
    <dbReference type="GeneID" id="9583962"/>
    <dbReference type="KEGG" id="tve:TRV_05743"/>
    <dbReference type="HOGENOM" id="CLU_027163_0_0_1"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35922" checksum="549E7FA78A0EB2D9" modified="2010-05-18" version="1" fragment="single">SQSQSFPVPPGDAHVASHHYSPKAKDFAFDRESRREKDIEQGEGELSERTRSYTHYTQESRWKTFTRSVPQVREPTHQQNKIVDADWLNRNFGDYSDPWQGYIDEKADESARHSATFIQRRKIWMKRVQYKILHSPMVPLIIRLTVFIFSAIALSLGGSIRHLSTTHSRPQGPSPLMAIIFDAIALVYLVYITYDEYTGKPLGLRSASAKIRLIFLDLVFIVFASANLSLAFASLSDVNGSCSSGDIDLTIHPRNDKICDRQKVLAAVLLVVLVAWLMTFMISALRYVSLPSQIISAPIISAAANVPPYSRVIERVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF50</accession>
    <name>D4DF50_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000332">
        <property type="protein sequence ID" value="EFE39519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020137.1">
        <property type="nucleotide sequence ID" value="XM_003020091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF50"/>
    <dbReference type="GeneID" id="9583911"/>
    <dbReference type="KEGG" id="tve:TRV_05795"/>
    <dbReference type="HOGENOM" id="CLU_615678_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="487" mass="58791" checksum="D460A89B262E1FB3" modified="2010-05-18" version="1">MYRKYYRHADSDTDSEEEFYHRIHRRPREKVVVEEKRRPRSASVANPYRGGDAQIYIDIKNDLQENTKLAPPQVPVGRARSASQRRPVLADALSDLEDDIIRHERRAIRRLEREEPSRRAEIEAEIRLERIRQRERELDEMRKEEDRMRREDRIRREERERIEASKGSGNASAQPQPQTQPQPRQETELEREIRIAKEEEIRSLRRWRKLQEYMEMQEMGRLEKRPERDDHPLTRRDIEKEIQFERLKKMESDELARRKMEDALLIERMKALEKEREEKERERKIREKVQAEIAQKEKDEMERLQKEAKLKASAIEEYKKKEAERLAKQKEEAEKAKKEFNDKVNQLLGSAGFSEDKITAIMQGKSLKEMELVHVEKHVHHGKHRQIEDEEAFVKVHRRYLEPRTLDAFSLIWEFDPNDADYMLIYHSLSQEEQDRLFDHTRKLRGQRTLTASPHNGPVTVEMKVNDKKRDGLYLVRKKQDRRSLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFJ1</accession>
    <name>D4DFJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal membrane protein Pmp47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019973.1">
        <property type="nucleotide sequence ID" value="XM_003019927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFJ1"/>
    <dbReference type="GeneID" id="9584726"/>
    <dbReference type="KEGG" id="tve:TRV_05941"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34946" checksum="40B292EBF2F0C908" modified="2010-05-18" version="1">MSQSQAAATSVAQKPKPAPTIAAQQGDNIAHALAGAGGGILSMILTYPLITLSTRAQVESKRADSSTIEAIRHIIKREGIRGLYSGLESAVFGISVTNFVYYYWYEWTRAAFEKAAARAGRASKKLTTAESMIAGALAGSATVMITNPIWVVNTRMTAQRSSTEGGDKKAKTTIETLKDLLRQEGPAALFAGVLPALILVINPILQYTFFEQLKNIVERRRKMTATDAFYLGALGKLLATSITYPYITVKSRMHVANKEGPKESLNDKFKKIIKEEGWAGLYKGIGPKVSQSVLTAAFLFAFKDVLYDSMVALRRRTIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFL5</accession>
    <name>D4DFL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019997.1">
        <property type="nucleotide sequence ID" value="XM_003019951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFL5"/>
    <dbReference type="GeneID" id="9584750"/>
    <dbReference type="KEGG" id="tve:TRV_05966"/>
    <dbReference type="HOGENOM" id="CLU_044882_0_0_1"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="55334" checksum="EE98291E5682E7C9" modified="2010-05-18" version="1">MASDSGRDRSQTCPHTGGRSGAGDEEENPFISFRRYADKQLSTLLRSVVGLPSAVLPPAKDWLGLNDEALSQTLRARRDTATNNDYGQHHKCRDCNPSDSYPSSRGGYDEQFFGTNPSIAEQHRRYASQSIPASAFDALFDSAWPTDPSLLFRDLAHFHRPFIFDFMSPSTSAGWPISYLMFSPYSPLQLERQRQLCPRYQEHASSPWFGSLASSHEHKDLREPQWREAFEDLLRIENGKAMLDRHPQGERTNESGKSWLAGLIQRGSLGDGWSHVSQPDGEGEYFKFQCITSNDTSPNHEGMSQEKVPSEEGKQFSELDLYDNFLHKVSHGAAVSHTSPLLRAILEERKQQRQELEELQLQWREMFREKEMERAEDHQAIADSARFRGTASQSQTSSQTNENLSPPIVSSVTTTQRRMQPDGSIKTKTIVSKRFADGREENTETEEITRNNRLAVDDGNQAVATQDENKRDTPNGGRDKKGGWFWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN1</accession>
    <name>D4DFN1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD dependent oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020013.1">
        <property type="nucleotide sequence ID" value="XM_003019967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN1"/>
    <dbReference type="GeneID" id="9580182"/>
    <dbReference type="KEGG" id="tve:TRV_05982"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="490" mass="54854" checksum="DFEF30A4A6ACC8DB" modified="2010-05-18" version="1">MTRATPPVRKVAIIGAGACGLVAAKPRYLLAEQCFEQIDIFEQRNHVGGVWNLTPPEGKGQAVTVIPSEDPNTPLEIPFWHRGSKSSKKEAIFLSPLYDGLETNIPHGLMQFSDLSFPDQTQLFPPFEAVLEYLREYSQDVEHLIQFQVQVVDIKPKDTSLGTWAVTRKDLVSGVLQTDVYDAVVIANGHYNVPYVPSIPGISAWKEAYPQGIIHSKLYFDSTPYKDKKVVIVGNSASGLDIGGQINKVCQQPLISSVKSESYFLSGVASDRKEYPPIAEFMPPESHTRAIRFSNGEIIENVDVVLFCTGYLYSFPFLSGLDMPVVSDGGRTLHVYQHLFYIEQPTLVFPGLHQKVIPFVQAENQCAAFARVWSGRLNLPSKKEMYEWENSNVEARGPGKAFHALAYPLDADYLNEMHDWVASAKPRPGLANGGHGKWGIRWGEKERWIRSKFTLIKREYAALGEKRRACLTLEDLGFDFEASKATEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR4</accession>
    <name>D4DFR4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019914.1">
        <property type="nucleotide sequence ID" value="XM_003019868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR4"/>
    <dbReference type="GeneID" id="9584665"/>
    <dbReference type="KEGG" id="tve:TRV_06015"/>
    <dbReference type="HOGENOM" id="CLU_046006_6_1_1"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="213" mass="23970" checksum="BA38888F2619CDB7" modified="2010-05-18" version="1">MGFSHVGLTVPDDKFEETVSFYLAALAPLGFKEHLRPHPKVVGMGVYYPEFWISSNAVPSSSAGVDVPAGSKDVVFGSTHIAFSTGNRELVHAFYDAALKHGGKSNGGPGVRPQYTRFYYAAFVFDPAGNNIETVCLWPAWCHWKYWFGMGVFGRQKTDTGIYLTMEPTEKAVKQARSARQRREKEIKITEKSKENNIKEIHQRRKTYLTETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI5</accession>
    <name>D4DGI5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019660.1">
        <property type="nucleotide sequence ID" value="XM_003019614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI5"/>
    <dbReference type="GeneID" id="9583577"/>
    <dbReference type="KEGG" id="tve:TRV_06289"/>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="394"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="480" mass="52272" checksum="91CEE8535C0064BE" modified="2010-05-18" version="1">MSGTQPVALYAAKVPPGALVPAVPDAAAMFRVTMAAIDPDAVPEYEDEAQASKAPRATLKIIRPPPGLDYDDDDDDEEDDEDEEDDESDDETNGGPSDPARKKKAMLEAALKDMDDGMEEDDDDDEEGETDLAAAISKLVKGKGKAMEDEDDSDSDEDLELDEVVVCTLDPERNCQQTLDFVVGEGERVFFKVTGTHTVYVTGNYVTPLENMYDSEDEDNDEDDEDDYDLSPDEDELAALVGDDDESDELDDMANPRVMEIDTDEEEEVKAQTQAKQSKKEKKGKKRPADDSDEEPNLDDMISKTLKDEPATNGETKSSKKQMKKLKKNNGEAAEAEAAKANTKSDKKVQFAKDLEQGPTPSKTTQTGTLGVKQVQGVTVDDKKLGTGKQVKKGDRIGMRYIGKLENGKVFDSNKSGKPFTCKVGTGEVIKGWDIGIPGMAVGGERRLTIPAHLAYGKKSLPGIPANSKLIFDVKLLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ4</accession>
    <name>D4DGZ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KN homeodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000365">
        <property type="protein sequence ID" value="EFE38879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019524.1">
        <property type="nucleotide sequence ID" value="XM_003019478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ4"/>
    <dbReference type="GeneID" id="9578217"/>
    <dbReference type="KEGG" id="tve:TRV_06449"/>
    <dbReference type="HOGENOM" id="CLU_038392_0_0_1"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KN homeodomain" evidence="5">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="307" mass="34856" checksum="A45FBC797DC7CD30" modified="2010-05-18" version="1">MTVAYSTVLSDHHSEKLPSFRELLPDHLHDEIEGGVFYTQSNQNWRRGSLQDTMPPPTQRADRLPSRLFARDSRFDDVSLRPDRFMGNSTKSSNLQQPHVVESKSSMSASHSHSRPKLTLNEINRSLPPPIPSPSREYFVKVSPNANSNAIYAPLNSRGRNEGELSNYSISSPRSQFSFDSSNFSHSSSPVNMVSSCDCRDQLSYPSSYEQTHACDRTYSRSAFGHFRPASGYCLSECELGDMREKKRRGNLPKPVTDMLRAWLWEHLDHPYPTEEDKQIFMSRTGLTISQVSLHLYSIDTAAFNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH05</accession>
    <name>D4DH05_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF396 doamin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000367">
        <property type="protein sequence ID" value="EFE38860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019505.1">
        <property type="nucleotide sequence ID" value="XM_003019459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH05"/>
    <dbReference type="GeneID" id="9578206"/>
    <dbReference type="KEGG" id="tve:TRV_06460"/>
    <dbReference type="HOGENOM" id="CLU_058268_0_0_1"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28997" checksum="A942F8A1476195DF" modified="2010-05-18" version="1">MWILPLLGYLGVIIGFCFLTLAIGNITSYIPLCNLETNIPPASGLYYLSELVEEHTVLARRLLTRLIYTIITVHALLWLIDGFPFYLTVLSIFSHIVYAGNLRRFPIVKLSDPIFLSSCVLVGLNHWLWFRYFSSPEYNSGGGSAPTSWNRGGWKSSGGGYYYGAAVDTPSFGEIASYFGLCVWLIPFALFVSLSAGENVLPSMGSEYATGSVSSGVSVSGDSTSSSSKIKTKGMAKALVDGVREWVSESGEVMGFWGGQRTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH13</accession>
    <name>D4DH13_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000367">
        <property type="protein sequence ID" value="EFE38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019513.1">
        <property type="nucleotide sequence ID" value="XM_003019467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH13"/>
    <dbReference type="GeneID" id="9578204"/>
    <dbReference type="KEGG" id="tve:TRV_06468"/>
    <dbReference type="HOGENOM" id="CLU_1361299_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="201" mass="22962" checksum="6B3269E9677723AD" modified="2010-05-18" version="1">MLEMKMKMKEREKGERERMKLEMQERREGHGLAWGGQDDGDDDDEGDDKKEEEEEDITETRRGEEMMDKKRDVRDLDYGIQTWLVHPTAVRCLLATKRGETSSGILWLSYNMQTAGDYKTSIQLLSPRSISWTATGIHITGDVGRDYGVQPLSVDSTYKRDTNHGQKKGEDDLLILLSPLPEFLPEFSLSLSLLLVALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH44</accession>
    <name>D4DH44_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000371">
        <property type="protein sequence ID" value="EFE38825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019470.1">
        <property type="nucleotide sequence ID" value="XM_003019424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH44"/>
    <dbReference type="GeneID" id="9577924"/>
    <dbReference type="KEGG" id="tve:TRV_06499"/>
    <dbReference type="HOGENOM" id="CLU_152122_0_0_1"/>
    <dbReference type="OrthoDB" id="10568259at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056269" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="175" mass="18596" checksum="D328F54C040525A4" modified="2010-05-18" version="1">MKFQAVLVFFAGALALAAPIEERDLPVVGTLGLSSLLTWWHFCLYQKSAKGAVSKHRTNLQIVTFADRLFKAGKVAPSAVDNLPAGGLVKGLPLAGGLLGGGAVLKSYLASVISYRTLVGVKQNKHLLTAKTVTYSKSVNGIMSDFAGKVMDSRASLLVIPFFSVYGELLKHSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH90</accession>
    <name>D4DH90_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000374">
        <property type="protein sequence ID" value="EFE38786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019431.1">
        <property type="nucleotide sequence ID" value="XM_003019385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH90"/>
    <dbReference type="GeneID" id="9577879"/>
    <dbReference type="KEGG" id="tve:TRV_06545"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="500"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="707" mass="77465" checksum="7446BC1CFAF8441B" modified="2010-05-18" version="1">MGSIGYQDTGYRRHDPNVMPSLAPSLPRYAPDHVAEENRYEVVIAGAGPAGMLLKLLLSRFGLGEKSVLCIESRDTILRAGQADGIQPRTMEVLKSLGLMHEISTDGCPVWEVAFWNPVQQKGGEGEPNTGSRGIERTAIVDDVALAARYPHEATTHQGKVERILEDDLLRYSGGVRRSTTLLDVQIDEEGDPAFPVIAEIESPTGGRRTIRSKYLVGADGAHSTVRRCMGLKLEGEMTDHIWGVIDLVVDTDFPDVRRQTAVHSDAGSIMIIPRERSMTGAFITRLYVQVPGDVKVDEADIAGTTKAQGFKKGYDDPRARRGQVTVESIMKQAQEAIKPYYIKQREGTKVEWWTAYQIGQRVSDHFLVRDANGKHRVFIVGDACHTHSPKRLYPNMSQAGQGMNVSMMDSFNLAWKLAYSVNGLSPVSHKSASSPDTILDTYETERRTIAQQLIEFDRSFSSMFSGKIGTASAAGSKLTHDQFLEVFRTGNGFTSGCGIEYPESILVDKSIDHNVIRGTDYLAGILRPGRRLLNVKLKRHADGCHVDLHDEIPATGAFRVLCLTSGDLLDPNGMSSQTLTGLCEMVKRVSSMYSSGNILQLITIYPRALVGLTPTSPPKAPLPTSSFVWSDVPSSLHEVAEMNVYCSAVASEDAYQLYGVSEDEGAIAVIRPDGYVGGVACLDETGVDKIGRFLEGCIWLGQEHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHC3</accession>
    <name>D4DHC3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intracellular protein transport protein (Sat1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019412.1">
        <property type="nucleotide sequence ID" value="XM_003019366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHC3"/>
    <dbReference type="GeneID" id="9580128"/>
    <dbReference type="KEGG" id="tve:TRV_06579"/>
    <dbReference type="HOGENOM" id="CLU_005862_0_0_1"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="790" mass="85973" checksum="829111FE0B5DE0DE" modified="2010-05-18" version="1">MLSDIQVFVRWKEQTIFAGEDVECTITFKNVTEEEAGNEVVGTTKHYRGGSRPINTVTDGTNYSPAKSLNPFSFNNPPRRPQSSGYRPRHPHHRASASVGSSPILSQSFPPTTPSRTHGASNTPGHSHKRSVSIISLETDISHDRKQLQSPKSPQPGRHSNLSLPSTKDEADPSRYPINNSPAARRSPMRRAPRKMSAFHGDFKFPQAPPSPENKTNPSTQPAPEGQYTEPPTKATIPDHINVTAANGKLTADQPRCLTPATKLSAVSAMEGSTRSSTEFYSLSNNSTETLDSDYKLASMNRGLPRHRRHQSNLEPTRNGRSNESQTLLMGYAQINASFTVDGSLLDQSIFEEVKRKGVVGHHGSNERSPRQSKPRSGFWGNIGLSSLGNSLASLTSTGELDGLREMRGASSSNSIPLLSTPQSLLFVDLRLAPGQEKTFSFSFTLPRGLPSSHKGKAIKISYNLVIGTQKAAAIKGNQRLHKINVPFRVLSGVDAQGGVLGHDLMQPYVVLRDEARVQSIDSSAPRPPAKEKSISAKAWTSAPQFLSYVDEILKQKDRQDSLVSPISPGPPHLHHEAPFSCKDAIDLAILRSNQSTASDQSVNRFEISRSGRRVAVIVLNRPSHRIGETIVATADFTNAAIHCHSLRGSLETHETINPEIALRSAASITRATRKVHAMCFENTLFASRVAFTPAIPVSATPTLITSGVNVEWQLRFEFVTSSLPDSTENAHTSASGIGLLEPVEHDERGTVFAAAEHISCESFEVSIPITVYGGTVQEPSREELQGIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHL2</accession>
    <name>D4DHL2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019324.1">
        <property type="nucleotide sequence ID" value="XM_003019278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHL2"/>
    <dbReference type="GeneID" id="9577646"/>
    <dbReference type="KEGG" id="tve:TRV_06668"/>
    <dbReference type="HOGENOM" id="CLU_057145_0_0_1"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055579" description="Aminoglycoside phosphotransferase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="32479" checksum="76AE5F903CB2C5BA" modified="2010-05-18" version="1">MFTAAITIVVGWLLWFLPASFIQRAPQDWLISISHRLKHSRKINDSNWGDPVVRITRNIVAKYGPGVSPGEAATQEYAYQHLDPKIVQVPRVYRYCQHRESLDAKLNGYLFMEYIPGQNLKTRNNIGSDSEITRKLIKIIAHLGQIAGGSVPGPVGGGIPRGTLWGDGGAKREFRSLEDVNDWVNKRIEPIDETVDLTPYPLVLCHMDLCRRNMVLKKDESICLLDWGYAGFYPRFYEMAAIRCGNDHYNTPLFEATSKAIPLTEEELRCMDLVIRAPDASFQWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI10</accession>
    <name>D4DI10_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019133.1">
        <property type="nucleotide sequence ID" value="XM_003019087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI10"/>
    <dbReference type="GeneID" id="9580079"/>
    <dbReference type="KEGG" id="tve:TRV_06817"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="4170567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="51"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="45986" checksum="BCD4775E0FB03509" modified="2010-05-18" version="1">MASPASPARKFISSGLRELDPTQKIEEERFGDYVAERYYPVNIGEIFCSRYQIITKLGFGATSTIWLCRDLREHRYLTMKVNVRSKRPNPEVELTNYMKSIEDIHGGEVHVRRVLDSFSIDGPHGTHCCILYEPTGIDLSDFIHRLETGALPQVMLRPAVRYILIALDYIHQLGIIHTDDQSVLSQLEQDELQHPIPRKQTPSRTIYLTREMPITKGFPILSDMGEARRAETKQRGLIQPSIYRAPEVMLDMEWDNKVDIWGLAQTIWTIFEQRHLFDNINPMGELDHGRRFAEMISLMGPPPLEFLKKSKESLKYWDENGDINLQLLNLCSNWKLSHMYPIPKQSLESSEIQLKGDEKKQFLEFMRKMLQWVPEDRADAQHLLFEDPWVRGGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIC3</accession>
    <name>D4DIC3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019030.1">
        <property type="nucleotide sequence ID" value="XM_003018984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIC3"/>
    <dbReference type="GeneID" id="9582435"/>
    <dbReference type="KEGG" id="tve:TRV_06931"/>
    <dbReference type="HOGENOM" id="CLU_010595_2_4_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="150" mass="17064" checksum="B327BE705017461F" modified="2010-05-18" version="1">MGFIGDHDRFMAQAYENLNPGGWLEMQTTDPTLFSVDGGMERAKILPSYIANLHRASAMFGKSMTEVDTWPSRMLPIGTWPKDPKLKEIGKFQQVQVTQAVGAYTPALYTRVLKWTREEVNDLCAKVRAELQDRSLHLYLKVHIVIGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIJ0</accession>
    <name>D4DIJ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018987.1">
        <property type="nucleotide sequence ID" value="XM_003018941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIJ0"/>
    <dbReference type="GeneID" id="9582311"/>
    <dbReference type="KEGG" id="tve:TRV_07000"/>
    <dbReference type="HOGENOM" id="CLU_040671_0_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="43922" checksum="873F76EEE4EC319F" modified="2010-05-18" version="1">MENNLAGTGAPPAPSAAATASAAGQSQFPAHENPRVWLFSSGDSPIGISLARQILAHGDYVVCGRCPADSERENPRVTAFENFLEELENAEPGQEISGWKERFDVVNLDIRIMSDCQAAIASTINKYGRIDIVLCCTSQAVIGSVEELATSERARMLLKDQFETNYFGPVNLIKSALPQMRLQRSGHLMVLGGITGRIGTPGLGVYCAAEWALDGYCDSLAYEVAPFNIRITILQSSVEIGVLSNLITSVPPLDAYNPAQNHAPLFRRIMNSVLSQLPGFSGYARSAHFPPSTQAPLSSPGSVKQESTKENDEPLSAPSGVSLYPPLGSEHLEMLMGETMYAVTAIGGHENPPARHIVGAESVACVKEKLKTVSEELEDFIECSCAVDINSTENPSRVTSDEVVVQPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIK2</accession>
    <name>D4DIK2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate/L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018999.1">
        <property type="nucleotide sequence ID" value="XM_003018953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIK2"/>
    <dbReference type="GeneID" id="9582323"/>
    <dbReference type="KEGG" id="tve:TRV_07012"/>
    <dbReference type="HOGENOM" id="CLU_040452_2_0_1"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38037" checksum="9D79B28B3418FCA2" modified="2010-05-18" version="1">MADQEKKRVAAPDAEDFVQRVLEKNGVPSANASIVAKCLVEADLRGVDTHGINRIPSYMERIRQGVLDPKASPSLTQVTPVVARVDGNNAFGFISATMAMDRAIEMAKEFGIGMVSVHNSNHFGMSASFVRQAVDANMMSLVFTNSSPALPVWGGKEKLMGTSPIACGAPSGPNSPPFILDMAQSVAARGKIYKAHRRGETIPEGWALDANGSHTTDPAAALRGVMLPIGGPKGSALSIMMDVFSGVLSGSSFAGHVTGPYDPSKPAGVGHFIMALKPDLFLSLDEFKDRMDYLYKRVVTCEKMQGVDRIYYPGEIEIITSQERAKDGIPYVQAEIDALNKEADLVGTGHIVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ49</accession>
    <name>D4DJ49_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018779.1">
        <property type="nucleotide sequence ID" value="XM_003018733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ49"/>
    <dbReference type="GeneID" id="9581175"/>
    <dbReference type="KEGG" id="tve:TRV_07214"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55902" checksum="E37066ADB6339296" modified="2010-05-18" version="1">MASNLTTSILPHTIVLDYAQAVLETDQWLRAAKSHISTHPSAVSLAIISGIVIYVIWSSTARYLRLSAFHGPPWAAFTRLWLCKTIASGESASRFINVNQQYGPVARIGPNHLLTDDPEFIRKILAARSHYTRGPWFDSIRIDLEVPNIVSERHPGRHNHLRHQMSGAYAGRDVEGLEDMIDERIQDFVDVIERKWLSDDNGTNAFDIAKRVQFLAVDMITHICFGKPMGFVKTDSDVSNFLKTIESQLPIVQHFSVIIEINDLLHWLVGLPFMRRLIVPSSQDKSGIGIIMGITRNEVEKRQQSKSEPKKDMLTSFMKHGLSPSEAETELIISLATLLAVASNPRVYARLTKEIDEAEASGKISSPIRDQEARRLPYLQACIKEGLRCFPPVAQLRERMVPAGGDTYNGQHIPEGTFIGLNTWGVQLNPVFGNDPRVFRPERWLIHDEARLQEMSRVQELIFGHGTTRCLGIPIAMMNLNKVFPEVCPISISRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ91</accession>
    <name>D4DJ91_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GATA transcription factor (AreB), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000428">
        <property type="protein sequence ID" value="EFE38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018712.1">
        <property type="nucleotide sequence ID" value="XM_003018666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ91"/>
    <dbReference type="GeneID" id="9581042"/>
    <dbReference type="KEGG" id="tve:TRV_07257"/>
    <dbReference type="HOGENOM" id="CLU_035349_2_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="232" mass="25499" checksum="845629487CA2BD72" modified="2010-05-18" version="1">MATALANQGHVQLQSVCQNCGTSKTPLWRRDEMGSANTDANNQATPRSDGTTPYGYARASRKLSPGRSDGSNSPVSRTDTPNFHGSTSIPSHNMFDNVGLSDPNFNPSGNFASLQLQHPSPGSTSSNERHLEGPQTYENLVAANTSLKTRVNELELINDLFQDSESRLRQSLKEAQKREEELKRRISELEGRLSGQEQAQSKDEPVEPQTKRCRLSDSPEKVEVDNKSSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJC0</accession>
    <name>D4DJC0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000433">
        <property type="protein sequence ID" value="EFE38053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018698.1">
        <property type="nucleotide sequence ID" value="XM_003018652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJC0"/>
    <dbReference type="GeneID" id="9580849"/>
    <dbReference type="KEGG" id="tve:TRV_07286"/>
    <dbReference type="HOGENOM" id="CLU_032674_1_1_1"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="389" mass="43106" checksum="795F5325870815F1" modified="2010-05-18" version="1">MATEDNAVSGLTMADRVQKIRSRLSALFAGGSPGSCNIENSHKPSRLSPAEIRMYAPGSGGSVRRERNISSGRRSISSTGSVIDNNAPPNDNILPFSPPSTESGGHMTNSRAQHRVENHIHRGGVLLNWIQRSVEAHPHQPKHKPSRSKLAGWLLCMRPRAKARSTRRKLIDCAISGILLASVLTTCSSPSIPCFLCSIHILTICLDLVLAVTSSGKKFEFHIILIIALMACTVYFCHSLIRLLMTAKRRQVRRRRVHYNQPTRDPDMVESFTHIDRPIPVIFATDLEMGLGTEAEEGENKPGQISIPPPAYGLWRGSVKMDPSRLYWQRIDPQKPNRRHSQSMGEPRPPSTNRPPSYILDESQPSIVVNLQPQLQSTSTSSTTVPTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJD4</accession>
    <name>D4DJD4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000434">
        <property type="protein sequence ID" value="EFE38049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018694.1">
        <property type="nucleotide sequence ID" value="XM_003018648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJD4"/>
    <dbReference type="GeneID" id="9580847"/>
    <dbReference type="KEGG" id="tve:TRV_07300"/>
    <dbReference type="HOGENOM" id="CLU_1639534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="162" mass="18014" checksum="DDE34AB5924ECFA0" modified="2010-05-18" version="1" fragment="single">MTSNGSQVAADDHQRRRRKEALRQRKNNKGPISSRLMLDIRLKGEVGVISDELLVDLFPRRGSHDVELFPEIIYVALAPWVPNFTTVEDVQWTIVPVHTQASEKAKASFISGAAIHFPVAASSIQPFIQVLQGSDPSRSSFLLAQRGIEIHIVDVTPLHLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI1</accession>
    <name>D4DJI1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018659.1">
        <property type="nucleotide sequence ID" value="XM_003018613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI1"/>
    <dbReference type="GeneID" id="9580812"/>
    <dbReference type="KEGG" id="tve:TRV_07349"/>
    <dbReference type="HOGENOM" id="CLU_2721727_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055924" evidence="2">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="72" mass="8323" checksum="1F404E11DA9593E8" modified="2010-05-18" version="1">MTAADATLARSFRLFCFLLVFLFATKKVAVERMDHVMSLVLTSSKAKKAGEEKAEQNKRERREEKEEAEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJX0</accession>
    <name>D4DJX0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018499.1">
        <property type="nucleotide sequence ID" value="XM_003018453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJX0"/>
    <dbReference type="GeneID" id="9584428"/>
    <dbReference type="KEGG" id="tve:TRV_07513"/>
    <dbReference type="HOGENOM" id="CLU_039863_0_0_1"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40733" checksum="D738CFC4FE01E698" modified="2010-05-18" version="1">MVAFLSRLLESTPHEKVLHRIHTNAAAVSVIKANALADEKTEAHVEDEVADELNISLDSLLKVLARYDFPPSACSHIRGQEQIFGSRIGRDDKKNKVTAYDFWYAIRARAYIRAVDKEADLKMTIVTHYDVKSQSSVILLKHRSFNDLPKALKDELHDKLVDFILNPSTAALAGNPFALHLLHFNSTIQYYRRAARDPRDSVRKEEIKAHGGSSGLEEINIQRLHLTLTSLDQDKLQLNFILGVLARLRKQHDQFYRMVKGASDVDSRDWLYTRVEEEYDRFENQITYFKTSIEDVAARAQRLLDLLFNLSTRHSTHFSSRMAEEAMKESASMSTIAIMTMVFLPGTFVAVRFTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK64</accession>
    <name>D4DK64_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018391.1">
        <property type="nucleotide sequence ID" value="XM_003018345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK64"/>
    <dbReference type="GeneID" id="9584335"/>
    <dbReference type="KEGG" id="tve:TRV_07585"/>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056567" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="402"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="521" mass="58014" checksum="8B5BBF43DBF0C6BE" modified="2010-05-18" version="1">MIVRFRTVAFLLAVISSANGLKPSDIPPDTPVSSLLSSAKTHLASGSPEDALLYFNAAIDKDPSNYLSIFQRGAAYLSLGRHSRAADDFNKVLKLKPGFEGALLQRGKLRMRSGNWTGAKEDLQAAGKPGEGDLVQLHEAHVAAVAAEEAEKKQDWETCVAQSNIAITKAMGSPELRRTRGKCHFERGDIQEGINDLTRLTQLSPNNVDPHLQVSAMLFYSLADTERGMDQIRKCLHSDPDSKICSRLFRGEKRNSKQLKNLDKLLETRKFHKAAELLVGTKGETGLLEDIQQDVKSAQEDGYIHPKAPNNLYHSLVEKTCETYRAMNSKRKARPYCSQCLEFNPSSLHGLLSKAEEQIDAEQYEAATQTLKTADEHHSGSQEIHTLMQKAQTLLKRSKQKDYYKVLGVDRDADEATIKRAYRKLTKKFHPDKARSQGIPKEEAEKKMASINEAYEVLSDPELRRRFGHGDDPNDPHGGQPHFNPFAGGHGGSPFFFQQGAGNHHFKFTQGGFDFQGGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK88</accession>
    <name>D4DK88_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018373.1">
        <property type="nucleotide sequence ID" value="XM_003018327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK88"/>
    <dbReference type="GeneID" id="9584306"/>
    <dbReference type="KEGG" id="tve:TRV_07609"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="36739" checksum="0DC50F0E715E83A0" modified="2010-05-18" version="1">MSSCEGVDFINNDDVTWQYCPTFAPAVLFAVLFFLTTGSHIMQAFTFKKTFSWVIIVGGAWEAIAYGLRAAGAKNIYQKGFGLPHHILIALAPLWINAYVYMVLGRMVHFFLPDKRCFGISARRLTVIFVCLDIFAFLTQGASTSLLNSDSASSIKIGINLCTFTSLTLQTSQFPNMSIDMGGIGLQELFILIFIGLAVRFQYKMAIVEQTEHSNGPWRPLLYTVYATLVLITIRIIYRLVEYSGGLHSAIATNEAAFYILDATPMFLALFALNIFHPGRFLVGPGSEFEKKPKKAKKRKNKNKSGSGKWILDDDGQGHFEELPLDERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK93</accession>
    <name>D4DK93_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018378.1">
        <property type="nucleotide sequence ID" value="XM_003018332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK93"/>
    <dbReference type="GeneID" id="9584300"/>
    <dbReference type="KEGG" id="tve:TRV_07614"/>
    <dbReference type="HOGENOM" id="CLU_1179957_0_0_1"/>
    <dbReference type="OrthoDB" id="5279705at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="26677" checksum="FADD523186110487" modified="2010-05-18" version="1">MFAFPQPAIPQPLPRPFGQFGTTLAYSMSDQNTPLSPENRGHSGTNQLDSTPFTFSLSSPPHPGSTRTSNSRFAQRYASSIARPAARVAERQSRESRRDSFLNKVKRSRQSDKFEARSDQIQRSDFLEQRKRFEEEMAKSGPQLDNIEEDEGDDYVDAYPQEEDKDIDESLLEDFIAQEENEYMTLAEDMPDTCAAEEPLNSDILYGDMEEDGLLVDLIDQIESQSHQQMDMSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKG4</accession>
    <name>D4DKG4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018307.1">
        <property type="nucleotide sequence ID" value="XM_003018261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKG4"/>
    <dbReference type="GeneID" id="9580003"/>
    <dbReference type="KEGG" id="tve:TRV_07686"/>
    <dbReference type="HOGENOM" id="CLU_039675_1_0_1"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="203"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="41075" checksum="F19E3D182AC6330B" modified="2010-05-18" version="1">MDFASLMSKEISKAKSDAAEKKYTKRSDIEAARVAAYNAEQEKLQREREERAELKRRRDEEEAEQNRRREEKRRRLAEESRARREAEEEAREKERRKRLGLAEDESSSEKDGTTIQDGEDLDDDELVGKLRELGEPARLFGESHKGRLRRYRNLVNPEQNRKKLTDGPIPTTLELVPEADMKVPDKLPADEEGKRYLFRQLASYFTLVLKEWEIALAQRDDSVKQTFQGKQAYNAMVQSRENMRPLFKKFENGDIEDGILEPVVEIVRNAQNRRYVDANDGYLTLSIGKAAWPIGVTMVGIHERSAREKLHEGGKGQAHIMSDEITRKFLQSIKRCLTFAQVRWPPDDQLQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKT9</accession>
    <name>D4DKT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G2/M phase checkpoint control protein Sum2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000483">
        <property type="protein sequence ID" value="EFE37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018177.1">
        <property type="nucleotide sequence ID" value="XM_003018131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKT9"/>
    <dbReference type="GeneID" id="9579547"/>
    <dbReference type="KEGG" id="tve:TRV_07813"/>
    <dbReference type="HOGENOM" id="CLU_019221_4_0_1"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="61389" checksum="D6AB99EC53C675F1" modified="2010-05-18" version="1">MDMNNFIGYVGTLHDINPEASTIALENVVSHGTEGRRGNASDEVPPTSCVYEYIVFRGSDVKDINFADNEKENQPPEQPQVPNDPAILGTTAPPRQAQAPAAAPAPAQAGRGQPAQVPQQPSRQQPPPPGYPQQPPYPNYYNPYGQQFRGPPGGPPGFPGAPGPGPGFPNMPYGQQGWYPPPGQGFPQQPGPFGPPQMPIGPPRGPPGQQQQQPPQQQPQSQQHGPEGAPASQSTQMPTSELPGGEKAPKKSTTPAPAAAAQKESQKPTQPKPEASTAQTQKPAPAKAPTQTISEATVVAKNERIVPAVPVAVPLKPAAQSTASASQQGNRAPPNAMEEATRAATAAVAAAMAKLPQPAGSQQQQQQQQPTNGSLESVTKKINEMRPFDGERQPRGGHRGRGGHRGHHHHHQQVKKIEVPSTDYDFASANAKFNKQDLVKEAIASGSPLLEAEGKAHSATSEANGVEGGDFSSAASGHATTAVYDKTSSFFDNLSSEMRDREENARNKTSGREWRGEEEKKNMETFGQGSVDSGYRGRGRGRGRGYGGRGRGYNRGYGGGRGRGGFRSGRVAAESTGVPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKW1</accession>
    <name>D4DKW1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018139.1">
        <property type="nucleotide sequence ID" value="XM_003018093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKW1"/>
    <dbReference type="GeneID" id="9579348"/>
    <dbReference type="KEGG" id="tve:TRV_07835"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="116"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="53208" checksum="B97120D1952F8E9F" modified="2010-05-18" version="1">MSAPAKSRWADDNPETEAELQRRKQEKEAKKRAKAERQRLIAERQQQQEQQQQQQTQQSTEPSDKQPDKPENGSEPPTKRRRLSNETPEDAGAAPPARLLQFPAPEWGPCRHIDNFENLNAIEEGSYGWVSRARETATGQIVAIKKLKMENAYDGFPVTGLREIQTLLASRHPHVIQLREVVMGDAMDDVFLVMDFIEHDLKSLLDEMREPFLPSETKTVLLQVLGAAEFLHSHWIMHRDLKTSNLLMNNRGEIKLADFGMARYYGDPPPKLTQLVVTLWYRAPELLLGADKYGTEIDMWSIGCIFGELLTKEPLLRGKNEVAQLSEIFALTGPPTSQTWPGFRSLPNAKSLRLPPSSSDPSGPAVPLLPRSKFPYLTSAGLSLLSHLLALNPAARPTAKSCLSHPYFREDPKPKPKEMFPTFPSKANLEKRRKRDTPEAPKRGEEAPRLDFANVFGGGDSGPTEAGAGFSLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL52</accession>
    <name>D4DL52_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">XTP/dITP diphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018090.1">
        <property type="nucleotide sequence ID" value="XM_003018044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL52"/>
    <dbReference type="GeneID" id="9579299"/>
    <dbReference type="KEGG" id="tve:TRV_07926"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_2_1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="137" mass="14934" checksum="65B8F31DBCA26B59" modified="2010-05-18" version="1">MKSINFVTGNKNKLAEVQAILQGTIEVESVSVDVPELQGTIEDIAREKCRKAAEAVNGPALTDDTALEFNALNGLPGPYIKWFLEKLGHVGLNKLVEPYEDKSAVTVATFAFCAGPGQEPILFQGRTEVSEIYKDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL77</accession>
    <name>D4DL77_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin (Or S-antigen), N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000494">
        <property type="protein sequence ID" value="EFE37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018040.1">
        <property type="nucleotide sequence ID" value="XM_003017994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL77"/>
    <dbReference type="GeneID" id="9579169"/>
    <dbReference type="KEGG" id="tve:TRV_07951"/>
    <dbReference type="HOGENOM" id="CLU_032323_0_0_1"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="513" mass="55782" checksum="3813A3CCF5F18E48" modified="2010-05-18" version="1" fragment="single">MAASLASRAAPFEPWTKRSSLRVDITLKDQPASGICSYTTLDAIEGEATFTADVDTRFEQISISFVGTSRTLIERPGAAGPTVGRSSAFHTFLRLVQPIDESDYPEPRILEAGRKYTFPFTFVVPERMLPQSCSHKMNHPQVQLAHTNLPPSAGDPMLAGDGNSLLDDMVPQMVQIQYNVRAKLSKHNPSTGTLRTVIDQGKKVRIIPATDVEPPLDVSENSIDYCLRTEKSVKRGALRGKLGRIAMAAAQPKPFHLPPIHHPGSEDVTISEEQETPSTLVKVHVRFDPADENQKPPRLSTLWTKLKVFTYYASEPWKDFATRANMPNWSLNHGMYAETVPLETRCIASVPWTKHSGDANSTFCSPASSSSNLAITTPLSSAPNSRRGSVQSTSSIDSSQTGPTAAYAGNTYYTCTILAPITLPKTKAFLPTFHSCLTSRIYALDMSLSVVPPNTSLTVPQLSIRVPVQVAGAESLAQAVALRGDNVQNTDSFFTPRSISPPPAEYTGRASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLE7</accession>
    <name>D4DLE7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_08021</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017970.1">
        <property type="nucleotide sequence ID" value="XM_003017924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLE7"/>
    <dbReference type="GeneID" id="9579848"/>
    <dbReference type="KEGG" id="tve:TRV_08021"/>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="15">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="361"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE37325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="906" mass="100894" checksum="F6A4B5AA2545FAE5" modified="2010-05-18" version="1">MAPFLRSRVLEHGTFGVSHTRVPTESRPGHVALIAGLYEDVAAVTTGWKLNPVNFDSVFNRSHHTWSWGSPDILPMFSTGAEPGRVEDQMYEAEFEDYSKDATELDYWVFDRVKKLFEDAGTDKELNTRLRQDRIVFFLHLLGLDTTGHAHRPYSQEYLRNIQIVDQGVQEITDIINRFYDDDKTAFIFTADHGMSDWGSHGDGHPDNTRTPLIAWGSGVAKPRTVKSGKAPGHEDGFSSDWQLDHVYRHDVAQADIAALMAYLAGLESPVNSVGELPLSFLDATDEQKAKALLVNAKEILEMYRVKEREKMGEVLHYKPYPGFAETSIENRLASIEELIQEQDYTAAIQQSDDLIKIALQGLRYLQTYAWLFLRTLVTAGYLGWIAFSFTTAVDVYVLDGKIEVQRSPGLIISFVSILVGIYSLLAFQSSPITYYAYAFFPVLLWEEVFARSRALAEGRKKLFSQFSKSDTVKLAINTAACLALLEVMVYTIVYLAATAWPLLYGTDFVKTNFFLCAIWAFSCAAMSVFTLLPANKLENITLISAGGILILLVGFLYIVFEKRLLEQTVLSSDRQSAADVNGVSRVILGLQVGLVAISVFVTRSSVSSLRAKQGLPLGTQVAGWTTLVTSLVIPFAHALRPRKHHLLRQMIIFLALGPLFIILTISYEGLFYFAISITLFNWVQLEHRIYRHSKNDISITSGALSSKTGLEEEISIPRAAKQGEKAAAQGNYRSLVLSDVRVCLFFLFLLQSAFFSTGNIASVSSFSLDAVYRLIPIFEPFSQAALLIFKILAPFALVSTNLGFLTKRLKLQGGSLFTVVMGIGDYMTLRFFWAVRDEGSWLEIGESISMFVIASALCVFVAGLEALSEVFVRGVEFEDDKQEVRGRTGFPSVGLGSGGPMRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLQ7</accession>
    <name>D4DLQ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_08131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017875.1">
        <property type="nucleotide sequence ID" value="XM_003017829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLQ7"/>
    <dbReference type="GeneID" id="9583770"/>
    <dbReference type="KEGG" id="tve:TRV_08131"/>
    <dbReference type="HOGENOM" id="CLU_009397_4_2_1"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056603" evidence="7">
        <location>
            <begin position="40"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="36479" checksum="5E5000312AAB0C67" modified="2010-05-18" version="1">MGKEVRPALLSTRLTSPSTSPSLVLLLALWTAALHLVSSAPMPNLSMKIPRVGNPVLNGWYADPEARIFNHKYYIYPTVSTVYENQTYFEAFSSPDLKTWTSLGKVLDFKDVPWSTNRAAWVPSVAFKDGSYYMYFSAGDGVGLGVARSSSPEGPFKDALGKPLISESYFGAQPIDADIFIDDDGRNYLYYGGHSHGVVVELNDDMISLKGEVKEITPKAYVEAPWMLKRKGVYYFMYSTGGKSPLGPFDGEPVKILQGDTAIGTGTGHNSVFSVKDDYYIVYHRRFPDDNERDHRATCIDRMYFTDDGRIEPVKITTEGVEARVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ86</accession>
    <name>D4CZ86_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA interference and gene silencing protein (Qde2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025709.1">
        <property type="nucleotide sequence ID" value="XM_003025663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ86"/>
    <dbReference type="GeneID" id="9581952"/>
    <dbReference type="KEGG" id="tve:TRV_00123"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="642"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="993" mass="108953" checksum="11E176E884265824" modified="2010-05-18" version="1">MSERGGYRGRGRGGGDRGDRGGSRGRGGGGRGGRGGRGGGDFDGGRGRATFTGGRGGRGGGGRGRGGSPSIYGEGHPVPPPDAEVQKIEDTYIKQRKGLSLDTLKLSQAFPLRPAYGTRGNPVVLWANYFPLVPQTGITLYRYTVNVGVEGKQPPGYRKLKRIFEILLEDHLSAFQGHIATDFKATLISTTSLDLTSESLEVAYRDEFDAVAEPNAPRYPLRIVEIAPLVLDELLKFLKSPGADAFGQSKEEYLQALNIVTGHFPKISLDTFNVGPNKHFKTKTKDIFDLGGGLNAYRGYFVSTRAATSRLLVNVQVKHTTCFYDGPLVNLMTSTHNLFGLKQMNNLLKGVKISVTHLPPKTNKKGESVNRTKTILGLATAKDGASCEFPPKVEHSGAGPADVQFYISGSEHFETGYHSVYDYFKVRYKIELDMRSPVVNIGTMANPSYLPAEVCIIEPGQSIRSKLSPAQTQKMISFAVRRPKENAEAIVNHGAQIIGATLQPQATDTMGISFTPKLITVPGRVLSNPSVRYKGQGVAAIRSGSWNLNNLTFRVPGAPLKDWAYVMIGDGHIPSDPDRAVTDFINTARAQGLTLSPPLKAGGNTDGLAWVVNYRDPGNVEKNVDEMFRRIKSNANLKNARLLLVILPNDNPTVYKRIKLNGEVFHGIQTVCVIMSKFTKSSNVQYHANVAMKFNLKLGGTNHVLDDSKMGIIAGGKTMVVGIDVTHPAPGSSETAPSVAGMVASIDKTLGQWPAILRLQREAKQEMVDDLTDMLKSRLRLWHKKNGVYPENILVYRDGVSEGQYGKVLHEEHPRLLRACKELYTGGVTAKLPRMTIIVVGKRHNTRFYPTKAEDSEKDNARCGTVVDRGVTETRNWDFFLQAHTALQGTARPAHYYVVLDEIFSRRQNPAYPTVADELEDLTHNMCYLFARATKAVSICPPAYYADLVCERARAYLNYFYDENLSQKSGSASVASAKHLQPHPNVIDTMFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZH3</accession>
    <name>D4CZH3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025575.1">
        <property type="nucleotide sequence ID" value="XM_003025529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZH3"/>
    <dbReference type="GeneID" id="9581813"/>
    <dbReference type="KEGG" id="tve:TRV_00215"/>
    <dbReference type="HOGENOM" id="CLU_095045_1_0_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="16849" checksum="AE338C5EB3E05763" modified="2010-05-18" version="1">MSAQIPNTLTGGCLCKEIQYTIDVPKDISWPPDCRKATGSIIAHLITFDPSAVKWNGTPTEFESSAQGRRGFCSKCGTSLYFRDIGLPAEVEICTGSLDEEILENPQLANDLCDPSCGRFWCKREIKSTIYENSAGKRWLEGSKSRPMYDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZQ9</accession>
    <name>D4CZQ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">A-pheromone receptor PreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025539.1">
        <property type="nucleotide sequence ID" value="XM_003025493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZQ9"/>
    <dbReference type="GeneID" id="9581776"/>
    <dbReference type="KEGG" id="tve:TRV_00301"/>
    <dbReference type="HOGENOM" id="CLU_027592_3_2_1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="406" mass="46307" checksum="3A6E3340D86DB16C" modified="2010-05-18" version="1">MWILTQNLFNFINPLIWPDDDFNSRWMGYGYCDIQSKLITGAGVGIAGPLVCIFRSLAKVLDTERTTLVPTKGDRRWNITFDVIYCVIIPVVIMVLHFIIQDSRYYIYSIVGCMPAYHSSWVSFVVGYIWPPIILIIACFYCALVLYRLFKYKREFSQLVSSDSSTSKSKFVRLLTISLVLLLGSLPAQFFVFYTNITSYKPWAPYSWSEVHGPHWGEIIKFPMHGQVYYDRWIQAAAGFLLFFFFGIGHDATMMYRSILLRLGFGDCFPALRHPHIMINQRQGSSSTRFGSFSSTVKMALGRKKPLTSTIDSDVTLNEKTRNMSLDGCLFNELEPSFSMDNQNSAQKPYQMPTVPTPINHPSRLNMSRKQRRQSGDSIFLEFLTETPSSSAVKGGREAKSGPDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZV6</accession>
    <name>D4CZV6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025480.1">
        <property type="nucleotide sequence ID" value="XM_003025434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZV6"/>
    <dbReference type="GeneID" id="9581716"/>
    <dbReference type="KEGG" id="tve:TRV_00349"/>
    <dbReference type="HOGENOM" id="CLU_748393_0_0_1"/>
    <dbReference type="OrthoDB" id="4174001at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="359" mass="38066" checksum="1A82F6D02F09DF75" modified="2010-05-18" version="1">MPLFASLFSRRRSRQTREKEAASSESASNDAVEASAGQKNGTNHKAPRVELDFPHINPSSATSQPAAENEPRTPARGDDDKPVNPASVELPVSPQNEQPGSPGIVVSKKQSLMSVRSDGQQPQPQFFKEGKRRARRMSVFSSLRSRPSTAMSTATEPAPELQMSPVTSHVNRPYFPPDPKFQLDLKPDAFGKAFTGSSLPFVEEMFGNNGGENNNSVGLSGTSTTTTAATTTTSSLDPGNNVSRGWLLPDLKSVMDGDTLNTNHTNATLNQSSCSADNDGTANQTTPHANSEKIEETSSESLPSPSSLPPLPASPEPGSPKSPSRSSLKRLLSKRISPETQQGSTLADTNTAAPNGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0W1</accession>
    <name>D4D0W1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MHYT domain signaling protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025128.1">
        <property type="nucleotide sequence ID" value="XM_003025082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0W1"/>
    <dbReference type="GeneID" id="9580621"/>
    <dbReference type="KEGG" id="tve:TRV_00707"/>
    <dbReference type="HOGENOM" id="CLU_008375_2_0_1"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="793" mass="87851" checksum="4649EDD42FDC72C2" modified="2010-05-18" version="1">MVRHGPDLESLVVVYQSFHPEFIFLSYIVSFVGCATCLELLHRRTARIGLYNWYLLITAAVCMGGIGIWCMHFIGNCAIRLHRGDLQYQISYSSSFTVTSFFLPIVVLLFAFYFIGASERAGYWYIIATGTLTGLAVCGMHYVGQLGIANYSCTYHVGNVVGAAVIAICASITALGVFFRLRASWTDNWWKRLFCALILASAVSGMHWTAAVGTIYRVSNADGTSVQLFSSSQAVIICCTLSLSSCFFLICLAVVAGRQRKRMAKRVQQLSLACAYFDSSGSVMVAPDGSIPTHKITNHYVERSFADDEFNRVHPAFLWAFRASRNWAHLKQFIRGMNYNIKSDESMKQYFPGSTTTPDTGDTNINFELIFKQLFCIAAQGLSDQLHLPLEKLGVLYDDVVLTGTQSTKPSKYRAGDPEAAPTPTTIVGKGQCIFIVRQLSKQETIDLSMSGYRFAAPNHISGALARLMQVEPRDMLDNLTRMRDYSAPEKMLDPGVYLVGFSLYPSVWTGFDVLVYDDAPNLLPNVRLPIESVTQQHLDILSRMDGWPLSLCLKWLKANGGFEDPEAQTFCQAVYGAASNLSASVDSPTFGQAKFSSRQINIPCRSPGHAEATGQCTAFSFHIINGLLTRTTPPHLRLTPLRLFNVQQQVYPGIPDHAVFQDNLRDEFGHCLYDDDLKGRRSPIPPSTAQSMSLRANSLIHPGDDQKKSNRHSGNRQSDTWRPTNGGIMIRNQITVDVSQKEEPKPSSAGAFEMQSVGATVEAGYVKDDNETFVDELCAICRKAAAEQDRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D107</accession>
    <name>D4D107_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025095.1">
        <property type="nucleotide sequence ID" value="XM_003025049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D107"/>
    <dbReference type="GeneID" id="9580587"/>
    <dbReference type="KEGG" id="tve:TRV_00753"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="706" mass="77970" checksum="700C59818DD9EA1B" modified="2010-05-18" version="1">MEGALDPETLYTKQNCIGISPLSQNPESVCRDGYLTVDKRTGQSVAIKIIDVENADDEVEDIIQEISILSELNSPHVTKYHGSFLKGSDLWIIMEFCSGGSCSDLMRAGRISEEYIMIILRELLLGLDYLHNDNKLHRDVKAANVLLTASGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITAIELAMGEPPLSDIHPMKVLFLIPKNAPPTLQGAFSKSFKDFVDLCLRRDPRERPSAKELLRHPFVKRAKKTTYLTELIERYERWFAKNGNRLPDDDEDDAYHQQEQNQPAMAGGDDDLWDFGTVRPAGGNRAAGLRAMNEAAANARAQVPNMHSRAQSSSGCLPTSQENIPRKMSKETVKNPPSPQRRNFPSETPPATPNSQVSRVPLPTPQVPQTQTPRQSSYHDQVKTPLGFGKPQPPLPAQEEESSSTHDYDRALQRSLAQDLNFLKLAESPNNTPTQPPPKPPAPEQIHRKPAPMQLPEIPPFKGASSSPTPQASKPPGQYPAAPLSAHPSSTPSSYQQQQHPLPSTRPQPPVPSTPERSPTHQSSRDSLDSVSSQSTVHFSSQDQPNPNEPITALNGVILPALEAALHRRTYALNSMCRVQPGTPVSQRPSTEQVQRQVYAHEKLKRLVIKAAGILKEIERWDNEAPLGMGGDINAFLEGFLEEVLVRVEPEEDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1B5</accession>
    <name>D4D1B5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024944.1">
        <property type="nucleotide sequence ID" value="XM_003024898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1B5"/>
    <dbReference type="GeneID" id="9580435"/>
    <dbReference type="KEGG" id="tve:TRV_00863"/>
    <dbReference type="HOGENOM" id="CLU_024395_1_0_1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="413" mass="45963" checksum="4794389A3B6F6F47" modified="2010-05-18" version="1">MFPPEIIAMVLQHFNVPALLKLLRVSKRWSQLTVSLGQAFSRVDFTLARQHTVPFQAVRAYCVRHAKFIESAVVGCVTPQNASKTLRLLSRCPRLAELSLNVQLAAPEDIKILHDFTGLKQLVVWHRELTFAEFNSLLAACHTIEYAKLLLGEAKKRQDWKSCSPAPRMRSLCLTFYEMTVANPFFFDSSLKDTMPVLENLEVSGVDVEMELHGVDTDLSDHPSLCALSLSKFTLDAALKALPKGLEELTLNSVLVDPAIGTIPVYSFLTGLSKLREISFYSLSYDVGFMLDGYFSALESSLTPDLTILNIAYCNITAEELVPFMKKGHLRLVTELGIPGIMGMNDSITEVITDTMPNLKMLNLSLTEVTGYSVKLLADAPNMKLERILLLNPATPISRDAIEYGRSKGITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D4</accession>
    <name>D4D1D4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024963.1">
        <property type="nucleotide sequence ID" value="XM_003024917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D4"/>
    <dbReference type="GeneID" id="9580455"/>
    <dbReference type="KEGG" id="tve:TRV_00884"/>
    <dbReference type="HOGENOM" id="CLU_1636641_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="162" mass="18238" checksum="942BBE0689B63B3A" modified="2010-05-18" version="1">MWCAPFATTWEAGSRSGSRVLETAGAFDSAREASLERTRKCRSTQRARRKGSRATEDAAKRARGREEEKKERRARAERKKKAVSLYRREMETGDGDEDGDGMKAEVKAEVKAEVKTRGQGEKARREQSRWVEEVQRHHGPALSAFSSSLFFPTARSTTAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1E5</accession>
    <name>D4D1E5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024974.1">
        <property type="nucleotide sequence ID" value="XM_003024928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1E5"/>
    <dbReference type="GeneID" id="9580466"/>
    <dbReference type="KEGG" id="tve:TRV_00895"/>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="143"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="435" mass="48644" checksum="3E18FF3E0CF5C977" modified="2010-05-18" version="1">MAGKSRFTRLDAFAKTVEDARIRTRSGGVVTIAALLIVIYLVWGEWKDYRRVVVQPELIVDKGRGERMEIHLNMTFPNLPCELLTLDVMDVSGELQTDVDHGVNKVRLSSAAEGGRVIDVTALALHKKEDSPAHLDPNYCGDCYGVPAPSTAKKPGCCNTCDEVRDAYAEKNWAFGRGENVAQCIDEGYSQRIDEQRHEGCRIEGILRVNKVAGNFHIAPGRSLTAGNFHAHDLDNYYHTPVPHTMTHIIHKLRFGPQLPEELYSRWKWTHQDTINPLDKSEHKTNEVRYNFLYFVKVVSTSYLPLGWDPTLSSEAHSQAHRDIPLGNHGVFFGSQGSIETHQYSVTSHQRSLDAEDASADGHKERQHSRGGIPSVMFNYEISPMKVINRETRPKSLSAFFTGVCAVIGGTLTVAAAVDRLLYEGSLRVKKLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L1</accession>
    <name>D4D1L1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024887.1">
        <property type="nucleotide sequence ID" value="XM_003024841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L1"/>
    <dbReference type="GeneID" id="9580378"/>
    <dbReference type="KEGG" id="tve:TRV_00962"/>
    <dbReference type="HOGENOM" id="CLU_393269_0_0_1"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="701" mass="77055" checksum="6678E39D944B37BC" modified="2010-05-18" version="1">MDSTHSLTDTPTPKPLEISKIFPKANENAAALVKKNVCSPCRIPRRRSSHVVRPPLLPLSTTQNVERSNKPITARQHQRLHKATALHPKAMENLTVEKRVWDGRASSADVRQRQPTPKGPNILSRAINALAFRSRECSGNQADNTARAHGFRLPSLQKASIIRGKGSEVNLRGHTGIQTEKKSCDGLYEKAQIHRHQTLSFVGDNPLAPKPRDSAAQIPRIPRHIPITSAAVNLVPNSLKSSPGQDNSTWVSAVVTASINDFTSGVNINGPYDADIPLDVMILVDNSNAFQLASVLDILIDRIAICCISPDPTQNLNLLMPLSSYSLDTVEILFRSLPAFQLPHGESSRSRLAGAIKEASNYLIRHSSRGASCHMFLVSAGSTVLIPGESNGDKLRYHTKSPDNAMMINSCQSLEGWHIGTNFGSEEQSSVDLTFRSKLQFAIQHLRIGIDSGYLHDLVLQLEAGPDSQIEAILGDTNRRVLRLGESWTVLVKVKPIPELQGPINSGPATANRENEPHTPNESTVNRMIDQLQGMLKPASNTLNNEHNIIASLEYKHSALSGNTILLTRNKFTIPRSRKAVTWDDSVKPPAPRSNSAISHRQIIKPPIDSEVISVKKRQQIVSNVAGNGYQPKKSGKDIANGASVIRENCLSYRDMSPFGSMNPYKDICKHADPITSQQSLGRIPEYGHLHRLEDPFARIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D229</accession>
    <name>D4D229_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024724.1">
        <property type="nucleotide sequence ID" value="XM_003024678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D229"/>
    <dbReference type="GeneID" id="9580214"/>
    <dbReference type="KEGG" id="tve:TRV_01131"/>
    <dbReference type="HOGENOM" id="CLU_011743_1_1_1"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="653" mass="70987" checksum="5685BC831F6D6C81" modified="2010-05-18" version="1">MASTASTPPPKRKFVPELIESTTKSSSSSSSRTQAKGRDASTTTASKGASRFRPQLIETTTETSRKAVKQGGDGGDKGKQRGVGGSAGRAGLGVADQQQKKSRDAAATKTSQAPRKFTPQLIETGKRSFRQNPAGSPARQNFGSSSVCSANTLRFRATDSESKYSYASLSRRHGSRRQSFQVPNLPAIPSTSSENSGESPTSSLSTSPTNFSNEGSHQNVHVHYPDSYTGSYPDNHMYNLHSRLVSEKLKDQALAAFPNEQVYQPVSHFAIDREDSNSEDDDDSMETAFRQLSIDLSRFRRESTADLAWELEEMRRHKEESEMRSRERLFAANHTSKFSAAALAARYKEEWEGLETGGYDIIGGWQKGANLAPMREAASPPMLGDDIVFTRCQSPKSTLVGADQLPTPATSQNKKPAGNCNAGGLWSADTNMSDCGQVGLWNGTCKRKSGGQTSCDRSSQNSSPQKSGLVTPAPERMDPVLPPTPTPTPLGSLIQPSKEISPDLVTLTTIPDSSSPSPAILIQTCDPDLEREIEAEFNDSFVTQIYNYLSLGYPCLARDFDAELSKITNIPIETLQSDDQHANAKGYIDLPDCRTGACNTTTTTTTTTTTPGCVRWNALKLYIHEWARQQPRSGADRGVDSWGVPERRGSWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2J4</accession>
    <name>D4D2J4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024587.1">
        <property type="nucleotide sequence ID" value="XM_003024541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2J4"/>
    <dbReference type="GeneID" id="9579911"/>
    <dbReference type="KEGG" id="tve:TRV_01299"/>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="125"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="719" mass="83045" checksum="93800253BA44E49C" modified="2010-05-18" version="1" fragment="single">IIILTATAQKSLRELKSKISTQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDPADIQEGAFPNDDKTQKYGNLLFLLQSEPRHIAHLCRLVSMAEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPEYSSLLRQNTPVSRMMTTYTRRGPGQAYLKHILAGQINSLIELHDIDLEINPLKVYESMVQQIEASTGSLPPYLERAVTAEVAAENEQVQAIIAPRLKMLTDLANSFLKTIIDGLEETPYGIRWICKQIRSLSKRKYPDAQDHVICTLIGGFFFLRFINPAIVTPRSYMLIDGTPAEKPRRTLTLIAKMLQNLANKPSYAKEPYMAKLQPFIQQNKERVNRFLLDLCEVQDFYESLEMDNYVALSKRDLELQITLNEIYATHALIEKHASTLAADQNSHLNVLLQELGPAPAQLPRKENRAIHLPLFSKWEAPIDDLTSALDITQEEIFFMEAKSTFVQIMRSLPHNSSVTRRPLRLDRIAEAAATLKNDAVMVRKGIRTMELLSQLQELGVIDRSDDFSLLRDEVEQELVHLGSLREKVLEEQRKLEEVYRTIRDHNAYLVNQLETYKSYLHNVRSQSEGKQRKTQKHQELGPYKFTHQQLEKEGVIRRSNVPENRRANIYFMFKSPLPGTFVISLHYKGRARGLLELDLKLDDLLEMQKDNQEDLDLEYVQFNVSRVLALLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V0</accession>
    <name>D4D2V0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024443.1">
        <property type="nucleotide sequence ID" value="XM_003024397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V0"/>
    <dbReference type="GeneID" id="9579665"/>
    <dbReference type="KEGG" id="tve:TRV_01406"/>
    <dbReference type="HOGENOM" id="CLU_1994273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="125" mass="14063" checksum="BD7FD8E00C070089" modified="2010-05-18" version="1">MKRLGFETREIAEKVVQQFHNVVGKDGVKLLLRFADTKAQKQLKHQSNERRAYRAGEYNYSVELVNSATPSPSLHRLQQAASHFSPTSQNSYPSPIGSVGQVWTPATSISPPYEFSTPLLQLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Z3</accession>
    <name>D4D2Z3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_01449</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024383.1">
        <property type="nucleotide sequence ID" value="XM_003024337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Z3"/>
    <dbReference type="GeneID" id="9579522"/>
    <dbReference type="KEGG" id="tve:TRV_01449"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_0_1"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="583"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110221" checksum="6FBC35D10460FBCF" modified="2010-05-18" version="1">MSTPSSSRRRGRPSRSSANSTPSRGTAQPQVVISSPAPSRQTQDNSDQTTTPRNRRVADNGIPSSSPIFFQSSPAGAGPAANAAPDRSSPMPSSPLGDRDTTPRPTRPLVEGRPGNSQARRNDIPTSSSGLFIRSSNPNGITTRRGDIHSDTFSTTGSGRRTLFVDESGLPVRNREPLSDATFSNLNPDTSEAEILGGNSTRVIWGTNIAVSDTMSSFRNFLYNFARKHRMIYDGATESEIRALGSSADEKEYVRMLNEMRQLGITGLNLDLRNLKAFPPTTKLWHQVQSYPQEIIPMMDQCIKDVMVGLAGEEIERARQRNQRRPAAAARDASSIPAFPSSDADGNGNAPAQQDLSSILADIESRTYKVFPFGLDKSINMRDLDPGDLDRLISVKGLVIRATPVIPDMKEAFFRCDVCFHCVRVNIDRGKIAEPTRCPRQLCDAQNSMQLIHNRCIFADKQIIRLQETPDSIPDGQTPHSVSLCAYDELVDMCRAGDRIEVTGIFRSNPVRVNPRQRSTKALFKTYVDVLHVQKMDKKKLGIDASTVEQELSENLSREVDQVRKISQEEEEKIKQTAARPDVYELLARSLAPSIYEMEDVKKGILLQLFGGTNKTFEKGGNPRYRGDINVLLCGDPSTSKSQLLKYVHKIAPRGIYTSGKGSSAVGLTAYVTRDPESKQLVLESGALVLSDGGVCCIDEFDKMNDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILASANPIGSKYNPNLSVPQNIDLPPTLLSRFDLVYLVLDRVDEQNDRRLAKHMVGMYLEDAPETGSSEEILPIEFLTSYITYAKTRISPKLTPAAGAALTDAYVAMRKLGDDIRAAERRITATTRQLESMIRLSEAHARMRLSEEVTADDVEEAVRLIRSALKQAATDARTGLIDMSLLTEGTTARERRLRDDMKKAILAIVDELGGRGTGARWADVLRKLNEGTVPVEGAEFMEAVKSLETEGLVNVVGEGARRTIRRVLGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D313</accession>
    <name>D4D313_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024403.1">
        <property type="nucleotide sequence ID" value="XM_003024357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D313"/>
    <dbReference type="GeneID" id="9579625"/>
    <dbReference type="KEGG" id="tve:TRV_01470"/>
    <dbReference type="HOGENOM" id="CLU_019524_3_0_1"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49077" checksum="74F888D84C03C6BE" modified="2010-05-18" version="1">MNGNKQTNNRLANAERTRYKFKQENVFRSSQQSQQSQSKSLATRKKPAVGQLPNFETLVFVEEIPRVPVNGITALRNSFIETMKPTTDLRYNLAWSFGGFLVDIPRRLGVNEALDSAVQVLVDSHQDFCAGLGVTSRVLVGYSRALRMLRSYLNDPVKARTSETLCSVMVLLMCQRFIGITEGDFTGHCEGAAQLLRARRYYDPNDEFESKLILSLRGPVVFEGLLNQKIQFTPEEWKTLVENHLDGVTPEGRMMRGVAKVPGLLNRARKARKDGVTDENLLIDALAAYHMAKGAADELREKYKKAGLPPKGEFSFKDPIVMAHSFYQRSFGLSLPVVIILSCVVTGIDPGNAVVVDPSIYIDEILEIAGSAMIYRPLAASFVPMCLMMAWISTGDLARRKTIEAALKAYENDYAEGQAVVMTPKVEQISRMLRLVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D378</accession>
    <name>D4D378_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024337.1">
        <property type="nucleotide sequence ID" value="XM_003024291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D378"/>
    <dbReference type="GeneID" id="9579476"/>
    <dbReference type="KEGG" id="tve:TRV_01537"/>
    <dbReference type="HOGENOM" id="CLU_031989_0_1_1"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="555" mass="60682" checksum="E07E5A784C19C122" modified="2010-05-18" version="1">MKRFIGTITTFGGLDASQPNAHDAPEVAVLKAVENDFLPLPTIVEAAESSPAAAKVAANQIHKYLSKPTTTQPKRQYNAIMLIRILADNPGPSFTCNLDARFTSSVKLLLRDGRDMNAAQILRETLETLSTTKASDGNLSGLIQMWTKEKEKFERTYGYPPFGTPPVQSPPHGAGPHAGQRQDYFSRQHKLRGLPPPGELAARVNEANESAKLLQQMLMSTPVSEFYQNEMIKEFATRCQSASRSVQGYINSSNPAPDEDTMLTLIETNDKISVALSRYNRAALDARKAGFKSPAERAEQAQYLIDRIPDHNQSNNAGNQDYRNGQPYPQATGALPAGDAAPERAQSKRQRYIPRLSMPRIPKKLSKQAPEQAPGRNEETKPALYTPPVHTANVERTPASPPVSPPGTYSNNLPSIPNREAHESHASGISQLNNGHSEIRNNDRAAPSTSAPPISWEYNPNEFQVENPFADKFATDANSGLDSNRVSRITEPDGTGAATATGFPDELDQSTKRGRYYSQSDFSLFDNTKPRPSEALAIAPESSSEKKPTSPSAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3P9</accession>
    <name>D4D3P9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad2-like endonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024151.1">
        <property type="nucleotide sequence ID" value="XM_003024105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3P9"/>
    <dbReference type="GeneID" id="9577148"/>
    <dbReference type="KEGG" id="tve:TRV_01709"/>
    <dbReference type="HOGENOM" id="CLU_007575_0_1_1"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="768" mass="84535" checksum="DC222392D755F4A2" modified="2010-05-18" version="1">MGIPGLKDELGPGERISLARYSVGHLQRTRKPLRLAVDISIWLFQVQAAQGGANPALRTLFFRLTRLISLPIQPIFVFDGPHRPDYKRGRLVSKNAAAAQIELSRKLIELFSYPCHMAPGEAEAECAKLQQAGVVDAVMSNDVDALMFGSKVTLLNYSKGSAKQSGAATHVDLYNTEAEDGDSKVTLDTRGMILVALLSGGDYSPAGVALCGPKLAVEIARAGFGEDLLEITQDLLSGRSTKKAEEALCEWRERLQYELQSNESGYFKTKHKAVKIPADFPNLAALRSCVHPVTSSLKEMNALRRSDIWGRRIDVDRLRAFVGRYLGWKNAIGAKNLIRKLAPSLLSYNLFYSSLGTPKDKLPLKILGYKSADSFDALPVLKLEYVPLQIVNVDLDQETTTTSPQEEEVMNIDSSDNDDTPKESHAMVRKSTLAEYDPSASQKAWLFEAIVRRGIPDTVDDWFAECKKKEAAKKRPVKKSETRKKKPKVVDPGMKAGSILRYGTITKGPVVQRNATSSLAKELPPSSSHSLSYSDMAGTQTPPISSGKNTDLPASSEFLDLTFSDPLDDPVGLDHTQDKKDLALSHVHISERMLAGSTRPDIVCAPSQEQKIPKCKEQILVPPVQPNEAKLPKEKKAITKSPSPHPSYSATQEFPSLNQLSIELDNIYNMNPPSDTRTRHQKTDRHVLYRDNGPPAPEGIMDAFKPKMISSEHRPPALHVKIDNGFWTQVQGATTDCPCLLSSEKNSSLNCLSGRLICLGYVSIVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Q6</accession>
    <name>D4D3Q6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024118.1">
        <property type="nucleotide sequence ID" value="XM_003024072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Q6"/>
    <dbReference type="GeneID" id="9577114"/>
    <dbReference type="KEGG" id="tve:TRV_01717"/>
    <dbReference type="HOGENOM" id="CLU_047300_0_0_1"/>
    <dbReference type="OrthoDB" id="4171428at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="29715" checksum="76732C78A770F69E" modified="2010-05-18" version="1">MDPIKKSPQLSQEKFDNRSQPQTPSPRYTNKADQQYSHHRYISEAESYTAHWENSILYDKDINTRVSSPGFFRLRSEYRSPYLGPVGWTIPSKYYSTTRRSPRRPLNSYEASTDENHVSTVDPRTGSPRERVRNRNTVSAYSCRASRPFLIYQDPEWVVPPQGVTDVYFDSTASDDKENSAPEETEAPIDNEELSSEQNMGIQVGRPAQENAGDIDGHDEMDIDRDESRIILTQPSRREMPQYQHRRDTSSMSSPSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S9</accession>
    <name>D4D3S9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025852.1">
        <property type="nucleotide sequence ID" value="XM_003025806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S9"/>
    <dbReference type="GeneID" id="9577103"/>
    <dbReference type="KEGG" id="tve:TRV_01741"/>
    <dbReference type="HOGENOM" id="CLU_023584_1_0_1"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052886">
        <property type="entry name" value="LCS_TC/CRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23261:SF79">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23261">
        <property type="entry name" value="GROUNDHOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUN" evidence="2">
        <location>
            <begin position="448"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="666" mass="72690" checksum="AA7F0B942BB10656" modified="2010-05-18" version="1">MAPPRRTRRLTPSAAGGASNEADNPYLPSIETQQTFSYGGSATPALPRPLGSLPAANTAADVAASIEAAITRPARPARPAARPLTESAGFHQIEDEARKSPEKQRVTRGQQRRAESMTPPREPVRRMTPDIQLMGSLREASGEPEDHDQQQQQQQQQEQQQQSDPVDLLADAIDGSSISWNTERHLLANERPAFGLTGWPRPTSMRPQMSPSQASSTSIHQTTQQQYQQQQHPRQQQSLQKHHYQQLRGQPQRSRATAERIERGIAIGPPVGLTTITNNNNNNNNAATTASPSVRPETPSDQPAAIHTPQSEHTPASSRPPSALDNAAAPTSPTSTSTSGVTNFGFMHVVCILLSIMMALNGYLLRDEIASAARSIIYSPSGHYGMANCTESISQMMATVDQRLTSITKDISFLKQEVNKATTSPPPPKRPVNPLEPRRPNFFSLGFGATVDPYLSSPTLSSTTSYLDRLRRLAGGIRPGPSHVSALQPWDDIGDCWCASTTSTSTTTSKKENRIQLAVELGRPIVPEEVIIEHMPREATLDNGAAAPQLMELWGEFTDTNSVNNDEVRSALAAVWPGEAESAYAHEPSLGPSFVRLGRWHLLLSMYPCIHHVHVHLRNDNPRRPFVSDILVTKSCLIFFSVFSSSSSSSSSNYSPGFTIISSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3T0</accession>
    <name>D4D3T0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025853.1">
        <property type="nucleotide sequence ID" value="XM_003025807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3T0"/>
    <dbReference type="GeneID" id="9577104"/>
    <dbReference type="KEGG" id="tve:TRV_01742"/>
    <dbReference type="HOGENOM" id="CLU_2378581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="95" mass="11269" checksum="9E913BA0C03B1763" modified="2010-05-18" version="1" fragment="single">TRLLSLSLSLSLLLSVSQLLLLFYSSSTLIIFFFFFFYFSSSSLLLFFFSSSLLLFLPFHRPASAQDNSNNNNNQNKRREDEDEEDNKKRRRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Z8</accession>
    <name>D4D3Z8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024044.1">
        <property type="nucleotide sequence ID" value="XM_003023998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Z8"/>
    <dbReference type="GeneID" id="9582737"/>
    <dbReference type="KEGG" id="tve:TRV_01811"/>
    <dbReference type="HOGENOM" id="CLU_032406_0_0_1"/>
    <dbReference type="OrthoDB" id="3067443at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055592">
        <property type="entry name" value="DUF7168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23771">
        <property type="entry name" value="DUF7168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7168" evidence="3">
        <location>
            <begin position="112"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="452" mass="49965" checksum="89E3563045BCCACD" modified="2010-05-18" version="1">MCEDVMDETYNKRSRGRPPGKPTTKSPRQKASVKSLAEERPSLAAGGNSIDDRILDRIKKCLERANHENTTESEAKAALFLSQKLMAQHNVTNADLLSKESDEQVQFAGSSIVAITSTKEGSTSIQNEGFVIKAAHAMQMFFDCQFYSSRKFNSIEWTFYGIAENTVAAAIAFEMVYNLISQWALAYKGVSARFNYACGVASEMARKAGLETLNERIREEELRRQEELARLNPVQSESGPISDDQLSSQSRAPSPTDLGNPGTIPKTNNGGRDGDTSSDEEEAGCGFTVEPDFKEEDGDLLDPTADLDEEIGRLLKREASPFINLDGIQSEEEKQSHSSTGEDTAMPRDIAVASVPAASLWKSEMQLIRFRQTSKKVGDDYLKQQNIRLHRAAGGTQLSKMIQPIARAWKTVRRSMSDAEGLSEFGNLTLEHHGYLPVQSIFRLSFSLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D443</accession>
    <name>D4D443_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023995.1">
        <property type="nucleotide sequence ID" value="XM_003023949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D443"/>
    <dbReference type="GeneID" id="9582688"/>
    <dbReference type="KEGG" id="tve:TRV_01857"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_0_1"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="33164" checksum="3F847C4F0DB8D90C" modified="2010-05-18" version="1">MKNPPTIFTVNNPTNTKQKRETRDSCNQVEQVEVDYNDVSSLAASLEKHNIDTVICTIGMISPEAGQSQVNLIQAAEKSSVTKRFIPSEYSFVQSEEILHITPGVSLYIAATNALKETKLKYTRIFPGYFMDYWGMPNVRTRLKPLAYAVDIPNRRAILPGDGNNVVTFTYSYDMAKFIAKLLGTEEWPELAYMGGDDLTLNELVKMAEEISGMILTGDTILMFTTELTFFCFFFRASTGTKFEVSYDPLEKVKNNESTPLPQSDKVVYPPEIVSWVVSYESSCHYRRVQATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H7</accession>
    <name>D4D4H7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023872.1">
        <property type="nucleotide sequence ID" value="XM_003023826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H7"/>
    <dbReference type="GeneID" id="9582483"/>
    <dbReference type="KEGG" id="tve:TRV_01994"/>
    <dbReference type="HOGENOM" id="CLU_009400_2_0_1"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75320" checksum="9F62F79FA92784B4" modified="2010-05-18" version="1">MGTPDEELGNIMTEQLASRLQSPPAESSLQHEVHREDSTSHPKPEKQKGLESLDDTHNKKPESHEVKIHVDEPLHHQHHPDGFALAPEPEAKLTEHLPEEEDFPVLASDEIDPSSAALQPAVSPPFEHKHHDHIQDTESSQQMELPRPTGSGNKGLESNPRDQDESESVPVKHTKEYEPLFHDDDNERRLSPEQRFKSPVSHTQRFPSKDIWEDAPSSAQLHATVSTPDIPKRPKKDGSEHEALFETPEQEQERVREADKMLEKSGLEEPPAHLEGSRSEEEGPKQRFPSKDVWEEAPESQQLTTAVEAPADSEKSEKPEKPSLPSLPPRPSRQPDRSSTEEQGDISPTKTQTTSPTELKKRPSIPDRPKPQVPQRPTRKKGQESGEPLSKTISGENADDAAPPATKSKPALPPRAVGSKIAALKAGFLSDLDSRLKLGPPAPKPKETEKEEEKPAEKGPLSDARKGRARGPPRRKPAAKSTPAVAETEKPQTPEIKLADPWNVWSIGPDGEVNVPGSQQGKSPSEPNDIQSESPFAPPPTKATVSPPEDLESQAPPPSSIDKAVESAVFSQAAEAEGDHAPSEVTRSPPQPAAEEPLSSDLVSSEHLEEPEAPAEAETDTRGSGESNAKSEPYSGLRASGEALNAAGIMDKLKRPSFEEACVPTVEAEVERTSMAESRGEGEDAKPIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4M1</accession>
    <name>D4D4M1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023841.1">
        <property type="nucleotide sequence ID" value="XM_003023795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4M1"/>
    <dbReference type="GeneID" id="9582453"/>
    <dbReference type="KEGG" id="tve:TRV_02038"/>
    <dbReference type="HOGENOM" id="CLU_023225_0_0_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="57580" checksum="F3E7448926706BDB" modified="2010-05-18" version="1">MGQPSFQASNALIYLTYGAFLVVGLYIAWRLRNQTKGEFLSSNGTQKAIPLALNFIASALGSGILFTYPEIATIAGVQGLVVYGLSSALPLLAFAFVGPIIRRKFPEVFVLTEWTRQRYGVVAGIYLSILTLITLFLYMVAELSALQQIVTALSGLNGLPAVIVQVVVTTIYTSLGGFQVSFLTDNVQGAMVVGLIIIAVITVGARTDIDKSLIDSSGLLKPTLLGWQLIYILPVAILTNDFFLSNLWLRTFASKTDRDLRIGISIASFVVLCILVLVGSTGLLAAWSGVWPGDPPQAGSIAFFLLLEKLPNWVVGIVLVMTVALSTAAFDSLQSAMVSTASNDVFRNKLPLIYVRIGVVLCIVPVVVVALRSPSVLRIFLISDLVSASAIPVLVLGLSERMYWWTAFEVIVGGLGGILSVFIFGTIYYGNATEGGKLILLQNGLYANDWSAFGAFVAAPIGGLIFACIALGLRVGYAFVLSKTTGRHFDVFDHPLPRSHMAAGPMHLDQPDFIATGTDATIRNNDEEGAKFRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4W3</accession>
    <name>D4D4W3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023743.1">
        <property type="nucleotide sequence ID" value="XM_003023697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4W3"/>
    <dbReference type="GeneID" id="9582278"/>
    <dbReference type="KEGG" id="tve:TRV_02130"/>
    <dbReference type="HOGENOM" id="CLU_013026_2_1_1"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="744" mass="80679" checksum="03F12E9823EFAE1A" modified="2010-05-18" version="1">MLDSSETPPPLHFSPPSSEQDRTSTRESTPIGTPLGVVSSNPRRPELLHNHHLGNRKASAASPFSPSAAHIPVFDDEDEDDSIFPLFPSSPPDQHHHHQHQSSHHQNRSQLGQRRHHRYNSSQHSVTMDGRAMPIDLSARQTSKSPPGQQASNLTSALQKAATGAADMSSNWNGVASNNFMSNAARKESFSATMAQYSNGSKPITMVGSNRDKPRRESLAGSLVGGMSWGGVSVGSWIRDDIIMTGTSPFTLQSPSYHSSSYLPKLEANFMRDFSCCGITLPSLHDLLQHYEEAHAQRSPQPPQRSAQSNQAAQSDNRAGIGASPHPSQPSQQQPNMATAPGRAASSQPGTPRPHHRLPQQPQQPMMQTATGFGQPQSNDIPDIDSVDDMDMEMDDPLSDSGFQQQTHQQSLTQARFAQENGGSRVTPLNMGILQGQQRFRSSAPGTPVSSGRPLHNNPTVSSVNTPTLMPLPVQQQQQQQQQQQQQPQAPNPQYTSTPEPSAPGTPAELDDSIVGGFGDMNMQGTATPVGTGPGQQQFGTFGSNGMLDLCIDEPAKRLFRPNTGFGNGKQVQQQQQAPPFRLGNSHYAANSEIAQHIREQQKLAGVPDVTLAMKPDDEPKPFRCPVIGCEKAYKNQNGLKYHKSVSRVLHYHSSSSFFVDPETCAPYPGTLGMEKEKPYRCEVCGKRYKNLNGLKYHRAHSPPCNPEFSFAAAGRAFNTAGGVMHGDNINIAGAGLTGIGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D544</accession>
    <name>D4D544_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023639.1">
        <property type="nucleotide sequence ID" value="XM_003023593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D544"/>
    <dbReference type="GeneID" id="9582185"/>
    <dbReference type="KEGG" id="tve:TRV_02214"/>
    <dbReference type="HOGENOM" id="CLU_005860_0_0_1"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="889" mass="98369" checksum="DDFF8D2C014A35ED" modified="2010-05-18" version="1">MACIFGPGGSSPNEMSPRMPAATSPDLIFSEGEEGEQRPMARHSQLSTFERVLSTHPPILESFLLQTPTESILQLYHTSSYLRSFLKSYPTAWQYLSFRLLLPSSTQVRPLVGATDSQGNQRQSRPYALDQLLLHVIVPFSPSLRSLDLDNTAVSGQNLISIVLSARRDTLEHISVRGCKNVSLKYHIIPYLTMFGLQYDTETTNPLGPSSKVKRLAIKSLYTYRCRHHRRRPYLTSSLLRRDSDSEPTHELVNLCHKLGIWTDTAWCTTPAGRCFRRRGYVAMRVPQGSPEVWVVFDRLWRSKNWIGASGDSNEPPKRDGRLWEHDETGHSGEPLGTPGAQKYGEGKTVPTHLRSSHKRFVDDIKCDACLEKIHERCEQCSVLMHCVGCRKTLCYSCAYDTPYPRRKTASVGESAGETFWWAPGATISPCAMQEPYQQAIGPNTVNNQNGMANSPVYPNLKLHWCCTEPMFTGGGGITLGVAGREVDRVRAAPLPRGQGWEDPEYSSNEWSKNFPKYAYGDPKKPDYTLAEGHTEMMRWLLGPSSCQVSSCPRNLCQDCFDSPQWKVHCKSCSKPLCMEHDLRGLRLRICGYRDLLLEKLAIGDGRTPASSAASATSPARPALSTSASYAPLRLAPPEQSHGGASSSSNPLPNETNSSIPATAAMNATDNQNADPASSSTSNNHTRSSTPASVYFEAAPQSRKWLGCQSFFCPQFRAAGDHRQRCTSVLSECTSCSVHVCQDCVDENPPCTCSYCDLNYLCPNCYVTKEQDGTCRRLEEERARRDEKQKRDLEMFEVALERNLANEVAGYAGQFFSQVYHTGEPVHMSEQPTEAVGEAPPPLTQLDGATNSHPPAQPGASQHTATYDDDDNGPAGSGSEHTEILGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5J4</accession>
    <name>D4D5J4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023472.1">
        <property type="nucleotide sequence ID" value="XM_003023426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5J4"/>
    <dbReference type="GeneID" id="9583517"/>
    <dbReference type="KEGG" id="tve:TRV_02366"/>
    <dbReference type="HOGENOM" id="CLU_1975918_0_0_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13468" checksum="50196BAB1E852C76" modified="2010-05-18" version="1" fragment="single">FRPKGDFIISYHPEIKSLFIATGGSGHGYKFLPVLGDKIVDAMQGILDSDLARLWAWTDNPVTTPAGGLGVVWTEDGSRSGARGMLLVEELEKSTISNCPSTSTSTSPSNGPSNSTNDGDVKVISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5R3</accession>
    <name>D4D5R3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000127">
        <property type="protein sequence ID" value="EFE42808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023426.1">
        <property type="nucleotide sequence ID" value="XM_003023380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5R3"/>
    <dbReference type="GeneID" id="9583446"/>
    <dbReference type="KEGG" id="tve:TRV_02436"/>
    <dbReference type="HOGENOM" id="CLU_007029_0_0_1"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="910" mass="97597" checksum="726A139D4BBFE8DF" modified="2010-05-18" version="1">MPDAMDVDAREEGELSSCEETVEQRSPNPERLFAPYAQNSRSIQGAAGNKPQQNEPQSQSPSTNLHRPVHNNPEKTNSTKDNAHANPLAGKSPSQLKALAQGALLNLAPHKIRYNELVREGIDPIILKSLYDEIGIKVTTEPLGKSVGIVKELGEPKTSNTGFSPAANPIARDESVTKQNATQDTGASSSKPMERKDVIARMLAAKAAKSTPPSIPTAKTAKSDQVTASPSQPTKMAIRSLDESSPQKTQTPAQATPEEVRVKEKNKAQTELARQRMEQLKKLGLGKSTPQIPGLTSSPLTSSADIPVSTVSQESRSLPHSLPDRPPPSGMPGLTQIPGLVLTEADSHKTNDLVTAEKPQDGLKDNAETSRAPRKRPRASDFTDDPEETQTRKHQLSTRSASAEQKVIIDISDDEAMYGGSDNEGRAMPNHTNTPRTIRSTKSTARDLPPLSDFPPKSRGSHRSTPGTMSNTPPNPVNGLQQKNMEILAMRQRIAELEARRIKKQASSQNQSSGSSNASAGVTSDGTVQETENSSSELENAQKAPTPAVEGGIIGIVDSASPLPNSTSTTSSVQPPAASNLGVNRAEELRLKALRRKEIESGLPLLDAEILKTEQKLAEFREQEKRLVDQIAKGREGKRKLIEELESLGIETEGLSISELKEISDEVGNINDSSSKQDIPANTSTTDQEIQRSPADKEEGLATSIPSSTEMAHNVENLVSQDSTAHEIGSAQDTAMENASSGGPRETREESYSSSAMDESMGSSEDESGEELASMAKSTSLGSPDDDEMVIMKDASLSEEDKISQHIPQEKSTNSISSNPDNDGEPQFTPRGESVASEGYEPPEPDTLESPPFSPAPPQPIEQISMELSPGPEDPDAHALTLSKQEADSPAILAPSTVHNLLFTLAIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5S6</accession>
    <name>D4D5S6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DnaJ domain protein (Mas5)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023347.1">
        <property type="nucleotide sequence ID" value="XM_003023301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5S6"/>
    <dbReference type="GeneID" id="9583367"/>
    <dbReference type="KEGG" id="tve:TRV_02449"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44333" checksum="20364984A1DCED5C" modified="2010-05-18" version="1">MVYLSSRESHRQKLALQYHPDKVQEDERKESEIKFKAVSQAYEILYDEEKRQIYDTQGMSAFDGSGRPGGMGGGPDLDDILASMFGMNMGGAGMPGFAGPGRRRKGPNEEQQYTVSLEDLYKGRTVKFASTKNVICTLCKGKGGKEKATPKKCSTCGGQGQKETLVQIGPGLVTQSMMKCATCDGVGSFFQPKDKCKKCKGTKVTEEKKILEIYIPRGAREGEKIVLEGEGDQQPDVEPGDIVFHLEQAEHKTFKRDGADLSATIEVTLAEALCGFSRVVLKHLDGRGIEIKHPQKPGDVLRPGQVLKVADEGMPFKRGDARGDLYLIVEIKFPEDGWASNPAVLSQLRELLPVNKAPAIEADTVDEVEFDSKASLDSMGENDNQGGGSWVDEDDDDGEGGAQCATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z9</accession>
    <name>D4D5Z9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023420.1">
        <property type="nucleotide sequence ID" value="XM_003023374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z9"/>
    <dbReference type="GeneID" id="9583440"/>
    <dbReference type="KEGG" id="tve:TRV_02522"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="319" mass="34670" checksum="19065BDAE33B6419" modified="2010-05-18" version="1">MASKDKKQQPATAAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSKRARAPGVKARGFLATGQEIVRRETALGLYKGLGAVLSGIIPKMAIRFTSYGYYKQYLTNPETGKLSSSANMLAGLAAGVTEAVAVVTPMEVIKIRLQAQSHSLADPLDKPKYRSAPHALFTVIREEGVGAIYRGVSLTALRQGTNQAANFTAYSELKKLLKDWQPQYTELPSYQTMCIGLISGAMGPFSNAPIDTIKTRLQKTPGEPGQSAISRITAISKEMFKQEGARAFYKGITPRVMRVAPGQAVTFTVYEFLREKLEKSNWSIMGGKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D655</accession>
    <name>D4D655_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_02578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023244.1">
        <property type="nucleotide sequence ID" value="XM_003023198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D655"/>
    <dbReference type="GeneID" id="9583264"/>
    <dbReference type="KEGG" id="tve:TRV_02578"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="195" mass="22212" checksum="086E1E41438278B5" modified="2010-05-18" version="1">MGMSFSKMLDKLWFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIVRRKKEVLTGVGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQKMLNEDELRDALLLVFANKQDLPNAMSPAEITSQLGLQTLTRRAWYIQSTCATTGDGLYEGLEWLAGALKKAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6B5</accession>
    <name>D4D6B5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamyl-tRNA(Gln) amidotransferase subunit A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000137">
        <property type="protein sequence ID" value="EFE42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023224.1">
        <property type="nucleotide sequence ID" value="XM_003023178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6B5"/>
    <dbReference type="GeneID" id="9583243"/>
    <dbReference type="KEGG" id="tve:TRV_02640"/>
    <dbReference type="HOGENOM" id="CLU_009600_0_2_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="598" mass="64069" checksum="5C37A5B94953FEB0" modified="2010-05-18" version="1">MAANKNPYRTFPTPVEGPKVPYKAAQESNPILRGRVLEIAATLVQSSSFIQSILWRNAGFSTIRDIQDLTAYEPKFDPTVLPPLTQQSGTETPELPAPTRRRQDGKGDYYTSADYRELYKAGKLTPTAVVEALLPVIRRDTSPPGEFSAGFSQSKIDLVRAAAEASTQRWANGTPLGPMDGIPVAIKDEVDIDGYDKYLSSKVDFTANPSFTSWCVKKWEEAGAIVIGKTVMHEIGLDTTNNNPVVGTPKNPHNPGYYTGGSSGGSGYAVGAGIVPLALGADGGGSIRIPSNYCGIYGLKTTHGRVSSAPTRRLATTVGVFGPMASSIDDLAMGYRIMSAPDPSNPVSAAFPDPLLSIPSPSSSRGKVIGVYKDWVERSDPDVLAMFNKAIDYYRDEQGYQIVDITIPYIPEGGKCHALSILNEISSGLSKEQISQLSAPTRIIVSVGGTQGLAQDYFASQRMRHLLMNHLSFLFQKYPGIVIATPTTPTAGSKISGGEADLTNGISDSNATLRSMEYVYLANFTGCPAISCPMGYDDEPSVPVGLMGMGEWGSEEALMEWARDGEGMLGDKGLRAPNKEKGGKWVDAINLALNPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6C2</accession>
    <name>D4D6C2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000138">
        <property type="protein sequence ID" value="EFE42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023220.1">
        <property type="nucleotide sequence ID" value="XM_003023174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6C2"/>
    <dbReference type="GeneID" id="9583240"/>
    <dbReference type="KEGG" id="tve:TRV_02647"/>
    <dbReference type="HOGENOM" id="CLU_2851341_0_0_1"/>
    <dbReference type="OrthoDB" id="4167530at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="65" mass="7444" checksum="F2D7A59BD56DFB82" modified="2010-05-18" version="1">MQNSDTTNGGEENNPMTIDDMKAYYSQADVEDAMFTRNYVEYYPPLLLFSAIPTNKIPNHIQVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6N3</accession>
    <name>D4D6N3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023070.1">
        <property type="nucleotide sequence ID" value="XM_003023024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6N3"/>
    <dbReference type="GeneID" id="9583128"/>
    <dbReference type="KEGG" id="tve:TRV_02760"/>
    <dbReference type="HOGENOM" id="CLU_037236_1_0_1"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055362" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="32"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="46473" checksum="3F06A77CE41238EC" modified="2010-05-18" version="1" fragment="single">LRRTAGVPKMRHFGLLRLLAFALLFVGLVAAWSKEDHEIFRLRDELHATQGSNVTFYDFLGVKPNAGQSEIVKAYRKKSKQLHPDKVKRAFIANYGRSRKAKTGSKPGVRVSKGPTDREIEKAHKLATQQFARLGLIADILKGPGRERYDHFLNNGFPAWKGTGYYYNRFRPGLGSVLFGLFLAFGGAAHYAALVLSWKRQRQFVRRYVRQARRAAWGDDFSVPGVSNIGESAADSRGHSTAASSGENAGDEGAAPVPVNRRQKRMMERDSRKEGKKPVKAAKAKSSVNREDSSAPGSGTATPAGVETRNRKRVIAENGKVLLVDSSGDVYLVEENEDGVKEEFLLDVDEIPKPTFRDTMVCRLPIWIYEKTVGRVVGAVPDSTANDMPEETEEEEVVPQEEERTSSITQKKKKGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6N5</accession>
    <name>D4D6N5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylglycohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023072.1">
        <property type="nucleotide sequence ID" value="XM_003023026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6N5"/>
    <dbReference type="GeneID" id="9583092"/>
    <dbReference type="KEGG" id="tve:TRV_02762"/>
    <dbReference type="HOGENOM" id="CLU_024566_9_2_1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF28">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55966" checksum="FD925C5EBE7A13AA" modified="2010-05-18" version="1">MSLKNGTGLDFVSTHPFVKATLQDKIRGVIFGSALGDCIGLYTGWLFSPTRRVQRSLPKYLEFLSKKIAEDAYPQGRFQLVDPATKFRNDGHRSELCILPYSNPLQTMTLMANGKAWTDDTDHALLILLSYLHHNGQILSPTDLAERLKIWIDQGLRALDRPPCGIGKTVGSIVLDKEYLTNPSQKAHQYWVKGGRNVAPNGSLMRTHPLGIICLAFSLEKTFQVATDFSLITHADPRCILACCISTGLIRGILRGEILDEKGLDTLLEDAYTWVDSWVRDVRLPKDDAQKEADSDIYEPDAREFLDREEFNQHAYAKTFSDLLLDASYKIGYVYKCLGTAILSLRMGMQKSPHGSTPGTGSPPPLTNSAIFENIITELTYEAGDADTNACAAGALLGSWLGYNSLPSHWRDGMDNNDWLMQKCNSLIQVIGVGYDGATPYDGKLDADTSPDGGKGLMNKEELEKRDSDMIVKYMTRHAEGVAEEKARLKAEEKQKKGWKSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D706</accession>
    <name>D4D706_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022979.1">
        <property type="nucleotide sequence ID" value="XM_003022933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D706"/>
    <dbReference type="GeneID" id="9582999"/>
    <dbReference type="KEGG" id="tve:TRV_02885"/>
    <dbReference type="HOGENOM" id="CLU_014001_1_1_1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="158"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="393" mass="43982" checksum="20A5E086C336FF91" modified="2010-05-18" version="1">MASEGTAAPPQDLAKENVKPEGTMQTEANKNEKPEPAEKTVDISDLPLSAADGLIKTLFRGPLDSCKPTPPAELTAEQKSKYDSLLALVRGWTTIPTTSAKNAPREPLSDDECMFLTRECLLRYLRATKWNVASAETRLQATLTWRREYGVKEHTPEYISIENETGKQVILGYDIHARPCLYLNPSKQNTEHSPRQIEHLVFMIERVIDLMGPGQESLALLVNFKETSSGQNATLSQGRQTLSILQNHYPERLGRALVINMSFFILGFFKLITPFIDPLTREKLKFNEDMRQHVPPSQLLKATGGDVEFEYDHSVYWPALNALAAQKRQAYRERWIQAGKFIGEHEDYLKGGSGKCLRETPPTAAEAELEEKMVNLAVGNSDKPQPATTATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D762</accession>
    <name>D4D762_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022954.1">
        <property type="nucleotide sequence ID" value="XM_003022908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D762"/>
    <dbReference type="GeneID" id="9582973"/>
    <dbReference type="KEGG" id="tve:TRV_02942"/>
    <dbReference type="HOGENOM" id="CLU_030750_0_0_1"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="643"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="693" mass="74307" checksum="EB61903D1D82190E" modified="2010-05-18" version="1">MALPRNLGSRTQAENKGHSLPGPIDDSFRNTLGLHGEMQPPSCTANKGPAFSYAVDGDTLFHAGLSHMKPGSLPVRRWTDADLSSLQSGPALTPDLVLHHQQHQLQQHDHAFDAHASGQLLTAATTPAAAGPGPGGGEGGDQFHVDSGVLFQDPKEQLVGPPSSRPTAGNWMERQIYKYNHSQQPSATRRQRRQHKSTDQPATLTARKGDLLFSGHPALSSPPPSSSSSSPSPGTMASSYQDNNNSNNWFQQRLESYGLQQIVQSPECLEPTTTPASYSQTPLDRRESTSHLSTASGGSSQSPLNSSTPMSTPRYGPSIMSHPIHSSPVLATNDISETTPCQPYQDPSTVTSVPDHTSPPPPHQILRSQPCDGSPASSWHSEPMGVSAFQCAQPNLQSHETEHWWTTSSAHTIPNRSLQSPFPHASYSPAMTSASLPFRNQHQRFAHIPESIQSSGLMIGMDTSSPEISSSIQQDPVAMSSPQLSGAEVALPLAFTLPYFPQHHQRSHQHPQPPPIQTAHNNTPVSLSGSASAISAAPRSAPVISRRFPHGSAPQQSPKARYHIPPHQRRAHARKAASFSGQTSKCTKSISSNGSTHSGISSNSSSSSNNNNNSNNNSYNTVINRAVKSVSFVNFTPEDSHKLLTGVAPSGSSKTKARREQEARDKRRKLSEAALLAVRRAGGDVEALEAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D765</accession>
    <name>D4D765_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022957.1">
        <property type="nucleotide sequence ID" value="XM_003022911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D765"/>
    <dbReference type="GeneID" id="9582976"/>
    <dbReference type="KEGG" id="tve:TRV_02945"/>
    <dbReference type="HOGENOM" id="CLU_014331_1_0_1"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="589" mass="66896" checksum="F6C27FA82EE224CB" modified="2010-05-18" version="1">MKEPLARRSFLHQRRLIAQKASCFHSMASETGYPPVQALPSELRHYCSAYLEERLYTQAFNLLSSVISSRSTASGKVFAPPSQYLALAATLTVHPTTTTRSKSDEYLTASNSALHLLNLANKILGPIGGRFRDTFVFDRFANSRNERKYTTDGESTLSGADGTRVEPLNLDLAQGNSLWSRAEDFWHVVGWALNCSILHPKRWARWHLFLQFMCNVLEDDWKAREKEFKEMPPADSKSKRDCSILTESLIFNYISTTSNHVGSDRRILRAIFADGSQSSTNEFREIFRNELQEVSKKKAQASRRKGDINIDEEIYGDYLDNPDQEEEDEEDQDDPIQKTSGGSERVEARVKRQRRSTRKKSGKDDIPSDHGDDGPLSAQYDKLDHLGSLESLTIRQRLLYLLSCVSNSIPEHFMTLPRLYSFYVEFIRHLPLPTFQLFASPSVLTHFPPACQTTLCEMLLFSILENAAPASTENFLSQSKLERCFLPFTAKTNSVIDNARVSILLESLIRLLAISGLIFSRPRLSDAVAKGIEARSKKARIDVKRGQNKKLTEEFGWVWLIESGDRMVHFVNNLLPNEPEPDYIVIGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8U0</accession>
    <name>D4D8U0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022317.1">
        <property type="nucleotide sequence ID" value="XM_003022271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8U0"/>
    <dbReference type="GeneID" id="9580864"/>
    <dbReference type="KEGG" id="tve:TRV_03528"/>
    <dbReference type="HOGENOM" id="CLU_1428958_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="190" mass="21327" checksum="E7E8DED52F981241" modified="2010-05-18" version="1">MISIYEFWKFKWSKRKSSYEQGSSVWELVSQICISTALVIAWLAIRPVQNGWKSSIICPIVTNERQVLLWLRILAAMIDSAIVIMAEKLANMPIRQSSGPSLPFTTKWGLLLLGTTVSWAIGKSGAYLLSTPKEEPLFSPNIFSNFDRIILRFLLVSISIISASKWVCPKPPLPVLYLSLVSCLPNCLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W5</accession>
    <name>D4D8W5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nuclear envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_03553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022342.1">
        <property type="nucleotide sequence ID" value="XM_003022296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8W5"/>
    <dbReference type="GeneID" id="9580889"/>
    <dbReference type="KEGG" id="tve:TRV_03553"/>
    <dbReference type="HOGENOM" id="CLU_029386_0_0_1"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63913" checksum="0F6585A6DDEE19A7" modified="2010-05-18" version="1">MHVGARIATSHFHNLRLAILSLNSIQTVVWYLFSAWWFSEVYKWSSSADAQLNWVNPGKSYERSHLNERPIYLHCFFIMLALVQSSMHLYFDMDEVPVPVAKRSPLTTSRRTHRLAPLSVQFSNIAPNILFESAIIGSATAVIGPILYMLFFRRTAWSWTLYFAKLFWNFPRSAADPPGLLPPSNIMFQLRSATSGSLLVMLWQISNFLFSAFLGQAPLKKGNPLTHGAADPNGSLLNGLKSKKETVLAFAFWELCLISQEFPDRRKEIFRDIDRSGGSAWSQILKASEDILNGITSRIQEYQNPQPQATGATDGPKESGPKTQEMVQTLPRITQPSKNENILLASPKPNTRSEKFEAAFGPVAKSYGQSQDWTSAAKARARAAITHASNALLSPEQKRTISNSAQELKLLTSPPSASGPPNPIIQQFMKSPVGLPFRQSFANRLRGIALGSPHSKLAPIIDATESLKCLLIASLEEDQFGKVQTDVPSVVKLFTKTIMALESLVGKDGLKPHWSEVDSESLDGVQHSRSVEQVEIVINALKNGLSELLAAFSLYLNEVGVVGQDLQLAREAAKITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W7</accession>
    <name>D4D8W7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_03555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022344.1">
        <property type="nucleotide sequence ID" value="XM_003022298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8W7"/>
    <dbReference type="GeneID" id="9580891"/>
    <dbReference type="KEGG" id="tve:TRV_03555"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="14">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="13">
        <location>
            <begin position="193"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="359" mass="38974" checksum="D0C3409F000605EC" modified="2010-05-18" version="1">MHSILRRRCIGNVAKLQSRIYATPSALPPRHLLSIADLTPAEFTALVRNGLSHKQAIKSGSIPQSLRGALSGQTVAMVFHKRSTRTRVSTEAAVTRMGGHPMFLGKDDIQLGVNESLYDTSVVLSSMVSCIVARVGPHSDVANLAKHSAVPVINALCDTFHPLQTIADFITIKETFAPQSTPGQSTSSSLGLEGLKIAWVGDANNVLFDLAIGATKMGVDVAVATPKGYEMPTHIVDLVKHAGEGVRTPGSLTQTYSPEEAVKKADVIVTDTWVSMGQEEEKLQRLKAFENIQVTSELARRGGANEGWRFMHCLPRHPEEVSDEVFYGKRSLVFPEAENRLWAAISAIQSFVVQKGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X2</accession>
    <name>D4D8X2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022349.1">
        <property type="nucleotide sequence ID" value="XM_003022303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X2"/>
    <dbReference type="GeneID" id="9580896"/>
    <dbReference type="KEGG" id="tve:TRV_03560"/>
    <dbReference type="HOGENOM" id="CLU_040265_0_0_1"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="66"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="35757" checksum="C12E94AB0DDE5874" modified="2010-05-18" version="1">MSPLEETIFRTKAWQPLRRTREGLDKAIKKIEELMKQELPALVDERRFRRREPPERVERDEFGRPKWPEERIPIDLEPIPGFNLRAQVVGQGGQYVKHIQQKTHCRVQIKGRGSGFKEHGTNQESDEPMYLHVAGPDPNEVQNAKALCEDLLSNVKEQYEKFKENPPPQRGYHGGGGYGHRDRHQYGMGYSSGGGHHGGGGYNNHSSPQTPSGMTPQSGPGATPAPPAGGAQPDYSSQDAQYYGGQDPYAAYGGYQNYVAYYQYYQQAAQQQQQQQQQAGSTAPPPPPESAAPPPPPPPPSSETPPPPPPPPSGGYNSVPPPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X7</accession>
    <name>D4D8X7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022354.1">
        <property type="nucleotide sequence ID" value="XM_003022308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X7"/>
    <dbReference type="GeneID" id="9580901"/>
    <dbReference type="KEGG" id="tve:TRV_03565"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_2_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768096" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="506" mass="55968" checksum="9AD3CD366289F7CB" modified="2010-05-18" version="1">MHLAILLAIISLARAAPSTKGYTVAISLPGKSAFETRRLPDAPEIPKNWAGRLDIPGTPKGNSLFFWLFSAEDKAYDDNLIIWLNGGPGCSSLVGAFLENGPLRFMGNSTMPERNPYSWAKLGHVLYIDQPVGTGFASEKVPVASNKEVISNLYSWLVSFDAIFDHILRTKKVHIVGESYAGIYIPCIASEIVKRKSELPVNLVSIAIGDGTIGLNTGMSSLGMVGFLEEYASKLRIPRDIMNAISFGDHACGFDIIRQRAKVYPPRAPFHLPGRSGSANNTEISNMLRKGVADESLGSCNIHPDTPEKIKSSIVNSTCYGHCAVFETTADYMSSQQCFSICNINYGCNFTNPTSTLEAYFSRPDVQIALNLMHPTEPLRPFQSCNPKILETLMAPANRPVPPSFEILPDLLTTHKLPVHIYQGRLDMLINHVGIEVTIQNMTWNGAQGFQDSLHFEFGRRKDKAVGLWNEERGLSYHLFFEGGHFLPADLPKEVFSYVKEVVLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9J6</accession>
    <name>D4D9J6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022102.1">
        <property type="nucleotide sequence ID" value="XM_003022056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9J6"/>
    <dbReference type="GeneID" id="9578986"/>
    <dbReference type="KEGG" id="tve:TRV_03789"/>
    <dbReference type="HOGENOM" id="CLU_1300481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="212" mass="24201" checksum="C43B789127EE11F9" modified="2010-05-18" version="1">MLLFNYFGEVSTSSLIARFPMIPQDGIDFDAFQRAVCLTSLNKTKHCARLVIPVSVGAMSLNIVRMRFSTDIQKHWIPRDYYTPHRKETRSDTFYFKWDIVELVPNPCCTPTPVDEIEAAAPEILENSSALRSRETKREDVSVLINLLLRVRLGKEKWLNFPLGEIVKSDPEEGELTLRLVNGLTEGEKLPLDQYGKVEDVLINLLLVGYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9N8</accession>
    <name>D4D9N8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022090.1">
        <property type="nucleotide sequence ID" value="XM_003022044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9N8"/>
    <dbReference type="GeneID" id="9578974"/>
    <dbReference type="KEGG" id="tve:TRV_03831"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="13"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="39339" checksum="C74FF8701C527414" modified="2010-05-18" version="1">MKDITFKGWVSTSATSPLTYTTYEPKAFASTDVDIAISHCGICGSDIHTLRSGWGPTNYPCVVGHEIIGHIIRVGPEVAKLNSPSRDLRVGDRVGVGAQSGSCLRVDCEECSSGLDNYCPRMTGTYNGKHLDGSKSYGGYADYWRGPAWFVFKIPNDIPSAVAAPLLCGGATVFSPLFRGGAGPGRHVGIIGIGGLGHMGLLFAKAMKCDKVVAISRTSSKKSDALTGLGADVFIATDEEKNWARTYSRTLDLIICTVSSGNMPIEKYLRLLKRGGEFIQVGAPEDPFPGFRVGVMMGKGLKISASAIGSTEEIRAMLKLASEQNIHPWVQERPMGNVNQTLVDMHEGKARYRYVLVNGTGIETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA53</accession>
    <name>D4DA53_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha,alpha-trehalose-phosphate synthase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021908.1">
        <property type="nucleotide sequence ID" value="XM_003021862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA53"/>
    <dbReference type="GeneID" id="9578791"/>
    <dbReference type="KEGG" id="tve:TRV_03997"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="473" mass="53952" checksum="B3DC2189F1A2B953" modified="2010-05-18" version="1">MPAIESGAESRLLLVSNRLPITISRSSQGKYESSMSSGGLVSGLSGLSKTTKFQWYGWPGLEVPFDEVDIFKKKLKEDYNAVPVFIDNDLADRHYNGFSNSILWPLFHYHPGDITFDESAWEAYQEANRLFAQAIARDVKDGDLVWVHDYHLMLLPSMLREEIGDSKKDVKIGFFLHTPFPSSEIYRILPVRNELLLGVLHCDLIGFHTYDYARHFLNPEKFTEGLKREKVQKRIAALQQKFQGVKLMVGVDRLDYIKGVPQKLHAFEVFLTDHPEWIGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGRFGTVEFMPIHFLHKSVNFDELIALYAVSDVCIVSSTRDGMNLVSYEYIATQRDRNGVLILSEFAGAAQSLNGSLIINPWNTEELAAAYKEAVTMSPEKRKLNYTKLERYINKYTSAFWGHSFVSELTRLPNCAEKKVHFSQATIEDNKAIHMVPHTELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAA0</accession>
    <name>D4DAA0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PfkB family carbohydrate kinase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021869.1">
        <property type="nucleotide sequence ID" value="XM_003021823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAA0"/>
    <dbReference type="GeneID" id="9578751"/>
    <dbReference type="KEGG" id="tve:TRV_04046"/>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="175"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="375" mass="42034" checksum="8E52380A898E86A4" modified="2010-05-18" version="1">MAARDPGTLPDGFRQIDFCTLAMFIIVGGAGSFAAIGARIAAGKDHSRSVGWIVDMGYDFPEHVRSLIASWETHCVFREDMNRQTTKGWNGYEANEKRVFKYLTPKIQIVPETLTEELVLSNTFHMSCSADRCYNIVQGILKRRHELSEKYKVTLRRPIFVWEPFPDSCRPEELPRFYEVIRHVDVVSPNDHEMGSYFSNESWGFDNPRDQEICRSIVRSGIGIDGKGVLVVRAGRDGCYAFSQDDQLALPAFLDSKAVDPTGAGNSFLGALCQVLAGSNRTPIDAAREIMDQSGDWKEICTAWDDRGNILAGLICATVAASYIIEQVGVPVLSFSPQGEEFWNGTSYVERVRQYTKHLVDRKGTPKRQKLGMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAP3</accession>
    <name>D4DAP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021680.1">
        <property type="nucleotide sequence ID" value="XM_003021634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAP3"/>
    <dbReference type="GeneID" id="9576763"/>
    <dbReference type="KEGG" id="tve:TRV_04191"/>
    <dbReference type="HOGENOM" id="CLU_123438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12338" checksum="0578617D9E823C41" modified="2010-05-18" version="1">MADLLFGGTDEENEELKKLYAEVLEDTDSFEAWEKLVRAAEGQEGGINRNSSPQAITATRTVYDRFLAKFPLLFGYWKKYADLEFSIAGTEAAEMVSISHFMLSENRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB84</accession>
    <name>D4DB84_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021536.1">
        <property type="nucleotide sequence ID" value="XM_003021490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB84"/>
    <dbReference type="GeneID" id="9578497"/>
    <dbReference type="KEGG" id="tve:TRV_04383"/>
    <dbReference type="HOGENOM" id="CLU_045161_0_1_1"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="215" mass="24116" checksum="01E03E3F1C636F04" modified="2010-05-18" version="1">MTFMLLIISQYRQPPTPGHMCLNLRTQTSCQLTTSASFAPYKQPMPILTDPFRKSYLKLLSSHASEHYPNSSYGVYPSQDDSSIAILLVANKYSPNNFWNGRYRAIYNVPVSSGGTITGTIHVDVHYYEDGNVSLNNKKPVSISITSASPADTAFKRIVTTEREHQEELNDAFNRLSEGAFKGLRRQLPITRQKVEWEKIGAYRLGKDISGGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBD7</accession>
    <name>D4DBD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021463.1">
        <property type="nucleotide sequence ID" value="XM_003021417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBD7"/>
    <dbReference type="GeneID" id="9578424"/>
    <dbReference type="KEGG" id="tve:TRV_04436"/>
    <dbReference type="HOGENOM" id="CLU_091398_2_0_1"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056139" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="81"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="232" mass="26338" checksum="39E8DF653561A99E" modified="2010-05-18" version="1">MKIVILYTLLTLTSLFAVCSSHWNPPVLSRRRLLPRDYRSPKNLDPERNNIDRLNWRFPEDRDSKPQFVMPPSKEAVGGKGVRVSDILGKTREVNVFASMTRGDENISNRLDNDTQDTIVLAPNNVAVQGLPHKPWENPSDYATFGVQEAYEGESGKKRANQNLEKFILAHLIPQRCWEAGKEVRTLGGAKIFWEEKNGKKYIHPGNIEVEDVISEVANGEVWVINGVLNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG0</accession>
    <name>D4DBG0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021386.1">
        <property type="nucleotide sequence ID" value="XM_003021340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG0"/>
    <dbReference type="GeneID" id="9578265"/>
    <dbReference type="KEGG" id="tve:TRV_04460"/>
    <dbReference type="HOGENOM" id="CLU_3335903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="38" mass="4596" checksum="3602DAF0A5E29971" modified="2010-05-18" version="1">MQWFEDVVDGAKKEEEEEEEEDQKRTTKSQKSIKKHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBJ0</accession>
    <name>D4DBJ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZIP Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021416.1">
        <property type="nucleotide sequence ID" value="XM_003021370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBJ0"/>
    <dbReference type="GeneID" id="9578295"/>
    <dbReference type="KEGG" id="tve:TRV_04490"/>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055411" description="ZIP Zinc transporter" evidence="7">
        <location>
            <begin position="31"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="43781" checksum="71C59CBD3B56F559" modified="2010-05-18" version="1">MARSIGFSAFYGRLWRFLAVLALVVVLAQATGTSDKAGTSELTVPQIEEKLQECPLVQSLNAQKLASAPETASLTSRVFAVLFPGSPAVNAILATIYISGPPNFLLALCPPNIDPSSLSIMVAFAVGGLLGDTLFHLLPEIFLGEDSPEHVRFVMVEPNKNLILGLAILVGFVTFVAMDKILRIATGGEGHQHGHSHEHGHSEDSGLVAATGVSAGDGKHGNLKQRKQAAGSAGAASEDKLDTGPSNNPSVKLGGYLNLIADFTHNITDGLAMSSSFYASPTIGATTTVAVFFHEIPHEVGDFALLIQSGFSKRKAMGAQFVTAIGAFIGTFIGIAIQEFGGGGSSSTVSGVASPGLLGTSLTVGDLLLPFTAGTFLYVGTVAVIPELLETGKDNGVETRKTLMQFAAMAAGAGIMLLISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBT4</accession>
    <name>D4DBT4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_04585</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000231">
        <property type="protein sequence ID" value="EFE40691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021309.1">
        <property type="nucleotide sequence ID" value="XM_003021263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBT4"/>
    <dbReference type="GeneID" id="9578153"/>
    <dbReference type="KEGG" id="tve:TRV_04585"/>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="19">
        <location>
            <begin position="561"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="1132"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="829"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE40691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137335" checksum="D9B1F0606BFF7D05" modified="2010-05-18" version="1">MVRLRQIPRSAAFAWSPGHSSPFLATGTHVRAVDVDFSNETFLELWDLKLDGENVGAELQPVAKISTESRFHDLGWAETEDSTRGLIAGALENGALNLWDAAKLLDGSSSEPAMKVAAHSGAVKTLQFHPRHSNLLASGGSVGELFITDLNNIENPTRLGKVAASQVEIDCLDWNKKVPHILATGNSNGFVTVWDAKAGKESLTLKNLGRKPVSAIAWDPEKPTRLVTSIPLETDPVILVWDLRNANAPERVLKGHESGVLSLSWCPQDPRLLLSSGEDNRNICWNPQTGEAYGEFPIVTNATFQTRFNPTNPNILATASLDGKISVQTLQNTNPETAQKGDDAQPLNDEDFFAKAQTQPQGPTFSLPKAPKWFERPTTANFGFGGRVISVVTAPGTRTSTIRISKFEVDASIGAATDAFESALSSGDVRSICESRAAEAKTEEEKSDWKVMTTLMSETPRKELITHLGFSGDVDEAADSLAKLGLKTEESEEKKVEEKEKPSLAPPAGVRKHKRLTSIFDTGADGESDSFLTDLSASKAAQTNSPFQLFTGEETEADKSITKALIQGQFDKALEICLKEDRMADALMIALSGGQECIEKAQEAYFLKKCEGPSYIRLLASIAGKDIWDVVHNADLKNWKEIVAVICTFADDKDYPELCEALGDRLEEYSRTHDSKETRKDASFCYLASSKLEKVVSIWIQELKENESKMVETASGETGFSIHVQVLRDFIEKVTVFRQVSKFVDAEKDKPSDWKLTSLYDKYIEYAEIVATHGRLEVAEKYLSLLPDSHPAGGPAKNRIQLATKKATTKAASKAASHIPAARQASTALPQPSLGGYTPVQPPVPQQPPMMNRGPTPNNPYAPPAFNQPANPYAPSAQTSSYAPTTGYQPTQQPGIAPPLFPGQQAHGVPPPPRGLTQSPSTVKPHTERSNVPAWNDLPEGFARTPTPRRGTPSQGPAVISSPFPNQQQQAQSPPPPPGPPVAGHRGSMPVPPPPKGPFPAASHATPPGSAGGTQFVPPERPSSTANLYAPPPAQHPPTGAAGGPPHIARSASPYTPPPAGAPPSNRYAPVASAQPSHPPGPPGPSGPPGPPQQAPGPGPYGSQRFQPAPPPQGGPPQGPYAPQGGQFTQPPPPPHTGAPPRQDSRPSTGQSQKNAPTAPPKYPAGDRSHIPDNAKPIFEILSADMQRVKARAPSSFKAQVNDTERRLNILFDHLNNEDLLKPATIDSMVELARAIQSREYEAAQAIHLDILTNRTDECGNWMVGVKRLIGMSKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBV1</accession>
    <name>D4DBV1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021289.1">
        <property type="nucleotide sequence ID" value="XM_003021243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBV1"/>
    <dbReference type="GeneID" id="9578134"/>
    <dbReference type="KEGG" id="tve:TRV_04602"/>
    <dbReference type="HOGENOM" id="CLU_056572_0_0_1"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="27706" checksum="C3A31EEB59460949" modified="2010-05-18" version="1">MSQSGSSRQGRRIVIQTPSQNTSRASLANARTGPGTAAGTAPQTSSTHASILKSIRDLHDIHDIHDIQSVRDLNLTHPRTQQDAAPPRPAEGADALWDQMQSALAEVELAATGGSRMFGSYHPEVVESLRAKQLALAQAWGRTEGEEVPNNSSNNNNNSSSGNTAVMEIEQNKPREVLDEKTEKDITHARKRREANDRYFERVSNGVLDVVAKLEDVAETMREVASKSKEIWADSGSRQSPVGSTAGQKVSADADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBX4</accession>
    <name>D4DBX4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000233">
        <property type="protein sequence ID" value="EFE40656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021274.1">
        <property type="nucleotide sequence ID" value="XM_003021228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBX4"/>
    <dbReference type="GeneID" id="9578119"/>
    <dbReference type="KEGG" id="tve:TRV_04625"/>
    <dbReference type="HOGENOM" id="CLU_022511_2_0_1"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="121"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="561" mass="62950" checksum="C66C9EBAE9216011" modified="2010-05-18" version="1">MHEIITLQLGQRSNYVATHFWNAQESYFTYSENEQSPVNHDIHFRGGIGADGTETFTPRALIYDLKGGFGTLRKYNALYQLEEDQPGLDGGLWDTNGILQQQPKIPQIEYQRCLDMGLPVPELTAETVRYWSDFNRVFYSPRSIQQINEYDLGSQLMPFEDWSTGQTLFSDLDREHDLLDRDLRPFAEECDQLKGIQIFSGVNDAWGGFAASYVDRLKDEYGSKSIWTWALNDPSSLRREKRKLASANLARSVSEIGSQVTAFIPIADLPSRLASYVKPDLRHTWYSSALISLALESISLPTRLRGHEALDLWEVASRDSRNIYHLESTVGTQELSGFPTDKGSSGQDTSGSGASHGHDDDDDGPQEKLKQFDVQLSPLGLASTHDSRVFHQLSVRRDRTSDKSSSSSNTGPPVNASSRTQSTKTVASFDTQLEYPILDSFPRDLVAGQGPPGSTLKVHAALSISSQARGYLKELQQSMGIYVPFDQREELSNCLATLSEAYIDGWESDSDSAKAESVFQRIILESNHPPRRRQQRIDIAMKKKKKKKKQMGMPLFLGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCB5</accession>
    <name>D4DCB5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021153.1">
        <property type="nucleotide sequence ID" value="XM_003021107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCB5"/>
    <dbReference type="GeneID" id="9577996"/>
    <dbReference type="KEGG" id="tve:TRV_04768"/>
    <dbReference type="HOGENOM" id="CLU_1295242_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="213" mass="23486" checksum="F9A2BC93B848F71D" modified="2010-05-18" version="1">MLTCHHSIHHVCHLSTAVIVIPSAAGIKGGGKLKTSAAGLWQLSHFHTPIKGHGARLLKYGNFDEKFKRPSVSCIYIAVHGVSVKGEEPLRVPLQLTWPEISSSATSLQASKQRRSEICPTDMSVVLMTANLGVILAFYAHYLRECAFYIGCRRAANEVTINKQNAIHPHQPRHTFSDGPLAASALHPWLTHIRNRVPAESQRPGAWARARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCC0</accession>
    <name>D4DCC0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TRV_04773</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="ACYE01000242">
        <property type="protein sequence ID" value="EFE40506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021124.1">
        <property type="nucleotide sequence ID" value="XM_003021078.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577965"/>
    <dbReference type="KEGG" id="tve:TRV_04773"/>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="24">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="789"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1041"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="476"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EFE40506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1594" mass="181731" checksum="2F896BC8F017111C" modified="2010-05-18" version="1" fragment="single">MPAFRVLLNCVDHYQATPTELDPQFTSDNNDPQLRSGSIKVPVIRVFGATETGQKSAKHRIVNAAIRSLHASIDHALALSYRRNPSDHSAAFVAYISLVKGIPFYGYYVGYRYYFKVYLLNPLHMTRLADLLLQGAVMKRALQPYESHLQFIPQWMCDYSLHGCAYINCSKVKFRPPVPSHISLENPDHLWHDESIPQRDISDPSEFPRQSHCAIEVDIHVQDILNRHEIRQREIHHDFVVESNQGFITEKLVPSLRVLWKDEERRRKAKLGLTGSEGTPFSQKDLASMSSNPHQTHSGGWIHEKEFREQIDAIVAEERRKRDNSPTRSDFVRYPEFHESVKTALESVQELYPQNLLSSQADAIQSQISTEANNGSVEVDENRIDSFGVDTFFDTGDIDDSFARDRQELDDVIGRKLASNTNQPNKSEPLDPNIFLQSSQLEEVGIKRASDPINSESDLFEIDPEFLTLIDSKLRKRDRNEESSPEVSRDKKVKVTEIPQTRSSLKAKFHVSMAGSAQETSIGKGVSSRSDSPASSQKPRASGGDNQRLPFPVVKDSANAATVLRLSQQNLQTKKTQQIFIKEGFLPEGSTSQPNIMNSPNDPKVEPAATNSQDGSENITSYQPPKASKVYCFTQQCPLPSLVRETISDNSRPSVIYQGAYYGNESDVLERALEYAGKEFKLESNSLPFLPTFDPTGTSPAMFGEKPALLLDRTAFEDQNKKLRRACSLRTWEFAVKAPIQSDVVGWFKKEDIQKKRLKNGSADTNARDVPVSQIDTSTQHNKHGFKYSQRTKSSAVQHEANYMSVMSLEVHVNTRGTLAPNPEEDEVACVFWSVISEEEGRHRGVVVLSETYGLSSKLKPEPGIEFQEDMSELDLMNRIVGIVRYYDPDILTGYEVHNGSWGYLIERARKGYDYDLCDEFSRVKSQSHGRISRETDRWGFNHTSTIRVTGRHMINIWRAMRGELNLLQYTMENVAFHLLHKRIPHYPFEDLTRWFKSDRPRDVAKTIQYFSSRVDLNLEILDANELISRTSEQARILGIDFYSVFSRGSQFKVESLMFRIAKPENFILISPSRKQVGQQNALECLPLVMEPQSDFYTSPLLVLDFQSLYPSIMIAYNYCYSTNLGRIVNWRGRNKMGITDYEREPGLLRLLKDKINIAPNGIIYVKQEVRKSLLAKMLTEILETRVMVKNGMKEDKDDRPLQRLLNNRQLALKLIANVTYGYTSASFSGRMPCSEIADSIVQTARETLEKAIALIHSVKRWGAEVVYGDTDSLFIYLKGRTRAEAFDLGEEIAKTITDSNPRPVKLKFEKVYHPCVLLAKKRYVGYKYESKNQEKPEFDAKGIETVRRDGTPAEQKIEEKALRLLFETSDLSRIKEYFQKQCSKIMRGKVSVQDFCFAKEVKLGTYSDRGAPPPGALISAKRMLEDPRLEPQYGERVPYVVVSGAPGARLIDRCFPPEVLLQDPQLELDAEYYISKNLIPPLERIFNLVGANVRQWYDEMPKYQRMRRTEGALNTPAGRSGQDGNNSMFKKTLECYMRSSSCAVCRSKLNSEEQRQQNQAICNVCLRQQPHLSLLKLEYRVHESERRVANLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI8</accession>
    <name>D4DCI8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020978.1">
        <property type="nucleotide sequence ID" value="XM_003020932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI8"/>
    <dbReference type="GeneID" id="9577830"/>
    <dbReference type="KEGG" id="tve:TRV_04843"/>
    <dbReference type="HOGENOM" id="CLU_034953_1_1_1"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="501" mass="54945" checksum="248EB0C902386A93" modified="2010-05-18" version="1">MVGSQVEKKRKRASDRHDRPSKKPAIHSNPEPAKVQYLKNTAGHVPIIASSPGLTVPETLPLNTYIKPRQQRMKHTENANLAMTEALLHTSGHPKLNFTGREGENQLDNLLNHYLAVYDPEDNTVQLLEARKMMIRGCPREAIEEVEEESEGEGTVCLYFYPSVVAGYMLTSWKTQKTVLSQKAALAAAFGTKLARKAVAAITENALTSNASAPSTQAAESALISSMPQDDMTNAAAERSAQAEIQASKPLPQPNLSATQPADVYSIESLVPSGLLTLRKIPVQDWQAAVAASEGITTSSRFVANRVEAAVQSGDKTVVQLLRFILILIEFSRSLKRSPGGGRGLDSRKLPPREDLRRILSTAVYSETNTTPTITDSFLDSIRRKFVPQGSFLSRNDITLLHTTICAMSLHIPPASGKTGGSNVSELATDPADLRDDLRLENDTILKYFRELGCKVDKPRESEFAKWSIKGGKAEAASRRIARLKIPVEFPKMSRGRAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL0</accession>
    <name>D4DCL0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021000.1">
        <property type="nucleotide sequence ID" value="XM_003020954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL0"/>
    <dbReference type="GeneID" id="9577852"/>
    <dbReference type="KEGG" id="tve:TRV_04865"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="631"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="864"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="971" mass="108595" checksum="BEDCC301BDBA2479" modified="2010-05-18" version="1">MALDGSSGYVAASSLDKLAESSLPIFSVKKVQLKFSIAADFVAAQVANDVLILALATGRILRIDLNNAEDIDDIDLPKKSSEIGVIRRMFLDPSASHLIISTTLGENYYLHTQSRQPKLLSRLKGVMIECIAWNPALPTASTREILVGSTDGNLYEVYIESSSEFYRRDERYVNTVYKVPSLAVTGVWVDFVGGRKDLRQIIVSSNGKIFYFTGKIGRHGKDGGGGGSIYIDLFRKETPVIHELTSATLSAPSLLAMQPDPLEEGHSDGRAEEKHFAWLSSLGVLHGTVPNSAPNQDGGSRIFDKAKMVSRSILPATESARGGRKLIQDPIKGMTMTQWHILTLVEGRIVAINRLNGEIVYDQAVLEPGESSLGLVADQKMNTYWLFTGQEIYEISANDEDRDVWRILLKEQQFDSALRYAHGVTQKDAVATASGDHLASKGQYLEAAAVWGKSSKSFEEVCLTFIDKGEHDALRKYLLTQLSTYKKSATMQRMMIASWLVEVFMSKLNSLDDTIATKAELVEGGNEDDAKDDIQSIRSEFQQFVNKYKADLDPRTVYDIIGSHGREQELLYFATTINDHNFVLSYWVQREKWSEALNVLKKQTDPEVFYKYSSVLMTYSASEFVDILMRQTGLDPQKLIPALLTYNKDTKTSLSQNQATRYLNFIIANHPNPSAAVHNTLISIYASHPSTSEGALLHYLESQPSSPPPYDADFALRLCIQHKRVQSCVHIYSMMGQYQEGVTLALKHNDIELAALVADRPEGNDKLRKKLWLLVAEKKIHQPGIGIKEAIEFLRRCELLRIEDLIPFFPDFVVIDDFKDEICTALEDYSRHIDTLRQEMDNSAHVAEQIRLETAALGSRYAIVEPGEKCWICSLPVLSRQFFVFPCQHAFHSDCLGKKVMDAAGTGKKKHIRDLQAEMSKGTSIGAKREKIIRELDGLIAEACILCGEHAIKQLDEPFISPADNKNEWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD25</accession>
    <name>D4DD25_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho guanyl nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000256">
        <property type="protein sequence ID" value="EFE40236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020854.1">
        <property type="nucleotide sequence ID" value="XM_003020808.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577698"/>
    <dbReference type="KEGG" id="tve:TRV_05032"/>
    <dbReference type="HOGENOM" id="CLU_001083_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1457"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1834" mass="202685" checksum="EAD4DA1AE23FE2AA" modified="2010-05-18" version="1" fragment="single">NAERNGRDSPTMSDQENRPPRAYPPLSAAVSHGPSQPHVHHGQQGAAAQAPSQHQQQQHYASQYPTGPHIASQKPPPPHAQMQRSPSYQAGDDTGYFDSRAAPPVAAGGGAGSAYPYHDGRGGSLHGSHSSNFGSRHSQHSTVSQTSSHGSSAMSGYQHQYQGPNTPSPGQQPPSYNPQQFSQQQQQQQQQPPPTPQQAGYNPQVFSQFSSQQPHHQPYNPAAYQSSPSVGSFQSSPAGNWSAGTPVQTSYPSTSPSFFPPSHAVPTSPGPMSARPLDTYNDYSLPYGNNTTHHHPTYPPMPSQSVAATPVSAHPSSYSSYNYPSSNHSQSTTVSYGTEATNDRIRRYSSAKPPAQTSDYQYMPNPPAHGSVHHDAGYRTATRHASYPASPQPPPPPAHQNSQSTSPRRTDTLTRHPQARPLPGPPTESEGQNGREQIEPSYDDIIKQVEAAVMEGRPDTTRRHSSRARRPLPQQPPIQESDDGAYPTSAVSPGVQLLPDEVQTHTNGGNISSTGTGQYVNYNAYSDDSDAEVAAGLEALRVAEEEEAAMRARRNTHTSTTSSFGYQHQEPPPPPPPQNQQHHGESSSDSDFALHDIGLYGGGYSADMHYGEDALMHGVRTSSQPDGRGSTPNQYDYPSIDQDSIHPFPEIEPTARVDTVGTGGLSEPSAYRRMSFENGDEAALRRPSSATSSLSDLPGEGEPQDLFFHPGMSSRPLPPPPVPVATQNLLPHLMPAGTYRSSEHTGQIPLDHYHMPPYPTSPDTYSYSNSTSAVPRSTSLSDHTNTHKSADAIIRSKTDADRAKSKQAAYDSSLSTPSVTLDLPVLPTGKRKKFHPGKLSSEQFRKCTEPWAISAIVAWIRDLAEDEADLKEHSIVDAIVALLTHKVPTMNTADAETLSDRVVKSMFAAGALIKDEEWVKFGPGTLSGVLWQITGQGCYSSRLHNQEYDIFGRCYSHHCMRTLKKINLKMVEAQKKAEDWATFYKIGKEVFSNHSKKEIDRQNNLHEIVTTEDSYIAQLDVLRTLYRDTLATAQPSVINPKRLDRFLRDVFGKVDAVKRVNEEYLLAQLKYRQKEQGPFIVGFSDIFREWIRKAKAAYIEYAATFPNANYLVRREAESNMLFRSFLNQARENRLSNRLSWDTYLKAPITRIQRYTLLLNTVYKNMEKDSEEKSNLLQAIEEIKLVALDCDNKVGEMTKKMDLKELGAKLQLRPEMKSIVELNLEHLGREIIYQGDLQRPRTKRFNWVDIRAILFDHYLVLAKIVIHRDAAGMKHEMFDVSKLPIPMDLLTLVSTNDDPVVRSAVKGIAPANPRAGAPTGLAHAATAPQITSPTPGAAGRSVTTTVLENSRDEKILYPFRIKHLGKRDVYVLYAPTAQSRQDWCEKIYEAKTKHAAALYAQNAEPFRLRVLSDSAFAYSDQAVPPKSAVIKGTPLDRAIREVEKKYERNLSRPLPVCRAAVNCATVFQQPPGKMMCAIGTDYGVYISAYDDPRGWTKGISMLRVTQISVFEEFNLFLLISDKSLIGYHLDSICPVNGAVQPDSQRRAPQKLSGNREVGFFAAGRMKDRALVFYKKRDGISSTFKVLEPVLQKSSSSRSRFLSRRGQTEFFREYDEFYIPAESYGINLFHTSLAISTSRGVEVLTLDKKQPWSVPNLKSEQADVQSHLTSIANRVKDLRPLGMFRLSDSEFLVVFQECAVYVNKHGDVSRSVVMEFVGIAHAACLCGKFLLLFNEDFVEVRNAMNGRLRQVIAGRNVTLLDDGGNGNSGIDQHTNAVGGSNFNEAASTPTGTGRNGLGISTGFGTISRTVKICMQHPERERSQIVLELLENEGQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDG0</accession>
    <name>D4DDG0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020720.1">
        <property type="nucleotide sequence ID" value="XM_003020674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDG0"/>
    <dbReference type="GeneID" id="9577419"/>
    <dbReference type="KEGG" id="tve:TRV_05171"/>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="116" mass="13265" checksum="AD6C688785FADD4D" modified="2010-05-18" version="1">MSYQKPEKEFGEGPKIHKIRITLTSRKVASLEKVCQELIDRARSKSLFVKGPVRLPTKTLRISTRKTPNGEGSKTWDQYEMRIHKRLIDLHAPTETVKQIIINIEAGVEVEVTIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDG9</accession>
    <name>D4DDG9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020729.1">
        <property type="nucleotide sequence ID" value="XM_003020683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDG9"/>
    <dbReference type="GeneID" id="9577428"/>
    <dbReference type="KEGG" id="tve:TRV_05180"/>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="340" mass="38467" checksum="B4F81AC3991AC7A1" modified="2010-05-18" version="1">MSFDSIPILDLSAARDAATKPGFLDELRHALLEVGFLYIKNTGIDDKLIEDVIAEGKKFFDLPMEKKLEMEMKNAPSFLGYSRLGGEITRFKTDWREQIDLSTNHPVPGPSDPLYHNLLAPNQWPDESSIPRFRPVYEEYMEKMGAISMEFISLVAEAIGLPANAFDRFFDKDQQHKLKIVKYPDLEELGVDGEAQGVGPHKDSMLTSYLLQATKHRGLQVQNHRGEWIDCPPIDGTLVVAMGQGLEAITQGVCQSVPFFQGVSYDATFESMDVPDQVKKLRQEVVERNGIRQDDIEFTFSKGRWGHLGEAALMNRIKSHPDVGERFVSLRDISSMIYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDH3</accession>
    <name>D4DDH3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020733.1">
        <property type="nucleotide sequence ID" value="XM_003020687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDH3"/>
    <dbReference type="GeneID" id="9577432"/>
    <dbReference type="KEGG" id="tve:TRV_05184"/>
    <dbReference type="HOGENOM" id="CLU_017452_2_1_1"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="316"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="588" mass="66091" checksum="AE5DCC49480820C4" modified="2010-05-18" version="1">MGINSEANGPSCSLPAVIGKQETRRLPVTLLSGFLGSGKTTLLEHILKSPDHGLRIAVIVNDMSKLNIDAALITHHKVSQTKEKLIQLQNGCICCTLRGDLLSELANLTKQNEVEYVVIESTGISEPMQVAETFTAEFSAAMLEAEDQIADADEDSKKILAEIAELGGLHTLASLDTTVTVIDAFNLLSNFDTTEFLSDRYGAKEIVPEDERTISDLMVDQIEFADVVIINKIETVNEDTRRRIKQLVNLLNPEAKVLEASYSKVDVREIIDTKRFNFLKAASGSGWLRSLHEMTIMNTGNGQRMAPKPETLEYGINNFVYTARRPFHPRHLFALLHDKFILLQHSEGGDEDEDNEGNEDDKMDLDEEEGDEGDEDTEKQGVSGFEQPDPAVILANKRSHVFGPVLRSKGFFWLATRPLQFGEWSQAGGMLTVSCGGPWFAEVPSDAWPEDEDVRKSIENDFKGDWGDRRQELVFIGEGIDTEKITALLDNCLLDDKEMARWERVMGNKELSRDEKAELLGTMWEDGWEDWPPFEIEGEDEDEEDMEETKPKHYISDYLGPAKKDGHKHHHHHHHHKNGERKKSAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDP4</accession>
    <name>D4DDP4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020657.1">
        <property type="nucleotide sequence ID" value="XM_003020611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDP4"/>
    <dbReference type="GeneID" id="9577356"/>
    <dbReference type="KEGG" id="tve:TRV_05255"/>
    <dbReference type="HOGENOM" id="CLU_052850_0_0_1"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="47134" checksum="3A41F09B991544A3" modified="2010-05-18" version="1">MDSSSDRPSSLASIEHLSSSLPTPQPWANQSLSTLGTRGRLFNPALDDPTLARRTTALRQLHGITRPPQRKHRQSASIASRASLSSQPVIVRTYSGGPERESTMSRRRSSDREQQTTNAPPARLPSVDEFGIEGILQSIEPNIQVTLDAIAEICGRSKLSLANEYGSHRPPLGEIRAPARTSDHGLLTVEEASSSTERLADDNVLVVGDDISTVDGHGRYSSTYDYLNPIPRPTGLFDFRNSLPQAWAETNTTQQQAESHRHTVRRELVPAHEETIPPTRNHHPVDKGRLPYLPWALDTRLESGDYNATGQSMMTRPVISAVHLDAQADRSYHLTEPDRPWPSTDAIVDIPDYDELPHINGHKQKSHSRKSSVLDELQGFLSWVGKMSRAHGKSSQEVTSLVSAQEKLRDVLEKQNARLSHLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDU3</accession>
    <name>D4DDU3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000272">
        <property type="protein sequence ID" value="EFE39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020603.1">
        <property type="nucleotide sequence ID" value="XM_003020557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDU3"/>
    <dbReference type="GeneID" id="9577299"/>
    <dbReference type="KEGG" id="tve:TRV_05307"/>
    <dbReference type="HOGENOM" id="CLU_006308_3_2_1"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="688" mass="78437" checksum="255FE512363234F8" modified="2010-05-18" version="1">MADTMAMQSAVRLPTPPPGVSYSPRASVPRKRSPTSRSPSPDRRRRAPAQDDAENGQYEPDAREKELAERFRRTQRPAASKPLTEEEKQAAAKAEYEKLLNMRSGGTYIPPARLRALQAQITDKSSKEYQRMAWEALKKSINGLINKVNVSNIKHIVPELFGENLVRGRGLFCRSIMKAQAASLPFTPIYAAMAAIVNTKLPQVGELLLHRLVVQFRKAFKRNDKAVCISSTTFIAHLCNQQVVHEMVAAQILLLLLHKPTDDSVEIAVGLTREVGQHLEEMSGPIALAVFDQFRHILHEADIDKRVQYMIEVLFQVRKDKFKDNPAIKEELDLVEEEDQITHRVGLDDEINVQDGLNIFKFDPQWEEHEEAYKKLKAEILGEGSDDEEEDDSEASSEEEEDEEEKEMDIKDQSNTDLVNLRRTIYLTIMSSIDFEECCHKLMKINLPTGKESELPSMIIECCSQERTYSKFYGLIGERFAKINRLWADLFETAFATYYETIHRYETNRLRNIARFFSHMLSSDAIGWHVLSIVHLNEEETTSSSRIFIKILFQDLAEVLGMTKLQERLRDPILLPSYEGIFPTDNPRNTRFSINYFTSIGMGVLTEEMREHLKNIPKPTVPAIQAPESDSESVSSYSSYSSRSRSSRSRSLSRSRSPSRGRRSKPFSETPQELLQVNITNPSSTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE56</accession>
    <name>D4DE56_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000284">
        <property type="protein sequence ID" value="EFE39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020490.1">
        <property type="nucleotide sequence ID" value="XM_003020444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE56"/>
    <dbReference type="GeneID" id="9584228"/>
    <dbReference type="KEGG" id="tve:TRV_05422"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="31746" checksum="A8F0EDAE847E4825" modified="2010-05-18" version="1">MHDAGLDYFGRKLATCSSDKTVKIFEIEGESHKLLETLKGVYQQAHPKYGTILASSSYDGKVLIWREQSVGSGANSSTSWSRVFDFSLHTASVNMVCWAPHELGCLLACASSDGQVSVLEFRDNSWTHQIFHAHGLGVNSISWAPAAAAGSIISTNAAAGQSRRFVTCGSDNLIFIWDYNPETKTYSASQTLQGHTDWVRDVAWSPSILSRSYIASASQDKTVRIWTSDPSNPQEWTSEKLEFDTVVWRVSWSLSGNILAVSGGDNKVSLWKEDLKGKWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE99</accession>
    <name>D4DE99_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_05466</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000288">
        <property type="protein sequence ID" value="EFE39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020446.1">
        <property type="nucleotide sequence ID" value="XM_003020400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE99"/>
    <dbReference type="GeneID" id="9584181"/>
    <dbReference type="KEGG" id="tve:TRV_05466"/>
    <dbReference type="HOGENOM" id="CLU_045138_1_0_1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000017">
        <property type="entry name" value="Phosphatidylinositol transfer protein sfh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="362"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="449" mass="49267" checksum="43E814EF075E3453" modified="2010-05-18" version="1">MDKTQEKVEQPVAQAEAAAAVEAEKVEKAVEKADEKQVEEKKDAEQAPSKPAEDKKDAEPAEQVKTEAPGAATAQDKTEESAPADNRPEYLTKHAGLTQLFDRLPAILEATGHNEMWGVTLKDTEDIPTVNIMIKFLRANEGNVKAAEEQLTKALEWRKEMKPLEIVKNMKFSAKKFKNLGFITTYGVGEAKSVFTWNIYGAVKNIDETFGDLKGFIKWRVALMELAIHELNLDKAKTVIPAIGEDPYQMFQVHDYQNVSFLRMSPTIRNASRETITVFSMAYPELLREKFFVNVPTVMGWVFTALKVFLSKNTIRKFHPITNGSALAREFGEAGAEFPKSYGGKNAELAESSMTVALIDDISQERETKAEPKTETGAETKAETKAEEPKAKEAPETKPEEAKTETPTAPVPENTISEATDKPAGEANGAPKVAGETVPAPAPAAAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEE5</accession>
    <name>D4DEE5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020394.1">
        <property type="nucleotide sequence ID" value="XM_003020348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEE5"/>
    <dbReference type="GeneID" id="9584120"/>
    <dbReference type="KEGG" id="tve:TRV_05512"/>
    <dbReference type="HOGENOM" id="CLU_010672_3_0_1"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="86230" checksum="1F3CE99284357541" modified="2010-05-18" version="1">MANEAPVGSREEALLQQLERERALRRQAEDEKERAERDNARLQKQLQPTTLPEFLDACHVYLSVGFSSRINYKTGTQGNPENAYLKLRPDYIREWTTFSQEQSEVWRDLFSVDFASEPHFTSLNTLKEMGNDLQVRSMGSELDLNYYERYAVEDRVSLIIRNLFSDDRLRKIFNLGGDVTFENHGNTITTEERGAETTANPDIGSPQQSPVQKRRKKADMHGDSLPATPTVRSRSSRPRADQFCVYNTGPERAIPAFIIEYKAPHKLTLAIIEAGLMEMDVDDVVIYNESDDPVKLAQRRVAAVISQAFSYMIQAELEFGYVCTGEMFIFLRVPSDDPATVYYYLSTPNEDVGETTGWAGEDSANRLHLTAIGQVLAFTLRALKSPPRGQVWRNNAEAQLKRWEIEQDDILFGLDIEESTGKKLSDYKQDRKSRNEYIRVSPIKTRSKSKGLASCRDPERPRGSEPSDDGDDDDSSGSGGFDPGSPSSGLPRRASNVTAVTKPPPTGSREHKYSMEPPIEPTQFCTQKCLLGLFNRGPLDQNCPHVANHGVERHAIDDREFRRLVRAQILADSGPSGCESMHLHGTSGALFWLTLFPYGYTLVAKAMPVETVKCALYEERIYQHLRPIQGIYVPVCLGSVDISSRPLWYDGIFEVVHLLLLGHAGRLVKFHAGANNLRDFAPSACESLRAIHKQHALHRDAHSGNMFWNAENKQVMFVDFERARVVNSRKTKKRKRGALPLSSHGNTEFEREIKSVERHMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET7</accession>
    <name>D4DET7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020238.1">
        <property type="nucleotide sequence ID" value="XM_003020192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET7"/>
    <dbReference type="GeneID" id="9582779"/>
    <dbReference type="KEGG" id="tve:TRV_05677"/>
    <dbReference type="HOGENOM" id="CLU_018589_0_1_1"/>
    <dbReference type="OrthoDB" id="5405297at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="589" mass="66641" checksum="F5A52999C6F992F9" modified="2010-05-18" version="1">MGFFKRLRAKTRSRGGKRDLYGEQDQDQYQPYAQYQQQPGGSFGRRPARDYTKTLPPNVLSNIFYQVCPHSRDTSLTSSEESMTEDGCMLCDMRDLAHAALVCTHWYGIAQNILYVHPTLGRRVCLFKNLGTNKQKWTTRYQHIRIDAVHYCELEIELAAKRKKNSFLNHNAEPLDAPRTRLLLFMRTVRDSRALGSMVKSLRMPYMTREASKSELARTISVLPNLRYVDLPAGFFSDDASSLTLKQELLARCPDIRRMKFAKGAESSFSRLPKVKGWPNLEVLELSGLNIETNLLRMILGYFERLTDLRFEDMPWLEDTVFKAVPTLPPFPALQRLTLTDTPKITSRGLTWYLSNSSSSQQTRSALRHLSMVNTGVEPQRLHEVLAQAPLLSSLSMQQEVTREFPPDYVPPLTSNSLQLLHYEITSETGSSSFGAQALSTSYYTYLMSSLLMGSLPNLTDLYVRDANFPETLMLAPPPPVFGDPSRQSQANVGLNQALSVYSKGMDELEWNFTTYQPFAEAGRRMSTTRPVSLHGAQLSPAWGGEARRSVLVGNGFGGFLAVPAEEERRPSTSTRSSGGRREKRDLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEZ0</accession>
    <name>D4DEZ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000316">
        <property type="protein sequence ID" value="EFE39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020203.1">
        <property type="nucleotide sequence ID" value="XM_003020157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEZ0"/>
    <dbReference type="GeneID" id="9583973"/>
    <dbReference type="KEGG" id="tve:TRV_05731"/>
    <dbReference type="HOGENOM" id="CLU_023620_5_0_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="113"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="56034" checksum="9B02085FDF318F20" modified="2010-05-18" version="1">MASGKMEEPPVSWSSAANTIPHYDGPPRNIATIDALDFGVHLTPKKYEMAGTHPDSKIMFLDVEILDSTGKLPYRGDVLIEGERITAVGNIPGKEELKKNPRVRKILGRGRTLMSGLGDAHTHLSWNGGDLERLGELAVEEHTLLTARSAQCYADSGYTMCFGAAAAKDRLDVVIRDSINDGDIPGPRCLANGMEIARRDGELVAGITAFADGPEEMREKVKHHAELGVDQIKLSMSGEEITETRSAQDCYFTDEETAACVDEAHKRGIRLCAHARARDSVKMCVKHGVDVIYHASYIDDEGMDMLEKNKTKHIVAPAINWLVNIFTEAAKFGYTPEKAEEVGYRKERDTAILALREMHRRGIVILPGGDYGFAWTPHGTYARDLMHFQELIGFTAHESVIAATAGVAKLFMREHELGKILPGYYADCILVDGNPLEDIAVLQDHAKLDVIIINGRVHKIGKKDGAGRVPLSANPESNGHANGAGNDIPDGENVHHEEFPEIKKSMQKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFD3</accession>
    <name>D4DFD3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020106.1">
        <property type="nucleotide sequence ID" value="XM_003020060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583870"/>
    <dbReference type="KEGG" id="tve:TRV_05880"/>
    <dbReference type="HOGENOM" id="CLU_003143_1_0_1"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="974"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146286" checksum="FEF49E1122383BBF" modified="2010-05-18" version="1">MGGKASQPAAVSTSISSEGHSSRLPASLYTTVRTCSLSYVFIKEPEVSETEWELTWSLVAGLFASLSLSFCPSVLLPVSGLPPTFMPARLYSQHRRLPASWVSFSLAFSSHLFFFFFFFFYLSLLLLSFLSCSVTFPTLTNVTSGEDDGTLSCSLILSEDPKQSVDIEFMVTDISLYPKEHEFLIYTTSEDVPQYVTEVLEQAQQAISRLEIPDMLSQLSYTFQNKIEPEDDGQCDFADDLFLNDDEDSVYSGIEDAIPDLNDDEYHWSPVPQQTQLTHSDTITEEIQDSEELLCKISEDLKTAKLAGFRVGYLGNKLCPIVSVSCRISKLGISEDAMKAWHIKEEQYLVCLIRYIGKYQSLENLLLEDELSGKSSVEMFDQVGQGAKSRIAICGNSPPNNDDITQFWSNLVWSRTVFNECQGKPVGSSDPISHIYQEPDISEEKAAMLPRALSADHLLEKNGSGASFPLIAMQFMLRHFVRCTEFCLVCHCKTNDNFEALKPYVCSKSLCLFQYMTLGFGPSLEWEIMTQPYVVDLLVSFTYSSAIRSRLVDPPTGLGIMVPGGMHDANYKNLCNDAAESTAISHREIRFEVSFDESSMTMNFAGSVPGHRVCTGDWLVIIDEGRYLHCRVTNTSFWPSVDISSPIKVSKSREAIEDKTMPIPKLVKAAWYGQNFDDLSPKAQHQMVVSLLDTLPTVVEMKQYLMENSRGSQPTLTQWKDRISKSALDLLRWIVASNRSCIIQDDPDPTEDSVNADQANDDRVGGVPGYMQFRFAQGAPDKEERFFKAVMAKNKNFIHPHATIFAWHGSHLSNWHGILREGLHFKEIMHGRAFGDGVYMSTSFTTSAAYISPNLGLSFGSPTETWPNSKLGVTGAISLNEVVNSPSEFVNTSPHLVVSQLDWIQTRYLFVRCSLNKEIGLNSPSKLLPYYHQDPKYVALGPNYKTITIPLSAFSQKRRLALGMTAVSHPPASTPTNLSTKQGNGVASSSTKRANSISKSPIPRSQAAQGPGSTSGSANSHAGVTARYYTDNTTSQQTAGLFTSDKPNHAESDGYLSDETDVDDLNIHIEADSIRSKQARGNNPEQAPEESGTKGKNKAQNETDFIPGTLDPASLPMIAAPDNATPSATASLQRDLRGALRIQDNEPLADLGWYIDPNLVNNVYQWIVELHSFDPSLPLSKDMAKAGIKSVVLEVRFPQQYPMSPPFVRVIRPRFLGFQQGGGGHVTAGGALCMELLTNSGWSAVSSIESVLLQVRLAISSTDPQPARLVPGQDARKGRVLEYGVAEAVEAFIRACKAHGWQIPADFHRESKASLAAEASSYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG47</accession>
    <name>D4DG47_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Malic acid transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000346">
        <property type="protein sequence ID" value="EFE39180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019804.1">
        <property type="nucleotide sequence ID" value="XM_003019758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG47"/>
    <dbReference type="GeneID" id="9584555"/>
    <dbReference type="KEGG" id="tve:TRV_06149"/>
    <dbReference type="HOGENOM" id="CLU_030057_5_1_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055552" evidence="9">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="24240" checksum="6727D2B74B4A75FC" modified="2010-05-18" version="1">MTKHTSSLETMTAAWLLPIVAPVVAAASGGVVADSLQNDTHALITILVCYVMWGSAVPLAMVILVIYFQRLAIHKLVPRAAIVSALLPIGPLGQGGFGLMQLGVVAKRVFPRLDFLAPIAGDIFYVMGAFIAMIMWGFGLIWLWFALASFTRGKFYFNIGWWAFTFPLGVFTTATTQMGKEFNSPFFDILGTFFSIVVTCMWVLVFALTVYKSCTKELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGB1</accession>
    <name>D4DGB1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000350">
        <property type="protein sequence ID" value="EFE39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019732.1">
        <property type="nucleotide sequence ID" value="XM_003019686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGB1"/>
    <dbReference type="GeneID" id="9583654"/>
    <dbReference type="KEGG" id="tve:TRV_06215"/>
    <dbReference type="HOGENOM" id="CLU_054787_0_0_1"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="47467" checksum="0A114237D4415AF4" modified="2010-05-18" version="1">MVPLAREAPLAIKPPAASAAAKSLLASAPSPGSNLTPPLTPVEEDDGARIIPVLDGAHSTVPPLWAAQLDGPSECSLPLKYRYGQDGSRIEYGRGAWSNVYSAISIDHAASLAKSPPQTPTRGSLASSPMLGPRNGHTSSRSSSSSGNTHTTVYAVKVASGRLAHDAVAAEADILTFLHRIPGSTAHVVPFHGYIASEHAIVMTAIPLSFASYIKTRAKDAAAVFNTRTMFKPVLGMATWLSFADKLVEGLRWMHEAGVVHGDIKPQNILLRPRVPSISISSSSSSSGGPTATALNSSGTIDDTAANSFDLLFIDFTSSLYSHGSGVALNSTASSRLATSLPFTAPELLSISSMTLPPTPAPSSDIFALALTLVAAAIGYGEVYPGLERHRALALARDGHRVIDYVRAGEQGTRIPRKGVVERVISPAVLKDAGSRVATEHWLGIIRGEIAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGL4</accession>
    <name>D4DGL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019647.1">
        <property type="nucleotide sequence ID" value="XM_003019601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGL4"/>
    <dbReference type="GeneID" id="9583547"/>
    <dbReference type="KEGG" id="tve:TRV_06318"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12287" checksum="54DB81310F02E5C9" modified="2010-05-18" version="1">MNCCDNSGARNLYIISVKATGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWKRPDGVFLYFEDNAGVIVNAKGEMKGSAITGPVGKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP7</accession>
    <name>D4DGP7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019634.1">
        <property type="nucleotide sequence ID" value="XM_003019588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP7"/>
    <dbReference type="GeneID" id="9580164"/>
    <dbReference type="KEGG" id="tve:TRV_06352"/>
    <dbReference type="HOGENOM" id="CLU_039755_3_0_1"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="47355" checksum="2616760372CF8A03" modified="2010-05-18" version="1">MTTHGPNEEFVCERRRELLSSLQDLLRRIHPQGISSTTWAGLWLADIEILEALLDPNQRTELFKLLNHQTENVALLWQQLDPWKSRSPSPSAPQSPLASPRGTPSQSSPLHRSTIERQAGLHRDVHEDEQAPQPTSQPATPPAKRQRRDSFRSSTARRQCLFRDENRCLITKSLDPVDAAHIFPHSLRNSFSIDNNKHRFWVLLQLFWTERRVNTWMAAAFPRGTTEVVENLLCFAPTIYRWHSKGLFGLQPIRRSDDGKEFTVKFYWLPLRKPAAQGVDLLTDPTIPEDLVGIAKDYRAWNTFTGEEIASGREIVLTTRDPENLPLPSWDLLDLQWTLQRLVALRGAADVFADTIDDDDSSGIMWEDEDENVRHRDSIASSSDQEIEPLSLSPQAPKVVSTTSNVIDAPADDQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHI4</accession>
    <name>D4DHI4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019359.1">
        <property type="nucleotide sequence ID" value="XM_003019313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHI4"/>
    <dbReference type="GeneID" id="9577681"/>
    <dbReference type="KEGG" id="tve:TRV_06640"/>
    <dbReference type="HOGENOM" id="CLU_1054453_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29543" checksum="6F3EE91D22343205" modified="2010-05-18" version="1">MQLPPVSVIASWPKPNYDNPPEVHGPAIIIMTAIFMPLMLAIIGIRIFTRIRILRSFGWDDIFIIAAALPTLGCGIITTTAAITLGWNRHIYDVQESGCTYKLLFNGILFKPNQTQSNPLLVYNAAQSNKLLSRCLQRLFRGFLSRRSAQKPTFAEAEKGEKENAEGELSRCDIQQFMFMFIRLATDSVTPEDLSWLGPMSDQRLRPAYENQPAGKASSPAWLPSPPIPDLKLPARRRQKAQPPLHCPASGLAIEADQPHRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHR3</accession>
    <name>D4DHR3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000384">
        <property type="protein sequence ID" value="EFE38612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019257.1">
        <property type="nucleotide sequence ID" value="XM_003019211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHR3"/>
    <dbReference type="GeneID" id="9577495"/>
    <dbReference type="KEGG" id="tve:TRV_06720"/>
    <dbReference type="HOGENOM" id="CLU_075469_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="28744" checksum="B0703332F82963BF" modified="2010-05-18" version="1">MQQPSTPGSDAEIGTFTSSGSNTDGQNRIQTSSSSNALQETQASLNTASPRASVVDASSSGSEQPSAAEVKTIKRACAASILALIPRRIALTLFATHQTDGNSSPAAASITAQDKPDPFVQSSVPESSVNSRIDSPLSGAGSEPGLANNSNPSRQDGRHGGPGTHRQTLPAQSSHDRNARDGKATDDGPDLPKSPSGKESKDYKDDEDDALLSAIEHDLLDLFSDSYCNKHLIYSIVELVLVKLIPEMGEHSVTELMNERGVLWSTASTTTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI27</accession>
    <name>D4DI27_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019150.1">
        <property type="nucleotide sequence ID" value="XM_003019104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI27"/>
    <dbReference type="GeneID" id="9580098"/>
    <dbReference type="KEGG" id="tve:TRV_06834"/>
    <dbReference type="HOGENOM" id="CLU_044389_0_0_1"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="404"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="53933" checksum="FD9F224BEBAAA6B6" modified="2010-05-18" version="1">MRAQQLAAPSPEDGELPDILIFKYQNESWSFEFPAFSIDDDRLCVSDIRRLAGQTLNIADISRIKLMYKGRLMTDDAASAKSQGLKQFSEVVAIVMPGYTKGVYGGSSGLIDGWREAQLIPVSDSEEDDEQPSLRPPPPPPLQKSQQQQQQQPSSSSSSSSSSSASRPRRPPKVKIEVRDDDESEDERYYYKPSPVRRGRSPPKYVPQERRKSVRRERKPRDPSPVSPDRKPRRRPVQQQQQQQQQQQQQPPVQPVQPVRVPVSAKEPISPREKIYARQTRPPSPPKSKYQYPAVPPYPSPPPAAYDPLPNICREPRPYATSHPSPSVSSTVSSSTYTSDSASTAASTAASVSPTVPTSIPTSTKPKPKPKANKTYSVPNRPPTPCPPFLASHSTSDKLTIFEKYVTDKLIPLCTRFIMHPPADARAQNKEQRRLSEAMERVLARADEITVGSSRPLRDRRKAAVQMVQRFQTRIDAMIVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DID6</accession>
    <name>D4DID6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019043.1">
        <property type="nucleotide sequence ID" value="XM_003018997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DID6"/>
    <dbReference type="GeneID" id="9582451"/>
    <dbReference type="KEGG" id="tve:TRV_06944"/>
    <dbReference type="HOGENOM" id="CLU_007946_13_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF35">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="18"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="545" mass="61242" checksum="AFC5AE844E67DA8A" modified="2010-05-18" version="1">MVSRLCQTRLIYRHLALTLVTGLFLGSGRSLAGAGPGGAVLCYLLMATVISSVISCLGEMTALMPVNAPVMEFPRRFVDRGVGFAVGWVYWFAYAVLAADQLVAVTNSVRFRYDDGKTFLHWETGENVHPAVWTSLFLFLVTMINMLPVKVWTTMIFYFTIVIPLLTARSNAYYKDPVGTKYWDQPFSFICRDYKVRGEDNTVQMEIKGTMVRTTIINVIFSYVGMDIVAATAAESKSLADSESMKMAARKINLRVITLYTLAMLTASFLVPRNHPFLNGKAQSVGSSSVFLIAVVEAGLPAVAHFFNAMYVFSAFTCAINSMYVASRVLHTLALREQTGPRWLTRRLQECHLGVPLRTVFATAGLMMIAYMGPTGGPERKYFCCNNLGYPHWSKLYTNSCISRLDEAKTLGNTSQAQSGCYERDHPRYPYKSHGQWLKGAYGLFSCLILIIFNGVGAFLETPFNVRHFLAAYIGVPVFFLLVIGYKFKKHGFHFSRWGPERSNDLQNTVQVTSKTRKGRLEFPDDGFTAENGKTFVKWIWTWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DII7</accession>
    <name>D4DII7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018984.1">
        <property type="nucleotide sequence ID" value="XM_003018938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DII7"/>
    <dbReference type="GeneID" id="9582308"/>
    <dbReference type="KEGG" id="tve:TRV_06997"/>
    <dbReference type="HOGENOM" id="CLU_023256_0_0_1"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="610" mass="69473" checksum="6F240333AEE726C8" modified="2010-05-18" version="1">MTWTLEEAVEQLESAVAELVKVIVSSAFDSGLKTNILDHILNVVVSSRHLDQSIVTSIIKNLYPAERVPAKVVSRVICSLGATKSKPSPATQNLLLRWLLLVYDCLVNQIHLEKFYSILFDNLDMISLRRPICHLLSLITRRKHVKPFRVWALLELIRNTGGDERELWGLLRVYKSYYPDIIVDDTAIPRRRATYFFKHPDQEWTAHMKLLQERAANTAPQIAPEAFQAIRRDGVKRSRIEVVIPVPKTSRVRRGFTSLEELSNVRDFVKKLDKIELPNQIASALMEPLSQKFLLLVQNKEALQRMESWLTSFFEDELDQLREENASSEELGFVLDSLVRYVRYTKAFPGSLDKFLQHYLPVWDGTSHRATVLRLLEYAPLRDDTLRQYFLPLENAILDNTMESKSLVLQYYTALIRRYGSILRSKTSVDQALDLVSVVQRAELMSLTLMECPATCGANPAKDSRPSSSPVMQFYTQLAELYVHAPTNPLIRLNTPPPETVYLLVFTPVLSHMSLMSNVIAIYKSSFEQSLATTASAGDAPRQLYADAVVASLNGYVLDICNLLWRNRGLNGDEPNALGCLVRSDVVELLTEYIQESLLLEKTGKRYWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIJ7</accession>
    <name>D4DIJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018994.1">
        <property type="nucleotide sequence ID" value="XM_003018948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIJ7"/>
    <dbReference type="GeneID" id="9582318"/>
    <dbReference type="KEGG" id="tve:TRV_07007"/>
    <dbReference type="HOGENOM" id="CLU_061193_3_1_1"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="27921" checksum="0A65F3ADDAA32B11" modified="2010-05-18" version="1">MDLVSTIRKEGSRGGQTEFKWSDVKDSSRRENYLGHSLMAPVGRWQQGRDLSWYTKGEDSDAAKKAREEEIRKVKEAEQEAIARALGLPVSVPSKSSNANLEPLGGKEVERAVLEGADDHEDVDRVKGVGFGGFTATTVKLQRPMLTTGPAVTATRKEERNTAEETVEIMQGTIEAGEKITAQIDMKEKDIVHVLGPGPERPLGGNAQFHVHAAEIGKHEIVEAIADGADHPMTPDVIETINDMNVTTEDDNTAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIK3</accession>
    <name>D4DIK3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019000.1">
        <property type="nucleotide sequence ID" value="XM_003018954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIK3"/>
    <dbReference type="GeneID" id="9582324"/>
    <dbReference type="KEGG" id="tve:TRV_07013"/>
    <dbReference type="HOGENOM" id="CLU_1644948_0_0_1"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18835" checksum="C4CFF4BC14587D50" modified="2010-05-18" version="1">MEAFDWLYGNEKRRVEESREEAESCWHGRISQSYQHLRPHCQVNTPGLHISTLILNQEPGNMFSSILRRLQGGNLEVFKFGLYIGFPIGWMYYFGTNLEERFSVPDFWPTTAHSHKIPADKGEIDKELARMNEQRAKRLLEKQRIQKEFENIAATSNSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIL7</accession>
    <name>D4DIL7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">75k gamma secalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019014.1">
        <property type="nucleotide sequence ID" value="XM_003018968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIL7"/>
    <dbReference type="GeneID" id="9582419"/>
    <dbReference type="KEGG" id="tve:TRV_07027"/>
    <dbReference type="HOGENOM" id="CLU_006541_1_0_1"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="94945" checksum="E6877C3676D588CD" modified="2010-05-18" version="1">MAYRQNGQYPPSQSPRQPYPPATPPQQSYHQSPQVYPQVVIPAYPPHLAQSPLLQPPIRPHDFTTSAVSQQVPPHYPAPPHANFQYGGVSATPGSPYAMPNRHPDSYASPHSLYPVTLPPHSQTQVPPRPSQPVPQRPVSQPVSQPVSPQVQSLPHTQGYSQFPTQPSPTVQNSHNIPKTAKAPTPRPQARPSPQMTGTKLSQQQKQGGHDNSKPHVDYQVLLLALADEYLDAAHSQATLIAVSQDEHETEQYYKLIATGLRCMEALLKNWRLAPQTEALVTLRFAKILYEETNNDTVAETILSKGNRMFDLKYGMQQLLCRIVSKSNPRAAMKTVDGVIRDIETYRHTGWEYAFRLLRASISLSPPPHQDLVGALHNLQKISSLAASCGDKAVSTIAAVLEALIHLQQSTNADSIEHAQRAIATARSRQLDPEIRGIPQLNSVIQMIDICCSVLEYDTNQSSQKLKEMQRSMDQDIHNPKWKDDGSFALPLSAGTMKSASPREPRHDGHIFELTMSWLPEHDLYALCYFLSSVTLSAKNSQDGHKAEKYLEEGLGMMKAGLSSPQGISESLVASSSRIHWRRSLYCNMLLQQVFLFCSRTEWRMANKTLKEVRSTLAELGDSVGDDIRCLAEYARGIIHQAVGDIEAAMATFHQPMFSLSQATSKIPRSNPHRDTIILANLNLVLLLRDPSKADHSLASETLSILGPHCQNSPNKYIRAAHSLISATVHTESTIQTKRDLHQALQAATAIQNCQITCIALTFMSWKYFRGVIGEQSEKSAMAARAMARKADDKLWMSVTDDLLAETLDRQGKSADAQTLRAKADKKLEALPPALKMNKPDGTGNGNLSTNGGASKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIQ2</accession>
    <name>D4DIQ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018930.1">
        <property type="nucleotide sequence ID" value="XM_003018884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIQ2"/>
    <dbReference type="GeneID" id="9582090"/>
    <dbReference type="KEGG" id="tve:TRV_07062"/>
    <dbReference type="HOGENOM" id="CLU_1185769_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="234" mass="26079" checksum="C0BD25814F1F64A8" modified="2010-05-18" version="1">MPQSGILELLFIEQTLQRENGDRRRQLLLSLGRRREPAKSVSHDHLGCLSKHVTVSPHSFRPWHVVRSASEKAAHRGHGEQKQKKAEAGGVKEAAAAGEGRKAAERERERDGEELLTSIGSVKAAFYFFSVNFNFNFNFSYSPPPPLSPAPRSALCLFISFFSLPLSSPCFFFTRPVSLFLRVSVFPSCVLSFCSFVSYFFLSVLLSLLTLSSLLFSLLSLGSLYISLSPRPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIX9</accession>
    <name>D4DIX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="ACYE01000417">
        <property type="protein sequence ID" value="EFE38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018823.1">
        <property type="nucleotide sequence ID" value="XM_003018777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIX9"/>
    <dbReference type="GeneID" id="9581385"/>
    <dbReference type="KEGG" id="tve:TRV_07142"/>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="63643" checksum="DFC3B01B9F34634E" modified="2010-05-18" version="1">MDALITAELAKLDPSVPFRATKSHLHHTWAKTFYSRPELYIQPESVAEIEKVITLARRCRRRIVTVGSGHSPSDLTCTSSWVVNLDNYRRVLSFSRDTGVVTVESGIRLRQLGIELEKNGLMLPNLGSIDEQSIAGVISTGTHGSSLKYGLLSERVLGLSIMLANGQVVRCSEATNPSLFRAALVSLGAIGIITEMTLQAVPTFNIAWQQSLKTLPQVLDTWDSGLWTSTEYVRVWWMPYMKRAIVWRADKTDLPTRDPPASWYGGALGYFIYHNLLYLSNYVPRILPWVEWFVFGMQYGFTPGKTITEAVQPARTGLLMDCLYSQFVNEWALPLEKGPEAITRLSAWFHGDEETARIPFSSESVWVHCPIEVRVSDTSISKTPRPYLDSTYPDGPTLFLNATLYRPYLRDPPCRERYYEAFEWLMRDLGGKPHWAKNFGEDLGYEALREMYGDNLDQWLQARNEADPDGMFLGAWHRRHLLPPSTAASQSPGQTLAFEEQLKEQRVLGAPGAGDGIEWIGTIPGCTPHGNGDMEDGANAAGSHPSPPTTSASEESFDHLAKGEASITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ06</accession>
    <name>D4DJ06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_07171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018811.1">
        <property type="nucleotide sequence ID" value="XM_003018765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ06"/>
    <dbReference type="GeneID" id="9581371"/>
    <dbReference type="KEGG" id="tve:TRV_07171"/>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056536" description="Store-operated calcium entry-associated regulatory factor" evidence="15">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE38166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="31566" checksum="2A10A701BB200989" modified="2010-05-18" version="1">MFAAVTCLIALSALLQPVASYGNNKSPSRNAVLLSDVQTLTFHANRKTTHRRVSAIPQLNCVGPSKEICSLYKPDVIRCSNEGYDYDENDVQWTCTAQLPPEFKLGGTEVICEGYRNSNDPWILKGSCGVEHRLLLTSMGEKRYGHIPHDRDGYDESIWSTIIRMAVFFGLFMAVVKLLQYCTGIQGQGWGRNGAGGGGGGGGGGGGGWWPPGPPPPYDYQQPRFAKDDWQSWRPGFWTGALGGTAAGYAMGRGSRRGGDNTFRSGSNNAAPGPSFSSPTRESTGFGGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ27</accession>
    <name>D4DJ27_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable beta-glucosidase F</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cellobiase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Gentiobiase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_07192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018790.1">
        <property type="nucleotide sequence ID" value="XM_003018744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ27"/>
    <dbReference type="GeneID" id="9581187"/>
    <dbReference type="KEGG" id="tve:TRV_07192"/>
    <dbReference type="HOGENOM" id="CLU_004542_6_1_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="15">
        <location>
            <begin position="141"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE38145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="313" mass="33302" checksum="0D5C617536171225" modified="2010-05-18" version="1">MAVVCEITFHQSSKPNRGSGDRLQMECDQLAAALVAASMVDGGDPIAGETWRLVPPLLLFACLFTTASGSTLNVRADVPPGYNSPPYYPTPKGGWVQEWQAAYAKAAAVVANMTLAEKVNLTTGTGIFMGPCVGQTGSALRFGIPNLCLQDGPLGVRNTDHNTAFPAGITVGATFDKKLMYERGVAMGEEFRGKGVNFHLGPSVGPLGRKPRGGRNWEGFGADPSLQAIGGALTIKGVQKSGVIATVKHLVGNEQEIHRMTNVVQRGYSSNIDDRTLHELYLWPFAEAVRAGVGALMMAYNDVPQPLIFIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF3</accession>
    <name>D4DJF3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018631.1">
        <property type="nucleotide sequence ID" value="XM_003018585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF3"/>
    <dbReference type="GeneID" id="9580782"/>
    <dbReference type="KEGG" id="tve:TRV_07319"/>
    <dbReference type="HOGENOM" id="CLU_083054_0_0_1"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="1">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="232" mass="25879" checksum="604FA43AAFEC3C1F" modified="2010-05-18" version="1">MPPLDILLTEQPNLTYGQNIEPDIFPRRCFPDPCKHIKFNPEYADSVCGDPRLGPLTLPSRFPVSVETATYYRYGGLCADEFILRWAGDLDPKKWFNYPDFDGFALDSQGKPIKAEVTLTVGRKVDRFGSPKGKFVAPLGSSYISRSLPPSNLAPGKTGNYPDNYHVYMVLKPFSGFLGPVASWFGQPGLGSQIHLKSSVEELLTGGFLRELREDEYDEPSEYSYDPNPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ3</accession>
    <name>D4DJJ3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018601.1">
        <property type="nucleotide sequence ID" value="XM_003018555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ3"/>
    <dbReference type="GeneID" id="9580776"/>
    <dbReference type="KEGG" id="tve:TRV_07361"/>
    <dbReference type="HOGENOM" id="CLU_1932692_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="131" mass="14102" checksum="3412F033764657FC" modified="2010-05-18" version="1" fragment="single">MPNDADAGFTNGHSNERTGLLNGDSGRHGGGSQRWSRRDDRFWVWIPCEAGHLTYATLASNYINILLVFVPLGLLSGFLKWSATATFVLNFIAIMPLASLLSFATEELASTLGETLGGLLNATFGNAVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK44</accession>
    <name>D4DK44_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">TRV_07565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018411.1">
        <property type="nucleotide sequence ID" value="XM_003018365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK44"/>
    <dbReference type="GeneID" id="9584352"/>
    <dbReference type="KEGG" id="tve:TRV_07565"/>
    <dbReference type="HOGENOM" id="CLU_084856_2_1_1"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="20793" checksum="84112F31D49FAA0D" modified="2010-05-18" version="1">MATMARETPQPQPEQPRSSASTSASTASPSTQSAFSLPTSTKLLIGGSAFFVLSTFITRRSLNRRRLAAIPQFYTTASHHKPNVSAPLEALEALNLATLNVLALAILGVGAGMKAVGFETLDELRRIVRGGLGADGTGRTEQQVEEDMEEWVVSVLNRKASKENANAKEAEKQRAQDEIRKTWLNERGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK77</accession>
    <name>D4DK77_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018404.1">
        <property type="nucleotide sequence ID" value="XM_003018358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK77"/>
    <dbReference type="GeneID" id="9584322"/>
    <dbReference type="KEGG" id="tve:TRV_07598"/>
    <dbReference type="HOGENOM" id="CLU_570105_0_0_1"/>
    <dbReference type="OrthoDB" id="4173209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="477" mass="53673" checksum="D510D8E9B2A7610A" modified="2010-05-18" version="1">MREANNKSELLPPFLISSLVIVIILIALLWFKHLYKISASRGPLINTEEESPFNPQPQTPQQEPIPSSPGNTAGTSTTELRIQRLIRKNKPGSSLAPSSTSFSQDIGYRRQSCETMHKFPDSPVVSQDELQDFGASNSVPSGTSTLFPSSSGGRSGNDYRTQQSIPLRELTRDQTHKLNNPHPYYGHKGESYQQNNPYGRYACRQDEFYRNNSTPTGPFGTVGSDTVRETESSSRDFSYTGSTRQLREEHMRSSPERSKYTHPSYERRESRSPPRSGEGESFHSSLRPDPLCIHKARSSPLPSISSSDRYTSGMAQPESSKDASQRSARYDFKGRSSLEYRHPRQDWLSQAQVGSVRNDSKWRQKEAITRDEDGLRTFEGSRTFSIERSRSHPFGKQHNRDNTQISSTSATRHDNPGTAERPEEPYPISAGQTPVAYGLPPGSARPLAEFVNDTDENKVERKLNLLDLVSQLRDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK87</accession>
    <name>D4DK87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_07608</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018372.1">
        <property type="nucleotide sequence ID" value="XM_003018326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK87"/>
    <dbReference type="GeneID" id="9584305"/>
    <dbReference type="KEGG" id="tve:TRV_07608"/>
    <dbReference type="HOGENOM" id="CLU_008092_0_0_1"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="103"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="577"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="734"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="803"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="939" mass="99595" checksum="CD61F0C7F7CE194D" modified="2010-05-18" version="1">MSEVQSRPSASRGRGSARGGRGGHISRGGRGGARSTAAAKSAAASQETAADTSHEDEGEIGQLKKKYAGSLSTIKELFADWTDEDLVFALEDANGDLEVAIERITEGNVSQWGEVKKKSSDRTRQKASSKDAHPISGEQNIPPSRPGRGRGGFDQRGRGRGDRGRGGRGGRAGSHAPLQPSQANGTTSNLTPTDGWDSNSAVEPPAGVESSAVESKPQPEWNTVQETPKVAVEQSTQKSSLIPEGSKRGWASLFAKPAPEPVKEPPLTTAPSAPEKPAEAPVEPSVPEPAPAAATEPELLPNDQQQENAEQQQQQQPPIAPAQQQQPVPVPVPKPVEQPRPVIPQQPPAPPSVSVPAEPEAPAQPDTESPADIEKEPASQHKQQQQQQPQARTPATSYAYPKGPAAGTARGPNFQRRVMEQQEPVVMPGNHAVDRATVQFGSMGLNGSTTDVNIDEEREEPETRPQPPQHSPVAPRASLPPSTRPVAVPETTATVPRPAPGLPPAPVASADTPFNDFSRYGDAQKPYDIFNQQADQQAQQPQSQEPFSNQGIPSQPAAVTTAADYSAFYGADQSRNPYYYSAYGQPQDPAASQRVGAGFAASGAESQPQVPASQPPGRYAHAEAPNSGQNTPQPVVPGQVQSAQQPSHHMPQSQGAHAGFNYGYPYYTNPHYPNAYMNQMTQHQQHQYGRNRPMYDDARRYEEQQQQQQQQQQQHYLPHQSQYAYGTQYAPYGKGGMYSQQPQQHGFGYESSPANTAAFNQSAAPQRDTATYGRAGSAQPADGQQQQSTGANAFSGIPDVFGRTQSGFGQNQPIPSQQATSADETGSSKAYDSSKTGGPSPSVSQVNRPGSAANNAPHQPATTGQSGLPPVPAAQQANQQAFGGYPHLNQQYGGLGGLGAHQAGTTHQATAYNNYGAGFGSNYYGNNGRGGGWGGNYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKB1</accession>
    <name>D4DKB1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000459">
        <property type="protein sequence ID" value="EFE37717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018362.1">
        <property type="nucleotide sequence ID" value="XM_003018316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKB1"/>
    <dbReference type="GeneID" id="9584290"/>
    <dbReference type="KEGG" id="tve:TRV_07632"/>
    <dbReference type="HOGENOM" id="CLU_1237645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="224" mass="25024" checksum="D49338BC3B424A7E" modified="2010-05-18" version="1" fragment="single">MHPVFGYQAYAGSVLYARSGAVCKERCKLKAAQWQMPSRIKLYISTYSLESVQIHIPAFSPQASQNALPTLEAARAKFKSINGDELVNNVFRPFFVDGGMEKRLGLAILHRHFDLNVDERLVDYNGTSLPWPTAHTQEIEEPYASIWSKAADGTFRPTEYRYSQNPEAAAIGPAELNFMEEFDKLLQQHGASDLFGLCLYPGDDFEGSCEITVGRANINLKPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF5</accession>
    <name>D4DKF5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018298.1">
        <property type="nucleotide sequence ID" value="XM_003018252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF5"/>
    <dbReference type="GeneID" id="9580009"/>
    <dbReference type="KEGG" id="tve:TRV_07677"/>
    <dbReference type="HOGENOM" id="CLU_043293_0_1_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="201"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="431" mass="49308" checksum="35D17200F8583AE7" modified="2010-05-18" version="1">MLNASATELPPLPSYTLTPRQPLIAPIPDNATILILPVVAYWALSMIFHWIDVNDYFPQYRLHTPAEILKRNHVTRWEVVRDVILQQIIQTLFGILLIFFDQPEFNGREEYDIAVWATRIRLAQRAVPRLMMLLGVDPVSLAAKLSGYPILAAVVSGGHYPFLTQVVTSSTGETATAPAFAAWEWAVGYSIYYYLIPALQFVYAITFVDTWQYFLHRAMHMNKWLYTTFHSRHHRLYVPYAFGALYNHPFEGFLLDTAGTGLAFLTCGMTTRQGMWFFTCSTLKTVDDHCGYAFPWDPLQHVTGNNAAYHDIHHQSWGIKSNFSQPFFTFWDRLLDTRWKGDVTLRYERSRMAAQKKVDVDLASCSQTDGTQEQKQIPQSETHIVASRDDDDASTRSLLKRSVRKTTNSFSPQSDSLKGLTHRLSGSIQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK1</accession>
    <name>D4DKK1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline iminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018273.1">
        <property type="nucleotide sequence ID" value="XM_003018227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK1"/>
    <dbReference type="ESTHER" id="trivh-d4dkk1">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="GeneID" id="9579969"/>
    <dbReference type="KEGG" id="tve:TRV_07723"/>
    <dbReference type="HOGENOM" id="CLU_043739_2_0_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="41478" checksum="82A5ADA876C0EA74" modified="2010-05-18" version="1">MSSQALHPGYSHADAFDEGFLSVGSIHKIHYEQYGKKDGKPVIFLHGGPGGHCTKINTTFFDPEVYRVVLFDQRGSGKSLPNSELRENTTHHLVEDIEAIRKHMGVEKWHMVFGGSWGSTLALVYAQAHPEVVGSLVLRGIFTFRREELEWSRSIVAGRLYPDAYEEFVNYLPEPARADIVGSYYQLLLSDNRETRISASKAWNKWELSISELRQNPQSLKKLEDDDWTLAHASMELHYAMNDAWLEHGALLKKENIDRIRHIPSSSGFRMPDTVQCSYQYAQERIYIAIRLNLMTGLPFLSSGVPWLFSMLLFTAAAISSPNTNADHNGDTDAASANQRASGSPDAPNYSLHRQSSDRQSMSSSEPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK8</accession>
    <name>D4DKK8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018280.1">
        <property type="nucleotide sequence ID" value="XM_003018234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK8"/>
    <dbReference type="GeneID" id="9579976"/>
    <dbReference type="KEGG" id="tve:TRV_07730"/>
    <dbReference type="HOGENOM" id="CLU_008109_0_0_1"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="83733" checksum="CE43579D6ABA6D8D" modified="2010-05-18" version="1">MPRPKKPGAPEPKRRSRKGCCGEEKPSCINCKRQGDKCDYSIRLNWEGRARKRAAAEDTGLNRESIPSPSSPATPNSARDRASFSPASSVKHIFMPIQQYLGPHLDNKQQSDHGEVLSEPFGSPIIPVNDSQPLSGLSACLPRTSADLAWLPYTPNSSSYASPGQSTSPSHYQKITAGESSEVTSPSSSTLAQHVDPQRLSTTAHTNYIPTPNTGMFRASELAITESPASCMAEETLLQFPLGSNTSGANTPADMHRVSVNSLLSVPSGPDSNHGRSYGLDCGQPDLDVYRDAELLASLRDTPTSGINNLKAIQYQKVSSGTATPSSSQEDISAGLHRSVTTVFSKGGYYAKPVPILIPRLLSPLPPTLLESPINMLYFHHFINHTARILVPHDCHLNPFATVLPAMAIEDENILNLLLAYSASHRSRLLGHAEPYTRIARWTSGVFPSLRHALGDPRRRTSAATLATAIMLVSLKVISPSTFEVPIRWESHLMTAREIFLTRQKTDPEHFTGKVNTFLHRWLVYLDLFGSLSSRRAEAPLFNGTYWPLDTETEYPKNVIDQEFEVDCFTGFTPRCCSLLARLSALTHQCDNVRVDPAGRLFTSWNPPTSVLAKAERLLQDMEDAGPERRSVPMTHHGKLVDHGMAAMDEAYRLAGMIHLHRRVLGRETSDPIVKSLVDALFDSLDQVSRGGQEEVCILFPLFTAGCESQNEGQRRQVSERVQGFESVGMKQIRGARKLMQKSWRVGLPWNVLADGEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN8</accession>
    <name>D4DKN8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000477">
        <property type="protein sequence ID" value="EFE37582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018227.1">
        <property type="nucleotide sequence ID" value="XM_003018181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKN8"/>
    <dbReference type="GeneID" id="9579601"/>
    <dbReference type="KEGG" id="tve:TRV_07760"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34242" checksum="756C26EE5C639F64" modified="2010-05-18" version="1">MDAYADLWEKGYLLPNDEKEQDHMNIISHLFKLILGGRLFLAPLPPKMKRILDIGTGTGDWAIDMGESECVFYYGRVYAWLTLLADRYPDADIRMLCVPPNVQFEIDDVENDWAHHHPFDYIHCRFMASSIRDWPRLFRQILENLTPNGYAEFYDFDFFFRSDDNSLLPTHEMYINCAETTSAAEKIGQTACPGPHLAKWAREAGFVNVTERKMKVPVGPWAKDPKLKEIGAWNHVQAMEGMEGWSMALLTRVNGWSEQRVREHLVRLKRDYQDTKIHAYMTAYVVYGQRPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKT3</accession>
    <name>D4DKT3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000482">
        <property type="protein sequence ID" value="EFE37543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018188.1">
        <property type="nucleotide sequence ID" value="XM_003018142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKT3"/>
    <dbReference type="GeneID" id="9579559"/>
    <dbReference type="KEGG" id="tve:TRV_07807"/>
    <dbReference type="HOGENOM" id="CLU_026648_0_0_1"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="47927" checksum="31565623552E12AC" modified="2010-05-18" version="1">MADSPAVFAPVDPAEQPILERLITIRDGLVLIKQDKSTYVKSHDVIPFYDQAIEQVQILNQHRAGRRVAQNRVDNVLDDCFQLISLLFLTVGKNNEAPAVEAAFFSQKDLDSISGSLDGVESNIRRGKDTYSPHLLTLLETRLETCRSQLAELQHDLSLLSPELTPTHEILVSILRSTSAANTRSKFSASEVLGFKDQLNAIKSKMVDGNFVAANGSIPAGQRIVKDLLEKCFKWSDIVLERQGQVNEAFLDYYNQLIDIRNQLDRLSMTHAWSLRESDLYMYQRKLNKIDECRVDGNFLDASGKPADLHAQRTLLYLIRRSYALIYGLLVSSEPVSEALLPIYNQLQTLRKCLIEVKESGGVSSARELYPYSMKLNSIDNMRVDGKFYIGSDLPEGQGGVNELLAECYDLCYDLRADAEDIASPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLA0</accession>
    <name>D4DLA0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000497">
        <property type="protein sequence ID" value="EFE37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018022.1">
        <property type="nucleotide sequence ID" value="XM_003017976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLA0"/>
    <dbReference type="GeneID" id="9579149"/>
    <dbReference type="KEGG" id="tve:TRV_07974"/>
    <dbReference type="HOGENOM" id="CLU_3002307_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="57" mass="7020" checksum="A0D3E69D23A7D64B" modified="2010-05-18" version="1" fragment="single">RREKKMKKKKKKGRKQENKKDNKRKRPGVELGWHWSVKRRKRSSEDEDAAVYNTPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC2</accession>
    <name>D4DLC2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017992.1">
        <property type="nucleotide sequence ID" value="XM_003017946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC2"/>
    <dbReference type="GeneID" id="9579120"/>
    <dbReference type="KEGG" id="tve:TRV_07996"/>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="252"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="48800" checksum="3822EE0F9619F911" modified="2010-05-18" version="1">MSESPEPRLDSPALDKDENEEDVTLDKERDIAADISDDESVLSDVDEEQFKEFDPADIPLDDRPALAIDEENLKLVGRHKRRRTEEDGEGQTKKKKKEGRRDKKSHRKKQGSEEFSGGEEMDGKRRRKRREGGGEKAPRQSKKQVEEEIDEESLDPATRRRRALDRMMDEALKKPSKRRIKKADGIDLADYADAEIEEVRKRMTDAARLDSIARKENRPAMHKLKMLPEVVSLLNRNQYVNSLIDPEINLLEAVKFFLEPLDDGSLPAYNIQRDLMAALLRLPINKETLIASGIGKVIVFYTKSKRPEIGIKRQAERLLAEWTRPILQRSDDYSKRVYEEVDFDPSRLADRTVSAEASAAEARARELLPPRLANRARVESSHTSYTVVPRSMGVSESKFARPLGASGEDRFRRMKARQIAANKGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZG3</accession>
    <name>D4CZG3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025565.1">
        <property type="nucleotide sequence ID" value="XM_003025519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZG3"/>
    <dbReference type="GeneID" id="9581803"/>
    <dbReference type="KEGG" id="tve:TRV_00205"/>
    <dbReference type="HOGENOM" id="CLU_375955_0_0_1"/>
    <dbReference type="OrthoDB" id="4524386at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="650" mass="71627" checksum="66BE9B90A14F484C" modified="2010-05-18" version="1">MSSPRRTRRHVDVLEAIFSKQSLYHAPTVVPLTTTSYNEDIAERNLAGGGQEHGSCPSRYSHVISAIYQEDVADRNMVPFSPPILISPPPGEEQVAGNNQKRAVARRVKKSQRESDSSLCEETAALRTIASDQDIRRHPSCSSNRNELSSGKKLRADMDENNPLRSRKSAPNFSVHPAEDEEQNPNEASTASKKLPQARRTQDISQAEQGCEQTIERPLSKSSNDDPKTARESTSKSESQENSSSPAHSSSNRLLSPNSARRRVKRNVRDLSINTQLAAPGKKFAKISKKSPLRPVPVSPCREPSSTLDEIVNSPIALTSPINPSPRLTGFTASEMLNLFKQAYASSQTNATRPTFESLQDAIIREINSHDAFSHLNPQSPSPVSPVPSLTPDLSTNGKQTEKYTTRPMTALSATRSISSREGSVRSKRSFCCDHQSRPDSQGREVSFPAIKELDPENSNSVALKRRHSCSQPAPSPRVRIFEPNDCLHGRRQQVSVATGQVSDMYQTKDPIGHSSLHFRQQLSNGYISKAVSIFDTPQTMKPSMSINGRDGVHMGDISPPVVTIFSDVEEKPYSGLRRKRSTTMKSSKLHLFIPCRKSSRPKHIPIVISNTTTNNVLYDPPSSGTKKSPISPLSTSSGRKRMPFRIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D027</accession>
    <name>D4D027_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025360.1">
        <property type="nucleotide sequence ID" value="XM_003025314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D027"/>
    <dbReference type="GeneID" id="9581596"/>
    <dbReference type="KEGG" id="tve:TRV_00421"/>
    <dbReference type="HOGENOM" id="CLU_049332_1_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="448" mass="50118" checksum="63039B770CC8CDD6" modified="2010-05-18" version="1">MSHQATESFYDQFFLDYENNYHNNEGLKAFVREAASKLPAHAKVLDVGCGTGRPIAEALCAAELDVTGIDLSTEMVEMCKRRFPSAKFIKTDMTKFRPQQNFDAVFAVLSLFHVSHRECYSMLFKFADWLKEGGRLFITTIYSHDLVDRGAKPDSQGIIDLADCQFLSHDVPLTAFSSEKWEEYLTAAGFVGFHATKYDFQPADPKLKVAHHHFITVNRGDNHPLMGPYPYPDKVLGPYSLQKTAYKSFMERLNDVESNALAGLRQPFLSFFLFADPMNRSDSFPFSAQEVSNKFDSIVLSRVLDGLEDINAPLQKAMKATSKIVVIQAAPDNDLLKQANLSSNKAPMHHGLILHRAAEILKTNGFGSLELIHISDSACRFSEEDLSARSKVAAILIADMFYSYEADLQSIKDALVPRMEALFKETPHDVGNQSVMLVARPVTQARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0F1</accession>
    <name>D4D0F1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000030">
        <property type="protein sequence ID" value="EFE44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025286.1">
        <property type="nucleotide sequence ID" value="XM_003025240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0F1"/>
    <dbReference type="GeneID" id="9582895"/>
    <dbReference type="KEGG" id="tve:TRV_00546"/>
    <dbReference type="HOGENOM" id="CLU_056435_7_1_1"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20269" checksum="73264CCEA0F5DC7D" modified="2010-05-18" version="1">MSNLNPGLSERFLNLKDKRPIEVWEELWQEEKTPWDRGVHNPALEDTLEQKSDILGNAIIKIEGEEKRRKKALVPGCGRGVDCFLLASFGYDAYGLEYSTTALEECQKEAEKYGDLVKPRDEEIGSGKVVFLQGDFFKSDWVEKAGLEEGCFDLIYDYTVSCLRDYEDCFWTTTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0F2</accession>
    <name>D4D0F2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000030">
        <property type="protein sequence ID" value="EFE44676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025287.1">
        <property type="nucleotide sequence ID" value="XM_003025241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0F2"/>
    <dbReference type="GeneID" id="9582898"/>
    <dbReference type="KEGG" id="tve:TRV_00547"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="115"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="576" mass="62949" checksum="D691E94FAE3942C9" modified="2010-05-18" version="1">MGAEKQQSTGNSSQVGFPATSSTLTVSGEPSIATTQGVSDYAPVISEKGSQVSIDNGESNQPLDEEAAVQLTRTNSYIPPVVVPRGRRRGLFGSLTLLAEVENPKHYNRKSKWFITFVVAVAAAAAPMGSAIFLPGLGEVARTYNTTATVTNLSVALYMLSISIFPLWWSSFSERLGRRSIYLASFALFTLWSILSALSVSITMLIIMRVLAGGAAASVQAVGAGTIADVWDPIDRGRAMGIFYLGPLCGPLIAPILGGILTQSLGWRSTQWFLAIYGGLILVFILFALPETLAHRKPLPPPQPENGSPEIERTLSRVSSRQVVQQTTRALNMFKIIIIDPLKIILYIRFPAVALTVYYASIAFGCLYVMNISIEITFSRDPYNFSTIIIGLLYIPGALGYIVASVFGGPWMDSIMKREARRANRVDANGKYIFIPEDRMCENAWVGALLFPSALIWYAWTAENGVHWFATIAANFFFGLGSMLIFSMSTTMLTEFMPNRSSAGVALNNFMRNIASCVGGVVAAPIIDAIGNGWLFTILGLICLASSVVIWAMKRLGPRWRITMEEQLKKENENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0I4</accession>
    <name>D4D0I4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COP9 signalosome subunit 8 (CsnH), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025263.1">
        <property type="nucleotide sequence ID" value="XM_003025217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0I4"/>
    <dbReference type="GeneID" id="9580756"/>
    <dbReference type="KEGG" id="tve:TRV_00579"/>
    <dbReference type="HOGENOM" id="CLU_108986_0_0_1"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="1">
        <location>
            <begin position="48"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="24536" checksum="FDFD02A865E1D996" modified="2010-05-18" version="1">MSSAPSVPERLTEILSTSTSPLESLIELEGEINIKHLQDGTASDREFLSTYYSSYLICLLLDDDIHEARMIFRRLPLTLLEDDTLMKALEKLVRAVGTRDHGTVYEILKTAPWHKLTEPLVQSYTVHYRNKVIDDTSLSYKTVRLPTIESKLGLEPDSDAMQDTGDDVPSQLIQDLSAKGWTYDSVSRLMHPARPVTQPGAQERITLGQVTALIGNHGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D174</accession>
    <name>D4D174_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025017.1">
        <property type="nucleotide sequence ID" value="XM_003024971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D174"/>
    <dbReference type="GeneID" id="9580509"/>
    <dbReference type="KEGG" id="tve:TRV_00822"/>
    <dbReference type="HOGENOM" id="CLU_1476184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21170" checksum="915DD186F1657660" modified="2010-05-18" version="1">MPPTILQELDTIYPDKGPKITANLQGKILIIEAIITKAHEIAARRLEVYIDQEIMKMGLEFEILNSGEARTTSGTFVKEPDASFTLSDHDWPILVIEAGVSESDTKLKMDARGWLESAGSETKVTITIIINRHSPQIDFKKWEHSTSIQNRNCPRQIFQWHRRYYRRHDHTIRKDSRKETPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D1</accession>
    <name>D4D1D1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024960.1">
        <property type="nucleotide sequence ID" value="XM_003024914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D1"/>
    <dbReference type="GeneID" id="9580452"/>
    <dbReference type="KEGG" id="tve:TRV_00881"/>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="37503" checksum="16817D678AFD64B9" modified="2010-05-18" version="1">MGGKSEAKAAYFDKLKGLLDEYQSIFIVNVDNVSSQQMHEIRLALRGQGVVLMGKNTMEQVRRALKGFISENPEYERLLPFVKGNVGFIFTNGDLKEIREKIISNRVAAPARAGAIAPVDVYIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTELRLVEAKTKVGPSEATLLNMLNISPFTYGMTVAQIYDAGQTFDSSVLDIEEDHLLSVFQSAVNNIACVSLAANFPTMPSVIHSLINAYKKCVAIGIETEYSWESIEELKDRIANPDAYVSTGPAVTESKEDKPKEEAKVEEEEEESDEGGEYSIILLFFFSFLWVKGDMLTKLPQQTGFGDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1E4</accession>
    <name>D4D1E4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024973.1">
        <property type="nucleotide sequence ID" value="XM_003024927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1E4"/>
    <dbReference type="GeneID" id="9580465"/>
    <dbReference type="KEGG" id="tve:TRV_00894"/>
    <dbReference type="HOGENOM" id="CLU_005248_1_1_1"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1241" mass="135221" checksum="AFA69EE36DD9F82E" modified="2010-05-18" version="1">MRRTRRLSRPIASLWAQKSAQSESDDRNQSQSQSQSQSQSQSQSESQTAPSSPPYDAEPLVVPELEPVFAYLNNQANKLYQEGYFLKLNDLDTQGRACTDRQWVECFGQLVGTVLSIWNASALDTAGGQANASPSFINLADATIKMMETLPTNNETNQPLQNVVSISTAGKNRYLLHFDSLHSLTQWTAAMRLTVFENSLLHESYTGALIAGKGKYLNGIKLVLEKTTFKYEDWARVRFGAGTPWRRCWCVISPPGEKEMQLYNRSLKKKSAYDRAPTPPKGNIKFYETRKTSKKVAPIATISDAYSAYAIYPQARPLVDQSTLVKVEGLVTIGENTSEGFVFVLPEMHNAVSGFETMIRWLFPAYDAFRLYGRPNRLLADTVSPNSLMFAMPSNKRRGYLDILDVSALIHTQGSDSWSAREWRKQLKDATSRRMTSNAGSSRTSSVSGHRSGKRSSLPQRTGTVRFGSATVGPRNGEPNSSSDTVASNSPTKPGISHTRSESDNTGLPSARRGRRSPPFFENHIGEDIPEHPPTPPPELPQADGPSEIDGTDSRSSPDSGAYMDNNRPVDRLEIIQSLEPNPPPQGVPVSPAFSHDPRGTPQFKPQPSPEIGHAANRMSVGTLDQLVDMNKKNGNAHGLAVAGATAAWNAAKDNNNNNETDRGTGQRADPRGPTLNRLNSIGASSSNYSQGSPITPSDTTSNVNVGVDTNLTGTPTEGRSPIKQQDGTQNPPLHKPIARKPVATETPIAETASVRTASTLGSLRDNIDMDALDRIIRRPRSPSPPPPPQPKYTFKQEPAIQDDGSSIVAPSYASSHKSSASVRSIQSVQKPRMGKMKVVGDAMPKTDDLVIGDARYKHPAVTPVEVSSDIPEVDFGPTHTYKPTARRPSTSDTMLLLSSSHQRNPSEGTLATRGRRLSTGRLLEHLNQESNESPSPPPPTQERGRRRSVLWQPGMVQDSGPVTPGPTSISAEQFVHDRASRSQIHLPVMPTRATPPPPRPASGDWSAYIRHQSSATHLPQRPHSRGPSVMLDMPARPSSRGANTILDVPARPSSRGASVILGPLDAPARPSSRGANRMLAQPDISGHLSAREQEHVARVTGSSFLNLNNNQSPQFGSGLVSTIDARERERKAMKDGFSGQAVQQAIAQRQYQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQFQLQQQFQQPLGTPPGYAASMQFPYLPQQQPQQPPQAGYYAPPQGQQWQPQYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1P9</accession>
    <name>D4D1P9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_00992</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024827.1">
        <property type="nucleotide sequence ID" value="XM_003024781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1P9"/>
    <dbReference type="GeneID" id="9580336"/>
    <dbReference type="KEGG" id="tve:TRV_00992"/>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="21">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE44216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="915" mass="98612" checksum="0C7200BAC153A397" modified="2010-05-18" version="1">MSLRFDNQVVVVTGAGGGLGKAYALYFASKGAGVVVNDLGVSHSGEGQSSKAADVVVEEIKAAGGKAVANYDSVEFGDKIIDTAIKTFGRIDVLINNAGILRDVSFKNMKDQDWDLIDKVHLFGAYKLYGVANRAEQCARAAWPHFRKQKFGRVINTTSAAGLFGSFGQTNYSAAKLALVGLTETLAKEGLKYNIHSNAIAPIAASRMTETVMPPELLANLKPEFVVPIVAYLVHSSTTETGSIFEAGAGHVAKIRWERSKGALMRADDSFTPGALLKRWEDVNDFSKPTHPTGPADYVELIQESMKLPANPPAEQPDFTGKVALVTGAGAGLGRSYALMFAKYGASVVVNDLMDPEPVVQEIKKAGGKAVGSKASCEDGPAIIKTAIDNFGRIDIVINNAGNLRDKAFTNMDDKLWTSVVNVHLRGTYSVTKAAWPYFLKQKFGRVVNTTSTSGIYGNFGQANYASAKLGILGLSRTLALEGAKYNIRVNTIAPNAGTDMTRTIMPEELVQALSPNQVAPLVVLLCSELLPEPTTKGLYECGSGWTGKTRWQRSGGHGFPVDAELTIEDVAKTWSKIIDFDDGRADHPDDTLAGTESIMANINNKVGESKKEEAPSGGDQTILDNISKAKEMKAEGTPFDYADKDIILYSLSVGAKRTQLPLVYENHDEFQALPTYGVIPWFNTAVPWNLGDIVANFSPMMLLHGEQYLEIRKYPIPTEAKTTTYPKLIDVIDKGNAAIVVMGYTTKNAKTGEDLFYNEFTMFIRGSGGFGGANKSTASRPAAATAAYKPPQRKADAVVEEKTGEDQAALYRLNGDRNPLHLDPDFSKMGGFKTPILHGLCSLGISGKHIYEKYGAFKNLKVRFAGVVLPGQTLRTEMWKEGNVVVFQTTVVETGKPAIAGAGVELVSNPKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T5</accession>
    <name>D4D1T5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_01037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024798.1">
        <property type="nucleotide sequence ID" value="XM_003024752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T5"/>
    <dbReference type="GeneID" id="9580288"/>
    <dbReference type="KEGG" id="tve:TRV_01037"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE44187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="371" mass="42307" checksum="7BD87B15F64B016F" modified="2010-05-18" version="1">MSTKALEARFERLDVNDENEPPASHHIKAKGVPSKCGPAPAHGNPTSNRPNLLKLALQNNNESKSHRSPLEEESSNTLRMNDSAGNPKKFHLGMFEIGKPLGKGKFGRVYLARERSTGFVCALKVLHKSELVHGHVEKQLRREIEIQSNLRHPNILRLYGHFHDSKRVFLILEFAGKGELYKHLRKENRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGNGDKWYDEKVDLWSLGVLIYEFLVGEAPFEDSPVMTHRRIVRGEMTIPSFVSPEARDLIKKLLVLDPASRIPLDEVQRHPWILKYCVKGERVAQREAAASKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1U6</accession>
    <name>D4D1U6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024766.1">
        <property type="nucleotide sequence ID" value="XM_003024720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1U6"/>
    <dbReference type="GeneID" id="9580256"/>
    <dbReference type="KEGG" id="tve:TRV_01048"/>
    <dbReference type="HOGENOM" id="CLU_424005_0_0_1"/>
    <dbReference type="OrthoDB" id="4173357at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="700" mass="79187" checksum="ACB715D7E2ABEA1B" modified="2010-05-18" version="1">MAFLSFHSRQLSLPLNVEIWLDTAGYIERQAGCFVSARLLFLLLLLLLYTSVMPNVHPASPDTRYTQPTLPILYNGNPLDSLVYTYCEPICNGCGKKLPSGKVGFVRRPIKIKPTKSILADAFLPNRDGSAWSFPYSYNLDAPLPIETGPKETHQPIALTDGPAQTYNHGREYQNKLATGRYDPVPSNLYHRDAALPPPAPSPILEPQSPTYSRAHAAPATETRHRCAVCGRYRSPSYQHRHPIIPGQIPPTSVCRKCRFTYTSSGDSTESDESDRRSRGRRRSRKRRSRSRPIFDKEPSAQPAPIPQILQAPAPQTSQPQEPPTPAPPPPPPPPPPQPQPQPLATKVESSPPIFHFCPNPPGLFLTAVLSRATTRSPTIETHAALVTIRCTAGVITIKTATMAIAATENPGSIPPESPGASMTFREPSPLRQAERPVVKDANSWSMPATGNWDDSNERVRKPRPPTPSPSPVRERRYVEPHQLSSSLRGTRPPQAKICRFASDEPQNQPNVQYQTWEVDRPKRQYSRVISRGDDNNNEESGWYDTPDYERPISTRPSRNVSMPRRPSRVETDRPPSEILIVPKPRRQFEVRYGTYQPEQQRDYEYREPRSETRFKHYEPSNPRRVTTVNRRSYAYPVVRDEQEEEDTGQGYSDPRYEKWNKSRYASHEIIEGPRGTYNPPATRDPSGQQYKARERSVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B9</accession>
    <name>D4D2B9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE43995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024606.1">
        <property type="nucleotide sequence ID" value="XM_003024560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B9"/>
    <dbReference type="GeneID" id="9579930"/>
    <dbReference type="KEGG" id="tve:TRV_01222"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arf-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="491" mass="51325" checksum="DCE103E1C3B0539B" modified="2010-05-18" version="1">MGTHISRVKSVDLDSWTDEQLQSIMKWGNARANKKIENFIRTKYESKRWVMDGPMPDPSTLEVEGDEDVPLAVIQEKAKLERSASQQQHSSNRPRPTQPQQPAVNFFDDEPANPPPRPRTTDIPGNRPPPQAAVAPKTHKPADSLLGLDFFGPSQPSGGSNRPASTPGGNTPTSGPSRPDLKQSILSLYASAPPKPQEQPQHERNSSFSSFSLPPQQASKPDAFGGLSDAFSGLSFPSTTSPPVQRQQSTFSAFDSLTSSKSSPAAPKITSPAMSSGGSFFNDISAQPDPKPRQVASPPPSTFDLMGSTVGSTKAPAAPPSASNDMFGLFSSPVPQTTTAPTATDTINTSPPVASPSQTSVFNLSLPPQQPTVKSPPTSTVSPSNAFTASTLDPWGGNAWSMAEPSPPAAASKATSAMKVPDTLTANDIGSGWGAPSPATAKPAPAVAADEDFGGWADPTPAPIRNGNSSFSKGKSSGFGGGDDLFANVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H7</accession>
    <name>D4D2H7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01282</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024570.1">
        <property type="nucleotide sequence ID" value="XM_003024524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H7"/>
    <dbReference type="GeneID" id="9579894"/>
    <dbReference type="KEGG" id="tve:TRV_01282"/>
    <dbReference type="HOGENOM" id="CLU_018310_0_0_1"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="146"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="407" mass="43581" checksum="CF9C0D4676F3CCA0" modified="2010-05-18" version="1">MSQSHFVSNPFSANGGGSSVNRIDEEEENVTSPTDPVRPDAGSREVPRSTYTTNAHTNTNTNTNTSSSGSSASNMFGASPFGSAAGQHQEASSGFPNNYSLGRRTSVSAESLNPTTSGTDSWTPPHHPKSPAQLSRLQAAVSSNFLFAHLDDDQFKTVLDALVEKPVPAKDIKVITQGDAGDFFYIVESGHFDIHIHPSGTAQPGGLAGLGAKVTSIGPGGAFGELALMYNAPRAATVISTEPSTLWALDRITFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERSKIADALDTVKHPSGATIIAEGEPGESFYLLESGEAVAYKAGIEGPVKEYKRGDYFGELALLDDKPRQATVVSKSEVKVAKLGRDGFKRLLGPVEEIMRREDYGTASATDSEAGKEQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Q9</accession>
    <name>D4D2Q9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000075">
        <property type="protein sequence ID" value="EFE43860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024471.1">
        <property type="nucleotide sequence ID" value="XM_003024425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Q9"/>
    <dbReference type="GeneID" id="9579697"/>
    <dbReference type="KEGG" id="tve:TRV_01365"/>
    <dbReference type="HOGENOM" id="CLU_033444_1_0_1"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1308" evidence="3">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="606" mass="67587" checksum="E1A6F280BAB6C5EF" modified="2010-05-18" version="1" fragment="single">FFSLPLPLYIYIHIFGVIVVIVSMDNTLTALKPPPKNRTQTSQELASSLLEECNKLLSEISAFQSYLVTLGKPNLVELRQFKSIVQSELKSLQRLAARADEAAAEDAEDAPGTPQYTANIRAPEQNRGHEKDVEDSDEEYLGQAELKVVHSLRSSNFPFYANVWRTAKTTCTGLISLNKKFYFYKPVKGQCMQGDYKDLEVDIDDLKIKSNSKPGVEETVPKMRKRGVLIDIVADNGQEWVKVSTVTPNRLLCDLAKQGWEIGLNSDSEDNEGSNTASTSGKNDYDSEDEDDMIELLKLAVDMKKAAAEVRVRYKHPRVRLVLPKIVEGQIAEIDKVIRKVRMVGVTVECATAETSGLDFMVNKSGPVNNTDDAGSMFSSLLPSPFPPMTSTLNVDCTLLLAFVSDLSHARDLRCMPSYHPAINRQIELEAEKPLLLSELWPAAGDRNLVCTTRAAKRMREIVDTIGTPREKERTRLLMGEADDASDREALVSQFQKLSDYTIPLEWKLPIKVVDAQDDIDRGWKDDSLPSIACKIAQKLSDINRSVFLYGWAAGLTTISSNRTVVKQIETWVEEERGDDDEVCGPTVWVCDTARSLIGKDSSRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2T4</accession>
    <name>D4D2T4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase Rho4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024427.1">
        <property type="nucleotide sequence ID" value="XM_003024381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2T4"/>
    <dbReference type="GeneID" id="9579649"/>
    <dbReference type="KEGG" id="tve:TRV_01390"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30915" checksum="7532FBCF4779E19E" modified="2010-05-18" version="1">MSVHTFEERYGHSHIRRHSSVLSEKTPPLSPRRKPLRSQSTRVSNGTINTDLSVSSGQASQLSQGTSVTVPPSYSKKFVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYISHTIHKPSGKGVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPVSLENVMDKWYPEVLHFCPTTPLILVGLKSDLRSNRTCIDFLKAQGLTPVTPQQGQTVAERMGATYVECSSKQMIGVDEVFELAVNTVIDIEESAWTSKDSSRGKGGKKVKKRSCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Y7</accession>
    <name>D4D2Y7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin kinase</fullName>
            <ecNumber evidence="6">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_01443</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024377.1">
        <property type="nucleotide sequence ID" value="XM_003024331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Y7"/>
    <dbReference type="GeneID" id="9579516"/>
    <dbReference type="KEGG" id="tve:TRV_01443"/>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000008">
        <property type="entry name" value="Riboflavin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE43766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="227" mass="25451" checksum="A6802FE74B8D15FF" modified="2010-05-18" version="1">MRPDGPRDDFAGPDTGPESPFPIRMSGPVIKGFGRGSKEVRRRPAHLCFCPLGIPTANIPAETLSEYPDLQLGVYYGVAALDPAQFKYTRTESDAADEPVHTGTDIFPCVLSIGYNPFYKNTVRSVEIHILPHLSMESSPIAADTSGQRPLFHHFPDFYGTALNLLILGYIRPEYDYVSREALIDDIRIDCDVARRSLKRKAYAVFLNDVDASDEKANEARQWLRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D361</accession>
    <name>D4D361_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conidial pigment biosynthesis 1,3,6,8-tetrahydroxynaphthalene reductase Arp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024320.1">
        <property type="nucleotide sequence ID" value="XM_003024274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D361"/>
    <dbReference type="GeneID" id="9579428"/>
    <dbReference type="KEGG" id="tve:TRV_01518"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="29081" checksum="E788A36FD9AB0E00" modified="2010-05-18" version="1">MAAEAQVKLKDFGNIFSLEGKVAVVTGGSRGLGLHAASGLLQAGCSKVYITSRKAKACDEAVAALNALPNKRPGARAYSVPADSSKMSEIERLVAEVSKTTDHVDILFANAGATWGEKFDTHPEHAFQKVMDLNVKSVFYTVQKFAPLLEKSASIESTSRVIITASVAGIGVGTMGDNATFSYSTSKAAAIHLAKNLAVALGPRHILTNAIAPGFYPSKMANGLIEMQGGAKAMAAQTPNGKLGEPEDIAALVVFLAGRGASHINGAVITTDGGSVLKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D366</accession>
    <name>D4D366_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024325.1">
        <property type="nucleotide sequence ID" value="XM_003024279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D366"/>
    <dbReference type="GeneID" id="9579433"/>
    <dbReference type="KEGG" id="tve:TRV_01523"/>
    <dbReference type="HOGENOM" id="CLU_076340_0_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049511">
        <property type="entry name" value="PGH-like_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17660">
        <property type="entry name" value="BTRD1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055273" evidence="1">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="282" mass="32522" checksum="292F70138870EDBB" modified="2010-05-18" version="1">MKISAIALLASVATLLLPAVEGYGEWASFHGLDEQTFHNKFDGYIKLEWVPTYLSGFTNSHGNVSYNIVVENPKKYPSWHTYYEQTTYDYMNVAKEKKQLGFRLVQVDGHTGVSVNSFFTTWNHNRNDIPWADHINQSGDEFTRALKDYTKNGYRLKSLSGYGFSERQQQFASVWEKVPGPPQRVYIGLTAAEYKIKFNQARKDGYYPVKISPYNADTQVRFAGIFEHMDGNAVKPECQWGLTSDEYVKVFNNWRKKGYKPTVVNGYRDNGDKYAAIFNKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3L4</accession>
    <name>D4D3L4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024175.1">
        <property type="nucleotide sequence ID" value="XM_003024129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3L4"/>
    <dbReference type="GeneID" id="9579213"/>
    <dbReference type="KEGG" id="tve:TRV_01674"/>
    <dbReference type="HOGENOM" id="CLU_004962_3_1_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="63989" checksum="8AF71E918417F442" modified="2010-05-18" version="1">MGQQQSKNVSRSNGGGLQVEGLQAYPSISKSDTKDSSRSIRGSIRSKIPGSGRSDRTDSPRASNGTLARSDSAPPEGLDAAFARSSISRHARNLSGSSMPIPPISSQDDLQDEAPNPPPSPPHSSSIGRGHKDVKAAQKSGEVDHVSDAGPQHVAPTTVAQKAGESILIKRENSLNPVLNESGARSVIDQNGTNGSPGMTIGALKSIDVDDMITRLLDAGYSTKVTKAVCLKNAEIIAVCTAARELLLTQPALLELSAPVKIVGDVHGQYTDLIRLFEMCGFPPNSNYLFLGDYVDRGKQSLETILLLLCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNCLPIAAIVAGKIFCVHGGLSPSLSHMDDIRGIARPTDVPDYGLLNDLLWSDPAEMEEDWEPNERGVSYCFGKKVIMEFLQRHDFDLVCRAHMVVEDGYEFFNDRILVTVFSAPNYCGAFDNWGAIMSVSDELLCSFELLKPLDSSALKNHIKKGRNKRNNVLNSPVSSHPSSPSTVNPFLKTANRIYDINTNSLPSSLLWFLRRVIESDLRYPTYFSHPLEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Q8</accession>
    <name>D4D3Q8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024120.1">
        <property type="nucleotide sequence ID" value="XM_003024074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Q8"/>
    <dbReference type="GeneID" id="9577116"/>
    <dbReference type="KEGG" id="tve:TRV_01719"/>
    <dbReference type="HOGENOM" id="CLU_041458_0_1_1"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="389" mass="43705" checksum="F00B504C82F60E86" modified="2010-05-18" version="1">MNGTLVDPAQCFSHLVEHIPIWLTRVTELASHTAAKHAEFAAEYTRLSKLKPRQRRRRNSSLNTNKGEEDQRSVNSRNRPSSGSTYRHFDAQDPFRDPLIFKRLTRQNNQDAINRKRKQQDSASSAPSDADSCLARRVRQQVVIHYDSQTQTVLERLVRDIGGARNQIRKGRMNYMMKVDFSRRALPSHLFPAGGPDDDENTLTLPPHRSFRRSRSTHFDPKPGTNGTDTKSTTPAKQTASAFDTTDKQLEVAQSLCETAAHQFLRNGDCSRELSKTVERLNAALEMAQAEGTRLKAEKEAEKLRQQAEEEEQESKSDRTVVETVGPAGSDAHMQADTLQPVKMKMDMNVNGDAKAPPEMMGAIEVDDGSSTSSISIDLAAFRRRRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3V0</accession>
    <name>D4D3V0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024093.1">
        <property type="nucleotide sequence ID" value="XM_003024047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3V0"/>
    <dbReference type="GeneID" id="9577081"/>
    <dbReference type="KEGG" id="tve:TRV_01762"/>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="901" mass="100950" checksum="EAB84A7AE4E93B30" modified="2010-05-18" version="1">MLASGGHLHGQVTFTSVSAPSARNDSQLPTKEVAEYEKILNIRDQIFAGTHPRLKVPESVIRKVPPRTVGQTSPSSTSASVVAPSSQASASEPGPPSSLPPAHHAAQGTVTSSSWPQLASTAVGGDTDSPVTGASTPKPTSEIDPIFLTKSDDLIRAETQLQRQRIERALRDYAEQKRVEERQKPPLQELKPDFDVSDVLNKALEIVKPLSPPYDQDDNTGIDGDGDRANNGNAASDSFDENSYYSSRAPDSPQNEEYDEEMAPAPPLAQNMDTDESDETVIVDRAGVHEPEHVSASGNHHLLDQHANIDDDARRDLENIHPWTEDNENHYSPPEPYEEPEYSPPGPDLMVNGRQDLLEPSYLSPSSRRQPLQMQQPPDQPSPAPKNLRVVRNHITSPAAPQPSRVSPLAVTRVSSITQPRQGRQSRQSVKAPVDQGSARTSPETGHSQQLMSRKRRRIQQAQDKKKLAEERRAAASPDMPYIKPEPVSPPPFIDAPPAVSHYPRSRLVQEVPTDVDYVSRHDDHVIAGRAPAYDDGHGRNYELDSPIELHTPRTTSRIGYRRPIRDEHDLRRVASLQHARQAEYVQEYSEPIAEISPRHGRAVSYAEPIHSERPRYHEESQPAQYTTTRRYMTRPLSPQYRESYAPVRVSESRVMGPPPSQRRIVVDAEGNRFYESIDAPRAMPPVSVRPPRVEAYDGVSHAPTRSMSIVDDHYRDRRYIQEMPPPEITYRRNAGPGAGPGSSYTTGNELGDPRYYDSEAADRGPVMRSASVQVIDYPSRQPQHLRQPQPSFVDESHFPHEEIVRVASVRPPPVGVPRYEEHHEVRPRMTSVRPMRREMSVYVEDEAGHAREYPPVERYSGGPSYTARPMREERFYESAGPGRIEHDEGSEVIRRVSRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D424</accession>
    <name>D4D424_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein N-terminal asparagine amidohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024070.1">
        <property type="nucleotide sequence ID" value="XM_003024024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D424"/>
    <dbReference type="GeneID" id="9582763"/>
    <dbReference type="KEGG" id="tve:TRV_01837"/>
    <dbReference type="HOGENOM" id="CLU_009854_1_1_1"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="328" mass="36228" checksum="D9E18F5BFF95BB81" modified="2010-05-18" version="1">MRIATFQLRSRLADVEGNIRKADALVGKLDRMLQGNGKRKNLDLLVLPEMAFSAVGYPEICPSTLQDNLSLPAKTGEDVQDERRFNSLIVVKESGETLVNYRKHHLYYTDDPWAHEGESHESGFFLMPLSTPTKQQSIPKDDSGDASVSSSPKNEIPTTVGICMDINPYKFIASYSACEFATHARTSGAKLVVLSMAWLTLLSSEELSTMADKPDMDTFQYWISRFAPLFLPDEGGVEDSSDEMAEPQVIIVFANRAGEEEGQEGKDTARYAGSSCVVGIRRCPRKVGDEEDGNRVEILIWDMLGATEEGICLVDTDSTPRMVGSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D434</accession>
    <name>D4D434_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023986.1">
        <property type="nucleotide sequence ID" value="XM_003023940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D434"/>
    <dbReference type="GeneID" id="9582700"/>
    <dbReference type="KEGG" id="tve:TRV_01848"/>
    <dbReference type="HOGENOM" id="CLU_047893_1_1_1"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="339" mass="37650" checksum="4B15797F47EFF0C6" modified="2010-05-18" version="1">MKAFQRAIPTLRPLQLGRGLQVQQGPHRHARLVHSSTTKAAVAHPVNVSGPPPKPPGSTASPLRKRFWKDVHVKEAAGGHQIYLDSRPVRTPEKKILTVPSSKPHLAHAIALEWDLLKTAQHATKYHLIPMTSITGRAEDIAAEDAKGVTTIRDEITRVMLRYLETDTLLSWAPEKEPDYVGRSEEKRETLREKQIKAAQPIISTLVSTVWPGVELKPTLDANSIMPLPQPRQTIDVIRGWLSSLSPYDLAGVERAGIATKSLLVGARVVIEWSENFRHLRPSGASRTFGIEEAAHASSLEVRWQTENWGEVEDTHDVEREDLRRQLGSVILLVSGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D453</accession>
    <name>D4D453_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024005.1">
        <property type="nucleotide sequence ID" value="XM_003023959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D453"/>
    <dbReference type="GeneID" id="9582698"/>
    <dbReference type="KEGG" id="tve:TRV_01867"/>
    <dbReference type="HOGENOM" id="CLU_074847_0_0_1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="195" mass="21801" checksum="86D5D9CFE9C467E5" modified="2010-05-18" version="1">MYKDLIDSLLSKAKVQRAKKLDGALRYLSEYTPDAIFATDAALLKTKYATVLEKIISYVRSGGTIVFGATFSSFAKPDHLNRFFEFSWGLPWKSGSYHRTTVHVNTNCQGLSMERLQTSYSQKALYLKNVPPESRLYAADEESTIESHVFYPEPIHDLTQAAIVFAPYESGRIGYIGDVNGEDGSHAVILAMCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5C5</accession>
    <name>D4D5C5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_02295</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023548.1">
        <property type="nucleotide sequence ID" value="XM_003023502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577020"/>
    <dbReference type="KEGG" id="tve:TRV_02295"/>
    <dbReference type="HOGENOM" id="CLU_000430_4_0_1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="496"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1280"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1617"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="978"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1987"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2028" mass="224218" checksum="274A8616C8D637A1" modified="2010-05-18" version="1">MALGRVGHDGPSATSSPMLPSDGNHQQQQPQQQKRTFYHDSPELPPSTSFDPFSRSNNLRPDEDEDDGDSLRRPSVASATTVGSQGSRSHGGRFHKRLQGIFGDEFEQQDLSFPTTLRSSSRLSSSRPRTGSAGRARKGSTNSLSLDRTASPDPARPRTPIPSSEVTPWEYQNFRDIPNLGEAPVRQAPTTDPSENQPPAPAPKVRPTHRLHLTGHRHTQSKEDPPPNTANISTPLPPRPASGRDEIPPLMRQSREHSLQAPTPMSSSTTLGGRSASPTPSTRSLNPRDARDQSSNPSAPKRSLFDRIRRPKATSNSLKNLPSPSKSVQDMAKAASYFTSEPGSILRGRKGSSESTSRENNDLDRKKEGTTSKALSAIGPSRLRHGRRLLDGKGARDRRNKADSNQVFLDTNLGDMSGIVTQPDAISPTDTSVGIFGGAKPFPANGETIAPLDLIGTDDWHPPDSWQVKRPTEDTGTRLSSVADPGPEKEVDEDGHPFCIRVFRIDSTFATLSAGLNTTVTQLLEMLGRKSFLQEDLNNYEIVMRKNDLSRTLEPNERPILMQKRLLQQVGYHMSDRITEIGREDNSYICRFTFLPTKLGVYSNLDPELGFTDNQKYSHVDLEGRSVATIPLKLYKKASEIISLNLSKNLALDVPKDFIQSCINLREIRFTSNEAWQLPPSLSLASRLTYLDISNNRLEKLEHANLHKLKGLVSLKMANNKLSSLPANFWDFPSLRSLNLSSNNFRALPDFLGNLTSLVDLDISFNQIEDLPTIGQFTSLERLWVTNNSLSGPLVETFKGLTKLKEVDARFNNITSIDNMASLPRLETLLVGHNAVSAFSGSFPRLRTLVLDHCPVTEFDITSPLPTLHSLNIASAKLVEFRDSLFANVPNLTKLILNTNHFVTLSPNIGSLKKLEHLNLAKNPLSILPASIGCLTELKSLNLRECNLNRLPAEIWYCLKLESLNVSSNVLEIFPKPASSPPLPPSEATNNLTPMGTPLLRADSYDDVGGRSEEYDFRRPSHASTGRLQIGTPPDSTRKGSIPSMSSPGGRKSSNASRVTAESRKDSTFSQRIASTFASSLRQLYLADNRLEDDIFHQIALLTELRVLNLSYNGLTDLPPGFIRRLQYLSELYLSGNELSSLPSDDLEESSHLKVLHLNGNKFQVLPAELCKINKLAVLDVGSNSLKYNISNWPYDWNWNWNHNLRYLNFSGNKRFGINPSSAYTPSTDGTPSTDLTDFSSLSYIRVLGLMDVTITIPTIPEETEDRRVRTSSSLSGCIAYGLADSLGKNEHLSMIDMVVPRFRGSDMETIIGLFDGQPSMGGGSKIAKFLHENFTATFMEELGKLRKQNGETPEDALRRTFLALNKDMATAAYKPVDDKESRHWDRNPTAAKLLNREDAFSGGTATVLYLQNMELFVANVGDAQALLVQGNGQFKYLTKNHDPAEASERERIREAGGYVSRNGKLNDQLSVSRAFGHFHLVPAVIAAPSTVKVTLTSQDEMIILASGQLWDYVTPNVVVDVARSERTDLMIASQKIRDLAISYGATSKLMVMIAGVNDLKRRERSKFRSTSLSRPSPLNDEHMFPLTKRAKRARDIPSDSTLARLGHVEAPTGELAIVFTDIKQSTSLWETYPLAMRSAIQIHNELFRRQLRLIGGFEVKTEGDAFMVSFSTATAALLWCFTCQMQLLEAPWPTEVLQTPSCRETYDDDGNLIYRGLSVRMGMHWGRPLCEKDPVTGRMDYFGPMVNRASRISAVADGGQIFVSADFVTEMERTLEAFADYERTNSDSSEDTFGDEALGQATRRELYQLSTQGFEVKDLGERKLKGLENPESVYLLYPHALSGRLSVQPDMVASGEASSPGTLGKNSTLNIDADMFWQLLRIALRLEAFCSTLENPGGSMLLEPDLQIINAIKARGDEIDDAAVMKLLEHQVARIETCTNTLTIRTMMQPFKPNDTLLDHAVPMSDILQQLQSQLAEFKALKTQMNLTGAPTTPPPSGYSVEVPESTISSAQSSAINLAAPPHLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z2</accession>
    <name>D4D5Z2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023413.1">
        <property type="nucleotide sequence ID" value="XM_003023367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z2"/>
    <dbReference type="GeneID" id="9583433"/>
    <dbReference type="KEGG" id="tve:TRV_02515"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="248"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="412" mass="46115" checksum="00D042CE53245229" modified="2010-05-18" version="1">MKTMFVSYRLNICELYFVILQQPTHKVKDRSPTIHPSRDIACIVSQFILNSDKMTKGSFSGVPTVDISPYLADPKSDASRKVIEDVREACISTGFFQITGHGISKSLQQNIFDAAHSFFALPLEEKKKLNAANFIGHRGYDVLASQSYEEGVLPDLKEGYYVGSNVLPSDPLYGRFFMGQNVWPSTELLSTIRFQEPCERYHESVQHLAFKVLQLVGDTMIPHGHSTVGMTESMPTVLHNLIRLDKIPACPLRLLHYPSATRNGGSVTGKPQYGASAHTDFGVITLLLQDDNPGLEVLVEKDGKQVWWPIDPNPSAYVVNIGDMISMVTNGIYKSSMHRVVCKRPERERYSIVFFLDGCLNANLEPVEGFGHPEEGVGFSHKTVEQHMTERLSMSYAKEGKDPRHNEDTFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D601</accession>
    <name>D4D601_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023422.1">
        <property type="nucleotide sequence ID" value="XM_003023376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D601"/>
    <dbReference type="GeneID" id="9583442"/>
    <dbReference type="KEGG" id="tve:TRV_02524"/>
    <dbReference type="HOGENOM" id="CLU_2442467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="90" mass="10461" checksum="69B04234E01ECA19" modified="2010-05-18" version="1">MEVTRNNFSRLLPRMLQDIGDCSFVALDFEFSGIFNQKLRPASAYVDGDLSLQKRYEEVKQAAEEYQILQVGLTLVVEDSQNGWRYPFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D609</accession>
    <name>D4D609_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">37S ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000130">
        <property type="protein sequence ID" value="EFE42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023336.1">
        <property type="nucleotide sequence ID" value="XM_003023290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D609"/>
    <dbReference type="GeneID" id="9583355"/>
    <dbReference type="KEGG" id="tve:TRV_02532"/>
    <dbReference type="HOGENOM" id="CLU_1490050_0_0_1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="181" mass="20448" checksum="E3BFBFD8AFBA67B8" modified="2010-05-18" version="1">MQCGGVVDIVDRFYEKNTSKNFQFTRNRRKRSRQMTMALSPSLLTMRFFRHIIQRQFPSTTPKPHCTLSALSSQCLLRSSALNAFHKSFSTTSQLQATLNQVRRGCRSGQKARKKRSPALVNRPQLKGVCLKTQVEKPKKPNSGERKTARVKLTSGKVITAYIPGEGRTFGAKLVCDELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D651</accession>
    <name>D4D651_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein Rad7, protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023300.1">
        <property type="nucleotide sequence ID" value="XM_003023254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D651"/>
    <dbReference type="GeneID" id="9583320"/>
    <dbReference type="KEGG" id="tve:TRV_02574"/>
    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="57442" checksum="07F4F9535FC801A9" modified="2010-05-18" version="1" fragment="single">DVSDDDDEDYEEAFNQARVPAPGQLANCELCDKRFTVTAYSKTGPDGGLLCTPCGKQMAADEKKAKPKPKRQKARATRQMNSNLLDGIAQRGAFSLLEMCIRQVANNINDVEEFGDLPGELRLRLSQILSKRRVLTPRTLGLFLRSDVNTIDIFDAAKLEEEDFHRVFATMPFLERVNLCCAGQLKDGVLEYVMSRESHIKHLILDATNLVTEDCWRRFFQTCGSKLETVKLSYLDCAFNDETVEVMVSSCPNLRRLKLTDCWKLTYDCLKSIAKLDKLEYLSLDMRHRHEDSSHPDDNEANERDLESLNALLKARCSGLRTLSLKHFKPMRNSSLAIIHETARHLSKLRLSHNENFTDAALASLFRDWPNPPLTFIDFSSNRSLEPISLMPGTGNGDNSDDEDDTPGLGSEGFRAMMLHSGEKLEHLTISSCRQVGFDALEEVFGEGQTYPHLREIDLSFHTRIDDVVMRRLFKACPALRKVVAFACFNIVAVQPPAGVALIGGLNAHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D656</accession>
    <name>D4D656_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023245.1">
        <property type="nucleotide sequence ID" value="XM_003023199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D656"/>
    <dbReference type="GeneID" id="9583265"/>
    <dbReference type="KEGG" id="tve:TRV_02579"/>
    <dbReference type="HOGENOM" id="CLU_013985_6_2_1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF23">
        <property type="entry name" value="UPF0039 PROTEIN C11D3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="29681" checksum="12FA830546B811A4" modified="2010-05-18" version="1">MPKYKDDEVPLTCTNNLIAMSVSQSTIKVSLLSIDKSKRASKMEILQVPKGPVAPSDLVALCSRYRTARLRALKTYPEAFSSKYERESAFTDEQWAQRLQNPMSRTFVAVCVDHVTEAPSNVEDVEKLKSNEWVGMVVLLGPKVVGPSMKYAWDPFLSMAWMQPDDERDFNDAEAATFAVSMFVLPEAARRGVGKMLVSRMMDSAKEDGKRKSIGKLHVSLIVERDNDAAIRLYERCGFAHVDAGPDLDGVGDRPVPPLGMVCSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D690</accession>
    <name>D4D690_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023279.1">
        <property type="nucleotide sequence ID" value="XM_003023233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D690"/>
    <dbReference type="GeneID" id="9583299"/>
    <dbReference type="KEGG" id="tve:TRV_02613"/>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="239" mass="27293" checksum="1910C4C94FB6204E" modified="2010-05-18" version="1">MYGDLGTKLIQHAKRTQSLAYLPPYQREIVQAVTREVRDLDKDVSRILEQLEQARAAAEGEDGGNPPSSFNPADDPATACALLVDHLSMRRNKRCLLAYHRIRAEKIEEMCWNGIDPLEHQQRQREMESGNNNSEDHVTPRTDRTPLSNAHYNSSLTPVEEEYFRQYNEMLMAYKGHWTDVDLTGSLEPPKELYIDVRVLKDAGEIQTEYGATNHPRLPSTIKLKITLSSPKLGHVREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6H9</accession>
    <name>D4D6H9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023182.1">
        <property type="nucleotide sequence ID" value="XM_003023136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6H9"/>
    <dbReference type="GeneID" id="9583202"/>
    <dbReference type="KEGG" id="tve:TRV_02704"/>
    <dbReference type="HOGENOM" id="CLU_024117_2_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="154"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="463" mass="52242" checksum="3EC5735FD597FC8E" modified="2010-05-18" version="1">MVAEHLTVRNLTRTPVVLKLVERFNPPDGPKTLASTFTTMVNNITGTPAEIAAIQEGAQPFARQDVDVRVEPFTEARSDVRFFDKSDKERTRLTFEVEGDRYQIQVPVPTKETIVMKCLSPNPRFQFTGIFNPEHAHLALFSSANLNCWMRELKDDTLTSSLSIPGTHNSPTCHVAPPSVRCQAVSPREQLDNGVRFFDIRAHPQWPNDPAKDGLILAHSVFPISLTGQKTFRDMLGQIEEFLDRNPSETLIMSLKREGPGEHHDHQLANILKTHYTNANPSRWYTDTKVPTLGQVRGKIVLVRRFDIPDHLKKEHDGRGWGIDATDWADNTDHAVCSSGTLCIQDFYEVLETENIEKKIGFVHAQLGRSSECCYPLGTHKPDGDHCPYFVNFLSASNFWKVQTWPEKIAAKLNPATVDYICRSHKSDKGDWSTGIIVSDWVGKDGDWDLVRCIVGMNAKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6J3</accession>
    <name>D4D6J3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MAPKKK cascade protein kinase regulator Ste50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023140.1">
        <property type="nucleotide sequence ID" value="XM_003023094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6J3"/>
    <dbReference type="GeneID" id="9583175"/>
    <dbReference type="KEGG" id="tve:TRV_02719"/>
    <dbReference type="HOGENOM" id="CLU_021546_0_0_1"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="411"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59713" checksum="2A6A41A8B8289382" modified="2010-05-18" version="1">MAFADAYPGDSDADDEYERSVVISPHLAEDSEASPTDSEGPSTENTPTYGKTDDRISPKTVITDWTAEECAKFVGSLGLLQYREAFLENEIVGEALIALKHDELKELGISSVGHRLTILKNVYEAKVKQGVPIDPDHYVPLSADKSSTKDAATQDDIALLIQSIRRRDDRLMAAEAELRKLADDYRRLREELLPVFKIAKDKSAPLPYQPPSTVSYGGSTAALSESYTHDPATSPSFLGQEKAGSGLTRTISRKLFAGGSTPKTNSPTHIPQAIPEGRAFADSSTLDPSAAAMAASSHLTASMTSGQPSPKGMPSPTSPNSFYTQQTLASRSYSRDPPSSTNNRTAYDHSEDSQGQQRQDRSGNNQTSNSSSRQDHPAISTSRNGGSGGGGNQSSSNTQNSSDSGPSVEIFKSFRVSMDDPCYKVLPAALKKYNIHEDWRLYALYIVYGDQERCLALEEKPLILFKQLDKDGRKPMFMLRRQTQMVDGQVPGIYTSSGTTIGFPPSGSAFDPSTNNNTSITLGGLPSGGSGGQPSASLRSQPPQQNSIQLPGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6K7</accession>
    <name>D4D6K7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PT repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023154.1">
        <property type="nucleotide sequence ID" value="XM_003023108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583162"/>
    <dbReference type="KEGG" id="tve:TRV_02733"/>
    <dbReference type="HOGENOM" id="CLU_242782_0_0_1"/>
    <dbReference type="OrthoDB" id="4174196at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1647" mass="174817" checksum="64177C9617B05108" modified="2010-05-18" version="1">MTEAVKRTVTIAIRRPSKTPAVFVAACFTEPAWEPVELTPQLLSSKDAPTTEDSSTQVEEYEFSKKFELPEGKYQYKFRLGTDEDSWFCDNDVETVVNDDGICNNVLVVNDTSSTSATEGSQQTNGTPNGTKLKEPAKEEDDTEEKAKIMEDIPVDAAVVDKSDKEVPVNVVGETAPEVEKQTDNQVDSVGAPEASASKGNISEEKSDENLSKKEDTVPDSEKTVSVDTTEMEQEQSSSDKLENTMPESTSKELPEESKESESRAEVSQNNLEAKKELSEKFDAVEAIDPAETIKEESNDKVETPLVTESETTVEEPKNNTAEDLKTAPAAPENDVLQAEVAPEAPAIEPTEDSTKEDSLPEATKKDAVPAHAEEPVAEKANGSAKETANPVASMVVEEPTVIEPEAVSEEKSKEEPAAELEKTPVKAEEMAESISIPAVEKAAPSPEAIKEDTLATKEEPVSIEPENVELPQEEKVSDKNADLVATEDKIKEVSAAESEPVPDAVKADSEVAAVREAEASVEEPKEPIVSKDIASKEIASDDAPGPVSEKPAVANEEQEKSSNEPEAIPEKPKESAPELEPELTESKRDTDATENSTVDGLETQGDPVNTEPEVMPAAPDKVVSTEDSEVPSSKEPEPVIEAPENEAEASEEISTEKEDGTTENAKKEESPLSVPMPEEAKDGAEEKTEPVPAPVATNEVEDVTGVVDELSKEADTANEEPDKDASQPVEDLKSTEDDAPVVKEAETITDDKPVEESAPEVLKDNTKEESQEPAPGPNAEIAVAADEAPVNEHQDIASIEEVKDLSADDPAPADCNVPAVEDEAVISESKDTLEPEVNRDSQPIEKKEETEDIADPVPVSAPGAQPAAEEDPVKEVPSQKEDETKEASEVPVIANIAGVEALQNVKSQANPELSEEEAGQVAQSSTPAPEPQVEGETKASELKEPATEELAPVAEEPAAAIQKDSESGDSKEEDTSAPEKEVEAAGEQTNKPEEQKLAEPEATGDDAPIPAAAETENKEIDLPSKSIKDEAAATTQSSTSQVTDEPSDKPAPVASEGPGEPDVSQEPKEVHVETAVVEDASKEANAQSQVEDAAVDAPIDVPEEPKQDAEAVVNVEEAPKDVQNDVTATGEEVKSEAEKSLDHVVKVDDKRAEEAVEEAPVAVEETVEAESAPETVAADPVADETPAPEPEAAEEEAHKTETADVTTIEEKDVLPEVAETPVVPEDTEKENVTVEAEKPEIPTSEAVTTLPGSLEAPKDTEETPGNPDKCAATEPVTHNIEENTTVPENVPEPTGTGSASEGTTNNPAESVADNEPEVPTNKDKVTKEAILDEQLVGSTSTEGKNDPKADLPNVSADSIQEAGLQGKLQSTEAKPDFVTDHAKVEEDQPKESSTSKTEGQEDAHKTNGATIAAALGAAAVVPGAAFLAKKAFESGETTDKKTAADDTPEGTESLISKKGTVDDSEHINNVMAKEDSKVGANDESSNGTKNGPMQEEPATAESTSKAHATEENDKGTTIENTSLPEQVKESPVGKDDAQETVNGKVIANEESKKATPETSASADIEPSSSSATALANASTAATTNGTKTNGTKTNGVSEETRPPTGNKSITSLTSQRRDNFLKYIWRAIFVNFFGSLFGFRRRDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6M5</accession>
    <name>D4D6M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000144">
        <property type="protein sequence ID" value="EFE42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023109.1">
        <property type="nucleotide sequence ID" value="XM_003023063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6M5"/>
    <dbReference type="GeneID" id="9583129"/>
    <dbReference type="KEGG" id="tve:TRV_02752"/>
    <dbReference type="HOGENOM" id="CLU_032142_0_0_1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000649">
        <property type="entry name" value="Compass component swd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45046" checksum="78268920327E5D9F" modified="2010-05-18" version="1">MAHEYGRFDLKLPYILQNCIHSTKFHLSWLFVASLFEDQPVLVDVSSPRPIKRILPSAPLRPQPENGEEVDPAVAAKQAAQDAKHSTCVTVFTALGNHILAGTSKGWINIIETQTCKTIHSTRLCNGVIILLRLASNGRDLLANSSDRVIRTILMPDLSQLGVSLEPSNIKLDIEHKFQDVVNRLSWNHVAFSATGEFVTASTFMNHDIYVWERSHGSLVKILEGPKEELGVVEWHPNKPMVVACGLESGGIYVWSIVTPQKWSALAPDFQEVEENVEYVEREDEYDIHPAEQVHQRRLDLEDETPDVLTIEPVKGETGDDGHETFRMPVLLDISDSESEEDIIAVGPGTMRRRSPGSGREWMNNNGGNNVAASATASGDVYDSDGRRQPTSNGIGRTQNKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6V3</accession>
    <name>D4D6V3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023009.1">
        <property type="nucleotide sequence ID" value="XM_003022963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6V3"/>
    <dbReference type="GeneID" id="9583029"/>
    <dbReference type="KEGG" id="tve:TRV_02830"/>
    <dbReference type="HOGENOM" id="CLU_085155_0_0_1"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="204" mass="22204" checksum="29D82D376ECCE5FE" modified="2010-05-18" version="1">MASQAGPTPLPATTILKSERISQAEAHEFLTAYLDRAASDPGFQPDSTLSPQGPIAAGVGSSPNLVIHNLKRVQAGLAEEVLGKDLIYAKLENEGGAAGGIFELHSHNATDGQNWAGKKRETPAVSGWQDLQSYEREQTDIVEAGDGDDEVVAVEDNTEAVEDVQEGKIDKEERKRQKKQRRKQEQKAKMAAARKENEDDETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6W5</accession>
    <name>D4D6W5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023021.1">
        <property type="nucleotide sequence ID" value="XM_003022975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6W5"/>
    <dbReference type="GeneID" id="9583041"/>
    <dbReference type="KEGG" id="tve:TRV_02842"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006523462" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="213" mass="23306" checksum="C1E59BED68E9410B" modified="2010-05-18" version="1">MARIGRILTLVVFAAVALFLFMGQTVEAKGPKITSKVYFDIEHDGQPLGRIVMGFALATGEKGFGYEGSTFHRVIKDFMIQGGDFTNGDGTGGKSIYGNKFEDENFKLRHTKKGLLSMANAGKDTNGSQFFITTAITAWLDGKHVVFGEVLEGYDIVDKIQVVPKGFQDRPTKDVKIAKCGELDMKEEAEGEGTESPSKPDSEKEQAPVRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7T0</accession>
    <name>D4D7T0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin-specific chaperone D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022703.1">
        <property type="nucleotide sequence ID" value="XM_003022657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7T0"/>
    <dbReference type="GeneID" id="9581361"/>
    <dbReference type="KEGG" id="tve:TRV_03164"/>
    <dbReference type="HOGENOM" id="CLU_003043_3_0_1"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="434"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131185" checksum="95D25BD153B5AAA8" modified="2010-05-18" version="1">MDAVHDRDIELQRASGELIEEFRTKLPPLLWKHPNSGKRVVHRWARAAKVEKLILLLDPFQEWPQLLDPHLNWILTHLTDAFLSYLLGHGHSYGSVTKIKEPEMIYPLARAICKIIYTLCKVRGPKVISRLFSNEPKYLEPMLSMFIEWDSIVSADINRSTTTGQGLPLNWEERYVMLLWLSHLLLAPFDLTSISSENISIPYQNLSPFSDLSSKTPKLALAILSISLKYLVLPGKEREGAVLLLSRLALRKDMQQLGMLKSLVEWALGHLKPGLEITPPSTFACIGLLSFIAKLGTLAQVEDIAPFVRPIFSQALDLSRGSCDMSATVQSSASTRKLLTKILREMNTLSLTLEKRPDLLQISSNEVSTILEDTIDYFLLAVGDKDTPVRFAASKALSMIALKLEPDLGADILDAVISALDEDVLYEEESGELIPKEKARSMMGRLILRSFKSVDAQKWHGLMLTLGHLLFRRSPPLDRLFQLFECLVSGLTFEQRSSTGASIGVTVRDASCFGIWSLARKYSTKELDSVEISTTENRNKCLLRSLAIELISSACLDPSGNIRRGSSAALQELIGRHPDSISEGISIVQVVDYHSVARREFAMTEVAIAASKLDKVYWSPLIGGLLRWRGIGAPDPKSRRAAALAIGELSLQMSYAGIGTVLDRILHTLSLTSSNSVEARHGGFLALSATVDAFLRYESSKDDTPEDPGPVIELSRRIHQLWGIFSSSSGPSVEGLTLQEYRPDLTAEACSRLISSLARSYTLFGSDVPRFGLQLNNDSLEMTVTILLLCVQRSDDEAVAASSQAAVDIFAILSVERKSAIIQEWLSEVQSNRKKTTGSGQIAALGAVYRHSSSDERERKLILDELMRCSGPEEAVIVKRVSAVRCILTGVLPYLDNTDQLESHIGVLLNDYTTDNRGDVGSLIRTEAINGVHMILASRLGNPIGHSNVHHLMKHIIRLAAEKLDKVRFKAWKCFEVYWESDTGLPPLETRFDHFSEVSTVAYFSQLITLVQVEWLRLPLIKGLVTSLTAGADSLIISSRTAVVEFINSQNDNTRYRMQRDIFMSLLIVLEENITDDRYAIPTVESLAFLIENCFNPEILELDPDVEDDKNAATPLPQGMNYFIFPYSNNILTNAKIRALTSEYLFIQTGNKPLKTENWMQPPIQLKATVDNIVQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7U2</accession>
    <name>D4D7U2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022715.1">
        <property type="nucleotide sequence ID" value="XM_003022669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7U2"/>
    <dbReference type="GeneID" id="9581404"/>
    <dbReference type="KEGG" id="tve:TRV_03176"/>
    <dbReference type="HOGENOM" id="CLU_010834_0_1_1"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="428"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="761"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="850" mass="92140" checksum="FAA91BAEF38BFAFA" modified="2010-05-18" version="1">MAPAARAARASKGQKGSSSHPPSTSSATTNEDTIKELPGDGMSKAAAVTEVARESISAASSAASQRSRSSSSLRSTAISSRPPSIQFTKGVGISARSLPAEVATTKVNIASTEAPSMPTPNISNNIARNVHNGLKPSEGTDKVEGEPKEDETPQETQAIEQKKGSPNAPSETTVDLPQKEINNEKPRSIGWFEWLSMAKNTNEPTPQSSDPAIVKEDGSSTPKVGLEDTCSTIKEDINQHDTSGLKEVRASQSRSWLQLWGGSNATQAKPLEPISNPQSAENTTTTPQSNPQEESISQSQPEGVSDKNQPAEDATHKRGESASGWLFWPRQQADIGSSAKKGENASENVPPDENTKEQMKGASLAAETQNIPSSKNSRVKPSTAIPQAATPPEPSSQTVPKEPPLQPANVPVAPSTKKGERTPPNQVLPSFHTSFPLESKPSFIEQLSRLLYKKGSEPRHVLRSQTTPQIKKAIAIGIHGYFPTPLIRTVIGQPTGTSVKFASMAANAIQEWADENNSPCHIEKIALEGEGRISERVDLLWKLLLNWIEHIREADFVLVSCHSQGVPVATMLVSKLIAFGCVSCARIGICAMAGINLGPFADYRSRWISGSAGELFDFTDAESKVSKDYRAALKAALDFGVKVTYVGSIDDQLVSLESSTFTTVSHPHIYRAVFVDGRVHAPSFLSHLVGFTMKLRNLGVSDHGLIRELSSPLAGSLYTGEGHSRLYEDKDVYKYFTPSFFASTEPKTIYVQFTNGLTASRLAIRFTLETTVISNAAIQFHKMIAPTASTSTANPYILPFAMRGVLEEEYVRHELSDETMELLKQFEDWKPSTKTLKDVKFRLEGIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D866</accession>
    <name>D4D866_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein (Nab3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000170">
        <property type="protein sequence ID" value="EFE41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022563.1">
        <property type="nucleotide sequence ID" value="XM_003022517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D866"/>
    <dbReference type="GeneID" id="9581233"/>
    <dbReference type="KEGG" id="tve:TRV_03302"/>
    <dbReference type="HOGENOM" id="CLU_013226_1_0_1"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="447"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="913" mass="99686" checksum="3BCAD13B40319BDF" modified="2010-05-18" version="1">MASDPPEEALHFRGKTLTPESPRPLHIAEPSNIPLLQNQMDASYHDTSALETVPEVKEHTLNPVLVEQGLQRPAVGDQMQMVDQTYAMLQSGLEQMNASAAGSVSGITGSLPGSNAKTESMLSENESILASTTRDEVLTNSLSSSVPHPNPTAEPDLQHHQTNPDTAAHTHMVGTVENNSITAAHLAPTYPATQGVAPLYGAYQHQQQPPPVRSTPATGYPLASAQNPGDVNSDISQSSLLDTAAAYQSMLGSNVPSSASYITTAVTTAAAAAAATTTTMPTSAAHATEPISQPDHTLSDIAVSNMPISYASTYPSRPLATSHENEPMQTSHLDTSPDTSPSKETLQSDKRNNLPQRSAAMDASASLSSSLSSPEVLQQVPPKSHTRKVSNTSRKRDSYDENIESTKGDPQEDTPWGPDIQKKYDDFLRDERIYVTEAHWDRFPAGSRLFIGNLPTERVTKRDLFHIFHMHGKLAQISIKQAYGFIQFLEPDSCRKALQAQQGSTIRGRKIQNRHLEVAVQLRTDMIGVPEDWQSAISEKRTHTGTVIEVHDLLHPEAHAETRITPENAVLIDMILERGGGQGPDHLGLEMHAIVALVQGTKGMTANLTCQFQGEIRVTSRRSRLLFWKMQTSWSTPFTQVFRCQRANRFTSEFVYRVENAFRDRGLRCDVLILSPRIRLSAVVRRQVMEGVLAIVRISRANQYSGKIPLQIFDRSGGMDNVRFNEYSELDLSLAAEVVVHARNSQKPNPIQLQPPLLPAVLPPQPIPQPVPAQSDQAAIANLLSNLDSSTLHTLLSSLNQQQQLQAQQAQQQNRQFHSLPVPVTAPPLNSTNLAALLGNLTRPGNANPPSVPTTTAPGTHFVPPPNPIPHPNTNLASLLPKGPNPGQNGPLPQPQANMQVQQIMEQLMKWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I6</accession>
    <name>D4D8I6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022472.1">
        <property type="nucleotide sequence ID" value="XM_003022426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8I6"/>
    <dbReference type="GeneID" id="9581049"/>
    <dbReference type="KEGG" id="tve:TRV_03422"/>
    <dbReference type="HOGENOM" id="CLU_059400_0_0_1"/>
    <dbReference type="OrthoDB" id="4907280at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056082" description="Phospholipase D" evidence="2">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37587" checksum="1C3FA24FCD81BC93" modified="2010-05-18" version="1">MVSLLRLCSFLLAAGSTLVQGSPIIAPSIPPCEPPSNFTGPSNFTSKPGNGASPFWLIAHRVLTKDGVKAALGHGANALEMDITGWWSGWFGDHDGLLTSAGDTVSDWFDEIASRRTQGDPVSFVWLDLKNPDFNKNGVNIVSLMILCREKLEKVGVRVLYGFYSSQTNGPSFKFVKQVMNENEAIGIDGKFETVEKDFEEKGIPLQKRVFSSGLFNPDFNFGNCEVHSSGVCAQLREGKESHEFSKVFGWTVSSYTRKDHVYKMMEVGVDGLIYGFVASHYYDHADIRHTLSTIRGWLEEHKDTHRLATVDDNPWSSMSKKGSRKSSWVKGEVPSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8J2</accession>
    <name>D4D8J2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonsense-mediated mRNA decay protein Upf3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022478.1">
        <property type="nucleotide sequence ID" value="XM_003022432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8J2"/>
    <dbReference type="GeneID" id="9581055"/>
    <dbReference type="KEGG" id="tve:TRV_03428"/>
    <dbReference type="HOGENOM" id="CLU_018549_1_0_1"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="659" mass="69212" checksum="F87B8603EF1D8155" modified="2010-05-18" version="1">MLQHDLAWSTRRCRRQLPSAIAHAFTIHQRHRAETELEEKPGIAVLLIDLPPNTMSQKNQQKASPGVLAINPAATQKAAPPPTPKGHSSKGNAPRLKLHVRRLPPGLTQAEFETTLGDCWKVGRGKVDWFLFKEGKVSTDPSKPSRPGRAYLRVTSSVTIPELSDVIRQTTFHDARNTYNDSALLGPPTLEYAPFSRVPSGKVRNDARVGTIDQDAEFIAFLESLTNPVTKPSEEETTEAADKVEKPTITPLIQYLREKKANKAKEVAAAKAAKQARSAAAKESKSEKSIGKKQLLSRADKSTSEKQKKDKAAKDVAVKDAVKAANKQAANGSAKAENKALASSVNQPSQASPAPERKRERGSLTAATKILRRDLGLTTPTRRRDKAGQASSSGPGGNATAESAKKDQQPSSSKLESDNPAPTPKGKNAADSTPKSAPSKQPKGTPPAEPAAARNNAAGKKAATTPSTPNTKASSTPAAQKSQQQSSQSPSSNGTQAFLKHANPSQGVTEDLLQKGFSQFGKVIRVEIDKKKGFGYVDFAEPASLRKAIDASPVSIAQSQVVVLERRTSAAVAQNRGHGNRGAGTGGGGGGGAGQGPTHANTQQQPSQQGSRPAQAGSSPTAAAAPPPTTSPASRGTPGPRGRGSRRGYGRGGAGGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K8</accession>
    <name>D4D8K8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022381.1">
        <property type="nucleotide sequence ID" value="XM_003022335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K8"/>
    <dbReference type="GeneID" id="9580980"/>
    <dbReference type="KEGG" id="tve:TRV_03445"/>
    <dbReference type="HOGENOM" id="CLU_880519_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="316" mass="34817" checksum="E5EA6F57CDDAFE53" modified="2010-05-18" version="1">MKSKRENSRLTHREEQLWGLESRVPRQPAVNKPALKQAHKAITLGRKREDSGRTLDSVQLRRGEARRASVKGLAEVKVKKILEATKILSRAKEKKKKKKKRKKRTKGGGDGLLGQMNERRRMRQGTAETASARRRANGVDEEEVEEEEGGRRRRGGGGEEKEISGGVALLFFCLRAGGSAWGRPLFFLLLDHQTGARTLGRTTTRYGYYYCCCCCCCCCYSLPFRSSKARAGGVDSGQVARSGGEGSVPVGRQRVRDNPPPLVGRRLCAGRRGEGDGKDPRPVLVIGRRVEGGPVSYRNSRVVTGAETASQQARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X6</accession>
    <name>D4D8X6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022353.1">
        <property type="nucleotide sequence ID" value="XM_003022307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X6"/>
    <dbReference type="GeneID" id="9580900"/>
    <dbReference type="KEGG" id="tve:TRV_03564"/>
    <dbReference type="HOGENOM" id="CLU_005610_1_0_1"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="985" mass="109172" checksum="1F922ABB51D74C1E" modified="2010-05-18" version="1">MSRMDDTVRPHRPHRTDTSNEIKEPTYARTGSPNNGNSSRDEVSTRPHKPAPSKLLAEDLIIELAQRAVDSGIQDTKRSLAGSEAVEGVVRPKLTIDLGHANIARVPEAVVNIIKDEVASRLLTKEKIYIFFRLSLSNNHIDRIPSRFSECIHLRYLNIRANNFTEFPRVVYSLTFLEILDLSRNKITKLPEEVRNLSSLRVFSIMQNFLEDLPSQLADMSKLQVIKVSGNPLNSSLKAVLELREADVNHLEMADNEKDSAITTELKRFLKSRRAAASPEPEYHDQSETTEPPRPPKRGNRFPVIPRSNGTDSTSGSRSPSLSRPPPIPTRSHHRMASGQSGLIHRSNTLASVSERNRSNSEGFIAGSGTSRNKRMGLISRKNTDLGTLDEMRPYRNSHLRGLSHGSLLRSQRGGMPNDGSNSSSPSSPMDRRRLKDGFVHRLSSLPEQRVKTTTKNPVVNSARSVLYALYQIHPHISSLINVIKAEEYRRSSLEIVFYNATTHLDQLNEALQNIGDADLQDKEVAKRVTESVKQECATCITAYTHVGTQLRANVAKAVALSDPKYIRTLLLMIYGSLIELRNAYAVFNVKPKPRRSKMAKKLSITTTNQPMSKFIPERESEPSVTPTRERPPTSRRLRSETTVHLPPIAPFPTALPPFTPHPPGHPSHSAHPTAPPLTIGGRSRSSSRSNAFLHSSGTSSIANTPRSGESFNLLQTPVNNRINPVTGLDEIEEDRIFEKIFIQLSSAYKATLQAVPLAAQQFSQCLKAAEESRAPQHLRNLCRKLLGRCRSCVDVADALDNRLSNMKLKEPGGNLRNQREFWHLCKTFIQTFVELVLDIREAKTFCLLPSEIVATLRIVQKTIREAGRLIDTSPWSYLAELHTSNPSNAVSQPQPNGHLHYSNSSTLIVSQSGLVNGSSPQSATVPATPLSAALGPAAQATVPTTTTSSNTSNTSGDRMFAGDVFQRADLLLSMAPSAPLFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D930</accession>
    <name>D4D930_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022296.1">
        <property type="nucleotide sequence ID" value="XM_003022250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D930"/>
    <dbReference type="GeneID" id="9576899"/>
    <dbReference type="KEGG" id="tve:TRV_03620"/>
    <dbReference type="HOGENOM" id="CLU_022769_0_0_1"/>
    <dbReference type="OrthoDB" id="5383338at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="787" mass="85826" checksum="0B26BF14E37C83FB" modified="2010-05-18" version="1">MPDSPEGQFQLSPAMQSSNKTGQSSINRSSGNGNINASMRAHRPRRTKSPRMSPVLEDTKVGGQTEAVILRIIEDTNSIIPSQQARTEPNYPNNTASREDKIFVFPQPHRRVSPSPSSMSRSSMPKSVDSQSPPPVPRLNGNSQHKFAVFPPPRSSTPNRSKSTTSSSRKRAKTVSSTNSQGDSTPGGWSSPSTSEGEPRDVGNSPGQDNSSPLPPPPPPPMRSIFPRYDPDLPLSQQRYYPNAGSPRSSSDQAPSRADYGSLSPPSTSACPSSFTSVDGPMIAPVESLERLWNATCGESSGSDAGTFHLNIRRIDSFTYNIGAGSVAFYTLKTDTISDFELHKTHPTKPNTKSPVVTLNLDHIQNRSSTTIPIFPKLAEILAREQSLELARQNKLSPVQAMEAESAAVSQVKAKETCLFEWQDAQSRYKLHYQAMMNSSPATPGSRPQSARSSVPTCLLNASVSNSLPPFGGPSYGPTVVVSVSNSGSSSRGTDTPLAAVDLEHMTLTIFSNDILSAVPSLHSIDTLVAAILTVTVSNETTKQVLESIDIYAPKPEEFPDPYRPPTPSPASVLANHTPTNSNGSANEHSNPISTSTSTPNNKPACIEEERRYFTPTGKQIFTTQAEREEYEQEAELMAQVRRNQRKPKRNQSVSSWKWPWKRQPEVEEIDLEAGIGRSSNAVKQQQQRQQGGGGHDTTTTTKQQQQEQQKKKRKPTLVVEEIDVERYGRYADGTPRAGEKLPGPTRAALRALFWFFSLIMWCLTACVKGVAWTLVSLTQCVSGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D942</accession>
    <name>D4D942_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022229.1">
        <property type="nucleotide sequence ID" value="XM_003022183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D942"/>
    <dbReference type="GeneID" id="9576831"/>
    <dbReference type="KEGG" id="tve:TRV_03632"/>
    <dbReference type="HOGENOM" id="CLU_3260410_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="42" mass="4768" checksum="35A1C0B56B8E5FA9" modified="2010-05-18" version="1">MAGIRYQRTDAEEEEDEEGSTMDAVDEEEDERERSEGEGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D961</accession>
    <name>D4D961_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022248.1">
        <property type="nucleotide sequence ID" value="XM_003022202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D961"/>
    <dbReference type="GeneID" id="9576850"/>
    <dbReference type="KEGG" id="tve:TRV_03651"/>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="538" mass="59926" checksum="170CD042FA27A4FD" modified="2010-05-18" version="1">MSPLWGLRHNGREEGREDGDEEEYVGETGRPDNRRRAQDVDERTRLLPAEGNGYLHPDDPAVSPYNLWSVRALRGLTLTVLFISLLWWILLLISIFVSPPGMSNRGSGFFDFSFTTLTISNLLIALIFFAIPSTPMTIWATTLSVLLSVSLFLMLGVPRLRIEEGWVGIASAAWAVVISLYLVAQTRLVAQGKRQEEERLTGREETRRSLAEWLAILVQIIVMAVTVLVGILLMSTLSLRAKDATLEAPGQRYYVDSNKYQVHLHCIGGDHSTLKNSNETTVTVLLEGGESPVEYTFQKWVDEAYQHGVIKRYCYWDRPGIAWSDNAPSPHSAGMSADALSEALAMADEEGPWVVVSAGVGGIYSRIFASRHLRDIHGIMLIDTLHEDLLHNLGKPGRGLMLWIWGILSPLGIDRLAGAIFKGRTRADRVCGMRAYQGGKFIKAELQESLVADSITRSEISSARHIQSPSTPLVVVSSGKEVRRSQTWADKQEDLTKITKNLVAWDVVKGAPHQVWDTLDGRRTLEKRLGELVKQAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9A4</accession>
    <name>D4D9A4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, zinc-binding, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022171.1">
        <property type="nucleotide sequence ID" value="XM_003022125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9A4"/>
    <dbReference type="GeneID" id="9579065"/>
    <dbReference type="KEGG" id="tve:TRV_03695"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="377" mass="40731" checksum="6C333CB3262DA13C" modified="2010-05-18" version="1">MASKAATPMSIPKTMRAWTHQRAGSPSKVLSMKDDVSVPTPPTDTSILVRVSHVAFHPGVIILMHFIPSWLRRMPAVPETDFSGVIVRCGKDVPISNGSRDFKPGTPVFGSLPVKPYLGTGQGALAEYIAIEAEAIARKPTNVSFAEASGLGVSAHTALVLVEAAEVPKDARILINSPCGGVGHFATQLLRHRNPTARITGICSGHNHALALQLGCTDTIDHTSFPNAGGQTLVQHLASKYGNDEEKFDIIFDAYGSQDLWISSSKYLKPGKDHPYVTVGPKMGVSIMEVPGFLWKVIMNSTLPTWLGGVPRPYKQISAFTNTEAIEKCRELALAGEFNTHVGETWELDQALSAYEVMSSGHARGKVVVKVWEPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9H9</accession>
    <name>D4D9H9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000194">
        <property type="protein sequence ID" value="EFE41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022105.1">
        <property type="nucleotide sequence ID" value="XM_003022059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9H9"/>
    <dbReference type="GeneID" id="9578989"/>
    <dbReference type="KEGG" id="tve:TRV_03772"/>
    <dbReference type="HOGENOM" id="CLU_072144_1_1_1"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005624">
        <property type="entry name" value="Ni-bind_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="198" mass="21311" checksum="10F0DE1F03C97BF8" modified="2010-05-18" version="1">MALRDEYNIAAVTNDIFTREDAEFLTRNKALSPSRIRAIETGGCPHAAVREDISANLLALQQLQRKFKTDLLLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVVNKIDLAEAVGADLDVMERDAAKMREGGPTVFAVVKQGKGVEHIVDLILSAWKGSGAYDVSLERWKNGAPKNSGSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9L1</accession>
    <name>D4D9L1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress response phosphoprotein phosphatase Psr1/2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022063.1">
        <property type="nucleotide sequence ID" value="XM_003022017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9L1"/>
    <dbReference type="GeneID" id="9578947"/>
    <dbReference type="KEGG" id="tve:TRV_03804"/>
    <dbReference type="HOGENOM" id="CLU_020262_2_0_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="341"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="515" mass="56579" checksum="5891557DC58227CD" modified="2010-05-18" version="1">MPHNASPSAPETTEHPKKKRSFLRIPSRSSSKKNKEHSQSEDTNREGTGASLSTSQTNLTGSHSKASSTRSRHAQPLDQAGPHIGSKNGGSRAEHDPKSDRKQRGSLWSFLSCCRAPKDDDGEDMASLPPKQTVKPHSLRTTQPISEKADAGVADSGSADRKDDADATTEKPAIKIFDDQSAPIAENSVGAAVDEKAAVTTKQEDEEESTLSGRDSNTHHQNEPVLPESSKLDPVHVLSEESGASNSLATGQTEKPTETPATIPEQQNRSDETDMHDQYPIASADEPAAEANHQIVHQTPLPPPPPLDLAYPQAASDKPVPPVPSVQSEKQKWLLPPIQDHFSGRKCLVLDLDETLVHSSFKVLDRADFTIPVEIEGQYHNIYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDKLDIHKVVHHRLFRDSCYNHQGNYVKDLSQVGRDLKETIIIDNSPTSYIFHPKHAIPISSWFSDAHDNELLDLIPVLEDLAHSHVRDVSLVLDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9R3</accession>
    <name>D4D9R3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022039.1">
        <property type="nucleotide sequence ID" value="XM_003021993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9R3"/>
    <dbReference type="GeneID" id="9578923"/>
    <dbReference type="KEGG" id="tve:TRV_03856"/>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35810" checksum="F10FA59FC4938729" modified="2010-05-18" version="1">MTEAIKLLFRKLYHPVGFSKGYNFILFFVLVGALMGFTLARFQYLNIRGDFCKRGNAAPGECFYYLQQTRYHVGIILHLGCILPASFLVCFQFVPIIRHKFIMWHRISGYLIMLLVLISNVGALVIARRAFGGTLDIQAGIGTLVLMTTVGIGLAYYNIKKLQIDQHRAWMIRSFVYMGAIITNRFIFSAAAAIITAIGGYNAVWPCDKLDYTLGHNETLSKYPACSTFYDGSNPQQQAIVVADFNGGDENVSAAIGLNFGMAIWIAILIHAIGVEVYLTPGESQRLRQVSYQRQLEAGYRMPGKAGLTAERLGDCSGMQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA83</accession>
    <name>D4DA83_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021852.1">
        <property type="nucleotide sequence ID" value="XM_003021806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA83"/>
    <dbReference type="GeneID" id="9578734"/>
    <dbReference type="KEGG" id="tve:TRV_04029"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="316" mass="35053" checksum="812D6FD768085986" modified="2010-05-18" version="1">MQARPDTHYFTPHDYRLWCQRFAVGLRKSGIKTGDRVLLFSPNDLFFPVVFMGTVMAGGIFTGANPTYTPRELEYQLKDSGAKYLLCADGSLDTGIAAAESIGMGLDRVFIFNSAVFDGTGSGARGCHYWGDLIASPAEGSRFVWESLSAPGESNQTLALNYSSGTTGLPKGVEITHRNYVANLFQFDHTGSLHHEYTNKTARSRWLCFLPLYHAMAQNFFIASALRRGIPVYIMARFDFVQMLENIQKFRINEILTVPPIMIALAKHPLVKKYDLSSLESIGSGAAPLGREISEEVESMFPPGKLNVRQGWGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAT6</accession>
    <name>D4DAT6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021654.1">
        <property type="nucleotide sequence ID" value="XM_003021608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAT6"/>
    <dbReference type="GeneID" id="9578615"/>
    <dbReference type="KEGG" id="tve:TRV_04234"/>
    <dbReference type="HOGENOM" id="CLU_047725_1_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="326" mass="36291" checksum="DE7F31964FB735AF" modified="2010-05-18" version="1">MWRIPIDTPQVAVPNGLKLAEVTVDTPLDEVFKHWKESGGVILKNILTVAEANQITTELESRLNSVQRGSLVPHADLAAFHGTKTKRAGDIINHSATFREKILENDFIHSICKRCFSEGGHNGDYWLSAATTLNASGPQPAQVLHRDLTSYPPYAQLGPEGTEPQINFLFAFSDFTADNGATRLIPGSNKWPFDQRGNMEQTIPAEMKTGDCLLIGGKVIHAMGENKTETERKCTQLTVIPSFLTPAEAHPFIIKLETVQKLSKRAQRFVGFRSQYPRGSPGLWTKDYIELALHLGLDDLQGAMEDLQDVINQPKHWDTMDYQKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAU5</accession>
    <name>D4DAU5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021663.1">
        <property type="nucleotide sequence ID" value="XM_003021617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAU5"/>
    <dbReference type="GeneID" id="9578624"/>
    <dbReference type="KEGG" id="tve:TRV_04243"/>
    <dbReference type="HOGENOM" id="CLU_005062_1_0_1"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="280"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="957" mass="104957" checksum="64C6634875A38A53" modified="2010-05-18" version="1">MAVDKPETTQGSIEMEVSPATTSPDPPPVPQHDEERNPLPTDSMVTVPLSDIQRGSGISGEGPMLPDAVYCPETAVPVGLGLDSPDETQHDGEEDAEELETASELQAEETPSRAPSRAPSIASSKAESIGGSSKSDMDDGRSVDWAGLEESEVNKSKASGDDVAPQDCFEEAIEDCNDCLADREAEQSTTLLLARLEQENNALATDPKSASAKKASVRNSRPPSIQKLKDLVNDPRSSLRYSQLPAPQMTELEFWAALVADYPRTAQRLPTLTSHKIRGGVPPPLRGVVWPSIAGARDSHLHDEYEKLCGETSPYEGLIGKDIGRSFPNVEMFRDPLGEGQQMLGRVLKCFSLYDSKIGYCQGLGFVVGPLLMHMSEAEAFCVLVRLMDHYDLRSCFLPTLSGLHLRIYQFQSLLSHHAPELYAHLDSLKIEPVYVSQWFLSFFAVTCPLPMLLRIYDVLLLEGACETLMRVALSLMQRNQHRIMACTEFEDAMQLLLSRSLWDPYACNADDLVTDFVSLTSLVTHESLHALEVKYQEAQGAAQSVSLPQLQAIASRFLGRLWAGSSSHSSVKSVAQSPGIPTPGSSPCMGVTRTPSKQSMASTLNFLESSTSEASTAPTEASTLSSSNIDNATPKPKPHRLQTSDKDLHSQIEDLLLALSDMQREQAALAKRLQQEREEREEDQMVAAQLLSHMKETPAEQPDPKLILKAEERFASTEPRRMSMLQTKQQLLDDVEMWKSKYELESTRCQDMGRTIDEHEQKNAQLKEQLKEARSRVQDVHKEKQRLERTVQELRAKKPPLSKLQTDRPESVGSGDDGSANGLREFKLGKASSPKTPTFSKRTSSLGAPKSLVGDEEGLLIELVNAKTSEAVARQELEEMKVKLDTLKRLMSRSTNATSPASTAGDSSPSILVTASKSSPDTTAPPKSQNSSPVGFFTGWTRRTASTTSAVIPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAY8</accession>
    <name>D4DAY8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021613.1">
        <property type="nucleotide sequence ID" value="XM_003021567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAY8"/>
    <dbReference type="GeneID" id="9578574"/>
    <dbReference type="KEGG" id="tve:TRV_04286"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="523" mass="56942" checksum="6478BEDC13F4AE43" modified="2010-05-18" version="1">MALGQSEEKIVSQVENRPVNHHYDGEAAARPDQDAADMARLGVAQETKRRFGLVTILGFTTCIMGTWESGLPFFLTAYINGGPVTMVYGFILAFFGSLATCASLAEMALMYPISGGQYYWASLLAPPGKVKFLSFLTGWLSVLGWQSASTTGTYLGGTIIQGVVKLNYPEYTPERWQATLMLYAVLILSLSVNVSLVKWLPGVEGVILIIHVVGFFAIMIPLVHLAPISSAKFVFTEFINTSGYSSSGLSWLIGQSASAVLFIGYDGACHMAEEVQNARINVPRAMFFTMFINGAMGLAMYLVILFCIGDISRVINTETKVPFIELFRNSTQSNTAATVLTSLLITTYIVANFNFMASASRQAWAFARDGGLPFSHLLRKIDRKRSIPLFAIALTGVLNALLGLISIGSNVAFSAVVSLVVSGYMSSYVIVICVMIHKRLTHGKIEFGPWNLGRYGLPINIVAVIYTTVTVIFAFFPPSVPVNAENMNYSGPVYGVVVAFGIVYYIVRGHKTYTGPKLPRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB55</accession>
    <name>D4DB55_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021507.1">
        <property type="nucleotide sequence ID" value="XM_003021461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB55"/>
    <dbReference type="GeneID" id="9578455"/>
    <dbReference type="KEGG" id="tve:TRV_04354"/>
    <dbReference type="HOGENOM" id="CLU_030828_0_0_1"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="524" mass="58860" checksum="3E05B190F4566932" modified="2010-05-18" version="1">MRPEAALAKLTLHSSIEPTITLPFMFALERIILNICAFYPLKLRTMTSQAALIDETIVGLKRALLRHASDAAYDDAINLPSNRGNKTRLNAEFVREGALGYMNHEQFYRKKAEHSGYTRDILESNPPRFDAEGDELDFDDSDAAADAEAADDNPFSSTHLDGSFPAYNDGIFVTNLYSAHIDLLAPLTHPSELANHSMANAYTNKAITTMIERINRRLRLERHALWQAKNVYRQLVADSIWMPCGAVERDDDAELFGASNPQSIAQEPSVSNSTVTASSDRMNVDQQNDNNGDSSAGNDRNNDDSRAERPDETTDNTRDPDGDIVMESADIDDGEDKGGRGGGDESEGDQAEGSPKDKDKELTDDGFLHPRRMTTRAQVSANQNTVSQEKQDEKEHEILSLEVHPIFRLPRLPPEERNCGLTQSEADETRRMLWAYIQKQGESVRLFTEMLKMLRKSHRMKEEVWEWCKAEAHIGELSDGEDWYDKERWGLGEGEDLRKGADEEETEGLDEGRPTGKRGRGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA3</accession>
    <name>D4DBA3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021555.1">
        <property type="nucleotide sequence ID" value="XM_003021509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA3"/>
    <dbReference type="GeneID" id="9578516"/>
    <dbReference type="KEGG" id="tve:TRV_04402"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OrthoDB" id="4171005at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="289" mass="30570" checksum="D702FB1825794035" modified="2010-05-18" version="1">MTSTQDLTQNRLFDVKGFIAVVTGGGSGIGLMATQGLVAGGARVYIVSRRKEVLDDVAKKYSQKGPGEVFGIKADINDPNDIENLAKELEAREPKGINILINNAGVTQEAEKKGHASSVDYHSADSVRSWLEGNGRDVWQQTLASNLISHHFVTARLIPALDKGSSIVPGHSSSIINISSISGTVKSTSAGQYAYAASKAAFTHLSRQLAHTLYPLRIRVNCIEPGLFPSEMTTGGSDENQKSKIEGAGSKFPAGRTGQEADIASAVLYLGSRAGTFVNGETIHVDGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA5</accession>
    <name>D4DBA5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04404</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021557.1">
        <property type="nucleotide sequence ID" value="XM_003021511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA5"/>
    <dbReference type="GeneID" id="9578518"/>
    <dbReference type="KEGG" id="tve:TRV_04404"/>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="199"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="746" mass="83164" checksum="F16F751D2D4CA428" modified="2010-05-18" version="1">MANKKRQTKPVEPPKKRLKTNKSDKSSGTALTEEVTNINALKWQTVQPPDILEDAEGFYGLEEIEGVDIVRPADGEQLKFLAAKSSIKTGDNEELDDDDDGEEWEGFSDEVEQQPEPEQSSFKSTENKKKKDKKEREKPRQEKGNTKVQSIPFSVLNEANDEADVDVSAWDSLDLRPELQTSLSRFKFAQPTPIQKATIPEILGGRDVIGKAATGSGKTLAFGLPILQYLLNRQEQRPSTSLTLSKSGDKKPVALILSPTRELAHQLVKHLKEVTSSAPNVDAYIASVTGGLSVHKQQRQLAEADIIVGTPGRLWDMVSSTPQILTKLRSIKFLVVDEADRLLSEGHFKEVGELLSALDKTRTSDEDVDEAPEEEEELGGRQTLVFSATFQKGLQQKLAKRDHSFHDNLLDKKESMEYLLKKLRFKDEKPRFIDVNPVSQMADNLKEGIIECSAMEKDLYLYSVLLFYPKHRTLVFTNSISSVRRLTHFLQNLNLPALSLHSSMAQKARLRAVERFSSPTADPSPILIATDVAARGLDMQGIDLVIHYHVPRTADTYIHRSGRTARASASGKSILICAPEETAGVTRLVAKVHHTQKRKSSSKDVQLHSIHLDRGIVTRLRPRANLSKKITESTLAKEKISSEADWLRSAAEDLGVDYDSEEFAEQESKSRGRGRGGGRQAKERQASNVSKAEMARLRAELRDLLSKRVNLGVSERYLTSGRVDIDALLKSEGNPAFLGHVEKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBR7</accession>
    <name>D4DBR7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021321.1">
        <property type="nucleotide sequence ID" value="XM_003021275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBR7"/>
    <dbReference type="GeneID" id="9578165"/>
    <dbReference type="KEGG" id="tve:TRV_04565"/>
    <dbReference type="HOGENOM" id="CLU_022275_0_0_1"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53495" checksum="2B3217C3009F1C3D" modified="2010-05-18" version="1">MERVCVASKQVCRSSLVDGLLACLMLCMSFSLPKREKNPLLSVQAFHDFNLLGQSVLGAGWTQAAAVQRTEDRERKRERGSVWHVSVYVHHGTLRLTASAECVCKRPNTRSPTPAAASGNRDSKTSSLPFHPARDLIASPKDSSHIQVTQNFSFLRQPEIFHPLSQLEIPLPFRSEFPSLLPGQPLESALQQLDDLCKKGHYLPAAHFAATILTSSLITSTDYSAIFSLLYTRLTCLLLTGNTLLAAEESKALQDLNSSFYYVDVKPDLPKEDGSSQEPPERAHLAPWPLRVIAVRLQSIGFSDTRRGISGLYDLGLEARRHIIRPDVGAEEKALWKARLGDLGIRVVNALVEMGDLEAARRSLATNIVEPLLKMAEGKFDEAVTGWNDLLKTYSGTDDEVLIKQNLAVCLLYVGDLKQSREILESLVDDHNSFQSLTFNLATVYELCSENSGALKAALAERVAEHPQSEHRNWEIPNGAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC29</accession>
    <name>D4DC29_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021249.1">
        <property type="nucleotide sequence ID" value="XM_003021203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC29"/>
    <dbReference type="GeneID" id="9578094"/>
    <dbReference type="KEGG" id="tve:TRV_04681"/>
    <dbReference type="HOGENOM" id="CLU_036616_0_0_1"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="183"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="556" mass="63276" checksum="AC6824246357225F" modified="2010-05-18" version="1">MEGMNGNHIMAEDNIINRRGGESLFQNCSNLKKRLAEVPGFEPHLAEMQELDKASDENDPVASVWKCLRQGYPLMTIYNATHPSEPLSIDENKLQERNRPKAATFKFLQACLQVLKFPQQECFLITDLYGDSTTGFVKVHLPPLFLTSRTVVIDILELQGQLYNKVSPSTSLPSEGGKTKLTRREHILKEMLETERDYVHHLQNLQALKKELEETGALTGDVSHQIFLNLNNLLDFTQRFLIRMEQHNALPEETQNWGELYLSHHNGFLQYEPFIANQPRCDQICQREWDKIHSAPRSPDLQQMVAQLSTLNGFFVKPFQRLTKYPLMLMELRKQTENPGLVSDIGEAINMIQIILDNANRAIDKEHLVSAVEDLSQRVEDWKALKLDQFGDLLRYGTFTILKGDSGKDAEREVRKILSNTTAQSYLLGSRRSSFTGSVIHLLSANSHRGWSWKQSKDPKYISVFPTPTQVAHPLELLTPTHSASTKTLEFNTPPPRPRQDSFDTSPSKSRRSISSIFSFPKSKHRSSPITPSIPQQRLNKAHVRKNSGVGSEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC32</accession>
    <name>D4DC32_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021252.1">
        <property type="nucleotide sequence ID" value="XM_003021206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC32"/>
    <dbReference type="GeneID" id="9578097"/>
    <dbReference type="KEGG" id="tve:TRV_04684"/>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="69"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="582"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="805" mass="90746" checksum="C5FC34ECC13919B1" modified="2010-05-18" version="1">MNTTSIRSSEYSYRDPRYYSSSSLGNAPLPKTLDGYGGMMHPDDGEGSRYNPQLSRGSVLLNPNDPVSMHLLAETAIGDSLHFEVLSFEEVEELKRELALVQSRIDGGKRKLALELKLQEAAQSLNRLYDDGSDRVNGHLGQDAHRHGHGHGDLDTSDEGLAITRRKCEEQAQEIAKLERRASDIRTRILEHTAGVLQMTHKGLKKKKGSKTDDLSSTSDDLNGLDPYGCGHEFDHRSLYRTADYLDHHGGAPPRDVPSLEPDVESLSGLQDTQSKLEEMTYRLREMLTQMNTDQEIDPIPQIITNEGSSDPLATVNIQIDYLEKGLETIALHQSHSSRGQDSHTSEDSPSNHDTIDRLDAFSRRLDEALAAAGSSRQPTSPHMSTIRKSMAEQLDYLDSAVTDVEKRIDSLVEQKTILGIQIQQQRDLNSKSDAERDAYIADLTEDLTKLRKELDKSQAEEESSKAEIAMLIDQLDAARQDSMLREQKRSIGEAPEATPEKEALMKAGQELAEKETQISNLESTIQELRSQTDAHLHHTREQVQQDLAEKDSLISNLESTLQELRSQADSQFSQIKEAHQSREEAEQAHAKLQTEFSELESDMVRIQTELTFAKAELDSAYGSRSERAAEAAANPAVQREIDSLRERNMDLTSQIATLKSVQMNNANSASMGAHERIQVLERELRETIEDYEELTKQSIEFEKERDKLENMIDTYRDRCDTLETQLGDERIQNLGIRDGMTVENTSITVLKSEFKKMMRETRADSIKALRAEQEERRRLESMLRAMKREQSLKKSNLSQSTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCJ7</accession>
    <name>D4DCJ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020987.1">
        <property type="nucleotide sequence ID" value="XM_003020941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCJ7"/>
    <dbReference type="GeneID" id="9577839"/>
    <dbReference type="KEGG" id="tve:TRV_04852"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="254" mass="27556" checksum="FD10032E6FB97610" modified="2010-05-18" version="1">MGRVIRNQRKGRGSIFTARTRLNKAPAQFRTLDYAERHGYIRGVVKKIVHDSGRGAPLAQVSFRHPYKYKEVTETFIANEGMYTGQFVYSGKHASLNIGNVLPLGSVPEGTVVTNVEEKVGDRGALGRTSGNYVTVIGHNPEEGKTRIKMPSGAKKVVSSRVRGMVGIVAGGGRTDKPLLKASRAKHKFAAKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAVQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY1</accession>
    <name>D4DCY1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020911.1">
        <property type="nucleotide sequence ID" value="XM_003020865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY1"/>
    <dbReference type="GeneID" id="9577732"/>
    <dbReference type="KEGG" id="tve:TRV_04987"/>
    <dbReference type="HOGENOM" id="CLU_035821_0_0_1"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="390" mass="41053" checksum="06FD16D747E0735D" modified="2010-05-18" version="1">MKIKNSASVKNMNSRREEMEDFNRLPLELELLLAIRFSASIPDIFLDIPDPNSTTVAGLKRLVRDRLPPDLTSRRLRLIHAGKSLDDSTSLATQIKVGRNSHLRGHHGNGQRAPSSGSPSEPGSRVASPFLKGGYATSGSSSTVSQTAPDPSGKGKAPVRDQGEPRIYIHCSIGDITLTPAELDAEARAARSGQDALKSNTSANDSAGSAGLDSSAGPSRPLDGGDASTAGGDGSNITPTPAPQGFDRLLSAGFTPAEVSSLRSQFLALLSLSHTPDTLPSGTELRRLEDRWMDEGSTEAGVAGLGGNNEDSNIFGDMNTDSTGGSGPFGSGTSRALDDMLWGSVMGFFWPVGCALWLLREEGVWSWRKGLAVFVGVVVNFGFGAVRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD49</accession>
    <name>D4DD49_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020830.1">
        <property type="nucleotide sequence ID" value="XM_003020784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD49"/>
    <dbReference type="GeneID" id="9577601"/>
    <dbReference type="KEGG" id="tve:TRV_05056"/>
    <dbReference type="HOGENOM" id="CLU_092690_0_0_1"/>
    <dbReference type="OrthoDB" id="14384at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052716">
        <property type="entry name" value="MOSC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36930">
        <property type="entry name" value="METAL-SULFUR CLUSTER BIOSYNTHESIS PROTEINS YUAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36930:SF1">
        <property type="entry name" value="MOSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="180" mass="19492" checksum="4C596DE986A674CA" modified="2010-05-18" version="1">MSVLSVSASGSHDFSKSTVPNITLVENVGVKGDAHSGAHVQHLSRLHINPPPQNLRQVHLMPYEVLKAVSVNPGQLGENITTEGIDLLALSKGTKLRFVDQKSPTVDCPVVTVTGLRNPCPQIDKFRSGLKEHFIVRDANRTIIERKAGIMGVVEAGGDIRPGMTIVVEQPAVFERMECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD80</accession>
    <name>D4DD80_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020811.1">
        <property type="nucleotide sequence ID" value="XM_003020765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD80"/>
    <dbReference type="GeneID" id="9577562"/>
    <dbReference type="KEGG" id="tve:TRV_05087"/>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="96"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="298" mass="33058" checksum="3A125C37939A148D" modified="2010-05-18" version="1">MANRGYDAVVNVDAEGDLGHTDLQEDLEFHSSNFDETPRNAKGHPDSSSFLAGSSSRQGGGSGGAGSNAKIWSIAYYNRYFDVDTSEVFRRCVSTLYPRSNFLDVLDGNPDLYGPFWIATTVVVILFLTGTVSQYLARKGSHHFEYDFRLLSGAAGLIYGYTFILPVALWGALRWFGSSSADLIECWALYGYANLIWIVVALVSWSPLTALNWALVGVGFGWTVFFLLRNLYPVLSATDMKTSKILLIVVIVLHAALAIAIKVLFFAHGSYAKKHDDDHDDKHDKGNKHDDKDKHSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD84</accession>
    <name>D4DD84_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020815.1">
        <property type="nucleotide sequence ID" value="XM_003020769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD84"/>
    <dbReference type="GeneID" id="9577566"/>
    <dbReference type="KEGG" id="tve:TRV_05091"/>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="452"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="205"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116126" checksum="71549A2FD46E31DE" modified="2010-05-18" version="1">MAPKKKSNKKADDDWEAELGESIAPANQTEKKEEPQADAAAPEEDDDLGGGLLAALRKNKNKKAKKGKPTNDFVEGEDPVSTIESKQPEEGTFDDDDVFAGKPKPAKGAAKKEAAKPAEPEEGGKLKSKKEKEREKKEREKQRKKEQAAKKKASAPAAAAQAAKPEATKPTPAAETKPAPAPAAEPAGKKKKIPAHLAAIQRQQEALRKQQEEEARRLELEKTLAEEERKKLEEEERRKEEIRQRKKEKEREKKEQLRREGKLLTKAQKEARDRNELRMKQLLEAGGAVVAGLEEKPTEKKKPVYENKKKRGGKKQEEDLEAAAARAKAQHEAEEAERKRLEEEKKAKEAAEAAKKAEESDDDIKESWDVSSDEEDEAKPEAKEEAPKAAGKEEPEAGTPEESESEEESEEESEEEDVTSTQKALAQRKAEAAERRRKQHEEAVAAQSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDALVQKTAVVNKDGKFDFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMRLLRDRKTPFIVALNKIDRLFGWKKIDNNGFQDSLAKQSKTVQSEFKDRVAKTKLAFAEQGFNSELYYENKSMARNVSLVPTSAHTGEGVPDMLKLLVTLTQERMTNALMYLSEVECTVLEVKVIEGLGTTIDVVLSNGVLREGDRIVLCGLNGAIVTNIRALLTPAPMKELRLKSAYVHNKEVKAALGVKIAANDLEHAIAGSRLLVVNHDDDEEDLTDEVMSDLENLLSKVSRDNRGVAVQASTLGSLEALLEFLRTSKIPVANISIGPVYKRDVMRAGAMLEKAKQYAVMLCFDVKVDKEAQAYADENGIKIFTADIIYHLFDDFTKHMEELAAQRKEESKLQAVFPCVLSPVAVFNKKDPIVIGVDVTEGSLRLLTPIAAVKTNPTTGQKEVISLGRVMSIERDHKQLPICKKGQPSVAIKIEGPNQPLYGRQLEEKDTLYSMISRKSIDTLKEFYRSDVTMEEWALIKKLKPVFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDH4</accession>
    <name>D4DDH4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020734.1">
        <property type="nucleotide sequence ID" value="XM_003020688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDH4"/>
    <dbReference type="GeneID" id="9577433"/>
    <dbReference type="KEGG" id="tve:TRV_05185"/>
    <dbReference type="HOGENOM" id="CLU_106785_1_0_1"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20713" checksum="9404C89E52F60B2A" modified="2010-05-18" version="1">MTKNLNKITKKLSKKKGKLDSLHEKSRDAVRLRRAGGREEKLARAAATTMKGRQIYVDRVAFFRDHTKDLEAPLTSEGAVSLLRQYLDRLKPELQEEQEARRKGRPPSKRQEVLTEKIEAEEKEYQTGFWMPDLECEDSLRRLRNWNEDWSAMSNLKFVRLSKAGDKRPSLFPPKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY0</accession>
    <name>D4DDY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P-Pant transferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020557.1">
        <property type="nucleotide sequence ID" value="XM_003020511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY0"/>
    <dbReference type="GeneID" id="9577255"/>
    <dbReference type="KEGG" id="tve:TRV_05344"/>
    <dbReference type="HOGENOM" id="CLU_031126_1_1_1"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000023">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="5">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="319" mass="35937" checksum="D117F786D00F2203" modified="2010-05-18" version="1">MASDSRLTRWYIDMSRWTESTTLLPLIDTLQPAEQKKVRAFYHVADRHMSLASCLLKYLYIHRSAKVPWNQVIISRTPNPHCRPCYINTRETETLRLEFNVSHQASMVALAGYMYHSDAKADSMRKLDPSSSGAKGLPQVGVDITCTDERERRNPSLAPSTDKDLCEFVDIFTEAFSTRELEIIKAGGEDGQARSVKHRTRMFYTYWALKEAYIKMIGEGLLASWLQKLEFTNVVPPEPEEEGVWGKPLSGIEIRLKGEPVDGVRMEVVAFGQRYILATAMRGGCVGQAQGSDAWDEFTAIDIDKEVGPCARGECKCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ7</accession>
    <name>D4DDZ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020532.1">
        <property type="nucleotide sequence ID" value="XM_003020486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ7"/>
    <dbReference type="GeneID" id="9584272"/>
    <dbReference type="KEGG" id="tve:TRV_05361"/>
    <dbReference type="HOGENOM" id="CLU_023205_7_0_1"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000037">
        <property type="entry name" value="L-galactose dehydrogenase (L-GalDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="384" mass="42104" checksum="D88A88574A52A922" modified="2010-05-18" version="1">MGTATFNGQYNANPYELPTTELVHRALSAGICAFDTSPYYGPAEELLGRALSTQFVRENYPRSSYRLLTKVGRIAASTFDYSPAWIRRSIKRSLSRLGTAYLDVVYCHDVEFVTPEEVLGAVQELRRIRDSEGTIHYVGISGYPVDVLCSLAEMILEKTGEPIDIVMSYANFTLQNTLLATKGLERLIAAGVDCVLNASPLGMGLLRRNGVPIGSMGDFHPAPNELREAIHKASLWTEEQGEKIEVVAIRYALENWLHVGAAVGASGLPSGDQTNGTSTNSTTSPRRLGGSVMGVSNIAELEETMRVWKVILDSLSSESINPQCRKGHVVLNKDQKLPESQRIQTLTKGVRDILGAKWVDFAWASPDADYVNTPIPEHPPPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE90</accession>
    <name>D4DE90_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4291 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000287">
        <property type="protein sequence ID" value="EFE39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020456.1">
        <property type="nucleotide sequence ID" value="XM_003020410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE90"/>
    <dbReference type="GeneID" id="9584195"/>
    <dbReference type="KEGG" id="tve:TRV_05457"/>
    <dbReference type="HOGENOM" id="CLU_082565_1_1_1"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23878" checksum="F5E98B6EDBA058CC" modified="2010-05-18" version="1">MTDSNPYRAIRAKFTENTITIYQAYSNEIADAALGAGTFVAPFKRGRMTWIKPSFLWVAYRSGWATKPNQERVLAIEITRSGFEWALRNACLSHVDNSLYKDKSAWESRMQASCVRVQWDPERDFHFNPLGYRSIQIGLKGDAVDRYVDEWIVSITDITEQIRKVSGLVSSGQLGEAKKQMPEECLYDLPDDVGEMIGASTAVKEPASHQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF80</accession>
    <name>D4DF80_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020053.1">
        <property type="nucleotide sequence ID" value="XM_003020007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF80"/>
    <dbReference type="GeneID" id="9583817"/>
    <dbReference type="KEGG" id="tve:TRV_05826"/>
    <dbReference type="HOGENOM" id="CLU_034311_2_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="38770" checksum="78BB48A940ACBCA3" modified="2010-05-18" version="1">MQARGQETIVVIGAGVLGLSSALELIEKPETSKYQIVLVADHFSTDPPNPVYATTNAGAHFRPIPATDTQTELESDHAVRTYSRFKKLAEEEPAFGIKFLEGIEYVSGPAAEKYKAMKPNYVKQEGFRLLEGPEKPAGVDFAARYESFIVEPDTYCFHLLRRFRLKGGKILRLRLQSVEEAFCLDGYKVSLVVNCSGMGFGDPKTFIIRGQTCLIAETATKTVTQQNADGTWTFLVPRPLNGGTVVGGTKEVGDWNPTASIAVREELLRNAAKMYPGIVNSKGGFDVIKDIVGRRPAREGGMRLEVETLPDNRPVVHAYGIGGRGFETSWGIAEDVQRMVTETLGKRPLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFC8</accession>
    <name>D4DFC8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">TRV_05874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020101.1">
        <property type="nucleotide sequence ID" value="XM_003020055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFC8"/>
    <dbReference type="GeneID" id="9583865"/>
    <dbReference type="KEGG" id="tve:TRV_05874"/>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="260"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="56128" checksum="BFE0B28685E60998" modified="2010-05-18" version="1">MADNAPTSASTLLKDAAAQSAATADEVAKKHDLLPKLIPYLDRQLIFPLLEFASNQEEDEEAIDQITKSKYELLKHTNMADYIASLWQEINDSDTVPEEFVTKREEVVQKLQHYVDASSKITELLQDDAVVGNLRSDKAANLKFLEEQHGATIEMVNTLYDFGRFQYSCGSYGNAAELLYQFRVLSTDNDKVAAATWGKLACEILTTNWEGAMEEITKVKDSIDTRLFNNPLGQLQHRSWLIHWSLFPFFNHEPARDVLTDMFFHPAYINTIQTACPWILRYLTAAVITNRSRAHKNSALYQKQLKDLIRVVRQEEYEYQDPITEFIKALYIDFDFEEAQKKLGEAEEVLRSDFFLVAAADAFVESARHLISESYCKIHQRIDINDLSTRLGLSQNEGEKWIVNLIRDTRVDAKIDYQEGTVLMNHPPQSVYQQVIEKTKGGFFRTQVLRRDLVASFFTQVNVYDERRNDPKAHLLFRPDADTLTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN6</accession>
    <name>D4DFN6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020018.1">
        <property type="nucleotide sequence ID" value="XM_003019972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN6"/>
    <dbReference type="GeneID" id="9580187"/>
    <dbReference type="KEGG" id="tve:TRV_05987"/>
    <dbReference type="HOGENOM" id="CLU_019358_1_0_1"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="1">
        <location>
            <begin position="316"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="491" mass="54610" checksum="534AB2EB16404946" modified="2010-05-18" version="1">MTLDKNGQRCFGLLSFLKKAVQHSRASPSAAKIPRTYVLGNTSADLDSIISAIIYSYFASSATSERGIQYIPVINLPEVPAGRELRRLRPEFVTALNLATQRPLKTAQNAASKDLKTLPDDEDTDNILSESILTVASLRDELVNWKPSDDKKAISLNIIMVDWNALPKTSPHAYGIPGVSDKVDGIVTSVVGCIDHHDDEGFISKHLVPGPGTRVSHIQTGVGSCTSLVVCELRKLGWWRDVAGDNKTISEGQSLSNSDAEFESQAAQLALAAILADTTNMTNESKVFDVDREAVRFLENKINQCKSINWDRGRFYDLITDAKSSSVDYLTAHETLGRDYKEWTDTVEPGRNIKIGICSVVKPVSWILKKCGSEYSEEEYDEEAFFDVLRSFSSTRGLDVVAVMTAFSSPSENEFQRELVVTVLNDRYISNLGEFEDAGADYLRLEKRPFNEKNKDLGQIGRNTRVWRQLDVTKSRKQVAPLLRRVFAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFP3</accession>
    <name>D4DFP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome c oxidase subunit V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05994</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019948.1">
        <property type="nucleotide sequence ID" value="XM_003019902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFP3"/>
    <dbReference type="GeneID" id="9584700"/>
    <dbReference type="KEGG" id="tve:TRV_05994"/>
    <dbReference type="HOGENOM" id="CLU_070101_1_0_1"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23636" checksum="33B3A85D70F4B078" modified="2010-05-18" version="1">MSFRATPRAVAGTVRSATCSNFAARSNQASPIACLNARVPVSSQLASPSKQQIRSASSEHAIANPHLAGIEKRWEAMPPQEQAELWMKLRDRMKVDWKEMTLQEKRADGLFIPLKCAKGINYSYWIAFGPHGPRAETPKGEGVKIFVQLMKYVVISAGIFYATRLFAGSPPKTMTKEWQEATNEYALKEKLDPITGISSEGYSGKGFVQSAPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ3</accession>
    <name>D4DFQ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019958.1">
        <property type="nucleotide sequence ID" value="XM_003019912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ3"/>
    <dbReference type="GeneID" id="9584710"/>
    <dbReference type="KEGG" id="tve:TRV_06004"/>
    <dbReference type="HOGENOM" id="CLU_066899_0_0_1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="372" mass="43181" checksum="0BA37AE2F784AA51" modified="2010-05-18" version="1">MLPYLFPTGLLLQIFQSCTSIADILNLALTCRRFHQIFASSQKLPLLASAAEAEYGPLKDIIQLVTQNSSQPAHAIREAPLSINLLQQIVAVGRVARKWEEIYPVKKWKVDFQDRRLLTDHERYTLRRAIYRLWLYSRAFHCALYPRGSRAVPAVVRERAELLHNWSTDELAEMEDTRLVIREVVQNHICPSNGTIQRKFHKRFPENTQSLSFNIHLNYPPSHGSSDFYFADPYRSHTPPLHDQETFFLNPSKNDRSGTSQFSTSTNKYATKFRSDLYHDPGAEGWGDEIPHYYVVEDMLKLDPGQVIWLRENTRLKEQVERYVKSIGDWFENNGETFGQTLEWVLNERGEDIEAFKDAIFDQELGIAKSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ8</accession>
    <name>D4DFQ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_06009</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019908.1">
        <property type="nucleotide sequence ID" value="XM_003019862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ8"/>
    <dbReference type="GeneID" id="9584659"/>
    <dbReference type="KEGG" id="tve:TRV_06009"/>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF48">
        <property type="entry name" value="STEROL REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE39284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="527" mass="59792" checksum="9329BCD788023C66" modified="2010-05-18" version="1">MSSPRKRATAKKAEELREEVEEHVSTANGSNGAANGAVNGAAANGHSEKKAEAEQTTEDHKITDHIEFGGTPGVTAMMIGFPALMYYMWIGATYYDGAFPTPSEGQSMSDFLQHLLNLVYTGAFPSLKAWTIYWGFFIFEALAYMYLPGITVKGRPLDHLGGKQLTYYCSAVSSFYTTIVLAVILHVTGVFKLYTIMDEFGPIMSVAIITGFVISIIAYFSAIARGAQHRVTGYPIYDFFMGAELNPRLFGILDFKMFFEVRLPWYILLLLSMGAAARQYELYGYVSGEVGFILMAHFLYANACSKGEELIIPTWDIYYEKWGFMLIFWNLAGVPLSYCHCTVFLANRHPSTYAWNKYALAFLYIAYLFVYWVWDTTNSQKNRFRQESRGLAVIRNTFPQLPWQTVKNPKTITSKKGDTILADGWFLLTLVSDGYARKIHYTCDLYFAINWGLITGFTSPFPWFYPVFFAAMITHRATRDIQRCRAKYGEAWTEYEKQVPYLFIPVSPPTASFMTGLHQTNLLYSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV0</accession>
    <name>D4DFV0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019855.1">
        <property type="nucleotide sequence ID" value="XM_003019809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV0"/>
    <dbReference type="GeneID" id="9584606"/>
    <dbReference type="KEGG" id="tve:TRV_06053"/>
    <dbReference type="HOGENOM" id="CLU_005533_12_2_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="233"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="405" mass="44704" checksum="8401759AC80B1EBE" modified="2010-05-18" version="1">MLQSLTTIEAALRTVLREFDQPDNAALLASLRRVDQGGDIRVTSAANNIIDLANKVIQTLEPAHLALADHLFEYQNTQCLAGAVKLRIADHLSDGSLKLEQLATASKARPDRLRQILRLLANNGIFHYDSATDTVRNNEASEMLQQSHWTQWQRWASVCGHEFYEMARGLPQSLDEEAARSPAQIHYDTDESMFSFLESNGTMVRLRECMGATAMAQTPGMVSAYPWGELAGTTLIDLGGGDGSLIAALLRAFPDIRGGVFDTPRVLPFLQEAFHSPAGKYADVGSRISSENLIAGDFLTEVVPAEAYVMRWCLHDWNDEQARKILENIRKSIIKGPVSRLVVLESVLADGDINVMVTAEHGQERTESDWRRLASSSGWEIARIAPLPGAWPSAIDLRPGTICQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ7</accession>
    <name>D4DFZ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019811.1">
        <property type="nucleotide sequence ID" value="XM_003019765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFZ7"/>
    <dbReference type="GeneID" id="9584562"/>
    <dbReference type="KEGG" id="tve:TRV_06099"/>
    <dbReference type="HOGENOM" id="CLU_2147692_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="12629" checksum="02C77FF175E49FD3" modified="2010-05-18" version="1">MAAIAYGCYWHSIKTGWQSIPFNTLSCIRLDLSLYLLSFFHLQAASLLLSWSHLLLIFIFPRHVTRMSLLSILGKEKKKMMMARALSCPLLVFSSASLSSSSPVMPFVNFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG02</accession>
    <name>D4DG02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06104</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019816.1">
        <property type="nucleotide sequence ID" value="XM_003019770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG02"/>
    <dbReference type="GeneID" id="9584567"/>
    <dbReference type="KEGG" id="tve:TRV_06104"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_0_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="445" mass="50471" checksum="4351A8FA157E6848" modified="2010-05-18" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAVYLNYTRSLRFDDKPDYSYLRKIFRDLFVRESFQYDYVFDWTVYKYQKNAQAIAQATGNAGNGQEEDERPRRIANANVASGNPAIQNKPTVMAPRRKVMDRGAYENPDANRAIGGSDRIGPFDEDAWAGLHGEGQSLFLLVFSIENLTNVIVFGARLRSASKGGSNLMGIGGYHSSPYHRSSKRDDGNNGTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG13</accession>
    <name>D4DG13_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019827.1">
        <property type="nucleotide sequence ID" value="XM_003019781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG13"/>
    <dbReference type="GeneID" id="9584578"/>
    <dbReference type="KEGG" id="tve:TRV_06115"/>
    <dbReference type="HOGENOM" id="CLU_094297_2_0_1"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="17548" checksum="E3BD3A32788E2D28" modified="2010-05-18" version="1">MPERSSMLAPAHILRTLPRPQFSTLQSSIFPVYFGLQTAVPLVLALTYPGEKVAGRFGTSGLSGVSSESNRWNTLVPIMTTFLGGITNLLVIQPATAKVMRQRKEQESIDGKKYTDAGPHSKEMMKLNKSFGKLHQLSAVVNLAALAATIYYGVVLAERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGG4</accession>
    <name>D4DGG4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000356">
        <property type="protein sequence ID" value="EFE39052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019697.1">
        <property type="nucleotide sequence ID" value="XM_003019651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGG4"/>
    <dbReference type="GeneID" id="9583604"/>
    <dbReference type="KEGG" id="tve:TRV_06268"/>
    <dbReference type="HOGENOM" id="CLU_2711832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="73" mass="8629" checksum="ED9DBF215122E8F5" modified="2010-05-18" version="1" fragment="single">LQSLLKKRKKKAPAVLHQYLANPSLAALTTLYVPRVECFVTNCIRSTLLFYIGCSRFHFRRQKETKIFPCWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGN6</accession>
    <name>D4DGN6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline-sulfatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019623.1">
        <property type="nucleotide sequence ID" value="XM_003019577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGN6"/>
    <dbReference type="GeneID" id="9580153"/>
    <dbReference type="KEGG" id="tve:TRV_06341"/>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="528"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="66077" checksum="216157FC06EB9F1D" modified="2010-05-18" version="1">MAQSKKPNVLYIMADQMAAPLLSIYNSSSVIKTPNLDRLAKEGVVFDSAYCNSPLCAPSRFTMVSGQLPSRIGGYDNASDLPADTPTYAHYLRDQGYHTALSGKMHFCGPDQLHGYEERLTSDIYPGDYGWSVNWDEPDVHKDWYHDMSSVMEAGPCVRTNQLDFDDEVIYKAKQYLYDHARHRKDQPFCLTVSMTHPHDPYAMTQEFWDMYEGVDIPLPTTAALDQAKQDPHSRRILKIIGLLGKEIPDERIRAARRAYFAACTYVDTQIGALLATLKNCALDENTIVVFSGDHGDMLGERGMWYKMSWFEMSARVPMLVYAPGRFKPKRVKENVSTMDLLPTFVAMTGGSLYPGLPVDGVSLMPYLADDAPGEKTDTVLGEYMGEGTLAPLVMIRRGAWKFIYSPIDPPQLYNVEQDPTESNNLVANMALPALSDNSSSGGAVTGPAALPTPPTTSPPVLKNPAASAVLSLHAVPTPPDTPMLGKKAVAPTAAEITSATATNDITSLFKAFLQEVHARWDFDRIQQQVLNSQRRRRLVYSALSKGRITSWDHTHIVEGSSVFIRNHGKGALGDVETISRLHVPVSVGREVQYRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH52</accession>
    <name>D4DH52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein required for cell viability Rrp17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000372">
        <property type="protein sequence ID" value="EFE38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019463.1">
        <property type="nucleotide sequence ID" value="XM_003019417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH52"/>
    <dbReference type="GeneID" id="9577913"/>
    <dbReference type="KEGG" id="tve:TRV_06507"/>
    <dbReference type="HOGENOM" id="CLU_067149_1_1_1"/>
    <dbReference type="OrthoDB" id="4174413at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="27917" checksum="89ADEA5FD2802CCE" modified="2010-05-18" version="1">MRPPTKKRKIAAPAQPEEISFNPDSRAEFLTGFHKRKVQRAKKAQEAAERRAKEERRETRKKIRQERKAEFEEALKRHRAEMEALNGFPATGEESGSGSEQGGDDDEEEEWGGIVEPPPVDYEAEYIDEDKYTTVTVEEIEATREGLVPRRELNEKKDDEDEGSGDEEEEEEEDGAKEKDDGMSKKKKIWTKDNPNKDVKKKRKRKRDFKYESPLERKLNRAKERGRKKKQAEARKAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB1</accession>
    <name>D4DHB1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rxt3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019400.1">
        <property type="nucleotide sequence ID" value="XM_003019354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB1"/>
    <dbReference type="GeneID" id="9580116"/>
    <dbReference type="KEGG" id="tve:TRV_06567"/>
    <dbReference type="HOGENOM" id="CLU_025880_0_0_1"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="62555" checksum="B746F430FD383C1E" modified="2010-05-18" version="1">MFSPTPGSTGPQSSFGGSFADEGRARGGTEEPPHHKNVLNINAEAKRGGRASPLPQAVQGAQAQIIDPATESGIKSELGRVFSGIGSGVGVSSSASLGGSGPSTPLSSSPFKRNHGDRPMNSDLNGEGSFGAGKGTASAPGSVRRGRKVKEEETREDGEGIGAAARGGVARRGRHVHHHHHHHGGHQHRADDDPSLFTGGQGPQLAAPFRPQSRTGDGPTVSGAVGASHHHHHHHHHHHGPRATVPGSGIPHHHHPTPPAVPLKEYNTTVNLEPLLRSVAHLPRYHLGSTLYAPRIEMPSSRAPPEASKFGYTSTPVPIPRFDGKENCTFTIRVPRFRIDASHREEICARRALWGTGVYTDDSDPVAAAIHSGFIRGEWAEDVDVSMLNLELKDNRKSSSTTVTANVNGTAANGKTTPSSNRTPSVHSNSTRSDPTSTAQSEAPQPPPTAADSVEGKQLPPIPPPDKDLHIKLLILPTLERYESSVMYGLKSRSWGKNHDGMSFKVEEISWVDEGASKGEERGGEARRKRLRNMMRTGRICTPAGLKGRKGVELHLSSNRDPDTTMKDADEPPTIQTSTSTAVEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHS9</accession>
    <name>D4DHS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019247.1">
        <property type="nucleotide sequence ID" value="XM_003019201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHS9"/>
    <dbReference type="GeneID" id="9577487"/>
    <dbReference type="KEGG" id="tve:TRV_06736"/>
    <dbReference type="HOGENOM" id="CLU_1022968_0_0_1"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="289" mass="32744" checksum="FCEB1D4341F16C71" modified="2010-05-18" version="1">MDVHHHRSSALDKIDKIFWLHKLWRCGNPSLPLFRCGTGEEKRPKGESRDDVYIPSTLVPEQYSEQYTMASQDTLKSAQPLPLEAASIASSSPAEQIAVLDILFEPSQNLHNLALPLLQTPFNSYRELIDRVRAELHQLAERAASDDTDKKILYDILGSHPRLGAPKSSHLSEFSRREQVNLATVTSPGQGVEDEADRLRKLNEEYERTFPGLRYVVFVCGRGRDVIMEDMRRRIDTADVSSEIDTTITEHTSALYGVYKYTITLSLTLTFHSLLSSLPPRVGFSRFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU1</accession>
    <name>D4DHU1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019199.1">
        <property type="nucleotide sequence ID" value="XM_003019153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU1"/>
    <dbReference type="GeneID" id="9577224"/>
    <dbReference type="KEGG" id="tve:TRV_06748"/>
    <dbReference type="HOGENOM" id="CLU_005947_0_1_1"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="772"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="857" mass="95740" checksum="3233195D9DE1A86B" modified="2010-05-18" version="1">MDTVKAAIERWKPSLETRERLWAIKRKTPVLKDLHYNFICLHYAWIIGVTLVGSIILYPGGNMSYVDALFFASGSATQSGLNTIDVNKLYTYQQVWLWMGSMIANPIVIHSAVVFVRLYWFEQRFQHVVREAKALRRSRSRSRAPTREPDDNNDLHRAEAGVRGRDIVVLRNTDGHAQGRFLDAPKKEPETTSESDSSIQPAEGQGETTAANGTGQSTSNTSSKTNETLLEPSHFPGDARIQWSVPPSDNERHITFLEHQRRQTGALRIPSPREYDRGGMPEALDETDGADLARNATVQSDPPAELAGTSLPTSPGPINQHITIDEPNITRTRKATHSRGGERDRDRDGDETSTIRRVTSRRSMVPSFMRSRTLEQLQQDAPYLSWEPTIGRNSAFVDLSETQREELGGIEYRALKTLAIVLIGYFFFFHLLGIVCLIPWILNTHWGEIVRAAGQGRPWWAVFSAGSAFNDQGFTITPDSMLSFYDAVFPMLLMTFLILIGNTGFPCMLRFVIWFFSMIVPKGSGVWEELKFLLDHPRRCFTLLFPSSANWWLFWVLVLLNGVDLIFFVVLDLNDPDVTRIPGGIRFVDGLFQAAATRTAGLSVIGLTTLHPAIQVSYMIMMYISVFPIAISVRRTNVYEERSLGIYSDPDEYSENEKEPSFVGAHLQRQLSFDIWYIFLGLFVISIIEGTRLDNPKDLGFSLFAVLFEVVSAYGTVGLSLGYPDSNTSFSAQFHTLSKLVIIAMEIRGRHRGLPYALDRAVLLPSESLHRKEEDDASKRLRRRSSNVSAFSSATGQASGLFRDDGGLMARLQQQQQQQQQPSSSGGGGVGSSSDAPPPTASSARGAKRLSTHQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI52</accession>
    <name>D4DI52_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_06860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000395">
        <property type="protein sequence ID" value="EFE38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019121.1">
        <property type="nucleotide sequence ID" value="XM_003019075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI52"/>
    <dbReference type="GeneID" id="9582604"/>
    <dbReference type="KEGG" id="tve:TRV_06860"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="223"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="521" mass="58803" checksum="5F175B18AA3AA4C2" modified="2010-05-18" version="1">MASDLTSQVLDVLASTDEPQLSNHVFPTAPAQSVKAALDRLAARDMVLQETIESEEVYLLPEAEGIVANGSHEARVFEAVSAAMEGLKIADLPDIVGKEIAKVGTGNAFKKGWIKKDKDTLKAATDSIEDTSREQLVTIQKTKTHPDAKVLAELRKRKLINTQKVFVYKFWKGPKYAREFVKEETDLTVDMLADGSWKTAKLKGYNFKAKGAITPSGALHPLNKVRHEFRQIFFEMGFQEMPTNRYVESGFWNFDALFVPQQHPARDLQDTFYISDPVQADKPRADPEGDIHLSSLNQAHRYASSKTTLKPLDYEKYWQNVHAAHETGFNGSIGYRYPWSADESLRLVLRTHTTSVSAYMLQKLAQNPRPARYFSIDKVFRNETLDATHLAEFQQIEGVIADFGLSLGGLIGFMEVFFAKMGIHGLRFKPAYNPYTEPSMEIFGYHPTLKKWVEIGNSGMFRPEMLEPMGIPSDMQVYGWGLSLERPTMIKYGVNNIRDLVGHKVNLNFVESNPAVRLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI63</accession>
    <name>D4DI63_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06871</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019092.1">
        <property type="nucleotide sequence ID" value="XM_003019046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI63"/>
    <dbReference type="GeneID" id="9582578"/>
    <dbReference type="KEGG" id="tve:TRV_06871"/>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="176" mass="19568" checksum="9265431A5FFB7568" modified="2010-05-18" version="1">MCATCSIWALSVIDSLVEDEKRREQQKQEDLLKEMDKANKPARLPGDASKGAGLFKTRCASCHTLEDGGANKVGPNLYGLFGRKSGQVEGFSYTDANKQKGVTWDQDTLFEYLENPKKYIPGTKMAFGGLKKAKDRNDLITTASSKRTPNKHFNPTTLHDTPTHLYHLTLPYTISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIC6</accession>
    <name>D4DIC6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_06934</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019033.1">
        <property type="nucleotide sequence ID" value="XM_003018987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582441"/>
    <dbReference type="KEGG" id="tve:TRV_06934"/>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt6 acidic N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-turn-helix DNA-binding" evidence="15">
        <location>
            <begin position="286"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Tex-like central region" evidence="17">
        <location>
            <begin position="511"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription elongation factor Spt6 helix-hairpin-helix motif" evidence="14">
        <location>
            <begin position="867"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6-like S1/OB" evidence="16">
        <location>
            <begin position="1080"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6 SH2" evidence="13">
        <location>
            <begin position="1183"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1406" mass="162099" checksum="65B16EF2708452F8" modified="2010-05-18" version="1">MSTHDLLQTEAVLDEEEDESFGEEGGQSKDVEENGHYDDSSEEELDDEDEDAVRAVREGFIVDEEEEDEERTARRREKKKRRRQERIEEEELLDEDDLYLIRENNPDFELPMHNESKFKRLKRGHKVGRDQPQGINDIFNSDEEDEVETYGRGRDRRNMHDDLDDFIEKDVFSDEDERQQEDEEIARPARKGLSGFAVTEATGLDEAALEDMRMAFGDGNDYLFALEMEDEEEEQEEDEEKQLDLKDVFEPSQLAEKMMTDEDNIIRSTDEPERYQLARKPYQHVTLTEEQFREEAVWISNLMLLKKRLDSDLHEPFQRAVAKVLEFMVTDDWEVPFIFQHRKDYLIHAVKIPIPDGGTNPDGGKYIVEAEKLLSMIDLWDIFEYDLKFRALIDKRNTLQTTYDNLQTISNVKDEMFEEMLPAAITMEELQDVQDYLYFQYSIELKDMALATANHEGENGTAAQRRKASTKTFFERVRNSRAYGLVRAFGITPDAFAQNVMETGRRQYIDDASEKPTDMADNLLDSSFSNGAHAMKAARTMFAEELTMSPRVRKVMRQAFYMSGVIECYRTEKGLKKIDEHHPYYEFKYLRDQQISDIARRPELFLRMLKAEEEGLVDIKVHFKDFDNFKKRLYPEIQSDNSSEVADAWNKERKDVLDLALSKLEKIMSKGVKENIRSECENHVARECREVFSTRLDQAPYKPKGMILGTIPRVLALTNGSGIVGKDPIYWTWVEEDGRVLEHGKFVDLTLGDPDRMIADGKDVEAFVELVERRKPDVIGVSGQSPETRKLYKQLSELVQAKDLRGAFYTDERDEEVSDILEVVIVNDEVARLYQTSRRAEVDHPGFSLQSRYCVSLAKYLQNPMKEPGQQLIPQDKLLKQLETALVDMVNLVGVDINEAVSDVSTANLLTYVSGLGPRKASQLLKVINMNGGVVNSRMELLGVNAQYPAMGVKVWNNCASFLYIDYDNADPDTDYLDNTRVHPEDYDIGRKIAADALELDEEDIKAETDENGQGAIVRKLIKEDAQDKVNDLLLEEYAEQLENNLNQRKRATLETIRAELQQPYEELRKQFVFLGTDAIFTMFTGETAESLAQGMVVPITIKRVSDDHIDGKLDCGIDALVPESEMTDRYDIPVRSLYAPHQTTLAKITYLNRKSFVANVSLREDQVNKPYRRQLDHMRGEWDEDQEREDQEAMKEKTQTDQRALRVIKHPLFRPFNGRQAEEFLAPQSRGDVVIRPSSKGHDHLAVTWKVADGVYQHIDVLELDKDNEFTVGRILKIGGKYSYTDLDELIVNHVKAMARKVDDMTVHEKYQSGTKEATEGWLTTYTTANPKRSAYAFCLDTKHPGYFHLCFKAGLKAPLNSWPVKVIPQGYELQRTPYPDMRALCNGFKLLHANMLAAQQRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJL4</accession>
    <name>D4DJL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018622.1">
        <property type="nucleotide sequence ID" value="XM_003018576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJL4"/>
    <dbReference type="GeneID" id="9580773"/>
    <dbReference type="KEGG" id="tve:TRV_07382"/>
    <dbReference type="HOGENOM" id="CLU_020435_2_1_1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="14">
        <location>
            <begin position="297"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="731"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="82776" checksum="9CBBBCD0E8F0C168" modified="2010-05-18" version="1">MQHLGPPAARKGQSKGEKKERSRAGRENRLFTIPGWGWNGMTGRTVATACSAANPHPPPFVSEDGSKSRGEKAALHSHADAGGNQYESDCMDGRELLLIHGLLSASLPFPLLLRLLSAGAASAVLCPPPHHILRYLPASSSARRTQLRIASLQAPAQAAAQAAVVVAAAAAVVACCWSFAESWCRCRRGKRAACVICLWRLEESLQRQRQRQLQHPTSASLFITLHPLRPLQPRPRELPPGTAQHIQETKIRKIPRTDTPDTHSLTHSYSVYRDLVQDVSGFQPGKGFPHTNQRVDRRITVSVVASNVAVSSDIVTLDVGEDMTLADLKAVIQSEIQIPPQSQHLFHNNRPLADESKPLGQLGISEGDMLGMHIRVPTPASGPGQGNPSGAGAGAASQQGDSSRGGQPTIPDPETIRLHMLGDPRVLAAVRQQNPQLASAVDDPRRFREIMMSHRRAEARVEAAKEARIAMLNADPFNLDAQREIEEIIRQNAVTENLHTAMEHTPEAFGRVTMLYIPVEVNGHKVKAFVDSGAQVTIMSPACASACNIMRLIDRRYGGIAKGVGTADILGRVHCAEIKIGDMFLPCSFTVMDGKHIDLLLGLDMLKRHQACIDLKEGVLKIRDETVPFLHEADIPKHQDEFEDEPMVRGSDGAIIGGRTGAVQHPAAAGGTAAFPRPALPTSLHRPPPTGPSPGLSPAPRPGPAATPAATPAATPAAATPAAATANAPQQRASRWPADSIAKITDLGFTRDEAIQALDAANGNLDGAIGYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJV4</accession>
    <name>D4DJV4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018526.1">
        <property type="nucleotide sequence ID" value="XM_003018480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJV4"/>
    <dbReference type="GeneID" id="9584455"/>
    <dbReference type="KEGG" id="tve:TRV_07472"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_13_1"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="798" mass="89449" checksum="0223A1DA1A657CE3" modified="2010-05-18" version="1">MFHPSRRRCCLKLSSCLVVTLPALREREREEKKFDVVAFAFFGSSANFFSSPPDLQLHDNNNNSNENDNARGKSQHWRRPDRRLTLFLACFWCKASTDRRAQRDLRLHQPLSACENQPSLSHPPPSSLRRNASIVASRACSSAIHGASFISIGLLEAPVNGRPASPSLTLPQPPLYYEYYYYDYYYLHHHHHWAFAWALRLPLASRRHTLNHWRPTMNGGDLKKAAAAAANGTAGKKRRKASDLKPIITNEESDPATMSSTQSVYTSSLPISPLSRASSSSSEEEVDAADEEDSEDYCKGGYHPVSVGESYNNGRYIVVRKLGWGHFSTVWLSRDTTTGKHVALKVVRSAAHYTETAIDEIKLLNRINSANPDHPGRRHVVSLLDSFEHRGPNGVHVCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEVGDVEQIVKSCVKDEEKKADTRDDNRNGRRRRRTLITGSQPLPSPLSASFSGGDPFRNVTPSMQSSHSSLNQVLAESPLSATPTTPSKQSMKDKLGIKDSDAAADEKQKQREKTTSDLLEREVSGISLNKDTDQSMAGDQYNIDIISVKIADLGNACWVGHHFTNDIQTRQYRSPEVILGGKWGASTDIWSMAAMAFELITGDYLFDPQTGTKYGKDDDHIAQIIELLGPFPKSLCLSGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFSEEESKAVSDFLIPMLELIPERRANAGGMANHKYLNGTKGMDHISLNIPVGSRGEGIEGWASEVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJW9</accession>
    <name>D4DJW9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018498.1">
        <property type="nucleotide sequence ID" value="XM_003018452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJW9"/>
    <dbReference type="GeneID" id="9584427"/>
    <dbReference type="KEGG" id="tve:TRV_07512"/>
    <dbReference type="HOGENOM" id="CLU_051290_0_0_1"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="300" mass="33503" checksum="B5F6A2154F2B44EE" modified="2010-05-18" version="1">MISQANRDVQIKVQQAYESYRQASLARSLASMTLADGKAKIIPSPALVQYLSHTALTSGPKEIEKHYRDESVNCMVIWARPSRKILELLLGLQNRLKDVVGTESSRLHLSVVEISHRHPMAHLWSVFKQIGRPLVQEMLDLPASHAASHSRVARLGRPMLLFDAAGVAIAFAPVGTDTYTYHHLRRDLHSMAISSGVKTDTCYTACMGHITLGRFISTKHFDSDNVETAQERLRVWMATIQDINEELRQSYQAADWEWTVGEEKGLELQMGMLKFGRDTEEAEIAGRSFGGEATASTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJY4</accession>
    <name>D4DJY4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018479.1">
        <property type="nucleotide sequence ID" value="XM_003018433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJY4"/>
    <dbReference type="GeneID" id="9584408"/>
    <dbReference type="KEGG" id="tve:TRV_07492"/>
    <dbReference type="HOGENOM" id="CLU_622507_0_0_1"/>
    <dbReference type="OrthoDB" id="4173402at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="496" mass="57748" checksum="09C3EF99D8FE9429" modified="2010-05-18" version="1">MLENYPLDILRTIVSQLDDRVDLKSLSETSRFWNEVTNPFLYRNIFISTSRNDYGIIQAHLRAGVLQYTRNIQVLCSRSLTGPNDFDFEDYSPCTDSPNHYCTRFDSNESVIDSLYNWDLYQGLSSAELADKKRWIDPDGDPNFYPELFNLGSRRRILSVLIRCREGFLKSFRQPFIEQLRFGFLECCNLQHPQLFTRLKRLAILNAEESTFIDHESEVKNVRDCVTLNCGQLEYLEISCIYWQLLGDEYDIEDQHFTEALIKPCRNDQLRFPNIQHLVLEGYLFNKGRVSLLKDLNPEVLHTLSLRSCLFWEDLLPLLNSEDRPFHIRTLEVQAYSGSLPGVMDRQPEGCRELASFIEKCEALENLFIGIERAFGLERLWRSLLRHRKTLKSFVFYSLPGRIEGPHAAPTPYYVPNLSFDPPYHNEIESGRLTLKHLDLELLGVSYEPEYLVCFDSDSMLWENTNKSMLLDTSSLSANYHGQPESVAYSRLPYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK95</accession>
    <name>D4DK95_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018380.1">
        <property type="nucleotide sequence ID" value="XM_003018334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584302"/>
    <dbReference type="KEGG" id="tve:TRV_07616"/>
    <dbReference type="HOGENOM" id="CLU_002803_1_0_1"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="118"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="640"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="829"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1317" mass="148616" checksum="48A0D6A2D7BBD985" modified="2010-05-18" version="1">MRASINPLYEPSGSKEDLQPRADIVPGNVVTHIHSSQRPDALRSWISRYTHIPVQRQILMTAKGKSVKTQSLATENEIFVYDRQNVSEQASSSTPEELSPPLFTSQDPPDVLADRNNLQSWKDLFMARRSWALNLAAHCSTMAKSVDDYNIRIGVIQRGVSVALENLKSHVGNLEHKFQDTHNWANDLMKDQRSALKDWQRAYSTLGEIPAKSDFTFLRRAAPKKSKDYRTGTLQDYIEAEELQNAVSDVTSQSQRFARRVGDLEKEVRDISSQAESLGNAISNASANTPEQALLGEIEKHAKKIAADYTSVLSLQNDPGSISSISKVALVHTKKVLPKMMDLSLSLRDMLNATAQGLSTAMKDSSAQMQKISSIELRLAKVQADIAELNVETDSFDVLCLVYHLPSIYGSILIESTRRHEWTDKIKTDSRDIAEELAIFRDEEQRRRRKWAKLMGEFLNLPDDNAPSVEVNMQAAKDTDWPEVSRAEIEEYIDLIGKKADMEDAVQELTQLFKELDTPSRQQRRRTKAFKQGSLFEMGRSSFLLRDNDVVRSLQEEKSKVEERLKGSESRVRRLEDLLHRQSHISRPVSGQFGPDIPTSPASPRLENARLENASRRSSMSSRRMSSNQPQDDKALIQRIVALEAELAVERDAITKMQRETSLERQSNVDKIEEAELTKKDLMRNLEAKQREFEEERRFLELESSKFKSRIEELEDELDRVLDSHDHERHELDEKIESLYRELEIVRGKDKEDATTQVRLSELTDQNTELHEQIQSIHKEQKDLVQGLQAAYHNASNSMPPNNIRELVDALCVVVEGLAIHSKSSDEALARLGEENDEMKQKIAQSEQDAKTTREMLDSEKANASDLENKLKVVRAELEGVNERLKTGQNEIESLKAELDSERGKTQASDRRVMKAEKRVLDVNEQIKRMEEEKTSVSAELSEWKQRAENVHIDGKASSSWFDARGVRAGDMSVKVHALVEQLSRILEELGFTIVSQNGSMAIQRTSRVMNGLSVGENMSSSTLVGTITAPEHVHWAKAGNENDESSQFSSFMTAIDRMDIPACGDAVIKRVKDIEILARKWQKEARGYRDKYHRAQSEAHDKIAYRSFKEGDLALFLPTRNQEIRSWAAFNVGAPHYFLREQETHKLHTRDWLLARITKVQERVVDLSKSMNGANQDRLSTGGNDGASIEDDNPFELSDGLRWYLLDASEEKPRAPSTPGLGKSTVASAHVDAKGSIRLKRTTYGGGATKTLSKSLDSRRNSSASRNGAAIPTLQPATTSETVLASDGDQGAESRREEAQIFDEVRRDLLSDPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKD4</accession>
    <name>D4DKD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000466">
        <property type="protein sequence ID" value="EFE37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018338.1">
        <property type="nucleotide sequence ID" value="XM_003018292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKD4"/>
    <dbReference type="GeneID" id="9580033"/>
    <dbReference type="KEGG" id="tve:TRV_07656"/>
    <dbReference type="HOGENOM" id="CLU_036324_0_0_1"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50012" checksum="656660F161ADF4E0" modified="2010-05-18" version="1">MGKSIESMHSAFQLLKLTAVKTLLAAALIWLVIFQYCRYQFWRDPHSAFFNDRAGVYDLGYSLSREREAHHFITRNNARAEPPASIKGGTDPLFCVAFVTVRREADDYFDPSIGSLLVGLDPRERRALHLHILFADTDPKRHPSWGQIWVDRLADVAETYNVTASQLEHLKKLEKERNFYEKGVFDYVYALNSCKKSNAPYTVVFEDDIIIAEGWMAKSLRALADIKRMPSNKRPWIYLRLFYTETALGWESSDFAYRNMPLVFATVMLFTFSCLTVVRRLRSYRSLIDFPTTLAISVICVPAFIALVYMIGKYSLFPLHGVAEIAPYGCCTQGMVFPRDQVDGLVAYLQKRGHGQTDTMIEEYAEESKLTRYALIPQQLQHVGLKSSRDNTELNAQSTWAFYFEQNVPKLLRKEHDEILQDREIGALLDKHGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN3</accession>
    <name>D4DKN3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000475">
        <property type="protein sequence ID" value="EFE37589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018234.1">
        <property type="nucleotide sequence ID" value="XM_003018188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKN3"/>
    <dbReference type="GeneID" id="9579603"/>
    <dbReference type="KEGG" id="tve:TRV_07755"/>
    <dbReference type="HOGENOM" id="CLU_033661_0_2_1"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="40185" checksum="F54F2C1E8B069621" modified="2010-05-18" version="1">MASNASPSRAKASSGDPQSLAMKLYDQCLSSFPADHLFYQQDLLGLGVIPNDDLALLLRCTQILVDQSLLRLLQAKDDRLAWKIIAQSDAEKLVAFCPFDINNLNGEERLVYNVIHSTGRNGIWTKIIKTRTNLHQTIMNRCLKSLEAKNYVKSVRNVKYPSRKIYMLSGLQPSEEITGGAWFTDGVLDADFIRGLSGWIEHWVSARSWNSPGAEDQPKGKKRKLQADDSETQYIPYLPSYQGHPTTADITKAINGSGLTPVTMDEGSISQLLQMLCYDGRLISLRDGAAYRSVKKPNEISLQRDLGLQGPDGGANEGSALGSNGMTEAPCGQCPVFSLCRPGGPVNAENCEYFDEWLKSSALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKQ6</accession>
    <name>D4DKQ6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction protein Syg1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018205.1">
        <property type="nucleotide sequence ID" value="XM_003018159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKQ6"/>
    <dbReference type="GeneID" id="9579576"/>
    <dbReference type="KEGG" id="tve:TRV_07780"/>
    <dbReference type="HOGENOM" id="CLU_378646_0_0_1"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="196"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="732" mass="82706" checksum="6D2735D3D543EA17" modified="2010-05-18" version="1">MIPRRSFQHQQEDKVCFPSSLPGHPASHIVRFLLFRTRRTRRLFVGPIIPARGFRLLAPASFPPAKQQPQSQLIRIHPACVVVAVTASFLFFSSSLVSYLSSGICFAVRRLAVTASESKKEKTPSKEAEIASFLPLMSQQTRGSLPKPVCTFVVEAQRWKDLYIKRHRRGRPGASRDSDLLQELFILQSLQQQLAMNLPRYTPEDEVCKVSPTLRRDTWLLVTFDRAGGKKKVKAIARALRHVEQASWTPGRRRFSQISATRRDSIQFPLTPNEIPGLSSVTQRHAGDWANQAAPERSPLRTPASRFDQTEGYGSIVPPRPSHTVSPSLAPSSLQLPDPAIDPEDNYFTPRNESSTLHNDGLLAPYTNRQKNLRPGQNTQSGRGSLRKQIRDRRPTIGTPGPRPSFIHRMFSSSPEYENSKTQAPAREQALAELKTKEAEFFAFMDKELSKIETFYKLKEDESTKRLQLLRDQLHVMRDLRLEEIRLKKNQSKSESEEATNGIKGPAGQTAATWTRPLARGRGSHIGKTTKAMAQLSTPSGPVPRAMPDEQRDFVTRKEYQSVPYTSAKRKLKLALLEFYRGLELLKSYADLNRKAFRKMNKKYDKVAYARPTGRYMTEKVNKAWFVQSDIVENHLVAVEDLYARHFERGNRKAATHKLRGKAGIPTDYSPNSFRNGLMLAGGLVFGAQGLAYAIGHLFSDEIDVKTETSYLLQVQQTDTSTMGDLSNIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR6</accession>
    <name>D4DKR6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018215.1">
        <property type="nucleotide sequence ID" value="XM_003018169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR6"/>
    <dbReference type="GeneID" id="9579586"/>
    <dbReference type="KEGG" id="tve:TRV_07790"/>
    <dbReference type="HOGENOM" id="CLU_054062_0_0_1"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="32473" checksum="1C8FF81B36E4008B" modified="2010-05-18" version="1">MEVFHEAPNTSSFVPLAEHQSRTPASFYSGPPILHHFSERCKVVILEHDLLASPALNSLRWTTSEGSSNGTAQGERGVTAGTTVDEAAKDTKELSLPGVSVWVTSEYVSRSLGLYMQLAITSGGDENMDEDVDEDSISLTIIPLSGPATQPTDQETSAEEEDKKTQSQIEALFEAVSACSNLHPDPVDQDDEDRYEDADEGEEFHQQLQGSALFQNGLIFPGNNTGGLPPALPGSGGWITAENAHEYFDEDGNWKGGEEAPLGAGAGTVRPREDDDEGMNEAGASNNENGTSGDETKWRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKY9</accession>
    <name>D4DKY9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018167.1">
        <property type="nucleotide sequence ID" value="XM_003018121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKY9"/>
    <dbReference type="GeneID" id="9579538"/>
    <dbReference type="KEGG" id="tve:TRV_07863"/>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="552" mass="60355" checksum="B00A553557860898" modified="2010-05-18" version="1">MASPVTHIAPADADSFDYVIVGGGTAGCVIASRLAEYLPRKKILLIEAGPSDYMDDRVLKLKDWLCLLGGEFDYDYGTTEQPMGEFAGIDLRSNSHIRHSRAKVLGGCSSHNTLISFRPFEYDCKVWESKGCKGWSFDTFTRVIDNLRNTVQPIHARHRNQLCKDWVQACSTSLNVPIIPDFNRAIRSEGRLTKGTGFFSVSYNPDDGRRSSASVAYIHPVFSGAEKKPNLTVLTHAWVSKVNVSGDTVTGVNVTLQSGAKLTLCPKRETILCAGAIDTPRLLLLSGIGPREQLSALSIPVVKDVPGVGENLVDHPETIIMWELNQPVPPNQTTMDSDAGVFLRREPINAAGFDGDCADIMMHCYQIPFGIHTGRLGYDVPANAFCVTPNIPRPRSRGRLYLTSADPTVKPALDFCYFTDPEGYDAATIVAGLKAARKIAEEEPFKKWIKREVAPGPATTTDEELSAYGRSVHHTVYHPAGTTKMGDVQNDRMAVVDPTLKIRGLKNVRIADAGVFPDMPSINPMLTVLGVGERAAELIAEEAGWRPSSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLT9</accession>
    <name>D4DLT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_08163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000523">
        <property type="protein sequence ID" value="EFE37182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017827.1">
        <property type="nucleotide sequence ID" value="XM_003017781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLT9"/>
    <dbReference type="GeneID" id="9583724"/>
    <dbReference type="KEGG" id="tve:TRV_08163"/>
    <dbReference type="HOGENOM" id="CLU_1422384_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="21299" checksum="C43D7034665A605A" modified="2010-05-18" version="1">MLLRNSISRRIPQSPLHPRLSQMASHLIHSSSSINSSTTGAGEEKDQLYSSTTTTDAPGVSLADITKTNNFTSKLPPDAAFDTPLASHNAPREHLGPRLVKGALYTFVRPETTYEPELLAVSPRAMKDLGLKEGEDKTDDFREMVAGNKIFWNEADGGVYPWAQCYGGKVLFLGFRVIFFILFYFLCYEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYW5</accession>
    <name>D4CYW5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025799.1">
        <property type="nucleotide sequence ID" value="XM_003025753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYW5"/>
    <dbReference type="GeneID" id="9582042"/>
    <dbReference type="KEGG" id="tve:TRV_00002"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="192"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="7">
        <location>
            <begin position="365"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="6">
        <location>
            <begin position="615"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="83007" checksum="B3A680D94433CAAE" modified="2010-05-18" version="1">MQYRHETTPLLYIEVTRPPPRYPHRRIRRLCTTCLGSILALSVIVLLLPYALLPRGYGSISDHFPWTSSNGLDYASLQHLLQTVPNADKLRGWSHHYTSGPHLAGKNLSLAIWTKEKWEEFGVPDVQLTTYEVYLNYPVSHRLALLESKNEGHAFKVMYEASLEEDELDKDTTSELRDRIPTFHGYSASGNVTAQYVYVNNGDYDDYEALLKANVTLEGKIALVKYSGILRGLKVKRAQELGMVGVIIYTDPQEDGDMTELNGYKPYPDGPAREPKFCAERECWIFEQNPKEFLPSIPSLPISYKDAIPLLKALNGHGPKPSEFGKEWEGGLVHKGVDYNIGPSPENVMINLYNEQEYVTTPIWNVIGVIKGSIPDEVIVLGNHRDAWIAGGAADPNSGSAVINEVIRSFGEALKGGWKPKRTIVFASWDAEEYALIGSTEWVEENLSWLSSANVAYLNVDVSTSGKKFQANASPLLNKAIYNAAGLVLSPNQTIEGQTILDLWDGEIGVMGSGSDFTAFQDFAGIPSLDYAFTAGAGDPVYQYHSNYDSFDWMDRFGDVGFKYHVAMAKMWALTAAYLAESPVLALNVTDYAFALRKYLDSVKDKVSPDIMSQFDFSPMDDAISAFHQNAVKFDAYAESLATELEKGGHWWSRLILYFKIRFANQKYKYIERKFLYDKGLDNRGWYRHVIFAPGRWTGYAGATFPGLIESFEDNDLKNAEKWRDIIKSKIDDATELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZS6</accession>
    <name>D4CZS6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TRV_00318</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025556.1">
        <property type="nucleotide sequence ID" value="XM_003025510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZS6"/>
    <dbReference type="GeneID" id="9581793"/>
    <dbReference type="KEGG" id="tve:TRV_00318"/>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="21">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="651" mass="72910" checksum="77A2CC2A4A03F3C6" modified="2010-05-18" version="1">MASNWVRDEDDVEEEEDDIDDTDYKSSKDAVLFAIEVSESMLTPPPDFKSKKADKDAPITAALKSAYHIMQQRIISNPQDMMGVLLYGTKDSKFYDEDEEGRGTLPYPHCYLYTDLDVPAASDVKDLRALAEDEDSAAEILIPSEEPVTMANVLFCANQIFTSKAANFSSRRLFIITDNDNPHQNEKALRSAATVRAKDLYDLGVIIELFPISRPGEEFDRSKFYADIIYKASPTDPEAPAFPQAATKTATSGGDGITLLNSLISSINSKSVPRRALFSNVPLEIGPGLKISVTGYLIFKRQEPARSCYIWLAGEQPQIAKGLTTQLADDSAREVEKWEIRKAYKFGGEQVSFTQEEQAEIRNFGEPTIRILGFKPLSSLPIWASMKHPTFLYPSEEGYVGSTRTFSALHQTLLKQKKMALVWFVPRRNAAPVMAAMIAGEEKLDENGEQTIPPGMWILPLPFADDIRQNPETNHITAPDSLINKMRPIIRPLQLQNAQYDPQRYPNPSLQWHYKILQALALDEDLPEEPEDKTKPKYKAIDKANDMQRTGDLVIEWGEELEAQYRALEKSQPATSTLVKRPAPSAKGVKEEPASKRAKTEEPEDIKAYYEKGTLNKLTVAVLKDFLTSHSLPTSGKKADLVERVEEHFGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZZ5</accession>
    <name>NSCB_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactamase-like protein nscB</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Neosartoricin B biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nscB</name>
        <name type="ORF">TRV_00389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="ACS Synth. Biol." volume="2" first="629" last="634">
            <title>Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.</title>
            <authorList>
                <person name="Yin W.B."/>
                <person name="Chooi Y.H."/>
                <person name="Smith A.R."/>
                <person name="Cacho R.A."/>
                <person name="Hu Y."/>
                <person name="White T.C."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="23758576"/>
            <dbReference type="DOI" id="10.1021/sb400048b"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 7">Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025449.1">
        <property type="nucleotide sequence ID" value="XM_003025403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZZ5"/>
    <dbReference type="SMR" id="D4CZZ5"/>
    <dbReference type="GeneID" id="9581675"/>
    <dbReference type="KEGG" id="tve:TRV_00389"/>
    <dbReference type="HOGENOM" id="CLU_048478_1_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001018">
        <property type="entry name" value="Beta-lactamase_class-B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF2">
        <property type="entry name" value="LACTAMASE-LIKE PROTEIN APTB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00743">
        <property type="entry name" value="BETA_LACTAMASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000437902" description="Lactamase-like protein nscB">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A1D8J2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="F2S702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q988B9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="23758576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="23758576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="32255" checksum="9BD6B851F1D728BF" modified="2010-05-18" version="1">MHLQGTNTYLVGTGKSRILIDTAQKNCKLANQYQKGLPVWINRISSFLYTHKIELSYVLLTHWHGDHTGGVPDLISRNSSLADKIYKNRPDSGQNPITHGQIFSVDGATVRAIFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIEYLPGKLEEYIQHREGRERMMLSALTRQRVRGEGVREEGVKCGLTLNEIVMAIYGKLPPEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQRKRNKVRGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D001</accession>
    <name>D4D001_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025455.1">
        <property type="nucleotide sequence ID" value="XM_003025409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D001"/>
    <dbReference type="GeneID" id="9581681"/>
    <dbReference type="KEGG" id="tve:TRV_00395"/>
    <dbReference type="HOGENOM" id="CLU_061463_0_0_1"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="274" mass="30501" checksum="CDA15CE0F48D8C06" modified="2010-05-18" version="1">MTYLCPKFLSTKTSDNEEAEEQRRSIADSIEHPRLQPGADKMFSRAVLRSARELRTTSSIPPSASLLFASNRCLHQATAGSQFKATQPEIPPQGQTQNTERFSHLPTGSIPEVASISIPSAKPAVPPTFTSPLELTPAITALLPDLATQPSHYITAHLHARPYLLTAGDTLRLPFRMPNVQAGDVLRLNRASNIGSRDFTLKGAPYLDERLFECRVRVMGVEAEPLRIKEKTKRRQRHVQRVKSKHKYTILKVVNVRVKQLDELLAEGAKIVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D013</accession>
    <name>D4D013_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025417.1">
        <property type="nucleotide sequence ID" value="XM_003025371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D013"/>
    <dbReference type="GeneID" id="9581653"/>
    <dbReference type="KEGG" id="tve:TRV_00407"/>
    <dbReference type="HOGENOM" id="CLU_015562_2_0_1"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51580" checksum="32AFF9DCF27889A4" modified="2010-05-18" version="1">MGKPRVSTEKTPLLYIEEYKKLTALSTSSEGNKNREIHQTVPDHRIKLTPEGHRQALEAGRRLREMLRPDDKIHFFTSPYQRTRETTEGILKSLTSDDPSPSPFPRQGIQVYEEPRLREQDFGNFQPCSDEMERMWQERADYGHFFYRIPNGESAADAYDRVSGFNESLWRLFGDDDFASVCVLVTHGLMTRIFLMKWYHFSVEYFEDLRNINHCEFVVMQKNPDNGKYILRNKLRTWSELKKEREREREANNMPLTSPISPRRVWGGCPDGCDHARHKHRVTKRLLHQSTSTTGLVTGGEKTGSTEKEMELDDRYQNDDGDEEEDQDEGDSALAELCDQPVLQIKSTVSTSQGARADKTPRTVEVPHLGGRDAGGSNSGVSTGHTSPSPEKHAGSSAPTNNGDGNVRQGSGLKYTHQRDFDRDDDYPNEDDEDSEDERARLEEQSVQGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0G3</accession>
    <name>D4D0G3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025242.1">
        <property type="nucleotide sequence ID" value="XM_003025196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0G3"/>
    <dbReference type="GeneID" id="9580735"/>
    <dbReference type="KEGG" id="tve:TRV_00558"/>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="45832" checksum="D86828479E993966" modified="2010-05-18" version="1">MAQYFFDLLYTFTDCLCCFPSSPQLKINNRSFKLLRLLGEGGFSYVYLVQDKSTDELFALKKIRCPFGQESVSLALKEVEAYSLFTPNRNIIHSIDYSVVTESGSKFRSDGADAGSKTVYILLPYYQRGNLQDAINANLVNHTSFPERDLMILMLGVARALKCMHQYKVKDSASRGNGNGAAKGKSKGKPTRRTSRRVDDDEDESEHEPLMDGEVAISQEGVEEGEYRPYSHRDIKPGNIMIDDDGKTPILMDLGSLSPSPIAITSRSLAIAVQDTAAEHSTMPYRAPELFDVKTGSIIDEKVDIWSLGCTLYACLVGKSPFEARSEETGGSLAMCVLGGDWRFPDEKGGNTDAGKGKTRVSSQGNVADAGSTESGGISPPVKELVRRCLRVEPAERPDIDELIALIKETIQQLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0N3</accession>
    <name>D4D0N3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp40 co-chaperone Jid1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000037">
        <property type="protein sequence ID" value="EFE44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025201.1">
        <property type="nucleotide sequence ID" value="XM_003025155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0N3"/>
    <dbReference type="GeneID" id="9580694"/>
    <dbReference type="KEGG" id="tve:TRV_00628"/>
    <dbReference type="HOGENOM" id="CLU_063296_2_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="305" mass="35174" checksum="F0E5B230D1FDBB9C" modified="2010-05-18" version="1">MLRKSTLLCSCGGLQTLSPHSPLVRPEQPTYRRQSRRFAHVHGPVSDGVKGPEDDLSWPKSPSFTPYDLLRLERNAPYSKKRFYQLVKIYHPDGGCNGHPLCKDLPESVRLQRYRLLVAAHELLSNPTKRSEYDKFGRGWFQREELFGTQGPAAKSAMDAYYSRRRKVDPTIFRNASWEDWEQYHGQGNGKYQKQQQSTGASHETFASLFVLLAIFGGVAQAVSIGKYSSFVDERVKQVNRECNRFLEGRRHQTVTELESVDERVQHFLKRRDPSGYGLKEEEEETYRRHLGGSSHNIEPYHGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V6</accession>
    <name>D4D0V6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat protein poxJ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Oxaleimides biosynthesis cluster protein J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025123.1">
        <property type="nucleotide sequence ID" value="XM_003025077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V6"/>
    <dbReference type="GeneID" id="9580616"/>
    <dbReference type="KEGG" id="tve:TRV_00702"/>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="40243" checksum="17A6F3B4D3CF0EE4" modified="2010-05-18" version="1">MTGLFGNISSNTTAATSTTTGDISKDVALVAPPEDSISDLAFSSQSDHLAVASWDKKVRIYEINEQGMSEGKAMFEHQAPVLNCCWSPDGSKVVGVGVDKAARMLDLQGNPTTPVQVAAHDAPIRSCCMIQNPGNSAQPLLVTGSWDKTVKYWDLRQSTPIGTLQCQERVYSMDVSKTLLVVATADRYINIIDLNQPTNIYKVMQSPLKWQTRVVSCFTDGTGFAIGSIEGRCAIQYVEEKDSSSNFSFKCHRETPQGQSNVSNVYSVNSIAFHPQHGTFSTAGSDGTFHFWDKDAKHRLKGYPSVGGTISTSTFNRNGNIFAYAVSYDWSKGYTGNTPQTLNKVMMHPVTPEEVKPRATSANARRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Z6</accession>
    <name>D4D0Z6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pfs, NACHT, and Ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025084.1">
        <property type="nucleotide sequence ID" value="XM_003025038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Z6"/>
    <dbReference type="GeneID" id="9580564"/>
    <dbReference type="KEGG" id="tve:TRV_00742"/>
    <dbReference type="HOGENOM" id="CLU_044635_0_0_1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="52030" checksum="DEBE02A18D33ECC4" modified="2010-05-18" version="1">MEATWAPPDSPSYTAFFDAARQGTVDEIRAAYTSEIDINALQGDGFEGMSALHLACFHNGDVEVVRFLLDHGAEVNILDRDRAGNSYPLHWAANRDRADIVKLLLDRGAEKSRKGFDGRNALGMVLYYSLSPRKVEPKQMETIQVLLDHGFSVDESGMLFEAVLSRDQYLIKFLLDHGGSINPPSPKDPSLLGHAAGFTDYETVKFLLDNGAVLDNPTDGSPSSVLVSAASTGNLSVVKLLLENADPEIIRKSSRAISAAAASGHLKVVEMLLDSNMSIDGDCALGYQSPLHAACFTDQPSPELVKFLLSQGASVNSLDDRLNTPLHLHVSTSQPDERVVRLLLDAGADLSARNTNGETPLLRAVSALHCPYQQGNPHDPQGSASVVLLRRLLKAGSDITALDHLGQTALHILASNSPACTPGECPEKAAQVLLDMGVPIDSLDNKGRTAIDILLEKHTIESRLILHTIENFKLHQFSPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1G7</accession>
    <name>D4D1G7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024912.1">
        <property type="nucleotide sequence ID" value="XM_003024866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1G7"/>
    <dbReference type="GeneID" id="9580403"/>
    <dbReference type="KEGG" id="tve:TRV_00917"/>
    <dbReference type="HOGENOM" id="CLU_123412_0_0_1"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="130" mass="15357" checksum="2F592E80B09AF077" modified="2010-05-18" version="1">MSIIKEYNRSMKRIPCRYFQTAVKNWKQEVDEATQKKREAPPFRPGCYFGNKCHYAHIDPQTGQPYIFDAALIKEIDRKRSRRKTQRRGWSDIYDYPAFFGGGLEPDLEYAFLSSFLETGNDWDILDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1S3</accession>
    <name>D4D1S3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000058">
        <property type="protein sequence ID" value="EFE44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024809.1">
        <property type="nucleotide sequence ID" value="XM_003024763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1S3"/>
    <dbReference type="GeneID" id="9580299"/>
    <dbReference type="KEGG" id="tve:TRV_01025"/>
    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="472" mass="52208" checksum="B20DE569DDC65E57" modified="2010-05-18" version="1">MTEEEELLAKIGQLAGSQYTRHSRGGWRPYRGRGRGASRASAGPHRNRTLVLNNQSIPVEAASTAASSSTPSNEAPDSKPGIKNSWIAKRDRHMQLINSSIFDQETQARNKAIAETRRLKAQKKAAREESMVLRHAQSASRFSENNRSEAQPDGRAYTIYVGDIPFQVAQGGSKLISLSSEDMLLITIRSSRISLWFIDDPLKANVTPKRVKVGGVTFVRSKRGNLHRLGAVVSKNEKEKRAMQEVYIDGYQSLLPQNLFHRHRRHPSRLDMNASLLGRRAYRTCFKGPTCPYVHDPNKVAICKDFLQTGNCDAGVACDLSHDPCPERSPACLHFLRGRCTNPSCRYTHVHITPGAPVCRDFAILGYCSKGASCEGRHVHECPDYANTGNCGNKKCPLPHVDRAGQIRKFTANKVDPSAEGDSEEDVSSDDEVFEEIDSDDVDSDDLEEPEEIVQGTDGGDASQQLDFIGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1V5</accession>
    <name>D4D1V5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024775.1">
        <property type="nucleotide sequence ID" value="XM_003024729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1V5"/>
    <dbReference type="GeneID" id="9580265"/>
    <dbReference type="KEGG" id="tve:TRV_01057"/>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="195" mass="21659" checksum="00720CB79FBB40D7" modified="2010-05-18" version="1">MSLQPKFAGLKMAGAAEARHTLEIYLDYVCPFSAKLFKTFYDQVLPSLPEAASSRLTVIFRPQIQPWHPSSTLAIEAALAVLKLAPTKFQQFSAALFEHQKEYFDANVVNETRNQTYERLAKLASKEVGVDEEAVMGLLRISDKPGAGGDLNGGNGVTADVKIMTKSWCKGIEERSISSSFTKDQWLEWVEKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4D214</accession>
    <name>D4D214_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_01116</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024709.1">
        <property type="nucleotide sequence ID" value="XM_003024663.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582884"/>
    <dbReference type="KEGG" id="tve:TRV_01116"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_1"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000237">
        <property type="entry name" value="Putative Valyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="473"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="1139"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1421" mass="161320" checksum="73C6E38671C099B7" modified="2010-05-18" version="1">MATSAPPQPAFKGIVQSLGRITLKQPITWGFVTYRCSYNNEDAWQTILQRIRDEMAECLEDQGQEDLLPRHEMIIMDDKAKYDGATSHDIRDHFTSWVFNALPDIMVNTPTESRLQVTLVNDPHSMGLEHVFGTRYNFCLFVDDICLESVEHMDIPVVKLLAKHFGARDPEDRNYTIHPDFEDGETGGEEEDVGWMYLEVYQYVEKYDLLEEDHLWYEEYRRPPLLPWGSPSDQNPGSWRKNNHQSPSSSSQGNFESPKSYIEKIREAEAEADEKPGSIATLTDIPPHQSAVCWARQTLNSPNYPTHKTLFLFFHSYGQNRKPRYSDILLRARRGGEFTFDLDLQTWLHLLRRSLLVCVPINCPYDAVGKAESLTFACLRCLDTPADSTTGGVASPAQDAANNSSGTQGGKEKSERELEKERKKAEKLKKFAEKAAKKASAAPAPAKPTEKKPKIEKDKTTDAYDPKVIEAGRYEWWEERDLFKPEFGPDGKVKEAGYFVIPIPPPNVTGALHMGHALTKALQDTMIRWQRMKGKTVLYLPGYDHAGISTQSVVEKILWKTEKKSRHDIGREAMVGKIWEWTHKYHDSITASLRRLGGSFDWSREAFTMDENLSAAVTETFVRLHEEGTIYRGNRLVNWCVALNTSLSNLEVENRDLEGRTLLDVPGYSRKVEFGVLTHFLYEIDGTDEKIQVATTRPETMLGDTGVAVHPDDKRYQKFIGMKVKHPFVDRLLPIFADEKVDPEFGTGAVKITPAHDFNDYIRGKENNLEFISIMNDDGTFNENAGPFAGVKRFDARYQVIEKLKEKGLYVKWENNPMKVPQCAKSGDVIEPIMKPQWWMNMTELVKPAIKAVESGEIIIRPESAEKSYYRWMNNINDWCLSRQLWWGHQAPAYFVDIEGEKGDDADGNLWVTGRTEEEAKAKAEKKFPGKKFVLKRDPDVLDTWFSSGQWPYSTLGWPKKTHDLENLYPVSILETGWDILFFWVARMIMLGIKMTGQVPFKEVYCHSLIRDSEGRKMSKSLGNVVDPIDVMNGISLQKLHDKLLEGNLAEKEVAIATKFQKKAFPKGIPECGADALRFSLLAYSTGGGDINFDIQVIHGYRRFCNKIYQATKFVLGKLGDDFQPQATPTKTGKESLSERWILHKFNQAAKVTNEALENREFSVAANTIYQYWYSQLCDVFIENSKSLLQPDTDPAVQQSAKETLYTALEGALTLIHPVMPFVTEELWQRLPRRPGDKTISIMKAAYPEYNASFDDPAAETAYELILSTSKAIRSILAEYDVKTKGDILIQAYDATSHKSISEEAISIKSLSGKNIGELTVLDADNRTPPPGCVVSPVGAQAAVYLQVSDEVRLEQEEKAKASLLKLQETIKKQQAIITAPQWKEKAKPEVRELEEKKLVDAQGEAARLEEQIRELEKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2R0</accession>
    <name>D4D2R0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000075">
        <property type="protein sequence ID" value="EFE43861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024472.1">
        <property type="nucleotide sequence ID" value="XM_003024426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2R0"/>
    <dbReference type="GeneID" id="9579695"/>
    <dbReference type="KEGG" id="tve:TRV_01366"/>
    <dbReference type="HOGENOM" id="CLU_044117_2_0_1"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="371" mass="41014" checksum="4A35EF0983E0DAE6" modified="2010-05-18" version="1">MAETTATPAQPVEKVSDVIKNYRPAKLTIDGFSFQAFRGNPKADKQVNVTSLDFDDQGDYLVASGEDEMIQVFDVKEGKSTKTVPSKKYGVHLARFTHHSRQILHASTKLDDSLRLLDLHNESYLRYFTGHTDKVVSLAVSPGTDAFLSCSKDDTVAFWDLNSRNAQGKLKLATPYLAAFDPSGSVIAIASQSTSFVLLYDFRNYDKAPFASFDLSPLEDRYTPTTKGRAWTRLEFSNDGKSLLIGTDYHGHFALDAFEGNLKAFLVGKHGPTGRAAPVSTTGKPPGQGDVCLTPDGRYAIGGAGEQPDTLVWDLHQSPDAKLLLEPMTRLPYYRARTTLVQANPRYNMFATADKEIVFWLPEDPTKMAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2U0</accession>
    <name>D4D2U0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024433.1">
        <property type="nucleotide sequence ID" value="XM_003024387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2U0"/>
    <dbReference type="GeneID" id="9579655"/>
    <dbReference type="KEGG" id="tve:TRV_01396"/>
    <dbReference type="HOGENOM" id="CLU_042289_0_0_1"/>
    <dbReference type="OrthoDB" id="4833301at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="528" mass="59314" checksum="A6DAF72FC86A85E9" modified="2010-05-18" version="1">MTTITTERSPVLLRATSMTGGSPRLSLKREISPPSASDPQLLHIHERLNQLDAKVFDLRSSALTKESYVDRRNKEDEFLRREFDHQRAITASIEAVVGKTRSDVSHLKSLKTDLSCLGAEIFQLRTSVNHISSKDGFLHSDITQIRSHLDQLQHDVQRMHSDVCSTRIDVSGVQASVSQLKIDLMTMQRDTRQQFKHMDRIRFNSLAITAHAPITPVPVIGDDGSIKFPSYFPRTVWNFWCLKKMNRAHRLVELAEFYQLEGYQYWSRMASPHESTFAADGYMSDDSDSSELPSDITRSEAARLYPEACHQALAATLGLVYYKIRNEMGEGRHSHLMPAHAAAPKRTQEEIVSPQSSPRRRKVARRSQDIASPTGSALPHKIITNFMTAPAGDAKSIVSEGLDKLVWNVEQTQISEETMSKFSDFVRDEPNALLLLQALERGRIKLQPSHMERARVSPTETSSKRSFRSAKRGPHESGLGEAKSDDFPSEMNTVPTEIMSPHSASRSEAEQEDEDEAPPSSSPPEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2W9</accession>
    <name>D4D2W9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024462.1">
        <property type="nucleotide sequence ID" value="XM_003024416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2W9"/>
    <dbReference type="GeneID" id="9579684"/>
    <dbReference type="KEGG" id="tve:TRV_01425"/>
    <dbReference type="HOGENOM" id="CLU_1008986_0_0_1"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="31268" checksum="209C9A673DFF7F43" modified="2010-05-18" version="1">MRLKDVATFSALVDCLCNFLHEHTEKTNDIISPICPQTRPPGENKALKTLSVMLPGNVISALEAGVVSRWLTYYPFPCVLRDKSKKRSIVFMMKTWWADDPAMGSIVNTLSSEPEGLKHLRKFGLMGSRMEEHTTSLFGDEIHDDGDGALIYREDHQAYDTTDSGSDADSDVWMVDGEATAGMSPWLNSRPQETSAEEQALRRRRREAMVFSEGSRPLVADNIFHPVRSPDSDLPEEDWELGDDNPSWDTENSTELDMQEDPEPETTRSQWLLWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D309</accession>
    <name>D4D309_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024399.1">
        <property type="nucleotide sequence ID" value="XM_003024353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D309"/>
    <dbReference type="GeneID" id="9579621"/>
    <dbReference type="KEGG" id="tve:TRV_01466"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_2_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000208">
        <property type="entry name" value="3-ketosteroid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF10">
        <property type="entry name" value="3-OXOSTEROID 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="595" mass="63881" checksum="ABCA88CED3E60E84" modified="2010-05-18" version="1">MISRYTYRTYRGLSGVGRPGCCLSRHLVLRGRRTATTTSVPATFDEETDVLVIGSGAGGLTAALRAQSHGLRALVVEKDEAIGGTSAYSGGAMWIPNTHLSQAAGVKDSKEDALKYLEATIGDVGPVSSRERKVAFLDNGPRLVEFLEKAGFQWRLGKGGCPDYFPDIPGGSMFGRTLEPKIFNMKKLGSWRSLVRKRPGPPIAAYVTESNCALRSGASWSDFNALLKILLRQALLTLLGQAPSAMGQALVSQLLYLHKQAGTSIQRKTALVDLIMDGSTVVGATVKLEGGQKTIRASRGVLLAAGGFAHNKKLREKWGPSPASVEWTSAPPGDTGDAITAAMKVGAGTALLDDAWWGPTVVCPVNGMNVFALTERARPFSIIVDSSGSRFMNEAEPYTDAGHHQYERHQSVNAIPAWLIVDHSFRKRYNIGGLLPLQPDPKNGLESGHLFKADTIQDLARQIDVDAAGLEKTLSRFNKMARAGVDEDFHRGVSAFDRYFGDPKIGPNPSLGPIEKPPFYAARIYPGDLGTKGGLLTDEFARVLRDSDGKPIERLYAAGNTSASVMGRTYSGAGATIAPAMTFSFIAVDHMASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D326</accession>
    <name>D4D326_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024346.1">
        <property type="nucleotide sequence ID" value="XM_003024300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D326"/>
    <dbReference type="GeneID" id="9579485"/>
    <dbReference type="KEGG" id="tve:TRV_01483"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="286"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="587"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="90708" checksum="E7CC64C27ABEA1D8" modified="2010-05-18" version="1">MEALTIIIHSLGVGTEAAVDLVGEESIEEEGDHFPLEADTVLKSLEDSVVAKRDSTLETKLMNLSLRDSPSKPIVRPGYNNANERKVKLWANYFEIQGLEKVTLYQYYALLDPGVELGRHRTRRLLSLLVNHRSLTSHPVATNYKDKIISTKELNVKQVMVQYYEKEEQLSLNSPSYQVTIQLQRVFRMGEVLDDLKSSIETYNPDERNEAIQALNVVLAHFPNESANTQFLGQSKHFPLHDQRNKHEIGAGLDAIRGFFHSVRPSTGRLLLNLNVSTGAFYHAGTLHTLVCMFDQGRRLSGSVRLQELNKFLHKLRVVLSCPNNAISQATGIKTIQSIVKRNNLPGTIDNIQIKWPSGGREREVSVRELYRQVYSIDLIENDQIVVDVGGKGKPIYLPAELCHVVPGQPARQRLSARQTSDMIKVACCRPGANANSIVRRGLPLMGVMGDTGNIKSPKDFGIEVARNMLAVTGSVLSPPQLLYKYPVTVNRPGSWNLSKNIAFNKPGAFGPNNRVGCLIIIPYRGQGAPETTQFMTELGKHMKNYGINWPTDRISRDTIRLSPDEKDIENSLDEYFLRVKKLKQEFTLIVLPRYDAEIYSKVKYSADVKHGCHTLCVVPKPPKNGRPGEPLQVNIQPSYLANLALKINLKLGGVNHQLEPLKKYQSCPIMYLGIDVTHPTGTDSIPNAPSIAGVVANCDPMLGQWPASIRTQAHCVEMVENLGEMVIERLKSWKDQSHLPEKIIIYRDGVSESQYKQVLDLELPQINDAVYRYYRNGKYPKVTLIIVGKRHHTRQAYTYTFVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D329</accession>
    <name>D4D329_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024349.1">
        <property type="nucleotide sequence ID" value="XM_003024303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D329"/>
    <dbReference type="GeneID" id="9579488"/>
    <dbReference type="KEGG" id="tve:TRV_01486"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="483" mass="53408" checksum="32A60AB78ADEB103" modified="2010-05-18" version="1">MFRDETRKTAHKASTKTSKQRNSKNASPSTSTNLTNSIASTKLITLASSNTPEEVSRSLSISLNQQAICFFLHNYVVPCIPTSGRVGYLHSLQSTTSDAVLACMASVGMATLANINYSADLRIAAREQYGHALSLTNAMLRDPAKARQPAALDTVMLLGMFEVSPSPKHITVYESRANHYWRSHHEGALALLKINSKPGPEDIINFRMFVQARGQILSSCLLTSSRAPPFLQGVPREQQGCLPKSEGLLEDVTTLLVKLCNLRAEIEDRSLVLPEDIIPQAFAQEKDFTALYNELWEFYPYKTLAVIDREMPPSPADEVYGKYYHTYTDYFVPNIYNAIRGARILVTEIIEEAAAKLSPSSLLYAQYDNLSLLIEQSRAGALQAAIDICASVPYDLGSIEMKRQDGADIGRSGRALGGYVLLWPLCLAGDLPYAPTSLRDWAINRFEYIGRALGIKQAIWMAALLRMGGMRALLTTLRISDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J8</accession>
    <name>D4D3J8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_01658</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="2510" mass="279042" checksum="CA46E7EE01A956B9" modified="2010-05-18" version="1">MASNAQEPSSPSASSIFLPLCRRSRRGSHTSITSEAEKENLTEALDQIHSAASQMGTLTVFNEYTNPPVRSVAIDNKGLVGDLQGGLSGLYNIFKASVGGVREMVGGPSKAADALSQDPGNNDSSKAPVVGARLADTSSTHIASTQASAANSPVMGTFPSLSEGAGSSQPKTIKISSKAASVSSKTSIPAGNPLKSPLLPLSKVHQPATADPTVTEINVNAIKDGHHHHRSNSGSLSSSLLMNSDTITSERKDRPSHLSSSQVSQESTVAMRSQSPILLAKANSGSYRDFQESDFNQTAFPEPTSHDGSISPKLYSNSASRSGLSEMDTSMYSTQQKFNQVESTHDDKYRRKDTYPEDSNVSLAMDSGPTSISNSMSKFGGSTNDGNTIATLDTSVSMTDHGIPSAHSSKASINVPKEKLPPRVTQPHVPRFVFPSISSSESSQTVSTTGNTSKHVQKESEKASQTNNYPFYPRWGQSEAQTSIKNKLLSKEFWMRDENAKDCFYCGEPFSTFRRKHHCRVCGQIFDAKCTTLISGASFGYSGSIRVCKPCDAVINAPRDDSSDFSGDEVRNPVVINTRGLESPGDHLSLSNIGEDDASSTVSQSLDHVLKTPTMAIPATRRTGDGNHRRSAILEIDSDRQLARPTSSRSLKSGISRSHSVPHKRHHSRTQYIRNFKPYHDERAPFQRRFGDDTLGDKLPAFHRDNIIDPDLAQYLSDDASSEEDQPSLFSVVGEGSLSRSGGDSEKATFGGLLAAVKKGRSRFGDKSGLYPSRDIDDGSVSSSRAINLPRSARRRNLSVASSVHQRISPRNSKENPSLHHIHDISAPAFTTPANPATTGFKMTRSASMRGAGAPAIELNKASLDHVRKLLHQQLRDSSVPNCQSWETALLPILLKATDDVEPDVQHGDDMDIRHYVKLKKIPGGRPSDTAYVSGLVFTKNLALKSMPRNISHPRILIVTFALEYARQQQHFMSLEPVIRQEREFLENLVNRIAALSPNLLLVTKHVSGLALQLLEKANIATVCNVKESVVEAVSRCTQTRIITSMDRLAASLSYTGHCGSFDLKTYVYGKRKKTYVYISGCPKELGCTIVLRGANNDVLVEIKRITEFMVYVVYNLKLETCLMRDEFAKIPSSPSKLAQSGQKSPNPPGTQSGDDSTSYTVKSETADTPVPTDGDFGNEVSAPEKSLPAILTQGQPDESDVPPPAFYEDMVEKHQVKLLSASPFVKFHQPYLLMRARALERQLAYLKRLRDQDFSQESSPEEKTKSEKFFLITPEMIHESLSGASSKVKEVIHAVHDAEYDRALHHYETQKRQWEAYISGNRNLFDPHAHQNIVVLYSLVCTKTSIPCAGPDTFALAFYNQHEIDNKLFEEDCTLGQYVEDLCHSANAVCAANGCEERMFEHHRQYVHGEAQVSVFVQPYPSKLRGLQDTILMWSCCKKCGNETPAMPMSDSTWRYSFGKYLELSFSSADLHARAGVCPHDLHRDHLRYFGLKDMALRIHYDPINLLEIIVPRPRVTWKVDKDLRVRNEVYLAAQRRINKFMASVKARLKSINVESVMPEIAQACQQEVEALNKRANDDHLALIKEHQARYMNTRYWEVIPLNTVIISTQEKVVEWDAIFAEFERNYFPSEKDIRRLATLQLKKIFLDRDVSVTSLTSSEESGAIPVETEEGVTTPSGSPRLTRRMTLSPQEAKHMLASVVEEHTTKPIKQIEGEEPNPQTPTPGADPQEAGDISPMKPIIASENEFRHLDLAIPSNLVEKLSPPKANTPDNVDSNHPDNSTANDTPNPPVNEVEIPSEPRSSVDSNSNSHDVIEAVKRPSGLPRPRDRGPYNFKGKSPPLMRTLSQPAHSRQPLSSPVLPQDKPLKPSGEKPAEIGKGTFTSKRQRFSERLRLAGLKSPKLPGGPSLIPRSVAKKSSHVSYLTRHFEELSREFQKERIMQNHRRAAQGKQSRAYPMASSKPIVEVYKSVRDAVEEREPGYEEFPMSAPTAIVQKEEPVAPTTEIVEAAEPPVARPETPDKIIEERRTSDESLRDGDQTEQNLSGGDGEDEHSDGEKNYLDDSRNIEPSDEAASLSPDEIALDLKELPKHERTSLVKMLTNFWAERSASGWAPLDYPLSDSDHVFADCDIIVREDEPSSLIAFALNSEDYQQKLKSIQEQNEASDSVNVDAGPEVEQSLLRSTGTHLKYQFQEGQAKMLCKVFYAEQFDALRRKCGVADRIVESLSRCMKWDSKGGKTKSVFLKTLDDRFILKSLSTIETQAFLKFAPDYFQIMSEALFHELPSVIAKMFGFYQVIIKNPVTGVEFNWFLLIMENLFYDRTPTRIFDLKGSMRNRKVQSTGERNEVLLDENMVEFIYESPLFTREHSKKLLSQSVWNDTLFLARQNVMDYSLMIAIDESKQEIVVGIIDCIRTYTWDKKLESWIKDRGFAGGGKNRPTVTSPKEYKSRFREAMARYVLYAPEAVLTISLSSWHQFHAVNPNKQPPKIQNETKDTITPQSRLPDAAVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D425</accession>
    <name>D4D425_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024071.1">
        <property type="nucleotide sequence ID" value="XM_003024025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D425"/>
    <dbReference type="GeneID" id="9582764"/>
    <dbReference type="KEGG" id="tve:TRV_01838"/>
    <dbReference type="HOGENOM" id="CLU_046871_3_0_1"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="33248" checksum="D3ACB6B2A2F4D218" modified="2010-05-18" version="1">MSEPSMNTMEHGSTDPNISSGKRKREVMDTGDVQRLRSAHGGPNNFDVNIQATDNYGYDAHGMPSNTTDLSHIDQQLLQAVGNQNGVSDDNAMTAKAALAAHQPESKYPPPEPSFDNNGLGNNLSFGQDVGQVSMGPVQSHTSTAAAVYAAREAQAQAAQQISPKPTVGSAEWHQVRKNNHKEVERRRRETINEGINEIARMVPGCEKAKGSILQRAIQYIAKLQEDSKEMAARFDTTNMTTNQAITEISAQNAKLKNEVNLRSDIASKWIQRCRDAGLSFDDYDDEKSLTKLPVDESHNIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D459</accession>
    <name>D4D459_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000099">
        <property type="protein sequence ID" value="EFE43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023981.1">
        <property type="nucleotide sequence ID" value="XM_003023935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D459"/>
    <dbReference type="GeneID" id="9582674"/>
    <dbReference type="KEGG" id="tve:TRV_01873"/>
    <dbReference type="HOGENOM" id="CLU_027371_1_1_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="32739" checksum="8CB696E8FBCDBA6C" modified="2010-05-18" version="1">MHAILGLGASHLSVIRPHGDPTTDANAIEHRGQAIKGLNQLLVKPDPSSEELDAMLAACYALTMQSGYMFDALLDFVVFIRGCSLITTRIKQKDAGKSVFPVEQTADLNEFLPKITNNLDINPILLKSGIESVQSLVTLLEDETHAYFWKCLLDTLLAAQDSSEDTFLIYEKNYSAWYNLSTSQFSKFISAENTSTLILFAHHIAIETMMVPMLLSVIPARARVPEVTLYQVQWVDVIYRKLPSHLRKYVRWPIEAIAHWGMEYKIFSNEVGSKLRKTFLDHCENTMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4D9</accession>
    <name>D4D4D9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023904.1">
        <property type="nucleotide sequence ID" value="XM_003023858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4D9"/>
    <dbReference type="GeneID" id="9582504"/>
    <dbReference type="KEGG" id="tve:TRV_01954"/>
    <dbReference type="HOGENOM" id="CLU_1035077_0_0_1"/>
    <dbReference type="OrthoDB" id="4206905at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="269" mass="31094" checksum="AD1C57625711DB44" modified="2010-05-18" version="1">MENHTELNAEILDTLLGHKNQVSTKLHTIIKVLKPALNQEHIYLLEDKLLKYGIRKETMDLEKGGRFFKPMSQSVFESLPRLEEYYEEDGWDWDNEWVSTDDEIHDASHILVKLEGFIAGEIPNTPTDEWGCHRVLTDYADWDFAFLERTLYGGHWGSTGPGSEPTDWRFERAFDRHVRGTYLQPHVISLSVHGLYPDEDANLKIARSEVLVAADLMKERLKCPLYVTNDVYPVCHALVHYHLLTYSSRLTNHTTDSDGFLLQPTSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4K4</accession>
    <name>D4D4K4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023824.1">
        <property type="nucleotide sequence ID" value="XM_003023778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4K4"/>
    <dbReference type="GeneID" id="9582399"/>
    <dbReference type="KEGG" id="tve:TRV_02021"/>
    <dbReference type="HOGENOM" id="CLU_136890_0_0_1"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="151" mass="16606" checksum="ACDD354629A0C376" modified="2010-05-18" version="1">MSSLSAIMARRAFLRQQPVRRLVTPQPIRRHASSKAAEAGLDKGAKRDPELYVLLTVMAGAFGIVGWYLGSSPTSVSSESNVRVGESGAMPWETDEKDSESKGNFKYRYHPHGDKSKPLKEAPSALNEVIIPNVTLPAVCAWSYPAVRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Z3</accession>
    <name>D4D4Z3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000116">
        <property type="protein sequence ID" value="EFE43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023698.1">
        <property type="nucleotide sequence ID" value="XM_003023652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Z3"/>
    <dbReference type="GeneID" id="9582245"/>
    <dbReference type="KEGG" id="tve:TRV_02161"/>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="331" mass="36840" checksum="F39490701F15CAB2" modified="2010-05-18" version="1">MVSYKEVQASNARISESTAPQVAVFAGGTSGIGQYTVKALVGTGASMRIYLVGRKSSEERMKTFIQELQAINPRAEIVWTEGEISLLAETRRVCNVIKSKESRVDLLFLTAGYAPFAGRKETAEGIETSQSLEYYSRILFALHLLPLLDKAEAPRVISVMAGGLEKTSIDLDDLDLRKPGNFGSIKAQMQYGTMNSMGWEKLAQANPNVTFIHSWPGWVNTGNVRRGWDPNSIMGWVIRLFLETLLGVFSFSDEEAGQRHLFQCTSAVFGGRGVPWDGKPGINSLEKEENGLFLVNYKCDCTPNAKNMKILRYSALERVWNHTQEVLQPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D503</accession>
    <name>D4D503_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023664.1">
        <property type="nucleotide sequence ID" value="XM_003023618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D503"/>
    <dbReference type="GeneID" id="9582211"/>
    <dbReference type="KEGG" id="tve:TRV_02172"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_0_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055992" evidence="5">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="500" mass="54358" checksum="2231DB07017989DF" modified="2010-05-18" version="1">MHAIILKAAVALLGVSTAAGFSYQNSRLCLKLLAQGVEVDLPNSTDYETEQQNYWSTACTALRPDCIIAPKNARDMSRAVAAIQESKTTRFAIKSGGHSPNQLFSSIHDGVLISTRNLKQITYNEHTQTAILGPGLKLEEAVGGLKDKGQTVVGGRLGGIGVGGLILGGGLSFLSGQYGWAANNVVNFEVVLANGTIVNANATSNPDLYAVMKGGSGNFGIVTAFTVKTHTQDPEIWGGSMFFNGNHTESLTRAIRDFAEYNTDDKASIIGTVNRNPSLVWVVFLTYDGPSPPEGVFRNFTQIPNIRNTVKRQSYHSLMLANDEYIRHGNRFSIGAETSVNPSGTHGYDIFKSFIDHWNNVTDDFIDIPGSASSLALQPLPRSISTKAKESGGDVAGFDPRYDYMLLQIAVSWNSSTSDSVIEAATRKYYTVQGEMIKQFTNEGKLPKAYCPLYLNDLNANQDFWGRVAPSTREKALAVRRAVDPTLFFQNRVTGGFRLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5X3</accession>
    <name>ATP25_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>ATPase synthesis protein 25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATP25</name>
        <name type="ORF">TRV_02496</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023394.1">
        <property type="nucleotide sequence ID" value="XM_003023348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5X3"/>
    <dbReference type="SMR" id="D4D5X3"/>
    <dbReference type="GeneID" id="9583414"/>
    <dbReference type="KEGG" id="tve:TRV_02496"/>
    <dbReference type="HOGENOM" id="CLU_016140_0_0_1"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000404488" description="ATPase synthesis protein 25, mitochondrial">
        <location>
            <begin position="43"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="703" mass="78352" checksum="C1F1BE13E248282A" modified="2010-05-18" version="1" precursor="true">MSGIALQGFRCHACRNAAFRSFAAISSLSSSTRRPQSSISYPGSKLYQRNVRTTGRRQFSALGSVQSQADSDLPTKTETKEDTSAESSHIPWYLQDESHKPSSHPLKQQELPPLPENPPPILENLLQYISVDAGLDDLALLDLRGLDPPPALGANLIMIIGTARSVKHLNVSGDRLCRWLRSNYQLRPVADGLLGRNDLKIKLRRRARKAKVTGDASSLNSRDDGITTGWICVNVGDVENGPLKTKNSRNRNFIGFGGTEDKVRIVVQMLVEETRSELQLEALWGSLLNPEAGEMNPAPRDDVWGDLSSETTSSGKGVDSIASTFSQRFPGRRHIHTQARPNTPEPLSHETLGDIVQESRPALPSKIVSTSMASPNVSSLLEQLSRLPEEEARRELGLGPGDRDSTLFLRLFYEAVSKSDTETVLIDKLSFARAAVLLKHPAYRKADLYRAFKSMAASGCSISEELAMDTVRTLLSFQGPENAANERVPEQDIDLALRVLEHMSLRGINIFNGEVFFLLHKASAFQSHVPANDAPGAMNTSVNPDSVSKVQVEELDRITTVHNRLSKLMASANVDFDYKDYPELLKMYFEHGNYSNFWRLWHRIPLMQIPRTKELYLLMFRLHAKLGHQRQAVDCLSSWVPMMAREQPPVALDEELTRAIMACMLVADPAIDQKTDDGTVSQFTRLWKQCLRDLESFKAANSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6A5</accession>
    <name>D4D6A5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ER membrane protein (Pkr1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000135">
        <property type="protein sequence ID" value="EFE42621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023239.1">
        <property type="nucleotide sequence ID" value="XM_003023193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6A5"/>
    <dbReference type="GeneID" id="9583257"/>
    <dbReference type="KEGG" id="tve:TRV_02629"/>
    <dbReference type="HOGENOM" id="CLU_006343_0_0_1"/>
    <dbReference type="OrthoDB" id="5342685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="296"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124467" checksum="5A5BD28687B51513" modified="2010-05-18" version="1">MASIFTFDPDLPRVSSPWSSSGATTPRHQKGGQNSSCGPSPIDTSDPGFLEACGIKKLEPEPQDGPTEYKLHLLLRPRRPFVSLSSGAQVSGSHHSKSHGNSVAERDVSESPEPASRGAQSSSNSPRQARLCQLTTQLLWRLQQSSPFHSSSTANLVLPALPEATESLNVPSTLSPLLPGLEESQGALYEIGVTDDGTFAGLAEDELDESLVNLQAMAASLGCRVEVLRRVAVGYCEWVEKDGLSTRTEKLWVAEALVSPDLKQCRSQVLTGDPSGRWKENGGRSSMTQQPVLTEQLNVAIAGASGSGKSSLLGILSTSALDNGRGKSRLSLLRHRHEIASGVTSSIAQEMIGYPAPVNDDKQVTASSDVINYASGNINSWDDIHVSARGGGRVVFLSDLPGSLRYVKSTLRGLMSLRPHYVLLCVPANNPEDPGSIIPPEVGMSLAYLELCVKLEIPVVVVVTKLDSATRSSIRQTLAQVLSAIKSAGRKPVMLPVPGEVNEQDLDLSNISPGDRKDANAAINSMGGDCLDDIPIIITSAVTGAGVGKLHALLQTLRMPTPEKISPPVKKSNEDDDEQPKSLFDISEVFEMPLFKVYSLSSEGQRQNDRGIVLCGRVRRGAISIGDRLVVGPIIPESRSHEPTHTPPRAKAAYSKSLPDSLPSSRFRKFTGDSLEAQSQTHAVWKQVRVVSVRNLRLPVKALFEHQIGTIGVDFVDSSLSTSLGRMRKGMVLADFNCGYLSNSLLSSQRLSTSAPPFHSGFIARFHASDFSASPPVLVSGSTSVVYIESIRAAARVILVEQTRPHISPSHGIEPEIFMLDAADHHNTERCHGDDEISVTFSLTTSVEWLEVGSLVLAVPVLPASTASLAEFAKSFMFDIFDYLAPSCLPYARTQQLPTSQGHIHISSGLDKAPVLTEARLDSTTSARAESFDQQYPDNILQVPCDTFEIHKRTSARALMAEFFQELFSSIFTPGATPTLLLATNATFAALQVVFFVLLVATYSIHFLILSCISGALWYSINWFADEVKAENERQKKLAEGKEKDDRGSSTDLSSLRVKKEASPVARLSGAMSDSAESGTETESIRAGHIGTPKVSGASPLSGGATARRTTPSASGVQVTLTPESSMDELTLRKPSGDSSGYISTDSEWEKVDDKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6G6</accession>
    <name>D4D6G6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023169.1">
        <property type="nucleotide sequence ID" value="XM_003023123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6G6"/>
    <dbReference type="GeneID" id="9583189"/>
    <dbReference type="KEGG" id="tve:TRV_02691"/>
    <dbReference type="HOGENOM" id="CLU_010672_3_1_1"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="88816" checksum="9832DA0A8D3EFF90" modified="2010-05-18" version="1">MADDEIQRLREQLRNEERRRQKAERAQQEAERSQQEAERARQDAERARQEAEQLQQTFEEQLRPLTLFEYLDACHTYLFSGLVPRTLKSSTKGSADNARGKFRPHRIRKWRSFDDEQAEIWDHLLSQENKGFIAQLKFDSLHGMMTIGKKTKKKISSELDLRYFQRDAITEPVGSIIEAFFESERLRHVFGLQGQVTFENHANSLADSEEVEGVRGRPPKLRKGTDGAATPTNAEPSHRPLADEFCIYNAGEKAKKPALVGELKPPHKLPLEAIKKGLRKMELDEVVERRNDDTENIRHRRLVAAVITQAFSYMIKAGVEYGYISTGEALIFLHFKTDEPGTVYYRLSVPEADMNQEGEDDDTNRLRKTAVGQVLAFTLRALRTTPHDQNWKDWAMSQLKVWVITEGDLYLPISEEDEKQDEQPPTPYKPSKSTQMAIRNTPVRTRSRSSRSTCKPTSSQQNSSGEDDKDDESDHDSPSRRPRRSANVMVLIPPPQPPNSDSSYTGPVCRDGARRYCTQKCLLGLLNGGLLDKACPNVKEHGTEVHQIDHSMFISLLLAQILQKIVSPWTQPLGCESLHRHGARGALFEVILFKYGYTLIGKGFPPEFSKYLRNEQALYNQLRPVQGVHVPVCLGTIDVSKRPMFYDGIADIPHFLLLAHAGTEILKCGVAKDKIISAASESLRAIHALGVLHHDVEPRNLFWSEEGENVLVIDFERAEILRSERAPLGRMSLNRKRKNENESREEETKVVARESWIDNRLEEELKGMRGYLKRNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6N8</accession>
    <name>D4D6N8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023075.1">
        <property type="nucleotide sequence ID" value="XM_003023029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6N8"/>
    <dbReference type="GeneID" id="9583095"/>
    <dbReference type="KEGG" id="tve:TRV_02765"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="550" mass="60078" checksum="E193A9CD1F5CC8E6" modified="2010-05-18" version="1">MALGILEDSKLDNVPGTTYVLDDDGSSVETPVPEESHLKYDKSGAVPIILVPQPSDDPNDPLNTDELQNWPLWKRDLILVILSVTSVICATTSSIMAANTVTIALNYTIDFTQAALLTGYHLCGVGVAGIIIVPTARVWGKRHLFLLGNLIIVISCIWAGLSKRNHTSLIWARIWQGVGLAPFEALVNAVVGDLFFVHERGKRMALSNVALFGGAFLTPVIAGKMTHTLGWEWTFYFIAIFSGACLPFVYFFVPETAYKRAQHLNTDFSGDVDRRTARAAAQGTIEKEADADSAAGPSSAAVAANGDTVQPDVPRKATFVESLALFNGRKTDESFWKLLLRPFPLFLHPSIAWLPQACLIQGVIIGWTVFIGVVLAAIFLGPPLWFTEEQTGYLYTGAFIGSVVGLFLSGLFSDWSANLLIRANKGKYEPEFRIWLVLPQLVFSGIGLFGFGFASGNVSKYGWVIPDVFFMFVLIGMVMGAVASALYIVDAHREIAIESFTCLLVFKNMFSFLLTYFAYNWVVLGGAKKVFLIIGGIEVAVCLLSVPMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q7</accession>
    <name>D4D6Q7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023094.1">
        <property type="nucleotide sequence ID" value="XM_003023048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q7"/>
    <dbReference type="GeneID" id="9583114"/>
    <dbReference type="KEGG" id="tve:TRV_02784"/>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="283" mass="31749" checksum="4860BE37D2016C43" modified="2010-05-18" version="1">MVTYMKLGGELSVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEKHVQAISEYRQKIEQELERVCQDVLDVLDQSLIPKAESGESKVFYHKMYVSLILQKDRKSILMLYYRKGDYHRYLAEFASGNKRKTAVTAAHDAYKNATDVAQTELSSTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELESLSEESYRDSTLIMQLLRDNLTLWTSSESGEPEPNMPQGQQAPAEGATEEKKTEEAPADDAAAKTEEPAAATEAKKEEPAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D719</accession>
    <name>D4D719_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022992.1">
        <property type="nucleotide sequence ID" value="XM_003022946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D719"/>
    <dbReference type="GeneID" id="9583012"/>
    <dbReference type="KEGG" id="tve:TRV_02898"/>
    <dbReference type="HOGENOM" id="CLU_029790_4_1_1"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="41213" checksum="761A472CC6516C85" modified="2010-05-18" version="1">MECRWPLVLRFIKGAIHGAILLPVLGHAIFTVIVVILDKHVFDTVGVPPTIIPSLSIVVGLILVFRNQTSYNRFWDGRNCLTTITTALRNLTRTILVSSRNPNGPLSDAEKQDIERTIRLLIAFPYAVKCYLRAEWSTEWGAVSNPNMIADVVRRQEAGGPKQEFLSLLPAGFQAHEADGLGLPLQLTFPIDAFIQRGADRGWYDPPMANQMGNQVSAMIDAYGKMETIKLTPIPVAHLIHQKQVLALFGCVLPFAMVDDMGWWAVPIVCLVIFTLYGIEGIGSQLEDPFGYDKNDIKMDAIVEDERVEIEAILNEWKKLNDLPVDGDDSATNGARNGVRNGTSNGTRNGTHNGTHNGVTNGNVAPREMFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D735</accession>
    <name>D4D735_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022927.1">
        <property type="nucleotide sequence ID" value="XM_003022881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D735"/>
    <dbReference type="GeneID" id="9576985"/>
    <dbReference type="KEGG" id="tve:TRV_02914"/>
    <dbReference type="HOGENOM" id="CLU_2869272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7312" checksum="8117C30452B0CA55" modified="2010-05-18" version="1">MREDDPGSFESGLLVFVFIVFIVHSVYFLDFLDFFDLVCSSGRKFQCEQRRSGSSSSSRFNGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7M7</accession>
    <name>D4D7M7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022729.1">
        <property type="nucleotide sequence ID" value="XM_003022683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7M7"/>
    <dbReference type="GeneID" id="9581454"/>
    <dbReference type="KEGG" id="tve:TRV_03111"/>
    <dbReference type="HOGENOM" id="CLU_1817205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="142" mass="15804" checksum="5398EF02B6BE9E79" modified="2010-05-18" version="1">MLTGVADPEDVEDALDVGRHFAKGLVARHILTIVVIVGCFYLLFPGWVGLHPRELLCMAPVDAQDRGLDPGKQVGLLARAGADGVLALLRQVDHSQALLLSLSLSLSFPFYTDMRWKKEEDEDEDEDEDEDEAKKTSEKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7T3</accession>
    <name>D4D7T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022706.1">
        <property type="nucleotide sequence ID" value="XM_003022660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7T3"/>
    <dbReference type="GeneID" id="9581364"/>
    <dbReference type="KEGG" id="tve:TRV_03167"/>
    <dbReference type="HOGENOM" id="CLU_106477_4_0_1"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="102" mass="11500" checksum="78CC064D814B7417" modified="2010-05-18" version="1">MLATAEETLYPPPALEEGQSIARVVKATGNNIYSVELPSKESILVELPARFRSTIWMKRGTFVVVDSTALEERDNKLSGEIVNIVRDDKAWRKADFWFVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7X6</accession>
    <name>D4D7X6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022689.1">
        <property type="nucleotide sequence ID" value="XM_003022643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7X6"/>
    <dbReference type="GeneID" id="9581348"/>
    <dbReference type="KEGG" id="tve:TRV_03210"/>
    <dbReference type="HOGENOM" id="CLU_117317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="202" mass="20973" checksum="21CF37E833BABC96" modified="2010-05-18" version="1">MVNFSPCAASSSSITNSHHHHQNNNNPPIESPAISSSLALAARSLFSLSSASVMGLASKMAAANQGAPSSYPGGPPPPGGGGGPAYPGQQQYQAYPGPGGPGGPPPPQLLLLLFLLSSGNIALKNLCPPLFHPLSAPVLCCRCRFVLLLVPVPLFACDVITMACFSDQVTNLYNYAFDREPIAKEKAFAGLAHDHSNQSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Y7</accession>
    <name>D4D7Y7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000165">
        <property type="protein sequence ID" value="EFE42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022661.1">
        <property type="nucleotide sequence ID" value="XM_003022615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Y7"/>
    <dbReference type="GeneID" id="9581319"/>
    <dbReference type="KEGG" id="tve:TRV_03221"/>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="28984" checksum="2BDEA6FC011836BF" modified="2010-05-18" version="1">MSLVSGPGRGGSTSGAQELYTQKHVDYIKSLDTRRDELEYWLTEHLRLNGVYWGLTALHILGHPDALPRDKTIEFVLSCQREDGGFGAAPGHDAHMLHTVSAVQILVTLDAIDELNKDGRGGKEKVASYTRFLYGAFNALSLLGLLHLVDTEKAVTYIQSCANFDGGYGVRPGAESHAGQIFTCVGALAIVDRLDLVDTDRLGGWLSERQLENGGLNGRPEKKEDDPEHGGIADRPEDMVDVFHTVFGLTGLSLLKYPGLKEVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D803</accession>
    <name>D4D803_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lignostilbene dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022650.1">
        <property type="nucleotide sequence ID" value="XM_003022604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D803"/>
    <dbReference type="GeneID" id="9581309"/>
    <dbReference type="KEGG" id="tve:TRV_03237"/>
    <dbReference type="HOGENOM" id="CLU_016472_4_0_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="585" mass="65402" checksum="3468D2DC57DD0D5E" modified="2010-05-18" version="1">MHNTCPPTPCRYTGDIPEEFNGGQYVRNGGNPSMNHEYGRDVHWFDGDGMLSGVFFRKVKGKAVQPEFVNNYVLTDILLASRANPKLRVPILPSVTTLINPSSSIFKIAYAICRAILLVLWSYVNGSKWSIKKISVANTGIIYHSGRALATCESGPPMRVTLPELDTVGWFNGLRAEGEPEDSISPSLTGFGGPGFTGFLKKWTTGHPKVDPISRELIVYHSTFAQPFVHYSVVPDLRAQEASLEQSEPLFNLPVPGVKSAKMMHDFGVSRQHTIIIDLPLSLDPLNLAYNKPVIEYDFYGRTRFGIFPRRKPDQVRWFETEPCCILHTVNSWDDRITDKGATVNLLACRMTSAAIVFNTGNIRPPPNLRNIEEECRLYYFQFGLSQAENIISHQWALSVISFEFPHVPQHLAMSATQYVYGCSTSKGTFSTALGGATKIDCLAKLDVKALISKGLRSPPRSVTGSVDSRSIQEILTSNDPDDPIKIFQTPSGWYLQECCFVPRTNGVSEDDGWLLTFVFDESQLDEDGFAPVGSKSELWMIDAKTMRMVTRIYLPQRVPYGLHGWWFSEDDVCNQRAVETCRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D808</accession>
    <name>D4D808_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sec23/Sec24 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_03243</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022586.1">
        <property type="nucleotide sequence ID" value="XM_003022540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D808"/>
    <dbReference type="GeneID" id="9581251"/>
    <dbReference type="KEGG" id="tve:TRV_03243"/>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="13">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="14">
        <location>
            <begin position="373"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="16">
        <location>
            <begin position="632"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="15">
        <location>
            <begin position="752"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="12">
        <location>
            <begin position="889"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE41968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115338" checksum="EA376EFE1DF1ED55" modified="2010-05-18" version="1">MADFSMYHNLGDGAMPGDERMKSQIRTGPAAPQFVPPVAQPPSGYMQSGGAPQQTYQHPHGFTQSSPYPPSSAGYPSPQGNVQSPADMQSGMHNLTAQMGGLGIAGGGPPSSAGGTTRAHKKKDRHAYHEFGAPAGSSQAFNGMPPGSTQQPSQFLNQQSPQVAPPHGGFGSPQVQQQRNSSVVGDGAVPTQGRVDPEQIPSVPRSRDVPAQYYLEHTYPTMERHVPPPSTVPFVAHDQGNSSPKFARLTINNIPSTAEALASTSLPLGLILQPLAPLDEAEQPVPVLDFGDSGPPRCRRCRAYINPFMTFRSGGNKFICNMCTFPNEVAPEYYAPLDPSGVRVDRIHRPELMQGTVEFLVPKEYWNKEPVGLRWLFLLDVSQEAVSRGFLEACCDGLLSALYGSDGDGEEPESTEDGESKPRRNLPEGSKIGIITFDKEVHFYNLSPQLEQAQMIVMPDLEDPFVPLSEGLFADPYESKHVISSLLTQIPTLFSFIKYPEPALLPTLNSALCALESTGGKIVCSLSCLPTWGPGRLFMRDQGMGPGTDAERKLFTTEHVEWKKTATKAAETGIGVDFFIAAGGGAYMDIATIGHVSAVAGGEMFFYPNFHAPRDIQKLSKEICHSITRETGYQALLKVRCSNGLQISSYHGNFLQHTFASDLEMGSIDADKAFGIMFTYDGKLDPKLDAHFQAALLYTAGNGQRRVRCINIVAGVNDGGMETMKSLDQDAIVSILAKEGRQIFIFLLVSVVVANVPRLAASKVPEKALSEIRASLTEKSIDILASYRKNFSLSHPPGQLVLPEYIQEFSMYMLSLLKSRAFKGLFKAINKYTRVSTGGHEPSDRRIHDVRMLRSFGCRELSLYLYPRIIPIHNLDPKDGFSNEHGQLQVPPSQRASFSKIEDGGVYIVENGQICILWIHALVSPNLLEDLFGPGYNSLKSLDPNTSTIPVLETQLNAQVRNILQYLSTVRGSKAMTIQLARQGIDGSEYEFARMLLEDRNNEAQSYVDWLVHLHRQINIELGGHRKKEDGSVAGAVGAGVESTLSGLAGLRPSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D857</accession>
    <name>D4D857_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022635.1">
        <property type="nucleotide sequence ID" value="XM_003022589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D857"/>
    <dbReference type="GeneID" id="9581294"/>
    <dbReference type="KEGG" id="tve:TRV_03292"/>
    <dbReference type="HOGENOM" id="CLU_010591_2_0_1"/>
    <dbReference type="OrthoDB" id="4173988at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055658" evidence="3">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="176" mass="18617" checksum="E64F193AE9DC7E0E" modified="2010-05-18" version="1" fragment="single">MLNIPLILGAIILLGTRKAATAALPPRPCAFAVTAANDDTCQSLGAQWGIGMAQFLKWNPGVNCNALVAGKTYCLSAGDSEPGPTASLTPSPQVPTTSRATQTMISKASTGTLVSRSGPIKFLSGMASDCLFYHPVSPGDTCQSIVDQYKAFTLDQFYTWNPSVGKNCESLWLGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D888</accession>
    <name>D4D888_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000171">
        <property type="protein sequence ID" value="EFE41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022562.1">
        <property type="nucleotide sequence ID" value="XM_003022516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D888"/>
    <dbReference type="GeneID" id="9581220"/>
    <dbReference type="KEGG" id="tve:TRV_03324"/>
    <dbReference type="HOGENOM" id="CLU_601573_0_0_1"/>
    <dbReference type="OrthoDB" id="4174420at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="50305" checksum="4CF38A3B909B8856" modified="2010-05-18" version="1" fragment="single">GMSYTPSYANDEHRRIAAAALRLSRLHPPASVSSSGAPEPDGAVRVPQAAYILDAGCMDFPVDIEVVDADADADAADVDADTDRDAEDWRRIKMLAADSTGSTEGSQLRTDLLSHSHSHSLSHSRRSHQSHRSRLSQQSRRHSSQADHQDAAGRDHEEEEEEEEEEEEHEYEEEEYDEEADEDELEPGCSHENAFFVLLRISFCLPPFTIFAALYAFISLIFLLLAIPLRLCPPSHFFKPPTSLTEQVCRLLVPLLRLNRRTVTSPTNNNHDHGRSSSRSSSSHHHRHDHHNNHHAKRSRRHYSTHSSLPASALTSPRQSYTISTSTPVSASFSSSTIPTQPVTATDSASIPASTTTPAAAAADSSASRLYANYSAPMLVFVHLLSPLLLPPTLLAAWICACFWIFVMIMGNPDGKEKTDDGRAAVLAVRNWWCLWLASARRKRRKRDPEAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I3</accession>
    <name>D4D8I3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022469.1">
        <property type="nucleotide sequence ID" value="XM_003022423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8I3"/>
    <dbReference type="GeneID" id="9581046"/>
    <dbReference type="KEGG" id="tve:TRV_03419"/>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26557" checksum="590E15B8CA060CC6" modified="2010-05-18" version="1">MEALKAVFFKPDPAAQRLISSHQMRKCNALIRSNTRKLDRDISQLKAIEIKTKQFIVAASKRAQRNPSQAEQAAKETRIFARELIRIRKQSARLTTSKAQLESVKMQVNEAFSVRKIEGSLRASTSIMKDVNTLVRLPELTGTMRQLSLELVKAGIIEETIDSAMPEDQLLEEEEEEADNEVDKILQEILQGRLAATGGIKPEETLQTEEPVPEEFEDQEATLEQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q0</accession>
    <name>D4D8Q0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_03487</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022423.1">
        <property type="nucleotide sequence ID" value="XM_003022377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q0"/>
    <dbReference type="GeneID" id="9580970"/>
    <dbReference type="KEGG" id="tve:TRV_03487"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="285" mass="31141" checksum="F265BC861210566A" modified="2010-05-18" version="1">MTPLPHTPSLGDNFLSSGDNTDKLSLVGQRKVLKPNEFQKFVLKEKTIVSHNVAIYRFALPRPTDILGLPIGQHISLAALVEGQTKEIVRSYTPISSDDNAGYFDLLIKSYPQGNISKHMTTLKIGDTMKVRGPKGAMVYTPNMARHIGMIAGGTGITPMLQVIKAIVKGRPSNGGNDTTQVDLIFANVNVEDILLKEELDELAKTDKAFRVHYVLNNPPEMWQGGVGFVTPSMIKAHLPAPADDIKIMICGPPPMVSAMKKATESLGYKKANLVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S0</accession>
    <name>D4D8S0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000182">
        <property type="protein sequence ID" value="EFE41752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022370.1">
        <property type="nucleotide sequence ID" value="XM_003022324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S0"/>
    <dbReference type="GeneID" id="9580918"/>
    <dbReference type="KEGG" id="tve:TRV_03508"/>
    <dbReference type="HOGENOM" id="CLU_1972072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="127" mass="14888" checksum="34C18FE7E9F0F6A7" modified="2010-05-18" version="1">MKYLYMWFLQSLNITPCSIGPQAYFAKVKKGKTKSNNKLNLKNEKKKENSAEKRSKERKKKWKLEKENMTLIGSKLGTFIRFPIFLLLFMVSLDVREPERKKEGGEDDIAGLLVQITRIYALTEHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D998</accession>
    <name>D4D998_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000188">
        <property type="protein sequence ID" value="EFE41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022208.1">
        <property type="nucleotide sequence ID" value="XM_003022162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D998"/>
    <dbReference type="GeneID" id="9579093"/>
    <dbReference type="KEGG" id="tve:TRV_03689"/>
    <dbReference type="HOGENOM" id="CLU_906704_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="307" mass="34153" checksum="1EBD801740A28C49" modified="2010-05-18" version="1">MDRVKWTGKEDKMAKRKKTKKRKTKKKEREREREEAKGKKKKKKKKNNKKKNKKKEKKYSRVARAKGQRQARPDIEVLEKGKGKNILVFSLSLSRSLFYCLSSVSSTVSLFYLSISISISISVSSAPPTRLNHARLVNSTSQPDELASSVLSLSGLPQGLSVSLPWTDLGRPPSRRPPGDSTRLVLSSSSFLPLLFFFFTAWLACLLLLLLLLPFFLLLLACILVLARRPDSDSLFPLPSLHPSLSSSSSSSSLLLSTLYRLLSTLCCWLQLAMDNPPPSGSAGNSSDFVSLSLFSLSLLTDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M0</accession>
    <name>D4D9M0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022072.1">
        <property type="nucleotide sequence ID" value="XM_003022026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M0"/>
    <dbReference type="GeneID" id="9578956"/>
    <dbReference type="KEGG" id="tve:TRV_03813"/>
    <dbReference type="HOGENOM" id="CLU_029564_0_0_1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="38536" checksum="094FEBE7DAEDD45A" modified="2010-05-18" version="1">MYLPNTRWTWSFVIVTTIQAACVLAFESYVFARFQLQLKSDASTNTESKTIPTFLTLYIFGFVYELVLVYDALRLKNTIQVIGLCICNFGLLIYGAVQIDQIDTSVTQLGDLGLIHPEVIDEMRPFLIAIPCITALGTVGMSFLAWKLYDEFAWTIYKHISADLRMKRRYLTYQIYIALLKFDFFFFLGFTVQFVVIVTDTKTVEFALTLAAIPVTILILVMAAFWTRRESTVGMIIVILLYFGGFAYFLFKLIRMYSPAKEKAYLPARRSLTFFAVATIILIIMTIINAIMCTLNFNKGLKPHITSKKRPRGAEKEGTELHDQFSPHPVPTRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9T2</accession>
    <name>D4D9T2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022014.1">
        <property type="nucleotide sequence ID" value="XM_003021968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9T2"/>
    <dbReference type="GeneID" id="9578898"/>
    <dbReference type="KEGG" id="tve:TRV_03875"/>
    <dbReference type="HOGENOM" id="CLU_084507_0_0_1"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="9">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="209" mass="23239" checksum="97EB3E94963906C2" modified="2010-05-18" version="1">MDPSLNNLLKWSIENTPAANGQPNGTEQPAHRQPIDAEALQRLLANTPSDAELMKTAMEVVRSSETTLENQLIAFDNFEQLVENLDNANNMEPLGLWPPLVETLKDEEAEIRKMAAWCVGTAVQNNEKSQEKALEAKVIPELVRMAREDSDTTVRRKAVYAISSCVRNYQPALDQLREHLPAEIVGADEKIDAGDMDKIDAIIAHLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA01</accession>
    <name>D4DA01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glutaryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_03945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021915.1">
        <property type="nucleotide sequence ID" value="XM_003021869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA01"/>
    <dbReference type="GeneID" id="9578798"/>
    <dbReference type="KEGG" id="tve:TRV_03945"/>
    <dbReference type="HOGENOM" id="CLU_029285_0_0_1"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="12">
        <location>
            <begin position="280"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69539" checksum="AA4F8F051372CDB6" modified="2010-05-18" version="1">MNAALRRGTLRAALGAARRPADTAGPRRSAHSAAASFKWTDPLDAESLYTADELAIQDTARRYCQEQLAPRVLEAYRNEAYDPEILREMGSLGLLGATIQGYGCAGVSTVASGLITKEVERVDSGFRSGMSVQSSLIMTGIHEFGSEELKQRLLPQLAQGKLLGCFGLTEPNHGSDPGSMETVARPHPTKKGFFSLSGTKTWITNSPISDAFLVWAKLDGKIRGFVVERDQCPEGTLRTPAIKNKTALRASITGMIQMDNCPVPETNMFPEVTGLVGPFTCLNSARLGIAFGTMGALEDCISRAREYALERKQFKGNPLAKYQLVQKKLADAATDAAYGTLAAVQVARLKDEGKAVPEMISMIKRQNCDRALAGSRTLQEIFGGNAASDEYHIGRHVANLFVTQTYEGQSDIHSEFFTILLLIFTIIHANLLTIQTALYHIHFTIYHLHPPSTIFYQPSTVFIYSISLLFFYYLLLSSSLLYSTPIPIHLSAFTFSSLFLAFSSLSFSSPAKKHQQRRRTDLHDSPGFSRRYIKTSPCCLPRCQAASPSPSLVVPPLLAARRGKTRLSRNQLTPNPAIATEERKNSPPPERTRPRPPQVSLAPLPQTLHLQTAVMALKRINKELTDLGRSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAM7</accession>
    <name>D4DAM7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021717.1">
        <property type="nucleotide sequence ID" value="XM_003021671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAM7"/>
    <dbReference type="GeneID" id="9576800"/>
    <dbReference type="KEGG" id="tve:TRV_04175"/>
    <dbReference type="HOGENOM" id="CLU_048897_2_1_1"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="350" mass="38133" checksum="AEDDE3A36DDD9656" modified="2010-05-18" version="1">MVKLPETFAAIPRQEFLLGPSPIHLLPRMTADLGGQVKIYAKRDDVSSGLAYGGNKTRKLEYLAADAVGQGCDTLVSIGGIQSNHTRQVAAVAARMGLKCGLVQEKWVEWADPGYEKVGNIQLSYLMGADVRIEKMTSFGIEHKDTLKALTKEYEAKGQKPYYIPAGASDHPLGGLGFARWAFEVREQEQEQGVTFDYIFVCAVTGSTMAGIVAGFKLIEKLYPDEPRKKIIGIDGSATPEKTRAQVLRIARGTAEKIGLKADDITEADVVLDERYHAGTYGVPDKQTWEAIEYGAKMDAFITDPVYEGKSLAGLLGYVRNGEIKTGNILYAHLGGQLALNAYSQLGHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAQ8</accession>
    <name>D4DAQ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 transcription factor (Seb1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_04206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021695.1">
        <property type="nucleotide sequence ID" value="XM_003021649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAQ8"/>
    <dbReference type="GeneID" id="9576778"/>
    <dbReference type="KEGG" id="tve:TRV_04206"/>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000464">
        <property type="entry name" value="Zinc finger and SCAN domain containing 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="692" mass="75254" checksum="0A8A024CA85F2717" modified="2010-05-18" version="1">MIEEKEGMYVSASSDITNEISQAILSNILLTMDPACVAQQAQPSFYYYNPEPESRHGQHAFFTPHPNEYAQNQMMMVQPQMPQQFTQMQPQMHLHPSDQHNGAQFRTLGAKDYLSTPNAANSPSPSPQPMHIKPSVFLHGSPTLLSLDTNCGWADANGFPSTPPLSTSGSSISSPPSSCGMTNTPVGGDSFRMEGIEGVKEGCETDVELELLANSHWHRSASPEMTPLYVCPFSVHSNASLPSAEASHHNANSSTERGSSLTSSSSRSSSRSPIMTSSSSSSSLLHHETPTTSFSAQQPSSTDFCDPRQLTVDCPVLSLPVPDYPPLPPLSTVDEDRSRSTLLGGSLKPEQSLTVPGLSHDDSLESLSTFDAISDLDSEDEFVNGIVNFTPTENGFLLGEKRRRTVSNANNGTATTVSHEDDIISEQGLDDLEESDLFARSCIPLPEFDTAEQCNIAEDMRTKKRVSAVGRRIKQLPLGSEESDADSLGAIMRTAQSNVNNRASHTDSSSTQAQQQSGAPSHESSETNPQSTTSSETPAPTPMVPVGRRGRKQSLTEDPSKTFVCTLCSRRFRRQEHLKRHYRSLHTEDKPFECQDCGKKFSRSDNLAQHTRTHGGSGMPMTMSDHHPESSPFDDQDAGALGAVLYEVAQAAANKSTTSESSDSGLSTRDNQSAPFTNRKRPLKKRKREASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAW9</accession>
    <name>D4DAW9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021637.1">
        <property type="nucleotide sequence ID" value="XM_003021591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAW9"/>
    <dbReference type="GeneID" id="9578598"/>
    <dbReference type="KEGG" id="tve:TRV_04267"/>
    <dbReference type="HOGENOM" id="CLU_2656247_0_0_1"/>
    <dbReference type="OrthoDB" id="10277820at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="76" mass="8396" checksum="D671547E32B13F87" modified="2010-05-18" version="1">MEVLVWNSSSLHLIQRRQKLSRLAGLNMLIVTGCHEISMLATSLLNVENSSARKELGSSGKWLETDEITTSKPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB85</accession>
    <name>D4DB85_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021537.1">
        <property type="nucleotide sequence ID" value="XM_003021491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB85"/>
    <dbReference type="GeneID" id="9578498"/>
    <dbReference type="KEGG" id="tve:TRV_04384"/>
    <dbReference type="HOGENOM" id="CLU_014533_0_0_1"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="589" mass="61924" checksum="CCFECC5CC003285A" modified="2010-05-18" version="1">MAEKAEIEGAGGAPQPPPRESTPLGFRDAVKSREDAPKPSPETPQRASRPHLGLSLNMPQPFSPKSGHAAARIPLSPKLDSSHSFGSPASVLPRRSRGLDFSRACTNLHHSTLAESSPDSSPVVSGRGIAIPQRRGTAGSTGMGMAGSPSSSHHQLHNCLTSAGSHAERTAISSSVGSVNMIDSDSSSTDDEDDDGSIHGFDRGDPGGITPQAKKSGLGLSAPFSPSLIPASSADWMSGFSAAKASLMNFQRARYRNSKKRHSSSSASGASPRLLATSRSPPAEKALDSVGGSSLSQNLAPRDIKSKLDELAHIPSDFHLSDGSDDVDGGKQAGVSSPSSGSLAGGSNSESGRRGVIRRPVTRRGNLLPKPKNFARIRATLFEECAPVESDTKKEAEVVRQVRENDASGAPQPQSILPNALEIKDSTPPSLVPEEAHQRPPTSFSRQVSRNSSGIDFWNAFDGRYRTPPPLSARDTAMASPGMLKDIDTEPETFAKINKRRRGDDFDLASFKRRAVSPGPSVQSSPVQGHVSAGSDANRVGHLSKAILFQGSHPAEPTANTSSPSGPVKRVGLQGMTETSDGFMKMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB97</accession>
    <name>D4DB97_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase/esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021549.1">
        <property type="nucleotide sequence ID" value="XM_003021503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB97"/>
    <dbReference type="GeneID" id="9578510"/>
    <dbReference type="KEGG" id="tve:TRV_04396"/>
    <dbReference type="HOGENOM" id="CLU_004893_0_2_1"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="356"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="899" mass="98939" checksum="92C16501020443D6" modified="2010-05-18" version="1">MPFNILSVAFHASFTAVSTGVTHYLGKKPVKTEPAAHFSYHSGLEVVRRFLEHASRHTVEELQAFTGQKVPASYWVATGSVIIPAEHIESAAHILVAQLGPEGVSLVGGSRWWQWRDTEAALVAEWLETRRDYNDRRARNAKSNRIILYIHGGAYFFGTRFRLAPQFPFPCGLHDCLAAYLYLITIQKPEEIIIAGDSSGGGMVMSMLVTLRDQKFPLPAGAVLISPWVDLTHSFPSVAGTGVHDYIPICGFRHRPSTSWPPPSADEYGIESTTGEKILNKINSPPMVDKPSIADTKAIEDFYTSQACATAQSAHVEDYTTSELQESNGHRRNTQMLGEHLRVEIDGATIEIKDQIHLYTTNELISHPLVSPVLQPSLGGLPPLLVISGGGELLRDEQIYLAHKAANPEAYPPNDDILAKYDPDRKILSQYKPTYVQLQVWNNICHVAPTLSFTRPAKYMYRSVAQFSAWALSRAQESSIDIPDSSPTSSGDLLSNAEEKKASNKQTTEPELARHATIGKAGDPIPPFQNHMIRQLIDSEGHLLPLPDEHDLPALQVPRNHIGVPKPIPVRRWLAAKEEWDSKFVKEKRRVQKERLKRIPIGIDDIAPGDRPPPSSRAAQRGVTVSEVRQPTKKSIMLSFWNRLGAIHDAKVMEKEKKNNVENKFPTLWRGGVQDKQQAAADASLPSGQSKTQVVTDIGQSNESQRDFTTKPSRAIPEASVPQIWRSPSSEELGRTRSPRLNSESQGVVSDEGRGQKDESPVDSLLDEASIRTIRHSKGIISPPPSAAPLSDYQSVLEPGPYSGDKTTVGGPTQKNEGTSGESDEVTQDLPGEVVNRMNRNKLPMFDFESATGSNPRRELEPFSSSLNGSGGGARDNQSGYSSNYSQQSFSGPGNGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBD3</accession>
    <name>D4DBD3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04432</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021459.1">
        <property type="nucleotide sequence ID" value="XM_003021413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBD3"/>
    <dbReference type="GeneID" id="9578420"/>
    <dbReference type="KEGG" id="tve:TRV_04432"/>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="137"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="367"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="497" mass="54386" checksum="F8C0A067E9209413" modified="2010-05-18" version="1">MDGHLRPWLILLDDDDADLLVDSDGIARVHGMHNVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDVPVGPELLGRVVDALGNPIDGKGPIKSAEKRRAQVKAPGILPRKSVNQPVQTGMKCVDSMVPIGRGQRELIIGDRQTGKTAVALDTMLNQKRWNSSNDETKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFTGCAMGEWFRDNGRHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDTHKGGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKQTLNRGLRLTELLKQKQYQPMAVNEMVPLIFAGVNGLLDNIPVEKILAWEADFLAHLRSNEPEILAKIDKEGQISKDLEAQIRDCIVAFNKSFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH6</accession>
    <name>SED2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable tripeptidyl-peptidase SED2</fullName>
            <ecNumber>3.4.14.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Sedolisin-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SED2</name>
        <name type="ORF">TRV_04476</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10"/>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021402.1">
        <property type="nucleotide sequence ID" value="XM_003021356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH6"/>
    <dbReference type="SMR" id="D4DBH6"/>
    <dbReference type="GlyCosmos" id="D4DBH6">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9578281"/>
    <dbReference type="KEGG" id="tve:TRV_04476"/>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF32">
        <property type="entry name" value="TRIPEPTIDYL PEPTIDASE SED3 (AFU_ORTHOLOGUE AFUA_3G08930)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397831" description="Removed in mature form" evidence="1">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397832" description="Probable tripeptidyl-peptidase SED2">
        <location>
            <begin position="204"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53">
        <location>
            <begin position="210"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <sequence length="596" mass="64750" checksum="F1065580997B5ED2" modified="2010-05-18" version="1" precursor="true">MRLLKFVCLLASVAAAKPTPGASHKVIEHLDFVPEGWQMVGAADPAAIIDFWLAIERENPEKLYDTIYDVSTPGRAQYGKHLKREELDDLLRPRVETSESIISWLTNGGVNPQHIRDEGDWVKFSTNVKTAEKLMNTRFNVFKDNLNSVSKIRTLEYSVPVAISAHVQMIQPTTLFGRQKPQNSLILNPLTKDLESMSVEEFAASQCRSLVTTACLRELYGLGDRVTQARDDNRIGVSGFLEEYAQYRDLELFLSRFEPSAKGFNFSEGLIAGGKNTQGGPGSSTEANLDMQYVVGLSHKAKVTYYSTAGRGPLVPDLSQPSQASNNNEPYLEQLRYLVKLPKNQLPSVLTTSYGETEQSLPASYTKATCDLFAQLGTMGVSVIFSSGDTGPGSSCQTNDGKNATRFNPIYPASCPFVTSIGGTVGTGPERAVSFSSGGFSDRFPCPQYQDNAVKGYLKILGNQWSGLFDPNGRAFPDIAAQGSNYAVYDKGRMTGVSGTSASAPAMAAIIAQLNDFRLAKGSPVLGFLNPWIYSKGFSGFTDIVDGGSRGCTGYDIYSGLKAKKVPYASWNATKGWDPVTGFGTPNFQALTKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBI8</accession>
    <name>D4DBI8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021414.1">
        <property type="nucleotide sequence ID" value="XM_003021368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBI8"/>
    <dbReference type="GeneID" id="9578293"/>
    <dbReference type="KEGG" id="tve:TRV_04488"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_4_1"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25594" checksum="9746CC75B2321217" modified="2010-05-18" version="1">MLGSLTLYRRLLFEHVFANRELRAALPFVSPTVPDKLSTFGHGVAGILAGSTVSFVAAPVEHVKARLQIQYAADKKQRLYQGPIDCARKILRAHGLPGLYHGLCSTLIFRSFFFCFWGSYDIFSRAFRQYTDLSAPAINFWAGGLAAQVFWVTSYPSDVIKQRIVTDPLGGSLGDGERKFRRWRDAAVAVGREGGGWRAYWRGFLPCILRAFPANAMALVAFEGVMRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBJ6</accession>
    <name>D4DBJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021422.1">
        <property type="nucleotide sequence ID" value="XM_003021376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBJ6"/>
    <dbReference type="ESTHER" id="trivh-d4dbj6">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9578382"/>
    <dbReference type="KEGG" id="tve:TRV_04496"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="31979" checksum="6C45FAE729BF759C" modified="2010-05-18" version="1">MFSYLGNKITRWLGCGVKPKSISTGTDTPEATAIDSNSNLGKTKPVILIIHGAWQHPAYYQTFVQVLQSRGYETHCPRLPSCNGQVPPTKSLEDDVHFIRQFTAQLTNAGKLVDVIMHSYGGIVGTDALCKFGIAERSRRGFAGGVRNLIYLTSFVPHKGQSLVGIFEGQSLPTVKINEETNLISATDPIPMFYSDLPSEEAEYWVKQMVAHPYSAQSTPVSNEAFRELPTSYIVCENDKGILPEVQQMMIERLKVAGVDVQVKRCRGSHSPFLSMPNVTADIIENISNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK0</accession>
    <name>D4DBK0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021426.1">
        <property type="nucleotide sequence ID" value="XM_003021380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK0"/>
    <dbReference type="GeneID" id="9578386"/>
    <dbReference type="KEGG" id="tve:TRV_04500"/>
    <dbReference type="HOGENOM" id="CLU_037043_1_1_1"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="310" mass="34933" checksum="0F4EBE3F6FD53123" modified="2010-05-18" version="1">MVVGGCDLYTTKAASGDKKLYKNIETSLETQYESLLRLSASLSPPNASSAAMSLNLSRSSPFGPLSEHSSRRTYAYLIATLNASHPDYDFSHVLRPSDFRREKNLRRVMDTIDTTLFNLRPQLARDVTPPTPTSSSPHMSATTHSWGPRMWRIIDNQMSLKECSIYCYSPDEDPYDGEEGTIWSLNYFFFNKVRKRVCYIYLRGISVLSQLPADGTATPVPGKRNVEDDGYVSHDTGARKRAKYWFGDGANDEMDEFSADEEERQPSQPARPVVDEYDNYILSDDDLRSQSGSKPTVRALSEEIADSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBL7</accession>
    <name>D4DBL7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021362.1">
        <property type="nucleotide sequence ID" value="XM_003021316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBL7"/>
    <dbReference type="GeneID" id="9578242"/>
    <dbReference type="KEGG" id="tve:TRV_04517"/>
    <dbReference type="HOGENOM" id="CLU_020422_0_0_1"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="75231" checksum="879FA85DA6AD9C6B" modified="2010-05-18" version="1">MASELYYFKPSTPPRALMSDAELLGSAHSRTTSGSSEYASSSAYTDDSSPASRSTSVSTSSRSPGRRAPGPLLLPKIRPQDIVVEPQSHYGPQRSRKALSTTQNPPGFAPYPTSRPSISRRAVEPIDCSLVSPVCATPASYGYPGGSAMSPLSAVPPSSSRRRTSHSRNPSVSSIDDATLSRYGYPTYRQIPKYLSQYRPTTPASATSFTYPTPTYPTTPYTATAGDPLVSYPTSNYSTPAYPGTYPSPAYPTSAYSAGAEAYAPISEVASTQNHCGFSDTTARALGVSTVDPSFPPSLNVIPPSLAPPMDYSSSSSSASTTLLEYLNAPMQAINLVETMAYPSNRVSPAHFWWDVRNIRQWSSFSLEAMSAIPRFPQLLTTGVSQDCLPLSTVAPSRLYPDSEFSLTDLIRDVYAPRVNAALRISQGRDCLSLYPAPINPANRDNDPHFIANYASDTEQTPSGLPRGRIVGLVKTFNRWNTGMRNEAPHRRVEYLNGLSHLQRCMREHSCRYGFIMTEIELVCVRAGCDEGDDVPYFGFLELATPIATKTPYNPSLSSIGLSRSTSASSAQSSEYSTSSRGTSPFPTGFSGPFSATMALYYLLMLSKSVPLPTQPSWHLNVGGPGALTRQRTLPEDKDSWIPEPQQREKREAKRIRGWVWPHDAWHRREGGGSSRTRAAKIAAAKRWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBP5</accession>
    <name>D4DBP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021339.1">
        <property type="nucleotide sequence ID" value="XM_003021293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBP5"/>
    <dbReference type="GeneID" id="9578230"/>
    <dbReference type="KEGG" id="tve:TRV_04546"/>
    <dbReference type="HOGENOM" id="CLU_016397_1_0_1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="319"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="596" mass="65432" checksum="E41B81B2698928C6" modified="2010-05-18" version="1">MSADPHSQNDGATGSLGSNDGLPPTVATFSPTNISGNSLTSKQRSTIIVHRKSPLLVATPPAVTRALAYSHPFLLPLNRLAGLLSWTSGDPWESFLLVGAFWAVTLHGSAIILWGGPILVVVALMLGLYSRRYSPLSSTGLTGEKHRREGSDGSSRPHKTLDEIVETLREFTTRCNILLEPLRDLTDFLSTQRTATSTTTRPALTALLTRIILITPIWILLTLHPIYLITIKRVVITVGTIILTWHSKPARIFRVLLWRSLTIRRICSTITGLQFSSLQHSGDQSSNSFTKSSLLSLTAFRSKQPSQHGSTKRRANSSGVRFTFIVYENQRRWLGIGWTYSLFAYERPAWSDEHLNPVPPKDEFELPEVQGSNSKWRWVEGSEWRIDGSSDPSAKKKGKGGKNNDNKDDGGWIYYDNKVFNFHLQLVEISPDGETIETPSKTAADNESKSKGDSGKDSNSGDDKNSIKARKRRWFGSTDLKGFSAVEPEPSSSTQPINAESTSASLSMVGSSLPKALSVSSGRSSNNTNGSIRARSKRPASIHTDGDRKSQTSSIRDREIEEAENMPDKWGSQSGNAAERAGRGWGLGDDAHMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBX3</accession>
    <name>D4DBX3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000233">
        <property type="protein sequence ID" value="EFE40655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021273.1">
        <property type="nucleotide sequence ID" value="XM_003021227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBX3"/>
    <dbReference type="GeneID" id="9578118"/>
    <dbReference type="KEGG" id="tve:TRV_04624"/>
    <dbReference type="HOGENOM" id="CLU_395924_0_0_1"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="651" mass="73151" checksum="279BC738B885F4BD" modified="2010-05-18" version="1">MESSSLKYTRDTGSPLHPLSPRRINQQTMNRASPVPSDLAYLQSKSDRHSVDVQSKVAFLNRLASPSSPAPLPSSSTTHAALQRAILGREEAEEALKATTEELNEARQRERRVSERLESLLEELHTFKERQSQERTLFEKEIRRARKEAFRAGSNLVKAQEELKSSRGEIKNLKDEVKAEREAKDKARQEAFERAYALAGLTEKNEVLKEQIRAFETDNQSDILEAQAEMMRGETPRSRVQRSSINLMSGSPALRGKKRGQPDSRDQMSPVRKKSAQHQPDFRSSLKSPTKLTPGRDMVPFEQEDEPLKLMDNEREITLELEEDLRWEKLMRRRAEDMIDFLKLECQFKRCSCRIAERQGVKYVHDLGWEKISPAENQEKKAVANIPSPPPARKPSPQLQIAQRSPTPEGDNVDCPEPDPASDEAPVEPDVVFCPDTGTFKTVPSPVRKTETMRREQPNIRPPVNNADPPPKLRRSLHDDPIPTPSLGEPKKRTQEPLPVAALEASHHQPPSSRSHIQEQPADTNSRKRYVTPLPLEQRQRQNNTTVEVETITTTKTVPLNSEKPSADLSAKLPGTPISREEALAQIRARRGRTQSALKRSASANDASHRPRVVSGASTPRNGVRSLSRAEGTINRAKPGRRGLSAAGHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC93</accession>
    <name>D4DC93_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-dependent flavin oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021131.1">
        <property type="nucleotide sequence ID" value="XM_003021085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC93"/>
    <dbReference type="GeneID" id="9577973"/>
    <dbReference type="KEGG" id="tve:TRV_04745"/>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="46328" checksum="1B5C6CE0DDFCB1AF" modified="2010-05-18" version="1">MGDSDIDIKNISNTPAPGISYFTPYQSPPAGQAANPQSNGSAPPKLFQPLKIRGLTLHNRIGLAPLCQYSSPDGHLTDWHMAHLGSIAIHGAGFVMVEATSVLPEGRITPEDSGLWKDSQIEPLRRVVEFVHSQSQVIGIQLGHAGRKASTFAPWLSSGDLARENVGGWPDNIKGPSDIPWGPRLGKPKAMTKADIEEFKEAFGASVRRAVTAGVDFIEIHNAHGYLLSSFLSPTSNNRTDEYGGSFENRMRLTNEIVDICRKNMPEDMPLFLRVSSTEWLEESRPDLPSWTVEDTVRFAEVLAEGGKVDFIDISSGGNHPDQKVRGALPGVPYHAPMAKAVKKAVGDRMLVGVVGNITTGTTANRLLEEDGLDYALVGRWFQKHPSLVWSFAEELGVDHKVANQMSWPFGGRGSTTYLKAAQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCN1</accession>
    <name>D4DCN1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021021.1">
        <property type="nucleotide sequence ID" value="XM_003020975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCN1"/>
    <dbReference type="GeneID" id="9576668"/>
    <dbReference type="KEGG" id="tve:TRV_04886"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_7_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="28696" checksum="D7D13ACD0375B9D6" modified="2010-05-18" version="1">MLDSFIRHGVKGDALRSEVLDALVIGSFGPCYSICSVILHTLANQSVLTKLRCEINEAVATGKAPRTGEGLISFAQAKQLPYLQAVIRESQRLLPPVIGLFPRDIPAGGDFVTVASKTIFLPGGAYIGRSVYSMFHCKETYGQDADKFRPERWFEAEDAKLANMIRVNELIFNHGKYQCMGKVIAQAEIAKAVFEVSAEIVSRHRHIANIVDEQLLREFDFDVVSQDKDPWKTVDMFGICGVSDFWVHVKSVEGKTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCN7</accession>
    <name>D4DCN7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021027.1">
        <property type="nucleotide sequence ID" value="XM_003020981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCN7"/>
    <dbReference type="GeneID" id="9576674"/>
    <dbReference type="KEGG" id="tve:TRV_04892"/>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="230"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="440"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="504"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="517" mass="56351" checksum="3149732D25ABC61B" modified="2010-05-18" version="1">MDLAACYPPELSSEQKQHLVATIKDWCIHHGLAVRPPPAFVQGTSDPQGVLATNAPVTLFPSLFPRSCYEAAVSVQETYNQLYASITTDTDWLGEIIEDLVEVDDFVAGLWKVHLAVKNEGYVQPLSLGLFRSDYMVHDPSGSSKEPVLKQVEFNTIAASFGGLSGLVSQMHTSLLSSPTGQPIVYPSHPAFRGNIPPENTAVPTLAGGLAAAHKAYGPSKSSPNPLPLCVLFIVQAGERNLFDQMELATCLSQSHNITVFRVTSDEILELTSIQESNPARPIIYTPRYSPSTQFEATTIYLRALYGPQDYPDESAWKARTHLERSTAIKCPTVLNQLSGCKKVQQILATAVSGPEMDYLTRFLPCTNPGRIQQIRSTFAPQYDLAEGGRGRELALNPETAAFHVLKPQREGGGNNVYRDSIPSFLKSIPEKDWKGWILMELIQPPPAKNVALRSDGQVLSGDVIGELGTYGTILWNTNGETLHNTQGGWLMRTKAKDSDEGGVAAGFSSLDSILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD81</accession>
    <name>D4DD81_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020812.1">
        <property type="nucleotide sequence ID" value="XM_003020766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD81"/>
    <dbReference type="GeneID" id="9577563"/>
    <dbReference type="KEGG" id="tve:TRV_05088"/>
    <dbReference type="HOGENOM" id="CLU_039465_0_1_1"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="422" mass="48143" checksum="8D4FF22321D1B145" modified="2010-05-18" version="1">MANEEPKAGDINPGRLLADSKAYRRKRAEIVKASRKRDVRLLAKLATSEGGLLEDDIRKQVCKIGACSVFFAFFADGLTKCFLPGPILQGYVRATHTLELPPLSELPCHGDEDQVKLDVDRSFVYYPNYKTEKHLKDKRDELLDLIVSVLRRNPMLCYFQGYHDIAQVLLLVLDRKHAYQALEHISLFRIRDYMLPSLSPALTHLQLLPAIITSVDQKLGQHLSGTKPFFALAATLTLYAHDIEEYAHIARLYDFILAHEPVVSIYLFATIILSRKDELYDIPQDEPEMFHGVLSKLPRPLDLETLISNTVRIYQDHPPEKLPCGAWKSIPSYSVLKTLRNPGLHSTPDQARGYFHQQIRGLQREKMRKDAALLIRKHSFSIKLVGATVAVGILSYWMIKRDPDLVKHLWRYLGPLKTTMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDB9</accession>
    <name>D4DDB9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000261">
        <property type="protein sequence ID" value="EFE40155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020773.1">
        <property type="nucleotide sequence ID" value="XM_003020727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDB9"/>
    <dbReference type="GeneID" id="9577472"/>
    <dbReference type="KEGG" id="tve:TRV_05128"/>
    <dbReference type="HOGENOM" id="CLU_055690_0_0_1"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="204"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="32360" checksum="575AB49E6DC382DD" modified="2010-05-18" version="1">MIPALRQKKTQNRRNFIETPTSTSRPARPSKPPPPPPDRPTSACKSTGCAQLLVSRLAMSPLAASSASSLRACARHASVVPRALAASSIAQQRRGGASDASASASFDSPFAKSSGSSSTYKIPSFGKYASPRRESTNKTFSYFVVGSMGMMTAVGAKATVQDFLLNMSASADVLAQAKVEIALNSIPEGKNVIIKWRGKPVFIRHRTASEIQEAQETKWENLRDPQPDSDRVKNPEWLIMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEVPIYDFPSDDTLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDS7</accession>
    <name>D4DDS7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020612.1">
        <property type="nucleotide sequence ID" value="XM_003020566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDS7"/>
    <dbReference type="GeneID" id="9577311"/>
    <dbReference type="KEGG" id="tve:TRV_05289"/>
    <dbReference type="HOGENOM" id="CLU_043294_0_0_1"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="42922" checksum="EC1969B78FDB26E1" modified="2010-05-18" version="1">MAREFTPDSEFAALETPRVPNKLQSLTALGRFEFEAGKGNEGTKILMVEWEDDDLSRSSTGSWQVSWDGKQTVLPAHDQATDQIRRCYFMLPPHATIPPTVTLTYEPPPSSASTVKKSESIQIHPLPAIYPPELGATARTAGKKGVLHTIWAKKRLQVLEKEIKEESQYNAEGIALHMAIEEKEWIEANFGVVVKGLPPLVTTNVLSNLNAPLSPTTPVSPTGGNRLAEKLKGLRLGTSEKDLTRKPMGNSGSDPQLHPLSPDEPDMAISSFSSFHTGNTPVNASTPSLQTLQQSQPSNLSSQPQTHPIGRQPVAHAPPDFIRRQQEQDSGFASLNMQPIGDNGVLNNEVNTASAADVQDGLFAKALSPRSPDIPKSPFSFSTEETLPYAKQLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDT4</accession>
    <name>D4DDT4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE40001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020619.1">
        <property type="nucleotide sequence ID" value="XM_003020573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDT4"/>
    <dbReference type="GeneID" id="9577318"/>
    <dbReference type="KEGG" id="tve:TRV_05296"/>
    <dbReference type="HOGENOM" id="CLU_2170450_0_0_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="110" mass="12135" checksum="9B0ED148B9B92B45" modified="2010-05-18" version="1">MEARYCLEADGGRTEAAAAIGLGSANISTPIHRMPMATTMGAAAGIFAIFFLGDVPRIREDILMNIPVIGSYWDRSIAPEDNVRLFPIPWPLLILTFTLFLFDADDLMFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE65</accession>
    <name>MAP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2</fullName>
            <shortName evidence="1">MAP 2</shortName>
            <shortName evidence="1">MetAP 2</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TRV_05431</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EFE39847" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39847.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020465.1">
        <property type="nucleotide sequence ID" value="XM_003020419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE65"/>
    <dbReference type="SMR" id="D4DE65"/>
    <dbReference type="MEROPS" id="M24.A02"/>
    <dbReference type="GeneID" id="9584204"/>
    <dbReference type="KEGG" id="tve:TRV_05431"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407670" description="Methionine aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="449" mass="49232" checksum="7CB3434189AF910B" modified="2011-05-03" version="2">MAAQAAPELAKLDLNKNTGSVEANAVSAGGSEKEEAENEGDSEDDRDDEQAGGSAEVNAEKKKKKKRPKKKKKTAKVQSSPPRIPLTTLFPNNNFPEGEIVEYLNENSYRTTNEEKRHLDRMNNDFLTEYRQAAEIHRQVRQYAQKELIKPGATLTDIAEGIEDGVRHLTGHMGLEEGDSLVAGMGFPTGLNINHCAAHYSPNAGNKVVLQHGDVMKVDFGVHINGRIVDSAFTVAFDPVFDPLLTAVKEATNTGIKEAGIDVRMSDIGAAIQETMESYELELNGTSYPIKAIRNLNGHTIGQYEIHGGVNGKSVPIVKGGDQTKMEEGETYAIETFGSTGKGYVRDDMETSHYAKVPNAPSVPLRLSSAKNLYSLINKNFGTLPFCRRYLDRLGQEKYLLGLNNLVSSGLVDAYPPLCDVKGSYTAQFEHTILLRPNVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEK1</accession>
    <name>D4DEK1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000298">
        <property type="protein sequence ID" value="EFE39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020343.1">
        <property type="nucleotide sequence ID" value="XM_003020297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEK1"/>
    <dbReference type="GeneID" id="9584082"/>
    <dbReference type="KEGG" id="tve:TRV_05568"/>
    <dbReference type="HOGENOM" id="CLU_2591512_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="80" mass="9776" checksum="D568E94DD6BBD4D9" modified="2010-05-18" version="1">MLVGESKGYRKEEDIYKEREREKVEEEEEGWKKWRSKGRERALSTFFLAGEEGKRTPPRGEAEERKKKKKKMMMMMMMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEM0</accession>
    <name>D4DEM0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC multidrug transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020313.1">
        <property type="nucleotide sequence ID" value="XM_003020267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEM0"/>
    <dbReference type="GeneID" id="9584052"/>
    <dbReference type="KEGG" id="tve:TRV_05587"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="64"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="389"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="707"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1275" mass="138358" checksum="12E4C3C398BD996A" modified="2010-05-18" version="1">MSGNDVVYGDEVAHHEPGQEKKPLVILSDSEKEVVELQLNGLPTAIDAQSLWSYTTDWDKTIIIVSVAAAILGGASNPLLTVVYGLAVGSFADRSNGVTSIPELSAAVAKVCLYWVYLGIAMFFFIYITTVGFYYVGERIVMRLRYAYLRTILRQNIAFFDTLGAGDVTTRITSDMNLIQEGITSKVSMGLIAVATFCSAYTITYIQYWKLGLIMTSTVVVMLLTGTAGGILAVKNSKSSMTLYNSGSNLAEESIGSIKHVTAFGIQNALADKYLSFLRQGEKPGIKARLAISFMISFMNGLPFLSYGLCFWQSGRYIISGHMGPGAAVTATMAIVIGGFSIGRVAPSLQSFMSSTASASMIIRSMQRASPEDPLSTEGERPEGIKGEVSFNDVSLVYPSRQDVAVLKCVCLTMPAGKTTAIVGPTGSGKSSIVGLVERFYRPTRGHITLDGHNIQDLNLRWLRSQLAYVGQEPILFNTTIQENIGHGLAYLDDAARSSRDLKAAVIEAAKDANVHDFIMALPKGYETVVGEKGLQLSGGQRQRIAIARALIRDPTVLILDEATSALDSRAEKLVQKALTKAAKGRTTIVIAHRLSTIRSADNIVVLSAGEIVEQGDHDSLMANQGLYANLVNGQQLTEEKTDEDDDALIENASASSWFVDEKSTAKELPEIVVEKTDSKKLDKRLSFWDLLRLMDKLNRPERMLILLGLIGCVFAGLGTPVQAIFFAKLIEAVSVPASQYNKLRSETSFWALMYLMLGIVAIISWFGQGACFAFSSERLIRRAKDTTFRSILRQKVSFFDERSTGDLTTILSQDTTHLGGLDGAVLGSMITFTVTIIGGLALSVAIGWKLGLVCAALIPITVGSGYVRLIILSLFDRKVRQTQAESAAYANEAVRAIRTVASLGLENEVLQRYRAILERDAAASLRSILQASVLFALSQSLLMPTGALVFWYSSTLLATGEYTLTQCFICFSALVTGAQTAGAVFNFAPDMSKAMQAGRHLRNLFERVPPIDSYSTEGRLLPAEACRGAIEIQDVSYRYPQRPERVVLENFSLSIKPGQFVALVGPSGCGKSTVLSLLERFFDPETGQIQVDGSSVTGLNISQYRSCIAMVGQEPVVYSGTIRENLVLGAAEGVTDEAIVQACRDANIYEFISSLPDGFATVVGAQGSMLSGGQKQRVAIARALLRNPKILLLDEATSALDSQSERIVQEALDRAAKGRTTISVAHRLSTIKRADLICVMDQGKLVEKGTHEQLMARREMYYDLVQAQNLDTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEM4</accession>
    <name>D4DEM4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020317.1">
        <property type="nucleotide sequence ID" value="XM_003020271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEM4"/>
    <dbReference type="GeneID" id="9584056"/>
    <dbReference type="KEGG" id="tve:TRV_05593"/>
    <dbReference type="HOGENOM" id="CLU_034744_0_0_1"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="320"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="555" mass="62514" checksum="EE2A536142451ACF" modified="2010-05-18" version="1">MFEKYQPPRSYGSSGGALSLTGLESMSAAEKTARIMAVANDMAASIIYIAKQAEAGNLTNRQIIPIYNFIDSILGLERSQTKSLMRELDKQGSRIALMEKQHSRDIEELTKCAMETITQMKVRIAQLEKNSTKRWKQKEEEELVGDKETLLGGAQEVRRQLGIARRWLARRGRGEEFYLGISSGRRPQKEKRSRGRQRQRRWNQVEIILFQSTPYLSSVSAVSVSDQHSSFIQRSCASIFHTADSMSSKGDFAAVRRDIAAQMKQPGYDDGSAGPVFVRLAWHSAGTYDIESDTGGSNGAGMRYEAEGGDPANAGLQHGRAFLEPIKAKHPWITYSDLWTLAGVVAIKEMGGPEISWLPGRTDFVDDSKVPPRGRLPDATKGSDHIRHIFYRMGFNDQEIVALSGAHNLGRTHMDRSGFEGPWVNNPTRFSNQYFRLLKKLEWKPRTLSNGTKQFNYVDEDVPEEEREEPLMMLPTDMALLSDPEFAMWVDKYAEDKELFFDHFSKAFHKLMELGIKRNAQGEVINTDNVRGGYISAPKKSDRPTAPDQAPRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF12</accession>
    <name>D4DF12_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000322">
        <property type="protein sequence ID" value="EFE39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020178.1">
        <property type="nucleotide sequence ID" value="XM_003020132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF12"/>
    <dbReference type="GeneID" id="9583948"/>
    <dbReference type="KEGG" id="tve:TRV_05753"/>
    <dbReference type="HOGENOM" id="CLU_2252017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="104" mass="12343" checksum="B7741CD8CF7FCB58" modified="2010-05-18" version="1">MQKKRREEKRRAISRKDEWNDYGKAERTKNEDTSRQAIRITRQTDKAKHADFIFLVSYLLLVGSFAAKEKEGKGTKEREKLGVWKRESDNGKNERKYEYMGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF29</accession>
    <name>D4DF29_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000327">
        <property type="protein sequence ID" value="EFE39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020166.1">
        <property type="nucleotide sequence ID" value="XM_003020120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF29"/>
    <dbReference type="GeneID" id="9583934"/>
    <dbReference type="KEGG" id="tve:TRV_05774"/>
    <dbReference type="HOGENOM" id="CLU_015740_4_2_1"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="14">
        <location>
            <begin position="325"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="485" mass="53810" checksum="6023B7C30786CCC7" modified="2010-05-18" version="1">MVPVQKWWQVPYFWAGTKCYDFLAGSEGIESSYFLPRSKALDAFPMLRKDNLFGALVYYDGAHNDSRMNVSLAMTAALYGCTVVNHMEVTGLTKDANGKLNGAKVKDLIAERNGEKDGEFTIKAKSIINATGPFTDSIRKLDDPSINEIVAPSSGVHIILPGYYSPAKMGLIDPSTSDGRVIFFLPWQGNTIAGTTDSPTEITKDPIPSEEDINWILSEIRGYLAPDINVQRDDVLAAWSGIRPLVRDPKAKNTESLVRNHLISVSNSGLLTCAGGKWTTYRQMAEEAVDEAIKQVNLRPGKPLATPNTSGVLSYSDNAVLDGTCQTHRVRLMGAHGYSKTLFINLIQHFGLATDVAKHLTQSYGDRAWEVAALSNPTDMRFPLRGVRLSPLYPFIDGEVRYAVRREYAQTAVDVLARRTRLAFLNAQAALETLPLVIDLMAEELKWDAKRKQTEWDDSVRFLMSMGLDKRRLGISRKDVEAGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFC9</accession>
    <name>D4DFC9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020102.1">
        <property type="nucleotide sequence ID" value="XM_003020056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFC9"/>
    <dbReference type="GeneID" id="9583866"/>
    <dbReference type="KEGG" id="tve:TRV_05875"/>
    <dbReference type="HOGENOM" id="CLU_533388_0_0_1"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="56661" checksum="324FAC6B0D93FD77" modified="2010-05-18" version="1">MSSTAVVGDDDVLEPTLQCLLDHKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGYDNLSAMEIDPNGSIQDLMASGGGDGNDDAMGGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALSKLSQLSGQFGPMLNSVLGARGGLPGGQNLDDVLSKMESLRETIAEVNSQFKDADMTTFVCVCIAEFLSLYETERMIQELTSYNIDTHCIVVNQLLFPGKDNACQQCGARRKMQKKYLNEIKELYEDFNVVRMPLLVEEVRGREKLEKKFTGKENYTGLVVIEEGVISPLKKERERRNNYKPNQVKRVIRLIFTMVDYDALLKGPWMELEERMEAQGHIHKYIRPAQNKLDPSTHNVNPQTVERQRIDNSMKLLRIIALSPSYQDPAGGHLLEIPKSGTCLAFVVNMDNGWPAMEHRVVSLSSFSHKSTATVPSKRTRTLGSIRSLLRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFP2</accession>
    <name>D4DFP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019947.1">
        <property type="nucleotide sequence ID" value="XM_003019901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFP2"/>
    <dbReference type="GeneID" id="9584699"/>
    <dbReference type="KEGG" id="tve:TRV_05993"/>
    <dbReference type="HOGENOM" id="CLU_094004_4_1_1"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="17077" checksum="C9D04F5833BD60E8" modified="2010-05-18" version="1">MASGVTINPECIEAFEKLRLGKGAGRTKYIIFKISDNKKEVVVDEVSTNDDYEVFREKLANCKDSMGRPAPRYAAYDVEFQLEAGEGWRQKIVFISWVPAETPVLWSMIYATTRQTLKETLHPHVSIQADDPSEIEWAHVLAEAGGKNATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFP4</accession>
    <name>D4DFP4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019949.1">
        <property type="nucleotide sequence ID" value="XM_003019903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFP4"/>
    <dbReference type="GeneID" id="9584701"/>
    <dbReference type="KEGG" id="tve:TRV_05995"/>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="216"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="710" mass="81352" checksum="203F1E681FEC3492" modified="2010-05-18" version="1">MKSERYTQYTSQPQTMAAKVPDGTGVVDLDPWLEPFKDALRSRYKRATDWIRKIDETEGGLDKFSKMLSHAQGYEKFGFNVASNGDITYREWAPNATTAHLIGDFNKWDPTATPLKKNDFGVWEGILPAKNGELAIPHNSKVKKHQITMTTPSGERLDRIPAWTKRVTQDLSVSPVYDNVFWHPPKEEQYQFKHAAPPKPKSLRIYEAHVGISSPKTEVATYKNFTEVMLPRIKYLGYNAIQLMAIMEHAYYASFGYQVNNFFAASSRYGIPEDLKELIDTAHSMGIVVLLDVVHSHASKNVLDGLNMFDGTDHLYFHSGGKGNHDLWDSRLFNYGNHEVLRFLLSNLRFWMEEYRFDGFRFDGVTSMLYIHHGIGTGFSGGYHEYFGSSVDDEGVAYLALANEMLHKLYPNCITVAEDVSGMPALCLPLVLGGVGFDYRLAMAVPDMYIKLLKEKKDEEWDMANIAFTLTNRRHGEKAIAYAESHDQALVGDKTLMMWLCDNEMYTNMSVLTELTPLIERGMSLHKMIRLVTHGLGGEGYLNFEGNEFGHPEWLDFPRQGNNNSFWYARRQLNLTEDHLLRYKFLNEFDRKMQLTEEIYGWLQSPQAYISLKNEQDKVLVFERAGLLWVFNFHPTNSFTAYRVGVEQAGTYRIVIDTDDSDFGGFDRNAKGTRFFTTDLEWNGRKNYTELYLPTRTALVSSKFSPFDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG23</accession>
    <name>D4DG23_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019837.1">
        <property type="nucleotide sequence ID" value="XM_003019791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG23"/>
    <dbReference type="GeneID" id="9584588"/>
    <dbReference type="KEGG" id="tve:TRV_06125"/>
    <dbReference type="HOGENOM" id="CLU_024893_0_0_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056251" evidence="3">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="29200" checksum="BDE6EE05747361EA" modified="2010-05-18" version="1">MKLYTPKAVMAVAFLLSSSLSCVEAKLDESLKGCYKGSGSLKDMGPTKYQSTGACRELCTQSQSAVFALHDTDRCSCGDKYPPDNLKAAATDKTCVLVNCPGFDKDKCGGKNSFAVYLTGLVDDPATEGGADDGDATKTSSTPQATITEGGHTIIITPSSKPAPSGPNKAGIAAGVVVGVVAIGAIIGGVIFFLKYRKRQKVVDEYRRNQTINNFVAGGKPSYSQSSADSRLDPSMTSQRRQSNGSIADDQDFSRRVLKVHTIIHLSPTCLRFPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH33</accession>
    <name>D4DH33_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06488</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000369">
        <property type="protein sequence ID" value="EFE38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019489.1">
        <property type="nucleotide sequence ID" value="XM_003019443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH33"/>
    <dbReference type="GeneID" id="9577935"/>
    <dbReference type="KEGG" id="tve:TRV_06488"/>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="506"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="783"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1118" mass="119866" checksum="03123376C8BEB8EA" modified="2010-05-18" version="1" fragment="single">LKRVTEDDTEDTSNDMFYSAGEEKGLEEGTDEGTDAESPSPPGESDTEASTESRSEAEGSEDSDDSDDSLEDMISLAAPELPQQQSGAMSAFSSATPRLGGRSLGIHSPGSVFSSFTSNTARQGRHSGKTFKAECLLDHIPNELLHPKPREEDDPDAFIFVDVHTLVKIGCFSGDWVRVAPTEEPQRNMLSSLASSGLNGLMGSTEEPENWRVARVYGVTGLSPPKIRYAMNKSAERSSSISQIPPHGLTPTVLLPPLLLHNLQSPSYVKLSPLSLGPAQHGPSKLGLAASRGSSVPKAPPTAKEVTLLKISTPLSLDRALQPAIFAALKHHFESKRRLVKAGDMIGISIDEGLGRTVFSATKSADAVGQEDELPSQLALSSGKPSHSSKVGVAWFRVSHVTAPMTSTEPDGAPDHELWGGVAAIDTLNTRMVQAGSEIGTVPGTLKNTWEYWLSVKSAPQPSIEQSATPWLQADSPAVFISPIQRRVRELIAAATSPRAIQLGLKPVVILLTSTQRNIGKSTVARRACADIGLHTFTIDSYDILSEGGANGGDMKTEAYLKARADRAFACGSACTALLIEHIEVLTADRIVTSLKEIVSSSRVVIATTTDVEKVPEGIRSLFTHELEMTAPEEKEREGILRNAVADLALRLSPNVDLASVAVKTAALVAGDLVDVVERAVAERTLRLEKLADSAAPPDAKSNVSVRDVQIAGGDATRSVTKADFDAAVDAARKNFADSIGAPKIPNVTWDDVGGLSNVKDAVMETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEFSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSGGDENGGGVFVIGATNRPDLLDAALLRPGRFDKMLYLGVSDTHDKQLTILEALTRKFNLHPDLSLKRVAELLPFTYTGADLYALCSDAMLKAITRQATAVDERIKALPNGPVTTAYFFDHLATPEDTAVMVTEQDFIEAKNELVPSVSAKELEHFERVRKTFETVDSKKSSLSNEQKAIEDVSRDGVDITADGSLTIGEALNASNKPTGDAKDTGEDDDYIVRTDHLASTESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHA6</accession>
    <name>D4DHA6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019395.1">
        <property type="nucleotide sequence ID" value="XM_003019349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHA6"/>
    <dbReference type="GeneID" id="9580111"/>
    <dbReference type="KEGG" id="tve:TRV_06562"/>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="405" mass="45449" checksum="B42EC72015B651DF" modified="2010-05-18" version="1">MQQQMAAEAQRRGMTVEEFGKMQREQIAAEAARQGLTTEQFIHRLKAQALRQHQMQQQQQQQQQQQQQQQQGEGQPGQQGQHQHQHQHSQQQQQQHQVPVNSNAPPDPKGIAVAQFLRSQNLKPRVCILDGRRKELFKVKRALRALQSPAYAKASAKPKSNLPPVTDLASAENAFRLLPMSLLALKVTKIDPHEGHNHAKPPSKKGRVKGLWTVRIQQHQDTDPMSHYVWLYEGPQWKQKAMAAGVLAAIMAVVMFPLWPIMLRQGVWYLSVGMMGLLCLFFAMAIFRLILFAVTFFVASPGLWLFPNLFEDVGFFESFVPVWGWQETKKKKRSKKTDGSSSKPSKPKSSKSTAAPPTTTEKAPAADQPVTAPDVSNEKANQTKSSEQSPGKQAFAASVEDAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB5</accession>
    <name>D4DHB5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019404.1">
        <property type="nucleotide sequence ID" value="XM_003019358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB5"/>
    <dbReference type="GeneID" id="9580120"/>
    <dbReference type="KEGG" id="tve:TRV_06571"/>
    <dbReference type="HOGENOM" id="CLU_003590_1_0_1"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="271"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="506"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="837" mass="93991" checksum="43670EA5FA30EF0D" modified="2010-05-18" version="1">MSGSFHMREHVKSFDFMTKESHFKGFCAQDGKLEAEVEPAAILELVRRYVEVMIDHVLGRPSTQFRKIQVFAVVAFWLLYLLKGNKNGPPGVRTLSSLLHRRMTPWQATVMTMLTLYVSRNFAKLVGLESPEPLANLYSRSYFRATWIVTALDAGFWTAMNIRRKWLRDLASLVFSIYYLFAAEQADEKVRKVRATLTVEHLRVSWNKLATPYLSFLSRLLRPRFCRRDPVAIRIPRPRESSYKDPVDAWLYFDGPLSSLRDQTDIVLDIPGGGFVAMGPRVSDDRLLAWAGKTGVPILSLDYKKAPEYPYPYALNECYDVYHTIVMSRGRCLGLSGKTCPRIIVTGDSAGGSLAAGLTLMILQSGSTDSRKWRGEYCLPVPVGLVLVYPNLDLNIGSWMTDEELSLIRERGMRKTNRNILRRKSEDYYKLTPSTPRPSDDDLADDTTSHSKSSTKEGSKHISDVPVGSSTVATDMACQSGDASLASKMEGLAEKKPKKLQTRLAVTSMISYVNDRILTPEMMRAMIILYIGPYNRPDFSTDFLLSPMLAPEALLAQFPKTYFMTGERDPLVDDTVIFAGRLRQAKLHRFRERKELGLEKPGKRFDEKEHVEVTLIPGISHGFMSIVGVFPEGWKHVFRTARWVTDIFNSTDPSSSDEAREFKASLPQQRRVMPSLNPSLPTVDVETGKQSDGSTRHRHHERHLTSESSGDEDGPLEISMLKMTKISPSPPASQSNFGASATSPLKLKAPAPKRNIRRPNAAKLSLTPLPAKKEEILRSSDDVSHSENDLVRMRQMISGLRREASLTSLPSHEDLLNRRMDGLAGGLMGIGEEAKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHD6</accession>
    <name>D4DHD6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000378">
        <property type="protein sequence ID" value="EFE38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019389.1">
        <property type="nucleotide sequence ID" value="XM_003019343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHD6"/>
    <dbReference type="GeneID" id="9580104"/>
    <dbReference type="KEGG" id="tve:TRV_06592"/>
    <dbReference type="HOGENOM" id="CLU_010412_7_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000003">
        <property type="entry name" value="Polyubiquitin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="49274" checksum="DE7F4C50A64852D2" modified="2010-05-18" version="1" fragment="single">TSITMQIFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGETTTNTISQPVVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLWMGVRTLLGNDLFFLTSWDEMRFFFTTFNYTGFFLMALGERMMMLLPKLSCSTDSGTGTFVLVELALEEDGYEGWLSVLQISNTSSEHSNHSTLPPIYITLFNSLTLKINIQHPNDLPAPCPSGVLCSLDMQSFGRNEYTLSQSRQQHPPWLALLVQLADTPPSQVYKEAVNSHLPSFSFSLSSLSQDISKNQESEIIYIVLKAHIEAKLCVRNPFQKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHH1</accession>
    <name>D4DHH1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019346.1">
        <property type="nucleotide sequence ID" value="XM_003019300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577668"/>
    <dbReference type="KEGG" id="tve:TRV_06627"/>
    <dbReference type="HOGENOM" id="CLU_002517_0_0_1"/>
    <dbReference type="OrthoDB" id="5416983at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1331" mass="142875" checksum="1EFF20A7395DB644" modified="2010-05-18" version="1">MAEQSSNDVVNQTRSGGDLSPSDVPASKPDNLTAGGDRGDVQASDNNSKPKANTQSSQEISTGNPSSTEANGVGSESNDANTSLSPNVGDGSGGSDTDASRPDARSNTDGAQHSRTSSVKRPASFKPVSFAKFSVTKPPGSNGNSKASPEKVAKSGSGLRDSSPRTSTAGSKNVSGAPDANLVWNKNRPVQPPPTKHLTDEELKQQYGIHMTSRIQTDDNEKEAKWADIDDDEDDWAPETIEWNDGTKITLTHTEGSAPGSQETSTLANSSSDQKRQPSPANNMPPAREAPKLLLSKPSSSLGSNTTILKVGASAEKQQSKQGGDLSKNTNDKPTLTSKGASAVRSPWAPLPPVEKASPLAPNPPAQNQVPRFNHVEPSRLDAGPAPPTKEIAADDFNRSWRDRQPTAPRELYNSQSGRYEPVSDNRHGHLRNDRSGKNDGHFRPASLLQRSMHEQSGPAEPSPAFQTHRSPTEGSQWGRRRASSNVSGGSGGFARRMSLTRPELPFKGGPPSTGTLERSASPNTRQMQNGPVAPSLGSPSQQSHRSLDHGPPNFNQTSPSSQTNVPSQGAADGQTSQPPVMVEDPVAMQQRIMREKREMARQRRLEQEAKEEAAKQERIRIKLQSIGVPANELPGAKDSTPSSNSESKKPTGPPSTSTTVISSPPKPPVPELTGEPKQYGMMKVHHPESVKKLVASSEKPPEKPQQTGNQAQNHQASPHKQAMSDASPTVNGSKPAQEGQTKTSQPIYGPQPEERPSNWKYSVPATSTYSWPSSKGHTAGLGALWGPPTNDKALGNGTFDRNLASFPSDLSSLGLTEQQHLYPQQAQEGAEIPEGISRPLPPPSKAGPDNAKPLSPLSSSDHMRPDRMGENPKPIAPPGPIAPPSYNQGQRWQQDRLPHRNQETAAWSNFHLVARKSELEENERFHQDLKALREEEAKTGIASSLQTTFNETWRQVEAGERPGNRNIIGVVSTTSDKEPQSSPFHQIDSVSGLPFGDKQKAVPPPSTRGSRFFPPASEPKRPNNQEVMPPRSQSPPPPEEVSSHPVFTGDSQRPLVHLPNPKPRVKLPPGSLSAPSPPPPPPAPATFAAMVASPPPARTPAQPIASTTSWQDRFNGLFGKKTSQPVQRKNSSLAVASATKEPLDVISSSSSAAVSFPQYDEKRKFIGEPGRATTKEVEDEEAIFEDREAGSLPVVKVPDMAPRAAWHPAPKQSRFRTKYQKPVLSQSIEPYIIGSIERDSNGEVSVIVRPPGKSLKMVPLPKRGGSSSGKLRSNPKNRSRNPRSREGSGSYQNSHTAKKPVSTTANTTPPASLSSSARQGSHRSHQSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHS6</accession>
    <name>D4DHS6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019244.1">
        <property type="nucleotide sequence ID" value="XM_003019198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHS6"/>
    <dbReference type="GeneID" id="9577484"/>
    <dbReference type="KEGG" id="tve:TRV_06733"/>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="421" mass="47039" checksum="AFD47A6F8E7E1D2E" modified="2010-05-18" version="1">MSEAARTMDGVFAVHKPADITSAQVLRDLQRQFNRSDFFKPWLAAERQRLQDEPSWKNRRRGKKSKWIDVKLGHGGTLDPIATGVLITAVGKGTKQLNNFLACTKTYEAVVLFGVATDSYDRVGKVVSRAPYEHVTREKVEEALKKFRGKIMQRPSIFSALKVNGKKLYEYAREGKEPPAEILERPVEVSNLEIVEWYDGGSHKYVWPTEEAEGPEKDIAKKMLAKGSTLETEPASNSTNDPVASETLDQKEGTSQKRKTPPPSDTADNEPKEDRKEGETSLAAKRQKLDTEGQGEQVTTIEEKKLPPTAPAEEEEPSPKPPAVKLTMTVSSGFYVRSLSHDLGLAVGSNAIMSELVRTRQGDFELSPDKTLEYSDMEAGESVWAPKLQRFLDEWKNKGSEQEEQPEDKSVATDEKQEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHY4</accession>
    <name>D4DHY4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019185.1">
        <property type="nucleotide sequence ID" value="XM_003019139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHY4"/>
    <dbReference type="GeneID" id="9577188"/>
    <dbReference type="KEGG" id="tve:TRV_06791"/>
    <dbReference type="HOGENOM" id="CLU_011171_2_0_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="2">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="533" mass="59567" checksum="5618BABE60960E11" modified="2010-05-18" version="1">MRVLKSKEKDWVYAPSQKPSVPDAILQVIGSTVISSCISSNASYPIPGEKDSPDSMVENYDTPTIHMSIIVPNPEAECMARINHKGQFVIVDARPLLTCMGFGKEVFKLFKSYYKKAVNSNILEDPFMFLSLDCPPGIYDANIEPSKDDILFEDHQAVLQIIEGVFMDIYNLETSTIIPTPDTQQSYLSNQLTIDISSPASTKNRGRFRSNEKLTSTVNPWTLSLAAQRLRDPESQLLTPQREFQDPRNNIPPRSPNIRVKNSRISMRQATLSLHDNGRVSLFNTQSPQRTSNGSPRMVTPPRVPAPNIPRSIEASVQIAEGNSARGKEGMYVIRPTPQTPPPSRAFSAATHRQAPIAVTFSRSNDQIPPNPHSISGRLHCNHRSDHKISGYGEIRPYKLTVPSGSHLQTASTNLKSRFQPDLNQKRNHLTSYRKNNFSTEIILYQSQSTMECMYETTIPNGGETTQLADSIKRLVNTDQYVKSGSLMAAFSPADLTSSISYWTNKLHTLAKNPSFQRQLRQLSFLTPSNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI09</accession>
    <name>D4DI09_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019132.1">
        <property type="nucleotide sequence ID" value="XM_003019086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI09"/>
    <dbReference type="GeneID" id="9580090"/>
    <dbReference type="KEGG" id="tve:TRV_06816"/>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="21142" checksum="F16034BCB8522E9C" modified="2010-05-18" version="1">MYKAAHPDSKDTFSISWFPYYLNPHAPEIGVDKTEYLNARFGADRVAMMQARLAQVGQAEGINFKPGGRTGNTRESHRLIQLGKTKGEAVQTRVVEELFASYFENEGDITSRDTLIAAGVKAGLDESEVKAWLKSDQGGPEVDREVDEAKRAYISGVPNFTIQGKYQIGGAEDPTVFLETFEKVRAEEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI11</accession>
    <name>D4DI11_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019134.1">
        <property type="nucleotide sequence ID" value="XM_003019088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI11"/>
    <dbReference type="GeneID" id="9580080"/>
    <dbReference type="KEGG" id="tve:TRV_06818"/>
    <dbReference type="HOGENOM" id="CLU_994635_0_0_1"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="280" mass="32599" checksum="04E6BA06E8AA1D44" modified="2010-05-18" version="1">MATDSSILDESQDTLGFKSPQLPQTQSVLFTRLPAELRERVYFFVFGGFPRIKPDEKPLYWISGGAPRRLKNHAVDKSMTLLQACQRMYFEAFDFFYQNITFKVFTPLTGVTLLPTAAHNSIRTLWVDIRLNSELGCDCCDEKVEGYFNEATWSKTVKVLNERLPGLRHLHISIIRRKESRSGDYFRPLLEEKVYPTLMGMKKLHCFQVVVNFENVVPANAPFEMVTSDYSAAYEIQSEREWLSDKTEEEESTDNVEEEYVTQYKRERNDSVDGWKIVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI43</accession>
    <name>D4DI43_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C3HC4 finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000394">
        <property type="protein sequence ID" value="EFE38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019127.1">
        <property type="nucleotide sequence ID" value="XM_003019081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI43"/>
    <dbReference type="GeneID" id="9582612"/>
    <dbReference type="KEGG" id="tve:TRV_06850"/>
    <dbReference type="HOGENOM" id="CLU_036494_0_0_1"/>
    <dbReference type="OrthoDB" id="4174185at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="467" mass="50146" checksum="8A433A2BC80BC1C3" modified="2010-05-18" version="1">MPPPPPPPPARLHPPLRRRSEEPMLNWPFPENAPVSPQALDQADRLQWLTSSNRGSAGYSDGSGMPPNYGQPGYGSGTTRSRHQSMEAYPGSFQHGLSSPQSRQRANPQVTTGYLVPYARRQNDGAGSNSSSANINANNTTANNTNAINKIHSGGFNYDSLARLQGSSPSDLTSLAEPVPGFYSSSVPDVNDTNQNFNHFMAGYQDAIASTQAGRSDYDPDILLGQQLSQRQASQEPGSSPAFSAASPTTPQQAHQDTRPVLPLGSAGPRLSASDIREIMGSAMDFGSSPDQPQESEMQDQDQDEDQDQDQDQDQDQNQGHSQGQNQNQSQDSETFGYSINPSSSGMPTTPAQRRRSAQDMASSEHESARHQGQVGSDGLTQRRVRMRTLRVSPASSTQQPSTASGSQPQLNPAASSAAANTATSSLQQSRSLFFPATDLVTPATTSSTRSIFPTTWPLWTEGSREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIB4</accession>
    <name>D4DIB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
            <ecNumber evidence="8">2.3.1.38</ecNumber>
            <ecNumber evidence="9">2.3.1.39</ecNumber>
            <ecNumber evidence="5">2.3.1.86</ecNumber>
            <ecNumber evidence="4">3.1.2.14</ecNumber>
            <ecNumber evidence="7">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">TRV_06922</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 29">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EC" id="2.3.1.38" evidence="8"/>
    <dbReference type="EC" id="2.3.1.39" evidence="9"/>
    <dbReference type="EC" id="2.3.1.86" evidence="5"/>
    <dbReference type="EC" id="3.1.2.14" evidence="4"/>
    <dbReference type="EC" id="4.2.1.59" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000402">
        <property type="protein sequence ID" value="EFE38406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019051.1">
        <property type="nucleotide sequence ID" value="XM_003019005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582540"/>
    <dbReference type="KEGG" id="tve:TRV_06922"/>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 29" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16 29" id="KW-0520">NAD</keyword>
    <keyword evidence="14 29" id="KW-0521">NADP</keyword>
    <keyword evidence="15 29" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="32">
        <location>
            <begin position="1693"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="30">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="30">
        <location>
            <position position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="EFE38406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2111" mass="234518" checksum="84CC8DAF2DB773F3" modified="2010-05-18" version="1">MFGPSTGPQTGINTPRSSQSLRPLNLSHGSLEFSFLVATSLHFHASQLKDSFAASLPEPTDELAQDDEPSSVPDLVARYLGFIAHEVEEGEDDSLGSYIEVLKLVLNEFERAFMRGNDVHAVAGSIPGIPAKKLLMVENYYAARAAVNRPTKPHDSALLRAAMEGNAKLYSIYGGQGNIEEYFDELREIYNTYPSFVEDLISSSAELLQSLARDLDAIKLYSKGMDILRWLHDRDTQPDTDYLVSAPVSLPLIGLVQLAHFMATCKAMGKEPGDVLDTFSGTTGHSQGIITAAAIATVTTWESFAKAARAALTMLFWIGLRSQQAYPRTSLAPSLLQDSIENGEGIPTPMLSIRDLHRSAVQEHIDATNQHLPEDRHIAISLVNSPRNFVVTGPPISLYGLNLRLRKVKAATGLDQNRVPFTQRKIRFVNRFLPITAPFHSQYLASAFEAIAEDVEDIKIPARSLRIPVYDTNTGKDISKLGDEDIVPALIRMITSDPVDWEKATVFSKATHIVDFGPGGISGLGVLTNRNKDGTGVRVILGGLIDGTNAEVGYKPELFDRDEDHAVKYAVDWVEVYGPRLVKTSVGQTFVDTKMSRLLGVPPIMVAGMTPTTVPWDFVAATMNAGYQIELGGGGYYNAKSMAAALTKIEKAIPPGRGITVNLIYVNPRAMAWQIPLLAKLRADGVPIEGLVIGAGVPSIEVANEYIETLGIKHIGFKPGSLDAIQQVINIAKANPSFPVILQWTGGRGGGHHSFEDFHQPVLQMYSRIRKCDNIVLVAGSGFGGSTDTYPYLTGTWSRQFGYPPMPFDGCLFGSRMMVAKEAHTSKAAKEAIVAAPGVDDAKWEDTYKGAAGGVITVRSEMGEPIHKLATRGVLFWAEMDQKIFSLDKAKRLPALKKHREYIIKKLNDDFQKVWFGRNSKGVTVDLEDMTYAEVVHRMVELMYVKHEARWIDDSLKRFTGDFLRRVEERFATEKNRESRLQSYSQLDTPYPTVQEILDAYPASADQLINAQDVQHFLQLCQRRGQKPVPFVPSLDENFEFWFKKDSLWQSEDIEAVVGQDVGRVCILQGPMAAKYSTVIDEPIKSILDGIHQDHIKGLIQDVYNGDESKVPTVEYFGGRLALVDDEDRDIDGLTISEDATRVSYRLSSSPSANLPELDRWLHLLAGNIYSWRYALFTTEVFIQGQRFQTNPIKRILAPTRGMFVEITNPNDSLKTVISMREPCQSGKLVKTVEIRLVEKNRIALTLFEGRTAESGVVPLPFYFTYHPETGYAPIREVMEGRNDRIKEFYYRVWFGERTVPFDTPAAAIFDGGRTTVTAQAIADFVHAVGNTGEAFVERQGKETFAPMDFAIVAGWKAITKPIFPRTIDGDLLKLVHLSNGFRMVPGAEPLKVGDILDTTAQINAIVNQDSGKMVEVCGTIKRDGEPIMHVTSQFLYRGNYTDYETTFLRKDEVPMQVHLATSKDVAVLQSKEWFRLDEGNVELLGQTLTFRLQSLVRYKDKTVFQNMQTTGQVLVELPTKEIIQVGSVDYDAGVSHGNPVIDYLQRHGSAIEQPVNFENPIPLSKSPLVLKAPASNETYARVSGDYNPIHVSRVFSSYANLPGTITHGMYTSAAVRSLVETWAAENNIGRVRSFHASLVGMVLPNDDLVVKLQHVGMIAGRKIIQVEASNQNTEEKVLIGEAEVEQPVSSYVFTGQGSQEQGMGMDLYATSPVAKEVWDRADRHFMENYGFSIIDIVKNNPQELTVHFGGPRGKNIRQNYMSMTFETVNADGSIKSEKIFKEVDEKTSSYTYKSPTGLLSATQFTQPALTLMEKASFEDMRSKGLVQRDSSFAGHSLGEYSALAALAEVMPIESLVSVVFYRGLTMQVAVERDEQGRSNYSMCAVNPSRISQTFNEQALQYVVENVSETTGWLLEIVNYNVANMQYVCAGDVSLPKKGYNHFKTDILISLQLRALDSLTNVLNVLKAQKIDIPALMQTMSLEDVKSHLVQIIDECVKQTNAKPQPIVLERGFATIPLKGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPSKLIGKYIPNVTARPFELTREYFEDVYRLTNSPRIGNILANWDKYEEPQDTPAESTDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIR2</accession>
    <name>D4DIR2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000410">
        <property type="protein sequence ID" value="EFE38259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018904.1">
        <property type="nucleotide sequence ID" value="XM_003018858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIR2"/>
    <dbReference type="GeneID" id="9580074"/>
    <dbReference type="KEGG" id="tve:TRV_07072"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="98251" checksum="63BDC0A77439532C" modified="2010-05-18" version="1">MTDEGGSAGGGDGDNPGSRTVPVTSPPSPTVSRHDSTPRLPEIRFSIQRRPTAIAAAGGDMDERTSLLDAGSQYQRSYSTNPASPRPDAFFRHNSTAGSLRMSKSHSRANSQVVRFTPSNRAAEFEPAEADDEPTKPLNAAPYSDDRVWYDQFTSTDWVHDTIADGIRLRELRSRRDIRGKLLAWVDGAQGWVLVAIIGLLTACVAYFVDVTEIVIYDLKEGFCSNNWFMSKKHCCSSDEEICLAWRSWSEILESSTIDRKWIDFGAFVFWAVLLAAASCTLTLLTKTVVPSSISLTTLDEDFGAVGSASPDETSRPTKTNLDVRSVQDVVPPPMVYYSAAGSGVAEVKVILSGFILHGYLGVQTLVVKTLALVLSVASGLSVGKEGPYVHIATCIGNICCRLFAKYHYNDGKRREVLSASAASGVAVAFGAPIGGVLFSLEEVRTFFCCIAAALSLKFLNPYQTGKIVLFQVRYVSDWEIFELAIFMLLGVLGGAFGALFIKASKLWAQTFRRIPVIKKWPMLEVVLVALITGLMSFWNRYTKLAVSELLFELASPCDYEGQTETGTGLCPKREDIPDVIKYLLVAFIIKSFLTTITFGIKVPAGIYVPSMVVGGLMGRIVGHVAQYFVVHYPNFFLFGQCPSTKLAESCVNPGVYALIAAGSTMCGVTRLSLTLVVILFELTGSLDHVLPFSLAILCAKWVSNAVEPLSIYDLLTDMNSYPFLDNKLHPIANIELGDIVPRVRKNRVIDISSSPLVSATELREKLDKLLMAGELDGGLPILNKNILVGLIPAPELEYALDKLPSEEQDTMCLMSMQSSYLGEGENDTNVADFTPFIDPSPVSLDIHSPINLVYQCFVKLGLRYMCVLRDGQYAGLVHKKSFVKFMKETEKASAAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ04</accession>
    <name>D4DJ04_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">TRV_07169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018809.1">
        <property type="nucleotide sequence ID" value="XM_003018763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ04"/>
    <dbReference type="GeneID" id="9581369"/>
    <dbReference type="KEGG" id="tve:TRV_07169"/>
    <dbReference type="HOGENOM" id="CLU_090154_1_0_1"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="19970" checksum="C5856767B7D7117A" modified="2010-05-18" version="1">MRAYWFDDAEGDQRAPHDSGRAVDTDYLARIGVLYKKCPSVDDVNALASERGYKNRDEITVSPEKMGAVYEEKVKSFFDEHLHEDEEIRYILDGEGYFDVRSRDDKWVRIKVEKEDLLILPAGIYHRFTTGESNYIKAMRLFQDEPKWTPLNREPALDNNSFRQSYVAAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF8</accession>
    <name>D4DJF8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018636.1">
        <property type="nucleotide sequence ID" value="XM_003018590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF8"/>
    <dbReference type="GeneID" id="9580787"/>
    <dbReference type="KEGG" id="tve:TRV_07324"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="733" mass="80488" checksum="4791778903B620AD" modified="2010-05-18" version="1">MKMPVSFKVKNRTVNFNYIPDLDLRRRRVFDELDATHFQSLVVFVAEIGFFTDGYDIFAVGMIIPMLAHVYWQGTMPIHIETGMRAATLLGTIIGQFVFGILADLYGRRKMYGFELLIVTLSTIGVTMAADGASGSMSIVAWLIAWRFIMGIGIGGDYPLSAVITSEFAPTRSRGRMISTVFYMQPCGYLAATLVALIAIVAHRGSIPQNIPTRVEDIVSCMDNPECRRAMDSVWRWVIGIGAVPSAIAIFFRFSIPESPRYTMEVLNRPDEALEDVNEMGWQRVPQKTITPGDVEMQLPPPEQQSQSQRPPMAEGNNLQAEKPPTFSHRPASAISNPSNQPVSNDWSHFDPRQHQRSTSRATDGASQRSPRRVSRTHTVSSAHSGAGSSLSFSTSNDDEPADSTLVEDDFSPPTKEASQWARFRTGFYNHFITNGHWPTLLGTSLAWACFDFAFYALGPNSYKVVGKIFNESVLCFPGVIKHGGQMPTPCLPPNRSLYEDVLQNAWHSLIIVSAGSITGGLGMIKLIKRNSPRTIQLYGFIVLAVIFVIIGVCFQVVNRSTSVPLIAFLYVLSQIFFEIGPNVTTFMIPAELFPTRFRCTAHGISAMTGKIASVLVQVFVAYAPIGPYKPSDNNPSDPNSTDTKAQWLGYVVIIFAAFMVLGAAVTKWLIPETRQVDGLARPLEELQYLAKIRRPAKKKAAAPEPANAQGASAAANGPNGVLTGEGNANMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJG1</accession>
    <name>D4DJG1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018639.1">
        <property type="nucleotide sequence ID" value="XM_003018593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJG1"/>
    <dbReference type="GeneID" id="9580790"/>
    <dbReference type="KEGG" id="tve:TRV_07327"/>
    <dbReference type="HOGENOM" id="CLU_016546_1_0_1"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="544" mass="60015" checksum="D41D7DD29005FE49" modified="2010-05-18" version="1">MAESPFPLRRSSTIPRTRAVSTGRYSLGAHELSTSGPSPADEILYSSPSAKIFKFELPNSSSSSPILPDLDYPVDAIETLPWELPTERLASIGPLKIETVAGSATFLKSGSVVYPLLKNSQCWCVDQVSRFVFRIRKLTYYRVELPGETEEDKSRVESFKEVLSGIIRYEITPCPFKRGFSVVLPEEAKTPKKKKAWQPKLQPMPPFPPLNLPTDVPLAASHDLESNGGPVLDVRKATSREQDQDQDTGNDPSVATDGEDFLFVPDNMQSDGSTVTPPPQAFQSLVAKFQQLQDASPAEEKEHQEYMDDSERMSSLGSFHTCEMDDSISPSDTHYSDPPSPWNEGTTAAPSLAHGEDTSDQSPSIPESDPFIDSDDNNMSQIPREFLSTDLHSTPTQPSFDRHGSIYLSSEEGVDVNEPSSDLRQRLRSNRKRDLSPLPPPSTLYYPSARSPANHLTHTIMKKTCTYVLGPPVQFLMLLLRLAAKVAATRPSPTSPDLPDPYSDQDDIGDLSEDDFGIPIPYTSSLKQVNSNSLSVYDSLDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJV1</accession>
    <name>D4DJV1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018523.1">
        <property type="nucleotide sequence ID" value="XM_003018477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJV1"/>
    <dbReference type="GeneID" id="9584452"/>
    <dbReference type="KEGG" id="tve:TRV_07469"/>
    <dbReference type="HOGENOM" id="CLU_2335162_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="98" mass="10063" checksum="345841537301E1A1" modified="2010-05-18" version="1">MYPEAEEVSQELGSGAGHESAPQPRCRAHPAAGESGEEPADEGEPPDEADGGGGEAVGAQQIRDQGPKAAVIDAGDEEAKGRGRDPGGLFLFHYSFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF3</accession>
    <name>D4DKF3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018330.1">
        <property type="nucleotide sequence ID" value="XM_003018284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF3"/>
    <dbReference type="GeneID" id="9580014"/>
    <dbReference type="KEGG" id="tve:TRV_07675"/>
    <dbReference type="HOGENOM" id="CLU_2529103_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="84" mass="9840" checksum="5636700AEB5CAFE3" modified="2010-05-18" version="1">MVSQRLARHSCISLFFFSSTISTSSTIFYYLHHLHHLSIFFSSRFLLRLCFGDPCLSQQARPSPKNKTTKKKVLRDKKTSWKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH1</accession>
    <name>D4DKH1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018289.1">
        <property type="nucleotide sequence ID" value="XM_003018243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH1"/>
    <dbReference type="GeneID" id="9579985"/>
    <dbReference type="KEGG" id="tve:TRV_07693"/>
    <dbReference type="HOGENOM" id="CLU_1234727_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="224" mass="24429" checksum="D0E9F3928D380561" modified="2010-05-18" version="1">MFKYAGKKVIAKRAAEDDGAAEDEARRPLASPFSTPKQEALASSSSSNPAYVNQQMPPTVQQHLSQLSAAFHQPSPHTSPMVRLQPPVTQQFSSGTQPAYHTYPVGNFEARSSVSFRQDQMCTPESGVAGNIPPANMNTMASPIYSNILSPPRSPWDQTYPNVNQASPYPPRTPSMPSAVLQFPSPSVSGEVTHACQPKSRKPSRKRSADTSDRPESPLKKMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKS8</accession>
    <name>D4DKS8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial export translocase Oxa2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000482">
        <property type="protein sequence ID" value="EFE37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018183.1">
        <property type="nucleotide sequence ID" value="XM_003018137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKS8"/>
    <dbReference type="GeneID" id="9579554"/>
    <dbReference type="KEGG" id="tve:TRV_07802"/>
    <dbReference type="HOGENOM" id="CLU_029282_1_2_1"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="336" mass="37696" checksum="9728EB96A28AE2DD" modified="2010-05-18" version="1">MSLMRPRLGFSVLSSLGCGRVLIAAPSRRNFHASNPNQIIDTSVLVAHDVIQGFHSISGLPWVLSIPITAITVRCCVALPLQVWSILKARQLQKLNPLLLTWSRVCQKKAMDEAIMEGRHLFPKAIEVSWQQDFKLKRKELYKRWKIRPWAGYASILQLPVWLAMMECLRRMVGMSGGLLSIIQSWIESKVDGAPIIEVEPSMAMEGALWFPDLLVADPIHVLPVVLAASMFTNVTWGWKVKSAAEISKLPRSEAIRERAFKILKRFLQGLSIWLAPVMIYSQAPAGLLIYWISSSTFATAQTQIVRRVMRTKAPPAPCREKSVGSIHDKTSTAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKV2</accession>
    <name>D4DKV2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018130.1">
        <property type="nucleotide sequence ID" value="XM_003018084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKV2"/>
    <dbReference type="GeneID" id="9579339"/>
    <dbReference type="KEGG" id="tve:TRV_07826"/>
    <dbReference type="HOGENOM" id="CLU_3034074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="55" mass="6275" checksum="14FD3A2F23D4DB59" modified="2010-05-18" version="1">MEMEKTRGEGKEKAEMKKKRKDGSERRRVSSPPGPEQRSTGFVGIEHYVSLRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKV9</accession>
    <name>D4DKV9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018137.1">
        <property type="nucleotide sequence ID" value="XM_003018091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKV9"/>
    <dbReference type="GeneID" id="9579346"/>
    <dbReference type="KEGG" id="tve:TRV_07833"/>
    <dbReference type="HOGENOM" id="CLU_020375_0_0_1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="464"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="552" mass="61468" checksum="7AA89D34E1906760" modified="2010-05-18" version="1">MSLKQQEIETWVQALAHYDNNEFEDAIAVFGGIADTSKILFNCGVIYATLGEHAKAVDCYQRAIALDKYLAIAYFQQGVSNFLIGDFEEALANFNDTLLYLRGNTTIDYEQLGLKYKLYSCEVLFNRGLCYIYLQEIESGMNDLTYAAKEKAKPDHDVIDEAIAETAEGYTVFSIPVGVIYRPSEAKVKNLKTKEYLGKARLVAASDRANTFTGFQGHETKIPVFESSRDDRPPENISYGATNLVQKNLAARSRQQSEPPISRNAFPPTPPPDEKASSLAPSNGSSGSLTRKQSLTRATRPPVLELGRASSEQTQSIGGSTAVDSQQPKLQQEKPRVGTVRTASEPRGPASRLSAIRYGPPPNGKLLFRETTGQHRRPMSNISPLSEEPQAYYTMYAPGLGPGYAAENGHTRLPEYINEEGYESEPLDDDAAECIQFEMVGSRPPQHQLSNRHRHSSRRPEIKKIRVKVHADSDTRFIMITPTTEYAEFENKIREKFGFKGNLKIKMQDDGDMVTLADQDDLDMLVAAAKQVARKENNDMGKTEIWVAEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ9</accession>
    <name>D4DLJ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017907.1">
        <property type="nucleotide sequence ID" value="XM_003017861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLJ9"/>
    <dbReference type="GeneID" id="9579785"/>
    <dbReference type="KEGG" id="tve:TRV_08073"/>
    <dbReference type="HOGENOM" id="CLU_110312_0_0_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23713" checksum="5BEA7D5250D508F1" modified="2010-05-18" version="1">MENDTVDLTGPSPVTTSHSSRGPVPQTLQPSRSRRSASPDFNDNRGKVKRRRLSNRNNRSSTPTAGPSSQSHQAAETMIPGEIEAVDLTSVDDSSSLAQVLAKQREDAIIAQKNATNDKEAKSILIAYKCPVCMDVPENATSTICGMYCALIPHNDTLLNIFLSPLKYNETRRTLEGAGKGARGNCPVCRKSITVVDNPGPRRNLVPLQFKLITRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ00</accession>
    <name>D4CZ00_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025775.1">
        <property type="nucleotide sequence ID" value="XM_003025729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ00"/>
    <dbReference type="GeneID" id="9582018"/>
    <dbReference type="KEGG" id="tve:TRV_00037"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61226" checksum="3516DAF5CD67AF0D" modified="2010-05-18" version="1">MRLEHDGGSLAGDSDREELNRLGKKQVLRAFLINNQRGFRFLSILGFSCAVLITWEASLVLFLTGLRNGGHAGIIYGYIVIWVGNLAVFTTLSELVSMAPTSGGQYHWVAMLAPKSMAKFLSYITGWLTVAGWQAGFASACFLTGSMIQGLIIFTNPSYSPSSWHTTLLLCAVALYCVFVNVVTSRLLPAFEKIALALHVLGFLAVLIPLVTFGEKNDANLVFKNFINEGNWSSQGVSFLVGLIGNAFAFLGQFTVLGLFLMYPIFFWLTILIGLDGAYHMSEEIQNPSITVPRSIILTLVINGSLGLSMLIATLFSIVDLSASIESPTGLPFIEIFRQSTGSIAGSATMASVIVTLALFANCNYLASTSRMTWSFARDRGLPGWKSLTKVEKRTEVPLMSILVTATITILLSLIVIGSTTAFNIIVSLTVACLYLSYLLATSMLLYHRCVGNVSYPSSNTGMGQTLANTTGARLIWGPWHLRGAMGIATNIFGVIYLTVILIFSFFPADASPTAEGMNYSVAIWSFVIVFSIVYYLAYARRVYDGPVVEIDTTPSIEPALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ47</accession>
    <name>D4CZ47_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025757.1">
        <property type="nucleotide sequence ID" value="XM_003025711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ47"/>
    <dbReference type="GeneID" id="9581988"/>
    <dbReference type="KEGG" id="tve:TRV_00084"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_0_1"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="207"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="416"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="684" mass="74147" checksum="088995C9A19C974E" modified="2010-05-18" version="1">MPPPAQSSWQRPAAGQPRPPADPLAYASSPSPSPPPPFAFLSSSLWLVCLEFIFINTQKYKYLIERKKNRQATLCLSNHVLFPFLLPSKRSLTATTEQPQQVAVLCELAIYIKSTHAHLTTATALLDAAVFLSSYSVPPGSSLTSSPSPSTLSRPPPHPLLRNRPSLLAAQIQAERHVLGLKPALPRLKHILLRQWPNKKDGGVVGQAGWTSSVINLVNTIVGAGALAMPHAISRMGMFLGVTVVLWAGLTSAFGLYLQTRCARYLERGTSSFFALSQITYPNAAVIFDAAIAIKCFGVGVSYLIIIGDLMPGVIEGFVGGTSGVDFLYDRHFWVTAFIIVALISIGYLVILVVAHFIKGDTMADRGPIHFIEWQGLISALSVFPVIVFAYTCHQNVRGKKKPGSAVQILILMLVFFMQMFSILNEIANDSHYRTTSVIVTSIGSAAATYVLVGVTGYLSFGDTIGGNIVGMYAPSLTSTIARAAIVILVIFSYPLQIHPCRASLDAVLKWRPNSNKSPANTHSPNRNPLIPRTSPPSEGMSDMRFAIITTVIIVLSYIVAMTVSSLEAVLAYVGATGSTSISFILPGLFYYKISSPESAAHQRLMKEDDELEAEEHSNEIDPSADASQGLLGQSYARFMSRSTSQWRRGLLRKLSLGLVVYGVVVMVVCLVTNTFFLASDIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ68</accession>
    <name>D4CZ68_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC a-pheromone efflux pump AtrD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025691.1">
        <property type="nucleotide sequence ID" value="XM_003025645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581939"/>
    <dbReference type="KEGG" id="tve:TRV_00105"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003218">
        <property type="entry name" value="ABC a-pheromone efflux pump AtrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="43"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="373"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="766"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1319" mass="145498" checksum="5623DD2B602AD701" modified="2010-05-18" version="1">MPQTSRPGEQPPAVSGPVEEQRLRAGWTSLFRFTSKRHIAPLALALAFSIARGLAVPLLAWILGKLFNVFSSFGSHSISAGQLLSTTSLECTYILALGSGVWFLDWAYFSLWVIFGELQAKNARRWAFEELLHKEMRWFDGVTDGLPAILPRIQAYIRDLQLATSQPLGATLYNLTAAIAALVLALYMSWSLTLVCLASVPLCAIIIAFFSSKVQPKIEGQQVALTKASKIATTAISSVDVVKHFNSQDTEAEKYKTAIGIAAHWYYKEALYSASQIGLISFLTFGMFVQGFWYGSYLVAKGSLNAGQVLTTFWACLQATQSIEEIIPRLIILEKGRTASAAIKHIFNDTCHTCTLRELGGSTLSPVFCEGDIRFSEVTFAYPSQPGRRVLDNCSFFFPAGDTTFVVGKSGSGKSTIGNLLMRFYAPTFGEIHIDDRLIQTLDISWIRNNITLVQQESILFNETILKNITFGSRNTEETTAQDIYAATKLAGLQDTILSFPLGLDTVVGLGGRSLSGGQRQRMALARARLRDTPILILDESTSALDYSSRISLMNAIRAWRQGKTTIIITHDLSQIRPQDFVYVIDKGKIAHQGYRHILEKKAAGVFDLNNLATLPTDTTPTTSNWSVKSPGPMSDNRRRSSFSSIERSMTERRSLTTPISPFFHNSFSLERTFSEAEQSSQSRRSSMVERLIDHTSPRFRKSPLDALDDKRVEKDLEQPQPATRDNQTPSPLKPNNEPLQKSYSMSQILLTVIPSLSPSNRMSLLFGFVAAFFYAAATPCFSYVFSQLLTTFFVVENRSRLAMQWALTVLGVAVVNGIASFFMHYLLERCGQAWVDQFRYKAIRRILQQCKSWFERDENSLSNLTHCLDRNPEEMRNLIGRFACFMFVAVVMTLIGFIWGVAVCWKLALVGAATAPPLYGLTRLYEKISGFWENKSNEASEIMAGVFTETFLDIRTVRSLTLESYFHTKHNKSNGKALTVGIKRGCYSGLLFGFSECSILFVYALIFYYGAILVSSSQYSAKDVLMVFSMLLFSMANVRGVLSLVNMPEDQSHEGQGNLRIHDLTPLNFKDVDFSYPNRPGKKVLNNFNLKIPKGSCTAIVGPSGSGKSTIASLLLALYPSPPSAGNIGTITLGGVNIRNIHVPTLRSLISVVPQDPTLFPASIKENIVYGLPENSSLNTSTNIQAAATAAGIHDFISSLPSGYDTLVGDGGVGVSGGQAQRIVIARALVRRPQLLILDEATSSLDVESATVIKQTVTRLMASGRSLTVIIITHAKDMMELADNVVVVDGGVVVEEGSFPDLSSRSGGRLRRLLRMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZA6</accession>
    <name>D4CZA6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000007">
        <property type="protein sequence ID" value="EFE45071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025682.1">
        <property type="nucleotide sequence ID" value="XM_003025636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZA6"/>
    <dbReference type="GeneID" id="9581921"/>
    <dbReference type="KEGG" id="tve:TRV_00147"/>
    <dbReference type="HOGENOM" id="CLU_041557_0_0_1"/>
    <dbReference type="OrthoDB" id="4173234at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40701" checksum="86149BB899E4E26E" modified="2010-05-18" version="1">MDILADESGAFEDLHLSGSQFKLDMMPPLISSAKQPYEDANIMLNNGQGFPMENIPNGRHTPFLDRQNPQIAQEFTLADENTADCVRKLTDLGLAQYNQLRQLKRMRSCTNRDKQGLLTLLHNYPIQEIMETARQLTELVDQFIQVPVIGGDLFSSSPDSAGEPVPDLRSPFFGDPLEITDFSDLLSQPFIDVSATPTSTGSNSSNSQLSSSISAGSGIQMDTSTTLHTISCYLRLARLFVLFFTDLHDFLLFPNLADPMLDDKSRLFPGLKLGSFQPYVGMELEISIVVQVSEHILNRLCNSLGLPQGQDTGQSRLRSEMITPAMLQAVQVQERLDAQDEKGDTFTQLPLVINSVKKMIKVRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZC8</accession>
    <name>D4CZC8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025647.1">
        <property type="nucleotide sequence ID" value="XM_003025601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZC8"/>
    <dbReference type="GeneID" id="9581886"/>
    <dbReference type="KEGG" id="tve:TRV_00170"/>
    <dbReference type="HOGENOM" id="CLU_036009_0_0_1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="506" mass="56707" checksum="A80F6A41D2381E74" modified="2010-05-18" version="1">MPLRSKRIRANIEWKEIYETDIHPRISEILTKYGLSFGVDTLDRVQPWDDSYEIKDVITITTHDASPRKDWQDAADTVLAMVKEKVPSHVSHPIQVEIINLDKMYQDVSSPLPNDRSIVGPLEQVKGRIVEEVQVSMQDAWLSIAFHLRHHRNSFDEPMKPTILVICRPHSVCDFAEAEDRLLDILNELDISVYLELLPGRTVLANPGPKPTPMYTHVEDLPEKPTNGSSIGVKGNETSAGTLGGWLILNLPKEQRQIKCALTCYHVIRGDDSSTTDHTDTHGVHWNDPRGQLTIQYPAAIDARAALDNLDKLCHNFPGDQRLEKQRNMVSDLLLGPGIGKVILASGSQVRNNHRVDWALIESPETFSKNKPPSIRQGNFMSPPAGHRYAPHPDTKIRQFDYVHEDDWVVKLGRSTLTSGIINGMKTVEWGPNFVTEEIQVMSHYADVAVDGDSGAFVVNEHGHLVGMLYAVTKESTSFNTAYITPFDAIQAHIKEVTNGGFLSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY0</accession>
    <name>D4CZY0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Terpene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025434.1">
        <property type="nucleotide sequence ID" value="XM_003025388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY0"/>
    <dbReference type="GeneID" id="9581690"/>
    <dbReference type="KEGG" id="tve:TRV_00374"/>
    <dbReference type="HOGENOM" id="CLU_005861_0_0_1"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017057">
        <property type="entry name" value="Ent-kaurene_synthase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036498">
        <property type="entry name" value="Ent-kaurene_synthase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="988" mass="110749" checksum="E3CC9CA9A5565190" modified="2010-05-18" version="1">MGVQHAELAGVADLGTNARLLIKRSFKDHDPRYGNGSMSCTTYDTAWVSLVTKTVGEQKHWLFPECFRSLLRTQSDDGGWRRETTSQVDCIVNTAAALLSLKRHAVEPLQLREEIHPDDLERRIDRAAILLRSQLEEWRVSETMHVGFEIIVPKLLTLLEEADAKFSFCFEGRDELVKINAAKLARFKPEALYGTVKMTPLHSLEAFVGEIDFDRVAHHKVVGSMMGSPSSTAAYLMNSTNWDDEAESYLRHVIHSAAGKGSGAVPSAFPSTYFEYTWILSTLLEAGFSASDLRCPELEQIYEILTRAFSNGDGTIGYGSYQQPALHLSTGINYISPDFQSDMDDTARGMIALNLLGGAVRPEPMIKAFEAATHFRTYQCERNPSFSANCNALLTILHQPDISLYTPQILKVVNFLCDSWWNTDGAIADKWSLSPLYPSVLLVKSLVRLLALAEQGDSSPEQLLRRDLASRAAITLFQACLRAMLSQHEDGSWNGSTEQTAYGVLILTEARTLCFLDDIRDSLDSAIGRGVSFLQANRGSQVGNFIWIEKVTYASPMLAEAYELAAIKAATSLSSSTSSVGGSLWYISTENTTKLIELFQQTPLFTSLPEWQIRASMTEARLFQPLLQARRLEVFPRKDMEKDKYFEIIPFTWTACNNRNRAFASTSFLYDMMIISFLNYQADEFLEAVAGPHYTGRTPELRRVIDTLFAGKSSNSELSRGVKRPYPEEDEEHSNGNNGKPQNNREVVVPLTKFTTFVLNHPSVKSASAWDRNGLRRRLKEFLLAHVTQIEDNARFQLEHPSSGGAYSTATDSFSHWVRTTSAEHTSCPYSFQFVSCLLGASLGQGKDCFGTAEEKYMAASVCKHLSTMCRMYNDYGSVARDKAEGNVNSVNFPELQMLAGSTGPATMEEKKKALFRLAEYERSCLDDAFKRLQEEGQRATSHMARKLHERKMEVWRMFCDVTDLYGQIYVVRDIASRMKVPAVNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D036</accession>
    <name>D4D036_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025369.1">
        <property type="nucleotide sequence ID" value="XM_003025323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D036"/>
    <dbReference type="GeneID" id="9581604"/>
    <dbReference type="KEGG" id="tve:TRV_00430"/>
    <dbReference type="HOGENOM" id="CLU_082161_0_0_1"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26493" checksum="B7DA5CA5F0893669" modified="2010-05-18" version="1">MSPTASIAGSHAPSAASDRDESTYLARSRMIHWARIALTSLSLVLAAAAVGSEGHALNYYKGTVKYSKFWLSLWPKELDLGPSTATIVCGTILLVFNLAYTVVAVMPSTDGRQPRSRVLLLNAFITIIAFSGFVASVAAVATSVIAYNPHYTDGGAQLGQTLNSWTCTWSFGEGVDSDGATISPVVNFGRLCRETRASLAILCVLIAVQFLSCLSAGCGWWLEVEMNKKRRFAASAESQVEKHHEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D076</accession>
    <name>D4D076_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025409.1">
        <property type="nucleotide sequence ID" value="XM_003025363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D076"/>
    <dbReference type="GeneID" id="9581645"/>
    <dbReference type="KEGG" id="tve:TRV_00470"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056059" evidence="1">
        <location>
            <begin position="22"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="154"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="349"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="698" mass="77542" checksum="6B95736D7D76959B" modified="2010-05-18" version="1">MVRFHKAVVGLLLSSSGLVTAATEPCAQVAEEQRKQKAGNPNATNFTVSAELAHACLTSVPFKSNDSLQLIDGLKYFWDWQTTKDFLKNPPQGYAVPGTDLEGGIAKIRQKAASNGYKNEFEFQFELDALVRTVHDGHFNLAMDLITTFAFTRSDIGSLVSLSDDGKNLPKIYSLNDLQGRSMNASALKTIDGQDATEWMKKFSFSGFFQDPDALYNGMLFNLPLTRVSGTGGFFTSRGLYTGTKMSVTFENGTTKEFGHTATSTADFSGVKDGNTFYEKFCSGKQQATAASLTDYEHTAFRDHRFLTANPISYPPFPLAQRTVPPVTPLRESMDGAAAGYFLEGKDSKVAVLNLRSFVGASENNDPLWDFSYTVTKFLEDCRKAGKEKLIVDVSGNRGGTIFLGYDTFKQLKTQLLPTGRIETPFNLRAIEQFDIIGTKVNYLLKHPRDPKAPAAEEMRDDIFDTNSYVDPNGRKYRSWDSYFGPETVEAGNFSRLAIWDFHNIPMSLKAGGLVVSGYGNRSHVAPQAFRKENIVLVTDGICASTCAIFSDLMNRNGIKSIAVGGQPRTGRMQAVGGVKGTQVLTFRELWSIAELVIKKYSTPREQRELEKTQLGQMYNKGKYVLSRLLNNGAGGRVNYRNAVFTDDRKRVPRQFVYEPAHCRMFLTKDALLDVKRWWGAVANSWWGDKGRCIEGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0H8</accession>
    <name>D4D0H8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025257.1">
        <property type="nucleotide sequence ID" value="XM_003025211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0H8"/>
    <dbReference type="GeneID" id="9580750"/>
    <dbReference type="KEGG" id="tve:TRV_00573"/>
    <dbReference type="HOGENOM" id="CLU_021768_8_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="36333" checksum="58E042EDF49A13F5" modified="2010-05-18" version="1">MTSLWMPRILRPDYTWPRPVLLRISEITPPVPRISGRIVRRLWGILHKGLYIFSEWYCYWFDVPFDGNIAQLPFGLLLKWTDRTSLEEAVAMQMVAAAGIPTPKILCYGEHPNDPYNRHISILMTRLPGITLENSRDPLDIETSGPWLEELKTCVSAMRQWSPPEKLFTGSVIGTAVHSQRVPNHIMGPFTTQNGLYDHLFSTASSHGFTSTEKFEEALTEARKIYERPHRVVFTHGDFKAHNILVDDDGHLSGFLDWESAGWYPEYWEFTTAMRFGRNTWWYQVASWMGGDQYSQELSSDVALNLLTVDSYIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0N2</accession>
    <name>D4D0N2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000037">
        <property type="protein sequence ID" value="EFE44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025200.1">
        <property type="nucleotide sequence ID" value="XM_003025154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0N2"/>
    <dbReference type="GeneID" id="9580693"/>
    <dbReference type="KEGG" id="tve:TRV_00627"/>
    <dbReference type="HOGENOM" id="CLU_122926_0_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="20212" checksum="6416697073BB184D" modified="2010-05-18" version="1">MLLEIEHSLESWDHTSLVTAVQNEESMQQDRDRMHCSEAWRNGLLLYTYRVFRWELGSSVPLPILYRARAITDHVFACRDKSMVSRQALLPLFFAGCELRDQSSRSKIVEFCCIWDRRTRYHMFSNTIPLLEEVWAEQAAKGFENVWWGQIVDKQHSSQDDHPLQMRLCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R1</accession>
    <name>D4D0R1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA excision repair protein (Rad26L)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025174.1">
        <property type="nucleotide sequence ID" value="XM_003025128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R1"/>
    <dbReference type="GeneID" id="9580667"/>
    <dbReference type="KEGG" id="tve:TRV_00656"/>
    <dbReference type="HOGENOM" id="CLU_000315_4_0_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18005">
        <property type="entry name" value="DEXHc_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058052">
        <property type="entry name" value="DEXHc_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="240"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="611"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116469" checksum="831B6476AC05DD58" modified="2010-05-18" version="1">MPTHWELQDTDATTEDSDDDDLGYPSVARVPTKRRSPVQLSNDKPQKRQRPLLESPVTPGRENNFIDLSKTASEGSDDEFNNGEAVYKEFKNRKTVQRKRSAAQMRKRRKIQRDSIVGRRGTGTESRKPARLPREYGDLSSDDDMMEDTLPDYLKRRRTAFDKRREQLVEAGLKLPPNFDDVQFSDDEQLDSLIEKPSFSHVKPSRKYEDVQLPYSLGLIPAPIAQWLRNYQVEGVGFLHELFVYQKGGILGDDMGLGKTVQVIAFLTAAYGKTGDERDAKRMRKMRRKGEYAWYPRTLIVCPGTLIQNWRDEFDRWGWWHVDVYHGDSKDAALKSAASGRAEILITTYTTYRLNRSAVNMVEWDCVIADECHIIKDRKSETAKAMNELNALCRIELTGTAIQNKYEELWTLLNWTNPGKFGPISTWKSTICEPLKVGQSHDATIYQLSRARKTARKLVKNLLPAFFLRRMKSLIADQLPKKSDRVVFCPLTETQSDAYENFLDSDIVDYIKNSSDYCSCGSGKKAGWCCRMFLPQGGKWQSYVFPAISNLQKISNHLAILIPQPMDPKDKQAKDLEMLQVAVPDQWRELYRTRGSIMNYSNPEFCGKWKVLKKLLKWWHANGDKVLVFSHNVRLLKMLQMLFNHTSYNVSYLDGSMSYEDRSNIVNAFNSDPRQFVFLISTKAGGVGLNITSANKVVVVDPNWNPAYDLQAQDRAYRIGQLRDVEVFRLVSAGTIEEIVYARQIYKQQQANIGYNASTERRYFKGVQEKKDQKGEIFGLANLFEYQNNNVVLRDIVNKTNIAESKAGVQVIDFEMEREQSQSDYDGVDDKLNLSTPDENDDLAMSQLAALVRGEGLPEENKKLAPILKHDPIQAILAGAGVEYTHENTEVIGSSKIEAQLSRRAELVNDGEEIGEEQVFRPESREGKPASIQVRGKNGLSATFKYRPPPEVMKRQFCTMAARYGFRDVTEFALTVEGLTSAQRRTWLENWYKERREKLLGGGIFKDSRDPTRPQKAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D112</accession>
    <name>D4D112_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short-chain dehydrogenase/reductase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025100.1">
        <property type="nucleotide sequence ID" value="XM_003025054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D112"/>
    <dbReference type="GeneID" id="9580592"/>
    <dbReference type="KEGG" id="tve:TRV_00758"/>
    <dbReference type="HOGENOM" id="CLU_748396_0_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="370" mass="40064" checksum="1AE0029201FB4A5E" modified="2010-05-18" version="1">MKNFPVFNVLLCPFYIPYPYLSAKAKDGNSSFTRQPTESYGRDLAFFHLQLTMIMESGSSSELADGEIWRSAVFILATKVKKAYSASRIPAASRLLIHFLYLALANEPFLILTKDGFSKAAEREGGCNNGGIDRHRTSVNHLGLDHEQELISTLKQEVADILASESKKISSSRRLITVAGDVSLPETGTDFIRETVSAFGRLDIFVSNAGICEFKEFLEISPTLFDRTTSVNLSGAFYVTQAAARQMALSQSPPGGSIIGVSSISALVGGGLQAHYTPTKAGILSLMQSSAVALGKFGVRCNALLPGTIRTGLNEEDLKDDKKRTYMEDRVPLGRLGEPKDLAGPAVFLACDELSGYVLLVDGGMFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1E3</accession>
    <name>D4D1E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024972.1">
        <property type="nucleotide sequence ID" value="XM_003024926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1E3"/>
    <dbReference type="GeneID" id="9580464"/>
    <dbReference type="KEGG" id="tve:TRV_00893"/>
    <dbReference type="HOGENOM" id="CLU_2456382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056095" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="89" mass="9979" checksum="65B41FB2399F0925" modified="2010-05-18" version="1">MQTADQLFAFFLASLLPLVTRFLINIDCKVEDLVFASSIVLVPTDATRIDIEKPQGEITYVISTDNEMLKDHHHSSCIFLAYSAVFVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1G9</accession>
    <name>D4D1G9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024914.1">
        <property type="nucleotide sequence ID" value="XM_003024868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1G9"/>
    <dbReference type="GeneID" id="9580405"/>
    <dbReference type="KEGG" id="tve:TRV_00919"/>
    <dbReference type="HOGENOM" id="CLU_1983182_0_0_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="14659" checksum="154A5E46220E08B3" modified="2010-05-18" version="1">MVWTSEETQIVVAAAICTLQVLIRSFVRIGGTLKWFPTMQQQRWHADDSWMVASLFPLLLRTVCMSWNFSLEKPLSQKDEELFQKLVMTARLTYAMLAIQILRAFIFLTFIIIVLATLLECRPIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X9</accession>
    <name>D4D1X9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024732.1">
        <property type="nucleotide sequence ID" value="XM_003024686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X9"/>
    <dbReference type="GeneID" id="9580222"/>
    <dbReference type="KEGG" id="tve:TRV_01081"/>
    <dbReference type="HOGENOM" id="CLU_015606_0_0_1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65372" checksum="99B32362E01A8B3E" modified="2010-05-18" version="1">MSGLVSDEVAEDYKNSLEDLTSNDKFQISNLTVIAKENTEHAMAISRVLENHIRNTPPSQKLPALYVVDSVVKNVGTPYTLFLGRNLYQTFMNAYTLVDSQTRKKLDEMLKTWKEPVPGSLDPRPVFPAEITRNIENALIKARTAALQQQQSRSQQEAMSLGRGIGTPPPIWRNTPTPPQGGPRYPPGYGYNNQQMPSNGHGYPNQPLYNQPPQEPINLASLHRDVDSLIMSVRLEFTANPLNTAVQQKLKALLDLQNILQQQRLPDAQLKQIRDQVSQLSASSAKPTPPPPAPAALPAHISNPPVSTPPIGTVPAQAPQPNLQALLNPNTLAELIKATAQKPTPTQQTQPYTQPAAPTPSLAAAVQPPVSLAESPLIASLRARGLLPPATGTPTTTPPNLPFIIPGQPPYAPVPANTNSQGVKIKVPMTSASIRILALQNKSTDKRGSQEKSEQKLVSRRARKFYAVSLDWIKFREFEDDIGADDASVAARKSNNEDASGKKAEQQRWIHAPNDATLRNTPCPICQENFESTWFEEAQDWIWRDAIKVGNRIYHASCYAEVTKDGSTGANADISRGRTSTPDSVLGKRKAEVSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D286</accession>
    <name>D4D286_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024620.1">
        <property type="nucleotide sequence ID" value="XM_003024574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D286"/>
    <dbReference type="GeneID" id="9579946"/>
    <dbReference type="KEGG" id="tve:TRV_01188"/>
    <dbReference type="HOGENOM" id="CLU_1455387_0_0_1"/>
    <dbReference type="OrthoDB" id="4199879at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="192" mass="21729" checksum="5E8CB2B8D58EC7EB" modified="2010-05-18" version="1">MSTETLYARSWGEARIKSQSLNIYTHDIRAASDIALSETKPTTLNSKQRMGFWSKFKRSKSQNINNYHTKPDALPQRAKSDANLVWCPEQKIWLFARQSANNSSLSPQTQRHNSQQKPTATTRLPPPAEYGEEELLFAQLPGHYCLGIYTETNNEPVSPCEPDYFDFSGQKALQTSRWMSVAQRVGPGNAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2E5</accession>
    <name>D4D2E5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000070">
        <property type="protein sequence ID" value="EFE43977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024588.1">
        <property type="nucleotide sequence ID" value="XM_003024542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2E5"/>
    <dbReference type="GeneID" id="9579913"/>
    <dbReference type="KEGG" id="tve:TRV_01250"/>
    <dbReference type="HOGENOM" id="CLU_011451_0_0_1"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="644"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111359" checksum="E0E33F36012F5F95" modified="2010-05-18" version="1">MDEPPASTSNPAAPATSSSPHQQLPQDCDPNRAPVPSIESSADSGDIDPFSPTPPFRDRPRPSRTPGRSQCSDSSPRVHLSTPSTPLGVPTPLSVIGASDLRLPSGSPRILEPEPLWYRRGRTSQVDELRHVLDPPNTPTKLALSPPALRHALSTSTSVTLPAIRAVEAIHSLPSLSTITSAVPAMQNTSDLASTPHQRESATSNAMEDNTSAAAPIAAQSLGPSTVENFCPDARHILSSSPESIKYWEAILDRCNTSTRITKPHIGQRDMFVVGNVTIKSDHLDPSGGSGYHLLDANEVAAVKLVKDAIPGIQVPQTYFNSKIRGHDTLIQSRIPGRPLSDIWPSLTTPQKESFKSQARDIILKLRRITPVTLKYPRYFVAGSEKESQRKLTAEEVHSLSPTDTCEDLGVAHNDMIMSNIIVDNDRIVGLIGWSNAGYFNWRTVSRIHAKVRCVDPKTNASIPEYHESEVPWHDLYEPTQESKRIEIDETATPKVSTPTTELNPLLPSEEGSSQTPALTPRKVADMKRSSVSRASSVDRSSPAPSLNSQPVTKKKGPSAASIKKGTAKRTPAASKKRKINEIGDVEDVKSSPLAKPSTQRYKKQDSQSAAGSPAPENKAPKKARLRRGKLNNDDDDEDVDESALFCICRKPDNHTWMIACDGGCEDWFHGRCMNIDPKDADLIDKYICPTCETKSPLRTTWKPMCRLRECRQPARVDAKPPSKYCSDQHGIDYMKQAMSRGSRQPSSSADEQSNRRHKNEASRGGILNLGELKSVVSKVDSADQFRKLGASPLSARQEEVQARLSDAMASPGPNQSDSETKDVNFDSEADKVAFSSSERQRLNQLRKEKLRLDNRKEMLQARDNFIVISKQRVKHAFDRLKAHGSIGNLQPKDICGFDNRFSLSDEEFDEWRKSEKGALLLADFSAQDNAGEASPQLKSAVDAESVEELLQTLCLKKRCERHKQWTKVMQQEVLFEQSILREQSDKCHKDAEELVKKAVLRMFSNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2G8</accession>
    <name>D4D2G8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024561.1">
        <property type="nucleotide sequence ID" value="XM_003024515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2G8"/>
    <dbReference type="GeneID" id="9579885"/>
    <dbReference type="KEGG" id="tve:TRV_01273"/>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29398" checksum="7E9D991312A3F4B4" modified="2010-05-18" version="1">MTSLIRDEAKENYGIFRECVSKSILSRSMERSGMARRKRNRKRHARTSFNNTSFPDDNDPAELAEFIDFIAQEIFRSFPEEVQTLSYNAIQSSPVLADTYAECISGNTIDFLASLVDQSVSESLVAYSLMSEASDFTAMLSSVFMEYSSTVTAKPPPFSATRTSACEICERDWIPLTYHHLIPKAVHSKALKRGWHEERDLNQVAWLCRACHSYVHRMASNEELAREWYTVEAILEREDTQEWAKWAGRLRWKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2K0</accession>
    <name>D4D2K0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000072">
        <property type="protein sequence ID" value="EFE43926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024537.1">
        <property type="nucleotide sequence ID" value="XM_003024491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2K0"/>
    <dbReference type="GeneID" id="9579759"/>
    <dbReference type="KEGG" id="tve:TRV_01305"/>
    <dbReference type="HOGENOM" id="CLU_012842_0_0_1"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="572" mass="60342" checksum="7008D26EEF3DE2B7" modified="2010-05-18" version="1">MFGVGLGPDGKPAHFFEGSLGPVPQAYGHPPPQYYQPQHPQQQPNPSYGNVYYAVGHDAAHQASYESKKRGYDALNEFFGDLKRRQFDPTSYAAVGQRLLNLHGLPLPLTHGGAVPEYQPMPAMVGVGGGHSGYQSAGPIPTQSYHLPPMGNLRTKADLMNIDQFLEQMQSTVYESDENVAAAGVAQPGAHYVQGPLSYRTTNSPPTHHQSHHHPHATATAATTTPAATTASMMSTSAAVTPASSVSAASRSPLASTPALTPPSSAQSYTSGRSPISLASSHGMSPSHHPSTAGMYPTLPATTGQDSLSSSGYPTTVSSAAPPSTLSSIFDDDRRRYTGGMLQRARPDIDLSTPSIKRDADAAAAAKDEAKLSSSVIDPALSRASADMDEDAAPRRSPSSTPTPTATTAAAAGPDDRQPAGEQQWVENVRLLQRLRDYVLERLNNGDYVDEDKQDDSDKEEDAKTDKASPGSASTTSASDAATGAGEYPSIKMHGMEAIAAAAVAHEEGRDSQMPRDDEDQENPSTPTARSTTTMLDAEEEAKQAGENLYPVLKMAVDDDGADTDGDEKMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2M2</accession>
    <name>D4D2M2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024497.1">
        <property type="nucleotide sequence ID" value="XM_003024451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2M2"/>
    <dbReference type="GeneID" id="9579720"/>
    <dbReference type="KEGG" id="tve:TRV_01328"/>
    <dbReference type="HOGENOM" id="CLU_082502_0_0_1"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="236" mass="24030" checksum="3C9D94D9598DDC1C" modified="2010-05-18" version="1">MSNPFRNGGVKNESAGPVASDSLAAESVREQGKFGENKNSQPLGVKGSHSTLANTDTSSASKLQAAPDAEARLAEAEWGEGRPQTRSQTQAQSQGQTKSLGDEQQQRERQNQGQGSNETSGASSGATGSGQGDGPGSSLNTAPHYVDPVLGSGQASKPKGKNLKEGGFGDDPARNASFNADIGSKKDPGLQAEKEIGTMSAQNAPGPISKGGPDLMGGSERKTGASYNVLGSEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2W1</accession>
    <name>D4D2W1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024454.1">
        <property type="nucleotide sequence ID" value="XM_003024408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2W1"/>
    <dbReference type="GeneID" id="9579676"/>
    <dbReference type="KEGG" id="tve:TRV_01417"/>
    <dbReference type="HOGENOM" id="CLU_3160283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="48" mass="5016" checksum="6C3F4F21EB265A14" modified="2010-05-18" version="1">MAPLVQLQRLAGGDDGAAVAVLVVFAFPEVLDGAVVAFDNHPPDVYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X3</accession>
    <name>D4D2X3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein (Sec66)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024466.1">
        <property type="nucleotide sequence ID" value="XM_003024420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2X3"/>
    <dbReference type="GeneID" id="9579688"/>
    <dbReference type="KEGG" id="tve:TRV_01429"/>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27388" checksum="18F7352D310BC85C" modified="2010-05-18" version="1">MLDFLKIDWLSLTIPLAYLAVLVGSLATFSSLYRKRKIQKASSLKPWFPAHLQRDIYFSILHMEKKAPETILKAALLHRAAEDIKRLLELRTKKAALGSLLQKGNVGDDLWQQFTRAEKEMEEEFRDVASEANAYTPGWGQVIFQSANEMFLNGMARADINALQATVTEEKEWWDRKRASIQEGFMKELEQEKSGTTESSKTKGGSTGDNTQPGSDEDTVLVDVASSTGSAAGSVSGGGKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D307</accession>
    <name>D4D307_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024397.1">
        <property type="nucleotide sequence ID" value="XM_003024351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D307"/>
    <dbReference type="GeneID" id="9579619"/>
    <dbReference type="KEGG" id="tve:TRV_01464"/>
    <dbReference type="HOGENOM" id="CLU_017407_0_0_1"/>
    <dbReference type="OrthoDB" id="5402147at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="652" mass="72917" checksum="B2CE35DAC3BF22B9" modified="2010-05-18" version="1">MAFRLPDQTPQRQHPYRGSGRASTTPPNVPQPHARADEEDSQEWVLFSPVEAQSTATHSHTASTERTPRTAGLSRLSDFGSLETAAQSSGPLYSEGNDGETEDQERQLQDTGLQEDDVTELDSLDDGLQAFRDPQLDQSGGPAMLPTHDGLGTFSPSGVNVQEQLWQHEQFNPRRIGETRQRSSSSVRRHLDNANESQPMGIGMERERWQRIEQWRMEQSKVLLQEIEKETRRRRQRKQRAQSKGSDTMHPLRSIVSEDTTSKTDASLTASQAALDATVDATPSDETDSDESFWQRITRRVINGLIGIDDSLLAVIFGESLVSDTTDSDTNSTSPQDQPGSSFAGNRYLRATTLATDSSVNMGETIPNIMSSSTRDGWWQERLLERIARELGILVHQIYEHPGAFTAYMRTNIDPSTEYAGMPISQPTATPTVSAMTSRRESHSSHENTTSVPYPTFHPTMQDAATSRHAALWGIEEDVPAPRDAEPSHILSESERRERDREYWERELNIKMVFRYLRNRFAATATGDASSTQDNSDTIELTTPQHRAQRQRQHDPIRAAIIRQHHPLVARAEANSRFRQQSSRIYRHQHHHHHHMRGTISPSCASQSQSTRKSVSTKRTGSSRHYWDIGGSAGSSSAPLAVGGGMGSWGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3A9</accession>
    <name>D4D3A9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024289.1">
        <property type="nucleotide sequence ID" value="XM_003024243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3A9"/>
    <dbReference type="GeneID" id="9579409"/>
    <dbReference type="KEGG" id="tve:TRV_01568"/>
    <dbReference type="HOGENOM" id="CLU_2644904_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="77" mass="9133" checksum="0512B732AE9B4DE9" modified="2010-05-18" version="1" fragment="single">CGGDQEERQDSKKKKKKKKKKNLPTEKKKMDEEEKKREEEIARGKRPGRLFRLAEEEEEEEDDDNQDDSNGDEEDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3E3</accession>
    <name>D4D3E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein S11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024252.1">
        <property type="nucleotide sequence ID" value="XM_003024206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3E3"/>
    <dbReference type="GeneID" id="9579372"/>
    <dbReference type="KEGG" id="tve:TRV_01603"/>
    <dbReference type="HOGENOM" id="CLU_072439_0_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="312" mass="34503" checksum="074AD836CDA687E8" modified="2010-05-18" version="1">MSGRIPLLTALRSLALSGEAQSYSSRSLLRRPFSSTAQCRTASKDTQTQSKNDRELENRLLGGQSKNAGPSRLATLSQTTRSKAAASSSSKTTEEVISRVSSLIQNPQRTTELPHRLHIYSHRRNVHATLTKPNNDVLMSVSTGNIGFRKGHRGDYDAAHQLAVYTMGKIQERGFLMQINGLEVILRGFGPGREAFTKVLLGKEGKVLRERIVRVSDSTRLKFGGTRSPALSLASFLFYSLDSVATLTLFFMMAPAVPAVRVNDLCCFISSQAQDKQQERKEEKLNFKQPQAGRQLDSQRTTDQLKATVSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3F6</accession>
    <name>D4D3F6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMG box protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024265.1">
        <property type="nucleotide sequence ID" value="XM_003024219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3F6"/>
    <dbReference type="GeneID" id="9579385"/>
    <dbReference type="KEGG" id="tve:TRV_01616"/>
    <dbReference type="HOGENOM" id="CLU_048021_1_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="33985" checksum="996F1338C29D8FFB" modified="2010-05-18" version="1">MVFKLAQCGRFAVRRFNSRVLYVPSSGLRTEVIASSFAARLSIEGLFRSLSLSNSYATTAAKPKTKAEKTVKKKKKASKKPTPPPKRGRPGKSNKEKRAEEKKKEAKVRAREDLENLKEAALTPPKPLPTSKIAIFSSGKGPLAESVKAFKEISQFHVDELGQTAEKNAETNRHNLEQWIESHTPLEIKNANAARRKLRRILPKKSRIYGPIKDYRQVKGPRNAYLLYSLDMHNSGELRHLSAKERIAETARSWKNASESEKEKYKSLQEEDRKRYINEYKSTYGEEPKLVESSDAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H4</accession>
    <name>D4D3H4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024201.1">
        <property type="nucleotide sequence ID" value="XM_003024155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H4"/>
    <dbReference type="GeneID" id="9579239"/>
    <dbReference type="KEGG" id="tve:TRV_01634"/>
    <dbReference type="HOGENOM" id="CLU_1887258_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="13553" checksum="9FD4CCAB1FA68541" modified="2010-05-18" version="1">MVNELMAGDWLIGGERDGEGVSGLNFSLPVEGGVGELGGAARAAVDAVGTVVVVAGSAAAAVVAVEIGSGSKTARPQAGTGRDHLPFNEADETEDVCWRAVEGVAGVAGVAAAGVRTERRAAWREFELAVFVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D465</accession>
    <name>D4D465_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023938.1">
        <property type="nucleotide sequence ID" value="XM_003023892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D465"/>
    <dbReference type="GeneID" id="9582631"/>
    <dbReference type="KEGG" id="tve:TRV_01879"/>
    <dbReference type="HOGENOM" id="CLU_009650_0_0_1"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="90090" checksum="A588B1E71D531611" modified="2010-05-18" version="1">MAPRSTSGSSRASSGPRIKIDTEKYSPYDHDEEYGSHSEFSYATSASESSASRPFLSQSKYRRRPGVRLYRVPNSIMRWVCLGVFAGLVLFVFTLFRVTLSQAIFKIPAPPPPNIFKPQPPEWESFPFLLRYYGGLRTLTPKNESAPEYPGENDGQDNSTAEEPIDMDRVVKSTPFNPYPEFSSKSYVEKYGRKVDCFMDPERKISVPQVHRYDGLPRGFPDSVIGSNELIGLETNACYDRFGRLGPYGLGYGVRSGGTGAGLEGDRSGVDHMWENTSPVDYRKVKWAKAQKQCLHDNRHRFPLPPAPKTDRFLGMSVGEKTPRGAEATQNGAPKNATTPSTTKLPRTAVIIRTWSEFKYDTETILYLRSLIAELSLFSGGEFDVQFLIHVKDDNLQIWSDEDTYNRVLQESLPEEFQGMGTLWSERQMGLIYGGLEESFARNLPVHGVYRSTFMPVQYFALQHPEYDYFWNWEMDARYTGHWYDLFNKMRLWAKEQPRKGLWERNSRFYVPSVHGSWEDFRHTVRVQTEHGTASPNNMFSAASKERPNGHRPTEMKGDRPIWGPERPPAENDVLELEDDGIPPTTYEKDKFEWGVGEEADLIVLNPLYDPDGTTWLLKDDITGYNKSEESPPRRAAIIAASRLSRKLLLTMHKETSLKRHHMFSEMWPPTVALHHGYKAVYVPHSVYIDRRWPTAYLESVFNAGRNGATGGARTSVFGNREHNFRGTTWYYSAGHSENLWRRWLGYRSNNDGGEEYELANEGRMCLPPMLLHPIKEVNMVIDSAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4B0</accession>
    <name>D4D4B0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023875.1">
        <property type="nucleotide sequence ID" value="XM_003023829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4B0"/>
    <dbReference type="GeneID" id="9582624"/>
    <dbReference type="KEGG" id="tve:TRV_01925"/>
    <dbReference type="HOGENOM" id="CLU_008913_2_1_1"/>
    <dbReference type="OrthoDB" id="5380370at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49512" checksum="4DA1BA15C8A8B4C3" modified="2010-05-18" version="1" fragment="single">KPSAQLQTAYLTAQADSEWFQSLPPKVQQRHFSVEEQTRLGGWRSSIILDAADQALYKFGSFTTAAESSLSLPATATLSRSSSFSSMSSAVDGDAHHHHNNNHNNNNNDDNNQNDDSLYDSFKWLDEEDEIDLSLDYHAHLAETSASSANLHSKKSPFRSRRQSSFRRTFSISSGSNRGRSSGSGLPSPRLRSQTAFQPNSISSSSSSSNNNNNHNLRPHSVSRPTPPPLIPPYLPHTSHGSVDHPAQFYQDPEARLKLRVYLASPQKFDEAIEFGFPSLEHNDNLGTPFSFDRKWKMQESPTSSSFIDSESIAPFDSTASASGPPSPRTAVRPKTSGDLKPDSNQSASTWRNPSVCDSVNSRPSCSSRRPIIVGSSGPMGSREMTLKMTLTRPDLRSSELTSSPKSSMTAEEDPLKLADLPVDEKAPVWEKPEKTSMKSVWRKITGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q2</accession>
    <name>D4D4Q2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000107">
        <property type="protein sequence ID" value="EFE43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023793.1">
        <property type="nucleotide sequence ID" value="XM_003023747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q2"/>
    <dbReference type="GeneID" id="9582367"/>
    <dbReference type="KEGG" id="tve:TRV_02068"/>
    <dbReference type="HOGENOM" id="CLU_2446837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055575" evidence="2">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="90" mass="9360" checksum="EE30AFD43D201262" modified="2010-05-18" version="1" fragment="single">SSQPGLALALALALALALDHSPYPVRLSSSCLPVCLSVCPSGLHSLDICFDICFDICSANNSSSNHEHVDAASGQPWRNTGETAAAHREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D512</accession>
    <name>D4D512_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02181</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023673.1">
        <property type="nucleotide sequence ID" value="XM_003023627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D512"/>
    <dbReference type="GeneID" id="9582220"/>
    <dbReference type="KEGG" id="tve:TRV_02181"/>
    <dbReference type="HOGENOM" id="CLU_010480_1_0_1"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.60:FF:000006">
        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="837"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="875"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112549" checksum="02AD09FCF1C1C135" modified="2010-05-18" version="1">MSTPIYEGAQPKYNTGTASDEQPREAEAGQQYNLPVEEDMVDDKGNRVQMLVEPPENDEHGLLNTTPSQDREKANRLNDDITMLQAERMVSNAEASDIERSLSIRPARSHRTEPVDEFDTATNPIHEHASLYKPPENPTTSIARFFKKVHESSFLVRYFTYIIPLVLIILIPLLLGAFVFKDATVGGVSLLWFSVWLEIVWLTLWAGRIVAKFLQYPVAIIASLFTNNSKKWRDLSAQLELPASLFFWWLSIEISFLPTMITHHVDGDRTVKRWEVIVNKIIISIFVGMTLNLIEKLIIQLIAISFHLRTYADRIEINKFQIGSLAKLYAYSREHTTMNDSDLEEKSEKRSSGTRTPMMYADRAQRAARGALSKVGDVAGAVAGDFTGRRVNSSRDPHQVVLTLLRSTSGSQVLARRLYRTFVKDGFDTVFAGDLKSAFDNNDEADAAFQMFDKDMNGDISMEELEAVCTETGKERKSITASLKDLDSVVSKLDDVFFFIVVVITILVFLSLISASTAGVLTSAGSTLLALSWLFSATAQEFLQSIIFVFVKHPFDVGDRVSIYGNTGANLTGDDYFVKEIALLYTEFKKMQGHVVQAPNSYLNTLFILNQRRSGGLAEAVPVIIKYGTTLEQIDALRQRLLDFVTSEKREFQTQVLTELKEVTENYSITLNVVFFYKSNWQNELLRLQRRNKFICNLMICLQELNIEGPRMNLVGYRSDLPAHIAHQGAPPQYTTTPVYGANTPGGMTDVSQTSEARDALGDLASSSAVQPPHHTQSILRHRDRSGTTASNRSQTSTHKRVDFSLGMKALSSDDMISDVYWDRGHRVEDIVRSTNLEAAERRQQEKDSQERANAPLERTPTNLRSSNDSHRPNFSQSRGSVSSSVYRSRFFGRMGSGRGTPSRSRTRDGGGRYEDLEQGRYHASVADEESGPASAPTQASAPPAPGPDQPRTLDPRSGSVDTQGMYDDGQTQGTMWSAGVERHPTHGSERPLDESYELPNYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5C8</accession>
    <name>D4D5C8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023551.1">
        <property type="nucleotide sequence ID" value="XM_003023505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5C8"/>
    <dbReference type="GeneID" id="9577023"/>
    <dbReference type="KEGG" id="tve:TRV_02298"/>
    <dbReference type="HOGENOM" id="CLU_002369_1_0_1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="354"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119629" checksum="B919FF7CD7FB2078" modified="2010-05-18" version="1">MLIVDLDKGTVVEKIPAEANYTIMKKSRHLCAATDAGSVHVLSLTDYSLLKSWKAHGAVINDMDARNDFLVTCGFSVRHIGTPIVDPLANVYDLKSLTPLSPVPFHAGAAYVRMHPRLQTTSFIASQSGQLQVVDLMNPNSISLRQANVSFMLGMEISPSGEALAINDAECSVHLWGSPAKIHFNEMSKETEFPDVTPRPPMLDWSADTPLNVIGMPYYHDRLLSAWPSHLVFEVGSIPKQVDPAIIPYLHPSDMGQYAPNPRKTHRYQVENTRCQPTTETALAAPKFLSEKARAHTKSKSLGDKEPLDDLDGLKINGEAENDPLLKYSNVEIKYSKFGVDDFDFRYYNKTNFSGLETHISNSFTNALLQLFKFIPLAKNLTLHHAATNCIYENCLLCEMGFLFDMLDKANGQSCQATNLLKTFSGFREAANLGLLEENLSNKSLASTIQSVNRFFLNQISNDYRLLYPGSDQLDQVLATSAIESVRCMYCRNEIVRAGNTFVSELIYPAVDIKQAARNPACRFSNILRASIEREAQNRGWCSTCRRYQQVAIRKTVERMPMVLMINAAINNPVCRQFWSIPGWLPEEVGIITDGKQMRCFEGAELQAQKREKTPNLLVYQLVGLVAEIDVVEQKKPHLVSFIDVAISATTPTEESKWHLFNDFLVTEVDKNEVLSFKQPWKQPCVLSYQISTARHGVDDSWKNALDTTLLFYEWSMNNCRPIESCQVLKPDEKPTPGTAIALDTEFVDLEKAEIEVKADGTHEMIRPSKSGLARVSVIRGNGTLESSPFIDDYITIKDPIVDYVTQYSGIKPGDLDPRTSAHNLVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKINIQVPKAQTIDTQYLFFHPSKNRRLSLRYLAWAVFKEYIQEENPSPSPKTSAATPDIPTSNPTSTPATSTAEGHDSIEDARMALRLWKKFQEYEDAGIVNQMLEEIFREGVKHGFRPPPRHQPQSAGVPAYQPSSSGLAVYNHKMSGPVTAASLSSPPSGRNTPDAGPGGGALGTNGGVGDNPPTTPRQMFRRSTALTPTSSSYSGAVGKYPMFGGSPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5G6</accession>
    <name>D4D5G6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023589.1">
        <property type="nucleotide sequence ID" value="XM_003023543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5G6"/>
    <dbReference type="GeneID" id="9577061"/>
    <dbReference type="KEGG" id="tve:TRV_02336"/>
    <dbReference type="HOGENOM" id="CLU_051875_0_1_1"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="257" mass="28825" checksum="82728CF0DA9BA7D2" modified="2010-05-18" version="1">MREDAEEEEQEFEFRLFSSVSTRKTADESRSRTEGHDGSGLGGVQKLKIRLRSPSPSACPLGDGGFVVPFRGWDYYFSNPELVMRAVGDTSWQRGAKDKNTSKQLDALRYTFRDTAVDGEAILARAASVAWPGCHLPWRVVHIPGPKVKSASSATPTTKSEPSLSKKKKKPGKKRRIALRKRVVIKKMAEETEKEKRNRKNRERKVKRRQKEREKKAAARAAAGEDEPTVLAASDTAATAGETIDKSREEKKEKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5H7</accession>
    <name>D4D5H7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023497.1">
        <property type="nucleotide sequence ID" value="XM_003023451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5H7"/>
    <dbReference type="GeneID" id="9583534"/>
    <dbReference type="KEGG" id="tve:TRV_02347"/>
    <dbReference type="HOGENOM" id="CLU_1424750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="20554" checksum="A513D497C5EBC7F4" modified="2010-05-18" version="1" fragment="single">KTQRLHGDVTGGRQGARQAGYSVLYALSYTAVLAAARDGSRSQPQVRPGDIIDIIDTTMKKAMIRLGDTPCCERAAAGLILAVFRPCRLTYGAYGGLPNTEYGVCIITNLIMAVCSLTTTTAAFDTARAAKEELKYVTATATALKSPNQRPQRERVDSAGGCQPPGFNPWPAGTQYQRLFSRHDLPSQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5I6</accession>
    <name>D4D5I6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ring-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023506.1">
        <property type="nucleotide sequence ID" value="XM_003023460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5I6"/>
    <dbReference type="GeneID" id="9583526"/>
    <dbReference type="KEGG" id="tve:TRV_02356"/>
    <dbReference type="HOGENOM" id="CLU_031806_2_0_1"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="48952" checksum="485552B46540D189" modified="2010-05-18" version="1">MAMQYMKSIRRKPVAKTESTPTPATETHGPVLTDEDEAFLHHVATSSSISGSDSGDKKPGGSKDEQGRELVDEPLDDDLRRLAEDRGSQEKLDAPDTEPTATTASSVSTDQKKMEKGHKSRKSLWGMLKDRKWMGETEKVDKGKGKVADDTQSSGEGAGKGKNEEERKEDQDLSKVLEQLNLAAVNNRVFSISSDTQALLEQFKQVFKDLVNGVPTAYRDLESLLTNGDQELQKSYTKLPSFLQKLVEKLPNKMTEKFAPEILAAASARASKSGINMQHVDKATSTAKKIGIEVPNLKELAGKPAALAGLLRSIIAFLRARLPALIGMNVLWSLGLFILLMVLWYCHKRGREERLAREASMAGEGEKAEGEEARVIDVTDEASPSTTPAAVGAPAAATGAVANTESDAQLTRQVEGQVPAATTQIEAPTTATSEGAATDKEPRQTKEEGNVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5K9</accession>
    <name>D4D5K9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023487.1">
        <property type="nucleotide sequence ID" value="XM_003023441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583507"/>
    <dbReference type="KEGG" id="tve:TRV_02382"/>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="696"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="877"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1369"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1661"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1986"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1586"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2359" mass="261567" checksum="ACA6655CC5470107" modified="2010-05-18" version="1">MTFPSPSHSAQSSIASGSDQPTTARSSRLQPSAWGVPSSQASVRRPLTLATANLSSSTGTSSPSRRTPAAGAVASPSHTSNPTPAPGPATSPLTSTFSAILSSGSRLPAARGNPSPAATPSPFASSFQAGAQHPSQQQSQQHSITSPKSTTPLPPSAVSHLATPTASAPGGGGSGGGGGGGGGGTAVSRGATFSPLLTGTAVGSPTGFPSDKPSSATVSSTGGAGSSQSSLSKISVVQVFLLLDSINEKEGKEKWETKAAQIHRLVNSNGMEVFSKYFRRLLSSNAGQIFSGANKNVDNSGNYPLLVQEVQKVALDPDQGRKIAETIDTSEGDIFRDFDLSTFLDHFKLDPILKTALTLAFKNVTKSDLRTKADAILSASLPQFLQSLSTISDSNKDSTPSFIALTIERLIFNPPRNFNEDMKKKLIYDVRIRYQNADSEVPIEVDSALQMFSLTDPRLSLVRQIQARGPQSLGDPDTMLDTIKAAGSDAFSGEQIGNAILFIVLSQSWQQYPLDLLVSTLLKQHASQPINWPEAVRQFDKDGLRVDNSQFARIFNALLPVAQEDNSLDLQMLWGGDWAHKNAQFSFLTAFLCAGIDTPGIDTSQIPNFRSAFSSDIFDDASETVKLQAEQTKNNPLRSLDATKAIFDLILVSPATWALPESQNFVKTILQHDLPTFLCSAFAIPQPWTNVQHNFLVRSFMIFILKRQDGYQFALHGVWKLNQQWVGEQLFHAFTQDPSCTDLIYEHAVEHGWLDYLLDFTNGLAMDLASLAHQKGSFDLEQWVKGTAGKTPVDMGGLLAKFLRIKAEDELRVQRGEQPTPQMVSLSVKTVFALLMILEDYITDHENLTPIQRICLQTYPRLINYGEGFDDVIEANSVRGNAIPEDIDKKMRDLFGKMYHEELSLREILELMRRYKSSREPAEQDLFTCMVHGLIDEYHCYHEYPLEALTKTAVMFGGIINFKLISGIPLKVGLGMILDAVREHEPHESLYKFGVEAIEQLISRLPEWVGFCSLLLQIPSLQGSNIHRKAEEVLREQGHHPINGVDGTEANGVTDGLSLANGSVNELVNEGSPRKFQSLHVGPPLRPDIYKEPDEDTHDKILFILNNVSEQNIKSKLQDLRESLKDEHHQWFASYLVEERAKLQPNFQQLYLDLLELIDDKTLWAEVLRETYVSSIRLLNAESTMNSTIDRTHLKNLGGWLGSLTIAKDKPIKHKNIYFKELLIEAFDSQRLTVAIPFTCKVLSQAMKSSIFKPPNPWLMDIIALLIEIYHFAELKMILKFEIEVLCGDLELDHKTIEPSTCIRERPAQLHEGLPVACLPEGLEAFDDMSLTGMSRGIRADRISPSSIISNLPKLDQILVFPPSADPNTLKQIVHGAVERAIAEIIAPVVERSITIASISAAQLILKDFAMEPDEEKVRQAAGTMVRALAGSLALVTCKEPLKMSMTNYIRMIQQEYSDQPMPEGLILMCVNDNLDAACGIVEKAAEEKSLPEIEKVIESQLEARRRHRIARPNEAFIDPSMSRWALFIPEPYRQVPGGLNKEQLAIYEEFARQSRGAGPTHIQHASTDSGKQIPDVLQEAFPGMPNLSTPADQSAIPHPASRGPQDADVQQQALAGTQPQINGFLEASTPREKIDGLVVELQHTTRSEKDEHIKDIARDSPILHAYNQVLRAILSSQNGEELARMAAMKICNALYTQTEKTLEIEVLVHLLTKICELSSLVARYVWAVLAEVDDGQMFNVPVTVALIDAGLMDLHRIDMNIAKLIKDKSHAALELLSALMNRVLLNDEPSALRSDFSGSLDALNQWVVEEPDLPLAREIIQTLRESGIPESANTLLSDLARSKRDQMEYIFSEWIGVYKFPGSNDRMYSAFLKDMHHRQVMNTQEDSALFFRLSIDISVAMFEHEYQNVSGNIDEAFLYIDALAKLVILLVKFQGDADGAVKASKSAYLNSILSLLVLVLNHHQVMRGDSFNQRVFFRLFSSILCEYAASGLAQTDQHKGMMLAFADKFLSLQPKHVPGFIYGWLSLISHRVFMAEMLTLDDQVGWEPFCEIMQVLLSYIGEQLKSASVTYVAKDIYKGVLRILLILHHDFPEFVAENHFQFCTVIPTHCSQLRNLVLSAYPSSFQKLPDPFRDGLKVDRLEEMSKAPKITADIVTPLQEAMIKAPVDNALRNFNTADAAIQQISEIIYNPPARDTGLFFNPINVNTVLLEALVLYIGQSAVSSSAQKPGTASFSNSPALGFLEKLVNMLRPEARYYLLSAIVNQLRYPNSHTHFFSFAILNIFGSETAAQHETHIREQIIRVLLERLIVHRPHPWGLIITLQELLQNGNYSFFRLPFIQAAPEVWRSYNYPVHMAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T3</accession>
    <name>D4D5T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023354.1">
        <property type="nucleotide sequence ID" value="XM_003023308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T3"/>
    <dbReference type="GeneID" id="9583374"/>
    <dbReference type="KEGG" id="tve:TRV_02456"/>
    <dbReference type="HOGENOM" id="CLU_066882_0_0_1"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="32124" checksum="422E6C875D6AC664" modified="2010-05-18" version="1">MNPRPKRAASPPIEPKPSRLKPFKNRDGLGAYIKDPESFSASTVVSHSPEFVVIHDLYPKSAVHLLILPRDPQKFFQHPFVAFEDTSFLESVRQEAARVRKQAASELRRKFGKVSALDRKRNEALDADDDGDENTVPDELPEGRDWEKEIIFSTPFFVELDAFPLAEDDKRRHPDREGYLKSDLKCWRCGRNFDNKFTQLKAHLEEEFEEWKLTPKLHTKKEEDFVKKVSDAGSLTKNEKNRWTGRPYLEAQGRKRSEYKGIRSVRRLQGNKNKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D626</accession>
    <name>D4D626_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023323.1">
        <property type="nucleotide sequence ID" value="XM_003023277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D626"/>
    <dbReference type="GeneID" id="9583343"/>
    <dbReference type="KEGG" id="tve:TRV_02549"/>
    <dbReference type="HOGENOM" id="CLU_011098_0_0_1"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="619"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="79016" checksum="4A10CC54ECB39F22" modified="2010-05-18" version="1">MLEPLELRSYPSCDNCLSWSADGEIAVASGEIVYVLSPKPNREEKQQDQAAQRSSGAQWDISKLKTNAFTLDELPLLLPEPGATFSIGEEQSMSHAIAVAWSAPRLAAYGKCMLAVLTSNLALSLWQAVDGASKWNRALVVNHALRKYFKTLTGDNGPLLRRKQRIRAFSWNYFAPNKFNDPDSCHNSGINFLVVSNDTNDIVILRVTAPSYGQSASAVVLTHYSASSEGICLSRSIEQGSVFSEYTAKRATITRVSSSTWLNKPMLGDHGAADLRIWSSLIAFMFGSELAILRLDLDTISMNTEITIKRIELLNLEWTLDYTTTDRDIKGPLHWIETAETSHNLGLAAGIICGFVILTIPKNIWSESILRVDIHEEKFDASLAKWHPISGFTSRVGDTSNSSDLYILTLSSLHQLEFPSMRSKIQPLSNGDKFSQDDYLRRNVEGCRDRFDLDYDLGGMSTAKTWGLCSHRGWIATCATFHPTDMVQHTTSSQERTTILFAPPSLARSDHTELGLPWHMPAITPSSIQHSAGKVIAFTLANKQPQSPDDLWLRKLLYAAACSTIFHSALESSSHAKEVLQYLAHESSLDLGLEISLLEDLAEGSNKLNAVTIPPKSSEQLESNGAGIFEQCDICGGGIEWFSPVESQCVGGHLFARCALTFLSIQNPSISKRCCRCGRECLDNTSEALGIEGTKGLLAKLLERFDECPYCGGKFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6V1</accession>
    <name>D4D6V1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosome biogenesis protein Mak11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023007.1">
        <property type="nucleotide sequence ID" value="XM_003022961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6V1"/>
    <dbReference type="GeneID" id="9583027"/>
    <dbReference type="KEGG" id="tve:TRV_02828"/>
    <dbReference type="HOGENOM" id="CLU_030368_0_0_1"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60454" checksum="2EF7A98ADC5DF62B" modified="2010-05-18" version="1">MRRSDEMESMAVVVVLMAAVGGRRFFCVKFDKIASFLLFCCFSRCSKKGGRRRYGEEEDNIKRKREEEQAKVPAEKREKMARRETTVQIVAGSYERVLHGINATISLDEGNSKGQTEDVGEGEDQVKFTDTFLFQAHTSAVRCLALSPMPSADNKQQQNVLLATGGTDDRINLYSLSVSPMSADTGLVPLPSLAGNKVLENPRNRELGALMHHSASITAMHFPTRSKLLSASEDNTIAVTRTRDWTVVSSIKAPHPKTQGRPSGDTAPVGGAPAGINDFAVHPSMKLMLTVGKGEKSMRLWNLVTGRKAGVLNFGREVLTAAKEGKWGTGEGRKIRWDSAGEEFAVAFERGIVVFGVDSVPKCRVATSPFTKVHHISYLDIETDDEKKQLLVASTEDGRLVFYSTASDSLEELVEGGDTTIPTAPFLFQLGGKAHGQSSRIKEFEILPLQENSKTIQFIVVTSGSDGALRIWTIKPEEIQQTKQVKRGKPSKSGQPVQVGRLLVAYETGNRITCMKAFIMREPIGEEELSEGDSEADDDDEDEDDEDSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D796</accession>
    <name>D4D796_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022895.1">
        <property type="nucleotide sequence ID" value="XM_003022849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D796"/>
    <dbReference type="GeneID" id="9576933"/>
    <dbReference type="KEGG" id="tve:TRV_02977"/>
    <dbReference type="HOGENOM" id="CLU_118853_2_0_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="103" mass="11545" checksum="AA2E42E8E0DBFF56" modified="2010-05-18" version="1">MSSPEFLAAAEASRKLLAKPSDDELLTLYALFKQGKQEPPFDQAPAPGMFDLKGKYKYGKWKSVVEEGVTPEQAQERYIELVEKLKAKYGYDESKQPESVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7E4</accession>
    <name>D4D7E4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022802.1">
        <property type="nucleotide sequence ID" value="XM_003022756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7E4"/>
    <dbReference type="GeneID" id="9581526"/>
    <dbReference type="KEGG" id="tve:TRV_03026"/>
    <dbReference type="HOGENOM" id="CLU_076656_2_0_1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="111" mass="13464" checksum="C8F42AC4F737D27F" modified="2010-05-18" version="1">MATGQVSFHNPKLTRKVFVPQRQNPIVNRLNKTRVEKFPDLRAEKEEYLAQCRKEERKAREEKKALEKKERRERDELRWQKEHAYDDLMSPESVQQSNNQDRGEDFLDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7K6</accession>
    <name>D4D7K6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022792.1">
        <property type="nucleotide sequence ID" value="XM_003022746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581469"/>
    <dbReference type="KEGG" id="tve:TRV_03088"/>
    <dbReference type="HOGENOM" id="CLU_001772_0_0_1"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="757"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1546" mass="170103" checksum="A948CB465E771671" modified="2010-05-18" version="1">MLLSLDQFSASNAADCSFDDSLPYDSPHQQQESFSAYSSYHHHSNSNSNNDNTITGSASGRNTGAHSTRINNQYNRGGENTRYRSHTLSSSVSSDVETYTQHGEGHRLQTNHWSNSRGYRSNSNPSKQPTIRHVDGGSEAERSSYRSKVYDSQRAVGSNDRSQGRTTPRFVRRESTGSASSSVDLNEMLATTSLYGTRRSASFDYGSTLPSRANGRDTSFGHRDTMMQYDDMNAAPTPTVLLGPRKEFAPPVLPDHASIVHSSTPPDTASRTPTLAHKNSTRSARSMYSRKNKSDTLGTSTIRGRSDEYNKYFGDSQDQIPPVPTLNQPSAPSPTIARSKQPLPTNFPVESLNTPPSKERQGFFRRVFGSSRQSSPSQQPDLSPHSTRDNESDPSKQDNASNQPRPYRPSRLPSDPSTVTNSNSTMRENPPVVTKKPSSFFRRRKKSVVENTPPPMLPLSNLSSTDVSKPESQGPEKLRISTATDSIRTDSLSKAMKPYLSDMDSPKQSPKNSPRESPKPSSRGGRKSRDRQETDESDMGSPRKREKPRVKEAEIESAKKLQKLGYLPSSKHRRTTGASKTKSSSRSHSRATNYDGSFLADSSGNEGLSSRQSGDKRSRRPQTSPDPPAQQSDHSTPGPKHDAVLSDRVNGGKSQSGDPNSSSLLEPAPSSAHSKNNQQTSAPASPRSMQFEPTPSRQKQSGLHIDTSGKTVFTTEKDKSPRISTSTSITSNYHTAQSTPVPSSDENLAWGSTAMAPLQGSADAAGDGLDENTPSPEERQQAQKIFDNNDEELAAGKYTAAWLGTPDRSMLRKAYMDLFDWSDMNILSSLRSLCTKIALKGEAQQVDRVLDAFSCRWCECNPNHGFKATDEVVCMPEANDNNTADVVHTISYSLLLLNTDLHLADIDQKMTKPQFIKNTMPTIQRVVIEAAPEAFSTAQPSKPQPKQAAEPERAGHTKTSPVPPLEKPPIHSPTAAEKSDEPPTIDIPIIEHPNVPPPRLSSRASFLDTGHGMQSLAGPLVSTPFNGTMKAWEAQIETVLKDYYISIHKQKLPLRGVTTGSDEHISAPGGFLTLTHNMLRRTPSTISRTGAAETYRGRGAENRLNAARWSSKARSRPRLYPPSAMGSSRTSLDDQSFVWSPSGSSTWSKNSLGKTLTSMSVDSLGSEYPRGDYQQSIGFANALSHAIIREDSTHSIAASEDPARVAMVLEDESLELAGAPWAKEGSLKHKHHLDSIDKRAKDRNWNETFAVIQRGWMRLFSFNSNNKSSLKPKQRQNGGIVVGGGNWMENADETWKFLLRHTIASALPAPGYSKSRPHVWALSLPTGAVHLFQVGTADIVKEFVSTANYWSARLSKGPLFGAVSNIEYGWSDAVINNAVSSIDDSNLPSSAPSSSGSAHLPRPSLQSSIRSSIDQQSVRPRLPADRIMLSDWRPPQQSMMASTSSEAEQLETLRSYVKHVEQELQRHNELRPALMLAFTPKHANYSKALHNWERKSSYLLREIVKFRTYIDSLVWAETMRQRIYHQADAVKEKELNAGSNQDPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4D816</accession>
    <name>D4D816_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_03251</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022594.1">
        <property type="nucleotide sequence ID" value="XM_003022548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581249"/>
    <dbReference type="KEGG" id="tve:TRV_03251"/>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1516"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2231" mass="255307" checksum="26D2258580259E92" modified="2010-05-18" version="1">MARRPGKYGNNYRSQSSSFIPKKSKTIGVSSLRSSEATSQDEKFQALRIADGIDETMGFARYEAGKKRIGWLCNMHSTTIEDPKVPGGRAAVEFYFLEENGGSFKAAVEYDPYFLIATKRGHEAEVEEWCKRTFEELLKGVKVVEKEDLKMPNHLLGYKRKFLQLSFANVSDLLAVRKTVFPIAVKNRKNVNAMDTYAELASANAGFDLFDDESNNRGQNSLQDAADYIVDIREYDVPYHVRVSIDKDIRIGKWYTVQSIHGLITLTCLEERLQRADPVVLAYDIETTKLPLKFPDAAIDQVMMISYMIDGRGYLITNREIVSEDINDFEYTPKPEYPGPFTIFNEPDEKAVLERFFSHIKEAKPSVMVTYNGDFFDWPFVEARASVQGIDMYAEIGFRKNSEDIYQSDYCAHMDAFSWVNRDSYLPQGSRGLKAVTVAKLGYDPDELDPELMTRYASERPQTLAEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDEVLRKGTGTLCEMLLMVQAYQHNIILPNKHTDPNESFYEGHLLDSETYVGGHVESIEAGVFRSDIPVNFTVETGAIDELLRDLDAALEFSITVEEKKSMEDVVNYSEVKAQITERLLNLKNCPNRNERPSIYHLDVASMYPNIMTTNRLQPDSMIKESDCAACDFNRPGKTCDRRLPWSWRGEFLPAKRDEYNMIRRAVENEKFPGKTKNHPPRSFESLDESEQATIVKKRLQEYSKKIYHKIRETRTIEREAIICQRENPFYVDTVRNFRDRRYDFKGKQKVWKGKVESLKSSGAANSEIEEAKKMVVLFDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGAHIIQMARELVERIGRPLELDTDGIWCMLPGTFPENFVFKLVNGKKLAISYPCVMLNHLVHGRFTNHQYQTLSDPSTFKYTTHSDNSIFFEVDGPYRAMILPTSKEEDKNLKKRYAVFNHDGSLAELKGFEVKRRGELKLIKVFQTQIFKFFLEGSTLEETYGAVAEVANRWLDVLDMHGSTLADEELIDMICENRSMSKTIEEYGGQKSTSITTAKRLAEFLGEQMIKDKGLNCKYIISAAPRNSPITERAVPVAIFSAEENIKRFFLRKWLKEDPGDMDPRTIIDWDYYLERLGSVIQKLITIPAALQKISNPVPRVAHPDWLQRRINTKEDRFKQKKMTDLFTKNPLANISTNIMDHRIPSTGDIEDMMQRRSQKPGTQLGNKLIQKRKAPGDNTTSQDPFASLPPVMPSIDKNYEDWLRYQKQKWKIQKQARLRRRKLFGAKKTAASDSTGSFFRNQAELTYVNTWQILQLRETSSPGEVRAFVLIDRKVHTITIKIPRQIFINFKDVDLPDVDITGCSVQKVNHTLPNGHPSVHLFQLSMPEETYLREASKISLLLNHPSVEGVYEKKVPFNIRAVLKLGNHCTFDEEQRGVLGKGLERGFDLSTLLPAPEPGVYLEGAEFQYVLLYHIVSGEREIFSIFSTKSREAHIVTYTKQRDIQGFPNVDKIFTEALQRKVDEQNSETWQQVFQYQDKLHFKTTQVTTKRKAHLEVGDIIKKFRNENTMPLMVVVQSPKSRQLPRLIPSLKDYPMVSLRSNASDNELPPLGWQPYAARQIVVHYLALDSWINHLLGFARYGNVPIGNLEKDDPKHLIDILYARQLEQNNAVLWWSASPLPDHGGYEKDNILGPLNSVEMTSVNIAGAYSTVCIELEVRNLAINTVLTSSLISDLENNEPALLNPTAPGGQQTISDGSGVLYSDTAFSAAGILVLRDMVKSWWNEACKGNGMADVMVQHLIRWVDSADCCLYDHALHQYMQMILKKALQQLIMAFKRVGSNVIYANPNRLILQTTKAEVGNAYAYSKYILQSIKEKPLFHFLDIDIKEYWDYLIWYDQFNYGGKACQEVVEADKQELEAIMNWQICRFLPTPLQSVFVDWIVEYVELMHGLKKPATVSGGADGTPRQTQLPFRPEDESESVEITSVLSQSFSKALKKQVAGLIRRQRDEMLHPELASDYDFPVLPGAMSPKHERNPTLVLVKYLMQVLGLSKYTALEVRLLRRDLLALFDIREFSDEGKFESPSSSLVLSQIICHNCTMARDLDLCRDPELLPESGTENKVSTTLPPWTCPYCSTEYDRLFLEERIIGEVQGLVMEWQAQDLKCAKCAGIMINPFMEHCSCSGEWVETIDRRATEKRLRVYKSIADFYGFKMLSMVTKGVLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D829</accession>
    <name>D4D829_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022607.1">
        <property type="nucleotide sequence ID" value="XM_003022561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D829"/>
    <dbReference type="GeneID" id="9581266"/>
    <dbReference type="KEGG" id="tve:TRV_03264"/>
    <dbReference type="HOGENOM" id="CLU_1147891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="242" mass="27599" checksum="38183F809C3B5454" modified="2010-05-18" version="1">MRRRSPFEPQRPNGREARDDNGGSTERRKRRRKEETKKGRRKHEERRGTGDKGVFVRATLTHVIFRLLGSLTAIVPEILTYIDIDINIKNPNPHSCTACHFGSVLCLDLVACHRHLDQLQLLPQRGRRRETPGEEEEQEGTARVSPILPQPTWSATVSHNADEAMECPLFLVGGHVWGCRWKEEEVDSHNTTTTTKYRPNLLEPVHLREVRGKLPKGQKRETLVWEGRSVCFYVASPLGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K1</accession>
    <name>D4D8K1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000179">
        <property type="protein sequence ID" value="EFE41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022435.1">
        <property type="nucleotide sequence ID" value="XM_003022389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K1"/>
    <dbReference type="ESTHER" id="trivh-d4d8k1">
        <property type="family name" value="Bacterial_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="9580982"/>
    <dbReference type="KEGG" id="tve:TRV_03438"/>
    <dbReference type="HOGENOM" id="CLU_038297_1_0_1"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055670" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="68"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="408" mass="45666" checksum="CE43FCE59FEE3128" modified="2010-05-18" version="1">MVVLPLFFAFFFLVQGNCQPRDEIPYVRKYFYVGGQYADDGNGDHIFRDQMYVEHLVPTKGPIKQQPIVLLHGQAQTGTNWLNKPDGGRGWASYFIEHGYECYIVDQTSRGRSPWIPENGTIATIPAEAIQRLFTATARYKLWPEAELHTQWPGSGVIGDPIFDAYYASTVQFLKSQIQQETTIQAAGAALLDRIGRPVILVTHSQAGAHGWLVADARPELVHSIIALEPAGPPFENVIYKGPYSRVWGLTNAPLTYSPAVIDPETEIVKQTIDDWPGSHCIIQADSPPPRQLPNLRRIRTLVVTAEASFHRTTDWCVVRYMEQAGISVDHVQLGDIGIRGNGHMLFLERNSDEIAAVLRRWMEEKDTKPAKKAQEAQEAQEAQEAQEAQEALEAPEALEAQGEEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S9</accession>
    <name>D4D8S9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022306.1">
        <property type="nucleotide sequence ID" value="XM_003022260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S9"/>
    <dbReference type="MEROPS" id="C02.008"/>
    <dbReference type="GeneID" id="9580853"/>
    <dbReference type="KEGG" id="tve:TRV_03517"/>
    <dbReference type="HOGENOM" id="CLU_006770_1_0_1"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="133"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="862" mass="95451" checksum="073A97377683E7BF" modified="2010-05-18" version="1">MSQLRDIKAQALEAEKDVRSASTQKEELQAAINAAEHYMNALRLVNDPVEKRLFDSKCKEYLTLAENIKQSKDGGQRNIPVIPVLQPAALVDREPTSTRTQSNREQIILLENSKLNGFVFPPWSMTAISDLREFQVDDEGELFLDVSDLQICPVQREIFDGWKRPAEILGHHTSGSPILLGPNPMDLVQDVTTDCSVVASLCTGASPWKEGVSQLVRSIQMYPSEDGKVPCISPSGKYIFRLYFNGCYRKVIIDDMLPSSKTLRSLHVIDRNNPTAIWPALVEKAYLKVRGGYDFPGSNSGTDLWVLTGWIPEQVFLHDDELAPGHLWQRITNFFQSGDILLTLGTGKLTEYEENELGLISLHDYAVLSLQERDGIRQMLIKNPWAAGPVWKGVGQLSENYVFSDGSEHETSHPSTTAPGTFWMAFEDVLQNFDNLYLNWNPSLFRYRQDIHFRWDLSSASIVPGCFAGNPQFAVSTKSGGTVWLLLGKHFKTGDYKKNTNQLLEVAPDADQTGFISLYVFEKKGTRVYLADGALRRGPYVDSPNTVMRLEMPPNSTYTTVVSEQSHQRSLYSFSISAFSMSPISINPAKETYSHVKKLSGAWTTSTAGGNAESERYPENPQFQIQILEKCDVNILLEAEDPGLAVHVSLIWSNGDRVACVRSRDIVVGSGDYRRGVALAEKKDVTKGMYTIVCSTFTPDQLGNFTLCVSSTSPCYVRQLPAEGAGHLVMNSGIGVFPPGTDRILAPISIPRLARLKLICRRRGSSIGDRNAAPSPILMTVELGQGPYKEILAGSGDGNFSDDVRGARIESVDLQPEFERRGGIWLVVERIGGPGGQVEDRIEVEILSEERIGIGSWGIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Z8</accession>
    <name>D4D8Z8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022264.1">
        <property type="nucleotide sequence ID" value="XM_003022218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Z8"/>
    <dbReference type="GeneID" id="9576870"/>
    <dbReference type="KEGG" id="tve:TRV_03586"/>
    <dbReference type="HOGENOM" id="CLU_2198902_0_0_1"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="108" mass="12120" checksum="750D062CE43C39E2" modified="2010-05-18" version="1">MEQVDEKPSNCVNSPTPANTETQRLLTNPLSTTIDKDSKGNEHMRMNFHVRHHLPRGPFDRILTPNKPSQVSGPLNDGVVLVHLVKLAGQSDFEYHLLALDVKGKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D972</accession>
    <name>D4D972_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000187">
        <property type="protein sequence ID" value="EFE41593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022211.1">
        <property type="nucleotide sequence ID" value="XM_003022165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D972"/>
    <dbReference type="GeneID" id="9579096"/>
    <dbReference type="KEGG" id="tve:TRV_03662"/>
    <dbReference type="HOGENOM" id="CLU_1421102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="195" mass="21823" checksum="1EA29EA1EC87C0BE" modified="2010-05-18" version="1">MLELEREMERENEMREREREMADRYHREQQHQQQQAQAQQQQQQQQQQQQQQQPHPVQSHTGSIPIHQPVASKVPSSIHGPNGLLSNLATATNAPQPSIQASNPPSSLFGSSMQHSEGPPRQYLQPSQPVLAFNSGPSQVPGSVAALAQGQQPILNVSFPPPTFHPIFFSYKRSKLCLCEWSTHNENDVLPSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAC1</accession>
    <name>D4DAC1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000206">
        <property type="protein sequence ID" value="EFE41202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021820.1">
        <property type="nucleotide sequence ID" value="XM_003021774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAC1"/>
    <dbReference type="GeneID" id="9578698"/>
    <dbReference type="KEGG" id="tve:TRV_04068"/>
    <dbReference type="HOGENOM" id="CLU_1571751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="170" mass="18892" checksum="559C5DEC31EEA78E" modified="2010-05-18" version="1">MAHGSTPMAHDVPAVLRAEDVGSIYLLTPYFLAVSISLYQGGKKKKEKEKKKRKASPMLLRLFRDAVEMMMSWSSSSSSASVLRGKRGGRSWTGERRCFAPIRRRQDIASAMCIDDYDYDADNNDGDGDGDDELGGAGRYPYYHSLHACTLTPAIEDAAIACCWRKTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAE6</accession>
    <name>D4DAE6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation-specific protein Con-10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021762.1">
        <property type="nucleotide sequence ID" value="XM_003021716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAE6"/>
    <dbReference type="GeneID" id="9578642"/>
    <dbReference type="KEGG" id="tve:TRV_04093"/>
    <dbReference type="HOGENOM" id="CLU_122062_1_1_1"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="93" mass="9817" checksum="652A4B4AB500DD46" modified="2010-05-18" version="1">MADYNPANFANRPQEEVEEIARKGGQSSHSSGFASMDPDKQRDISSKGGKASGGSFEPGSERAREAGRKGGKVAGGGSRMVDEDEEDLLQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAT9</accession>
    <name>D4DAT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021657.1">
        <property type="nucleotide sequence ID" value="XM_003021611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAT9"/>
    <dbReference type="GeneID" id="9578618"/>
    <dbReference type="KEGG" id="tve:TRV_04237"/>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="48207" checksum="3720AD8D533ABE91" modified="2010-05-18" version="1">MAANSKSVSEVVSWIKSQKPVVPQMKDAPTFYRNLEEALDVRRSTQSMLTRGQNTWKTGDAIDFCSNDLLSPGLTGELRAEFLAELARHPDFALHSGGSRVMGGNYDYIEAVEQEIADFLGSETALMFNSGSNGNIAIYTAIPRPGDAIVYDELVHFSTHTGMAASLATTKVAFRHNDLDAFREAMSSTMDSHPMLKDGSRSILVSVESIYSMDGDVCPLVEMLEIAREICPKGNFAFIADEAHATGVVAVVLGNTTVRNTMLNFAGSLVNTTAPSFPSVAVVRAAYNLMRTGATQKAQDNIQHLVKYFFKTIISNPIWDKATDTGILSIPVSEDYESNDFVTHIVPIWTRQKYNWWLFFHLQLAKIAVVPIDYPQVPKGKSRVRVMIHARNTEAEVDYLAATICSFVSEMIEIEEGGEKGKLPKAAQQIYALMAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV1</accession>
    <name>D4DAV1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021669.1">
        <property type="nucleotide sequence ID" value="XM_003021623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV1"/>
    <dbReference type="GeneID" id="9576752"/>
    <dbReference type="KEGG" id="tve:TRV_04249"/>
    <dbReference type="HOGENOM" id="CLU_003318_1_0_1"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="725"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126636" checksum="D59299957C1172F6" modified="2010-05-18" version="1">MRGKTPRTARKILKTPREARVPLSDIFSSGHNARHSSGPTNRFTNEIAKLLTSNEKLRSPLPSTQNSNPNYNTDSGYHGMPDSLPTDTNEPDHQMEVETATQVIEDSTILPVDEGPKSPANVRRITEDSFHSAREVAPSKENTVEPMEFEYSRYIPKNTALPKQHPLSTSPRQEKQNESQNRPQPLASPHQPEAKEDLDDPNFDDIGSPSDGPTPVRAPIRKSSLTFASLPAREPLTTKRSMGGRMSRTSHIDPPKMNMSIVGQPGYLGRQTGGNRLTQMLLDNEKNNKPLESNDKAGTDDSADNDHDSDAENKAPKRLNKSSTQLLHEKINMLGKTQAPRTTKSIAPAPSLGTQQLSYPDLPPPTAASSNDNTQNASISRPSSAMEAAHGSPQRLPPTPNHFTFPADKFQPEAQIYRDTPSPASRAPSAHPVSPERRSPGPKPFRPGGFFHSKSSSVPSFPISPRPGTAGSAQKAPSVADTPGESTTPAGSPKRFDGPLSASKSKLQSLMKSARGLFGSSASVSATAKLETLSPTWQRTQASTQNQPQATATDPPSPAKAPRTRGSIEREHRRKEQELKDRKQMEEQERVREREKLHPEPTKPANIPSKPQILDKVEVPQHSSENLPARRVEPVPKAEPARRELEPSTEEGRGANTHAASQSHPLPNEGRRPAKAIREMRKPKPQPVNIRVGTLSSQRIRAESATPAPPSAREPTVQQTSVSKKASNASLLTTASSSGSLKSSASSASSKSKALLAVERKKEQVNASNTILFFISSDTYLSEQEQREAQRKLDQRREVDRKRLAQQEEASRQLQQDKIRHEREQSVTDDPKTLAKKQAIEKRRLENAKRLEQQRGRQQTPSNDTPPSRPHNYPPPNPAKPPKRAHEEQNTVRPPATKAGSVHQLDGKRRKTEEEIVAPEPTAVRPAMAPPIRQSNASKLNNFPSVSKYAAAPPVNSMQGCPPIFKNPAGAQKPFQTLPHQTQGNRPAHPLEMAKYANGRIPFAEPNNVPPQPTSAHLKTPGQNKHVIPKSSPAYPNGENIKLPDIPTDSEDEDSDAEPCHVPDWAKEENLHNILVQQESQDGEMVFGPSAPLRMEEIFKGNKERLRKFRDRTSSANWNGPDGLTQDEIKWDMAEREKLKNNGGWVFSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV6</accession>
    <name>D4DAV6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021624.1">
        <property type="nucleotide sequence ID" value="XM_003021578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV6"/>
    <dbReference type="GeneID" id="9578585"/>
    <dbReference type="KEGG" id="tve:TRV_04254"/>
    <dbReference type="HOGENOM" id="CLU_051536_0_0_1"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055397" evidence="3">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="40158" checksum="F2F31B3D0A476458" modified="2010-05-18" version="1">MLLSILVLSTLLLQEVSAVRFTPFSPCADVCGGMIANTTHKEIKCHDDEFESTAEGRRFRDCVSCELQSTFYDVPHDESDVKWGLYNLRFAFSTCIYGIPAVKQSLSTPCQVTCQGLSESIIYKLTEPIGRNLYDFCGISTFSDKDITDCTICYSLTENEKFLANFLEAFREGCRARVPAGDKFFIEPNRIFNKLALPADQDPQLPGKNTGRSRKNLILIIVLPIIGFLLFGAALSVGCFFFIRNRRRRSRRESQSSSLHERWNDTSIMTPSHNGLHKYWGGEQTPQPQHPYDPSMAQSYNHSYYGPDQQDVKYPSEAHMMTSLAPQTTQHATDGDRKVPILSAAPPPRKSLTNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB51</accession>
    <name>D4DB51_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021503.1">
        <property type="nucleotide sequence ID" value="XM_003021457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB51"/>
    <dbReference type="GeneID" id="9578451"/>
    <dbReference type="KEGG" id="tve:TRV_04350"/>
    <dbReference type="HOGENOM" id="CLU_433601_0_0_1"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="345"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="631" mass="71511" checksum="F6705ACA4518994A" modified="2010-05-18" version="1">MDAFPPSYVDHNLPLVLISGLAAAGEAGEEAGEAIVSGVDGADGGVCVFSDFPPVSGAVADGLLAALLAEDASFWPWSSRYFSHRANGVGLRIQRASRTYTLPRKKADTTQYAPDSDGLAPVPHSPLSPLTPGSEVFPDGMVTPSWISKHQCLVPAAFVNFFPLTTDTNMSTLKDNQLKIEINSLKRDWAQSGYKTRFVVVFLFEDGPVLEDANYRISSIRKATGLDPRNVFTLPPGPSPLDIQRFVKSLLFSIQGAAVEYYRDLSKHSRRKRNRATIPPPTAPPTSGTSQTLSQQGWNVRYEFKLGVLAEFRQEMDAAGRSYETAYDLLFGDEVFGAIAAWSPRFDEARMLADVLALRILRCHLWLEQTTPAVQFWAAHRRRIQSIAHNKGKGTNNYGWEAWEVNWSLIMAHTISRSYIPPSPVGTNSGPIFVLSEKTMLSGERVSPWDFLHHRGYWLARAAKHTARRRLHAENIPQEDRLPPDQHNATSQRKALSNVYDTYQAPEPHVEYPIDDRPGDKYSHQILEFLTESVAEFAKRGQVRMVEKQKFTMAKEYVRLEAWSDALDILRPLWLQISWRREGWWHLMEECAWLLRDCAVRCGDFETIYRIDWELMNKKPERLMKRHLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA4</accession>
    <name>D4DBA4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CP2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021556.1">
        <property type="nucleotide sequence ID" value="XM_003021510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA4"/>
    <dbReference type="GeneID" id="9578517"/>
    <dbReference type="KEGG" id="tve:TRV_04403"/>
    <dbReference type="HOGENOM" id="CLU_012196_1_0_1"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Grh/CP2 DB" evidence="2">
        <location>
            <begin position="247"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="707" mass="78704" checksum="8C63C5DE61549244" modified="2010-05-18" version="1">MGTAGGLSHYIYAWGMAFESISNFFVDLDQKPDEALYTHFRQKYPNASANFKAGDSKNSKAFIPSPSLKQLPCQRPDGSNLYNPALKVQLDQLAVTQPLVYPDDVPFSTFTNISPSCNPCKTPEEVLTDKNRSIDLLTQPVTFDAVDSNTIPCTSSMDQSLSHSAVDSAAALPQMPVSFETGISACEIEQRNINAPATLLHGMPDLSTLSNVPNVTDGLHLGRDAAGVTANGHRESAGSPRNSDFGDDFRFHSTLHAATAMVQGPDDIPITYLNKGQIYTLTVSDAGVSDFGHYPTKYRTTVRITFDDEKQRLKPASYWKLWQEGRGANRAYQSESTLLAVEYVPHSQGEDLQPRYRQVQLEHNSLDGFSVIWTPHQINNRRDCAIYVRFNFVSTSFSYSKGVKGVPLRLCAKTEAISSSHEMPGASDYSEISYCKVKLFRDHGAERKLSNDLIHVKKLIQQVKEQISEATLGPSNGGKRKRCNGSALITGNESTTKTRKCSKIPWSYGQDLAMKGPFEDDLRMELKRLTDKTMSRREVSILNLRGEPQDDMDLFPLEMDTRRTSADALGPDAETESKASMKDPSKYIPYLNVSLLLASILTFSLEYCFYVQRRQNNKGNEGYFHAIYIQQLTAKAFTDALVKKWKFKTTGKVHTLLIHEDGLSVVADDLAVQALPEGKGVLFDFLEVHEEPLDVNMDFDSDTAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG8</accession>
    <name>D4DBG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paf1 complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021394.1">
        <property type="nucleotide sequence ID" value="XM_003021348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG8"/>
    <dbReference type="GeneID" id="9578273"/>
    <dbReference type="KEGG" id="tve:TRV_04468"/>
    <dbReference type="HOGENOM" id="CLU_021991_1_1_1"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54751" checksum="899E24FAFE0F0C77" modified="2010-05-18" version="1">MSKSKDSGPSGSYHQEYIASLRYRNDLPPPEMPPKFLDIPHEGLDRFLTAGFASNMVRREEPNIDVDAEGGMPIDLIGIPGLHLGDESAIMAPENPPPIDPADLPLLMTLDQLRNPAPKNVNVSFLRRTQYIASSGMARGIDSKGSVFIGGPRKGAKPKPTRDDPTYVKKYIQKGFDIAYPKSKHTGPDTVSQIQGLAPTKAELDAWANPVHPDNPKLKPVGFYPVIPDVDGFPDSGGFLQFKFDKTPVPPVNGRRDDRMDMSILIPSSPEPRVLQQHTSKTQLHKANPALYPDPGPIPYDYDLYLPQKQSSTKQIRRSLNMTNPDRDSPSNYAHESSSGDKYHHYDRLRTYATNTQVLNTEHKYKDVSIVLFDPAEIPEGEREMFRLNQKAAYYYPIISKTRIKPERSQKIARAGLAPTRATAKEDQVDQIQVKLRDPIPEESHKRAGHRAQIDSKYTNPFSVEELEKGQNETDAPGDEEMADHDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBI6</accession>
    <name>D4DBI6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021412.1">
        <property type="nucleotide sequence ID" value="XM_003021366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBI6"/>
    <dbReference type="GeneID" id="9578291"/>
    <dbReference type="KEGG" id="tve:TRV_04486"/>
    <dbReference type="HOGENOM" id="CLU_3410807_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="29" mass="3607" checksum="FE4AD9F434B8A3A5" modified="2010-05-18" version="1">MKKKKKKKTKTTMKMKKKTKKRQRERRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBP0</accession>
    <name>D4DBP0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021334.1">
        <property type="nucleotide sequence ID" value="XM_003021288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBP0"/>
    <dbReference type="GeneID" id="9578225"/>
    <dbReference type="KEGG" id="tve:TRV_04540"/>
    <dbReference type="HOGENOM" id="CLU_1074388_0_0_1"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31168" checksum="E3AF3C84E3D095BD" modified="2010-05-18" version="1">MQSLAIKRSREEEKGDEASEDDELTLRRKPTQTQGTAALPLTPATTEDQWNDSDAAEIWDGQQTHTHTFPSSGSHIHLEADTDMNMMDCASTESSTLPVWPPTGHGNGDRRRNISSSLNFTDTSLVVTQACHKSSSVNAPVVSSSTSDLHPPASAITHLEASRFPSPISEFQAETKKYTGKFTLHPFQPCSHLDDPSMPSNTSLSNSVSSKSTNKFGGPQGNSPTLHPPTNPEAGSFQKRPDLTVNHTATLMAKQPKKPTIAMGFRADCDKCQRREPGHYSHIVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBU1</accession>
    <name>D4DBU1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021279.1">
        <property type="nucleotide sequence ID" value="XM_003021233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBU1"/>
    <dbReference type="GeneID" id="9578124"/>
    <dbReference type="KEGG" id="tve:TRV_04592"/>
    <dbReference type="HOGENOM" id="CLU_072377_2_0_1"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="197" mass="21725" checksum="8E9732747B12A8D8" modified="2010-05-18" version="1">MPHHHHHGDDHDCHGEAGHDHSNDITPALQSLLYKQVDFDKIVTMNESEPKAGAAIVKKTWDQRLDEEPQLESDADEQLLMHVPNRPDMDFSTASDLAPTQTISVPQSLTGSQADVIEMPLNRALWNGTTSITLFFEDNWSHGEEDVTKVGYVGFKGDFLALNKEPITFLYEAAANPKDHTVIQGVDGVGKTIGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC00</accession>
    <name>D4DC00_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine Rich Repeat domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021220.1">
        <property type="nucleotide sequence ID" value="XM_003021174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC00"/>
    <dbReference type="GeneID" id="9578065"/>
    <dbReference type="KEGG" id="tve:TRV_04652"/>
    <dbReference type="HOGENOM" id="CLU_305475_0_0_1"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="108461" checksum="C4A93FB79855BA19" modified="2010-05-18" version="1">MGVTVRGRPQACQVTPKSSLHYATLAVFLLLLLLRDDTSSSSTATPGILVFFFFFFFLFFHFVFLLIIFCLAFYLLYHPLASTSSSASASSLSLPPYTSAYTSPIDSSRKTRSRQPKRTTTNQQKREKEKEREREREKRASVSQIYWESLQLSSVSVSISAYLVCCVACCWTLRSYLYLPVASSYPVIITLLSVVRLILQSKEKDQSIKKKVDSKRKTKRQETKPSSCSAFSSLFSALVLPFFLRPNSTTQAKKPQSTPTTATPAQATCQRKERNQTENQEKQEEAKTITIQYTLPYHSMTPSDLAHQPSPHPPALPVSALDQDNDIDIPDADDVEDIKIAAAHKRQDSFSSQARSHSRSSSIGGASFGSIEEDNTGIAQSFVDTKESNSSGDKTHAADCSASKAKELKAPIPDFCCPCGTFRGWKQIRLGGRKLSRSYSDLRLLGGTQARGWAWEEEAPNPEPPKAQQQQQQNEDQEEVLELRRPAPRVTKRACLERLPVEILDEIISHLALDIPPNGYTPRNVDLISCLLTCRTLHSATLGVLYRHITIPHSIIFSKALNHIRQYPSLGTIVRRLDFSHFTSVGLGRTQQMNVEIQNLTAKTLLQCLDLLPNLKELLLQEHVEDDVDGDVVRKIFITKTLLRAIDFCGCSSAKFSSGFLSAVTQEPEFPSVLPNLRRISLHECTGLPDEAFQSLLPRLINLTHLDVAHTQISNSTLFLIPYTARLTHLNISRCTKLTGPEVVRFLSTHPAVTSSLVYLNLMVDASRHRILEEADVPNLLPHLKSTLRSLNLGGARITSAHMPDLLRLSKHVEELGLSSADLTLDDINSFFAPPPSSATGSSNATPWQPSHLRYLDLTRNPYLNQAALFNSKSCLLVTPQSYPLLVIEMSERIIAPLRSRSKSNNNRSGWVVRELGRRGWYVREPSGDPSMPVDDGQRSWKMGAHWWGTRKIPVSVGDVGGIYGHYMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCA9</accession>
    <name>D4DCA9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021147.1">
        <property type="nucleotide sequence ID" value="XM_003021101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCA9"/>
    <dbReference type="GeneID" id="9577990"/>
    <dbReference type="KEGG" id="tve:TRV_04762"/>
    <dbReference type="HOGENOM" id="CLU_017006_2_0_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06197">
        <property type="entry name" value="FNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="381"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="650" mass="71078" checksum="E87B7DDA1E7EF7BC" modified="2010-05-18" version="1">MAFVLAGEVQWHEGEKKMHELMHVPYEENPTAAFLSPGAAALVQKCPLLAVGTLDKQGRPWSTVWGGQAGFVGPVAQSIIGIRNVIDGTHDPVAETLLGGELAGTIVKEPPPGRLMSALPIDMENRRRVKLMGRMVAGSMEEESQEGPGNSSINDTTLGKSAQVQLVMKVEGSLGEITISSLAPYIPCPKSTDLRLGNCPKYINKKRITQALPHPKLISNSPHLPQEALDLLGRIDTLFVASSHGNDSMDSNIRGGPPGFVRVLSNDSTGAVIVYPEYSGNRLYQTLGNLQTTPLAGYAFPDFELGHILYITGKTEVLVGKDAAKILPRSNLAVRVSVTAARYVENGLSFRGEAMQRSPYNPEVRYLASEKPAPGSQLPDNEEMRVILVKKDVITPTINRFKFKASDPSAVLKWIPGQYATVSFRDELDMGYSHMRDDDPTSINDDYIRTFTVSSHPGRNLAKNEFEITVRRKGSATSHLFRASERSGLELSLRGFDGSFRFECSGSNRSVDHESCPLPFIAGGIGITPLLAQLPDIDMSRLKLLWSVSMKDVGLVHDVFEQYSNLPNATTVFLTSGSPAIENDMNEDDKKTLISVTSSGAKIERRRLIKEDLSAVPDAGVWYICAGTELKTAATNWLTGKKLIYEDFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE6</accession>
    <name>D4DCE6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04799</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021086.1">
        <property type="nucleotide sequence ID" value="XM_003021040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE6"/>
    <dbReference type="GeneID" id="9576738"/>
    <dbReference type="KEGG" id="tve:TRV_04799"/>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="357" mass="40045" checksum="D810FCC969CFDA9B" modified="2010-05-18" version="1">MAYVKDAPGLRRQLESLPAAEREAAVKPFLMPPRVRKSSVRGRKASSKPVRRFLRSKLYYLLYFLIHIVFSIYSRIRQSYHAVVDRVLAILYYHHRTPELIRKDVRGLDRLPEHLSVVLTLRREEDALETLMDEVAELTAWSSCAGIPALSIYEKTGILKSHIPALHRIITSKLDTYYGPPSHQPSLGVFAPHHPLYAPKLVPQASKSNIENITVLLLSSTDGRETLVDLTKTLAEMAQHGKVSPQDIGIKLIDAELAEMMTIPASSPQDPGSETNGTDSPSGSLPTPLIKAEPDLILIFGPYVKLDGYPPWQIRLSEIFCTGDHTTGIAGEVEAVEYQRFIKGLWKYARAEMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL7</accession>
    <name>D4DCL7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021007.1">
        <property type="nucleotide sequence ID" value="XM_003020961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL7"/>
    <dbReference type="GeneID" id="9577859"/>
    <dbReference type="KEGG" id="tve:TRV_04872"/>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="684" mass="76238" checksum="F3156448AF567819" modified="2010-05-18" version="1">MYPHGAPMPPPQKPETFMLSNEAQQSLPQDVQVALQQVDNLKYFLISAPVDWTPDQLIRRFLLPTGDYVSCVLWNNLFHISGTDIVRCLSFRFQAFGRPVKNTKKFEEGIFSDLRNLKAGTDASLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTVAVNEPALSFEFDSSQSLYEQLTKAQQANSSSFSAAHGSSAFASSHSASPMPRATDSMPPPQMAPPAIPVVHDEQQNTMYHGSVSSDPMGGQIVKTEADYPQFQYDRNGVPVSKVHQRHTSMPTYMEYSPAPSFVSSHYDEYANRGISFEPLTPPQHTMHLTSEPAYIANEDTGLYTAIPDIGSASSFNPMMQLPPSNVAAPHYSTASRSFPSSSVYSVIEGSPTYKQRRRRSSIPPSITNAITAATNNLHVQSHSQDMHQPQVPVQPHAVHRPSDLRRSMSTAIEGDASHEDSPPRAMYSQGSVHHSRTTTPLPSLEENTQVSVPISMGETTTVSSLSNMETIDGTDAMHLMNGHQGDRPGPIRRARSATMMELGPYPQKSHSCPIPSCGRLFKRLEHLKRHRRVHETQQSSNTGSQPPSFKEDEQENDREQSVAVSQHEQQPQQSQQVPTSSANYLPTTVVNMANVTSMHSMGTHSNLPSMVAPQIIQPQMVQPQMLQQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCP8</accession>
    <name>D4DCP8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_04903</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021038.1">
        <property type="nucleotide sequence ID" value="XM_003020992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCP8"/>
    <dbReference type="GeneID" id="9576685"/>
    <dbReference type="KEGG" id="tve:TRV_04903"/>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="44427" checksum="BC2C665DF5C5B7A0" modified="2010-05-18" version="1">MASADSVEAQEGVAMAEQPSTDLQVQEADATEVTETALTTTDGADKEKKTKIIRRKRRPARVQVDPSTVKSEPPPQTGTIFNIWYNKWSGGDREDKYLSQQPAESRCNIAKDSGYTRADKITGSFFCIFFARGLCPKGHECEYLHRLPGIHDLFNPNVDCFGRDKFSDYRDDMGGVGTFMRQNRTLYVGRIHVTDDIEEVVARHFAEWGQIDRIRVLNQRGVAFVTYTNEANSQFAKEAMSHQSLDNNEILNVRWATVDPNPAAQKREARRIEEQAAEAVRRALPAEFVAELEGRDPDAKKRKRLEAGFNLDGYEPPDEVWYARSRELEQAQDGARELEPAAQPGLIEAPPPAQPAAGNGILSGSTLAALQSYGGSGITTKPAETKSSGGPLVAYGSDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCS0</accession>
    <name>D4DCS0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000250">
        <property type="protein sequence ID" value="EFE40346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020964.1">
        <property type="nucleotide sequence ID" value="XM_003020918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCS0"/>
    <dbReference type="GeneID" id="9577816"/>
    <dbReference type="KEGG" id="tve:TRV_04925"/>
    <dbReference type="HOGENOM" id="CLU_084839_1_1_1"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="229" mass="24937" checksum="96173549537D12CF" modified="2010-05-18" version="1">MAMFSVVLPGRPCLTEAVPIQPDPNTPPTNFAFTFPAAPKFSHIVVFLLPGVTLPPDVAAAVYIQFPNQPGNGQPQQQQPEFRFLGAIANEKPSAIFKVNLPGSQKPMTEAEQENEMMDEGAAAVDPNAVITLGIAIESTQVIREKLATLQQPSTGMELVKRTGQTGMTTKVLAQRIIGNAFNFLASFAASDPRAQGEEVVPLKSFRDWWAKFERRIEADPGFLEREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCX9</accession>
    <name>D4DCX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020909.1">
        <property type="nucleotide sequence ID" value="XM_003020863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCX9"/>
    <dbReference type="GeneID" id="9577730"/>
    <dbReference type="KEGG" id="tve:TRV_04985"/>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE40291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="397" mass="43432" checksum="DBFF1C828DEA0D21" modified="2010-05-18" version="1">MAGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVASEIFSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEEAENPLGGYGRTISHLIIGLKSYRGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDIMSMMGQLMKQKKTEITDKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESSISPIVILASNRGNTVIRGTDDIVAAHGIPSDLLARLLIIPTHPYNSEEVKIIIRLRAKTEGLQITDAALSSLAEHGNKVSLRYALQLLTPASILARVNGRPNGIEESDIAECQDLFIDAKRSASIVANETGAFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCZ9</accession>
    <name>D4DCZ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020929.1">
        <property type="nucleotide sequence ID" value="XM_003020883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCZ9"/>
    <dbReference type="GeneID" id="9577762"/>
    <dbReference type="KEGG" id="tve:TRV_05005"/>
    <dbReference type="HOGENOM" id="CLU_011776_0_0_1"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="989" mass="113351" checksum="952381DAD63C9EA6" modified="2010-05-18" version="1">MNERRKVRLSLLPGSTPSVAQRRAAFEQKKDAGAGAGAGAERPQIRRTRSSRIRRRHEELQGIAEQPLQQEAQGGIQTQIQETEVEVEVELPASGSVDTVESDSRPVDAGADINIARQPQPQPPLQPPPLQQQQLQQQQLQQRRYSRWIAAAPRRPSTLRTVTVPSPEPPLLTPPLTSSSSDSLCFAAPVQAPAYHDSEPPCKPAAQERPQLILHTPPTSTRTSSSTASDPDMADENGSDGSLVVPRLEDLLRHPEDLEKISVLKAEYTRKKENVDSQLREGLRDQLELVQRSLADLAEGRRQIMDAKMGPQGIDRLWAESQSALGDFAQIDKLAKIQRNFEAVLFMKKGLETFHADVAEVERMLREDDMDMENQPNLLNIHMALSRLRDFRDEAIDQIRRAKDKSSEATLTELFEGLDPAIEWFDDHLGTACMNIIPLIQADNRSMVVRLAVVIANEEKNDAKVRALQDAQKDHEYLASRFKSMNIGPKTIRGYKENFLKSIELYAQPNFEDSKQQFLDDPDRLEKSFKWFFNDLFTVQQGMQNLVPKKWKIFKTYTDIYHRMMHDWLIEFVDDPQMPAANMLAIINWSEKYYKKMKKLGWEASDLVPNVLDDREGELVQDWRNLIVKALDEWMDRMFNTDKRAFLDRDMDSLDTNPDGFFRTKTLGDMWRMLHEQLQAAGASQRTDVAEGVVDAMFRSLKTRQSMWQTMLDEECAKYKTSTIDQPESLQQFQDWLIAVANDQIACIDDNDASGQLGHLTRFNRDFEPLVTDKYLTAQAANEVATIRDGYVDLGTHCISVFIDLIFSVDFRTTLPEFFTQKWYGEFAMKRMISTFEDYISDYHAVLHPSLRDILVEEISDELLVHYLSCVRNKGAKFRRQDPYTEKFKDDILTVFGFFQKFPDSFGGGIKDRWRLVDWLVRLLEADKAGVVVVYEGFKTEYWDLQLSWVEAVLRCRDDFERSMVSAIKAKAAELSVEMGPDTLMGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD70</accession>
    <name>D4DD70_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05077</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020851.1">
        <property type="nucleotide sequence ID" value="XM_003020805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577602"/>
    <dbReference type="KEGG" id="tve:TRV_05077"/>
    <dbReference type="HOGENOM" id="CLU_002125_2_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="247"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="471"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="662"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1287" mass="143341" checksum="70C623DC5A7E3CD7" modified="2010-05-18" version="1">MTTQKKPGGYWSEANPVPTIQQFIAELDAGKAERDRQIDEEARKKPTPQKQPTGAAVPHRKPVPKTKTKGRVVTDPTTGTEVEIDDVDENFKKAVRDPQVRFYPFLYPRMVKEKVLSVQTKPSQKLEEYKHTQDIVSPPEPIAAGTTSDVPIHGERTNILFHPTPSISYEPMFKILEKRAGVLCSVIFGSILIAGRFAGGELKWIFPLACCVATGVWLWTYDVIRRGRTFEWHSEKLRGQTATANLLPESAEWLNSFVEIFWGLINPDMFASVADTIEDVMHASLPGIIENVRIAEIDQGSNPLRIISLRSLPDGQCSDLIEGLRNYNLENKDEQQAAAEEEGGQPYNLECTFAYHAKPGENTFSRAQNMHMMVVFYLGVKGLFGVPFPIFVELSELVGTVRLRLQLSPEAPFAKSLTFSLMGMPHIRAGCTPMIKRGINILNLPLISNFVNYAIGAAVSMYVAPKSMSLDLGMMLGGDDIQKDTSALGVFWVRIHRAKGLSKQDKRGSKGGGSDPYINLSFSKYGKPMYCTRVICDDLNPEWEESAALLVTPELIKADEKLSVELWDSDRNTADDIVGKVELSMQNLLQHPGKMFPITSKLQGMDAGTEMPGELFWEVGYFRKPHFRHALRTDGKDETLPKDLKDHPALQDEKGNVPEPEDDAEAVTCTPPDPLWPSGICTIVIHQVVNLQVQDIKGTLKNRKGNEYEAARSYGESTGEEGKQFPTSYCTVHLNDEPIFRTRAKAVSSKPIFNAGTERFVRDWRSAMVTIAVRDQRNREHDPILGIVPLKLSDILQASSQVTRWYPLDGGIGFGRIRISLLFRSVELRLPPKLLGYDVGTFSITSNKIILQNCASRGKLKIRTSGVHYSVPRSAWKPDSIEENGGFFDLTSDLKEEIILPTKHRYRSAIIFEVQHSSGTAHALVWLQNLVDNEETPVDLPVWTAKNAWRLVQNYMTEENWEEAKNSPGLEDLEMVGRIQFSCRFTPGFHQTHEKLVNNNDSREAFETWEASVSEGVRGEIRSEVPPTVQRLHEKSLVQERDILRQASAKLRRPRSKDSNLSSIDDIIRQSMTGNASSRMEGGAASEGQHENQSRNQSRPTTAGSANANANVNTDADAGVTANRTVLAPMTVGGDGMPESHNNPQMMDYADGPTTTEAVDRPLGEGEVAGAEVAGGGAMASHEYDLDDGRVDGHGENDNNDDNTDTALADGVLSESSHETTEERRERIGNKENRRSEWRKHRGVMQWRPARNAAFVKHEASFAMKKVKDKLMGDMTGREPDIQTEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD77</accession>
    <name>D4DD77_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020808.1">
        <property type="nucleotide sequence ID" value="XM_003020762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD77"/>
    <dbReference type="GeneID" id="9577559"/>
    <dbReference type="KEGG" id="tve:TRV_05084"/>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="17675" checksum="88491E7FA3282A98" modified="2010-05-18" version="1">MADDEQHNVTFESPDAGASETFPMQCSALRKNGHVVIKGRPCKIVEMTTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMDVPNVRRQEYQLLDISDDGFLNLMKDDGTSKDDVKLPPGEVGEKIERLFKTEEKDVSVVVLTAMGEEVAMDAKEVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDL5</accession>
    <name>D4DDL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC bile acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05226</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020700.1">
        <property type="nucleotide sequence ID" value="XM_003020654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577399"/>
    <dbReference type="KEGG" id="tve:TRV_05226"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1178"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="402"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="607"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="936"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1268"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="864"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1559" mass="173099" checksum="911984B9AFD31C6E" modified="2010-05-18" version="1">MNKEKDLYQSLCQLYQDEDGHATELSSEAFSDRFQRSLIALASLTGVLASLAIAVLDTDGHGVYSRPIILQWLIFTVWVSGQPVFTIHCNYIYILEYQISILTYNLIQGMLLIQAAALSVEPFSTKRYELGLYKAVSCCFLLFVLSGQLWSIKSMDGWQYLSSPHGIVLLVQILAGLSSCCASVSLPRRPELYLDGKPVDHQFTGTFFGRISFSWAGPLLKFAIKNQTLEIDDLPALDYATRSMNLRDVFDKAKKPGEKLWRTLVRVYASSLISQALLVVCTSIFNFAPQYCLLKILRSLESRNSVSWHPLDAWVWVFALGGSILLSSTVESWLYWVAQYQLGIPVYEQLSAVIFAKAIRRKDVKGRQQVNGQSEQGDKQDHPQGPFEEDGEDDRKTRQATINHIAVDATRIADFAAYNCIIILIIVKLTITIIFLNGLIGWKALGAGLLVSMVITPMNIYTAKRYNSSQNTLMDHRDRKMGVVAEALQGIRQIKFSALESQWERKIFAVREAELSAQWQTFICEIFLVTIWIIGPVMLSAVSLGVYTILYGSLSPSIAFTTISVFTAMEFSLAVLPELIADFIEGFVSTERIGKYLESSERIPTIIPSEHISFEKSTVAWPTENIDYKAERFTLQDLNINFPSKGLSVISGKTGSGKSLLLAAILGEADVLEGVIRAPVPPPLEDRFDSKATKANWIIDSATAFVAQVPWIENATIKENILFGLPLDKERYEKVLFACALEKDFEMLPDGELTDIGANGINLSGGQKWRISFARALYSRAGILIMDDIFSALDAHTGRHLHIYALTGELSEGRTRILVTHHVGLCLPQADYAVHLENGAIKYAGTLVELRRTGTLSEILAAEDTKQEAKKSSPSPALHKQSAEGGSANAQTGVQGQTKEPPRKFQQEEGREIGAVKLINYVKYLQNGGGLPFWTVVMFLFTLFATLGVLRSWWVSIWTRSVEEMAEQKLDIMFHVTNRILTPKELPSDKLWFYLGIYVALSVLSCVVGSLRYAAFLYSCIQTSRNIFRKLTYTILRTPLRWLDTVPLGRILNRFTSDFNQIDSKLPFDLSGMVQNILQILGIIAAGVLVSPFLIIFAMILLLLCFHYSNLFLQGAREIKRLESNAKSPIFEQFGSALIGLGTIRAFSKGQAYIERMYAKIDRHAQAYWNLWLFNRWLGFRMSVIGAAFASATAAFIVSLSSIDASLAGFALSFSLQYTSAVTWMLRKYANVELEMNSVERVFEYSDLEIENQDGLDAPAAWPTEGRLEVSDLVVAYAPELPPVLKGLSFTVEKNQRVGIVGRTGAGKSSLTLALFRFLEAREGSIHIDGVDVSKIKLAHLRSRLAIIPQDPVLFSGTIRSNLDPFDEYSDSELQNALERVHLVPPADKMSSISSIEAPETPTESGVSTPTAVESSASSTLASRAGTNTNIFRNLNSSISEGGLNLSQGQRQLLCLARAIVSRPKIMVLDEATSAVDMETDALIQQSIRSEFGRNSTTLLVIAHRLSTIADFDRILVLDAGKAVEFGTPKDLMNIENGVFKSLVHNSGEREALESIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE47</accession>
    <name>D4DE47_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020517.1">
        <property type="nucleotide sequence ID" value="XM_003020471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE47"/>
    <dbReference type="GeneID" id="9584243"/>
    <dbReference type="KEGG" id="tve:TRV_05411"/>
    <dbReference type="HOGENOM" id="CLU_148208_0_0_1"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="128" mass="14655" checksum="F17B6E51BE7EF2E1" modified="2010-05-18" version="1">MGSVMAGTPDDTKGNETLDITVEFTFVPQERILYRSNRTNYTIAFRGGLEMLFSNQRVHKIALPSWDPSGSAANISFLVKYLIENVMKDPRKELFVVDDAVLAYHYWKLEGRYYGNEANIFNSDDLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEK3</accession>
    <name>D4DEK3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000298">
        <property type="protein sequence ID" value="EFE39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020345.1">
        <property type="nucleotide sequence ID" value="XM_003020299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584084"/>
    <dbReference type="KEGG" id="tve:TRV_05570"/>
    <dbReference type="HOGENOM" id="CLU_002093_1_0_1"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1548"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1557"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1744" mass="192835" checksum="911ADC3498B5A47A" modified="2010-05-18" version="1">MAEPWLDGLDDDWDSQQVVSATNSPVLPADCDEVDADTSPTPSPRPYRDSSSASNQPHSYHYSGQTSTVNSMGDGNGDGDGDGTMQIKSRREGGGNTTPEWKRRIIRGERALGEASDLFGPMGLETVFRPPSFSESLFQSHLSVPVAADAAARQDGVSSAREPFHSQRTNGTQRSQRSQRSLWSQRSQRSQRSQRSQRSRGGPFRDSHGGSDTSWMEHMSEVMIGGDGRPYTPHKNQAEGIEPLREHLSSLSIEFNSRLSSSSHASASVIRDNEASYISLPKRNQSSRSPTRLENMAACSDSRLQDDSLDADSENLTSISLPEGLSMGTQDCTSPGDALDTSRQAAYSDSDSIRIRTVSASSRPPHPQSSILEGGVPIPPVPQTPQTPPSIRLHSPPDVEQLAENSSKPRPSSSGSPLKLFGNHDTYTSNKLLRRMSQFEAANDSGADDASHLDAEREDMSPDGLPKLSSRTNISRSNHTTHLGMDNKQPRNLLQVPSSPQDKENSSPHQAYEKQLPPLSKTEAKRSLKRSSKITVSKRRRTLQVLPGQDQVWDESILDSTGPFSNHSLTEGMDESQQRLPSYSRPAAPTSTSFRPITANGQSLFAGPDKQETAACPGASFVFHIEHPRKGSITTQEYYNEASKVMDHIRAQGGPISGSTRRNEGYQTIYEDDSALYSDASSEEQFSRPPSRDGVDLRKQRELPPPNPRIISHLKKFEEKDEFHVGMGASVGTLKFRQQNGLLHPNQSPHRDAGYFDDTVESSPENIRIRSNVRRDGQQGELVLRSEESVKSQKSATSLPTGFSQGSANSSGAKGVISSDRVSHLIPENIGKMIFDRNTQCWVKNPARSDPDAHNRSQTVSEDDPFKDISDLSVDELKELALARGLMPAGTVFGSGPALPLPEESLPPEPEKKASFQAEHNPRPQTRESAQNPMSESSSVQSKYTRFTVSVPKPGTRATSWGSEEFQNHKISLEKPQVLDQEEQIEQQPDVYSGPLHEPNTRTRSGTITFSSPLVSGVAYQGEDELCSEHTQEAREWISDAAPQSPLGNVPPHDIPLPEQDCFELSCIQEGTEESIDDQGEEQNNDLSIIPSVADVDRSVMIAPPNLGSSNYSFHMSPLSEFTVNQVDESMRGERSYIAKRANPHALRQLHGKLALAAEDIVQHITDAEPYEAYWEQMRRLVLRGKRLLTLHQLDKYCPQLQELDVGENKLAHLNGIPATVRSLDSPYNCLSSLTSWSHLSNLQYLDISGNDLDNLDGLSNLYHLRSLNASNNKLTCIKGIFGLDGLLTLKVSNNQLTSVDFKHADLIRLSKLDLSGNDIHTIQNLDALHGIETIDLRKNQMQEFKVRRPLRRLDILKLSGNRLGQLDLSVFPSLRVLYVDCNHLSTVEKLEDCRFLDTLSMREQSIPSNDPSGSTSYAEPIPINLNLGKVSSIRKLFLSSNFLSADTLRPDTPILSLQLLDLASCTLEALPEQFGETFSNLKTLNLNFNALPDINGLRGIKRLNRLTLVGNRIARLRRMCKVLAEIGGAHGSLTRVDLRGNPITVGFYPPPVSGSGKPQQRYTGKNTQRDLIKHKADDDDLLNRSLPYIGGGKDIARHPSYHSNNYIDYPPLDAHEEQNEVENNEKEVDDPYTVPFADPFADAKYQAHLDEPTRLRRRVIELMIQNATSGRLTYLDGLPQCSSPDDNEINDDDGGGHVGPGDAHVHAHEGAVRVKKDWVWNRLEQLGVLRKKEKAKEKGNGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEQ8</accession>
    <name>D4DEQ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000305">
        <property type="protein sequence ID" value="EFE39675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020293.1">
        <property type="nucleotide sequence ID" value="XM_003020247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEQ8"/>
    <dbReference type="GeneID" id="9584032"/>
    <dbReference type="KEGG" id="tve:TRV_05647"/>
    <dbReference type="HOGENOM" id="CLU_018149_3_2_1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="393" mass="43419" checksum="338CF4AD3E3213AA" modified="2010-05-18" version="1">MAKSNVALNRAALNEFISMPVSCEMISYLARQSSMVIRCEDRAIRGPVTQQGTLTPPASPDLKAADEPHLPPLPPLESFIFSLVTRSHVEVPTLMTSLVFLARLKNKLPPVAKGMRCTSHRIFLAALILAAKNLNDSSPKNKHWSRYTLVKGYEGFGFSLPEVNLMERQLLYLLDWDTRVNEEDLFIHFEPFLAPIRSHIQAQCDMEMERERERERERELAVRAALAQASRDQSPARGPSDYGMQAGIYDSPRSIADNSSDRIARHKRRQSLQRSGRSISPPSVLDLPALGHADSNHGSSSRSSSLAPSSRGTPASINTASSFHEVVVADGSTSPSSSHLAYSYVDIQMMRPKPKSHAIHFPTEIQPQKRAKTAGSATGGIISRFFGKARPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DES1</accession>
    <name>D4DES1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000309">
        <property type="protein sequence ID" value="EFE39646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020264.1">
        <property type="nucleotide sequence ID" value="XM_003020218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DES1"/>
    <dbReference type="GeneID" id="9584008"/>
    <dbReference type="KEGG" id="tve:TRV_05661"/>
    <dbReference type="HOGENOM" id="CLU_064363_0_0_1"/>
    <dbReference type="OrthoDB" id="4185385at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055816" evidence="2">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="367" mass="40249" checksum="9852BE73C9BE0745" modified="2010-05-18" version="1">MLFAFIGLVATLTIWSSIASLPMTAVTPRDGFGRRLAGSITASLVTIGAYEVTKEVVITANKTSDYLYRYLETEDLPVEVLAPLPDSVSSRLPTFELWLAVPPAKLAYLHDLRNAVEKHDTLNKRTLWYLLNTLPSRCSSAAVAVPGATPTHRADSLSPANSLEFLSAGAYLGLILASLALGRCLGARYLVPASDDDSLALLPVGASPALPHRVVTGLQWEVRTEFVNGLPLMWASQPYISSELLCWIAETENLHLPTPQPDHTTKRQTEARPGPQRQALVLRRLANISPFVLIQIVRLLASALEGWTPASPESGSQPCLDSAEPLREPKKKKRNRPGQKQRRRQWIRDMHAMQDKAVQEAGGKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET2</accession>
    <name>D4DET2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000310">
        <property type="protein sequence ID" value="EFE39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020260.1">
        <property type="nucleotide sequence ID" value="XM_003020214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET2"/>
    <dbReference type="GeneID" id="9582801"/>
    <dbReference type="KEGG" id="tve:TRV_05672"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_2_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="270" mass="29196" checksum="E5578DC12EC7C79D" modified="2010-05-18" version="1">MAKKYLGGSGDKLTIWISIAASTVLIFYGYDQGVFGNVLIGEDFLQTMGYPSTNLQGTMTSVYNIGCFVGAMSTVWTGDYFGRPRQIIVGSTIIAIGGIIQASAYGVPQMMVGRVVAGLGTGMNTSTAGVWQSETSKMNSRGKLVIIQMANCIMGFSASNWLTLGFSFAKGSVAWRFPLAFQVFFTLCIYAMCPFLPDSPRLLIRKGQYGEALEVLAALEGNGATSTSHSVKTQFNVIKDVLDRENLNSYTWFKLLMGKGESSRVPSGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF65</accession>
    <name>D4DF65_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000334">
        <property type="protein sequence ID" value="EFE39516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025844.1">
        <property type="nucleotide sequence ID" value="XM_003025798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF65"/>
    <dbReference type="GeneID" id="9583904"/>
    <dbReference type="KEGG" id="tve:TRV_05810"/>
    <dbReference type="HOGENOM" id="CLU_047426_0_1_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="11"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="37243" checksum="44ADCF2C2DBEFD18" modified="2010-05-18" version="1">MASIPSSFTSKKEKILRDLSVPEEDYTDLSPKGSVDVAIIPLIRDINRLPGLVTTSSCAGRISVFVERGKGGKVQADITAPGTERALDGRENTSSEDKPGHDKHIRTEYVNKFVPKGGKGSGTWQFVSHDPLIFDEEKTDKSLHELFGLKPSRTAINPSGNGEIQLVKFKFEPMILHIMAASLSHAQPVLAAASNAGFRESGLQGLRCLEDPEACPIVAVRSSGLGLESIIGYIENDGSPEAIARSFVTEEYLQLLVQISNERFAVNTERMERFRVKLLHVGGGQALGNPNLQWEDPIARRARKRAEGLERGKAAKEARKPENLASVTDDDMIFGVNTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFF0</accession>
    <name>D4DFF0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_05897</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000337">
        <property type="protein sequence ID" value="EFE39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020036.1">
        <property type="nucleotide sequence ID" value="XM_003019990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFF0"/>
    <dbReference type="GeneID" id="9583804"/>
    <dbReference type="KEGG" id="tve:TRV_05897"/>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="360"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="529"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="63771" checksum="9746776D37BF551D" modified="2010-05-18" version="1">MDSAVQNPSPGENPAKQDPPTPQATVADQAGEQKMDSSATGRGGRNKQKDMGRKAYRRAANDRQEAKRRKLEQGENPMPIYATQFSQEDIDADVRRPKKKVIVMLGYSGTGYHGMQLCPTEKTIEGDLFAAFVAANAISKANAVDPKKSSFVRCARTDKGVHAAGNVVSLKLIIEDPDIVQKINEKLNPQIRVWGIIPATKGFSAYQFCDSRMYEYLIPSHCFLPPHPSTFLAQKMVEMAEKHGDMEAFKERQAEVESYWEETDKKHIQPIIDALPEKIKPYVQAAVGSVGSEEEKATPANNGSGETCEEQTESDTKKSDLTPDEQAQVNVAIKDIRTAYFKTKNEYRIPPERLARINAALALYVGTKNFHNYTIQKTFRDPSARRLIKSFKISRDPVVINGTEWLSLKVHGQSFMMHQIRKMVAMVALLVRCGADIKRIEESYQNSRIPIPKAPGLGLLLERPIFDGYNKKAKDLGRELLDFDKYEKEMDEFKLKEIYQRIFTEEAEKHAYKENTFLYVTSGGLAACSSSTTQPTAAQEEDARKAESKVLAEVESESEAELVDNGEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR8</accession>
    <name>D4DFR8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent protein kinase regulator Pho80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019918.1">
        <property type="nucleotide sequence ID" value="XM_003019872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR8"/>
    <dbReference type="GeneID" id="9584669"/>
    <dbReference type="KEGG" id="tve:TRV_06019"/>
    <dbReference type="HOGENOM" id="CLU_023749_4_0_1"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53925" checksum="BFC11E6C9DD8392E" modified="2010-05-18" version="1">MPIASSDSSSKKKKKEKDKKQEKKHSQTRSGGDDGLLRRLPVADHCRAATRLAELSNSNSSLQQRPSPLLASTTPRSSPRQTATSQQQQHSADSGSCSSPEIEQLRTTFKRQTVDAGTQYSRPSTPSDPAAAAGESSRMPGTAIGTKRTPPDATKVIAAPGPASTPALSKNPHSQQQQQQQQQQQQQQQQQQLPQQQQQQQQLPQQQQARQQNQRRQQLDDDDRPPEGSASKRLRPAKPPVKLLPRRYEAADPRDLVVLISSMIMELIRFNDQIPLRDGRLTRFHSRSPPRISVQDYLQRLTTHATLSPPILLSMVYYIDRLCALYPAFTISSLTVHRFLISSATVASKGLSDSFWTNKTYARVGGISVEELALLELEFLWRVEWRIVPQPEVLVDYYLSLVERCDDYEMQPELPPPIPPAVTAAGGARSIRAPATAPPAPRPAPAASSAPADSQPKSHVKPEPSTTTTTTAADEKTEPDSAQSTPSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ1</accession>
    <name>D4DFZ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019896.1">
        <property type="nucleotide sequence ID" value="XM_003019850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFZ1"/>
    <dbReference type="GeneID" id="9584647"/>
    <dbReference type="KEGG" id="tve:TRV_06094"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="76"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="377" mass="40946" checksum="4BEBAF6C76D3BD49" modified="2010-05-18" version="1" fragment="single">MKTSLQSIAISAVVKRLFIPRVYTHPPVNPAFNLKVQTGLHGFGYTTSAPRRLPSIYRNMTSLPTSQKGVLVSKIGGPEVLEYRMDLPVPSPKEGEVLVKNNLTAINLIDTYFRKGVYDSTKPEILGKEGAGTIVALGPGPNPYNFAVGDRVAWIGTAGYAEYSTPPAYRVAKIPQGVSDEDVLAVLLTGATCLSFIREAYEVKKGDWILLHAAAGGAGIIMTQLLKLAGAKVIGTAGGPEKVELVRGLGADVVIDYKSTEGAKWLDKVMEVTGGEGVNAVYDSVGKDTWEDSLKAVRRKGSVVFFGNSSGVVPPFPISMLAGKNIKICRPVLFNYIYTREEFDLYMNELFQLLEAGKLKTSIYKIYPLEDIQQAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG56</accession>
    <name>D4DG56_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019781.1">
        <property type="nucleotide sequence ID" value="XM_003019735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG56"/>
    <dbReference type="GeneID" id="9583704"/>
    <dbReference type="KEGG" id="tve:TRV_06158"/>
    <dbReference type="HOGENOM" id="CLU_564045_0_0_1"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53632" checksum="24FB337374267FDD" modified="2010-05-18" version="1">MTRHRPVKREEEKERKEEKKGGEEKLETTRQMLRSLSMDAQAAELIRLREAAAVERKQLLWKEERISILEEAIAANLRREGPTNPTGDPAPAAAAAQPTLAAEVGMPEASDEDWVCDILVDISAFGKELSFFAFVAGFKDKIETKRATSSAAATSRRFGPLLEETNTREETDGGQEETSHRALFPVPTRFMMEALLAHSFDYLSSYDQGKIRKGLRQVEGLLAQICLSRSKLTAAEKRRSMIPLDSTPSPPKSTSELSDDPAYREFYKLQDGFQWNVALRLISCLEHLLGRGSNGTNDLLIVSALDLIQGILLLHPPSRALFAREIYMNILLDLLEPANCPAIQSATLLTLVTALLDTPTNTRTFEELDGLLTITSLFKLRSTSREVKLKLVEFLYFYLMPETPQLPVVNASAPNTAAGLQRSPSKHGGPTSRSVDAPGRRRSAASADTKTTEEKQNLLGRYLSNVEDLVEDLKETAPFGSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGB9</accession>
    <name>D4DGB9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_06222</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000352">
        <property type="protein sequence ID" value="EFE39084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019730.1">
        <property type="nucleotide sequence ID" value="XM_003019684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGB9"/>
    <dbReference type="GeneID" id="9583633"/>
    <dbReference type="KEGG" id="tve:TRV_06222"/>
    <dbReference type="HOGENOM" id="CLU_001832_6_1_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="309"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="494"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="957"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113404" checksum="951F7BD67A995642" modified="2010-05-18" version="1">MSREESPKRRKIDSDRFAPSSPKSYTGPGPRHIFERRDRPPVNDDDDGQERPSRGRNGSSTPHQHAFDGPEAFVNDDDAMALDRDWYMGDESGHTFGDETHNPFGAPESAWADQIREAALSEKKNSRRFNARAVQKQKDVDAWETNRMLTSGVAQRRDYDADFEDDDDSTRVHLLVHDLRPPFLDGRTVFTKQLEPVPAVRDPQSDMAVFSRKGSKVVQERRQRKERQKQAQDATNAAGTTLGNIMGVKEDEGDSAAAIPGEEDQKAGNNSKFASHLKKSEGSSAFSRSKTLREQREYLPAFAVREELLRVIRDNQVVIVVGQTGSGKTTQLTQFLYEDGYGELGLIGCTQPRRVAAMSVAKRVSEEMEVKLGGLVGYAIRFEDCTSSETVIKYMTDGVLLRESLVQPDLDKYSCIIMDEAHERALNTDVLMGLIKKVLARRRDLKLIVTSATMNSDRFSKFYGGAPEFIIPGRTFPVDIQYSRSPCEDYVDSAVKQVLAIHVSQGPGDILVFMTGQEDIEATCELIHERLALLNDPPKISVLPIYSQMPADLQAKIFDKAPPGVRKVIVATNIAETSLTVDGIMYVVDAGFSKLKVYNPRMGMDTLQITPISQANASQRAGRAGRTGPGKAYHLYTELAFKNEFYIQTIPEIQRTNLANTVLLLKSLGIKDLLDFDFMDPPPQDTITTSLFDLWALGAIDNLGDLTAIGRRMSAFPMDPSLAKLLITSSELYDCSEEMLTIVSMLSVPSVFYRPKERQEESDAAREKFFVPESDHLTLLHVYTQWKANGYSDGWCVRHFLHPKALRRAKEIREQLHDIMKMQKMQLTSCGTDWDIIRKCICSGYYHQAGRVKGIGEYINLRTSVTVQLHPTSSLYGLGFLPDYVVYHELILTSKEYMSTVTAVDPHWLADLGGVFYSIKEKGYSARERRVTEREFNRKMEIETQMAADRQRAAELAAREAEKESAKKRQEIQTAVRRPTATPGIRKATGGLVTSGSVVKRPPSKRVGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGH2</accession>
    <name>D4DGH2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000357">
        <property type="protein sequence ID" value="EFE39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019696.1">
        <property type="nucleotide sequence ID" value="XM_003019650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGH2"/>
    <dbReference type="GeneID" id="9583596"/>
    <dbReference type="KEGG" id="tve:TRV_06276"/>
    <dbReference type="HOGENOM" id="CLU_2475149_0_0_1"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="88" mass="9387" checksum="4EAF8D2F7BB58CD9" modified="2010-05-18" version="1" fragment="single">MFGVSINRFGSSGSDLFANHAISNPIFCSMWRSVGFLVSLAVVLEGMTFVAFVVILAGGKQMRETGWKMLTVFLVLIGLVQAGGMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGQ8</accession>
    <name>D4DGQ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sister chromatid cohesion protein Dcc1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000362">
        <property type="protein sequence ID" value="EFE38959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019604.1">
        <property type="nucleotide sequence ID" value="XM_003019558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGQ8"/>
    <dbReference type="GeneID" id="9580139"/>
    <dbReference type="KEGG" id="tve:TRV_06363"/>
    <dbReference type="HOGENOM" id="CLU_054802_0_0_1"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="359" mass="39152" checksum="219DC62ED1740E4E" modified="2010-05-18" version="1" fragment="single">MDLRLTQTQPLQPVRLLELPPELLDLLESDHPPQLCLKSSAPTSTASTTTTTTTTSSSTTTASSTSTTTTTATATTASSRPGADFVNLCTPAKTFSLRQVNSSNSVFLIRPQVQGPGTAATVPTTTTTTPGITAVAQCKSTLEVQAMASSETALRPLLAALAVYDESDILMDERTEEDDHPLSPSEIVHERSKVFADIPFSRAECERAWKHICAFVHKNKESGAIGCHRPSARAKLMAWEKIIEGATLHGIDLGKQFLVEDLWSAVIEEAEHTVIDEYPFPRSLFDAIVRRLVDNSPIDGDLKWANLDQHITAQWTAELLLESSNGTPKAVLNVDTFSSDWKDLLPEQFRSYASIDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGR8</accession>
    <name>D4DGR8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HLH transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019577.1">
        <property type="nucleotide sequence ID" value="XM_003019531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGR8"/>
    <dbReference type="GeneID" id="9578351"/>
    <dbReference type="KEGG" id="tve:TRV_06373"/>
    <dbReference type="HOGENOM" id="CLU_034677_0_0_1"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="477"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="547" mass="59634" checksum="D4299C95A6FB4AB0" modified="2010-05-18" version="1">MTETVSPFRRSLFSANPNSNSSHLGSGLACSMELGLSESAHHMKGSSTPPPGPFGCTYPFEVYEGEGEGRHKRINIEETRLTEADALISPQDTPFDSAPERPLGPALLDDSESNMLDNLFTSLNASQFDNNDFWLSFGEQNGAEPGSNFSWPELPPNFEGSATNLPTPQSHHPHPAKQSGTMSTPDRSTALSSDVLAAAQMLYQNGHDNLSALHNQLYAEHGLLNHNSNANYHTNSNIHFQQQQQQQHHHSHQIDAKRAQLGRYNDGSVPQKEFVVIPKGIHTTTMIFDPAAHRSPANDHQQPRMRASASKLGPSMLQWGSDSGFAHQGYRLPPGQPTVEETTENLLHNLECLEAQSSAANTRPSSPVRKLCDRKETASSLAASRNPVPPSYEDRPKKRRKSNNKIKEEDPELASALSSSKSPTTTTPTSSTTNYTSSSSTTATSFARPSSRKSKGSSPAGNGTTIKPVRENLSEEQKRTNHILSEQKRRNLIKQGFDDLCSLVPELRGGGYSKSTMLTQAGDWLADLLAGNELLKAQLADLKARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGY8</accession>
    <name>D4DGY8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-ketoacyl-acyl carrier protein reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019569.1">
        <property type="nucleotide sequence ID" value="XM_003019523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGY8"/>
    <dbReference type="GeneID" id="9578343"/>
    <dbReference type="KEGG" id="tve:TRV_06443"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25992" checksum="597A26722EA9F3A1" modified="2010-05-18" version="1">MAALNDIEGRLALVTGASSGLASRSVHLALTYAKNSDGMNAVVRDIKELPSSSNLHISVHQVDVGQAEQINRLFVEIPAEHGGRLPDILVSNAGYGVKIPQIWDISLEEFDHTINVNLRASFILVKGVVENMKAQKWGRIVFMSSISAHGGGVNGCHYAASKGGMTGMMKNLATRLAQFNISVNDVAPAMIGETGMIPDARAIPEFAGNIPLGRLGTPDEVASVVEMCVTTGYLTGQSILLAGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ7</accession>
    <name>D4DGZ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06452</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000366">
        <property type="protein sequence ID" value="EFE38870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019515.1">
        <property type="nucleotide sequence ID" value="XM_003019469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ7"/>
    <dbReference type="GeneID" id="9578214"/>
    <dbReference type="KEGG" id="tve:TRV_06452"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="577"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="867" mass="95823" checksum="2533CA2159CDBEA5" modified="2010-05-18" version="1">MSAVNSAATTFDRMNINSPSTPALSIFPNSSSLSLSQKTTGQGGVAVIKEGYVRCKEDKFLASWNQRYLVLREFRLDFLKNETGKSVLSIQLSNVMNVTRSEDTKMAFEITRVANPKDANARSPLGARDVATKTITCEVKSDDEIYDWIDKIYERCPGMGGVSNPTNFSHQIHVGFDPQTGAFVGLPPEWEKLLTASAITKEDYKKNPQAVIEVLEFYSDIKMREQNPQYFPGMSTPAPAPHNMQPLRSHGGGGSGGVAPPRPPPPTGLQRLDTSQSMRGHDDRSPGSGSPAPSSSQRKASDPADRPYDQQQYSQDRSKEMPHPDQRRRMEEEARRIREAQRQREEEQARREQEAYNASLPKTRVPIAQQELGGYGGPRESPSTSSSSRYNPSRPAPQAPSGDRARQPQQDSRQMTAQRPAPSPPRNGAPSSSSSPSHSRDDHSAQRSAPRPDQSRQQPSSSRYAGNDSRSPARTQPRQPNGSAASGQPPSRLPAPVQAVKPLNVANKHGATTTTNNNNNTNKANGVPDGVRQAEAALAKKPDPSRQKDVRMSTMSESEVMEKLRQVVSKENPNESYSKQRKIGQGASGSVYVARVKENASSPVARELYRTHGPRGQVAIKQMDLRSQPRKELIVNEIIVMKDSQHPNIVNFLDSFLQESSNELWVVMEFMEGGALTDVIEQNPVIQEDQISTICYETCKGLAHLHGQNIIHRDIKSDNVLLDRVGNVKITDFGFCAKLTESKSKRATMVGTPYWMAPEVVKQKEYGPRVDVWSLGIMAIELIESEPPYLNEEPLKALYLIATNGTPCLKKPEKLSKELKSFLSVCLCVDVRSRASSDELLSHEFLKNGCSLASLAELLRFKKNSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB9</accession>
    <name>D4DHB9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019408.1">
        <property type="nucleotide sequence ID" value="XM_003019362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB9"/>
    <dbReference type="GeneID" id="9580124"/>
    <dbReference type="KEGG" id="tve:TRV_06575"/>
    <dbReference type="HOGENOM" id="CLU_303488_0_0_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="623"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="834" mass="89077" checksum="7F4A27FCFBCAAD3E" modified="2010-05-18" version="1">MPSLSSYTPFESLLFFQSLATLKSRPDSFAPVSELLRNNPFIQQDVKYDANRLSPQALEELYTTLLVDGVRSSDDEASDHSHSAQETANLKKRKHAQAAQDGTARSHSAAMPDLVDKLYARYKERVTREIRREEQRYAEIKDEIRRLEAGEDLQKQPVTADGSNVASSTGAAATPPPKPEAAREKVPGRIPQEAVQAPAQTPTTAGTPQGVRPVQPTVGPPAVTAPQEAPIPSTYNFKPVPLANQAQQQQQQQQQQPPQASPPVSTPGANIYPNIQPFPPPAHPTSTSAASQPAYQNVPPPMPLNRATQQPSLQPPPPPNTTWNRTPQIPPKTVPQTVKFQPLLTPQTIPQSSYGHGSARSTPKPSNQARNKATPTPKPLAPNVDKPSIPPTQNPPPSAPPAIAPPPAGGVSIPTPLPTTTQPTVTPDAAALEKLKTQLPSFAQSIGKRPPRPSLVTPSGNTPWKIPGPISLPNEPGSPERPKSADISPISERALSPSGQEDVEQWTGQAARRKLDLGGAAPRESPKHAGDASSPSNPPSGRPRTRGQSIASRGEDTRHIKNELPSTPVGITGDDMDSGHYRAKRKRSPSGSFSLAHDQRPSDWLKDSQYVMCSRTFGRTCGPIMNDVAAHKYASIFAKPLTNRDAPGYKDLIYRPQDIKSIKSAIHQGSRAVAAALEASQTTEETPPSTTASASASAAAAGAAASGAGPSAKSNVLLATKSAELMPPKGIVNSSQLEKELIRMFANAIMFNPTPDHTFGPAFPMRTDSSSREGTRSAEPDEGGIINDTLEMYEDVEKAISTWRSAERPMDDAGGKAFLALKRGTPVDSNDADD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHE3</accession>
    <name>LAP1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable leucine aminopeptidase 1</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucyl aminopeptidase 1</fullName>
            <shortName>LAP1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LAP1</name>
        <name type="ORF">TRV_06599</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular aminopeptidase which contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="ACYE01000379">
        <property type="protein sequence ID" value="EFE38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019370.1">
        <property type="nucleotide sequence ID" value="XM_003019324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHE3"/>
    <dbReference type="SMR" id="D4DHE3"/>
    <dbReference type="MEROPS" id="M28.022"/>
    <dbReference type="GlyCosmos" id="D4DHE3">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9577773"/>
    <dbReference type="KEGG" id="tve:TRV_06599"/>
    <dbReference type="HOGENOM" id="CLU_025866_0_1_1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397766" description="Probable leucine aminopeptidase 1">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="373" mass="40788" checksum="B3BBED5D9920FF45" modified="2010-05-18" version="1" precursor="true">MKLLSVLALSATATSVLGASIPVDTRAEKFLIELAPGETRWVTEEEKWELKRKGQDFFDITDEEVGFTAAVTQPAIAYPTSIRHADAVNAMIATLSKENMQRDLTKLSSFHNRYYKADFGKQSATWLQEQVQAAINTAGASRYGAKVVSFRHNWAQHSIVATIPGRSPEIVVVGAHQDSINQRSPMTGRAPGADDNGSGSVTILEALRGVLQDQTIVQGKAANTIEFHWYAGEEAGLLGSQAIFANYKQTGKKVKGMLNQDMTGYIKGMVDKGLKVSFGIITDNVNANLTKFVRMIISKYCSIPTIDTRCGYACSDHASANRNGYPSAMVAESPIDLLDPHLHTDSDTIDYLDFDHMIEHAKLIVGFVTELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHG8</accession>
    <name>D4DHG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019343.1">
        <property type="nucleotide sequence ID" value="XM_003019297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHG8"/>
    <dbReference type="GeneID" id="9577665"/>
    <dbReference type="KEGG" id="tve:TRV_06624"/>
    <dbReference type="HOGENOM" id="CLU_049332_0_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33962" checksum="0873684E560304EF" modified="2010-05-18" version="1">MFMKVDMRMYEPGCTFDGVFAILSLFQVSPGEIYSMCCKFSEWLKPGGYLVIGVTPSTDLPLGEYIYDSTWDCTRQMGKPWMNRYTDELFFSEERWKGILRSFGFEIESESRYSFTPKDVEFNHAQIHYLQLARKAENHQLLGPYPQPTKAELHRMPRACYFAESLVSEQLNIILGSFTEEEVLCLGCINKGRWRSTIYLIRKHAKKQLTRLEDWVSTKPNIRMFDGTIEKLPFSTEQFDIVLVSWQLEFAADMVSIVDKEELFSRLELHFCGSEHTIGHNMAMLDVSLTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIK8</accession>
    <name>D4DIK8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019005.1">
        <property type="nucleotide sequence ID" value="XM_003018959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIK8"/>
    <dbReference type="GeneID" id="9582329"/>
    <dbReference type="KEGG" id="tve:TRV_07018"/>
    <dbReference type="HOGENOM" id="CLU_004017_4_2_1"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="12">
        <location>
            <begin position="426"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="556"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="703"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="851" mass="93302" checksum="EDC50A569F3961DB" modified="2010-05-18" version="1">MTFSKFSMLTPEVATTAGGDAVTGSRSLLPSSEAEGWAGQPLPWNFSPTSSSHASSGNARSNTPPGHSTTVNPITRSETLSYLASAQPSASNMPNSNRVSNWSHYHTTCDSPASTTAFDNGVGRNSQHASTINGITNGSSAHNGLSAQEPQMNPFDHGNTLPFRENSRSNDQSSYFPPASSINLASMTPSSSHFGGGTPRHSISTGHGRPSLAEDELAAALSKIDVKVAGALAEHRQQALPPRPSFQQRASYDAVLSRANYNIEPEEPRTQYATYSRTISSPSVTLPSLIRRQDRTHPTLERSSIPGYYSSVDGQIQESMSQGVYSPRYRYAAGERSPEEQAELLAQGLRATLQQQQEQAYPSVAMSQLPGGIHLPPGYRYAAFQPPQPNGIHPVQLPLYSMGPFSPVSPSLIRPSTSDQDSNQVTRSPVLQEFRANNKGNKRYELKDIYGHIVEFCGDQHGSRFIQLKLETANSDEKERVFQEIRPNAVQLMMDLFGNYVIQKLFEHGNQAQKRLLAQQMQGNICSLSVQTYGCRTVQKALEHVLVEQQATMVKELEDSVMKCVTNQNGNHVIQKAIERVPNQHIRFIIDEFRGQIPRYATHTYGCRVIQRMLEHCPLADRLSILAEIHACTPSLISDQYGNYVIQHIIEFGEEVDKNKIISIVLGQAVHFSKHKFASNVVEKSITFGTMEQRLAITRILSAVNEKGEGPLLGLMRDQYGNYVIQKSLSVLEGDDYKMLVSRILPLMPLLKKCSYGKQIAGIEGHLHKYGNPAPSSPTSPAESGKPLGLDVDNNANSLAYTRDNSPVYDLSPVTADRSSIPSANTSVLEECPNEMAKEDGSAILKPAAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIQ7</accession>
    <name>D4DIQ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018935.1">
        <property type="nucleotide sequence ID" value="XM_003018889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIQ7"/>
    <dbReference type="GeneID" id="9582095"/>
    <dbReference type="KEGG" id="tve:TRV_07067"/>
    <dbReference type="HOGENOM" id="CLU_897079_0_0_1"/>
    <dbReference type="OrthoDB" id="4173026at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="31106" checksum="9F3243034B0965C4" modified="2010-05-18" version="1">MALERVDEEPGDSIAPFESSQDDDSSGGQPPPHVAILITTVIAVIIVGISLFWFVRWRSRRSRYRSTFTRRQASTRTGKSEISQAGKGSKSTANAKGGLEWNPESTFAKPSIPEPYVGKPYTHPQGMLSSSSIRKFWHNSIGGSRPPKLHIRGNPSTDAENELEGLSTHHRDGSGGNFLLRETITEIDKPPRIFPRATSTHSSSIFHLDRPSVGDRPVSTASTLDRNSRNTPTTQPEPMVSKYPWSVATQVTPIEPSYNSMTFFNHRESYGDSVRDIEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIY6</accession>
    <name>D4DIY6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000417">
        <property type="protein sequence ID" value="EFE38185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018830.1">
        <property type="nucleotide sequence ID" value="XM_003018784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIY6"/>
    <dbReference type="GeneID" id="9581392"/>
    <dbReference type="KEGG" id="tve:TRV_07149"/>
    <dbReference type="HOGENOM" id="CLU_050885_2_1_1"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="277" mass="30779" checksum="42E0390C1E7C5218" modified="2010-05-18" version="1">MAPGTAVSASSKKRRFQVPITQYFSPSPSQQTESEPSSHFNYNAPTHSAHPSLPPTIQSSLLAVGMRVRKAVPEGYRTKLIAKANNHQSKTTPRDEHYTDSSISPAYTELIPFSGAFKVGNYGVQSFPQPSAAVTEPMTAARQLDEESLPFSSQESTQSFESSSSIPRPNSYKRGFEIEEDDEDFDGQDSFPSRIHPSHSRPILLPRSGRQRTLRSKASSPSSSLLKGRSEQENWDLAFNFNNGGGGDFEDADFLKRREDVDEEYLRRAREVRMGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ05</accession>
    <name>D4DJ05_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">TRV_07170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018810.1">
        <property type="nucleotide sequence ID" value="XM_003018764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ05"/>
    <dbReference type="GeneID" id="9581370"/>
    <dbReference type="KEGG" id="tve:TRV_07170"/>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="42"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="51786" checksum="B7E7148226D4EF88" modified="2010-05-18" version="1">MSSLEIHRLNFLTRLSFTQGLLLGQLSVVLLIGAFIKFFIFGEAPSSSSRGISQRAAPRKRSYSANSTLFRDAASRSLKESASSNVLRPVPSSSTNTKSILRKTYYNAIPTNFQKNGRHRLHHSTHQPESLDWFNVLIAQLIAQYRQTAYLLKDSPTSSILDSLTETLNNVEKKPSWIDRINVTDISIGEEFPIFSNCRVIAVDDPNSDGGRLQALMDVDLSDDNLSLAIETNLLLNYPKPASAVLPVALSVSVVRFSGTLCISFVPSPGTTSESSPNPPSHSEGQNEPRPGQEDPGRPSSKDGVRSGIPKTSLAFSFLPDYRLDISVRSLIGSRSRLQDVPKVAQLVEARVQSWFEDRVVEPRVQLVALPGIWPRMGRTGVRAQEEHDAVSVDSDDPEAKAAQSGFTPVNANRDGPQTSRDLNMDGLRYRRGNGGGQSTADNYENLPQGDGHPGPTPGEQFRIPGALPGTSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJM6</accession>
    <name>D4DJM6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000440">
        <property type="protein sequence ID" value="EFE37948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018593.1">
        <property type="nucleotide sequence ID" value="XM_003018547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJM6"/>
    <dbReference type="GeneID" id="9584521"/>
    <dbReference type="KEGG" id="tve:TRV_07394"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_4_1"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="285" mass="31049" checksum="715FFC9EB53D7967" modified="2010-05-18" version="1">MVIHLIPKWGFNWTMRACALLILCLLLFTNFTLKSRLPPSKRRWHISEMTRPMKEPAFKALAAAVFFYYCERGYSIPLFTPLLANVHIGGMFLPVTYIVVAARKNGMSQHMANYMVPILNAARYEFTFYSAGHIMNIANSRGCSILGRTAPNVIADKVGRYNIMIIMCSITSLLILGLWMTASNNLAMILFAVFFGISSGSGVGLTPALVAQVSPMKEIGTRTGLIFAIGSLAGLSGSPIGGQIIEASNGSLRYMMVFAGVNCIIGTLFFVVARLSLGGIKMANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKP9</accession>
    <name>D4DKP9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018198.1">
        <property type="nucleotide sequence ID" value="XM_003018152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKP9"/>
    <dbReference type="GeneID" id="9579590"/>
    <dbReference type="KEGG" id="tve:TRV_07773"/>
    <dbReference type="HOGENOM" id="CLU_2428655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="91" mass="10545" checksum="7DFE38A4C95BFE09" modified="2010-05-18" version="1">MEDVVLRTYVQSEVYYFLFFIFLLSPELKYEPVRTDTLLWNGEVTGFSILASVTWAISHNRLTLNKGIEMAISSPMKEEQSPIESFTAYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ1</accession>
    <name>D4DKZ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018169.1">
        <property type="nucleotide sequence ID" value="XM_003018123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ1"/>
    <dbReference type="GeneID" id="9579540"/>
    <dbReference type="KEGG" id="tve:TRV_07865"/>
    <dbReference type="HOGENOM" id="CLU_049611_2_0_1"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="28716" checksum="583D6C49681C7603" modified="2010-05-18" version="1">MYNNLFAHIDIPPRNIHILDGNAPDLTKECQNFEAKIAKAGGIDLFLGGVGPDGHIAFNEPGSSLSSRTRVKTLAYDTILANSRFFNNDLSQVPRTALTVGIKTIMDAREVVIVVTGVHKAKALQKGIEGGVNHMWTLSALQLHQHPLIVADEDATLELKVKTVKYFESIELSGTDARTQGPPLVQFTKPYVPVAPPADLSTPVGSRKGLKIDTAFNAKDSDPDELTPDSMSSRIVDSAIAGLDETMTRGGDLIFDRMGSRIPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC5</accession>
    <name>D4DLC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017995.1">
        <property type="nucleotide sequence ID" value="XM_003017949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC5"/>
    <dbReference type="GeneID" id="9579123"/>
    <dbReference type="KEGG" id="tve:TRV_07999"/>
    <dbReference type="HOGENOM" id="CLU_000288_72_2_1"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="445" mass="48696" checksum="4A48BC5C569260F5" modified="2010-05-18" version="1">MEVAQDSISANEAVRKSAKRTHELFGSDYLSPVTPITSESIGVSYRRKKEYGDVQTLPPSLAEKQAKAATARGKRTKLKPEPGTSTALVKSAAPGGAQSSGDSAPTSLIKRLDISQQPKPDWHAPWKLMRVISGHLGWVRSLAVEPNNQWFASGAGDRTIKIWDLATGTLRLTLTGHISTVRGLAISPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLSLHPTLDVLVTGGRDGVARVWDMRTRSNIHVLSGHKGTVSDVKCQEADPQVISSSLDATVRLWDLAAGKTMGVLTHHKKGVRALTTHPKEFTFASASAGSIKQWKCPEGAFMQNFEGQNAIINTLAVNEDNVLFSGGDNGSMSFWDWKSGYRFQSLDTIAQPGSLDAEAGVMASTFDKTGLRLICGEADKTIKIWKPDDEATPETHPLDWKPTLGRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLH9</accession>
    <name>D4DLH9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017933.1">
        <property type="nucleotide sequence ID" value="XM_003017887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLH9"/>
    <dbReference type="GeneID" id="9579817"/>
    <dbReference type="KEGG" id="tve:TRV_08053"/>
    <dbReference type="HOGENOM" id="CLU_007122_1_0_1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="921" mass="102219" checksum="F851DCB1D7634176" modified="2010-05-18" version="1">MQFFHKNKSQPTLLNSVESAPHNTNDHSSVNSQNHHPHHNREGSQQHQYQQQQQHQPPQQQQQLYQQHQQHQQQHPANPHPQHTFQPATGSHELPSGTYQLGQHSNAASYTHPAHAGSRSENFSLPLQVSSGSAAAPHPSAAAAAAGGRPTLNLVPSASHQPDHSIDALSAAPSLPSAPHSTEASPLTETQPRKSRRSFFSLHSKDKDKDKSSSQNPAKPGRNVSVRKKISNPIPHPKPYQVGPLPPSDPALDPEEIDITEKKLPQLPNNSSQPSLPPSIYPARGASRSSSHLDIQPFEPPQIQRVSTEPLGQHEEYYKGRPQQYNQYQVVGASPHQQQQLQQNPQFQIDQPQAQPAVTSTATHRPNQSSDQVSIPPRYSPKPDPYHPPRPPSQQSLGPPSPLHPYYQSPDSNYQKPHYRQSLQPVAGPILSQSGMALERPTGLRQPIDTSQQQQQQQPQQQQQQPPSQQQQQQQQASGQQQQFPPSMPQGQSFKGNSSQSATPGDREQETPPPPGKAKDDASELDVNGWIQKYEELQLKYNRVKRYYFDKEAQVQQLQNTVAHQRMSASRTVLDDNEYATRLGRLDGAINNLSFNIRKDWKNIPPWLQGVVNEDAHTVGTKEMTAVGRACLTRWIVDELFDRYFHPGLEPNLSRQLKQIERNVRRMGKFVTEEEQENHLSKVSTWRRTTLDGLGDIFQSKLADEHRTLLTRNLVEKLTASLEMNLKTPPPPGLENGVAMIVELAVGISANIPLESRDIFIEYFLPGATITDSHMKIETSLPPLSNPGIEPRLGSEPSSAATDRVDQSSIKGIEAAISSSEATAGDEKDSNFPTQPQPASQGRKKSVFGSLISKKPHSGPGNSTDSMRPPSGHFREREEAVEAAREKENENRIRFAAFVAVEVRGKGAGNVIVKAPVYPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ6</accession>
    <name>D4DLJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex subunit Nup192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_08070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017904.1">
        <property type="nucleotide sequence ID" value="XM_003017858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579782"/>
    <dbReference type="KEGG" id="tve:TRV_08070"/>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1719" mass="192212" checksum="9F98D0419A8DAD56" modified="2010-05-18" version="1">MEGDESSGNLRGLYQDLSASSRFALPNAERLVAELEATLEDFRRLLDKPAKNNDSRKTVLSGKIKLDDVEYEVNAEFQQEVLQVADALDVDEIEAARYYIRAQSDAKKLDRSPIVSSIIRFHEQREFVLECLRLILHESFEVEREETQLLMKEYVASVLEIQNGPLRNGSLFARKCMDAMTDIEKWLVLLGEQIQKASIVGQSQEADILEVIEYQKQSLGKQHESLGAIVSYLFKGTYTSSEDFRKLMEKTKKVDKFDMLLVHYVPSIITAASQYGSSEGQGIEDARSLHKVIVESKDSQGWVLPQFHAATIVFWLAEYSGWYFDSTAAGPIQGLNSAEESAKLSKSLLAALEDGGFHFILSICAGVGLDEWKNAERNELVTLLLKDAARLTLEPDAPSPYFHSLLMESIEGFTESLIANMPDAIRMLKSEEDTQRLDQITALRDSVSPNLHRGPVEVRMHLECLLTIIAFSFDGRNDAAQEFWLDPDGNLYGFLQWVSKRQTVPRASAFCEMLCSISGGEENSAAAHKFLIDEDSLSSAKFRRSASMNWTQMFAEIQLYAVRITERPSTTQSSTLRLRKLEVPDIEEPESPIMLTSYLRLISHLSRENSKIREWILQHQTTNLISVLLTLCGASIPQHLRAAIFVTLRCLMIDRTSAHSNEMWTSLDNCISGSGSLPLALSPLPPLSSPQVRNERHAFQRITESFDQMNAFVEMLNQLVGPVSDSLDSQLTLPFPESLGSTYRMPGIEPYVDYVMGQAFANRSVMAEDKESHLLQWNCMNFAATALESFNENLVSIVSQPSISAQPNWKVTFSTYLRLHPFSRVMEWLFNEDVLRVLFSCSHRDADGVSKASSDSILISSLVRSIDIMNLILDHQPTYFNIVRPIIKSSGQDSSFNIANSTLASFEDCVIDNLGLISDLCLYCGTGHPQLTLTSLALLEKLSASRKLNKSSNISSRWQSTNQMVEQLNSNVEADRVARSLASQIDVDIRELESGPESSGYLIKMGLLQLLDKCLKMSPEKPTIAHLLLGFSCLGNTLDIPPDGLFENGISLLHSILEFVKAYPLGMDGAVISWMIHLRCLGFQVLLNLWASPLSSNLTLPHLRAGQLLPVLFMSQPVVTAETLWDDFRTNEPDFWLSSSPSSLSELLMLRTLLYEYATTEVRAVYKQGSPSVQRDTLRTIMGTTSVEGDQSVEHPSLFDLFDFADIDVGFSYTWPELQFFGSVNVESCVKTEENGVVVLYDIEALQELLQLVKEDLVADGVVTSQNEEQIMAEKEKLLLFLSATNEFRYVQFNRFVALKAWTDLVTIITATCKMDPTYMASFIQQTLQLILPKFESSIVETPAEAIELAHLGETLIDKLDEIPTDTNGDVIDERLDYLFQVCTSGIPQTSDNITLRESLYQISSKHLARITASSSTDDRFKEHAHSTVKAAGPTLMETICDDAYGSSESCRVSALVLLNLLGILDQQRNSSLLVNLITHSNYLGMFLDVLRVMPSEFRNAKATGTLLIFCSINRAVSLTACYLDTAQLLLFYESQLSLLQQLSQTKAGASQLLDAGLFQAVKESQLFSADPDIGIGEANFNSWIRVPVTVFINQEFLLDIDNSDALQRYYELLLSVLQVIVSTIFSRGLHNQAICDQTRAFLSENRQSMVGIFKRCAKSGSSDDPSMKKCLDNLAKSYTALIASVDFLDVSAFPLLHLFPIYTHHPHAPEASFLHTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLM3</accession>
    <name>D4DLM3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000513">
        <property type="protein sequence ID" value="EFE37252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017897.1">
        <property type="nucleotide sequence ID" value="XM_003017851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLM3"/>
    <dbReference type="GeneID" id="9583791"/>
    <dbReference type="KEGG" id="tve:TRV_08097"/>
    <dbReference type="HOGENOM" id="CLU_2759629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="70" mass="7305" checksum="0401A21C3E8A59F4" modified="2010-05-18" version="1">MVPAVVAAAAGDDNDDDDVAVVVAGGVSVVVVVVDIKMFTHGKPLNYSPLGETGGQTTEIKQYERVTTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZL7</accession>
    <name>D4CZL7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE45008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025619.1">
        <property type="nucleotide sequence ID" value="XM_003025573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZL7"/>
    <dbReference type="GeneID" id="9581857"/>
    <dbReference type="KEGG" id="tve:TRV_00259"/>
    <dbReference type="HOGENOM" id="CLU_024079_0_1_1"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055865" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="29"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41405" checksum="A042E14DC9C5AC3D" modified="2010-05-18" version="1">MGKCGPSHCAWPALAALILGLGIGNISAASVYIAAEQCLAPAPSATVPDYVMKYAPLIWIHSQDPYQPSDIGAQLKNSIPMINHVAIPNVPTDITLNNLDQLNKLGGNKVCLTSKEGIQALPAWFRGVKPNKDGKTEGAVSSAIVVREHGDEGKTVDAFYFYFYAYNQGNTVLGIEFGDHVGDCQHAAGQAFQYSATDKRGVRPIGFSGNGTHAVYATAGLLVQQKTMCANLGRTHDHTIPGLDLPAGFLEDETDEGTLWDPTLSAYVYSYSSTTGLFTPYDPSTPTNWLYYQGHWGDEQLPDDAPGQIELFGQRKYSTGPDGPMFKELVREKVCPSGVKLCLVLPWVTAVKEEKRKQMLADLVKEELERESKKHSKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0I1</accession>
    <name>D4D0I1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025260.1">
        <property type="nucleotide sequence ID" value="XM_003025214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0I1"/>
    <dbReference type="GeneID" id="9580753"/>
    <dbReference type="KEGG" id="tve:TRV_00576"/>
    <dbReference type="HOGENOM" id="CLU_038616_0_0_1"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="43585" checksum="FDA9F389BE734446" modified="2010-05-18" version="1">MVDYIPPPEPRQLLAPLLACLPLGFAASRPPPVLLPLLSPVLRQRVQLLGAGSGTGSTSSAESWLRLLCWGPANAAEVERIVGEAESSFEPHPVSGEIEIPDDIIIAYRWLDAETLRCQLPLDEFGLTVVYVWCPLDQEGGGAGWRVAEVLPLDALRDEEGAWFRSIEEASEALRESTAKEPVKEAKASVPVIVHEDDNRDGEDEDDYWAQYDNVQSRTPANGAVSLGPDQHNGRGGEQMSDTAYYNQYSNVQPALDSDDPTIDKAEVGDSSLNGNTLEDIFKRQMGNIIQQQQLQSQSATAAAAPERGRQPAEEESELPLNHPRPASASSSNRSDAISKLEYSAECQSASEMAIRQHISTNVKSMFRLARAAGMSRAEYQAVITRELELLEMMENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Q1</accession>
    <name>D4D0Q1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025191.1">
        <property type="nucleotide sequence ID" value="XM_003025145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Q1"/>
    <dbReference type="GeneID" id="9580684"/>
    <dbReference type="KEGG" id="tve:TRV_00646"/>
    <dbReference type="HOGENOM" id="CLU_3320324_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="39" mass="4201" checksum="34B5193432F84793" modified="2010-05-18" version="1">MFRLDGGGGGGDDDDDDDDDDGYMKMISKGQTGRKLSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Q7</accession>
    <name>D4D0Q7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025170.1">
        <property type="nucleotide sequence ID" value="XM_003025124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Q7"/>
    <dbReference type="GeneID" id="9580663"/>
    <dbReference type="KEGG" id="tve:TRV_00652"/>
    <dbReference type="HOGENOM" id="CLU_1688008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="156" mass="18668" checksum="DB26EA93465FBB17" modified="2010-05-18" version="1">MGRRLKERRRRRAQDEEDDERKAKQQQQLEEGEGEEEEEGDDNGRSIAGRCKAPHRRWFLFFSLLLLLISRRRRGLTWDFFFFDCAIPGWLLSLSLSLFLFFFPFFFFYSLLFFRRLLRLFLANQGQQDFPLPRIAAATRSIAGPDEMHNGIHIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R6</accession>
    <name>D4D0R6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000041">
        <property type="protein sequence ID" value="EFE44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025164.1">
        <property type="nucleotide sequence ID" value="XM_003025118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R6"/>
    <dbReference type="GeneID" id="9580661"/>
    <dbReference type="KEGG" id="tve:TRV_00661"/>
    <dbReference type="HOGENOM" id="CLU_611378_0_0_1"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="507" mass="56853" checksum="4AFE7ECE9D0775A0" modified="2010-05-18" version="1" fragment="single">LPKNAITLKTVVMDPRNVPIPSFPTPVVDGDDVLYALQRRQQAWAFPRQSDAPPSFSQLHLQQQQQPEEQLSHFSAARQPFSLSSIHPPIQATPALEPPTPPRRQSVAQLPPKRSTIAQGRRDSTKGTGSNYTLACLNCRSKKIKCLLEEGGCKKCKKLGIPCPGPEVDERKRPSSKRHIRELHQRIHDLEAALKQSEALRKAQAQNFHTIRGIAQFSPPESPVSLLRQKVPDNIIARLCDGRYQLNYDSNGQLRYFGPTSSLHLTDTVATSIVRSWGEYPTTNPKIEVCEMDAETQEYLLNLYWKFQHTELQVLHKDAFLRDMATGQTKFYSKALLYCIMACAARISHRPEIRAMVLTPGLSASDELPPLFAAASKLVNEELKNPQITTIQCLLLLSVIYCAFSQDTKGWVLTDLGLHRDCSSFTDKFSPMDIEARSIAFWGCVIFDRLWSLYLGRQYCLRLDGEVTVPRPAATAAVSGMIATWEARLADAWSSLLEIVGFICEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1A7</accession>
    <name>D4D1A7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024936.1">
        <property type="nucleotide sequence ID" value="XM_003024890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1A7"/>
    <dbReference type="GeneID" id="9580427"/>
    <dbReference type="KEGG" id="tve:TRV_00855"/>
    <dbReference type="HOGENOM" id="CLU_029367_1_0_1"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="32325" checksum="BA6509379693975C" modified="2010-05-18" version="1">MSTHRIYVWLALLDIPPLPTDEYLSLVHRGRSPAYTKIRNDTFRTLATDPLFKRRVTEASLIRLLNAVAWKIHDSKTGTSSRQLSPSQQSNSRRTSSVFLPDGHAAAIDGQSPNPSDSAAIYVQGMNVLCAPFLYASRSEVEAFALFHHFITRECPGYAKSTMDGVHKGVKLVDRCLEVVEPKLANHLFSKGMHAELYAFPSVLTLCACTPPLPEVLHLWDFLFAYGPHLNILCIVAQLIRMRDIILASQRTTFTRKIILGGSKPASMHFLFYVSMLLDDDDDDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R3</accession>
    <name>D4D1R3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA:6-aminopenicillanic-acid-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024841.1">
        <property type="nucleotide sequence ID" value="XM_003024795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R3"/>
    <dbReference type="MEROPS" id="C45.001"/>
    <dbReference type="GeneID" id="9580319"/>
    <dbReference type="KEGG" id="tve:TRV_01006"/>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="40802" checksum="D6DE8492B1B84390" modified="2010-05-18" version="1">MRTVVCHGSPYDASKEIHGSLDFYKTLLKQKSSMSWAEVCRTALKFQPLLETTFPNYMQEIRGEIFVLSLTYYYISMLAWSGWHLCYTGSKFCSGAGVDVKSVLALNVRTEIAYGMFDDGCTAFSWRNPSASFLAQNWDWEDDQAPNLISLHIAPLDTSKPTIHMVTEAGIIGKVGLNSKGVGVTLNAIKAEGVDFTRLPCHLALRLALESSSRVDAIGKLGKVGVASACHITIADYTGGTGLECSSMDIAWLNMGDFMESRPDIITHTNHFVHNHKNGLKSVMFMPDSEARLARLRELLAQSGPKPEFERIEEILKDEKGYPTSICRQAKGENTTSTLFSIIMNLRQLKATVIVGRPVDPQGVLELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R7</accession>
    <name>D4D1R7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024845.1">
        <property type="nucleotide sequence ID" value="XM_003024799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R7"/>
    <dbReference type="GeneID" id="9580323"/>
    <dbReference type="KEGG" id="tve:TRV_01010"/>
    <dbReference type="HOGENOM" id="CLU_064787_2_0_1"/>
    <dbReference type="OrthoDB" id="4206194at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25399" checksum="B54C81799ACF2B25" modified="2010-05-18" version="1">MECHQSMPVLSMEAKEWNTAFISRDPSTSKLETRFSNRKLGGVHEIWHPNSVDCLTLTIVIQLSANASEVTVSGNRDSSDASTSLGPQATAILKIARFEWEIPRIVQETRAYKLLEESGLAPRFLGHVHEHGRVIGILVEKIEGREASIGDLPVCKDVVQQFHKLGLLHGDVNKYNFIIGSGTAKLIDFENSRAHLDDCSAMQSELDSLETQLQEKTGRGGGFMSIENPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T3</accession>
    <name>D4D1T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024796.1">
        <property type="nucleotide sequence ID" value="XM_003024750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T3"/>
    <dbReference type="GeneID" id="9580286"/>
    <dbReference type="KEGG" id="tve:TRV_01035"/>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_1"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000041">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="367"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="521" mass="56517" checksum="E31BA8A3D7F722E0" modified="2010-05-18" version="1">MAQSQKRTPPSVMETVTEQIGNTPLVRLNKLPKSLGIEATVYAKLEFFNAGGSVKDRIALRMIEEAERSGRIKPGDTLIEPTSGNTMNTLADDTFPLLGYKAIITLPEKMSAEKVAVLRALNATIIRTPNEAAFDSPESHIGVAKRLEKELPNAHILDQYGNENNPLAHEFGTAEEIWTQTEGKVNVVIAGAGTGGTITGIARGLKKHNSSVKVIATDPHGSILAVPEPLNQEHLNEPYKVEGIGYDFIPDVLDREIVDKWYKTGDRESFKYARQLIAEEGLLVGGSSGSAIDGLAQAARDGQIGKDDVVVVVLPDSIRSYLTKFADDDWLAANDLLPATAEVPQSPQLPPQGSTDQFGGAKVKALRLKPVTTVSANSPCSTAIETMRDKGFDQLPVLAAQSRKLVGLITLGNTLSWISRGRATGNTPVSDVMFDFSKISEIITDPRNLAKSPKATDDDIGKRKEFVEITMDTPLSVLNRFFEWNSAAVVTEKDESGHMKPLAVATKVDLLTWLLQQNKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T4</accession>
    <name>D4D1T4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024797.1">
        <property type="nucleotide sequence ID" value="XM_003024751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T4"/>
    <dbReference type="MEROPS" id="M76.A02"/>
    <dbReference type="GeneID" id="9580287"/>
    <dbReference type="KEGG" id="tve:TRV_01036"/>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="30122" checksum="D5C1C14D8D2541BD" modified="2010-05-18" version="1">MAESQTTGSDASDKGQKPTGFKPGDDILTHFRNIYAGVTGKMTPEGVEQFRLARDLRNEESDCRRCESQRDYLLNYSMSPYTPSSPVLLDLLLIWFIYLIGPVIRFLQDNIRQLGGDISSKNIYCRRCTARQGGGFDPEYGIQICANAMNSQSQLEDTLAHEMVHAYDHLRFKLDWTNNLRHAACAEIRASSLSGECRWANEFFGRFEFKLANHHQECVRRRAVMSVQARPACKSKEQALRVVDEVWESCFRDTRPFDEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1U9</accession>
    <name>D4D1U9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024769.1">
        <property type="nucleotide sequence ID" value="XM_003024723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1U9"/>
    <dbReference type="GeneID" id="9580259"/>
    <dbReference type="KEGG" id="tve:TRV_01051"/>
    <dbReference type="HOGENOM" id="CLU_059580_1_0_1"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="28606" checksum="368D213F283BF5C1" modified="2010-05-18" version="1">MAPAAAGRVEKRRGKRAAEEELDGERRLRKKFGRLRLGDGQAGVFFLGRKSGEFLKLLEANSLVDFYLSTDRLSEQALITPTTTTATAAAGGGRYGLEAQRQADGREHAGSPSKYTSSRASSNGDGMQVDDTKTRVYITDLEDEIAQIEEEESRQTFKVMPEMEKQLMSIPKSVLTHKPKEERNNELVLYRVPAALGIPAEQDSVRAVMTDARERAREKMAESYNGQAEEDRTPLPDMSVDGEQLPGYDSDPMEIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D211</accession>
    <name>D4D211_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024706.1">
        <property type="nucleotide sequence ID" value="XM_003024660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D211"/>
    <dbReference type="GeneID" id="9582881"/>
    <dbReference type="KEGG" id="tve:TRV_01113"/>
    <dbReference type="HOGENOM" id="CLU_031559_1_2_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="419" mass="48093" checksum="481CC133B513ACB9" modified="2010-05-18" version="1">MISLIPKAGIQLPIVIFLLILTLIITSQRLSASVPQIKLSLKAGLANTSSKGWTGSNKAQHKAPVAPTPITAEDVFIISNFTAGTPKPPGSNYTKALIVPRLRTERVDWINSLEDIKKEIYVVDDPLSFPRIPKNKGREAMVYLTYLIDNYDNLPEIMIFMHAHQEAWHHEEPLNRDAAEMVRRLSIERVVRNGFMNLRCAWAPGCPGWINPHNTQEDSAKPEEASVLKGWKDIFPSIPIPDVIGGQCCAEFALSRERAQAIPRSHLIYYRDWLLRTNLIDFYSGRVWEYLWHIIFTGQYVYCPAERVCFCDGYGLCFDNDKPFQEFKNLGNILYGLRLELDHWRKKEQEVASAKKEKNFTALAKMEVPRMTRKQQIEQEIQRKRAVFNEIRNAAFARGRDPRVRARIAGRPWKEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A5</accession>
    <name>D4D2A5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024639.1">
        <property type="nucleotide sequence ID" value="XM_003024593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A5"/>
    <dbReference type="GeneID" id="9582814"/>
    <dbReference type="KEGG" id="tve:TRV_01208"/>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="689" mass="78369" checksum="940AF9D1C81E5A8F" modified="2010-05-18" version="1">MLDARRPCSLLRLVSSLLFYSLLFVLVYSVFQGSSYLKGRHSRAVSLVRKRCIKRAINSGRRLANDIQRLSQRIVRNRETPPAEQGQETQKNRRDHDGDALRQTQAGRAAARAGRRLLPGQKLPPAIEQQRRRHQQRFVAAAAARHHHAGRRGLLLGSFRSMIKMPRGDPSSIPLIQHRFSGKEDEDARRLRLSRLEAVKGNFSHAWNGYKAHAWMADEVAPLSGLAVNPFGGWAASMVDGLDTLWIMGLYDEFAEAVKAIDDIDFNNCTVEEVNVFETTIRYLGGLLGAYDVSGQKYPSLLRKAVEIGQMLYVAFDTPNRMPIAHWDFKKAAAGARPKAADQMIVAEIGSLTMEFTRLTQLTGDPKYFDAVQRIMNAMEKQQSKTKLPGMWPFMIDAEAMNFRSSNRFTIGGMADSLYEYLPKQYILLGGASQQYKKLYKGAFAAMDRNIFFRPMTKHGEDILFPGDVTVSQRVPLSELRPEPTAQHLSCFAGGMVGLAAKAFQSNDDMDTARKLVEGCLWAYEKSSMGIMPEIMVTVRCQDRNDCPWNEEIWKKAVEDTYYTEGTDFYEYVAEQGLMPGFVRIPDRRYILRPEAIESIFILYRLTGDSSLLDRAWRMFDTIVKHTVTDIAHAALDDCTIPKPTKSDRMESFWFAETLKYFYLIFSEPDVVSLDEYVLNTEAHPFRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A8</accession>
    <name>D4D2A8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024642.1">
        <property type="nucleotide sequence ID" value="XM_003024596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A8"/>
    <dbReference type="GeneID" id="9582817"/>
    <dbReference type="KEGG" id="tve:TRV_01211"/>
    <dbReference type="HOGENOM" id="CLU_009768_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125451" checksum="7F3E4A2BEAFB639D" modified="2010-05-18" version="1">MMASGLDLTYLQRDDGDEPAASSMASGSVSGSGFRANTSDTTTNDTGYSTTSRNDFAGDSSTGIGAEEEQRQQDVYRSLYDNPGSCLMDETGHQPQHLQQHLQQQQQQQQQQHQQQQQQNDQFIEQQNDNTEQERPWTELKTKAGKERKRLPLACIVCRRKKIRCSGEKPACKHCYRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERVMKAIPKDEQRDMVAIGRATVKPLPPGHASRPARASLKKRTATEAFSAELSEWTKPLTLAMPNTQPGQAEQQVGPPGKGQDIRTDMPALHVNTEHKLLSQGVEFLPSMELQEHLAEVFFDCVYGQSYLLLHKPSFMRKLKADAVPPVLTLAICAVAARFSTHPQVNNTEPAFLRGESWANAAADIALARHDQPNITILTVFLILGLHEFGACHGGRSWSFGGMALRMAYALQLHKELDRDPLGQGGSASELSCTDREIRRRTMWACILMDRYNSSGSQRPPIGNEKFLQIQLPIKESHFWREIPGPTEDLDGAVPNPVPEGVGQLSNPKNNMGISAYIIRGIMLWGKIVDYLNLGGKAKDPYRLWEPESGYSQLKRLLKDFSSSLPECLVFNWENLQNYAVEKIANQFIFLHIVIHQNTLFLNRFAIPLSPRGRPPRDIPKQFLSEAGKAAVEAASHISMLIDQASGYMLTVPFAGYCAYAASTVHIWGIFSKNPQLEAASKENFRHTYKYLNKMKRYWGMFHYMVESSKERYRHFAEASLCGRTVPESMKDGNNQDVPIFQYGDWFDKYPHGVSKLRWEDPDIDVKKESGSDAVMSQQSDLQSVEEFFTSMSPTSPSDGPRKEAKRAGPTTPSEKARPKLGSRGNTKSQSSSNSVQSRMVTNLSSPERQQQPQQQQQHHQTPRSQPMQQPPSTHPVSSQIPAQQEPMPNHVTNSYTTYNNPNMYPADPSSYVSDYKFHAHPDPLPQLDRQLVYDAYAGVEAIPHHPIPMPSSNNPTIQSQHPAGPQPQPGHAPDPNISNSYWNNGNNNNYQSYDMQPPMNWNGELIQSSAWFLPFNLDPTGLDAHASQPGDPAGIPAGPSHSPPNPVVSSGMSMSESDYYGSPTIMQPVGMGLGMVEGVPGMPETLRERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A9</accession>
    <name>D4D2A9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024643.1">
        <property type="nucleotide sequence ID" value="XM_003024597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A9"/>
    <dbReference type="GeneID" id="9582818"/>
    <dbReference type="KEGG" id="tve:TRV_01212"/>
    <dbReference type="HOGENOM" id="CLU_1887257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="15091" checksum="AC116B9ECFD0C396" modified="2010-05-18" version="1">MVMIKVYKPSYMNLSCALFPFILFVQMTALRHTGQQRKTKTKTKTNTLSHLIIPFFIKLIDQAVLLIDIPLALSVIAASSISTSSTNGSYQPIPSTSNTAARRPVSELGISRPRLAEAKTVRHRRPNDYKHILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V6</accession>
    <name>D4D2V6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01412</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024449.1">
        <property type="nucleotide sequence ID" value="XM_003024403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V6"/>
    <dbReference type="GeneID" id="9579671"/>
    <dbReference type="KEGG" id="tve:TRV_01412"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="281"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="700"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="816" mass="92503" checksum="1593A14EB46E2635" modified="2010-05-18" version="1">MAKDHSSRNGKPSTKPTRQNPRILKRKRNEDDIASLKQRVAELDTKAVIESFTDLPLSEPTRLGLSASHFKELTDIQSRAIPHALQGRDILGAAKTGSGKTLAFLVPVLENLYRKQWTEYDGLGALIISPTRELAIQIFEVLRKIGRYHTFSAGLVIGGKSLQEEQERLGRMNILVCTPGRMLQHMDQTAAFDTGNIQMLVLDEADRIMDMGFQSTVDAIVEHLPKERQTMLFSATQTKKVSDLARLSLQDPEYISVHQTASSATPSTLQQHYVVTPLPDKLDTLWSFIRSSLKSKIIVFFSSSKEVRFVYEAFRQMQPGIPLLHLHGRQKQGARLDITHKFSASKNSCLFATDVVARGLDFPAVDWVIQLDCPEDSDTYIHRVGRTARYERNGRAVLFLDPSEEIGMLSRLEQKKIPIEKINIRANKQQSIKHQLQNMCFKDPQLKYLGQKAFTSYVKSIHIQKDKEVFDVKALPLEEYAASLGLPGAPRIKFIKGEDTKSLKNAPRRLQVVSSDEDDDEDEIAEGKKKKVKEPEVRTKYDRMFERKNQDVFTEHYTKLIYDEEAGDKDGGKANDATNGDDDFLAVKRRYEVEDNEELDGQSHNDSGIQVKEAAGGVRAVHIDGRAPLLIDSNRREKLLQSKKKLLKYKNPGKKLVYDDDGNAHEIYELENEEDFKKRGDAAEQRAKFLELETERARLADIRDKEIAKQKKREKKEQRRAKARAEREAAAEDGDGPVAYLAPYEGAEGEGGDVMEDEREENETRPPSKKQKKARDDHHDTSDRKEKKKGTKTTFDEPAEMQTLEDLEAFASGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3A6</accession>
    <name>D4D3A6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024286.1">
        <property type="nucleotide sequence ID" value="XM_003024240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3A6"/>
    <dbReference type="GeneID" id="9579406"/>
    <dbReference type="KEGG" id="tve:TRV_01565"/>
    <dbReference type="HOGENOM" id="CLU_094265_2_0_1"/>
    <dbReference type="OrthoDB" id="4174220at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055206" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="17153" checksum="33818E5965B4A2E9" modified="2010-05-18" version="1">MQFKTLSILLLSASAVIAAPQEEKRDIIDQATSGIGGIGSDIGDIATDIGNIGKSLTALFPSATAIPASVWSSLTDASHIKSFGSSLHSAISDHHAPAWFSNLPASAQSAVSSAAAGITSEIGEHFPSATGTPGATPTTGGGSHQTNTPNAAPRATALAASIAGAAGLLGLAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3F5</accession>
    <name>D4D3F5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurofilament heavy polypeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024264.1">
        <property type="nucleotide sequence ID" value="XM_003024218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579384"/>
    <dbReference type="KEGG" id="tve:TRV_01615"/>
    <dbReference type="HOGENOM" id="CLU_231989_0_0_1"/>
    <dbReference type="OrthoDB" id="5244639at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF4">
        <property type="entry name" value="PITSLRE SERINE_THREONINE-PROTEIN KINASE CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1737"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1880"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1899"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2025"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2094"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2161"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2251"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2279"/>
            <end position="2288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2318" mass="250758" checksum="092A80521FFD1FE3" modified="2010-05-18" version="1">MACADVEMLDTWSPLCRVGDTPLVDGDLMASERRLRHRSTVEQLPAWSSPTAGNITRCISPKVRTILFDSFYSLFPPILILFSLRPLLTVTRYAVCMFHHLWLNDFTARTANEPFFFFFSSSSSSSPLFISVPDDLRAILEAAFSTPEASPLPSYDDAILDLPPDYACDEYARAHVDTHAGPAPARHRSTKKPSSLFQDPLMNISVDFKDTSRFREAKKKKPAKKPAPVADPWADTTPEKDSGAGQEEKDASGGGADGGDGGGDNGGGGGGGDDAGGGGGGGGGGGGDDPGGNDDKGGGEEDADQGSSKKKKKKKKKQEEEEEKKRQEEEEEKKRLEEEEEKKRLEEEEEKKRLEEEEEKKRQEEEAKAKENAGGDLSWADDTNADTSWGDFGAATTSKKKKKKGKNAATELPPPDPAPSAFQDVSLDDGAGAPQIGMSFGGEDTKGSTGFSFGGWGKDWNTGGELDLGANGGDTKDDGLNPWGGTSKKNKKKSTGSDAFDFGFDSNGLDGNNADPAGDAGADKEPDNSWGLPAPTTGKDKKKKKKGAAEPAATEEKDSGGLGDWADLAMPKKGKKKTASPWGLGDDKANDGDDFFADLGKKDKQADPEPEPEPEPAPEPVAEEKPAEEDPWGATPAPLSKKEKKKKKKKGAADPEPEPEPVPEPAPEPVKEEEPVKEDPPPPEEEDWGGFGVTSSKKDKKKKKGASLLDPVPEPEPEAPKEEEKPAEESFNSWDAIPAPTTKKDKKKKKGAAAAEPVIAEPEPVPDPEPVVEAPPAEEKPEDSFWSSLATSSSNKKDKKKKKGAAAEPVIPETVPEPDPVPEPEPVVEPAPAEEKKPVESAGWGFGLPSTTSKKKKKGSAADPPPPPPPPPEPEPVVEETKEEEPESFWGFSTSKNKKKKKKDEPEPAPVEAEKSKDLFDNDSWGNEFDQDKSKGTDLLDDPPKTETTSWFGSLTSSKKDKKKKGKTADPVTPGAFDFGDDPALEATGAGDEVDWFDSGKKSTKNEDPLDIPEFIDEAAEDTMKKEEEEKKPAVKETKLSKKDKKKKAAAAAAAAAADPVPEEPPAEELPKVDFFEDTKEEPDLLAPPPVDDFDSWGTGAGATTTKKDKKKKKGAATALPDPEPEPAPIAEQTESNDVGFGWSFGGTTSKSKKGKKGTTVEADAASKAPEKDPFALDDLLDQPAADTKKKKKKGAKSIIDEPAVAAPDPEPEPVVEPEPEPQPEPEPEPEPVQSSSWSLWGSSKPTKEKKSKSKATVPEVKEEPEKAAKGKKGKKVAEEVIDTTPQDDGVGSGELVPVPKTQDESTWDIWGTITNSKKKGKKGASELPPPAPTPPEFPPEHGGDGMGDTWDDITAPWPTSIKKGSLSRTTTSTSKASHIEESKLSKTRGKGLEVVDVSETPNLDTPAEDVSAAKAAKGYWSSFGLASGGKTSSSKAAKGGVDAPADDLLDLVEEEEPKPAASKTTSKAEKASAKASKKEKKEKDAKKEKKMNVGDQEVKEDEGSLEAASAPAADKATKQPTSSATATTSAPKAPGKSSVAERIKQLEQKKADKEAAKAPKTKEKAKPEPPPPAEPVPEPEVVEPVEEPATKAAKSSKKDAAASKTKTSSTSKTKTKSKSKKAAEEDLAPEPVPEPEPAVVAKEPTPRDSVPGSFPGAFDELADIEEHEQPSKAEEAAPPPPPEQEAAELKELLSDPDAGSSQRPSTAKADGDVADEMPGATPKKSTKKERARIDRSSGAASWALWGAAGASGPAPKKSSKKESKSKDPGEPVVKKEKEREKDKDKEKPPGLSRSKSSATKKEKVSSLGAEVEKSSGSDKDKRASRPSKHSRGMSFPFMLSGPPPPPVRSKSTKRASASKPTSRRHSVELDDSGLLTPRESPDIPDKAARMMGVESSKRVKRSSSHKKKSERKHEITNILLSVPRDPYALDDDVEMLSPDDGLISPPGKSSKDPERRRSRKESKKHSSDPALAPSGEMPMGRDDFGVMNHSSREPVPLRRSNTSPKRPEGLFGFLSLRKPGARAPEVRERPKSRSRHESSRRETDREKDESRRRRRSVRPDTDGEGFTTDAMRTGNNSPTEEAEARRAKRKAERARLREERDERAREAEREGRRQKRHAREMEDLPHESKRDKKSDRRSRSERPPKDPLSPHESRRHRSHRTDDEGGKPRRRRSSPDHHRSRREKSSRHEQAVPYPAMVNGGKDKTSSWVKSQISDPPEVPPIVATVIDVPDPAREPQNASLSSDEEARRAIHRRSRRKSRPVDPMDVDFDRRPRRRESRREGRDPVRSNESSGDMDHRYGGMNTKRTSWFKKLTSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J4</accession>
    <name>D4D3J4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024155.1">
        <property type="nucleotide sequence ID" value="XM_003024109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J4"/>
    <dbReference type="GeneID" id="9579193"/>
    <dbReference type="KEGG" id="tve:TRV_01654"/>
    <dbReference type="HOGENOM" id="CLU_048618_3_0_1"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="39968" checksum="7BDD10E386F0A77F" modified="2010-05-18" version="1">MATRDTKRKVRTKRTFYITRYRAMSVAKHRIINGARISPPWDISPRDHGEMSSPERQQPGPGRPLDVFTGRGMVTTPPTTYDRYSTIHPPIALEPIGELPRQNSSNGSKDPFMSYHNSRLSDPGMPLSLESDHSMGRMKKMNNQEHVDSIPRFHLRRKPGNRDEFDGPTQLLRMPSPGPAATEIPEKDLPHLPTSLNVQEQVKILCDINDRLSRCAFDFVAKYQFPIPLEPEKSEVRAPEDREWTEWVHLLRRLATKRRIPARVLYDGQIKQFITVLENSLEMRHTAKNQSRPLRDDRNILQLISAGTQVAKILKDAPAMEYFDFLYSRTERQIHERRNHTPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J6</accession>
    <name>D4D3J6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024157.1">
        <property type="nucleotide sequence ID" value="XM_003024111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J6"/>
    <dbReference type="GeneID" id="9579195"/>
    <dbReference type="KEGG" id="tve:TRV_01656"/>
    <dbReference type="HOGENOM" id="CLU_973834_0_0_1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31780" checksum="FE91AEB761777C10" modified="2010-05-18" version="1">MSLVNLAHVCSHLSNASKARLALTSIPNSNLHLALSNALVEAGFLSSVVRGGPTPPPQHMLLNIPAVNDELEPIEPVTQANIASRRLWLGLKYWQSQPVLSKLSMVSKPTRRIYVDTEALRDIVRGSKSRTIAGLRNPGECLFLSTDCGILESRQSLDPPFQLNVLLSLSLSLKLRHVLIVFRESYNALTPVGKNTKSHKTLWPDFLFLPAEMPILLLRIPVFMYLAASANGIFIEFILAADWLIFLLHPESQKYAREPARQKGKARSPPSSAQVKVNALSRLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3M4</accession>
    <name>D4D3M4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AmmeMemoRadiSam system protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024185.1">
        <property type="nucleotide sequence ID" value="XM_003024139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3M4"/>
    <dbReference type="GeneID" id="9579223"/>
    <dbReference type="KEGG" id="tve:TRV_01684"/>
    <dbReference type="HOGENOM" id="CLU_038085_3_0_1"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22554" checksum="106345254757F705" modified="2010-05-18" version="1">MVGSTSAANERVFGSILRPYLANEENAFVISSDFCHWGTRFAYTYYVQAPDPTTYKLPLTYPSLPVPSDMLTAEKAAEEVRAASSGRMLRENDKSYNKEKYMWAIHESVSACDMACMSAIASGNTDVFQEALRRTGNTVCGRHPIGVVMAGIEGLQHQAETTMGAAVTQDGVKKGKFYFIRYERSSDCFSVQDSSVSYVSAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3P1</accession>
    <name>D4D3P1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024143.1">
        <property type="nucleotide sequence ID" value="XM_003024097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3P1"/>
    <dbReference type="GeneID" id="9577140"/>
    <dbReference type="KEGG" id="tve:TRV_01701"/>
    <dbReference type="HOGENOM" id="CLU_627002_0_0_1"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="502" mass="55876" checksum="ECEB07C57D291256" modified="2010-05-18" version="1">MATLPLPPHRSLLHGVEQLPPYTPRRTPMNDPETASIHSDAPSYVSAAPSYHSYLPASHRRASDVLTGTPSPAESQPQHQPRQDTQQRQERQTARTQPAHNNNSNRHGLPPTPMYARGFENRIGPISPFSNSSNFTARSIRNTASSLRSIYNSSEWVPVTSGLQSRHYRNVANRRVTSSSSEINAISRFIFPGLFQTTTDLSTSSISETENRPSSSRNTTVPSSLGQAHNSSTVTLVRSPTEEPPTVSTANEIASPMHSGIHLPLSPHEDPDLVGEEAAARFRSQRLYMASQQEELNRVRYPTPPRSPAQQPEPPSQPGLVYQYSSLVSPASTSIEFTPSPEQQRRARMTGSPVSSDNLLLRPRPSRDRIEATRSQSPETQQLNIHPLTPTPTQTPATARNTTATLSAEAGPSTSTTARYNRRSVVDHDKLVLRAQEAQNWDFMLAQMADGEGRERSWKKRYKGQVEKQIHIARHLKLGPLLMVGWRRRLEERKKAKARAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Z9</accession>
    <name>D4D3Z9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024045.1">
        <property type="nucleotide sequence ID" value="XM_003023999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Z9"/>
    <dbReference type="GeneID" id="9582738"/>
    <dbReference type="KEGG" id="tve:TRV_01812"/>
    <dbReference type="HOGENOM" id="CLU_027882_3_0_1"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="583" mass="63125" checksum="D8BF3045040CF3A9" modified="2010-05-18" version="1">MLHLDGSTLEGGGQLVRIAAALSALTGKPLSISRIRANRSGSKGLKASHCAAIKFLLDVCGGTAVGNQVGHHELSIYPRGQKTGRSSLQTKPEDSNANSDLRKSAASLQQLSLTSLYSSPRVTVKSEYDIRLSTPGSVFLIFQALYPYLLFAGACTPTIEADAGTSDTAREHPKGIRVNITGGTHVSFSPSYDYISQVLIPNFAKFGLPPLSMELKKRGWATGQWAEVGAVSLVISPLSANGTPPRSDTISSPSHDSGRAQAETPPVVFPSIELDAFDKGFITQIDVTILAPDTLAQKLLKELSAKSAKGRNRDKKLQKKAVLCHDPSGVRNPYREQETSEDGDEYLSNAGEQAACMGDACNMKQGPPQTAREFIQLETIRTLSRELNRQVNREQSVLPATPEIDDAEVDEMQSHRINIGDVVVNLHTSEATSHYSQTYILLVAHTSTGFRLGRDALYSSFHHGPSKSDSKTGKKARKGSARSSADSGNILLRMKGMIDQCVTDLMDEFESHPGDQGQGRRIIMPKKAVDVYMRDQLVVFEALGRLTHPGPHLSAGGEQRDEEGVSLHTRTAKWVCEQILGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D402</accession>
    <name>D4D402_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024048.1">
        <property type="nucleotide sequence ID" value="XM_003024002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D402"/>
    <dbReference type="GeneID" id="9582741"/>
    <dbReference type="KEGG" id="tve:TRV_01815"/>
    <dbReference type="HOGENOM" id="CLU_007280_0_0_1"/>
    <dbReference type="OrthoDB" id="4173373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="914" mass="100851" checksum="CC24E972A7F5DB34" modified="2010-05-18" version="1">MVSNNSSGNKRVRRSKSSASVQNRRPAMSEAFDSELAQLQALAAASLAMRRHDNRPSSSLSSSKKWYDHSSSTDGSYHQQPLSQPGDIKDESESYCRTSATESTILPRMSESSGVMEQNRPNICPASPRPSSYRRLRKSKSMFTTSHESERLCHGSGNNQRTSSGTSRLSRRTLRRSLSFFRGSSISKADKENHATVSTLPIELAREQFQRSMEEKRVANGSESIVTRSSRQVPKPFKKSMRSNGTNAGSTTPSRYASTGTHCGPKGRLFSFSIKNSIRRIFGRRPSSSREELPKQHGAHHDFGSFDVGSSEGSYFDESSDYAKYQEQLLSQNVANTAPSVRSMKSCSSMATSNSRVTSWTDSTAGNTLTMKQFPPLTRQGLDIIREDSDVYTPTPSPGRHRHDGYSIFRQPLDNTVDIDSQRMFSALMRNIDETKNRRKTNQAPLTKSKAKSSHDSSTNGSPLTIRAVKQSPNTPSARQSMSGSRASPSSRSLFSVRSSRTVKLTPQEIARKNEMVSRKRSDQTIRGLGRLDLSGTSIYENKPTREWQNEQLEMRDDTGSVIINISQEDGDIPPSPSVYSRTTEARSPYRLNVDSSDSDEEEPGTVTILDSQRLPYPPRRSSQAARGISSDWKTWMNSQMDLIDAAARSASLANPTYALPGHYREDTQINGPSPEELKRVVLARRKQSSRGVPSPSSTAGGRSTNGEPRVNITEALSIPNNNFSRPLRSSPNGNLSTCSTVVRKPSITTSAIRHPCTPLICDSEMTPSPLSVRARSMSRTPTTATVPPLQYNKTRPTEDGAILEDSSLINSGQSSEGQSGPSVSPICLNDGKRLLQEIQFNSVRPRREQTNGTKENKWASASYRQNGRPNYASKLNGLHSTISTKRMVDIFLSERSQPPRGSADDSAPEPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D417</accession>
    <name>D4D417_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024063.1">
        <property type="nucleotide sequence ID" value="XM_003024017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D417"/>
    <dbReference type="GeneID" id="9582756"/>
    <dbReference type="KEGG" id="tve:TRV_01830"/>
    <dbReference type="HOGENOM" id="CLU_1511680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="178" mass="20960" checksum="9AEBFFE26E87516C" modified="2010-05-18" version="1">MIVAVVVFIYIPSDRCGYQQEQDGRLIPPPHAASLSEPWFIFLPPANLSILDPLHITSSLLLLLLLLLLLLLCLFFFGVAGLPRAIIIDLPPERTVTLVTCHRAQQTDKQEGNRHKRNKKKQEKKQEKKKQQQKQIRRDENKNKKMKKKKKKKQKRRRRRFVSRGRSRMFDLNQDEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A4</accession>
    <name>D4D4A4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000102">
        <property type="protein sequence ID" value="EFE43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023931.1">
        <property type="nucleotide sequence ID" value="XM_003023885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A4"/>
    <dbReference type="GeneID" id="9582630"/>
    <dbReference type="KEGG" id="tve:TRV_01919"/>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000007">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="202" mass="22791" checksum="7185A6E8D0C8B47A" modified="2010-05-18" version="1">MGISRDSRHKRSATGAKRAHYRKKRAFEKGRQPANTRIGPKRIHTVRVRGGNQKFRALRLESGNFSWGSEGLSRKVRVIAVSYHPSNNELVRTNTLTKSAVVQVDAAPFRQWYEAHYGQPLGRRRQQKTAAETTEEKKSNSVAKKQAARVAVMGKVEPALEKQFEAGRLYAVVSSRPGQSGRVDGYILEGEELAFYQRAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A7</accession>
    <name>D4D4A7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular serine carboxypeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000102">
        <property type="protein sequence ID" value="EFE43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023934.1">
        <property type="nucleotide sequence ID" value="XM_003023888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A7"/>
    <dbReference type="ESTHER" id="triec-f2pwm2">
        <property type="family name" value="Prolylcarboxypeptidase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S28.004"/>
    <dbReference type="GeneID" id="9582625"/>
    <dbReference type="KEGG" id="tve:TRV_01922"/>
    <dbReference type="HOGENOM" id="CLU_023630_0_0_1"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055314" evidence="6">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="536" mass="59846" checksum="ADA941F072378423" modified="2010-05-18" version="1">MVKLTACLLLLVAAVQAKLPVTPISQLRAESHRNKALVARSQDVNAAFPAHTIQIPIDHFPKSSRYEPHTTEKFNLRYWFDASHYKEGGPVIILHGGETSGEGRIPFLQKGILAQLAQATNGIGVIMEHRYYGGSLPTPDFSNKSLRFLTTEQALADTAYFSKNIKFPGLEKYNLTAPGTAHILYGGSYAGGQVAFLRTQYPDIFWGAISSSGVTKAIYDYWQYFEPIRQEAPQDCVHVTQNFVDIVDNIIIHGKNANTTRELKNLFGLGRLRDADFANALSSGITGWQSTNWDPAISGKSFYQYCGEITSDRYLYPVTAQQKASAKRIIEAGGHGREAPEILPQLLNFVGWLNKSTLESCSGQGQTAEECLNSYDEAFYKQDNADQSWRAWPWQYCNEWGYLQTGSGAPKNIRPVISRLIDLPYTSNICKQAFGITKPSNVDLVNKYGAFDIEYDRLAFVDGGSDPWKEAGVHATAARKRGTSTNKPFILIPDAVHHWDENGLYPNETTAELPPQRIKEVQAEEARFVKEWMKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4D0</accession>
    <name>D4D4D0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023895.1">
        <property type="nucleotide sequence ID" value="XM_003023849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4D0"/>
    <dbReference type="GeneID" id="9582495"/>
    <dbReference type="KEGG" id="tve:TRV_01945"/>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="163" mass="18567" checksum="792DB02DB4AC236C" modified="2010-05-18" version="1">MSSSTPVHEPTHRKRELPQSELEATAQLKLGEFQHVPTLSLSEARLVINKVLDLRRKGESKFEEREPSMMLTPISLAGRTLVKTQDYLEVFARFKEKENIEAVERLLSAHTELEFFERSQLGSLCCDNAEEAKSLIPSIGNKISDADLQELLDELTKLRNFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4R1</accession>
    <name>D4D4R1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000109">
        <property type="protein sequence ID" value="EFE43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023775.1">
        <property type="nucleotide sequence ID" value="XM_003023729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4R1"/>
    <dbReference type="GeneID" id="9582355"/>
    <dbReference type="KEGG" id="tve:TRV_02077"/>
    <dbReference type="HOGENOM" id="CLU_3015903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="56" mass="5992" checksum="D85C7E0BCE2AE47A" modified="2010-05-18" version="1">MVDDLGVNYLVVILISFFSSADGGGGAAAVFPRVVRKKRPVKGRVSVYSHRLAALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4T0</accession>
    <name>D4D4T0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000112">
        <property type="protein sequence ID" value="EFE43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023754.1">
        <property type="nucleotide sequence ID" value="XM_003023708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4T0"/>
    <dbReference type="GeneID" id="9582302"/>
    <dbReference type="KEGG" id="tve:TRV_02097"/>
    <dbReference type="HOGENOM" id="CLU_033828_0_0_1"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="464" mass="50630" checksum="9CC0094D5FDFA9D0" modified="2010-05-18" version="1">MGFITVNEAAIDKAFKTNPALQGRILEAISEYPQCVGLFEDIARFICSEREAHQSQLHSAYSIAPATESLQQQHITPVEGPAAKKRKVANGFAGSAAPGAMGGEDSALIAGIQGDADLQLYVQDLSFTIPQRKKLRLEFTQDLGGGNEYIRARNQASGEVEFGVPVGKIEHVLCLPVPEKAQRQFNFCIIPEYKDGITSAPDGVVTFEPIVWTVPDAPPRSAYLGSGTPVSESASLAETYQTYFQSFLDGKLKHVKVLCPDEKEFVSATPEAHRKSEKAYHVKAFRGSKEGYLFFLASGIFFGFKKPVLFIAFENVESISYTAVLQRTFNLNITTRSAAKPDEMQELEFSMIDQADYPGIDAYIKKHGLQDASLAEERRAKRLNINAPRGGDGADDGSGMNDGGVPQAEEEESELQKAQRELENQQADEEDEEEDDYDPGSEGESEGSGSSSEEEEGDDNAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Y6</accession>
    <name>D4D4Y6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000115">
        <property type="protein sequence ID" value="EFE43084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023702.1">
        <property type="nucleotide sequence ID" value="XM_003023656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Y6"/>
    <dbReference type="GeneID" id="9582252"/>
    <dbReference type="KEGG" id="tve:TRV_02154"/>
    <dbReference type="HOGENOM" id="CLU_2943489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="60" mass="6976" checksum="C6F10E6E7EDC1192" modified="2010-05-18" version="1">MILVFNASLAVFIVKRATIWRYRKGVENAMELLTEDERDWGNRTEEEADVSICVISSFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D569</accession>
    <name>D4D569_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023607.1">
        <property type="nucleotide sequence ID" value="XM_003023561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D569"/>
    <dbReference type="GeneID" id="9582153"/>
    <dbReference type="KEGG" id="tve:TRV_02239"/>
    <dbReference type="HOGENOM" id="CLU_006466_0_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126072" checksum="C00A7C72E805C63B" modified="2010-05-18" version="1">MFVDADPLALSAVTAHRYTQAQQGQTQTQTQTQAQAQAQAPAQAPAQTQGQERQPAQELEPSPPSSHSPSDEVQSPVKPDGSPKKRKRTRKAATGKKFECKHKGCGKSYSRAEHLYRHQLNHSPKQIYRCEFPNCFRTFVRQDLCIRHQERHNTHGSQLQKRDHVATQGPGAGSPSSARDTSNNPALSQPASEARSPAGSMPPHSRIAEQPVNGAGSNGFISVQGFLASNMAGSAASAGAVGAGAGAGTPTELHAGPLQTPQSIYHKGSADSIRRQSDGNTGGYLVPQQKAVYGEPNCSNYEPYNQTTNNTHNNTPQPSYSISPLNGTTEIGPGASVASESVQSRQQSISSPAGNHTVFPFGMPSGLLANGMATNTYMPQSQNMHMPAVLPDSGFTGSVLSRSHSQSSSGANLASTLSQMTSMPTTIHAETSVSNMDSVGPYALPVFGSEILNRSPFALTDDFTAWLFNESSNTSSAAGFPAVSTIMPNYLDPFSGQIQNPYYPTDSTAISGYVTGNPQQQQQQHHPMSVTSILDSAPPYSVMSEEKRSELLDLIQTRFNESGSGSLKSRKETFMEGNMDADNHILSLRMMQTYISSYWYHCHAQLPILHKHTFTPDKTPNLLLFAVMALGAVTLDNNRGQQFTDTASELANFICVHLRWELFMDPDFRPPAKLWVFQTLLLLETYEKMYSTRELHERAHIHHDTTLTLMRRGSSLIGRTAFNSPPSPSDNRQRPGVPSSSGSSEPVHFDESWLRWIKSEGTRRVAFAAFVLDSTHATMFGHSVKMAAHEMRLPLPCDESLWSAPCPAEAAKVQLRLNSSGFKPTMFLEGLKKTLTGQTVRTNAFGRTIIMAGLLSVSWHMNQRDLQVNSLGVSQVPGFRDKWRSSMLRAFDNWKRDFDESLANDPSPPTGSYSSSGGYQQRQQNLFEEDVFSETRNVLHHLAHMASHVDVVDCQIFAGAARLLGRAITPRDFSCAKEKMVERWANKDSARDATFFALKFLSQVLLRNNHARPGHQVTGSSMNVQEYCAREDFIMSRPWVLYFAALVVWSYGFALDGPIRPSPPELTTPEQQRHDMYVYLERVGGVHHPNDLEKIRDRNRCMGLLMVLRADFLNTRWELLHEAANLLGSCIEKLKGSSITIAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5A4</accession>
    <name>D4D5A4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023527.1">
        <property type="nucleotide sequence ID" value="XM_003023481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5A4"/>
    <dbReference type="GeneID" id="9576999"/>
    <dbReference type="KEGG" id="tve:TRV_02274"/>
    <dbReference type="HOGENOM" id="CLU_156753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11178" checksum="B6AD110339A815E5" modified="2010-05-18" version="1">MALPVADDDDLHKLNQEEREAEVRLATQKEHEMGVVEAIKLYPKATAWSLLFCMGVIMNGFDAQVIGNMFPVARFQRDFGYQFEGKWNISAAWQSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5C0</accession>
    <name>D4D5C0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023543.1">
        <property type="nucleotide sequence ID" value="XM_003023497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5C0"/>
    <dbReference type="GeneID" id="9577015"/>
    <dbReference type="KEGG" id="tve:TRV_02290"/>
    <dbReference type="HOGENOM" id="CLU_025631_0_0_1"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="445" mass="49012" checksum="54C3C00CEFDD740F" modified="2010-05-18" version="1">MAGLTCQTQASDGGISEDNAVSSPFIYIPKTQKKLNASSKEDYITSFLFEDERPFDASVGDETSYFPPFQVTDFERQTVTDLALPSRTYAATGSPVSAFSMSSADDEDVPEVQSLIRPPATTATPTAASARKPSDAGSRASSFSLERRRTSRGQASSSSRSTSSTRPRRSMQHLRGRSGAGPGTYTNYTPSRSDMGSNSQRNERDLVALHRESCLLFSQMGPYKELSSSPIERNSLSARHSHSHVPTASTKYSSAQQPQHSASASPLLRQENTPTSPFQSDGAPSPLIQQSTWNPIHDQTNNISSPPPLPKTVIDWTSPSTRRREYEKIDRASRGIRGAWRKFAPQWCQSKDARAPFFEECKAGHAKDDGSVRRFRMDIPEEEDADKSADQPPRQGLGVLRNGLVSALTRLKLENETAQPVKEKSAPIPAKQWRPFINRRNSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5I4</accession>
    <name>D4D5I4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023504.1">
        <property type="nucleotide sequence ID" value="XM_003023458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5I4"/>
    <dbReference type="GeneID" id="9583524"/>
    <dbReference type="KEGG" id="tve:TRV_02354"/>
    <dbReference type="HOGENOM" id="CLU_018012_4_1_1"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="52007" checksum="8C26CEB25E22945D" modified="2010-05-18" version="1">MLNKKLYVVTSAALVSTIQRSAKFVSFEPFLNEVGDWLAGVKGDGLKLLQEPIKGGGSLSSAMVHVMATAISGSGLDKMNDTMISFLQTSMEELSTATEDPIDLYAWCRDAITTASSEAVWGAKNPLRSKEMQDTFWYFHQLIYSWIGSMEYETNLLMLYINILPQFTAQKPFKARERLVKEFLKFYEANGQWEASELSLARWKIQHEAGATIENISRMEVTLCVGVLSNTVPTLFWTTFEIFSRPELLLKLRQEVWDNAVHVSINPEGNTVHTLDVADIRNKCTLLLSTFQEVLRLRSSSATIRTVLEDIEINNQYLLKKGSMLQLPAPFLNLEESTWGLDSANFNPYRFIDCDKEKVGRLRSKGYMSWGTSPHMCPGRHFASGEILPAVAMFLVRYDITPVEGTWQHPSINREVIAASIPPPKEKFLVRLSERDNQDALKWEFRPSAEHGRFKLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5J1</accession>
    <name>D4D5J1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase complex subunit Sds3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023511.1">
        <property type="nucleotide sequence ID" value="XM_003023465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5J1"/>
    <dbReference type="GeneID" id="9583531"/>
    <dbReference type="KEGG" id="tve:TRV_02362"/>
    <dbReference type="HOGENOM" id="CLU_031130_0_0_1"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55106" checksum="B7542E1A6526942A" modified="2010-05-18" version="1">MAYPAAAPASPSAAAGPSTARYTDTPPPGQFPLSKRDKRRNALQDRVNELKEAFGNNRDYHFRQRVHELQNEMALISNAQVYEDWPISDSPEDVAKQLTQLAASGQITSDTPISGRWYSNFVQEINRSKEERDAELAVMMNRHRDSLNRIKQERDFRIQLAAEEYKRLTETIRERLVQSVSHRKNRLMREKEQLDVADTNALLLHPNQFSIANPGSPGGIQGNRKTRHTRHRLDADDIGSGIMSEPINKRKRKAIDEEFSASPNHDGLSTPADRAKSRMSQQQNAPAYNILSLFTEKELAMHSNAAHVAAVHFLSASKRAKQANQNANGQSVDKDEASGSGDASSQEDATPGAADMERSASQNVHATRSTRTNGTGALNLLGELTEKNSTRTNLPYYILGSYHQRPNGSSSAPTPPALMPEEIEDDLARIERLRNTKPPGWIDTRLVNSLLTTLMGSDDEQPPARNNNNPPKVGSLHPDFPPTMDVHLVRANPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5X9</accession>
    <name>D4D5X9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023400.1">
        <property type="nucleotide sequence ID" value="XM_003023354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5X9"/>
    <dbReference type="GeneID" id="9583420"/>
    <dbReference type="KEGG" id="tve:TRV_02502"/>
    <dbReference type="HOGENOM" id="CLU_336144_0_0_1"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000748">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="569"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112969" checksum="83B7C0D53F43FF2D" modified="2010-05-18" version="1">MAPRLRSSSRTTSRNNTRPSSPHSAPASRPSSSSTSDTARPKKQRKTGTETRTPVDVVEEEERQAERKPAGSQMDTVLEQPEQAVGPQMAVLPGSQQLATAAGLSQSQDTQLAGQSSSVLPAPEQSTETEQPVPAAAPRADEEIWVEPPVAIPKTTCRGYGLNRGGPYGSMLPLGTRPTLAARRRVGLEPPAPTTTANRVTKRKGGRAAKPKQTTKNADERPSTASTSAEEAAALSDSSRAEGIIQGVLEHEERSRQQPPAIRITRSRAAGKDKLDDSADSSQSAGPAVPSSRKYTSEKLMDILGSAISRAEESQDSKVAGGLRWIKEASASDPFLLGVLEGAINRSADAHHRSAFQALMKDAVKRAQAQPEQQQQLDDSAAATDMVRTASATTTSSLSTAKSLDADAFAPVAAEPDSGNAPTTTSAKGKGARAPRSRARGGRRRAGPSRANAAPPTNSAFSRKRKLEEDPEFSEEAVAAKRRALEEATIAVTDEAEESNVRTAMEPPQGWVFPGPSVPSDSEGQGSTRPVPVAPAPKDRAARKPTTVGGSSSKRVRKPRVQADEIDNIDFCRACGGNGQLLCCDGCVDSFHFTCLRPPVDPKSPPAGQWFCPACEKKGLLGGLAEVMDSVPQTGFSLPAEVREYFAEVETGPGGEYRDVRALPEGSTRAKPARGSRGGVVEEQDPLRILDSHGKVIACVRCGLTSENRRPVILCDYCPSAWHLDCLDPPMANPPRQKPGSDKPYHYWRCPNHLEDALEQHYPGRVRRPRNPKYVDIEVLPDADEESVIKELDQEAVVLRVRERGLVHGFITHVLSERAAEEEARAKEAGDETRTQGEGQDEVPPAVPTFSQLGSAEQDAVMGLMDISGNSGAKRAEQIMSGLIDGTPEGFRACSNELEILQAVQELIQCFVPVLLALVPILRNVLEESLDQYVYLMAVSAFFNRYGPILSTLSNWNDVPVSVLASSYPLAHSCLFLSARGNTQPIVTNLDVTVSPYRLFCMFLVDYRVKTGKPNNYHSHLLRRIFSGTSQHQPSRQQVSISNTFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D660</accession>
    <name>D4D660_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023249.1">
        <property type="nucleotide sequence ID" value="XM_003023203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D660"/>
    <dbReference type="GeneID" id="9583282"/>
    <dbReference type="KEGG" id="tve:TRV_02583"/>
    <dbReference type="HOGENOM" id="CLU_034380_0_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="458" mass="51201" checksum="5727008EC0E36721" modified="2010-05-18" version="1">MWLFRGAQSAIFYYAACTPCTEHLQKRKRKRDAARTAREAGRDALVTDQPVFYQPTPFSTNRYWSEEIALGPGPPARRGRNNNNHNATSRTGSQKNLAALEKEKPTVTEKAVLTGVLEDLPIAKDGSSNGKKNDTGSGLATRWNIVRYQRDDEVLWGCDGRASSTSLRVATRGSSKYSLDPPPEVHDVYPPIANALMRKEEIQWMLQPPPSAKVMEGKIRADPASRFSASSSPLLRGITQSPSNTGADTHGHQHHLSRPSPVQSLESASLRHSPTTKSRKSSTGATISRGLIPIDSLISLSNTTQSQDQQRSSLPRLSTTVRRQSSDRHHHQQQQQQQQLTLSPSNDSSTASPLELKPYVSLPSLQPPRTRQHRKYETEHRPTSKETVDSGKAFRPITPSSNNAHWLRATSRSKTSKLPFTSTVQLDNDDNHDSDHSLDDVEFDRLDRIRTYRWSMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D737</accession>
    <name>D4D737_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022929.1">
        <property type="nucleotide sequence ID" value="XM_003022883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D737"/>
    <dbReference type="GeneID" id="9576987"/>
    <dbReference type="KEGG" id="tve:TRV_02916"/>
    <dbReference type="HOGENOM" id="CLU_2741879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="71" mass="7679" checksum="275C3C5A6D09B4A7" modified="2010-05-18" version="1">MWGGGGRKKKKAKGRKKEYHVLPAGSGNSRSRKEKDEEDAKAHGKDQKEALVAALASTSNLISSLSNLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D748</accession>
    <name>D4D748_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022940.1">
        <property type="nucleotide sequence ID" value="XM_003022894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D748"/>
    <dbReference type="GeneID" id="9576966"/>
    <dbReference type="KEGG" id="tve:TRV_02927"/>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="GS beta-grasp" evidence="13">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="14">
        <location>
            <begin position="145"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="414" mass="45806" checksum="E4D8CB25B7A0556C" modified="2010-05-18" version="1">MGLDQRGKVLAEYVWVDAHGGVRSKTKVRLQFFYFFHFCFFFGIFFCCGVDPCSNSPGSCISPQSTPPYRQRSLLAGTLSRPVTSADELPEWNFDGSSTGQAPGHDSDVYLRPCAIFPDPFRGGDNILVLCETWDSDGSPNKYNYRHEAARLMRTHEKEQFWFGLEQEYTLLDADGWPFGWPKGGYPGAQGPYYCGVGTGKAQCRDIVDAHYKACLYAGISISGINAEVMPSQWEYQVGPCEGITLGDQLWMSRFLLNRVAEDFGVVISFAPKPIPGDWNGAGLHSNVSTAAMRAEGGMKVIEAAMKKLEARHPEHIAVYGEGNEDRLTGRHETGSIDKFSWGVADRGGSIRIPRQCAKDGKGYFEDRRPASNADPYQITGIIVETVSLPLHSILHSTIIVHYTNKSLQLCGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Q8</accession>
    <name>D4D7Q8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2828 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022760.1">
        <property type="nucleotide sequence ID" value="XM_003022714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Q8"/>
    <dbReference type="GeneID" id="9581450"/>
    <dbReference type="KEGG" id="tve:TRV_03142"/>
    <dbReference type="HOGENOM" id="CLU_011744_0_0_1"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="114"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="544"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="88116" checksum="B7A572681BD6718B" modified="2010-05-18" version="1">MEGQKTKTTSMDSSFPVLLPEDPTLHLEPAEFRKRIFASVAKEAKGKENSKTTDSNSALFAQTVPKATEAISAAQSSHDSSGNAFVDALVQEARNPGTQKVSLEELEAKNLAHTDNAGVTHASTESHLVDLFHTLDGEPNEEKLAILEPLLEKAWADDALVTLKIIWNCRSIHLGKGERSMFYVALGWLKNNHPQTLLTNLPWITRGVIEKTPVVIENQTLGVDDYEVVHGVSHGYWKDLLNLLALSANDQLGMKNPESVLKNRTKAPQETLEKLDIELPLRAKKIKVSAMDVNEKRAYLEIPREDRMKETHKIISVQREASKKRKRARETSHHEKLWKKFESDSFHRALHNTIARMFADQLRKDKILLEGGSKQQMKEISLCAKWAPSLERFHDKQTLIATTIAELLFPAEDIKKEGDTRETYLKRAREQYRASFLSPLRKALQVVERDISANNFTNLKYAQVPSLAMDLYKKLFAKKDHDNFLKYLLDVQAGKQTISGSVLMPGPLVHQWIHSRNDEIARLTLNSQWETLIQRIKDSGSLSDSIAVCDVSGSMMSLPVNGATMYENAIGLSLVLSTVTKAPFGGKMITFSESPRIVTINKDGNKSSFVEQVDKVQNMPAGFNTDFLAVFTKAILPLAIKNEVKPEDMVKRVFVFSDMQFDEARGNSDPWATHYQIIEKEYKAAGYEVPELIFWDLSQRKTGSAPVTQDIPGTALVGGQSQAMLKVFLEGGSFDDGEAEEEDEVEGEGEGSDGFEVIQKKKKAITPLSLVMKAIKHQAYDMLKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7W8</accession>
    <name>D4D7W8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022681.1">
        <property type="nucleotide sequence ID" value="XM_003022635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7W8"/>
    <dbReference type="GeneID" id="9581340"/>
    <dbReference type="KEGG" id="tve:TRV_03202"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="114"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="712" mass="78269" checksum="9532D4548DBC9F21" modified="2010-05-18" version="1">MPFMDQPETNGNGHLMEPKELWRPSIPESTQVYQFKNRIIQRHGLSLQNYDDLREWSIRSPALFWEEIWHYTGVKAHKTYDTVFDENAPLFPRPSFFQGSLLNFAENLLFPACNPNEDDIAIISATETTRESISWKDLRERVRVCALALEAVGVLEGDRVAGFVGNHANTLVAMLAATSLGALWSGVSTDTGVHAVLERLRQIEPKVLFVDNGAAYNGKVHPTQSKVTEVTANLECLDMVVVIDAVKDYPFEIPAASPPKGKSVALQDFLSSAEAISKPLTFKYLPPDHPVYILYSSGTTGAPKPIVHGAIGTLIQHKKEHVLHCDMRPGDRLFYFTTTTWMMWHWLVSGLASGTSIVLYDGSPFRPLDSENGKGDMAMPRLIDELQITHFGTSAKYLSVLEQNSLNPREHPFRPVTLKSLRAIFSTGSSLAPSTFDFVYSSIHPDIMLGSITGGTDIISLFGACCPILPVTRGEIQCRGLGMAVSVFDYAGNDIGVSGEAGDLVCLKPFPSQPVMFWPPGPVGAEKYRASYFDTFGPKIWHHGDFVRINPKTGGLAMLGRSDGVLKPAGVRFGSAEIYNVILKHFADEIEDSLCIGRRREGIETDETVVLFVKLMGTTPAASGTSTPVIVEEPKAISQDLITRIQAAIRKELSARHVPAIVDSCPEIPVTSNGKKVENAVKQILCGLNIKTGASVANAACLDWYRKWSNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8C2</accession>
    <name>D4D8C2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022516.1">
        <property type="nucleotide sequence ID" value="XM_003022470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8C2"/>
    <dbReference type="GeneID" id="9581092"/>
    <dbReference type="KEGG" id="tve:TRV_03358"/>
    <dbReference type="HOGENOM" id="CLU_045148_2_0_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="363" mass="40685" checksum="5C7B54EBBE672C9D" modified="2010-05-18" version="1">MSEDDGLTGAYKGANFAIKIIIGVFIGISWYNALELCVLVFVTFSHYRGLYFWSLLISATVGVMPYALGFLLKLYNLMDNVWLSLVFLTVGWWTMVTGQSFVLYSRLHLVIRDQKILRRVLWMIICNIFILHLPTTILTFGSNSSHQKSFVPAYKIMEKIQMTGFFIQEVILSTLYILETMKMLRIAPKHGNRKIMYQLLGINLIFIIMDLALLGTAYANLYVIETTIKALIYSVKLKLEFAVLGKLVHLVNIHSWNPEFFSGSNGYPDFVDPTQITTDITRPPQCINSPPRPPWSFPDTLPITSDLQFCGKADVAPSSSGSLATTHIAPCTSNGVPVPTPVDVTHATPSQVISPNNLPKWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I9</accession>
    <name>D4D8I9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022475.1">
        <property type="nucleotide sequence ID" value="XM_003022429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8I9"/>
    <dbReference type="GeneID" id="9581052"/>
    <dbReference type="KEGG" id="tve:TRV_03425"/>
    <dbReference type="HOGENOM" id="CLU_004962_8_3_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="42203" checksum="D7B76845415E4263" modified="2010-05-18" version="1">MVDPSVPQPGPARLKPNAGPDEWLEAAKNCKYLSEHHMKQLCELVKEYMMEAGGMPGDTRPAAPSTQAPIITSEDIEPPSTITDPKLKRRLRKSSPPNSVIEDDGDEETGGQATESKGDDETGEEDKSASPIGNFIFLGDYVDRGYFSLETLTLLLCLKARYPNKITLVRGNHESRQTTQVYGFYDECVQKYGNASVWKACCQVFDFMTLGVIVDGKVLCLHGGLSPEIRTLDQVRIVARAQEIPHEGAFCDLVWSDPDETEDLTWAVSPRGAGKIDLSLTAYMSFCPKERADEFCAVNDLNLIARAHQLVNEGYKYHFDSQAMVTVWSAPNYCYRCANMASVCEVREDLKPVFKLFAAVPAEMRHVPASRPQKAEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8P8</accession>
    <name>D4D8P8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022421.1">
        <property type="nucleotide sequence ID" value="XM_003022375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8P8"/>
    <dbReference type="GeneID" id="9580968"/>
    <dbReference type="KEGG" id="tve:TRV_03485"/>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000002">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="532"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="416"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="852"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1126" mass="129572" checksum="174B2F91BAE25376" modified="2010-05-18" version="1">MFIKQIIIQGFKRAFANGILYNSYKDQTVIEPFSPKHNVIVGRNGSGKSNFFAAIRFVLSDAYTHMGREERQALLHEGSGSAVMSAYVEIIFDNSDDRFPTGKDELILRRTIGLKKDEYTLDRKNATKSDVMNLLESAGFSRSNPYYIVPQGRVTTLTNMKDSERLVLLKEVAGTQVYEARRTESLKIMNETNNKRAKIDELLDYINERLGELEEEKDELRNFQEKERERRCLEYTIYSREQAEIASALESIDDQRQAGVEDTDANRNRLMQGENDIAQIDTQKAELRQQMELLKLEKDQLEDDRRDASRALAQAELQRKSLSEGQSAAQRSKAEREANVERVNAAIKEREEELSTLLPQFNEMKEQEDQAKFSLNEAETGRQRLYAKQGRISRFRNKGERDNWLQSEIQNTYAQVSTVKAVRMQTTKEIQELENDIALLEPEVEKLRKEADGWGDNLQSIDQEVQTAKDERDRLIDQRKELWREEAKLDSILTNATHEVERAERALAHMMDQNTSRGLAAVRRIKRQYNLEGVYGTLAELFDVSDRYRTAVEVTAGQSLFHYVVDTDETATKVLEILQKEKSGRVTFMPLNRLKPRASNIPRASDTIPMIEKLQYDPQYEPAFQQVFGRTIICPNLQIASQYARSHGVNAITPEGDRSDKRGALTGGFHDSRKSRLDATKNVAKWRDEYDAKKARGGEIRRELEKMDQLITQAVGHLQKAEQKRQQLHSSNGPLRQELKSKRDLLHNKTDALEAKRRALKNIEANIDSLTSQIAAHEEELATPFEKALSNAEEARLESLNSMVQDLRREHAALSSSRSELETRKSILEVELRENLYPQLDHLAGQGLDVGEETAQGNLKESEREVKKQQKALEKLSQKLQKLENTIEQQNNEASQLEQRRADIKRELEEFAKSIEKHQRRMEKSMQKKAALTAQALECSANIRDLGVLPDEAFTKFKNTDSNTIVKRLHKANEALKKYSHVNKKAFEQYNSFTKQRETLTKRREELDASHKSIDELIMILDQRKDEAIERTFKQVSREFARIFEKLAPAGRGRLIIQRKTDAATRQQEDMDSDEEEARRSVENYIGVGISVSFNSKHDDQQRIQQLSGGQKSIYIHLTLNYKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q9</accession>
    <name>D4D8Q9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022432.1">
        <property type="nucleotide sequence ID" value="XM_003022386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q9"/>
    <dbReference type="GeneID" id="9580979"/>
    <dbReference type="KEGG" id="tve:TRV_03496"/>
    <dbReference type="HOGENOM" id="CLU_2185857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="109" mass="12050" checksum="266881171B898EAC" modified="2010-05-18" version="1">MEAVKHTLITFRGRLSGWPVGRVLAGVTAAGFTTFIITRNFQTSSRMSQPATKAAFWKAGPSFLRLRLHSSEQVSPTSKRLRFELPTPDTISGLGLCCESTYFHSPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8T8</accession>
    <name>D4D8T8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">TRV_03526</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022315.1">
        <property type="nucleotide sequence ID" value="XM_003022269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8T8"/>
    <dbReference type="GeneID" id="9580862"/>
    <dbReference type="KEGG" id="tve:TRV_03526"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="283"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="542"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="780"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="643"/>
            <end position="645"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="650"/>
            <end position="656"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119608" checksum="8464BC9A74F18627" modified="2010-05-18" version="1">MPRKALDSRIPALIRNGIQEKKRSFFVVVGDRAKDVIVHLHYIMSSVDVKQNKSVLWAYKKDLLGFTTHRKKREMKIKKEIKRGIRDPNTDDPFELFITLNQIRYVYYKETEKILGNTYGMCILQDFEALTPNLLARTVETVEGGGIVILLLKGMKSLKQLYTLSMDIHSRYRTEAHDDVVARFNERFILSLGSCNTCLVVDDELNVLPISGGKAVAPLPPVDPEEEAKSPSKKELQSIKTELEDTQPVGALVKLAKTVDQAKALLTFVDAIAEKTLRSTVTLTAARGRGKSAALGVAISAAIAHGYSNIFITSPSPENLKTLFEFVFKGFDELGYLDHVDYTILQSTNPDFNKAIVRVNVHRQHRQTIQYIQPQDAFALGQAELLVIDEAAAIPLPLVRKLMGPYLVFMASTINGYEGTGRSLSLKLIQQLREQSRGGTKANGIDNTDITDRATGKPARKEGGSHPGGRTLREITLSEPIRYAQGDSVEKWLNKLLCLDATLPKSKLNTQGCPHPSQCQLLHVNRDTLFSFHPVAEKFLHQMMALYVASHYKNTPNDLQLMSDAPAHQLYVLVPPVDENATKLPEPLCVIQVALEGQISKQSVLNSLSRGQRAGGDLIPWLVSQQFQDEDFAGLSGARIVRIATNPDYIGMGYGSRALELLIDFFEGKFASLSEDENPASEEMVRVTDAELEESNLLDDNVHVRDIQSMPPLFGKLSERRPGSLDYVGVSFGLTQPLHKFWKKSQFAPVYLRQTPNDLTGEHSCVMIRTLSTGSNDASWLGAFVSDFHKRFQSLLSYQFREFPSVMSLSMSESATAVSKSDPSLKPSPVTKADIDAVFSPFDLKRLDSYANNLLDYHVILDLVPAIASLYFSGRLTPGVNLSGVQQTILLATGLQRKTFDDVEKELKVAATQLMAMFIKIMRKVSTHFRSVLEGAVADTMPTTNKAITQRETTDAHDDKIVEDRFRPLDVDLEDELKEGGREINAELREKQRALIDALPLNQYEIEHGAAGWEEAEKQIRTSSSKDGSIKTVSVKSSAKRKVGETARDIYEKEIGSKERKKIKKGTEGRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D909</accession>
    <name>D4D909_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022275.1">
        <property type="nucleotide sequence ID" value="XM_003022229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D909"/>
    <dbReference type="GeneID" id="9576877"/>
    <dbReference type="KEGG" id="tve:TRV_03597"/>
    <dbReference type="HOGENOM" id="CLU_058466_0_0_1"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="139"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="34810" checksum="9923CA4930BE4EBC" modified="2010-05-18" version="1">MAPNKKEESASFEAIIHNARLRRQKQALTDDFFGKARKSGTPGSNVSSRRGSPVTGSLASRVEKVSLPRDPCSLPNQNRVASAGVKKQQAKPTTTRQTRESRLLSGILPIIDNTNRTKTQGPGLNIKGRASGPCVVIGSNFAPGTTAEDIEAAFSPTGGDILQCRITKSYPSVTAQMVFAERRGADSVVAAFNSQKADGRVIQVRIDTANPATVLAQSNSASAPRTKSAFDSSRELADQERRENRRPAEFQDGRFGFADPAEQPRQQQPNSYDQDHRHNGQNWGRARRQTEKQHNSAKPDLYDTMMVDPQPSRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D912</accession>
    <name>D4D912_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022278.1">
        <property type="nucleotide sequence ID" value="XM_003022232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D912"/>
    <dbReference type="GeneID" id="9576880"/>
    <dbReference type="KEGG" id="tve:TRV_03600"/>
    <dbReference type="HOGENOM" id="CLU_323889_0_0_1"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="919" mass="104400" checksum="B5C7E2B201BAC652" modified="2010-05-18" version="1">MERVTESIMLLLFLPHSGRTIYIAKMHHWHEAGCQRPDVVIIDDTARCSSCLSRWSHEESVEVTSTLTVPHIESLSHLNLSWPETVKYTHPNTSYDDISIPSLPGSKPPHDPQLVPSVANTNSLDTCPEGYIRLLWLHPGQSDDPVRGDLMDLPFRDLDAPPYQTLSYSPFDDPTSISEDPSNEKLSEQKPQYSEEAFTNILCKPQPRNRPVYVDPSCDVIYVTKNCEAGLKAVRHLSAALPVWVDLISIDQHSNDDRSRWVASIKCVFANALQSMIFVGAPSGDSDIALDLLSLITSRRSVRSRVAATKEGPKSALKSLFKRPCFSGLWLLQQLIYAKHPLILCGDRSIPWPCFSFMPNGIRRCASLLLFNKDAWTRLIDKDYYNILCHALTHECLDPRDKIYAILGLLGETGISIDYSLPVEVVYTGITAYLLQNHLSFRLFDLLGADEHRLNLPSWVPDYSQRLQVDNSFDITTWVNDTDDQIEIGESKSVLILYPFEFHNPEELPVGLDQEVEIGSDGSLSIFAVKLCDIFPMDSVTKNPQNSQHFIVIDKGLHGHILISLKKKEYEIGDDSIFLLNESPYPVVLRRDPRKGTYSFLSLVSMALAYPNGDDVTWRLPCGQEHGTIWPFDVPLRVSQTTTQKIQEFYSSLLELCEVDPTQIPMDSDVDLVTAERKAVVDFGILRLTGFNTLEADLKSTWQGYKEKLGWMLRDQAAIWKFIRHTEQEHQKDWSGVGSMVVKERVGLLDNYATGIKTEYTWNLRQFFWSFLKPTALAPDLLEGVWNPAYEAIKSHTSDFQSWAEVTEKLMNAIAFSQTALGSSMKFFPGIDLPEKWSSNWKSFSVAREGGIFHDGEAFGSECSWNWSEFERCLDLRDTVLAQALPEELRPQENHEMQAHMSFRVWGLNLDQRRRITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Q8</accession>
    <name>D4D9Q8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022034.1">
        <property type="nucleotide sequence ID" value="XM_003021988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Q8"/>
    <dbReference type="GeneID" id="9578918"/>
    <dbReference type="KEGG" id="tve:TRV_03851"/>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="68"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="387" mass="43662" checksum="2455061E996CF1F3" modified="2010-05-18" version="1">MLDPIPPPPRWLQDLVTPIAQRWSLPTLPYHIHEVILSFALYQFIQSIVAPRISTWLFPKLYPNFSKRTKLGWDIHVVSLTQSTLISVLALWVILVDEERKNMTPVERVYGYSGACGLIQAMATGYFLWDLIISVRHVNVFGVGMLFHAISAVLVFSLGYRPFVNYYAPTFILYELSTPFLNFHWFFDKLNMTGSRAQWYNGMALLSVFFSCRLIWGSWNSFTVFSDIYKAFHISDSSVPLSSPEFYSLVFSARNSTICLDDNCIKANAEVSKFTDFSAAGIPLWLALTYLGSNTVLNSLNWYWFSKMIDAVLKRFRGEDLPSPDKVAPPESIEGDANPIILEAASTLEKEEETLITGALDAESKASNNTTQSIPMNGGSGARRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Z6</accession>
    <name>D4D9Z6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021953.1">
        <property type="nucleotide sequence ID" value="XM_003021907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Z6"/>
    <dbReference type="GeneID" id="9578837"/>
    <dbReference type="KEGG" id="tve:TRV_03940"/>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="601" mass="68675" checksum="A50EB5B9BDA64EC7" modified="2010-05-18" version="1">MMRATRPKKLTPKQPIPIFREDQIDLTEDDPQTTLQSIETGVEKAEETEFHLQAAINATAFGNAAQTHIPTPETVQSSVQYDTLYRPVFSQPATYIRFSSTVEDCSGCGYNLVEEDDVALKIMNQKRDASTQCTEDQFEEVMSFFEETAQAKQPFAAVDNPPVVSYPEMEECFDGMIHEKLRPFVREIYESWKLRRTASGNRPLQPTLKVSRPAQACRQTFADIFLQFETGQDTDDGDPYVCFRRREVRLARKTRGRDAQSAEKLRRLRKELEDARTLIAMVQQRELGRKEVFAAERQLFMQRCEVKEMKRKLGIKDDDEDLINQKVKPTTDVLGFCFSITDSDVQPKKKPTEVPVIQRPNVPQLRVPSRSTGQLGEDLQLLEDVQADKENDILREIKQNVAKHAKWNEGYVDITRAPLTPTTPQGFEAEFRPAITHEYLPTPPTSETSERMRDIHSGPSLETQWSALRQPSPSEDDSCRPTPSFRRRVGRGGRVLIDRRNLALRNKDGVDPIKLDRFKYDRDDDDMDIVYEKDEFDIQIMQHRAYLSAKARDQAITQAQLQAQQQAHSQQVPNGRRLPGAPPTPGHNNVNPNSSNIAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA79</accession>
    <name>D4DA79_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021848.1">
        <property type="nucleotide sequence ID" value="XM_003021802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA79"/>
    <dbReference type="GeneID" id="9578730"/>
    <dbReference type="KEGG" id="tve:TRV_04025"/>
    <dbReference type="HOGENOM" id="CLU_060131_4_0_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="247" mass="28921" checksum="3CD6968337BA52EB" modified="2010-05-18" version="1">MRLELQLVGEDDFLELVTALWEAYEEPHQKFFRIFCPIFNNDREKSLADSIKFFQEEYRNEFPVAQWVKVVDADANNKIAGAALWKIHQKNPYETYDEGKVVADWYPEGSMERIIANKYLRDTTAPRAKKARRPHVFLNIAFTIPSYRKHGVSSLFLKWGLDKAEELNFECWLDATPYGRPVYERRGFIVTDAWSVDCPMPEGLSEEKQKEFQGARERLLPVDNACMWRPRGGVYIEGVTKKPWETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA92</accession>
    <name>D4DA92_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021861.1">
        <property type="nucleotide sequence ID" value="XM_003021815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA92"/>
    <dbReference type="GeneID" id="9578743"/>
    <dbReference type="KEGG" id="tve:TRV_04038"/>
    <dbReference type="HOGENOM" id="CLU_2211885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="107" mass="11530" checksum="1FD9A844E2CB1117" modified="2010-05-18" version="1">MPSIEPIQIQPLPIFNGKENGLSSLKSPTKNGDVFVNTFDIPLPPPAKKPLEILGIDKDTPDGHVPRDPIQIRLTGVHPLNSESPLTALFDEGTIPLVCAATGNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAD7</accession>
    <name>D4DAD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_04084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021753.1">
        <property type="nucleotide sequence ID" value="XM_003021707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAD7"/>
    <dbReference type="GeneID" id="9578633"/>
    <dbReference type="KEGG" id="tve:TRV_04084"/>
    <dbReference type="HOGENOM" id="CLU_002976_4_5_1"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="17">
        <location>
            <begin position="313"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE41135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="531" mass="56955" checksum="BD2ADE3AD5DEB33F" modified="2010-05-18" version="1">MNVTGAWLEGVTGKGTVTAVIDDGLDFHSTDLKKNYFPDGSYNFVENSKEPDPKLVNQTHGTRCAGEIAAGINGICGLGMAYDGKIAGIRLLSGQIDESDEATAINYRYQLNDIYSCSWGPPDNGRVIGGPGTLVKRALENGVTNGRQGKGSIFVVSAGNGGYLDDDCNFDGYANSIYTIAVGAIDREGNHPEYSEPCSALSVVAYASAGYQSDGADSIYTTDVGVENCASGHGGTSAAAPLVAGAIAFALSVRSELTWRDIQYLLYTTAVAVNEEEDDWQMTKLGKPFSHNYGYGKVDSYSLVQMARNWKLVKPQASYHSPWVKVNKNIPQGKKGLSSIFEVKPPTVSAFERLEHVTVTTHVNHTRRGDLSIELHSPEGVVSRLSTTRRNDNETSGYAGWAFMSVAHWGETGIGNWTIVVKDTIINDFSGTFLSWQLNLWGEGTDSLSSSSSDKTDEVNNNETPMQTPDTEDVGVSWDLLVASTGLQRLSGWASLSVSVSVVVCGAVGTYLLFCKLSGRHAAPIIADTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAH6</accession>
    <name>D4DAH6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021792.1">
        <property type="nucleotide sequence ID" value="XM_003021746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAH6"/>
    <dbReference type="GeneID" id="9578672"/>
    <dbReference type="KEGG" id="tve:TRV_04123"/>
    <dbReference type="HOGENOM" id="CLU_012062_29_0_1"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="46567" checksum="0556FB4F1F5D6BEA" modified="2010-05-18" version="1">MSLPPPPGLQRPPPSQAASQAQPPASLPARPPSTASSYTAPPTSSTTPSTVSRPPSHGSDVSRPAVGAAFGFQPRAVAAQSYRAPQAPTYSTVYNAGYQYPQPQHQHQPPQHHHHQQQQQQQQQQQQQQTYQAQPTSYYGQSQPQRPYNASTYGQHNTYQKRNNTNSYGARSGQSRYNESSGDPEMDAQIAQWQSAYMSKDSSEAAAGTAAASGPAATGANGGPMGSFQRLHDPLSSTSTPPNGTGSGTAASTTPIPGANQGLAAVPGQESTEPAKTVVRSGGGQTWTDSTLLEWDPAHFRLFCGNLAGEVTDDSLLKAFSKYPSVQKARVIRDKRTEKSKGYGFVSFSDGDDYFKAAREMQGKYIGSHPVLLRRAMTEIRPVSANKGKHLKGKGKHGHHSGSGYSKPSATPAPVSSSAGKTDGGVKKQKTKGGLRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN7</accession>
    <name>D4DAN7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021674.1">
        <property type="nucleotide sequence ID" value="XM_003021628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN7"/>
    <dbReference type="GeneID" id="9576757"/>
    <dbReference type="KEGG" id="tve:TRV_04185"/>
    <dbReference type="HOGENOM" id="CLU_021458_9_0_1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF158">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G08970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="346" mass="38803" checksum="2130816851533753" modified="2010-05-18" version="1">MGKYRLKDRLWELNCGILGLVLAQGAAFVITGALKNACGKPRPDLIDRCKPRTFEQPEFGLSNYTICTQTDHEILKDGFRSFPSGAYNYQSLWIEEGPFLLRTNFSFLVLGHSSSSFAGLFYLSLYLAGKLHVMDSRGEVWKAFIVMVPTLSAGLVAVSRIMDARHHPFDVISGSLLGVGCGWVAYRQYFPSLAEPWKKGRAHPIRTWGSIPEPPVYTHRRLLEYENDQMKLVPRADEEYQAAQASQEQAQGHEVPESAPALMSNPFEHQKAQRRRRLADTDYGASSSESEGYEMQQTRYEPRHHQGVADTSSDAAPRYAAYHPPDNRASSNSPPLERHPASIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAR2</accession>
    <name>D4DAR2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021699.1">
        <property type="nucleotide sequence ID" value="XM_003021653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAR2"/>
    <dbReference type="GeneID" id="9576782"/>
    <dbReference type="KEGG" id="tve:TRV_04210"/>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="103"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="41144" checksum="8510BEDAF0DDBC88" modified="2010-05-18" version="1">MASAARTFSRALARGATPVTSVRPSATRNAARFSLPAQTYRASWRRGYSTASEPQKSSSGMYWALGAVALAAGGTYYYMNNESFAAAQKPFVPTKEDYQKVYDEIAHLLVEKDDYDDGSYGPVLVRLAWHASGTYCKDTKTGGSNGATMRFDPESNHGANAGLKTARDFLEPVKAKFPWISYSDLWTLAGACAIQELQGPTIPWRPGRKDNDASACTPDGRLPDASKDQKHIRDIFGRMGFDDREMVALCGAHALGRAHADRSGYDGPWDFSPTVMTNEFFKLLLSEKWVNKKWSGPAQLTDNKTKTLMMLPTDMALIKDREFKKHVERYAKDSDVFFKEFSEAFVKLLELGVPFESKPEDRFVFKPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAX0</accession>
    <name>D4DAX0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021595.1">
        <property type="nucleotide sequence ID" value="XM_003021549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAX0"/>
    <dbReference type="GeneID" id="9578582"/>
    <dbReference type="KEGG" id="tve:TRV_04268"/>
    <dbReference type="HOGENOM" id="CLU_1860110_0_0_1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="138" mass="15534" checksum="C8CE9CE09FF77868" modified="2010-05-18" version="1" fragment="single">QYAAVDIIYILTSFFIKISILLLLNQLFHVIRQLRLLIYIGIVVISIVTIPYLTISSIRVSRCNGIKALGIMICSNKVVSTTNLVFGLWNVLSDFYILAIPISQIQGLKMPNKRKIGVLTLFLTGFMYELPRSLITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB71</accession>
    <name>D4DB71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021523.1">
        <property type="nucleotide sequence ID" value="XM_003021477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB71"/>
    <dbReference type="GeneID" id="9578484"/>
    <dbReference type="KEGG" id="tve:TRV_04370"/>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000113">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="571"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="651"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="712"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="788" mass="86483" checksum="C10D1B56309CA2C6" modified="2010-05-18" version="1">MHGVKLKSSPRKVSPPGPTFMNDEELGNYLRDLRTARPPRPNGSRPLPSKASGPAASLSLKDTPARPASSFSTRPSDNVHSRSSSKDIIPRSSSALSHRRTTSEVSTPTSSSSGTPTIPECEVFNGSRNVSHCGSSLSSATSTAIPYIERGQRWMERQEVRSLRSALEEMDVQDDESRLFEAAQEEATELVLEHQTHGFKQKDTHSAYRNPDLKTVSRLRQHLEKGSHARTSSIGRGGDTPRSQSITDSIRSSSESSNGSPPTSDKTSDGIARPLRRVNFALPKAAADKTKEDNQSRRRSVSGGSSKGIFRNPEDSIYEEPEENSTQEEPTTAQNTAPTSALTTKPHNSVLRGARPFPNRWSGSSTGGKLNRFDIHKNPPSQTRNPLYTTNTCTPREQTPDPENKQSTPTKNGIEIRDDEIRAATSMKLKDRSTKLPMPSAVSDRPGRPIVNFDPNWKEPEQDEPVGPPGSGHDASTQSTSSSVTPAPVPIPEVNVSAPTVPSISIENEGPTGPEIRISPLGPTISEMEQTSQVQQKRELPNPGHRQSNNRPGSRGIERYQSLSKAGIPTASCVVCGLSISGRVVTASSYRLHPECFNCFHCRTPLECVAFYPEPEEKRRERLSQPDLHQDLGPDEPRFYCHLDFHELFSPRCKSCKTPIEGEVIVACGSTWHAGHFFCAECGDPFTPTTPFIEKEGFAWCVRCHSRRTASKCKACKKPVLDDVVVSALGGQWHDECFRCDECKGSFGPDGRFFVRQGKPKVNARGRQIGGPVELPICEPCESRRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB99</accession>
    <name>D4DB99_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear membrane fusion protein Kar5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021551.1">
        <property type="nucleotide sequence ID" value="XM_003021505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB99"/>
    <dbReference type="GeneID" id="9578512"/>
    <dbReference type="KEGG" id="tve:TRV_04398"/>
    <dbReference type="HOGENOM" id="CLU_033545_1_0_1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="65699" checksum="71368123DE68F3D0" modified="2010-05-18" version="1">MAYSASYPRVVRIISLFFYLHILTSTIGSVTGFKLPSFLNSQAPAGLRFRDIDKVPDDDSQISIDLPLLLHKNPAQGNIFFSKALHLLDSMQHAPSCNQRAVASLITSCQALSPETSERRHYTHFNLDHVKSLYAARLAVCEITGTGAAIPEKCLDTFPSHNSWRPQYKDSSQGFQVADEERSIPAAVLEPCLRSLESKPQWWTSYSNGRQNAAVMCHAARFEIEKEELLNHHRSLTEVTHGLNMHLNRSLEDSYTQAQQHREFIRSIDTLRQNLLRDLRRDNNNIQNQVTELLSGTRDMFRNANGEFRGFIETTLTETATLAKQIKSSIISAQEVKRVLNEVLVKEVKRNSDLVSAEQTALQANARLITNIQGSLTEVKQAGMGIIVEELKHLHMSMRVNHIDAALSHFEEKAAFLQNVMTTQILNQTRLQQSFHEDLRAAQTLLHNITNSAIYLQATIGDAQSTFSTLIPWKGSLISIIWWLWYATLFGILTLFKTKLIIYAIFFSVFGAVLFILGCHDWFQTIQTPTLITLRQVTPVEIICFALVFVISSLTIVTIAVKGFPFKSKLGMNTNSETLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBB4</accession>
    <name>D4DBB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04413</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000221">
        <property type="protein sequence ID" value="EFE40854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021472.1">
        <property type="nucleotide sequence ID" value="XM_003021426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBB4"/>
    <dbReference type="GeneID" id="9578433"/>
    <dbReference type="KEGG" id="tve:TRV_04413"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="179"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE40854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="523" mass="55468" checksum="A1C911F4B6D64785" modified="2010-05-18" version="1">MAVTGVEPAMAGNRIKTESPDAGIAGGRGARQPANPLLVKSKDGCLSSKFDVFVSGGENEMPILFRMEASSRMPIYVAAAFATGAICTIAIDRLLRSEGVISRTEPGSKDAMNGLSTANGIEYHGLPKKPQPPPIVDGIEGCIGNTPMVRIRSLSEATGCEILAKAEAEANGLLTPFVGDAIYEGTVGSTGISLATLARARGYLAHMYGINDHTFSLVNCMPSDQSTEKSNLLLKLGAVVDRVTPAPIVETGHFVNRARSLAHSHGKAAQTSRDSSPFEKPNIEAMTSDAAAKQSRGFFADQFENSANWQAHYRTTGPEIYVQCEGKLDAFVAGAGTGGTISGVARYLKPRVSNMTVVLADPQGSGLYNRVRYGVMFDTKEREGTRRRQQVDSIVEGIGINRVTANFEAGRELVDDAVRVTDAQAVAMARWLVEKDGIFIGSSSAVNCRTFLAIIHTLTGGINSFICTGFAAVKTALKLGPGHRIVTILCDSGTRHLSKFWAEAGNVGGAIGTKLEDVLNAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBT9</accession>
    <name>D4DBT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021277.1">
        <property type="nucleotide sequence ID" value="XM_003021231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBT9"/>
    <dbReference type="GeneID" id="9578122"/>
    <dbReference type="KEGG" id="tve:TRV_04590"/>
    <dbReference type="HOGENOM" id="CLU_040954_0_0_1"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="457" mass="50555" checksum="CC62A5AA3A12910E" modified="2010-05-18" version="1">MAETDRATSTPKKATGLNPESPTTARPLDFDDEPQETGLTSANTTSRSSSQLNLAANMQNQSQSQGQPRAPNPYQRIIDDLKEAFPNIDAPVIKAVVVASDGNVERAFNALLVVRAGMSDPDAQEEVRPAVPPRPSAGGVATSTTQSQLEDDERYARQLAEHYSGADQRRGYQQQPSSSIWDHGPASGQRGQGLKPNELYDKEHSFLDGAYDFFFRKIIILLMLMLMDIGIDDLPIIKENIRKGFLETQSRVNSWVENFKRRLDGEESDEDAQYGHSQRQYGQRQQQQHQQQYGYPNRRSVDRERYDADPHVLGDDFSSLELRDNEVPPPRPPRPQANPDLFKSKSASASPDRRKVSFQEGPPEEIQDSFSANTSSNIINNNNNSTSGTANNNANTSAGSRSTANKSSKWQPLSTVEPSPVADNDPFSLGDSDDERESKAKEVKGEDAAKKAEKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC28</accession>
    <name>D4DC28_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021248.1">
        <property type="nucleotide sequence ID" value="XM_003021202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC28"/>
    <dbReference type="GeneID" id="9578093"/>
    <dbReference type="KEGG" id="tve:TRV_04680"/>
    <dbReference type="HOGENOM" id="CLU_540903_0_0_1"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="462"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="562" mass="62194" checksum="23513F941C191A97" modified="2010-05-18" version="1">MAQNELKRPDQQFSISKSISALIQVSQHLNLYHIYLFEQILLCCKDIYPAKQKSKLMGKEKIIPNPKVKPKLQLKGRIYMTNVTEILSLSKPGSYKIQIFWKGDPGVVDNFGIRYRDEDTMNKWYKDIDKQRALQTHERPSSKSHGTSETEFTYLRNTPKPPNPYQEEYSTEEELSREPTNTSLSEFSTSRNASNTSLRGRSATNGSGGSGHHSGGRPQFPTPNAPLTVHTQFTPGAISPGERNGASYFSPTGEAPPSTRSSSQSTAFSYSRGGTPSNAWTEAEQNRYTAPAMPRSGSRDGSGNNPYYNNGSRNAQRPSLPPFSSNQNGQSGSQSQAQARMRSASSPDIHNGAAPDSRRYMNGGHTMQTVDNVPVPPIPPHMANMRAPVNRSQNSSPTGNTIPIRSGTQSPNLQPPPSRHGHAHPPPVGYNYEPHAPNGRPLQPPTSMPHTSPFDDPDSQMPSQLKAKINFDDNYVTLVIASNILFRSLTDRVDAKLARFTDRSIGGNSARLRYRDEDGDFVTIDSDEAVQLAFMEWREQHQHSLASGQVGEIQLFCQPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC61</accession>
    <name>D4DC61_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021196.1">
        <property type="nucleotide sequence ID" value="XM_003021150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC61"/>
    <dbReference type="GeneID" id="9578040"/>
    <dbReference type="KEGG" id="tve:TRV_04713"/>
    <dbReference type="HOGENOM" id="CLU_2456386_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="89" mass="9726" checksum="A2547EF89205FFF7" modified="2010-05-18" version="1">MKQRERQGKYGSSSSSSSRAWSVRQQGGSAEKWTPSGHLLFFLDVEDGLGDVVRGMPAETNIKEPSPATAQKDMMDTYLGNQYQQAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC96</accession>
    <name>D4DC96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maleylacetoacetate isomerase MaiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021134.1">
        <property type="nucleotide sequence ID" value="XM_003021088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC96"/>
    <dbReference type="GeneID" id="9577977"/>
    <dbReference type="KEGG" id="tve:TRV_04749"/>
    <dbReference type="HOGENOM" id="CLU_011226_20_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25628" checksum="7FB339F22B1EA094" modified="2010-05-18" version="1">MSSSNVKFQLYTYFRSSCAGRLRIALNLKSTPYEPIFVNLLKGEQLSDEHKEINPNATVPVLLSTHQENGKSTTFKVTQSLAALEYLEESLPNTRALLPPVSNPEARAQARELALLIATDIQPVTNLRAQKKVKQLDADATKWALEFSVAGFTAFEKTVVHSAGKFCVGDEITLADVCLVPAVWSAERVGLKLADYPTTKRIYDLMLEEAAVKEAFWQNQPDTPEELRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCC2</accession>
    <name>D4DCC2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021102.1">
        <property type="nucleotide sequence ID" value="XM_003021056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577944"/>
    <dbReference type="KEGG" id="tve:TRV_04775"/>
    <dbReference type="HOGENOM" id="CLU_002087_0_0_1"/>
    <dbReference type="OrthoDB" id="4169865at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="390"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="536"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1510" mass="165205" checksum="D02862E76901855C" modified="2010-05-18" version="1">MPPLILSIITGFHYHNEVKPVLPLSEHDPSPIGDPTTYYPDQHDCPLPCVDYANIHSWIPYFSVDRLRRCQEPLLVQLSVTQPLDDLESTILLRTCTSSSNISHAFAAKQINNPKKSEELYQRRLDTVPACVTTGTEVQDRLNLAIGASNERKITHATRLLDGMEKFFSAKDNCDENFLFAYYNGTAVGLYIGPGLGKPTAKSALSALSSYIRTRGAVSNTAVQLCGDDRKSDRVFGIYIDTTGDLTAVQKTVSEWSKGNCMTGLKSLGDLADVKVMDIAGMRITSGNDTTNNGTHDSTHSHPRLLKIRHNLLHTNFLGKRDVCRYIQIMPGDSCTSLSMRCGIRGADFLKFNPKQDLCATLQPNNYICCSAGDPYTPPTPKPDPDGTCASHIVQNGDSCDAIARKYRVTVADLENWNKAKTWAWTECKDILVGYKICISDGSAPMPAPQEGAECGPLVPGTQKPTNKSISLADLNPCPLKSCCSNWGYCGVFPGHCTINAPEGGGPGSKKKGYENTCVSNCGNEIKQNSGPPASFQRIGYYEAYNLKRDCLKLKAKDANTDGSYTHMHWGFAEIDPNTFKPIIKESKEQWEEFKALPNVKRIVSFGGWAYSTDAATYNILRSAIITNRDTFASNLAQFAEDEGIDGIDIDWEYPGAPDITVGGKPIGEKRDGLSYLRFITVLKQKMGPDKSVSIAAPASFWYLKAFPIDTIARAIDYIVYMTYDLHGQWDYGNANAFDMCPSGKCIRSHVTKAGVPNNKIFVGESSYGRSFHMAQDGCWGPLCEFTGSRTQSDAQPGRCTKTAGYISFAEINEIIKRGDGVNVFHDDASNTDVMLYKVLTHFGYIRGDYISYMTPVTKDTRRADWKDLNFAGSIDWAVDLQSFTSTDYESTPERASSGMGCIRGGDKTLDTGSLCEYSCYLGFCPESLCTCLEMGPLRNLPKEHSGVNVVAEDENDVEMTRLCIFSCKYGFCPGDICITPVDWSNDGPEMVGDNPDAFNTSDARWQNSHRCFVYKDAPYDHIGLEQCSRACKPEIDAAKEAGRMYNVGCLGFWPLEKEVPWVRDPSSMHEVADGMCLCDSVFLNELATTFLEALPAIGQIGCYILLSTIKLVIDIGTAIIPPAGRAISAGLDAVMTAAQLASYVYSETEDPAGAFEWWLSPCGGSDLVPDDLKKAFDILSGVAEGISSFRKPKNIGRGSGKKGDEGNPRTPTQPRPKAPTKPKPTGPKKKRCYIPPSKETVRLGRAKNTIRVQSCVSSRTVRQELIITSISYGPTPTATTADCAKSLSQACFHYSSAIRVNPHWATLTCPPEAAVTANDRKEGSAVAAWSSQHSGAGWQDGANRAQTKCQRDEYPPAYFLGPNDPARTNSGLNAQGQLIRWLPGRENGGGGQIWSGACFIGPVKALSDQEFRRKVERASGVNRRVLRAGDLTQTMALVDVPTRPEFSFTSWGHSANPPCRDGLEANPCWPSGIAALDPGFTLLTFDPFYNGQSPPYDYKAPYVKGSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCH2</accession>
    <name>D4DCH2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021075.1">
        <property type="nucleotide sequence ID" value="XM_003021029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCH2"/>
    <dbReference type="GeneID" id="9576722"/>
    <dbReference type="KEGG" id="tve:TRV_04827"/>
    <dbReference type="HOGENOM" id="CLU_1442053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="188" mass="22460" checksum="49DE34E50BDB2BB1" modified="2010-05-18" version="1">MRRTVRPLGSSTGFALSLVGGPVGGRLSSVRDRLGAKRKREEERGREKREEKREPEMKEKKRRRSWTRAKEEEEEEEERREREREGRKKVERAKKRRQKKKKRRRKKKKRGRQARKGKGEGVKTLRDGRKGKEEGEKRARRGREDGCRRRAIRGGYDSDTLMIHDDTRRYSDTDDTDATEEEKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCR2</accession>
    <name>D4DCR2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04917</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021052.1">
        <property type="nucleotide sequence ID" value="XM_003021006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCR2"/>
    <dbReference type="GeneID" id="9576699"/>
    <dbReference type="KEGG" id="tve:TRV_04917"/>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="228"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="426" mass="46937" checksum="52966C11BB0509C0" modified="2010-05-18" version="1">MITLDLGSLCAECVSVIKDIPLSLLFGLLLSCCMGLFSLVYLLLLILAPAPRAPFPEEKKYKAILEDGSLSKDQQLPCWHDKINLDTYKQSDLEEPTLFMSVVIPAYNEEKRLPGMLEETVSYLQRAYGTPERTGQAEKTKTTSLQDGDLGETRLRHHANGKTRSTTDKDSGVPLKGWEILIVSDGSTDNTVETALAFAKDHQLSTHPKGHAGPWTPKIKEGVKIPAGSIRVIELTQNRGKGGAVIHGMRHVRGQYAIFADADGASNFNDLGKLVEACEKMEDPNRRVVAVGSRAHLVGSDVVVKLTFLKRSKLRNFLMHSFHLALRLLTPPATARINDTQCGFKLFSRASLPYIIPYMHSEGWIFDVEMLMLAEFANIPVAEVPIGWKEVSGSKLSVVWDSLGMAYGLAILRAAWGFGVYTRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDL1</accession>
    <name>D4DDL1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020696.1">
        <property type="nucleotide sequence ID" value="XM_003020650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDL1"/>
    <dbReference type="GeneID" id="9577395"/>
    <dbReference type="KEGG" id="tve:TRV_05222"/>
    <dbReference type="HOGENOM" id="CLU_045003_0_0_1"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005126458" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="131"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="396" mass="44465" checksum="9A5D0A3CE7F8917E" modified="2010-05-18" version="1">MTMAVSERPALALLTMLLYLPFLGLLFSPVNCYTPVSDTTLRSLPRPGSDFDIHNGAILAPILRPRVPGTPGSIAVLEHFVKFFKENLPDWRLEFQNSTSKTPVTGDKQIPFINLIAIRDPPFAKVGDVSRLTLAAHYDSKFTPEGFIGAIDSAAPCAMLLHAVRSIDAALTKKWKAMQLSPTDNLDIDAHQGIQIFLLDGEEAFGEWTATDSLYGARSLAEHMEHDYYPALSTFKTSLSAIRLFVLFDLLGSKDPIMPSFFATTHWAYKHLAQLEQRLRTLGLFKSDPDPKKGAPKAWFTEGNRPSDRKFLSFISDDHIPFMQRGVEILHLIPWPFPRGIWHTMADNADNLDPPTVEDWSTLITAFAAEWMDLEGFFDTKKSKQTRLDVEDKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDN6</accession>
    <name>D4DDN6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_05247</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020649.1">
        <property type="nucleotide sequence ID" value="XM_003020603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDN6"/>
    <dbReference type="GeneID" id="9577342"/>
    <dbReference type="KEGG" id="tve:TRV_05247"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="15">
        <location>
            <begin position="97"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="14">
        <location>
            <begin position="392"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="17">
        <location>
            <begin position="728"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="16">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE40031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="966" mass="109724" checksum="2F14FEFC4C181979" modified="2010-05-18" version="1">MAPSRASHPRWSFILVIVTIVSFLAVPAVMVKHENFKTCSQSGFCQRNRQYADNAAAQASAWTSPFHLEAGSLTFSDGQLLGTVIKTVGNDEKVRFPLVVSFLESGVARITIDEERRMKGDIKLRRDSTVRKERYNEAAKWAITGDMKRSSSAEFTTDETSGTTKVQYGPDMKFEAVIRHSPFEVYFQRDGQTQVQLNSKGLLNIEEWRPRNDVIEPGSESTPDVLDDSTWWDESFGGNTDSKPRGPESVALDISFPGYEHVFGIPEHADSMSLKQTRGGEGQHTEPYRMYNSDVFEYELNSPMTLYGSIPFMQAHRKDSTVGVFWLNAAETWVDIVKSTLLPNPMSIGVDAKTTTETHWFSESGQLDVFVFLGPTPDTISKTYGELTGFTQLPQQFAIAYHQCRWNYVTDEDVKDVDRKFDMYQIPYDVIWLDIEYTDGKKYFTWDPHTFPDPLSMQKQLDASERKLVYIIDPHIKVEANYPIVDEMKKKELAVLNKDGDIYEGWCWPGSSHWVDCFKPAAMEWWANLFKYENFKGTASNSWLWNDMNEPSVFNGPETTMPKDNIHHDRWEHRDVHNVNGLTFVNATYNALIERKKGEIRRPFVLTRSFYAGSQRMGAMWTGDNQAEWSHLAASIPMVLNNGIAGFPFAGADVGGFFGNPSKELLTRWYQAGAFYPFFRAHAHIDTRRREPYMVGEPYRDIITQALKVRYQLLPAWYTEFQRASVNGSPILRPQYYVHPSDEQGFALDDQFYLGHTGLLVKPVVTQGSTSVDVYIADEEKYYDYFDFTIYQGANKKHTINAPLEKIPILMQGGHIVPRKDRPRRSSGLMKYDPYTLIVVLDSKGQAEGELYVDDGETFDYKQGAYIHRQFSFSGSSLSSKDQSTSGSKTNQYLKVMAEVHVEKIVIVGAPSSWKGKDSVLVLEDGAKSGIKVSMNWYDAESGKAAFAIVKKPGVSIAKSWKIDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE22</accession>
    <name>D4DE22_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020492.1">
        <property type="nucleotide sequence ID" value="XM_003020446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE22"/>
    <dbReference type="GeneID" id="9584231"/>
    <dbReference type="KEGG" id="tve:TRV_05386"/>
    <dbReference type="HOGENOM" id="CLU_042070_0_0_1"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="457" mass="49650" checksum="BE1F03EEB63516DE" modified="2010-05-18" version="1">MAYTDDAVKAKLSALNETQESIVTVAQWVMFHRRHADRTAQLWLEKLRDANPPKRLNLIYLANEVAQQSKGRRKEDFLIAFSPIIADATATAFKGASNEIQQKLRRVVEVWRQRSIFEKPIQDAVEARVEGVYLLYNALHIFPSVQCELILEILEIDKSKPAGKKPLLGGSLFSNSPGSLPQELQPLAPLQIATSKASVSSNATVTTANTEYDNLNGPSAEIPTPPVYAARLSTLLKTLANAESSVSEVIKCRQSLIEGLEKVLDTNRAALVKEKSQVEQLSSRRTETENKKRDVEDAIIRGLTADDPSAQQSNGGAAWSDHKNSFGGEEPEAPAVEALTPPPVEALTPVQSPTLNPSSNNKNEQQSSTIPSHTKAPSPGNFGDQAQMASIDLNATLSSLQAATNTPPNDTSASELATKKRKVSHAQDSYPEFEGGDAMADLDADVAELLRQESSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DED4</accession>
    <name>D4DED4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020383.1">
        <property type="nucleotide sequence ID" value="XM_003020337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DED4"/>
    <dbReference type="GeneID" id="9584142"/>
    <dbReference type="KEGG" id="tve:TRV_05501"/>
    <dbReference type="HOGENOM" id="CLU_056019_0_0_1"/>
    <dbReference type="OrthoDB" id="5339271at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30280" checksum="0FF77880A2B861D9" modified="2010-05-18" version="1">MSIQPDIYTTPAPAATMAQEGSSYYDSPYMVEFYNLKWGKPSMPGMGIYWKIFTDAVTQHREAAPDKPFSVLDVGTGAGRVPIGNALALDELPTLLPLSDKHITIDLLVFAFNSVYHMERDGEFAQFFLQVSKVLTPGTGRACIGLADWFLLNPGEDMKARAESEELPPLEDVQSVDFPGLRYHTTMNRMDCQGKLCVCGEDVQVFQQLDDGRDKEIEVHRVRHSLRWFTKPEFSTAIEAAGLRIVEVSKVDESEETVGYDDNVYNLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEF3</accession>
    <name>D4DEF3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020402.1">
        <property type="nucleotide sequence ID" value="XM_003020356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEF3"/>
    <dbReference type="GeneID" id="9584128"/>
    <dbReference type="KEGG" id="tve:TRV_05520"/>
    <dbReference type="HOGENOM" id="CLU_020266_0_0_1"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="595" mass="68641" checksum="5CFB35062D06B7A9" modified="2010-05-18" version="1">MPGILLSQFPDEILHSILTYTPPSAAIALEQTSKRFSHITNAPLLWAGYCKASFRFWDKRHDITDKFARPAKSVQWKELYKLRHQIDRATTEILDSILASQTGRIEKIHRIVSFGYDAKDTLIRHADAPQDLEDYLARRYYSNAILGCLHRTLAIPTWNRLRNGEDVSLEHALGAFDMFILDSGTGDFDDISRSLDNIVGRMKRQYPNILEYTPRERAIMTAEYLRENNLTGIESGREFYNIEHNFLGAALTSERHNSLPLISAAIYCYVAQRLGLDAHPCGFPFHVHVIIRPEPNHDLAGNRLPDGEEGDFMYMDPFRSTSETPVSELQSQLNFLGALTLSQSTFLRESFTAEIVLRCGKNILNSVLQTPHFRQTSLDIVNVKYAALWASMLFAKYANPDRQNIPQGPERRRAEHLPLRRHLPSLMEHFATDFPADVYLIEQYLIPLFQSLPEYEHLRESVSVMKASDEIPKQVRRRSSANGNVKYKVGQLFRHKRYEYIGLITGWDPECGAGEQWMERMGVDRLHAGRHQSFYHVLVEDKSVRYVAEENIEICELEASEVPDAFFSFAGKFFKRWDIETRRFVSNIRDEYPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEQ5</accession>
    <name>D4DEQ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000305">
        <property type="protein sequence ID" value="EFE39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020290.1">
        <property type="nucleotide sequence ID" value="XM_003020244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEQ5"/>
    <dbReference type="GeneID" id="9584029"/>
    <dbReference type="KEGG" id="tve:TRV_05644"/>
    <dbReference type="HOGENOM" id="CLU_1107777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="27372" checksum="7D327DE6969A84FF" modified="2010-05-18" version="1">MSASSLNLARTRSTSAGRDGLPSARPARPPLQNRTYSAPVGKLHLQAGRSGKQDAAGFTAIAENEATMTGQEPEDKEKEKDSSEEAATSGHQLPQVNLAVVGAAGVGKSTFVKCALDLKQTPLVRSSIKKMSMDGAIYVVRLLEIAIHKITLDDRGRIVWPKCLGEQALSPIDGVLCLFDSTDLRSVSQYPQVLGKTQPLPRCRCRCRCRSRLFVSFLFFSFLPFFASFVLPGFRRVISAAGTTAERTEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF18</accession>
    <name>D4DF18_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000323">
        <property type="protein sequence ID" value="EFE39555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020173.1">
        <property type="nucleotide sequence ID" value="XM_003020127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF18"/>
    <dbReference type="GeneID" id="9583944"/>
    <dbReference type="KEGG" id="tve:TRV_05760"/>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000868">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="583" mass="63441" checksum="EAA4A2BA0B7E828E" modified="2010-05-18" version="1">MEGFDEEEFKKFFPSGFGKQTKEADIKTQIDRTKRKEPIETPGARTAEKPASPSQEAADDKDGGDSDSDSDSDSPEDEFPVSHNLVFKTHDRAVTTITLDTAGARMITGSTDCTVKFHDFASLTPSTLRAFKSVEPNSRKNATSSSEIHPVHIAKFNPISPSQFLVVSATPQAKILSRDGDTIAEFVKGDMYLRDMKNTKGHISEVTSGTWSPTDYNLCVTAGTDSTLRIWDVNDPRSQKEVIVHRSKVAGSAGRSRMTAVAWASPTQGGPNALIASALDGSLVMWGGDGPFTRPSAEIKDAHTKDSWISGLDISPDGRLVVTKGGDDLIKLWDTRKFKQPITTVSHVSGSKFHPTSNIQFSPTGANIVTGSETGHLHILNPATLKPELVTLVTPDSPLISVLWHEKLNQIVTGSANAETHLLYNPSLSHNGALTIMSKAPKRRHVDDDPNFTTDISLGFSGEGIVNGSGIAAASLAARHPNVGLTASGRSRDPRRPHVPAQTPFAKSQPDEKHIQDNIPLSSMRDEDPREALLKYAEAAEKNPIFTYAWKDTQPKTIYAELSDDEEETKGKGPDKKRIKRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF72</accession>
    <name>D4DF72_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="2">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000335">
        <property type="protein sequence ID" value="EFE39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020123.1">
        <property type="nucleotide sequence ID" value="XM_003020077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF72"/>
    <dbReference type="GeneID" id="9583884"/>
    <dbReference type="KEGG" id="tve:TRV_05817"/>
    <dbReference type="HOGENOM" id="CLU_023588_0_0_1"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="4">
        <location>
            <begin position="97"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="48068" checksum="3453EB6C934B96AA" modified="2010-05-18" version="1">MHNARSQNPDRRPRKKAVNPSVQRAVKLFIDNHLEPSFMLDNHIDLDSLLSSVSKRFTIYEPLLLLSPNFFNKSPQWESFISLLTDAQLQELYACIVEVFSPMGVTHVAVNAPISLTTRIGKENKVRGPTDLTPLYGDFGPMIPSTDQNIDPSETDLQQAFWVKTVQNSKITQVWAPLYTMFSRGNIVEKARILGLESRFDGLNEQQLCQPVQKISVIDLYAGIGYFVFSYLKMGVARVWAWELNGWSIEGLRRGCEANKWGIKILKMNNEGTVDGIDGLVEMLEDDNLRVVAFHGDNTFAAGVMQGIKAKMEARSAWKPIRHANLGLLPSSKETWGTAASLIDPEVGGWVHVHENVNVHEIQQKQAAIVAEFERIQSKKKLIDGHASSEVECVHVEEVKTYAPGVMHCVFDLNIKPSRIFDRENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFK3</accession>
    <name>D4DFK3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019985.1">
        <property type="nucleotide sequence ID" value="XM_003019939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFK3"/>
    <dbReference type="GeneID" id="9584739"/>
    <dbReference type="KEGG" id="tve:TRV_05954"/>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="220"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="622" mass="69647" checksum="5ACF6710B43CA9CE" modified="2010-05-18" version="1">MASLSEGLFKSLPAPKYTGENEELPAHAQRRGPRVVGADAIDETQIVVKVSGFVSCFFMGFGSLCSSFVSNGVLFLQRAGPPPYGKRVGWRPRSLEDFGDGGAFPEIAVAQYPLDMGRKDAANKSNALALQVDAEGKVKYDSIAKQGHNENRIVHASFKDLIPLRQRVDMGEISLDRPSQEEVNAQMEKTKAALEKLVTGAVSAQKPKNVATGKRSEPTFVRYTPANQMGNTNRKNDRIMKIVEKQVDPLEPPKFKHKKIPRGPPSPPPPVLHSPPRKLTAEDQEAWRIPPPVSNWKNPKGYTVPLDKRLAADGRGLQDVSINDKFAQFAEALFTADRHAREEVKQRAQMQQKLAEKEKAKKEEHLRQLAQKAREARAGASSSRNESRARSRSRSGSRSPSPYSSRSPTPDEEDEAVRERERRRRERRQEDERKLRQSRMGAERRVQVMAREQNRDISEKIALGLAKPTQSKETMYDSRLFNQTSGLQSGFNEDQPYDKPLFAAQDAINSIYRPRAQMDDDDENAGGAEMDRINRGNRFEVLGRAKEGFKGTEDAEAREGPVEFEKDTADPFGIDGMIAEVTGGQSSGGQKRYGIQEAESSQRGSKRARVDDDEDDDRHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR5</accession>
    <name>D4DFR5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019915.1">
        <property type="nucleotide sequence ID" value="XM_003019869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR5"/>
    <dbReference type="GeneID" id="9584666"/>
    <dbReference type="KEGG" id="tve:TRV_06016"/>
    <dbReference type="HOGENOM" id="CLU_2724036_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="72" mass="8152" checksum="187239375E192407" modified="2010-05-18" version="1">MARSDDSSSYPGPGCKERREREKEKRDTKLAGNRANAILTKGEEKTEERGRRIERDEGDEGEEEEVKLEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFT1</accession>
    <name>D4DFT1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019931.1">
        <property type="nucleotide sequence ID" value="XM_003019885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFT1"/>
    <dbReference type="GeneID" id="9584683"/>
    <dbReference type="KEGG" id="tve:TRV_06033"/>
    <dbReference type="HOGENOM" id="CLU_1796056_0_0_1"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055546" description="Rhodopsin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="151" mass="16786" checksum="3F739617927B9611" modified="2010-05-18" version="1">MIAAIIKTIFLASLTARSDYTYDTISLTIWTNTEQYLIVIEACIPPLGPLLKIAMGKTPTAQQSSSNKYASKHYSGEQQIKHPVFIPKDSLLSTNESSCYPLREYKGRSRIWGDGSEGVVDLDFREARASQLSGIMKTTEVHIESNKDPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG50</accession>
    <name>D4DG50_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation diffusion facilitator family metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019775.1">
        <property type="nucleotide sequence ID" value="XM_003019729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG50"/>
    <dbReference type="GeneID" id="9583720"/>
    <dbReference type="KEGG" id="tve:TRV_06152"/>
    <dbReference type="HOGENOM" id="CLU_013430_4_0_1"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="99"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="326" mass="35261" checksum="0D338AE739DEAA35" modified="2010-05-18" version="1">MAFTCGLPSISVQVRLLLVIAISTCFLITELAVGFKTHSLALIADAFHYTGDLLSFVIAYLAQKHASALGRDIIPEETGIELEAAENRTAIIRIDQKDGRHVLPLLAAFFNSVFLLALGLAIFLQGLEKFVHLDEIANPQLVLIIGCVGILTNVVCACILGADGHHHHGHSHGHSHGHSHGHSHSHEHDPHAHPHEHHHDIRSDEEKLSHGTALSIKAVLLHVAADALNNLAVIVSAAIIWKVPTQSSPEDRPHHDSEHNHYGSPHAKYYADPACTVFIAILIMASTGPVVLQSGRALVAAATGTSVKEILSDTQSKEDKEEKHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGM1</accession>
    <name>D4DGM1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019654.1">
        <property type="nucleotide sequence ID" value="XM_003019608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGM1"/>
    <dbReference type="GeneID" id="9583554"/>
    <dbReference type="KEGG" id="tve:TRV_06326"/>
    <dbReference type="HOGENOM" id="CLU_102236_2_0_1"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20868" checksum="FC4931E0EBA0FA5A" modified="2010-05-18" version="1">MAADTGLYNSSEPVHTMPSPAPNDSNSNGTTNGTHPTANHDNENSHPSPTSSSSSVSDVESERKSRADRPRIASRKPSASILVPRDHPEIEIEKEEFPPDDARAMSPRRNFADVKRLGTQARLTLKEQAKTLQSSLQALADRIDEVKSDHDKLENENRFLQDYIGGLTRTMSTKSELTSTSGAGKGKKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH36</accession>
    <name>D4DH36_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000370">
        <property type="protein sequence ID" value="EFE38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019476.1">
        <property type="nucleotide sequence ID" value="XM_003019430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH36"/>
    <dbReference type="GeneID" id="9577926"/>
    <dbReference type="KEGG" id="tve:TRV_06491"/>
    <dbReference type="HOGENOM" id="CLU_1210557_0_0_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="229" mass="26007" checksum="82A44609CDBFB3E7" modified="2010-05-18" version="1">MACDQKAASRAVARIIPAFLGGLIVYGCYSITKALCITFYVLLIFLVTTYLRLLITVIFFPGYLPRGPQWSGSSRQKKNKGGKGRHRPGSIDQEKPEAIPYATLGEHNANDEKNVYPFDATGLEAFYMKDIFVCQLDGKPPWCSTCCQFKTDRSHHCSEVNRCVRKMDHFCPWVGGVVSETSFKFLIQFLFYAMLFVTFNGVVMAVFVAEHRKMVNIYTFDLYHVVYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH56</accession>
    <name>D4DH56_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000372">
        <property type="protein sequence ID" value="EFE38822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019467.1">
        <property type="nucleotide sequence ID" value="XM_003019421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH56"/>
    <dbReference type="GeneID" id="9577917"/>
    <dbReference type="KEGG" id="tve:TRV_06511"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_4_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="29603" checksum="8E05BCA1D2F76CA4" modified="2010-05-18" version="1">MPYPSPYPPIDIPVVDLWKFLFENEKREFPDDKVIYQDADTLRSYTYAEIKSTAITFGTGLRASFDWKKGDVLALFAPNDIDIPPVLWGTHWAGGVVTPANPAYTADELAFQLKKTRARFLVTHMSCLDVAVKAAAKVGLPDDCIVLLGTERHPTLKYKHFSSVRNLSGATRYRRARIDPKKDLAFLVFSSGTTGVPKGVMLSHYNIVSNILQLKAGEEGNLTCNGGPDGKGDRMLAFLPFFHVYGNELPLIRATVICINLADLPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH72</accession>
    <name>D4DH72_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019447.1">
        <property type="nucleotide sequence ID" value="XM_003019401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH72"/>
    <dbReference type="GeneID" id="9577897"/>
    <dbReference type="KEGG" id="tve:TRV_06527"/>
    <dbReference type="HOGENOM" id="CLU_045011_1_1_1"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30158" checksum="BB4FEF63C341724B" modified="2010-05-18" version="1">MEKRPRALLFDVGGVCVISPFQAILDYEKANKIPIGWINYSIQHTSPDGAWHRLERGEVPLDAAWFKSFNSDFRHLHLWKKFLEQSSTRPAGENDKKIPDMPSVDAEYLYWEMMRVAQSPDPYMFPALQKFKDSGLFIMGALSNTTIIPEETSKLDKTSDHAGEQVKRFFDFFISSAHTGLRKPDPRIYELALREINDARKAKGIGGGDIRAEEVVFLDDIGVNLKWARKAGMGTIKVDLGRTREAVKELERRTGLTLLESKPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHG7</accession>
    <name>D4DHG7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="13" type="ORF">TRV_06623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019342.1">
        <property type="nucleotide sequence ID" value="XM_003019296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHG7"/>
    <dbReference type="GeneID" id="9577664"/>
    <dbReference type="KEGG" id="tve:TRV_06623"/>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="36558" checksum="29558B7AC154AB6D" modified="2010-05-18" version="1">MADGSSNTSTQAGNVSSTVQTLRTTLTSETTPLARRFRALFSLKHLACLHPPTEDTIPAIDAIAAAFPSPSALLKHELAYCLGQTKNLHAVPSLRHVLEDKNEDSMCRHEAAEAIGALADTSSLDLLRKLRDDPSEPDVVRETCEIAVDRILWETSEERQTEKVKKSDFTSIDPAPPTALTSEGHSIPALKETLLDTSLPLFQRYRAMFALRDLSSPPDLPTAREAVEALAEGLKDKSALFRHEIAFVFGQLSHPASIPSLVAALSNKEEAGMVRHEAAEALGSLGDEEGVEEVLRKFLDDPEVVVKDSVVVALDMAEYEKNGELEYSLIPEPAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ7</accession>
    <name>D4DHJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019309.1">
        <property type="nucleotide sequence ID" value="XM_003019263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ7"/>
    <dbReference type="GeneID" id="9577631"/>
    <dbReference type="KEGG" id="tve:TRV_06653"/>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="244"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46439" checksum="EB24C89916EE6D4D" modified="2010-05-18" version="1">MAAPFGSPVPYAEPQWYSRDCSPYHDESHRKLRAFVRDYVEMELMPYAHEWEEQGFVPDETVRRFAKNGFCIIDRSKPEYMGGISLPAGIAPGEWDIFHTLIVADELNSIGCPPIMNFGTEQQKLEYLPRVARGEIRFCLGVTEPDAGSDVSGIKTVAKKVGSHYIVNGAKKWITNGIWADYCTAAVRTGGPGHGGISFLIIPLTAEGVTRRRMFNSGVHASGSTFLEFDDVEVPVENLIGKENEGFKYIMSNFNPERLSLASACIRLSRVCVEDAFRYSTVRETFGKPLLANQVIRAKISKMGQLIEPCQAFMDQLAYTIKTSEQTGRKIDIGGMTALLKVMSTRCLEKVCREAQQIMGGAGYNKAGKGSRIEAISRDVRVYVVGGGSEEILRDLSVREELKHMRKVMEAQKRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI32</accession>
    <name>D4DI32_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019155.1">
        <property type="nucleotide sequence ID" value="XM_003019109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI32"/>
    <dbReference type="GeneID" id="9577152"/>
    <dbReference type="KEGG" id="tve:TRV_06839"/>
    <dbReference type="HOGENOM" id="CLU_025028_3_0_1"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62990" checksum="F2C8FB3D7B7BF6C9" modified="2010-05-18" version="1">MVFVYLVSLSRRANTGSLEESIVFDTPKRSFHSLVFVKALIIYYVIYLTRDNFVDVIHLNFLGASTRQAPAVHKDRNLDKHAITTASLLSFGCTNQPGEEEEEHRPLLYFTKVLLEEQRRTGHHGPQGSCSFPRHHDVGDGGLQYPPNQVSANGLPLSSRFSRRTLFPCYTYDDFVEDILFMTDYENRLQMFVGEMGCWLVLFCIDIWKGFIAPRFSSAAPLFTDGYQSIDNADEADDEPGDIHKAEEDTRTQLSGTKVLLLALPACCDITGTTLMNVGLLFVVASIYQMTRGALVLFVGLFSVVFLKRRLYFYQWFALVCVVLGVALVGLAGAIFPDHHKPPVDIVPGDADAVVALIRRAGEIITSAEKHVDPLRVVLGVFLIAFAQIFTASQFVLEEWILEKYAMDPLKVVGWEGIFGFLVTALAMVILHFTVGVTESGRLGYFDAVEGWRSMTGNKTVAITSILIMISIGGFNFFGLSVTRSLSATSRSTIDTSRTLFIWLVSLGLGWETFKWLQVLGFAMLVYGTFLFNDIITPPLKACLPSRDEETREPLLPEEPIEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIF7</accession>
    <name>D4DIF7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018954.1">
        <property type="nucleotide sequence ID" value="XM_003018908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIF7"/>
    <dbReference type="GeneID" id="9582114"/>
    <dbReference type="KEGG" id="tve:TRV_06965"/>
    <dbReference type="HOGENOM" id="CLU_012943_2_1_1"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="64756" checksum="D7251A3BF5238A40" modified="2010-05-18" version="1">MAVNILPVIELDSDYESISSSNSTIDANGYSSPASSISPSPGFRGDDFMSDTDFEAYVHSLSGNDESPSPTPRRAKERTIPAQRVLPPRTHLSEIRYQGRTYRPGKFIELQDGTFIRVNRILQSSDKTVVSGPKFERLENMGSRMPDRPNELCWVIDQGDYSSSSSRHSNASQYRPYSGEVEVPLSAIRRLRIIRLTNKRYSPTLDENRDDGFLFCRMKYTRVWKIRPSVSGRGTADIVEEKITFLLPEDCQSSLSVSREELRNNWRGTVLHKRRYTFGDGFCGAGGVSRGAQQAGLKLSWAFDKSESAINSYRANFPSCLAEHSEVAQFLTSLPRELLVDVMHVSPPCQPFSPAKTIAAAHDEANEACLFSIYRLIELCKPRVATMEQTSGLKQRHPIWLDAIIHSLIELGYSVRWRLVNCKDYGVPQSRCRLILIAAGPGEELPPFPQPTHGDEPGKLPLVTILDAISGIPSTAPDHDLERAERPFERRPYDPRSLARTLTCSGGDNFHPSGTRTFTLREAASLQTFPLNHTFCAPGVMKQIGNAVPPVLARAVFDEVVKSLRNTDCPATGPANTPITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIJ6</accession>
    <name>D4DIJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_07006</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018993.1">
        <property type="nucleotide sequence ID" value="XM_003018947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIJ6"/>
    <dbReference type="GeneID" id="9582317"/>
    <dbReference type="KEGG" id="tve:TRV_07006"/>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055601" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="283"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="788" mass="89551" checksum="D80F079F8663686B" modified="2010-05-18" version="1">MAAISFLWVCILFVLGPVAADDTAAAALAVDTALNQTLLWGPYRPNLYFGVRPRIPKSLLMGLLWAKVDNYQTAQENFRHTCEQNEGMEGYGWEEYDIRNGGRQTIHDSRNTLDLTIDFVKIPGGTDGGSWGARIKGVPRPDAPPNQPTTLIFYAGLEGLGKLGLHNEPNELGYAGDVRLGGNAIGLGDFTIDITRGPDTNTYPERMHPSYDDKPLDRTIVSSMTVPPEALWQGKTILFTQMKKYIEAAVEKFGEGNVPPPPALLTLTNTQGGGNIHYIQKVFRGSFEDVSATFSQKFENIFKPLAPFNKSEYLRFSKEMLSNLVGGIGYFYGDSIVDRSYAPEYDEENEGFWEEAAEARSRAQLTVADPSELFTSVPSRPFFPRGFLWDEGFHLLPIMEWDLDLTELTRNRLQIVKSWLSLMDEDGWIAREQILGPEARSKVPREFQIQYPHYANPPTLFLVLREFMNKASLGKSSGPDSSNNSAYSDNKELGITFLRSIYPLLRRHYFWFRKTQWGDLKSYERDSFSTKEGYRWRGRTVEHILTSGLDDYPRPQPPHPGELHVDLISWMGMMTQSLRDIAGALGETADVEEFTKYETAILRNIDDLHWNKDAKTYCDSTIDDYEDSIHVCHKGYISIFPFITGLLDANHPRLGDILNLIQDSDELWSDYGIRSLSKKDEFFGTGENYWKGPIWINMNYLVLKNLLSVAQVAGPHQEQASEMYTKLRKNIVENVYKEWKNTGFAWEQYNPDTGKGQRTQHFTGWTSLVVKMMTMPDLNTQSSAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIK6</accession>
    <name>D4DIK6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019003.1">
        <property type="nucleotide sequence ID" value="XM_003018957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIK6"/>
    <dbReference type="GeneID" id="9582327"/>
    <dbReference type="KEGG" id="tve:TRV_07016"/>
    <dbReference type="HOGENOM" id="CLU_009614_1_0_1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="633" mass="71602" checksum="4228FA2ECCCF40B0" modified="2010-05-18" version="1">MASNLAPIAQLLEASLDPRQHKQAEAALKQEEAKPGFSLQLLHITASETFAYNTRLASALCFKNFIKRNWTDEEGQYKLPESDVVTIKQELISLMISVPTGIQSQLGEAVSVIADSDFWERWDTLVDDLVSRLSPENIKTNIGVLQVAHSIFKRWRPLFRSDDLYREINHVLGKFGLPYLALFESLDAYIEKNKDNKENLILGFTQLNLMVKLFYDLSSHDLPPMFEENLGAIATLFLKYLMYDNKLLHTDDDSESGVLEFVKAGTFEALTLYVQKYLDVFGSLVEQFIGSSWNLLTTIGQETKYDILVSKALQFLTSIAKISEHAAAFQNEGTLGQVTEKVILPNITLRESDVEMFEDEPIEFIRRDLEGSDSDTRRRAATDFLRQLLQNFEDLVTTVVLRYVEHYLADNAKSPSDNWKSKDTAVYLYSSIAAKGVATASHGVTTINSHVNITEFFQKNIASDLVAETGVQPILKVDAIKYLYSFRSIITKDQWREIMPLLVKHLASSDYVVYTYAAIAVERVFVLTDASGAQIVPASEITPLAGQLLEHLFQLVQKESSAPKVQENEFIMKCIMRVLVVIKDAAVPQTESILNHLIRITEIISSNPSNPRFYYYHFEALGALIRYDMMPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIN0</accession>
    <name>D4DIN0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho guanyl nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019027.1">
        <property type="nucleotide sequence ID" value="XM_003018981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIN0"/>
    <dbReference type="GeneID" id="9582432"/>
    <dbReference type="KEGG" id="tve:TRV_07040"/>
    <dbReference type="HOGENOM" id="CLU_010210_1_0_1"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="186"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="807" mass="89773" checksum="A669328A656B53C4" modified="2010-05-18" version="1">MESTESLDAVVDFPLDIDCALSELFRNDPENEPQGEPPAEADGRRRSTESNDSVAPVSQDGYSFKKWMRSVRNNGTDVQIPRNFVLNWPNGNTEEQSYIKYPDNEPDCPPDEGSDCSSGLINNIETASFSQATLSVANGARTNTVTSTMYSTSVFSSSEAARASLESNRLTRSVSCDEAAWNRAVQRRQILQELLGTEAVYVSGLRALGDTGLGRCVGTLLRLHSTFLDALRAAIPRVPTAAFAASMKWMAKKKTSKKSSTDVHRKSVTSRRMRESVEHRIKSCKNIAAEPNEVQKVAEILMSKLPKFKVYEEYGIKYPLVLQEVEKLRKTVDFEVWDNGTEALSRSLAPIECKELSPNQALTIGDLLAKPIQRVCKYQLFLSDLLKCTPSSDCPAAHEALEKVYQCMIDTVQEINRATGDPVAKDRLAKTLLLRNQLDFTGFGRERDILRDFGPLKVCGVLHITYETTESIVGEYMACALFASHIILAVPRAETRKFGVLAIIATTRAKVENVNEKPGLQCTRTPHSWKLLYVASGDTFELVMTACSPKEADQWKDQLLLNIAPEITVDTPRIGTRVMFPIKRRPVITINETGNMVQPICRLVRIKGTEAAPRRDPTPSVSPSRPQTLLMTPMETLTPNRQARVRMERWLSDIWTCDIIPYPGMPGRGGQFIRAQAGSFFRSLSSRRPFSRRGSSIASATTQSIASNSKSGAAEETNTTAPTSPISKHSTREFDETIDANVQSRSSSPGCTALPQIKSDADEMVQHEALEKRAKYKERTKMDKRTRWGVSIFTAPGRSRRNRLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJU1</accession>
    <name>D4DJU1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromatin remodeling complex subunit (Arp5)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018513.1">
        <property type="nucleotide sequence ID" value="XM_003018467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJU1"/>
    <dbReference type="GeneID" id="9584442"/>
    <dbReference type="KEGG" id="tve:TRV_07459"/>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000054">
        <property type="entry name" value="Actin-like ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="86539" checksum="DB87813B685908D5" modified="2010-05-18" version="1">MVITSSQRIQSPDNSLTVQERREAKLVPFLYNIAEQPLRNNQEFPAELDLRDGYERSRHDPENSAIVIDNGSHTVKAGWSFDESPRLVIPPVASKYRDRKLNRACQFVGYDAYTDATTRGQMRNAFDSGTGVISNWDVVEGLLDYIFIKLGVEGGNGGVDRPIVLTETIANLGYSRKMMNEILFECYSAPSVAYGIDALFSYKYNFGENGLVISSSHSSTHVIPVLGSKALLSNSARLNWGGYHGSDYLMKLLKLKYPTFPSKMTESQIQSLVREHCYVSLEYDKELSGYLDWTGLEDRDRVIQYPFTEHVVVEKTEEELARIAERKKESGRRLQEQAAKMRLEKLVKKEQELEYYKGIQARFANETKKEIRRLLDAEDMKDEAALERTIRELEKSVKKSRNKDLGNEENGDAMEEASFPLLDVPDEELDEAGLKEKRHQKLMKSNVEARQRAKAEKEREKARIAEEQRLDDEKRENEFDTWIEERRQARETILRKIKQRDRLKADAGNRKSLASQIRMRTLANLASDGPKKRRRGGEDDTFGANDDDWGVYRTVATGDASDDEEEEDIDGMLKSVEAQLLQYDPEFTENHTLEAQTDWTKSMIHMFLRGPWPFDAESQREAHQLHLNVERIRVPEVIFQPSIAGIDQAGLVEIAADVVLQRFPAGEDQQRLLKDVFLTGGNTMFEGFEERFRREYRSVLPTGLECSVRRAGDRVLDAWKGAAAWAGSGGLRTASVSRQEYLEKGGEYLKEHNLGNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKI2</accession>
    <name>D4DKI2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="18" type="ORF">TRV_07704</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018254.1">
        <property type="nucleotide sequence ID" value="XM_003018208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKI2"/>
    <dbReference type="GeneID" id="9579869"/>
    <dbReference type="KEGG" id="tve:TRV_07704"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="17">
        <location>
            <begin position="366"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE37609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="479" mass="52428" checksum="E35F180AF37B150C" modified="2010-05-18" version="1">MEKREKLRRQLEAQIAATERQLSQLKQELADLETKQPAPQQPEATRERSADWPLLQDEYRRYGRQMIVEQVGLPGQIRLRKSAVLIVGAGGLGCPAALYLAGAGVGRLGIIDGDQVESSNLHRQVLHRTRNTGKYKVDSAIEYLQELNPHPTYIPYRTQLSPQNAPDIFALFDVILDCTDNPATRYLISDTAVVLGKPVVSASALRTEGQLMILNYPPRLPGDKSGGPCYRCVFPTPPPADSVTSCADGGIIGPVVGIMGVLQALETIRVITSMSENTTPSTGAIVPSLHLFSAYSTPPFRTIRLRPRRQNCAACGTEPSISIESLKNGSMDYVQFCGSLNPVSSLMPNERLSARDYKIWLDSHSNNDKGILLDVRERIQYDICALPGSVCVPISEVLRSSRSSEATNGELPAWVPASIINTDTATPIHVVCRQGNDSQTAVKILKQLGLGQGGKRFIGDIQGGLDSWRRDVDPQFPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR4</accession>
    <name>D4DKR4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HSP70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018213.1">
        <property type="nucleotide sequence ID" value="XM_003018167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR4"/>
    <dbReference type="GeneID" id="9579584"/>
    <dbReference type="KEGG" id="tve:TRV_07788"/>
    <dbReference type="HOGENOM" id="CLU_009958_6_5_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="626" mass="70140" checksum="1BC3AC2A89281563" modified="2010-05-18" version="1">MAPKSAKAKSSNSGKAKKLQSHQIRQEPNLLIPSHKIIVGIDYGTTFTGEKPAYASWRSKLRGDKGPATTWPGPSRDTETVFKAPSRIAYPFENTRINTIRWGFQVEPGTVAYSWTKLLLDQNTVLGAFDDTSLENASKTGILKLPHGKAVVDVVADFLTEVRDHVFKMIEKQVTKEMLRITPIEYWFTVPAIWSDQAKAQTKVAAQRAGFAYNIERPSDQMFMITESEAAAIAALKKTATDGLGASVKVGINLRKDITTYLINEVDPVLSFEELCTGIDRNLYQLMSQRFGKAFDMLPAKKKGPGSEFMRKFEIIKKDFGFNIEEDRIHELPLNMIASTVKSEYFDAEERLVLLSSNDIRQLFDPVVSQIIGLVRKQIDDAEDADDGEINFSGCIHANMDKRIILVGGFGDSEYLRESMKKAFFGITITVPDNPQSAIVKGAALRGLLGLQATTKRCRRHYGFEWSISFRRGIDREKDAYIDKFTGGKMIGNNCKTENWRMALTDKAQGQRYTENHTNTVNYTKTHYSGSSVIKKFVLFSCDLKDAPERVEHTSIKKVGTISVDIADVDFNLFQKKLIGGMLSYKVELSVKVIFGAQDGVLKFETTSQGKVVGKTTIDFTNTKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKT6</accession>
    <name>D4DKT6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000483">
        <property type="protein sequence ID" value="EFE37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018174.1">
        <property type="nucleotide sequence ID" value="XM_003018128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKT6"/>
    <dbReference type="GeneID" id="9579553"/>
    <dbReference type="KEGG" id="tve:TRV_07810"/>
    <dbReference type="HOGENOM" id="CLU_1541225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="174" mass="18770" checksum="C7CD45F5A44C875B" modified="2010-05-18" version="1">MTPSEAVTDTPSALFRLKTGTDSATPSTNGVIAQNLLRLSSLLEDESYKLKARQTCHAFAVEIMQHPFLFVGMLDVIVGLEIGTKSVTGVLGRASATGDDSVKAESDLIRKIRAEAGRTASTSAAVLSMVDVRQSRTDQSSWLRERNPLFKELSSGKDYMLICEAGSCRTVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKV5</accession>
    <name>D4DKV5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018133.1">
        <property type="nucleotide sequence ID" value="XM_003018087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKV5"/>
    <dbReference type="GeneID" id="9579342"/>
    <dbReference type="KEGG" id="tve:TRV_07829"/>
    <dbReference type="HOGENOM" id="CLU_095741_3_0_1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="189" mass="20431" checksum="07CFFE80D637DE97" modified="2010-05-18" version="1">MAEPTSTCQSTSTTPSLTPETDTPNSSTSNLSDDGIRLSPNGIYLTLSEMGQHEKYHWALLIAHSPTAGTVLQQLRPNDEAEWEYSIQPAEVTTSRAMLVALKVGELPDVNAEWLAAVDECVRSSSIRDSEKFSCRAWVMGAIFALADGGFIDLEPCWVKVGMVEEEAKALVAGATSLDTSMVVSSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL38</accession>
    <name>D4DL38_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018076.1">
        <property type="nucleotide sequence ID" value="XM_003018030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL38"/>
    <dbReference type="GeneID" id="9579285"/>
    <dbReference type="KEGG" id="tve:TRV_07912"/>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="403" mass="45562" checksum="C63BF420E244679D" modified="2010-05-18" version="1">MAAELGPTKLNAESHLILDQPLLRLPHELARRNFKTVQRIVEREKEYVIPALKESANASLSGNQDPTQALASLDTMITRMQGLKRKMEALQEEEKSILSQSRKRIEHLEDLFGIQSLVDVKYDRWSKTRLNRLLVDHMLRSGYLESAKQLAHEEGLEDLVDVHVFAQCQRIAESLRRGETKEALQWCGENKVALKKLHNKLEFELRMQQYIEMLRAGERTEARQHAKKYLTPHSETYKSDILRAAGLMVFPPNTDAEPYKTIYSSERWQTLSNLFVKTHHDLLSLTSHPLLQIALSAGISALKTPACHSEYTTSASSATYSSGSSICPICSTELNELARPMPYAHHTKSSVDNDPVVLPNGRLYGRESLCYMSSRSGVSTGKVKDPITSEVFDVSELKKVFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLH7</accession>
    <name>D4DLH7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000506">
        <property type="protein sequence ID" value="EFE37297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017942.1">
        <property type="nucleotide sequence ID" value="XM_003017896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLH7"/>
    <dbReference type="GeneID" id="9579820"/>
    <dbReference type="KEGG" id="tve:TRV_08051"/>
    <dbReference type="HOGENOM" id="CLU_032072_0_0_1"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="574" mass="63252" checksum="25B3216696B050DB" modified="2010-05-18" version="1">MPHVFVMTRPLSARRAVAGRPSVTKPRYALRRRSYPSRTRNLQRQHRLALGGNTRSQKTLTQLNFVLPQDYPGSEDDDGGSQLEAETTDGEERGGPRPKKQTTRDHVRKRKRQRDDRPNRTLTQMVNVDWALPRADKNDSGEHNSRHPRKRRGVEMETILEDVENAVDEEDGDPNPPADNVPKAGENKLEGLPARKGQSSLEISAEQAARHGKMLPPTNPVTPRKQTRWVIPSSQSPESPEITLNSPRTPRSVKNSPVRLSLASPAAPLFNKRRSLLRFDANDYDSQVVPDDGYFGISAPGSPASALSSPRATSDPSISFGEDINARFNATRRERQTQELQASEPGQPESIVYETDGEAKPESMEDVCPNAPGIKGTRKSGSSDQDGPQLSLGSNIEQSSQNIPASTYMSDTMSVYYTRQPMSYAFEKVHASQSSKDISESARYTEIIESSQSNLPSIGDSDNQETLAKARPQHEWENTSSARQNDTEPDQATSALSPVVQVESSQRSGSEVEVEVPGSQALETEIEARRIITCSQLLTESLMESIPGPPNWVPGPHSNDVNDLNDDGTAPHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLP9</accession>
    <name>D4DLP9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017867.1">
        <property type="nucleotide sequence ID" value="XM_003017821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLP9"/>
    <dbReference type="GeneID" id="9583762"/>
    <dbReference type="KEGG" id="tve:TRV_08123"/>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="244"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="541" mass="58332" checksum="3CDA0C968CAF534D" modified="2010-05-18" version="1">MSFLREAEKCLLNQKTFASLNAFITPLERSATWRGRAQAADYRRGKAPSWLISIEQSIDVSISPLDGKLIGVKDNICTSELPTTCGSATLQDFTSPFNATVVDLLENAGAIVAGKTNLDEFGMGSHSIHSHFGPVKNKNGGDEFYSAGGSSGGSAIAVATGQCHAANSSRALGTDTGGSVRLPAAYTGVFGFKPSYGLISRWGVVAYANSLDTVGIFAKDTSTIHDIFGKPERFIMQPLSITNIRILDVVNRYDSRDPTSISPTSRSRILTAVREASARPTRLRVGVPFEYNIHELSPEIRSAWQITLEYLQSKGHSIHPITLPATKQALSAYYVLAPAEASSNLSKYDGVRYGTRDIESADNAGDYLYSNTRGKGFGAEVRRRILLGTFSLSADKIDNYFIQAQKIRRLVQADFDSVFRLQHPLLHAASTTLGSRDLVDKEDAGRNAKIDVIICPTAPSAAPAIKALENSSPIDAYTNDVFTVPCSLAGLPALSVPILFDGEESKSQSVPRHAGVQVIGQFGDDDMVLEVGKMLEEIGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLS9</accession>
    <name>D4DLS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_08153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="ACYE01000519">
        <property type="protein sequence ID" value="EFE37191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017836.1">
        <property type="nucleotide sequence ID" value="XM_003017790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLS9"/>
    <dbReference type="GeneID" id="9583734"/>
    <dbReference type="KEGG" id="tve:TRV_08153"/>
    <dbReference type="HOGENOM" id="CLU_031304_0_0_1"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="41379" checksum="78B9E9EBFEF8A190" modified="2010-05-18" version="1" fragment="single">KHLAYEICRHREASLEPVPASTLMLELTAGVKLTYLAEGAANIVYNISSDPYPSAAPARAPDISGTKPRTGLGQAQAAYPGKLLRLRKKIDSGTPYLEITRRFNSQVRSLFQDEELVSQELVRLPDGLTTACNERLRDDEAQDRRPMKRRGVYLCTDEPFGLLIKDMTASPGSGATLWEFKPKWLVQSPSAPPDSRRCRTCALREKRQFTTSRGATMDKTAEQLQGKRSFCPLDLVSNRLEDIMSAVSVIIDSPDDARRIAAFIYQNPTLLKLRDKQHQMNAVGLEGIHASPEERAISMTLRDCTMFVKVPQKHNEPLELRLGDLDFKSEDGGKLQYWQDTETELIEEGWYLGVHRSQDKNTECALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ02</accession>
    <name>D4CZ02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025777.1">
        <property type="nucleotide sequence ID" value="XM_003025731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ02"/>
    <dbReference type="GeneID" id="9582020"/>
    <dbReference type="KEGG" id="tve:TRV_00039"/>
    <dbReference type="HOGENOM" id="CLU_066685_1_0_1"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="32744" checksum="FE29E629B91E960F" modified="2010-05-18" version="1">MPSQAPSLAAHSLAPSSNYSSYTHNNTEEKRPLQMEVPKFPLAGPGYVILNLVRVMNIISLLVVIAANIILLIKIVLVTNFFFFEAVTHVASASVCSFLIVSELSVFRAYFDRNWPLLGEDSGFVTLGATMVLLGISTLGELNNQSTRQKEIGLPFWKLILGAGVVSIVIGTLNIGLSYVFRDPDIGISARHVRARGAVATQEVVTRKDSYRSFKLSHKASLNTYKSSSTTPRIGSIRHKRHPQPPNGYPVHISSPLDAFSTPPANASRSPAPMPVPMPMPSAEIAAPNLAHHPAMYSNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ95</accession>
    <name>D4CZ95_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_00136</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000006">
        <property type="protein sequence ID" value="EFE45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025686.1">
        <property type="nucleotide sequence ID" value="XM_003025640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ95"/>
    <dbReference type="GeneID" id="9581928"/>
    <dbReference type="KEGG" id="tve:TRV_00136"/>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="27"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="527" mass="58080" checksum="F2FF418F470E16E5" modified="2010-05-18" version="1">MAPKGKNSFTLKTPKGTKDWSGPDALLRDNIFSTITNVFKRHGGMALDTPVFELREILAGKYGEDSKLIYDLQDQGGEICSLRYDLTVPFARWLAMNPDVRNIKRYHLAKVYRRDQPAMTKGRMREFYQCDFDIAGAKFDPMVADSEVLKIVTEVFEDLGWKGKYTIKVNHRKILDGLFEVCGVPQDKIRTISSAVDKLDKLTWEDVRKEMVDEKGLDGAVADSIQTYVVRKGGRDLLESLLTDEKLTANASAKAGLDDMALLLEYLEDFGVVDKISFDMSLARGLDYYTGLIYEVITEGSAPATATSAPEAQALQRSSKKDKKVDPDEDRSNDPSVGVGSVAAGGRYDDLVGMFSPKAQIPCVGVSFGVDRIFSITKARMQRESNANALRSSEVDVYVMAFGGKGFTGLLKERMQICRSLWEAGIKAEFSYKVKPKLPAQFKAAETNGIPFAVILGEDELAAGQVRVKEMGLPDGHPEKEGVLVDVDSLTTEIKQRLEKKASGADAPAEAPVDEPADLAQKVKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZG7</accession>
    <name>D4CZG7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025569.1">
        <property type="nucleotide sequence ID" value="XM_003025523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZG7"/>
    <dbReference type="GeneID" id="9581807"/>
    <dbReference type="KEGG" id="tve:TRV_00209"/>
    <dbReference type="HOGENOM" id="CLU_018451_0_0_1"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="719" mass="79227" checksum="C6C605306F1075B0" modified="2010-05-18" version="1">MVDVHEDDAVPSSPPSLNATEDTLPSSPPPMKPKKKPPVTPRSFRRFFTPRSSLNAPNTRSRSIRNALQEITSSPALNRLGPAFPGVPDSSDCAIASSSPCQDSFRTPSKKRRLSFCGLSSPPLQSSPLRRVRIAPPIFDDASSPKRGNIFAPADEVDEPEAEEPIETLQMPAPLRRSKVLGQTSSSLHVRSFGLSRRSRTTIRASSGINWQDETASFYSKSEDSHACWKGEYPVTPYCTASCNTNSLVAVGDEAGGIRLLDTSPDVENGFSSAYLSFPSMHKNSIMDLEFSSDDKLLATASGDQTSHIIDMTTQTPIYSLSKHTCSVKRVQFQPGSNNNVVATCSRDGSVNIWDLRYKAYDKPAFRLQCSLGDDDDDTLRPPAKMKYAQTSKTITGAHLERARTKSEQESQLRRDDTTVTSVSFLNPGREHLFVTSSESNACVRLWDLRTAYTLRRAAVPLASTRQPDSHSRFRQFGLTSLTFNTDGSRLYTLCRDGTIYAYSTPHLLLGNSPEMSQPNNTPGRRYPAEEAKPGLGPLYGFRHPRLMVGSFFVKLGLRRPADDKTELLSVGSSDNCAILFPTNERYLTPSLASSTNQPPSTTPTTNTSLPPIQSAAEHRLRPCLRRSNSSSSLSDRLEHTIPIYQHGTALVEGHNKEVTAVSWAHGGELVTVSDDLHARCWREGPAARKLRRDGDINGQRWQCGWADVKDPSYDDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZV1</accession>
    <name>D4CZV1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025475.1">
        <property type="nucleotide sequence ID" value="XM_003025429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZV1"/>
    <dbReference type="GeneID" id="9581711"/>
    <dbReference type="KEGG" id="tve:TRV_00344"/>
    <dbReference type="HOGENOM" id="CLU_433600_0_0_1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="167"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="631" mass="71493" checksum="75378DA0E2F2717A" modified="2010-05-18" version="1">MASAVFFLDLKGKSIHQTLLARNYRGDIPMSAVEKFPILLSEAEEESSAVPPCFSSEGVNYLYIRHSNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKELEEESIRDNFVIIYELLDEMMDFGHPQTTESKILQEYDYISHFRIYDWRAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSASGNVLRSEILGAVKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECLVESHSGSRIEYMLKAKAQFKRRSTANNVEILVPVPEDADSPRFRTNVGTVHYAPEKSAIIWKIKQFGGGKEFLMRAELGLPSVKGDDEHGGGMTGGFGGSMGGAGQGGKGKRPINVKFEIPYFTTSGIQVRYLKITEPKVRLPLFISTSILLYRPLYLSGRTHICVTTCHPLVGFVQHSVPRADCQAPWPRLTCCTFPRSRAPCVPSVTFTSSHELWLFVIKCVAFSLLANTDLKSPHNDNFEEKYNAVYEWWMQSIQGIPSLNYFIDLSGYKHNSISYELRVTENPTNEVCASDSCQDAKVAGNNQGNVHSSKGAGGEWDGRERERRKEKREKRKLITCRGLAPLVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D065</accession>
    <name>D4D065_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025398.1">
        <property type="nucleotide sequence ID" value="XM_003025352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D065"/>
    <dbReference type="GeneID" id="9581634"/>
    <dbReference type="KEGG" id="tve:TRV_00459"/>
    <dbReference type="HOGENOM" id="CLU_758890_0_0_1"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="53"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="389" mass="43507" checksum="A9820A26078F4302" modified="2010-05-18" version="1">MPGQAGGGGRKNMILHEQSRNRGDIRPPSTDPLTRDMISPPLSQESAFDSNMIAPQVYSGLEYVSSKLQSNTLHLTLILSRSKPLPIGQGCNLTVFPIGTLSDNERHIFSKYIRRAARKYHLQPKWMALSSSSSGMDSMFNPEYLIDRSLKQNDVLISLEGLTILNIDRTYTLKQYLNALSTPWVTPNTMIDRIPSRIYTDACLYLLRQSVQSTGGRPFAKSFFYHAYNHLHFEDHLIVDIANEYFARYKQVAIVLPKPPASDPVPESDPESKSKGESKPNINPEVIVSKPKEEKAEKQKVEKKEISASSLGTRRVSFAKALSPLRARTPHSASDVTPITRNEWNILVSDSTVGRKKPVQLTVPLEAGCAPDIEGDGVIYDLNWEDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D073</accession>
    <name>D4D073_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00467</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025406.1">
        <property type="nucleotide sequence ID" value="XM_003025360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D073"/>
    <dbReference type="GeneID" id="9581642"/>
    <dbReference type="KEGG" id="tve:TRV_00467"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="261"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="519"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="865" mass="96575" checksum="A0FFAB20AF3489D0" modified="2010-05-18" version="1">MHPAKDGFAALPFFDDFDLSTVDILLISQYVHPPLHVRVISATTPLVSHAQMDIQTDIQTFFSLPFLHVQTCEIRQLTDGSFHLDHSGSLPYVLSKTNFKGRVFMTHATKAIYKWLIQDNVRVSNTSSSSDQRTSLYNEHDHLSTLPIIETIDFNTTHTINSIRITPFPAGHVLGAAMFLISIAGLNILFTGDYSREEDRHLISAEVPKGVKIDVMITESTFGISSNPPRLEREAALMKSVTSIINRGGRVLMPVFALGRAQELLLILDEYWSRHPELQKVPIYYIGNMARRCMVVYQTYIGAMNENIKRLFRQRMAEAEARGDKSVTAGPWDFRFVRSLRNLDRFEDVGGCVMLASPGMLQTGTSRELLERWAPNERNGVIMTGYSVEGTMGKQIINEPEQIPAVMSAKNAAGPSDDQKIMIQRRCTVDEISFAAHVDGVENREFIESVAAPVVILVHGEKHQMMRLKSKLLSLNVDKEVKVKVYTPANCDEVRIPFMVDKVARVVGRLAETSPPIGQDDSRLMDGVLVQNGFKLSMMASDDLREYAGLTATMVTCKQYITLSTASIDLIRWALESTFGLIEEINSPSSEAVKGSNGDSSETQDDSVIKKGEEADEEIPFSELTTYLIMGCVFVKYNPQRREVEVEWEGNMMNDGVADAVMAVLLTVESSPAAVKREYQVFPFAMPVGSSKNKQCHNHAPPLPSNPHSQLTPDERFMRLCMILEAQFGSEIAPIERPKLKYHGGRKERSPSTAEDAGKVDTPDIDEPEDEEELREMEELELARLQSLGIPVPGVEIKVDNHIARVWLETLEVECSYPVLRDRVRVVVERAVETVADMWNTKAGSAMPAKAIPNGSNTIKSEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D096</accession>
    <name>D4D096_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025311.1">
        <property type="nucleotide sequence ID" value="XM_003025265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D096"/>
    <dbReference type="GeneID" id="9582922"/>
    <dbReference type="KEGG" id="tve:TRV_00491"/>
    <dbReference type="HOGENOM" id="CLU_021768_10_0_1"/>
    <dbReference type="OrthoDB" id="4180418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="318" mass="36126" checksum="20048CC65DEE88D9" modified="2010-05-18" version="1">MEKNSRFESQIALNAKALHELSPLVVKISQDNMASHGVLLEESLPAVIQGLNRAIVKSDVLWALGSTVVLGLSEEIAMKAGCGIDIDHIPMMNYIKTRVPRLRAPHIHGVLQDGRRSFVFMTRIKGEPLDRVWKTLDNSQKESIKEQLEIMFSGIRSLTPPPSDEPRALLGGGIPRRCRDARRHVRVAEKPIESMVEFNLFLTTDPNRTETGRLKMIRSFLSSDHKFVMTHGDLHPRNIMVITSNTLPSDAFTPLVKVTGLLDWEMCGYYPDYWEYVKALHTIHPGDGFDDWWNYLPASIGVWPKEYSVDELISRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0I7</accession>
    <name>D4D0I7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025266.1">
        <property type="nucleotide sequence ID" value="XM_003025220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0I7"/>
    <dbReference type="GeneID" id="9580759"/>
    <dbReference type="KEGG" id="tve:TRV_00582"/>
    <dbReference type="HOGENOM" id="CLU_095770_2_0_1"/>
    <dbReference type="OrthoDB" id="2679825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="178" mass="20555" checksum="B084EEB2E841D760" modified="2010-05-18" version="1">MFNKNRLYVALYARGGSPTMPGKEDTYHWAFLVGPKVEGESSKGIRYQVKQRHQIGVGLEWVFEERECPLTPTSMLLVRVIIGKILDMNRLAEILRNTPVREDQPGWNCVAWVKEALESLANDSKALGTSVTEWDKVRNAAMEYCQQKKDQRRFNAWSNFDMNKTPTYNLLELKETII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V0</accession>
    <name>D4D0V0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000046">
        <property type="protein sequence ID" value="EFE44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025135.1">
        <property type="nucleotide sequence ID" value="XM_003025089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V0"/>
    <dbReference type="GeneID" id="9580628"/>
    <dbReference type="KEGG" id="tve:TRV_00696"/>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="25123" checksum="A070F09CB1FCE624" modified="2010-05-18" version="1" fragment="single">RHKSHQLDSRSQPIESTTAITMANPYILASDNSPALLPLLRADPALAARQDEHGYSLLHAAASYNHLDLLRTLINEFKVDVNLTDEDGETCLFVAESVEVARYLVEEAGIDKSKTNDEGLTAAQAITNDGSFPLVAAYLNDIILGEAKGELPPNVKVSFGTTEVNEGDGEGEGDGDADGVVVDAALRARIEELAARGNFHSEEGQRELRGLVTDALRGSGPESAGDGERDTKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D177</accession>
    <name>D4D177_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025020.1">
        <property type="nucleotide sequence ID" value="XM_003024974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D177"/>
    <dbReference type="GeneID" id="9580512"/>
    <dbReference type="KEGG" id="tve:TRV_00825"/>
    <dbReference type="HOGENOM" id="CLU_1219941_0_0_1"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="231" mass="25100" checksum="2B3AB79D0F667495" modified="2010-05-18" version="1">MHQLRLNDAAISLHRVLSAHGVKFGIFGGYAVAALGGPRESKDVDCLACVNKDQILNILDGKSGFVAVPQSRRDYVAFLWSDKPTRERAVLVEIFCEGFPGATFNMSNVVPNVTQIAGETQGSGATSFLDPVYLFKGKLRAAATRSKFHDSADLRWLETYALSILQANKSQFSSLYVGLALKRYPELHHCFERIGLNIDAATNAAAAYDLHHLPPPQPGDVQNGLLATGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1A5</accession>
    <name>D4D1A5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024934.1">
        <property type="nucleotide sequence ID" value="XM_003024888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1A5"/>
    <dbReference type="GeneID" id="9580425"/>
    <dbReference type="KEGG" id="tve:TRV_00853"/>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="93"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="781" mass="87256" checksum="D6AC3CBEBCF0D6C7" modified="2010-05-18" version="1">MANSLARRPSTNGSSHDRGTSFTSIPPSSISPHQSVSIGPRKNRSQTSLSHKSIGSSGESSQRRSVHSYGSFQAQKRRYKSQYPADSPEPHVEYILVASFDVDRGPIMEHQYPSAISGDESMLAELMLPDQTHVRSQDWTIFFLHKDNGGPEEDPEFGEDKDGDDEQDEEKNQDDLSQEYPEEDDAGSAGMDDEPPLIGAMVKAMAICTRHSFLHIYKPLLLLALEDYFKHPFPETLAKLYDSLNAMDLSLMPCLSYLERHILQSTETKDLFVEKFERMIKQRLADERAELERQGIDPQKAGPPSRYTVPRDTHEFESKIVYNDIAIPVKVPTAISPETVGDFSLVKLIQTFAGPHAASPQPFALHPHLTSSGPFTHPIIVLVNALLTQKRVIFLGHNRPSGEVAEAVLATCALASGGTLRGFTRHAFPYTDLTKIDELIKVPGFVAGVTNPTFANHHEWWDLLCDLPSGRMKISNRVEAAPVTEGMQYFQPQNQNSSSSLLGSSSNPPDLTGDVQFMDDILKSIASRHSEGVIRAKWRAYINKFTRISATFEEIVYGATALDIVGPDEPPPDSSPMRERSGESTLRGHGYVWVDEATKQRELAAWVPRIEGWRNTRSYYYFIQDTATMHLVGKPLKGLDVQHHHDRLRTLKLSDVDAKAVYVAFSKSIKDYNSICQLLSVIPETQAGLFYLSMGLFHNDSVVRNATVDLLDRISVHEAGRHFWAQLSRFARLAYYRIKRDKEREVASPLSSPFDDNTSHSIVGVAVSHTSVGTKKGVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1C3</accession>
    <name>D4D1C3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024952.1">
        <property type="nucleotide sequence ID" value="XM_003024906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1C3"/>
    <dbReference type="GeneID" id="9580444"/>
    <dbReference type="KEGG" id="tve:TRV_00873"/>
    <dbReference type="HOGENOM" id="CLU_036411_1_0_1"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="197"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="432" mass="47959" checksum="3117E43F50728F89" modified="2010-05-18" version="1">MDAMEIDSIASPEKKRKDKSESKKRKRQEQASETVVVDDGEKKKKKKKDKHLKKDEKQAVEDGGKGREKEASRKPLSKASSNDKDTHSLSSTADQLPSFHRVTTTLYLPLSPIAISPTHAVSSLLAEHISPLLLTYYPPVRGVVLAYSNPSISATKPTPNTTSTHTPNPEPLTLAKTAGEYGVLHTYLTLTFLVFRPERGQTLEGWINVQSEDFLGAIVFNLFSIGIERRRLPADWKWIAPGQQSDRPSTTSASPTSSSKDEEDDDDDEPDSDKENFKPLASNSEASQFEDAASAETGYFQTRSGKRVRGTIRFRVRDVDVIPGSERDKGFLSLEGTMLSKEDEEKLVAEERSKASGAGRAKGGDNYHDPTSTERQEAPDVDIDLEADEDEDVTMTEAVEAQPSSTKEKKKEKKEKKEKKEKKSKKEKSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1C5</accession>
    <name>D4D1C5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024954.1">
        <property type="nucleotide sequence ID" value="XM_003024908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1C5"/>
    <dbReference type="GeneID" id="9580446"/>
    <dbReference type="KEGG" id="tve:TRV_00875"/>
    <dbReference type="HOGENOM" id="CLU_000960_26_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="108"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="721" mass="79221" checksum="8519CA49B4225109" modified="2010-05-18" version="1">MLIYKAIKKRREENQPGSEPAVNSEKHKEKKLCSHRLGSQSQTSASPLLLNTSKQTYIHPEAGSLEPQQADASLELADLNQRSQIQALGPCELCKKEKHDARVYRRKLIAGLLLPYFLASVDLTIVAAALPFIASHFNKLDQLNWIVTAFTLTSTAFIPAFGQLSDVFGRHFVLQLAMFLMLIGSVLCAVAPSWGVLLLGRALQGTSASGITNLIQIILADKVSLKDNAKNSTIFQFVAGISYSVGPIIGGEFPSPVSEDFLPGLATIDIGGTFLFVFGVGLIILGTAWGGVTYPWTHAAVLTPLVIGSILFVFFFLYEYLLEPERVFGRLLPQQTPMIPSDIIKNRDTIVLAIIEFATGAESLTYLMLIFQTPKAMFSVFYFISIYFTLVEGYEAGRSGLQLLYYIPGIGFGAYFAMFTCNVWPAQTFVPLSAGTVIETVGIALLTWATTTRNIPVVSGMMAVAGAGTGMRFMPATLHVAGIWPDRIAPAMSIMRFSLPFGGTLALTIMGSVFNNKMAEIFRPGSGKGGLDLHNTGQSLEAIDKLPPDIQNYVRNLAKNAVMWAFISIIPIMAISLVAVFFLGNVWIKSKRAKEEAERKAAEDGKIGEAIVSSEVIQVPFLWALITGTVEVNKYISTPLSKAEKEKQAYAVLEEKNRLRALKKDKTYTFRAKDELVFPARVFSKDLYISCDLPSDTQPKKKKKKKKKKKKKNMQSLCTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1V7</accession>
    <name>D4D1V7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024777.1">
        <property type="nucleotide sequence ID" value="XM_003024731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1V7"/>
    <dbReference type="GeneID" id="9580267"/>
    <dbReference type="KEGG" id="tve:TRV_01059"/>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="633" mass="69122" checksum="6A08BEB97169E562" modified="2010-05-18" version="1">MLSGQPIATEFLELPDGKKLKNHGYTQLTSLEADLRRMVSNAKFYNEKSSLLFSNAERIRKIVVAEMPKVNPAYKDPNYAPFSTPLPNNEVEEEDFIDELPEGEEESENEAEAEAEAEVEAEPEPTPREERTRSSRRASGRISTIDRDQNQTDAQKEDPDAAVASKFQAALEGILNEAIRMLDEDGEEKFAPFINLPDKTLYKEYYDVIDHPVSLRGILRTVRGTDRRKPTTSKPKAPNPFRSWKAFIDEVNYLWTNARIFNEDESDIAILAGELEKFINTRIAETRKTVPAPEEESSGTGGGTKIRLKLGAATSTPEPPAAPTTSKLKLRLPARQQQTDTAPATSKVPGVRVDTEALKRQQELVRAGTNGVEVPKPSTNNVQATPTRTLRDRTTSARAPVAAASPTPTAATVNGTGAAPATTGPSLRSRTPLTRRAEAELERETAPKPETSAKPSPSLQAAHAVTPTPAPAAPEPPAKSTSTGATPLSTADWEKLSQARNKAYGNGLISQISISSHSSLPLRQPFHISLPCSPVLPSQPISLTLPSCINLISFNPIIASTSHRRPTQHYFTVCDQKNPTPPTTSVVPFTDYTRFAYDVRLREGVNKLVVGVSAKADGETTERVIVFVNLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A7</accession>
    <name>D4D2A7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024641.1">
        <property type="nucleotide sequence ID" value="XM_003024595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A7"/>
    <dbReference type="GeneID" id="9582816"/>
    <dbReference type="KEGG" id="tve:TRV_01210"/>
    <dbReference type="HOGENOM" id="CLU_1416119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="192" mass="21175" checksum="A77A5627CD68A61A" modified="2010-05-18" version="1">MGYTESIGASPNMIAPFGRSFMSASYNRLHDIYITHSLSLIQPEHLQARGRKKNKKQEKQKKKRKKSADPWVGRSLSGGLLAAFLVSLALLEGVAISSLQFLCLLALAVVAAPRPLPPALRTAAAAAAAAFPTRETQRQGKPDERPKKKKKKVVEEAAEEEETKRQKKSNAVGISILDSKWGHIYKMDLHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H4</accession>
    <name>D4D2H4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024567.1">
        <property type="nucleotide sequence ID" value="XM_003024521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H4"/>
    <dbReference type="GeneID" id="9579891"/>
    <dbReference type="KEGG" id="tve:TRV_01279"/>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="222" mass="25056" checksum="BD074AAC13324147" modified="2010-05-18" version="1">MWSFFGGASAQKKKDIPKNAILSLREQLEMLQKRERHLQNQMDEQDAIARKNVTTNKNAAKTALRRKKLHERSLEQTSAQILQLEQHIYSIESANINQETFNAMKNAKAAMEQIHKGLNIEVVDQTMGELQEQHALSDEIVNAITNAPIGEPIDETDLENELEGMEQEQIDNKMIGTGTVPVGDRIDRLPSVANGAIKEKPKAKEEDDEEAELEKLRAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2K6</accession>
    <name>D4D2K6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein (Bfr1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024481.1">
        <property type="nucleotide sequence ID" value="XM_003024435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2K6"/>
    <dbReference type="GeneID" id="9579709"/>
    <dbReference type="KEGG" id="tve:TRV_01311"/>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55098" checksum="EE8CB8CD16205298" modified="2010-05-18" version="1">MATTAKQAAPAQPGEHKVKPEKPDENAYKISLANAEKDLATAQKKLEAIKAKIESATPNNQNSPVAKRQQELRSQLAAIRQQQQGFKASRTALQEKINVLDASIKARFAEQKSQRDRLPFKSVEDIDREIMRLEKEVDSGTMRLVDEKKNLADISNLRKQRKNFSSMDDSKKTIDEMKAQLATLKKGLDNPEAKALSEQYTALQKELDDIKSEQDSVFKNIKSLRDERTKIHNEQQRAWNNVKEIKDNYHKARRANREYEQEAYRIRMERQKAEREIYEREKKKKIADKKLEEASLPAYTDELLTAEGLIRHFDPTFDLASIGLGKSQLPSSAAYRAQVGRTVDDSDIKGVKVIKKDDRDDNYFMGGTGGKKGKKGKKGAAAAQPEPSKFNLSFGVLEDLSRVKVEPPMNQSDVPALIETLVQKVKEWKSNQASKTAENIKKAQEEIDRLEEESKAAETKASGTSTPQVAAETNTEAKTVDAAETPAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L7</accession>
    <name>D4D2L7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024492.1">
        <property type="nucleotide sequence ID" value="XM_003024446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L7"/>
    <dbReference type="GeneID" id="9579714"/>
    <dbReference type="KEGG" id="tve:TRV_01322"/>
    <dbReference type="HOGENOM" id="CLU_028833_1_0_1"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44619" checksum="9B706A4935304599" modified="2010-05-18" version="1">MPKPRPQARKASKVKSTTDTQHRTQSASISLVDSAPISLQQLILNIFADRLAVRPAAAEQESGSGAGTTLREQVQAIKSHLFNRDFDSAFADADPSMLRAYALRWSAGRALAYTGIFEYALRLALNGDQGGRPAGPSSSRAIDIEDLRNRQVVCIGGGAGAEVVALAAAVRWATGLDNPTESNLNLSVTALDVADWQPVIDELSQGCISESVHNSNKKSGVSLPLLKAGDLAISFQKQDVLELSEGELSLLLSPSTRDVTSANERKGKKCTEDPTTVLITLMFTLNELFSTSMPATVAFLLRLTDVTKPGTVLLVVDSPGSYSTLSLGSKGAGSQGESGGRASEEKKPARQYPMRFLLDHTLLTTASGSWECILSEESQWFRRDRTGLEYNVGEGIGLEDMRYQVHAYRRTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I6</accession>
    <name>D4D3I6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024213.1">
        <property type="nucleotide sequence ID" value="XM_003024167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I6"/>
    <dbReference type="GeneID" id="9579251"/>
    <dbReference type="KEGG" id="tve:TRV_01646"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="108"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="594" mass="63342" checksum="45920FFF6FEAE45B" modified="2010-05-18" version="1">MASRAATRLTAFQRSLAAASPRSSLARSLTTAARTGSTTSSTSMMASSRNSSATAIRRLHATAQQLKPAAAATASTTSAASTATSFPQSHERIASPIDTTNFIDNEFTASRAETWIDLFDPATNNLVTRVPQSTEEEMKAAVASAQAAFPAWKATSIMARQQIMFKFVNLIRANWDRLAASITLEQGKTFADAKGDVLRGLQVAETACGITTQMTGEVLEVAKDMETRSYREPLGVVSAICPFNFPAMIPLWCIPIATMTGNTLVMKPSERDPGAAMILAELAREAGFPKGVINIIHGSAKTVDFILDAPEIKAISFVGSNRAGEYIFTRGSANGKRVQANLGAKNHCAVLPDANKNHALNAIAGAAFGAAGQRCMALSTLVMIGETKEWLPEIAERARALKVDGGFEEGADLGPVISPESKKRIEDIIATAEKEGATILLDGRGYKPEKYPNGNWVGPTIITGVKPHMTCYKEEIFGPVLVCLEVDTLDEAIELINANEYGNGAAVFTRSGPTATKFQRQIEAGQLGINVPIPVPLPMFSFTGNKKSIAGGGANTFYGKPGLQFYTQQKTVTSLWRSEDAISNKASVVMPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3L0</accession>
    <name>D4D3L0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024171.1">
        <property type="nucleotide sequence ID" value="XM_003024125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3L0"/>
    <dbReference type="GeneID" id="9579209"/>
    <dbReference type="KEGG" id="tve:TRV_01670"/>
    <dbReference type="HOGENOM" id="CLU_128289_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="19172" checksum="CAFDCFE38C24E44D" modified="2010-05-18" version="1">MFDYLGIFYISDLLRKVKGWFQIPENYDKEVKWIDEMDETFNNHDFLLQESIFLRELFIERAIEGKLGQTVKPLYSGPKNWKEKLRDAGYQHWTIQKEMHERYLNQPDGPISRQYDISLSRKDQILANNPAKYLSQKRLVQLLLTCVGVREEIKVRTWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D456</accession>
    <name>D4D456_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000099">
        <property type="protein sequence ID" value="EFE43360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023978.1">
        <property type="nucleotide sequence ID" value="XM_003023932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D456"/>
    <dbReference type="GeneID" id="9582671"/>
    <dbReference type="KEGG" id="tve:TRV_01870"/>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="592" mass="67553" checksum="C92B8DB82C1EC335" modified="2010-05-18" version="1">MPAVAAKLSKNQQRRAKKKAKKAEVFYYQIRHIDEFELTCNKEQSKSNTETPTTQTEQPATATNPVKSESKPEDSKQNDELDYASTMFAPAEADNELFQLYQDVMGKFDHSEADDSTVKKSDKPEIYFDEDDIPDEEEEDNAEAKISKKKRKQMNKLSVAELKAMVRKPEAVEWTDADASDPKLLVHIKTYRNVVPVPGHWSLKREYLSSKRGIEKAAFQLPKFIQETGIAEMRDAVLEKQDQQTLKQKQRERVQPKMGKLDIDYQKLYEAFFRFQTKPELTRYGEVYYEGKEFETNLKHLRPGELSDELKEALNIPPGAPPPWLINQQRFGPPPSYPAIKIPGLNAPPPPGAMWGYHPGGYGKPPVDEHNRPLYGGDIFGVLQTQQNVQQGEPVEKDLWGELQPPEDEEEEEESEEEEDEEEEDEDVGAGLQTPSGLETPSGMISSIPSEYGGTQSIAGEFDVRKHHRGTETEESTQPRSAYQVIPERETQVKGFFGGDRVYDLKGTTANLPVLGEEDENRKRKRHGDVDVAVDPEALEGHGLDKENLKNLYNSQKKQEENPNWFQEDLSDMIANESRKRLKKDEERRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D499</accession>
    <name>D4D499_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_01914</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023972.1">
        <property type="nucleotide sequence ID" value="XM_003023926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582665"/>
    <dbReference type="KEGG" id="tve:TRV_01914"/>
    <dbReference type="HOGENOM" id="CLU_000443_0_0_1"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="888"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1241"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1274"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1334"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1399"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1448"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1528"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1560"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1590"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1616"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1646"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1746"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1784"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="148"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1979"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1988"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2034"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="2059"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1419"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2110" mass="237713" checksum="C827F3157D67B33A" modified="2010-05-18" version="1">MAPSENPSYDANNQSGSHSIPLQDLSRPPGTVIADGAGRRARSATIEDELPGRQTSVQGIRAIGRPLSRRYERIAENSPTGDRSADGPDNFESVRLSNDAGPSGFDHASFHQSTIGLSFGPQQVRHSGSSTALDGRVGRSDYNSYFGASEDTVGQNGSGSFAGENDSLPLTDSRYLQPISGASVPDAQAQVKRNSNEGRSVHFAGSATGGGSHLGDDLEGGLRSGRSSVRNSHRSATGRLSPSPSPSSALSRASSMMRMVSQRVVNLSNEPEVIESVMRQKSVLKHARMDEPPSLPAMLEYAHDVASSETLNEGGPEKRPPKAKRKHGHPAISPLRGKALGIFSADNPVRKWLCELLVHPATEPIILILIIIQTILLAIESSVHTGRKGSWSSPVVDILFLAIFIIYTLELIARTIVSGFILNPEEYSTLDRSAGFRNAVMIKTRELFSLQRQPSTKKPADPQQMSIIRSFTTMQQQADEVGDSRQQQRIRLARRAFLRHSFNRLDFLAVVSYWIAFALSVLSIDTNHHIYIFKMLSSLRILRLLALTSGTTVILRSLKKAAPLLVNVAFFICFFWLLFAIIGVQSFKSSLRRTCVWVDPLGVSNFTFNQAPDTVQFCGGHLDNVTGLAKPWIHANGRNGTTTPKGHLCPQGSLCIEGSNPYAGTISFDDVLHSLELVFVLMSSNTFSDLLYFTTDSDYLAASLFFIAGFIFLSLWLVNLLVAVITSSFQVIREESKRSAFTADRIDDVGPEDTSFRRVSKLKRLFNRTNYLWIGIIAFGLIVQCLRSSSMSSNRKELIDSTESAVTVILFIEICFRIGVDWRNFFKSRQNWADLILAIITMVMQIPPIRSSGSVYAALSIFQVLRVYRIVLAFSLTRTLIMTVFSNIVGLFNLIIFVFLITFLTSIFAVQLFRDQIPAMDSDGEVTRTTFSNIYNSFLGMYQILSSENWTSILYSATEANSPRGTAWISAAFFIMWFVLANFVVLNMFIAVIQESFDISEDEKRLYQIRAFLQQKQVSESSHGNLALSSIFKFGRGRERYRDPLDHGPAALEMLLKEAVVQDFLDETSPLRPMETQPTEHPPEQQAVQPGFFSRIFNKLTERMLNREPNPFYSKLKFSRDHDELDPAAMAKEVLSAAEQRKRAQRQYLQRYPKYNVSLYIFTPSNPIRRICQRMVGPGRGKSRIEGVDPYKPVWYLFSAFIYAAIVSMVLIACICTPLYQRTYFETHGPGIHNWFVWTDLWFAILFSVEAVIKVIADGFFWTPNAYFRGSWGFIDGIVLITLWVNVVAALYKTGDVSRVVGAFRALRALRLLNVSESARETFHSVIVMGGWKVISAAFVSMSFLIPFAIYGLNLFNGKMKQCNDGDFGYVSLAHCVGEYKSSQFQWQVLAPRAVHNPFYSFDNFGSSLFILFQIVSQEGWTDVLWNAMSITGVDKQPQPFSSQANGLFFVVFNLLGAVFVLTLFVSVFMRNYTEQTGVAFLTAEQRSWLELRKLLKQISPSKRSLSKDNSKFKAWCYRVAVKKHGRWARFITGLLLVHLVLLVLEFYPEVDWWEKTRDALFLFLTLFYIANVVIRLVGLTWSRFRRSSWDLYSILSVVGTFITTLLALINDKSIVFAQLHKLFLVSIALLIIPRNNQLDQLFKTAAASLTSIGNLLATWFILFLVYAIALTQIFGLTKFGGSETGNLNFRSVPKALILLFRMSCGEGWNQIMEDFATMEPPYCTLGENFYRSDCGSAAWARTLLISWNILSMYIFVSLFVSLIFESFSYVYQRSSGLYAISRDEIRRFKQAWSTFDPDGTGYISKEAFPRLLGELSGVFEMRIYEGDFTVGRILEDCRVNVRESEISHSRSVGELDLKKLMLRLSHLPVAEIRKRRARLNAFYEEVLVSSDPERGISFTSCLMILAHYNVITDSKSLRLEEFLRRRARLQRVEEAVRRNVVVGFFNTLYWSRRFRQRIQARHDSRLVSVPQFSVPEIYVEDEDGHMDEDQSRRASEDRARSPEGSPSRKAPRIALPKIETNMFGDEAHRLPSPTHSDWGNFNPSLTPQSPTTPYDSSVPRDESGEGHGHQRGDSSVSVQGVLDSFDHSVWGESIRRSFTRRRSHGSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4S1</accession>
    <name>D4D4S1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000111">
        <property type="protein sequence ID" value="EFE43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023763.1">
        <property type="nucleotide sequence ID" value="XM_003023717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4S1"/>
    <dbReference type="GeneID" id="9582345"/>
    <dbReference type="KEGG" id="tve:TRV_02087"/>
    <dbReference type="HOGENOM" id="CLU_3088987_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="52" mass="5896" checksum="5C143C2276217BF8" modified="2010-05-18" version="1">MHILSPFESFMPSIAVHPQLAWPGLTLSSGLDVQFHLRLDQKKASRAKMYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V7</accession>
    <name>D4D4V7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023737.1">
        <property type="nucleotide sequence ID" value="XM_003023691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V7"/>
    <dbReference type="GeneID" id="9582272"/>
    <dbReference type="KEGG" id="tve:TRV_02124"/>
    <dbReference type="HOGENOM" id="CLU_014024_0_0_1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="704" mass="77878" checksum="33BEC0E5F0E09B67" modified="2010-05-18" version="1">MSFSMAPNGAGSQQPAHLSLNSNAGGLSNNAAPGLNRPPNQHSSNYHLNGTSTPTYLMPTSPPKSRRGSSDGSSPKLETAVGQVPICLVNASITYCGNNEIYAFGGFDQETDEVLQILLLFISALSQVANTSGFSPGHTASFYQGDKLIVFGGENERPEHLNDVIVFDIKTATWTSPEIRGKPPRGRARHASVIYEDKLFVIGGVTGESNLILDDICYLDLKTWTWSRTWRSVVVGSQGYPITREDILNRARYYDAKFIPDNGKQLLTSLDSPNNTPPTTGRLNSFAPNAANTQIRSANSRRKPTAPGAISSLKFHSGPYVPALRSGTHFHVYSSGLLLDLVTPSETVKPWECNLSTMEMDSLRWQKLANGQEIFPVENRWHYCTIDEAGSTAWLFGSSSGNLDLGGDNRLDAILTIDLEKYGVLGREATEQNRILASERQNTLSNLGAGLASVFDQPPESGCGSDFIITADMDDAEFSYGQSEGDERASEFLPEDAARSPPIHVHRIILYARWPHFQRLYAAKMAEYHTNRMHIPEPYRVVRAFLYYLYTDCISGDSEVSPSVLEVAGMLVMANMYDMPKLRLLCVNRLSRELDVDTAAIIWERAGRTDEDWLRRRAASFCLANWGRIVRSEGFRLLSKQSMIDLCEVVDTEARILTGHEAELRDILTERYDATSPRRPRVAVAAGGLEDDLDIDEEDGMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4W2</accession>
    <name>D4D4W2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023742.1">
        <property type="nucleotide sequence ID" value="XM_003023696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4W2"/>
    <dbReference type="GeneID" id="9582277"/>
    <dbReference type="KEGG" id="tve:TRV_02129"/>
    <dbReference type="HOGENOM" id="CLU_2348201_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="97" mass="10796" checksum="455891C67D9B7B11" modified="2010-05-18" version="1">MFSTHLLFGDLILAYPVNIKYVPFICCTYHTLCDAFPPSSSFPALLRALNDSKRPLLSTLITHGIISSTLLFFSFSFLHILLFFNIALVNSSFGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D555</accession>
    <name>D4D555_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023650.1">
        <property type="nucleotide sequence ID" value="XM_003023604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D555"/>
    <dbReference type="GeneID" id="9582196"/>
    <dbReference type="KEGG" id="tve:TRV_02225"/>
    <dbReference type="HOGENOM" id="CLU_106350_0_0_1"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055994" evidence="1">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="188" mass="21479" checksum="7D7BDD4F6B427DAA" modified="2010-05-18" version="1">MIKHVTHLLFLRKVEFFLLFSFFFSSSNKHQEEVEEVKNLLRPASNSFKMRPKVSIAHLARHGGLSLAELPPPFLAPALYSPIISVSRSSKFSTSASFQDRNKNRGVSAIHRSGLKHRLSVSKFKLPVPENPERHEPRVLNPEHGLWEFFLPNKQAFPTPEQEHAHGMGPPRRFQFINPQLVLTNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D582</accession>
    <name>D4D582_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023620.1">
        <property type="nucleotide sequence ID" value="XM_003023574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D582"/>
    <dbReference type="GeneID" id="9582166"/>
    <dbReference type="KEGG" id="tve:TRV_02252"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_13_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122991" checksum="BCDF6F93D6585770" modified="2010-05-18" version="1">MDPLSIAAGTIGIADVCWRVIKYLKDLPAAVAGVQKEIDSLIAEVESLRTVIRSVEEAFEGSFAKSSSESPLRAANLQSLWKDFKRSLEGCQNLATDLEHLVQEIYGKNGAKVTSKLDGLSKENRRRDKAAGLQRVREKLSTEKDNLQILLTGISLYNHHVSQDTLVQMSKDLRSLDQDFKTQIMSLERRIQLSDGIGTEPDQEDISKLSRIKQFRSSVRSVAAAVSITTPNKFFDVPQPVSSFYTGRTMYLEQLQNILFSPVTLGLAPKQLRFVIYGIGGSGKTQFCSKFAEQNRDCFWGVFWIDASSHERIRQTYAEISKLGEVEPNHNAAMHWLSNREERWLLIMDNADDPHIELYEYFPKGDRGCIIITTRNPAHKVYGNMDPGFFEFQGMEDDDAQALLLRAARLSEPWDADSSSWAIKITRQLGFLALALIHAGAAIRNGLCTLKDYLSFYDKNWERIRRTRRLSIDSEDRRDDYMSAHATYEVSYSGIARKGTESSEDAIQLLKIFSFLYFKNIRFDILKKAVINCEIERAEQERKDRQEAERPLTWHQKYKSMQLAVLSYLMQDRSPPALPLSIREGRASGFFDEVRIRYALRELIQMSLITHHETSDSYSMHPLVHKWARERPDMSASEQAVWSQAAATTLAHSILLPPLGETEDDEIFRRDILPHIDHVQKCLQGVNDKIIANRRQRWYGLLDWPGAESRFGREKAVLYAKFSIVFAQNGRWSDAESLQLAVKRYAEGVLGSDHAVTRRITLALALTYWNQGRGDEAADLQDAVLQSCMSSLGPNNHETLMAMDLLGQARWQQGRYSEARMLQQHAVDGLVKIRGPRHEDTLTFMGNLGRTLTKFYENLDDAKQLLTQALDGMKEILGPTHLKTLAVKEEIAMVNVQMEKQLTQSATIIEEVLECRKEKLGKEHPYTLLAMVNLARVNIALGFYDEAEALVRKGLEVADRNLGRKHIGTLMGRTVLGVILTCQSRFDEAEETLLGVIENLRNLSSYRGDFHPDRLGAMIELAKCYKLQGRYDESINLCDETIKGLSKISLKEHPLEKKMKRLKVELIEMKKSNKEREATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5L2</accession>
    <name>D4D5L2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023490.1">
        <property type="nucleotide sequence ID" value="XM_003023444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5L2"/>
    <dbReference type="GeneID" id="9583510"/>
    <dbReference type="KEGG" id="tve:TRV_02385"/>
    <dbReference type="HOGENOM" id="CLU_038380_0_0_1"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="481" mass="52825" checksum="7C7086CC062E2B92" modified="2010-05-18" version="1">MTTTPPPSSAIRTPPTPRYGSRYDNYEPYSPRRSKRIADQQHLFSGSAAALDASTTGLVKEHALRRDQELHQLGISGRATYSPPHSQVSSPKRSSERLDMNSPSLSPPPKNRVRSEPVSSSLPHSSSSSSYRSTMDGNTNSSLAANGMLPTPAKTPRKKQIEDLGPTARTLFSSSSKPAQDPAAMMPKRSKKYSGFSLESFEADPQQASQEPIAIFTDSRDRIPQVNNSPDNPFRSKPAEGEPSSSKLSAEAGKRRKLDESSRKRDKNVDKAIRRDDGLLYVFRGKKVFRKFKPEVEEEDDDDDLGLLASRSELKSESIPRIRPLTRSSIKPRVLFPEARAAPVPCEKEEEPSTPSTIVEAEEEQDEEPDEEPVEESAETADQPATAHAENGSSENPITPEGQIIQTDTPSSPLASGRSLRSHGLKAGSGPEHCDPDTPTAKRISPFDRWRRGKSHSTPTKTKKRGIDGNSNQTSKKSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5P4</accession>
    <name>D4D5P4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023433.1">
        <property type="nucleotide sequence ID" value="XM_003023387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5P4"/>
    <dbReference type="GeneID" id="9583453"/>
    <dbReference type="KEGG" id="tve:TRV_02417"/>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="28780" checksum="136C651AF190B8C2" modified="2010-05-18" version="1">MAETDTAEIQYIDGVKTLVPLGIISTIFAVSGVTNFQMCPAITSLASDLGFYDVYSIDDPDLLAFIPRPVYGLIFICPRDAYYRTRESMGTDNMPEYTGSGPDEPVLWFRQTIKNTCGLMALIHCISNGDAREYIPAGSELDQLFKTAVDLAPTERAQLLYDSPLLERAHRSAARRGDSTVPAPDDKCGFHYICFVKGSDGHLWDLEGGVKGPIDRGLLEEGQDGLSEKALELGVRTFLKHQSDTGKGVDVSGFSIVALAPSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5W6</accession>
    <name>D4D5W6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023387.1">
        <property type="nucleotide sequence ID" value="XM_003023341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5W6"/>
    <dbReference type="GeneID" id="9583407"/>
    <dbReference type="KEGG" id="tve:TRV_02489"/>
    <dbReference type="HOGENOM" id="CLU_1027414_0_0_1"/>
    <dbReference type="OrthoDB" id="4168782at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="271" mass="30577" checksum="A472E8572DF22E6D" modified="2010-05-18" version="1">MYPVFCTTNIPPKVLDWFIDEAYRGILLSEEDSDPPGAPCILQTTDLSSITHGSRKPMSDFESPFLNYTDNEIRDWMEHHPCPGFAEATFTIVDQLTIDEGTCRVGYCNSFPDPQPDTRMFTTIPYNDLSVRVTIELGEISWCEIVEETEGTFTRNDPAAAKRAPETAENIREYVRQHGPAGMTTTAGQLNPRKITKLRRNEAFASHPPVRGMARDEEPPAGFRKKGDPFVLRITSVEESNWESLEDIPRMGSPAMAAKLRHRNKKKKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5X5</accession>
    <name>D4D5X5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_02498</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023396.1">
        <property type="nucleotide sequence ID" value="XM_003023350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5X5"/>
    <dbReference type="GeneID" id="9583416"/>
    <dbReference type="KEGG" id="tve:TRV_02498"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31661" checksum="111CA369A5FD89A1" modified="2010-05-18" version="1">MKTINNTEGVRGLFRGHSATLLRIFPYAAIKFIAYEQIRAVVIPSKKHETPFRRLISGSLAGITSVFFTYPLELIRVRLAFETKQGSKSSLRNIFSQIYNEGSIVASSTDGAASASTAAAVVEKVKPRYGLVNFYRGFSPTMLGMLPYAGMSFLTHDTVGDWLRHPSIEKYTTIPHSGKHTPQGQEQTRSHRPQLTATAELFSGAVAGLISQTSSYPLEVIRRRMQVGGAVGDGHVLGIRETAQKIFLERGFKGFFVGLTIGYMKVIPMVATSFFVYERGKWWLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6D6</accession>
    <name>D4D6D6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023198.1">
        <property type="nucleotide sequence ID" value="XM_003023152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6D6"/>
    <dbReference type="GeneID" id="9583218"/>
    <dbReference type="KEGG" id="tve:TRV_02661"/>
    <dbReference type="HOGENOM" id="CLU_092850_0_0_1"/>
    <dbReference type="OrthoDB" id="5408025at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027915">
        <property type="entry name" value="DUF4452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14618">
        <property type="entry name" value="DUF4452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="237" mass="26319" checksum="35B269114B96B4B6" modified="2010-05-18" version="1">MSALFFAHHSPQHQQQHHHHQQHPAPPTHLPAATAATMSHHQHHQHQHQHQHQHQHQHQHQHQHHHRRRQRLTPSNAGATSTLSSLTTPSTAPAPSTASASSSSSRQFRGVKSMRDLVEAPAITAFRARFEAGRSFDLDDDLEFCPNLLTEDDLQSIHSLAASDRSSLGSASPDSSPSQHQIHPMQQHHINGMGGHMAMSGMMGKIHQPAAVRTRNAIPIVNPSTGMRVSSPTRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6P7</accession>
    <name>D4D6P7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1640 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023084.1">
        <property type="nucleotide sequence ID" value="XM_003023038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6P7"/>
    <dbReference type="GeneID" id="9583104"/>
    <dbReference type="KEGG" id="tve:TRV_02774"/>
    <dbReference type="HOGENOM" id="CLU_063283_0_0_1"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36273" checksum="911504626A417F1E" modified="2010-05-18" version="1">MCQNFHPFPKVIRSFHRQRQQGTALSHQQSTTMPKLQLVVTESPRIVRPSRRRSVETSLRSIFLSGNSSQLNNQRLLPPASSNSLQLVPSYQRHFSSVSYRTSSPLIQKHAAILHQQSSPKLQDTTSGSIPIRHNGVYVATFNPARRAFHQTTVVKKDHHFDTLKVVQRLKNEGFSEEQAVALMKVMSDVIEESMQNLTRAMVSREDAERSAYTQKVDFAKLRSELLNSDSTEAQLTRSSHDKIAGDLAKLNSRLRDEIGRTQASVRLDLNLEKGRIREESNGQEMRIKETETRIEQEVAGVRERVEAVKFSTLQWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D768</accession>
    <name>D4D768_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc knuckle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022960.1">
        <property type="nucleotide sequence ID" value="XM_003022914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D768"/>
    <dbReference type="GeneID" id="9582979"/>
    <dbReference type="KEGG" id="tve:TRV_02948"/>
    <dbReference type="HOGENOM" id="CLU_025398_1_0_1"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="678" mass="74447" checksum="390AFE3B0AA698F2" modified="2010-05-18" version="1">MQGLLSRRKTQPETEPEQAGLEFIMQQKKRITLARCYATVWRVSVGVELACLLCLLVGFFFCVLRGGFFELRDMQLLTKTGPLPWLAFFSFQFRRLFFWIKRQTRPTAIKGLSSTTPGVEYRATGEKKALPEMSGAAEDAACDSRTASVGLAPAKGAQRVTAQSEGAGQPPSVNWNNVRKGKVRTALRRPASKPVTASNSFNKVNGQYWRSGSASEDESEAGTRAEESNAVVKDGSDGDGDRSSDDSTDPSDVDDNDSSILLNMDQPSTENPQLEPQPVHTNEEQPPMPLDTTTTVEIKEETGQLEAEQPAIKDEDIDTTAQTAYTSKYSVPPQTIAELNAEDFKKQLKYILYNSTGNPDPSTPVRCIECFREGHLSDICPNKKGSAAEVPCDLCGSDRHIESQCDLMWKQPHPTYTTGKLFISISCAQCASSQHLIGDCPSMRAPSHSTSWSLKALDPSIISNTSLSSTGVPNGRTNGAIPQLKIKGRAQREPTPEEHELHIRSRPQPPSAPRSNIKFAEGLGRGRNLSSNQPRSNDSGSDRYTPRDSQRDYRERDQYFNPNSRPRSRSPESRYGGNHRRPPLPPSRGRGPPPPSRNPGRDRGKGRGGGGGGGGSQRAGKESSRPIPGRALMDCGFMSVRHIKEEQQSRMTTRGTKHVRSSDLLDFPDYLVKSLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D769</accession>
    <name>D4D769_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022961.1">
        <property type="nucleotide sequence ID" value="XM_003022915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D769"/>
    <dbReference type="GeneID" id="9582980"/>
    <dbReference type="KEGG" id="tve:TRV_02949"/>
    <dbReference type="HOGENOM" id="CLU_021768_10_2_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="434" mass="49568" checksum="9A25A9B01844B1A1" modified="2010-05-18" version="1">MTADARVLILDKPNAAQMNQDLMQAFTEAIQKNPAADLLSLIGRAYVRAHRVVQYRELSDAGQLNLQTANDLYDAVIANPDINLRDRFPSDYDRKYRWAKPKPVVAEPPKPVKPRDWFKERLDNIHSASIVYPLSDQASALLQTHSKSRDYSDEEALATSLKSLVLNSERLFDNIIRGAVVKANDDIAIKVFPDNRDLTEYHNLQYLASHAPDLPVPRVHGLIMLGHYRVMFMSYIQGVTIDKVWSGLSHEGKVSLKEQLGNIFSRLRCLRQDDGQELGGLGGEGVKDYRIMEVFAYKGITTAKAFNDLQFSAKHRASPCYAKLLHSFLEIPNKSLRGAVFTHGDLKKSNIMVKQTSEDPNQYTITGIIDWEDSGFYPEYYESTTISNGQSIMNDDDWYLYMPDCLSPLQFPIYWLVDRLWGNLLWNWRTDIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7G0</accession>
    <name>D4D7G0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_03042</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022818.1">
        <property type="nucleotide sequence ID" value="XM_003022772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7G0"/>
    <dbReference type="SMR" id="D4D7G0"/>
    <dbReference type="GeneID" id="9581542"/>
    <dbReference type="KEGG" id="tve:TRV_03042"/>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005126457" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="344"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="523" mass="57180" checksum="0C10EACF5671000E" modified="2010-05-18" version="1">MPGVRSLLLALAGVSLAPAVLAADASTDSSDVHVLKTDTFKDFIKEHDLVLAEFYAPWCGHCKALAPEYEKAATELKGKNIQLAKVDCTEEADLCQEYGVEGYPTLKVFRGLDSHKPYNGARKSPAITSYMVKQSLPSVSVVTAENFEEVKSLDKVVVVAFIGEDDKETNKTYTALADSMRDDVLFAGTSSAELAKKEGVSLPAVVLYKEFDDRKDVYDGKFEAEALKAFIKSSSTPLVGEVGPETYSGYMSAGIPLAYIFADTAEEREQYASDFKDLAKKLKGKINFATIDSKAFGAHAANLNLIPEKFPAFAIQDTVSNKKYPFDQEKKLTKQDITKFVEGVIAGDIAPSVKSEAVPETNDGPVTVIVAHTYEEIVMNKDKDVLVEFYAPWCGHCKALAPKYDQLGSLYKDNKDFASKVTIAKVDATANDIPDEIQGFPTIKLFPAGDKDKPVEYTGSRTIEDLANFVRDNGKHKVDAYDEKKVEKDGSDVTGKPKDAEAPPKPSDAPESEEKADKEHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7H6</accession>
    <name>D4D7H6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022834.1">
        <property type="nucleotide sequence ID" value="XM_003022788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7H6"/>
    <dbReference type="GeneID" id="9581558"/>
    <dbReference type="KEGG" id="tve:TRV_03058"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="149"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="265"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="364" mass="40039" checksum="87EEBB9414FBBBB3" modified="2010-05-18" version="1">MSLNRKDDNPDDRAALRHGLTQLPAGAAEVFPQAQVKQRNTALAAVTDRLAEPVVAAFIGGGVAGAVSRTIVSPLERLKILLQVQSVGREEYKLSISKGLAKMWREEGWRGFMRGNGTNCIRIVPYSAVQFGSYNLYKKAFEPTPGGELTPLRRLTCGGLAGITSVTFTYPLDIVRTRLSIQSASFAELKNQHQTKLPGMYETMRLMYKNEGGIVALYRGILPTVAGVAPYYRLTVRKVGLNFMTYESIRKVLTPEGDANPSALRKLLAGAISGAVAQTCTYPLLPTYMNSSDVLRRRFQINTMSGMGYKYTSIFDAVRVIALEEGLRGFYKGIVPNLLKVAPSMASSWLSFELTRDFFVGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7H9</accession>
    <name>D4D7H9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022837.1">
        <property type="nucleotide sequence ID" value="XM_003022791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7H9"/>
    <dbReference type="GeneID" id="9581561"/>
    <dbReference type="KEGG" id="tve:TRV_03061"/>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="25225" checksum="2DB24F9472EF59BB" modified="2010-05-18" version="1">MPYFEKRKLTRRAINFLFLGFSLPPILDVSSGLSEYLKSLNALLLEFESFQQIHSVDGGPAATLARARLPHMFKRSGQSTKVRRTSSATEIGLPMQSGGVDHHSELKPMGNMASAGGTSAVSTFPSNSESQDLLPGEEYTFLLTPSLPFDPDYFEIFATLCDVLIDCYSRLVSLVSHPSLCNAAMGELFTKADAKLRKVIVSGIVREFEDASRASAKSEVAGVGRMVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7N9</accession>
    <name>D4D7N9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022741.1">
        <property type="nucleotide sequence ID" value="XM_003022695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7N9"/>
    <dbReference type="GeneID" id="9581431"/>
    <dbReference type="KEGG" id="tve:TRV_03123"/>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46486" checksum="973ACBE5733F66B3" modified="2010-05-18" version="1">MSTTTNSSSISTIFLDQPPSCLQFCPTAPNFLVIGTYLLTVDESDANASSPESSRSGSLQLFKLDTQTYRLCQIQRLSLSHAVFDLQFSIHDPSLFAVALSAGKVSLYKIEKHPQSAGLEVSLCLLNTLRVRDDDTKLNLFLAWIPPFPVEADDSVAPIVGFAVSFSDGQISVFQKHDAYPTIEQESIKETRVEGMPIEVWYLAFQRQYNGQLSLFSGDDFNQVRKITFTNDPDLDIDTVPMNDRGRYHEGGVTAILPLCNQDGEAIILTGSYDQHVRVYQFGARGQILTDLNLGGGVWRLKLLRVENNTVERSQGILTSYLILASCMHGGARVIRVVHYSRHPKVGSTWGINIIAQFTEHKSMNYASDVWQDYNEPSKLLCLSSSFYDKRICIWEAKIQNDEETTRMNERDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7U5</accession>
    <name>D4D7U5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rab small monomeric GTPase Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022718.1">
        <property type="nucleotide sequence ID" value="XM_003022672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7U5"/>
    <dbReference type="GeneID" id="9581407"/>
    <dbReference type="KEGG" id="tve:TRV_03179"/>
    <dbReference type="HOGENOM" id="CLU_880517_0_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35301" checksum="1F0259ADB0C8B362" modified="2010-05-18" version="1">MLCNFNFRWKLQNTKYNQRPSSPPHRPQRALCTQCPILTDRLPQNDSFAARLCVVFPDGALPLSDRLPGNLSLPLLSYILPCSHGVPQEGSIEGGLLAIDKKTASLSDGRWVTDAFLLQIQVIILGDSGVGKTSLMNQYVNKKYSASYKATIGADYLTKEVMVDGRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFETLDSWRDEFLIQANLRDPESFPFVVLGNKIDVEESKRMISSKRASTYCQSKGNIPYFETSAKEAINVEQAFEVIAKSALMQEESEEFNGDFDDVINVNHDSDRDACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V1</accession>
    <name>D4D8V1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022328.1">
        <property type="nucleotide sequence ID" value="XM_003022282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V1"/>
    <dbReference type="GeneID" id="9580875"/>
    <dbReference type="KEGG" id="tve:TRV_03539"/>
    <dbReference type="HOGENOM" id="CLU_2252015_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="104" mass="11503" checksum="9D320954CCB7B59E" modified="2010-05-18" version="1">MTLPTPFTFLSPSAGVDDEDACFCSAFFFFSLSFFLASAGIKVDYIIGRKWMFRSDRLPDHVSPAKPSAYAAAEKGRRSQKHGRQKRQAKGKAKKTIGGIIWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y0</accession>
    <name>D4D8Y0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022357.1">
        <property type="nucleotide sequence ID" value="XM_003022311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y0"/>
    <dbReference type="GeneID" id="9580904"/>
    <dbReference type="KEGG" id="tve:TRV_03568"/>
    <dbReference type="HOGENOM" id="CLU_040343_0_0_1"/>
    <dbReference type="OrthoDB" id="4174431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="516" mass="54660" checksum="C7C92089380C8100" modified="2010-05-18" version="1">MIRFPIEHLRAKCLSLSGCKVHEEEISTDNKKILRTRPRVGCNPPVVIVWPSLFSLEAALCLALSCKERERSRGTQSLNWLGILRGGGGRHTILKPDKMTGGRGRRRCILNCLARVPARVSPFISGRAIPSFLLHQPLSEKCVTFIDRSHSDELISSSPSFDLFLQALLRSISPTCDSRFFHTATMHFFSKTTIALTVALAAFSDATSHGRHRYRHFNRQDSSLSVPLSTGYATPTSSMGEAPAKKPVDTALAGMTSSPAPMGTGTNPKPTPQDPSCTVITSVVTYTLGPGNSVTSYTYTTSVPITHETRTVIPVSSNWHIRSKSTKTNISLQTPVGPQSSVPPTTTRTTTTTSTSTSTEWVTVSEVCTSASQGAPGSAQTKAPENPAGNPGPAPTSAPQPPAGAPGPDNTCPCPPPSTVTVTQATATITATVTQATATVTVTVSTESKPTKAQEAEAGNHAPAMKSPDQATPPFPSPKPTHPAHPSHPPHHSHPSQGMPHGTGSPAYHFPTGLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y7</accession>
    <name>D4D8Y7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022364.1">
        <property type="nucleotide sequence ID" value="XM_003022318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y7"/>
    <dbReference type="GeneID" id="9580911"/>
    <dbReference type="KEGG" id="tve:TRV_03575"/>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1067" mass="121977" checksum="25F2420315A0E9A2" modified="2010-05-18" version="1">MDNMDADQIRNKRLAKLASQATNSSSSPNEESQPSSNAASPAPAPQQQLPQPSSSGGTKPEPDSDANTHTEMKRIRITQAGNQGSAAKGLSKPPETIEEFENRTICNIFRLSLDENRRTDIHGQKLTYLRGVRQDLEEDKAPVRMSVTILDQALLEAASQTDNQKPLSYLLPCWKRISTLFKGFRKPAVGDPKYDIILEARRLCMGYCIFAATMPEMFGSSNTCSDKLNRVESPPSAPLKPHLLLDPDDDQGLNQEFILEALKRVEEDDSILPAFVTAVEEMSQDLSRITLDDDYHPYMMALRNLVRYPAIATAITDSSKFNPATSAPDFETMTILGPWFALSPLHPNVTLKYFSSPKTRDQLFILNAQRSMRMTQQLVQSELLDIINQLIRASKSAREHVLDWFAASLNLNHKRRALNVDPKQVSSDGFMFNITTCLDQLCEPFMDATFSKIDRIELEYVQRKPRVQMRDETKINADQETSDAFYDKTVDGSSNFITEIFFLTVAAHHYGSESLTTKLNDLHRHIRDMQSQIDRFELERPRWAFNPVQLRMFEEALKKYKDRLELGMALEYALQGLLLDELWQSRSMQFMRYVIVWLLRLISKRDFPKEQVQLPLPEEQSEVLKFLPEYFLDDIISNFRFILLNMPQVVASTQGDELVILCITLLQSSNYIKNPFMKSGLVTILYYGTLSRRSGGRGILVDMFNSMPFALGHLLHSLMTFYIEAEFTGTHTQFSDKFSIRYEIFQIIKCIWPNQVYRDKLSVEAKKNLDFFVQFVNLLLNDVTYILDLSFTSFIKIHDTQEELNREGSSMEESVRKEKEEFLDGEKRRAKSTMQLTNETVAMLKLFTEALADSFTMKEIVQRLADMINYNLDAMVGPKSTNLRVDNPAEYGFNPRNMLNEITDVYLNLMDKESFILAVARDGRSYKPANFEKAAEILRKFALKSPEDLAKWDKLQAAVKKAKEEDEQAEEDLGEIPDEYLDPLMYTLMEDPVILPSSKVSIDRSTIRSHLLSDPNDPFNRAPLKIEEVVPDINLREKIEAFKAEKRAARLAEKAAENSDKMETGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B3</accession>
    <name>D4D9B3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022180.1">
        <property type="nucleotide sequence ID" value="XM_003022134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B3"/>
    <dbReference type="GeneID" id="9579074"/>
    <dbReference type="KEGG" id="tve:TRV_03704"/>
    <dbReference type="HOGENOM" id="CLU_003938_0_0_1"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="679"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1101" mass="125733" checksum="6C75DA367B366CC0" modified="2010-05-18" version="1">MASTGPPSEQPVPTVSRQSRSRDDHDTLECGSFTAQKLTDSNVLRPQQHGSPEHLHVTNRRFFIGPLPKGWGQNRRRHWYKSCLGIRDYSSRNQTFSADMSVGYQRQSTRFMGLSSTTRFKPSFPQPDDVEAEVEDQDEEQDEDQDQENRIQQQPPVENGQTAGGSQVGPRVIRSIDAGREAQRRDEDAGYFGLSHPNIKRIQDQQRPKNSPLATNSSLVVRMSSDDNVPEAYFTAPDTEPQSTTPKVNPMPQDNIKSQNRKSTESGQPQSSSSLPYRNSYATTGTSALSTTDGQGLETDVGSLSSLIPHNKPPPSSTPRERRQPKPQQLALQPQEPRGEADQTEAELAESQQPSKLINRVISDRVRYGVEERIENGQRRLQNHLGLSDDSRTNRKQKQQTRRHGEVLRAEKMLVRIDVTAQTVPNLYNDNASLKIETRPVENWREYLVVCRQGYDEQTPYLLQFYKTRVIPQVQGAKVKRKYAHEVKLSQGQANVNLFSTLDKTVVVWHPTKMDGTRIFIMRARAAAHSVEWYTFIRKVLGWKQPSSLFVHAPDLDVSLVLQNPFERFAKDNYDENEGTLLNSMGEEQAVSTGIIRTCMDTLTECSEWSQILDIWKKSEKMGLAWRRYDRIEWIQGGNEERMYGTMAMRTSHDLELRPKRHYPTSTAVEPSEPLMEEPSPIEGFLILLTSQQGTHRRWGKNFSKRLYFYSEDQYLCFCKPTKASIPPAPKRPSVPEAGSSTAPETIRGTPVMYTVDPYPVKNGQISWLHDGGNKSYARYCDQAAYTENRRNTNNLSQTEGYFNLGRVTEIRTVSETESTGTQRNGTNLGTQRSITNRATTSSFSHSDNDHVFELELDDGLVVRLRAYNTETRDAWIHRLRQLTTYWKARVKADINILKSIRQRNLEKLDIDEEQESVIGQFAQKWEVARADASPELFNVCGPSGCRAIKGSVRTFSGEQVPHTHQSRQTILDLRDCYLYSGIITSSDLLYHSQTFDNNHPSHNSTPRIYPSDGWTSADEDTATTFVIWNNTRRVLFHGEEERDGNQKTRRWRHVSRLGTSGRSIVFKARSRAERDLWVLAIETEIDRLQQQEDMRIVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9E4</accession>
    <name>D4D9E4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein Hsp30-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022132.1">
        <property type="nucleotide sequence ID" value="XM_003022086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9E4"/>
    <dbReference type="GeneID" id="9579029"/>
    <dbReference type="KEGG" id="tve:TRV_03735"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="79"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="28630" checksum="E707D70B5C1BE8D8" modified="2010-05-18" version="1">MLFKNNSLQSTLRNIQTPKTTLYKVNKIPSSRNIINTTLSNYHNNKMAFFPRLSGGEFTPLFRLLDDYDAHRACASETNIARSFAPKFDVRECKDGYHLDGETPGVSQKDIEIEFTDPQTLVVRGKTKREYTSTNMNNNAIEEAPTPAAIEDEPESSRRNSHQATVEDEEPATTSRPASPARDNKVTKASNNSVKKADAPSFKYWMTERSVGEFNRVFKFPSRVDQDAVSASLKDGILSIKVPKAAPPTLKKINIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Z8</accession>
    <name>D4D9Z8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosomal RNA small subunit methyltransferase NEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021912.1">
        <property type="nucleotide sequence ID" value="XM_003021866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Z8"/>
    <dbReference type="GeneID" id="9578826"/>
    <dbReference type="KEGG" id="tve:TRV_03942"/>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26422" checksum="66C8C1AE7F5E0263" modified="2010-05-18" version="1" fragment="single">LVAEQHVPVSAQDKDSKRLIVVLSNASLETYRSSHGGGGSGGPGRAANGREEKYSLLNSDEHIGIMRKMNRDISEARPDITHQCLLTLLDSPVNKAGKLQIYIHTAKGVLIEVSPTVRIPRTFKRFAGLMVQLLHRLSIRSTNSEEKLLKVIKNPITDHLPPNCRKVTLSFDAPIVRVNDYVKTLGPKESICVFVGAMAKGRDDFADAFKDDTISISNFSLSASVACSKFCHAAEDAWNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAP7</accession>
    <name>D4DAP7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021684.1">
        <property type="nucleotide sequence ID" value="XM_003021638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAP7"/>
    <dbReference type="GeneID" id="9576767"/>
    <dbReference type="KEGG" id="tve:TRV_04195"/>
    <dbReference type="HOGENOM" id="CLU_1541223_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="174" mass="20090" checksum="71B9BC5F88F19739" modified="2010-05-18" version="1">MFQAGGKPFAIPMLDRWIIFVSNTETLKQLDREPEHVLSLQQALHESEVSRVVVGVLKNKLRSNIPLMSDTLRERVRKSMALEMSPPANEACEKNEWRQVRLMPVLLRIFTSVNLLPLVGEEQVKLTEDKANRPEVYDDVMNFFWSCARAFPIVDMMPSFLTPFVITPLNYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAZ0</accession>
    <name>D4DAZ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021615.1">
        <property type="nucleotide sequence ID" value="XM_003021569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAZ0"/>
    <dbReference type="GeneID" id="9578576"/>
    <dbReference type="KEGG" id="tve:TRV_04289"/>
    <dbReference type="HOGENOM" id="CLU_036632_1_0_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="343" mass="37698" checksum="5E7E232C302110A1" modified="2010-05-18" version="1">MLTRPQLVNVGGVIAISLAVTHGLGRRESKLTEAQVSKAGQDVFASSIMYILAISLAKLSTLSFIERVVPANKYRGAIKGSLIFLLAWTVVSIIVYGFQCGASAPWDPRSTAKCFNIVAFWSAATGIDVFTDLCLIVVPGWILWDLQMNKIQKRIVFGVFASRGVVIAASILRATYLKHIDGSGDSMFDSVPYHVATQCHAMLNTIITCLPGFKPFMDRANTGLLSISFKSRLAGGVYDNTFTEYAMTSLRRVVHPRGIGASGQRQLKSVKGSIQNKLGGTQRSFRPDEYSQHADAFSDSRILTESRSQIEEEGPDKLIIRYTTDWTVHVQDEHRSNSDAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB04</accession>
    <name>D4DB04_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021594.1">
        <property type="nucleotide sequence ID" value="XM_003021548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB04"/>
    <dbReference type="GeneID" id="9578555"/>
    <dbReference type="KEGG" id="tve:TRV_04303"/>
    <dbReference type="HOGENOM" id="CLU_2392086_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="94" mass="10499" checksum="9999E61F6350DC25" modified="2010-05-18" version="1" fragment="single">SLPFLGRFYMSYAPDEEGNFGGQGGYGYKSFEKFIDAITALNEGQVTLDQLDHRGLPTLKNTIATTAILHAGRISLDEQRFVEILRDGDTWTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBL2</accession>
    <name>D4DBL2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021357.1">
        <property type="nucleotide sequence ID" value="XM_003021311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBL2"/>
    <dbReference type="GeneID" id="9578237"/>
    <dbReference type="KEGG" id="tve:TRV_04512"/>
    <dbReference type="HOGENOM" id="CLU_003877_1_1_1"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131858" checksum="2C0DE18DDF9EE567" modified="2010-05-18" version="1">MPDQKSSNDGSRSSPELGRSASYIHIPQLLDDSETASIKRTISEVNLSQLATDAHSPTQTIDVETGKSILRQASLREKAGRRPLRNSKNHNNTATGAATTTTPTATTTTTTATTTTTTTTTTTTTADATTPDTTDNTSTSSNNTPSTPASVNPSVEVTAAPRVSTERTRKAFSKPSFANLTLKPWKTSRSPSPVPTTSTSPSSSPPDPKPTSSVATSSSITSTLSVKTTDTGSSTTTATTSISDSASTSPIESSGTTTPKRGRRPASIVSLKGKSHAESKSNRDSSQHSIRRRPSWDRLVASVSLSSSKQDVPPVPQVPVSQTSRAKPESPKKRDELWHVFRGLDVDYQKFASKSTPLKVNVLRSSFLPVLSRILNHPSNHNLRPEDLDRRTNILNRWWTGLLELLNGRNGQSITGTDRPVYLESIVAIMTRPEWRVPFQSNVSGSSSTSTSRVDLAARSYTSLETTGSDFLAESIHHNIRNTFNQNLLSQVGYSIDRMSVRHTPASLVSFCGKTCAYAFFFCPDVANVLVKLWNISPTLLRNVINEFDPGHDHVLRGVMAEEISSQFPPAVRNLAFSGHSSFLRALRRNTSVPLAAAQINWFGPWAPRWAGRDTDLFFVFLKHFYLLITDLLPSISDMSKRIYVPGFIPVHAQMLIVLQNTLSKHTGLQPTDALHSTASATFDDLLDGAETSASLPLRQTNSLILMSESRLIMTLRDFLADSSMQQLTKQLFIESFCKILKLGARKTSLYDHNACFALCDFVEELIPILPPYCRTNDVSDPLDWDFWLDVCLEMLKSNNSLTEVRTFAFIFTGWAEINHDIRRKERLCLDMLLSTALFTEYFNHWSPMVRGYYHRLICWRLARHDGTQQSELDIRIYQTLLDKLGHIWEQFVNHQSIAEKGLVAPVSTAPCTPAPGRRLIIIRNDYFPPAPSMFVCLDNILPPSMAIRSHNGESSNKAQSLTAEAESTSPQLKKTWKILRTIFKSNSNPKPGEVTPPGSSSPETASTTTASEGRSAGEHPKEDGTGPGPESGSSATPRQAYTFRFCLEWIDRQRWPSRNRQLYPPSLPAPARLFLHALQKPPVNISDSSSGSRSHSRSGTGSEDSSETDSAAEEPDSRVTSGTIAPRPNNASKNLFAARIHPASNGQMNKYAGRALAEWAMVVSECDNFFERRRDEGVPCDRLVEVPTLGADSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC21</accession>
    <name>D4DC21_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021241.1">
        <property type="nucleotide sequence ID" value="XM_003021195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC21"/>
    <dbReference type="GeneID" id="9578086"/>
    <dbReference type="KEGG" id="tve:TRV_04673"/>
    <dbReference type="HOGENOM" id="CLU_007977_2_0_1"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="771" mass="87025" checksum="7C2499CE5EDB3FD2" modified="2010-05-18" version="1">MDSTYRPSFARQKRKISDVDSEEEEEEAYARPSFGFQGFAPASNRSPSPPTMASKPARPAWKNATNNEKSGGGGKSTPMVANSFAARMMAKMGYVEGQGLGTSGQGILNPVETVLRPQGVGLGAVREKSQQAKDEAKREAARRGEVLETSSDEERKLRKKLKEKRLREGTSGGSGASTPRGPAKPKYRTAREIEADAAGLAVPNVLKSLVDATGKEQKLLTSTAGLMTPMEFVNANEGEAWKIARRARHDLEAFADEWKGLSERKKFVELEEAQIVDEMDAQQSKLENITALTNAIEGLEITSSDKDLDKRWEEVTTKLEEIETNYQDLIDECQLPEVAVAAVHPLLKESLEDWVPLSNPKYLVSNFRRLHRFMSRTKKANIETQKYRQSTTPYESMMYTLWLPRVRSALMNEWEVHDPGPATSLMEEWKDLLPGFVYSNILNQVIVPKLTSALKSWRPKSSKNNGSSQHFPWWLFDWLRYLDEHHTDPKAPTGLMSDAKRKFRVLLDTWDLGRGLVHKIEVWKDVLDSEFDKALQNHLLPRLGRHLREEFDVNPQDQDLTAFEDVMKWKPFFKPNVLGLLLSAEFFPKWHAILHLWLTSEPNYDEVGQWFSWWKSQIPDEINAIPEVAAEWNRGLEMMNLALDLGDKAKTDLPPPASSSSSHQKPSHHKHRDKHASGKPAKPQKVHVEEPSFKDIVEEWCGDEGLLMVPLREAHLQSGLPLFRITASANGKDGVLVYLKGDVVWAQNKKIKDTWEPTGLDAGLVARAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC88</accession>
    <name>D4DC88_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_04740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021126.1">
        <property type="nucleotide sequence ID" value="XM_003021080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC88"/>
    <dbReference type="GeneID" id="9577968"/>
    <dbReference type="KEGG" id="tve:TRV_04740"/>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="49"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="31910" checksum="2D9696AA81085E50" modified="2010-05-18" version="1">MAGNSGEPQQAVDGIDGAMASSAQESYSFPNDRLKKVMDDPSKTPLLLVACGSFSPITYLHLRMFEMAADFVKFSTKFELIGGYLSPVSDAYRKAGLASASHRINMCRLAVDKTSDWLMVDPWEAMQKEYSPTAKVLDHVDKIINHDYGGIDVEDGTKRPVRIALLAGADLIHTMSTPGVWSEQDLDHILGKYGTFIVERSGTDIDEAIAGLQPWKENIYVIQQLIQNDVSSTKIRLFLRREMSVRYLIPRPVIDYIEEHHLYEDEGNNASSPNPQEKGKGKSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL8</accession>
    <name>D4DCL8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021008.1">
        <property type="nucleotide sequence ID" value="XM_003020962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL8"/>
    <dbReference type="GeneID" id="9577860"/>
    <dbReference type="KEGG" id="tve:TRV_04873"/>
    <dbReference type="HOGENOM" id="CLU_054969_0_0_1"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32939" checksum="7EEE06833C6B989E" modified="2010-05-18" version="1">MLGKRKREVTVASRKQAAAVKDESTLDTSAQDAQERLRKYFESRFQPLELPGSRSGATLDGSSNAYNTDDSDQGEWDGIEEEDSSEDEDSNGPVPEVVDYSKTPKVRTELVDKATVKKFMSSKPPSLLSDSTKPATTAKTRKGGEEATDDLTTDAANLKNDLALQRLLKESHLLDSASDLNPTGVNRHKALDLRAQTAGAKTSIFTQSNMPMSHRKGISAKATQKEERRRREAQENGIILERPSLAKSKPTAKKRERGIGGPSVGKFVGGTLKLSRRDVMAIQGPKSSKKGGRGSGKGKGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV6</accession>
    <name>D4DCV6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vesicle-mediated transport protein Vid24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000252">
        <property type="protein sequence ID" value="EFE40321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020939.1">
        <property type="nucleotide sequence ID" value="XM_003020893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV6"/>
    <dbReference type="GeneID" id="9577770"/>
    <dbReference type="KEGG" id="tve:TRV_04962"/>
    <dbReference type="HOGENOM" id="CLU_476613_0_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="647" mass="71975" checksum="27722B6D8A73C507" modified="2010-05-18" version="1">MPRLVVGGERGVLEYVGTVSENHRRDVCFSSSRRPVCLLSFVVVVSNLSTLAKEEDDGDDGDEEEEEETHREDEKETRRFKMPGDNETFYLRYYASARYANNSNYRNDSLIRKEMCVSSLLIQEIKRIIKESEILKEDDSKWPQKNKDGRQELEIRLGNEHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALVFSLISLHFKLYIGPFTVDLAILALPRDRMTPFARSSGAALLDSTARLALQLLRLCYSACAPYLRLPAQSILCPTVKAVSMPTHSDISAHTQVSASSNAPTRPTCPPENDRITSWIESAEGRINAAADNGSLTAQSPPTTAGERPDSDSAMTTDEALSPQQREQGQQSQGSEPATGGGSTSTDAATTMHSPGTENIGAAGSGIVESLATAEEVRSPVSDSTAITDDNDETDEPMTPTTSVSAATEIKDEQREPAATAAPAIPDILATHRTSMSFEYSDARSEQQIYTVDVEIKNVDMSESYLCGYLKIKGLTPDHPTLTTFFEGEIIGTKHTFQTRHEDWGATEKTDMHHWSRFPAWRPLSRLAKQPDFTFKDYAQRENIFMRWKEAFLVPDHRVKTISGASFEGFYYICFNQVQGTISGIYFHAKSEKHQQLELKPVENYGCCAAIEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY3</accession>
    <name>D4DCY3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2OG-Fe dioxygenase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020913.1">
        <property type="nucleotide sequence ID" value="XM_003020867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY3"/>
    <dbReference type="GeneID" id="9577734"/>
    <dbReference type="KEGG" id="tve:TRV_04989"/>
    <dbReference type="HOGENOM" id="CLU_054080_0_0_1"/>
    <dbReference type="OrthoDB" id="5307791at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34026" checksum="BF47019823AC1520" modified="2010-05-18" version="1">MAIPVVSPESTAAVADLIRLREQFVKERLIFVESNRMIPILKLLGATHEDMEKIKTVSNSLPDDPTLPFRKSKNARFCFDFEQSKVRRLEFQPFILSAEEDFVRHDSGQVRRFAEVEDDLQGNSTLQALFVFKALIFHGVPFKQRPRLNYETENFVCTLFNLRTVTSPDILGEPALEGVHSDGVDFTMTTFLGSENMAGDSATTFVHDMRAKNALRWNEVNPEHTLGSHQHREFLDTLLFVDHERKHSLSPVYAIDPSRPATRDMLIFFTRKPVVEGHPSHPFDSLNSHTSLSMEVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD68</accession>
    <name>D4DD68_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020849.1">
        <property type="nucleotide sequence ID" value="XM_003020803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD68"/>
    <dbReference type="GeneID" id="9577588"/>
    <dbReference type="KEGG" id="tve:TRV_05075"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="100"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="567"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="677" mass="74547" checksum="39240322B25E1498" modified="2010-05-18" version="1">MAEVDAAKAPVVVEAHQVETVGVPAEYHQHSTKTHLKSFEEYKTLYEESISSPDTFWARLARELVTFDKDFNTTHIGSLKGGDNAWFVGGRLNASYNCVDRHALKNPDKVSIIYEADEPGEGRSITYGELLKQVSSFAWTLKQQGVKKGDTVAIYLPMIPEALVAFLACSRIGAVHSVVFAGFSSDSLRDRINDANSKVVITSDEGKRGGKLIGTKKIVDEALKQCPGVTSCIVFKRTGAEVPWTQGRDLWWHEEVEKYPSYIAPESMDSEDPLFLLYTSGSTGKPKGLMHTTAGYLVGAAATGKYVFDIHEEDRFFCGGDVGWITGHTYVVYAPLLLGATTVVFESTPAYPNFSRYWDVIEKNKVTQFYVAPTALRLLKRAGDQHIHHDMKDLRVLGSVGEPIAAEIWKWYYEVVGKKKAQVVDTYWQTETGSHVITPLGGITPTKPGSASLPFFGIEPAIVDPVTGEELKGNDVEGVLAFKQPWPSMARTVWGAHKRYMDTYFNVYPGFYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAALITHCKAAISVEDGASVAEAAVVGVHDELTGQAVNAFVALKTGNEIGEEIRKELVMQVRKSIGPFAAPKAVYVVEDLPKTRSGKIMRRILRKILSGEADSLGDISTLSDPTVVPKIIEMYEATKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDX9</accession>
    <name>D4DDX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020556.1">
        <property type="nucleotide sequence ID" value="XM_003020510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDX9"/>
    <dbReference type="GeneID" id="9577261"/>
    <dbReference type="KEGG" id="tve:TRV_05343"/>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="310" mass="33914" checksum="F30C1387C8411156" modified="2010-05-18" version="1">MAILAYIFSGLTSYAALTLGLFGLSIKVPRAGFFARCLAAYASLLFCAAYGVLASICLRIAGRGQISQWTVARAFKWTMWLTTGVHFDIIQGQKYLSTRPAVFLVNHQTELDVLLLGAVLPQYSAVTAKRSLARVPLLGWFMTLSGTVFIDRANRETAFKAFDNAASLMKSKGQSVIIFPEGTRSYAREPTMLPFKKGAFHLAVKAEADIVPIVAENYSHVLDVKKMRFTSGAINVKGEISPCTFSVVFVLPPISTKGLTTADVDSLVQPTRQSMLEAMVEMDKMRKIKDIANSQAEEAPRATRATAIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE41</accession>
    <name>D4DE41_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020511.1">
        <property type="nucleotide sequence ID" value="XM_003020465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE41"/>
    <dbReference type="GeneID" id="9584259"/>
    <dbReference type="KEGG" id="tve:TRV_05405"/>
    <dbReference type="HOGENOM" id="CLU_1524762_0_0_1"/>
    <dbReference type="OrthoDB" id="4188844at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="202" mass="22301" checksum="F24FBAE6EF2003B4" modified="2010-05-18" version="1">MDTNTGLSGNSNPFGGSNISKPVPKSGTSLSPSPDNGDIVPRDKNGCYKLDIPVLPPAVFEEADGGDSMEGIEHTGGAEIPVEEGGELAGRDKESMFLLSSFIALGVSSRYKNLFLTKETEIDASFVEMMRHNRSRHINGEPSGMNYRLLPLVFLEIKLVLLEQLLMITLEVFLLVQQNLRDSVLKLEEDNWMFEAEEEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE66</accession>
    <name>D4DE66_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020466.1">
        <property type="nucleotide sequence ID" value="XM_003020420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE66"/>
    <dbReference type="GeneID" id="9584205"/>
    <dbReference type="KEGG" id="tve:TRV_05432"/>
    <dbReference type="HOGENOM" id="CLU_050546_1_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="227" mass="25065" checksum="A6E2E163311A6EB9" modified="2010-05-18" version="1">MSRKFYALSLAHHPDRNKEPGAADKFSSISSAYHVLANPKKRARYDRENSIRIPSASSTTTRPGTGSFSSASTSAGGSQFGSRPASGLSKRRGTFKGPPPSFYANGGYGTTQRQSHEHQAGPHQQEHPEYHHSDVPHFDARSHRRTQSHEDMRRRARRARSVEEQKKRAAEGHSFGGGYDEGSMTMRFLVISGILAVAMLSAGLGRMKMKEPGLQELSARQKESRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC2</accession>
    <name>D4DEC2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ctl transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020430.1">
        <property type="nucleotide sequence ID" value="XM_003020384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC2"/>
    <dbReference type="GeneID" id="9584169"/>
    <dbReference type="KEGG" id="tve:TRV_05489"/>
    <dbReference type="HOGENOM" id="CLU_010891_0_0_1"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="90524" checksum="96818B8EEA0C2F2D" modified="2010-05-18" version="1">MVSEELGSLSYVTDKITDHTPPTYLPWSESCFQNVRWLSYTSLPTAAKAFLLICTLDASRFLSQSQSRIAPGDSSPPREFGDRSRRPDRQTTRPPPSRPYLQRALGNPYSSTASQTFAFSPRSSVHHAPLFHSNNEHLPEEDDERDAADFYALQRSRRHFGASRLAESSEGDEGEDSKHSEHSTGQEDEYSRGTGIRSSWRGKASVIGPAGKTATKPLEEQPEENEEDVSEGSPRSGKGRMVEVRLEDSIKTDAVNVDYDDDDPPPEFTAGGPPIRQFQNQSSHLGDDDDEFQTSAGFIDRESDKQALLNNARPPSSIASEMPATSMARGDPEPPMHDMFWGHMFLLCLSGLFATSFIVYLHTTAPTKLPLLGDTIYATLHSSFGLLGTYTIISIFVALLWLALLRSYVRPLVFTMLIAVPVILISFSLYPFISSFKGTWHGSSIQDKVMRWGSIVPAVMAATWIYSVVKGRHATGKAIDILEFSCRILAANPALLLLGFATIALIALWSWAWILMFTRVFLGGHLASGGKRFFIIDIGTWWLGVYFILVYLWSLGVIAGIQRTTTAAVVSQWYFHRNATPAPTSHDVIRAAFTHALTTLFGTICLSTLLSLLVRIPLIVLPRRISSMISLAAYSCVPTPIAALTNPLTLTYAAIHSQPLVASARSLNQMVFLAPSAATAMTFHPRTFSDASRTDYYSSTLMPYRLAKMLLHATRFMMSLALGFGGWVSTARSLQVSGADGSKGSTMRGSLYAYIVGLIAGTIGWGVLSAMEGVLAGVVDAAVVCWASEVGSVRREARYCREAGHLFGGGSADRMDIEDRSPRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEF9</accession>
    <name>D4DEF9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05526</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020408.1">
        <property type="nucleotide sequence ID" value="XM_003020362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEF9"/>
    <dbReference type="GeneID" id="9584134"/>
    <dbReference type="KEGG" id="tve:TRV_05526"/>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="130" mass="14069" checksum="22414E4FDA2A0A48" modified="2010-05-18" version="1">MAPKAAEKKPSTGGKAPAGKAPAEKKEAGKKKRTKARKETYSSYIFKVLKQVHPDTGISKRAMSTLNSFVNDIFERVATEASKLAAYNKKSTISTREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEM6</accession>
    <name>D4DEM6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020319.1">
        <property type="nucleotide sequence ID" value="XM_003020273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEM6"/>
    <dbReference type="GeneID" id="9584058"/>
    <dbReference type="KEGG" id="tve:TRV_05595"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_7_1"/>
    <dbReference type="OrthoDB" id="4115689at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="190" mass="21342" checksum="2DB7B0CEC9222027" modified="2010-05-18" version="1">MSSPVPDLDGAAVPEEQILGYGRSGLVIRVENTALKIPLRYIRSSDDEVEINTEVIQREQEAYRRLGQCEGVVACLEMSEKSTRLALMENGDLRSYITKIRPSRLLQLFWFREIAYTLSRIHDRRVIVADVSSRNLLLDADLSIKFCDFTESSILPLIANIEAANDNGYSIQTDIGQLGAVIVGDFYVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEW1</accession>
    <name>D4DEW1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000313">
        <property type="protein sequence ID" value="EFE39600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020218.1">
        <property type="nucleotide sequence ID" value="XM_003020172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEW1"/>
    <dbReference type="GeneID" id="9584001"/>
    <dbReference type="KEGG" id="tve:TRV_05701"/>
    <dbReference type="HOGENOM" id="CLU_765461_0_0_1"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="38794" checksum="3C4C0EBA269E4BF7" modified="2010-05-18" version="1">METKSGAKIAIRGKGSVKEGKGRSDAAHSSNQEEDLHCLIMADTEDKVNKAKELIHNVIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGQIGHRKYDCPEQRNFTANIICRVCGNAGHMAKDCPDRQRGTDWRNHGPSVRGKGAGAGDAVDREMEQLMQELSGNAPLPGGEAQKRIEGGPGGYGQGSNSYNGDDVKPWQQREPASNTPPWQRRDDRARDDHGHHDPNAPPPWATGGHRGDRGDRDNRDHHGYQGRDSYNPAPAAGGPPPWQQAAQQAPAMAQTAAYGYAGYQFPTNQVMGAPPGLSGIPPPPPGMASMFAGFQGAPPPPPPPADGPPPPVSSHGFAAIFYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF25</accession>
    <name>D4DF25_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000327">
        <property type="protein sequence ID" value="EFE39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020162.1">
        <property type="nucleotide sequence ID" value="XM_003020116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF25"/>
    <dbReference type="GeneID" id="9583936"/>
    <dbReference type="KEGG" id="tve:TRV_05768"/>
    <dbReference type="HOGENOM" id="CLU_013964_1_0_1"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16628">
        <property type="entry name" value="Mac_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="82403" checksum="BBF1E5F1D2746700" modified="2010-05-18" version="1">MSVVAPAPLPSGSRDIAAEASPEQSPSSFTAVNGRDRSASLMNGQQADMRPSPSRDDSSSSSNSAGAANSNGTVGGHSSGNNGGTASAAASNGANLPLSDKPASADGSRDSPVDHEDAASAQDNGSTTTPTTTTAAAAAAASNTNSSSASSAASAAAAANNNSTGTAASSNKRKRSSIDSHNADLVRSPGPLPADHPHSQPPPAANGNSEHPHHHHHQQQQQQQQQQQQQQQPYTSVERPDEARPGTGNVAWDYEMSSSQRHPKPQQHMDASDAQLAEALQREVQSETPSENASTMEMQSGGGSSAHNMQSQSPSASQVAPKRKRVFSNRTKTGCMTCRRRKKKCDEQHPSCNNCIRGGFPCEGYSVRSTWQKPSQTKGPIPLQSKDRYPEPPNMYMQDMSPQRHDSRMGGPMLPDGSKARPVSVEESERAQAYMTSPNSSVARVAWQKGSWQAANHHMMQDSAPKMEYRDGPVMPDMSRPEPPKADYHHSHANAAGGSNNNNNNNSPANNGSGNNAHQKPGLPVFQSNMEPRPNHAPPRVDPGNYPTQARLALSSMETHVPFEGPTEKSEKEKMLSGEQYRPFDPELVRDREQCKSALWRFTNAGNPLYGISSAEKTRLLTQILQPPPIEPSPDAPPPSTSTPTGSLGPGAVLESPFNCHYGYNINIGEDVLISENCFFADDCSINIGAHTWIGPNVTILSSMAIGSMQERKGSQSRYQGRPVVIAEDCWIGAGCTILPGVTLGRGAYIAPGEVVRSQILPYGFQGLKPNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA3</accession>
    <name>D4DFA3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020076.1">
        <property type="nucleotide sequence ID" value="XM_003020030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA3"/>
    <dbReference type="GeneID" id="9583840"/>
    <dbReference type="KEGG" id="tve:TRV_05849"/>
    <dbReference type="HOGENOM" id="CLU_016938_0_0_1"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="689" mass="76186" checksum="2433D3A3430F5AA4" modified="2010-05-18" version="1">MKENHKISFYFKPAESSPEPQPVAGVKRPSSKDGPCSSSPLTSCPPDLSSPVQLTSSLSEPKQEQVILQDRSRNDSSGAAETSHRQHTPMDEPAVSSFTTVPGSQRVFKDGQIVITASDDDDDDYSINSIAISTDELLAKFLGTSGQNEGSDTDMSGSKGRKRSRAKPKPESKETQTATARTTHKFSLDDLVADAMHDKEREAQVSAAKVLIQESMGKYKTKGKNPTDKDDVYASLVSDTSDPVAARRLKDAVLRTEALRQGISWSFFRDDPPTVDVEPFPILSVDAGSWEGVLREPSSRDRAFLSGVVGEVQKYIPLQNDVLLWILQSGVNSYTPKKDEVLIMCTANWQPVATEPRDELRFAYISTLQVSPEYLIASLVQPSHIDRLFATLGAKSSALDAAKPLVPDTRNVDEEDRKYLLSVLALLSNIAEKLNALTREHTLKILCRLALDETVMNDGAVCAETRRAIPALFGQTKSSVLPEANFQAHELAQNTYQTFKDTTLQCLLLKNIPPITPEISLFRCRLASAFLFMDSSPLDKSDSELINLRKISSQLKGERFKVNEHRPEDKEPFDFANLAALTTILDVAIDSGTLQRSFSDKEGEIEFNKQVDKLADRVKAIFTAIQDSGASHMKRTEAKESLQALHYRLVYTVRTKPVLKKSYFVSSNDDGYAGVSGKRDILEKFLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ2</accession>
    <name>D4DFQ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras GTPase Rab11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019957.1">
        <property type="nucleotide sequence ID" value="XM_003019911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ2"/>
    <dbReference type="GeneID" id="9584709"/>
    <dbReference type="KEGG" id="tve:TRV_06003"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25470" checksum="29F8FB683EDECC9B" modified="2010-05-18" version="1">MANDEYDREIADSVGTCIVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKSQIWDTAGQERYRAITSAYYRGAVGALLVYDVSKHQTYENVTRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTEEAKQFAIPQLTLMVLGENNLSFIETSALDASNVELAFQNILTDLLAEIFRIVSSKALESGDSSANQLGDRKVVEITKTPDSEKKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ4</accession>
    <name>D4DFQ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019959.1">
        <property type="nucleotide sequence ID" value="XM_003019913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ4"/>
    <dbReference type="GeneID" id="9584711"/>
    <dbReference type="KEGG" id="tve:TRV_06005"/>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="86"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="392" mass="43751" checksum="1D3B0FD79005C02D" modified="2010-05-18" version="1">MASVYKSLSKRKKKDTPRVNAEDEDVDMDVMDDFEDDSSEEDEEEDISEGDSEVGSDDDDEKDGGVKTTPKKSSQSQKNPAFMPKTRVLVLTSRGVSYRHRHLVTDLTALLPHTYKESKLDTKKSQGYNFLLNSLADLHSCNVVFFLEARKQGQDLYLWLSRPPNGPTLKFSVTNLHTMGELGTGFAGNCLKGGRGIVVFDPSFDDNVVLQKGNEWRGLVREMLRSVFAVPKRGVRGMKPFVDRVIGIFAVDGKIWIRVYEIRETDVATATKKAEEELQNAAAGEKKKMSKSAASGSKGGPEISLVEIGPRFVLTPIVILEGSFGGPVIYENREYVSPNQVRREIRMKKASRYNASRTGQIDRNVKKTELGLNTESSKDKKVDELDSRVLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFX7</accession>
    <name>D4DFX7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019882.1">
        <property type="nucleotide sequence ID" value="XM_003019836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFX7"/>
    <dbReference type="GeneID" id="9584633"/>
    <dbReference type="KEGG" id="tve:TRV_06080"/>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000104">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="544" mass="60342" checksum="6EB1D57FCCA3D58C" modified="2010-05-18" version="1">MPGQGKAQQHKGRGREPQRKKQKKEKSKAEGGADEVVELDVKTLLENNKRKSEENGEKHTDAETSVSVVHEGKKDSPFPETEVTVSELSSTGEGLALSPNGDHVYVVPFALPGETARVRIYKTIKPKSYSLTDLVEVLKPSEQRDDSLIKCQYFGKCSGCQLQMIPYQDQLQHKKRIIEKAYANFSGLLPELIPAIGDTMGSPMQYGYRTKLTPHFTQPARNRRQEHSSDAPEIPPIGFMMKGRRKVMDIEDCPLGTDIVRSGLKNERKRVAENLQQYPYGGTLLVRESTKRVERNKENEALPSTDKVIRTTFPEYVEEKTYITDQNGISVEYVEDYQFHNIAGTFFQNNNSILPSFTGYVRDNALHPEPKPDATPAESAAAAKSNPKLKYLLDAYCGSGLFTIVLSGTFRSSLGIDVAASSIKCARENAKLSNVPNTGFAAADAAALFKDVPYPADQTLLVIDPPRKGCDTNFLNQLLAYGPTRVLYVSCNVHTQARDVGVLVEGKNGIRYDIESIRGFDFFPQTSHVESVAVLTKAIETKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG36</accession>
    <name>D4DG36_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019850.1">
        <property type="nucleotide sequence ID" value="XM_003019804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG36"/>
    <dbReference type="GeneID" id="9584601"/>
    <dbReference type="KEGG" id="tve:TRV_06138"/>
    <dbReference type="HOGENOM" id="CLU_047842_1_0_1"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="328" mass="36897" checksum="CFF87F858554C46D" modified="2010-05-18" version="1">MSELNSRGSRKKLQQPLDTLSNSGLEKANVNDKLHNFQFTKVDPSSPDEAKFAGIDLSVAAFAVAQTETKRICKEIDDAVVDGKGDLGIWKICENMIFPMLKQAGLDEVLSSRSTASVSGSGDSTYGNRSNLPDKNNSTPSQPICVHPDIPIVTVVRHVYPATLLHALRVLQNKFPMSPLTIRLFESIRSHGRASFVIGSSKELFHELIDFRWRVYNDLPSIVSLLKEMEENGIDFDKRTLELVERIRQRGARAILKARQSDGRNKNSSIKSRSRRTGSNAGVSWWDSPAIRKAYRELTSWAKGMDAQIREFKELEEKAQELWSIKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGU8</accession>
    <name>D4DGU8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019529.1">
        <property type="nucleotide sequence ID" value="XM_003019483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGU8"/>
    <dbReference type="GeneID" id="9578303"/>
    <dbReference type="KEGG" id="tve:TRV_06403"/>
    <dbReference type="HOGENOM" id="CLU_023878_0_0_1"/>
    <dbReference type="OrthoDB" id="5403634at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="45539" checksum="01EB66D2457CB305" modified="2010-05-18" version="1">MVSTRARSTQVRFNRQMTVAPIHAEDTPKLRSVKKSGRGVILTSEKRFHTRKSATSGVKKRYHTPAASTIKTTPRTANSKKQLEKYNAITVHSGKFLNHLMDHKIYYDGYSDVQGHPPAKPRNWDELQEVIKKPHPSLSPERFSDEAFQRFKQKDLRAFNERDVILDSLCIIDMFTGDLRSIARDYLFNNTGPITDGSLCDTKPDIVYGAIPESLRLGIRDELCDTIVPSTRTDLPILPNFFLEAKGPDGNPAIAMRQACYDGTVGARGMHSLQTYNNNEPIYDGNAYTISGIYHYGHLKLYCHHIAPPTEKDECPKHIMTSLCSYSMVNDRDDFIRGASAYRNLRDWAKEKRDIFIAAANEKYEELQDQAAPIESQNYDASFDTQSFPSDSEESDLDNSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGV6</accession>
    <name>D4DGV6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019537.1">
        <property type="nucleotide sequence ID" value="XM_003019491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGV6"/>
    <dbReference type="GeneID" id="9578311"/>
    <dbReference type="KEGG" id="tve:TRV_06411"/>
    <dbReference type="HOGENOM" id="CLU_007073_0_1_1"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="320"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="974" mass="106819" checksum="7FFFA7C3A4F5D780" modified="2010-05-18" version="1">MYCQKDTFTEQSLLYQHDPASAQPAASSSSTTTAAAAAPPATRPAAQPDVKGKEASGKPDGPKEKAKESEVLGRSVPVPNTDHREQRRTADVTDQAQDSQREIHVEDVAPAISSPESSILGRRPSFRDSSRWYTSPKYIRKKGIILTSGILQVVRVRETRKSNPSLSNDSTVSVQDPTTAHGAGGSRLGPGNSNSIHFYDPDDPLPNSEIVTHLCEVFFAPLGCNFPFLQRDRFLCSLKEKQLAPILVDAVCALAARFSLHPLLSVEPVNEAPYPHHGQAFAHRAMCAVVDALACPTLAVVQACLLLAYEEFGSNHDSGLWMYLGISIRMAQDLGIQKLDGMKFRYGCVGLTPKAVIAGQMVDPEASASVSTERIDETHTKDSDTESVEAERAKEREKVDLFWSIFFLDRVISSGTGRPVTLRDDDIEIHFPLDSESVLHIGWPSPYPPLMRIIHLYGRMTDLLNSIKEVKHVTPDVLRRLAGMESDLTGIYQKLSPKLHFNVINFQTYVKAGQGTNFILLHFWFHTLIVLLHQPTLLHSFSGKIQQLFSNSRELSISSAKTIADILAFAELIDVKSFTGNPFTSQPIYIAACAFLMESAFYSVPSSRAESPPPKPASSNQPSKPPETEADRDTAPDRSSNPKHSLLAAAAKENYQRCYKALQSLEKSWAGTKYILTALDQKSKGIWDPLLYTEEEMESTAGVDISLAMAWKKTQASSTNAQTTSDSPRTGSPHGAAPTSLESTNIDPSRAIGWSLTGATNSSQPNLSFLYQLPTTSTDIPAQYPETSQLQTAFQRSPSSNLQSTNIAATQPSLQPFQGHETSSQPRGTPQLPSPAQQNTLSPPYSHLQPDRQSPSSATLNLTRSPGFTSQSTSLPRSQQSVSPGTQLRQDSNTQYNFHTPSPFGNQPMAALDHTHIPGYDNVPLNAQNLTIETQDIDMNNLQNQASFPFSFEGGFMPWLEYLPEDVLHFFGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGX5</accession>
    <name>D4DGX5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019556.1">
        <property type="nucleotide sequence ID" value="XM_003019510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGX5"/>
    <dbReference type="GeneID" id="9578330"/>
    <dbReference type="KEGG" id="tve:TRV_06430"/>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055570" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="246" mass="26123" checksum="399386F00728DDA4" modified="2010-05-18" version="1">MRFSTILSACIAFAGVNAAPAGWSPGSAKWLTEIGDYISKHANQGFPRQPNCDLSKAVLPSNPQLSEVPPDQKLLAVAVGRGTQNYTCAGLSPDQAPKATGAVATLFDASCIASNYPYLLSLLPNVALELTNPSPFTNARGPVDLMVMGHHYFNGEGVPTFDLPKLGICGVKKVDSKDAPSNAMKGVKDEQEGAVSWLMLESTPSSKGQAKRVYRVNTAGGKAPPTCAGLPEQIQIQYSAEYWFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ0</accession>
    <name>D4DGZ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019571.1">
        <property type="nucleotide sequence ID" value="XM_003019525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ0"/>
    <dbReference type="GeneID" id="9578345"/>
    <dbReference type="KEGG" id="tve:TRV_06445"/>
    <dbReference type="HOGENOM" id="CLU_012590_2_0_1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="304"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="547" mass="60984" checksum="FDF68FD7D8DAB2B0" modified="2010-05-18" version="1">MDEPEYKNSTTTTANTTNTTTTTGSPKPKRTASGQMKRVSRACYNCRRRKSKCDLNTIKASAGALGASSAVPPPARPPETSISPQSTENYNQSRYISPYNEHDRYGPSEGHRDTSMDDDDDEDSTGESAIGSGALRNPSDAWQRLTNVAKRGTDAPRPEGGSGGRANTNGAGARKGIFAYRLVENEVLTHGLVMQLITRYADNYHCYFPLVPRKYFNSACLDQFAEEKHLLTAVLTVASKDLTSMPHVHQGCSKYMLELISGIAAGADCDVEAVEALLILAEWEPQGLRPSIEPVGRGEEDRAAWMHVGIALRSGYFLGLDKTSFRNDAATGDTQADNRKRLAWASCYVSDRLISVRIGRAFWSRGPGPMTGLVSHDFPSLQPQSPHDEDYSKIFQAILDLTQLYGNVHDVLYSGMRTSRNMMLMGDYVKYIDDFRVAVSRWYRLWGKMPCASNLNVMLQMSYEYLKLYINAFAFQAAISQALHKPKGDDSVSQRDHLRAAFSNVASMQDSRFIYESVEAAKSYLTILTNYVDPERHLHFMPLRFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH29</accession>
    <name>D4DH29_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000369">
        <property type="protein sequence ID" value="EFE38840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019485.1">
        <property type="nucleotide sequence ID" value="XM_003019439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH29"/>
    <dbReference type="GeneID" id="9577939"/>
    <dbReference type="KEGG" id="tve:TRV_06484"/>
    <dbReference type="HOGENOM" id="CLU_2098607_0_0_1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="116" mass="13231" checksum="DDE75E51C3BCB41E" modified="2010-05-18" version="1">MIILSENKGRYIFNDFFKAWVFNTDLQYSFKDTSSACRSVSVKCAMKVFYKHVANVQPLVNPDLGMPSVTSLEELRLPLHIYQCIKAVLEKSTRLLPPSGRKFGEWEIGLLDLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH66</accession>
    <name>D4DH66_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019441.1">
        <property type="nucleotide sequence ID" value="XM_003019395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH66"/>
    <dbReference type="GeneID" id="9577891"/>
    <dbReference type="KEGG" id="tve:TRV_06521"/>
    <dbReference type="HOGENOM" id="CLU_874902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="318" mass="36044" checksum="E709E7D2D69998DF" modified="2010-05-18" version="1">MKDGQRNQDKQEKEREQNKLTPPQSHRRASFVQPGRAFDGEDLSAAASGGSYIEVGLHRLTATPHSLRQQLDLDQLRARKKPKDKDPRTKDRPKMRQGHVYICRWMEMGPFSTHPDTPGQADRQTKQTSIEQASRDLSNQPTNRPSVSQSVHLLRRQSKREKEGVVKRASSALAGLLHHLEYPPSSNRRSKQVLTLSRLNQRRKRPPGDAHNLPSSKFQLGRKAKKQDSQPTRRISRFISPTDAPCPWGLLAGEDGYQRVTNKQPSIESTDAESCIVIVTPHPGHPRPSSYHLHPPWPAQVARTGNILEIRSFHELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHD4</accession>
    <name>D4DHD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING and UBP finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000378">
        <property type="protein sequence ID" value="EFE38742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019387.1">
        <property type="nucleotide sequence ID" value="XM_003019341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHD4"/>
    <dbReference type="GeneID" id="9577789"/>
    <dbReference type="KEGG" id="tve:TRV_06590"/>
    <dbReference type="HOGENOM" id="CLU_009969_0_0_1"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="370"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="532"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="74474" checksum="A65ACB34A286D75C" modified="2010-05-18" version="1">MPSYFYHLILEVLSHPQASTAHTPSKDAQKHPNTETSLEEYALTLKSLRESVRPFRRKKAKPSPNVATDLANHLATTSLQDTEIHTDHDPRTDTLTIQGVDMVHNEISRGIGSNVISGLATKGKYVPLDLGLTDSVYGIVHLYRDAEETPSLGQDNHDQDLFYLQGVGSSSHAPASNHPSASCPAHASGSRAAGGPAEETLSLDDCTTLCILAVPSYLSPSDFLGYVGEQTMEDVSHFRMVKTARANRYMVLMKFRSGKKAKEWQNTWNGKLFNSMEPEACHVVFVKDVEIQVSSSAAESKFPDMKNDPFPFSDAPSTMSSKPLAPPTPSLIELPTCPVCLERMDETSGLLTILCQHVFHCTCLQRWKGSGCPVCRYTQDDLGKRNVNFAMDEGPSECSVCHSEVNLWICLICGNIGCGRYDGAHAFDHYKETSHSFAMDLTSQRVWDYLGDGYVHRIIQGKSDGKLLELPARGDSALDPPDWSDAVPREKFENISVEYTHLLTSQLESQRVYFEEQVERAADKASKASASALSAQEAAERLARDMEKLQSQYDCLTRETIPSLERDKARAERRAEKFESMSRTMEKQWREEKTMNASLMERVEFLDAEVTKLKAANEDLAEQNRDLTFFISGTERLKNQGEDVVEGTVSVPDPPTSSSKRKGKRKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ5</accession>
    <name>D4DHJ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019307.1">
        <property type="nucleotide sequence ID" value="XM_003019261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ5"/>
    <dbReference type="GeneID" id="9577629"/>
    <dbReference type="KEGG" id="tve:TRV_06651"/>
    <dbReference type="HOGENOM" id="CLU_1129774_0_0_1"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="246" mass="27913" checksum="7AAA03CB7E57C7D0" modified="2010-05-18" version="1">MPNHTLHLTDDSGHKTMECTENRKLEQHNVPDKLPEEALEILKKASKERDLEDFRDGLKIYSKAVPLATYVDIEKLLRQEKLSVYLIALGKLNCKYVVGLYFSDKPQRINLKERWPATPEENLERLAEAGFPLDRQIPKCSNCGIISLLTFCPQEMGHIMKSCKEELSVVERVEVKCVNCKQPGHRARDCKEARVDRFACRNCGKGGHRSNECTEPRSAEGVECKRCNEGIIMNANPTTLATKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHT0</accession>
    <name>D4DHT0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019248.1">
        <property type="nucleotide sequence ID" value="XM_003019202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHT0"/>
    <dbReference type="GeneID" id="9577488"/>
    <dbReference type="KEGG" id="tve:TRV_06737"/>
    <dbReference type="HOGENOM" id="CLU_004759_5_1_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="88609" checksum="4981409A271E8525" modified="2010-05-18" version="1">MSVVSAPQHILKRTNTERSFPSKARPRLSFETEPLASESHLPPLSEDGPSTNRPEAGTAQASAKDKKKGVSFLSRIIGGKKKVQVSEENDDVSELGEPRTTGLDSELFAHPVGYIPRYPPPPKYIKVRAKHTKTRAFDRLFLAQDLKGSPAEAELDSAEFEASAKGNKAVWAAEFSNNGKYLAVAGQDKRVRVWAIISKTEDRHAHETEEEARNGQTAVRLSAPVFKTHPIRLYEGHTASIVDLSWSKNDFLLTTSMDKTVRLWHVTRDECLCCFKHGDFVTSIEFHPRDGRFFLAGSLDCKLRLWSIPDKAIAYSVTIPDMITAVAFTPDGKYSLAGCLNGLCTIYETDGLKPLSQLHVRSARGKNAKGSKITGIDTIVQPPTNENGSVKLLITSNDSRIRLYNFKDRTLEAKFRGNENASSQIRASFSSDGKYAICGSEDGRVYIWPLDSTEKYPDKRPIEFFDAHNSIATIAIMAPTVSKMLLGSTGDLLYDLCNPPPVTLVSATASVISRDQARNDEEPVPPRTPQSLQPLSQQKAEESPAYVARSAHPGGNIIVTADYLGKIKIFRQDCGYHKRRHELWETNSTFSRKLLGRTNSVSTRHSVASSIGRESKTPSERILSWRNSVIGGPDNRSVDNLRGTPEPAGRSGSPSKARKDSPFVDTNKPATPNSTSSQRFGATTFVHHNNQPTPPPRFLSTVNSEESTPFGPNDETPRPFGHNSDKEDPSYISWNKAQADTHHDSAQDTYGGKSALVSNGTTGDDSVEYEEELGCSQCQGKNFRATRLKNGEQRLICTQCGCAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV7</accession>
    <name>D4DHV7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019215.1">
        <property type="nucleotide sequence ID" value="XM_003019169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV7"/>
    <dbReference type="GeneID" id="9577212"/>
    <dbReference type="KEGG" id="tve:TRV_06764"/>
    <dbReference type="HOGENOM" id="CLU_067676_7_0_1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="268" mass="29610" checksum="DD6F4B4C3E3E44DE" modified="2010-05-18" version="1">MASPSALVSSPKVAALLKRLHGESGAQESSFSVVSFWLRKKIMAMIFGNRRWNSADDDFMRDKYICLEADKSELVYLLARSTGALNIVEAGTSFGVSTIYLALAAGQNAAAKASGSITPGQGAQVFATENEPTKAKKAKEHWKEAGEEVEPWITLLEGDLRETLPDQMKKVDQIDMLLLDSMLTPILRSPFHHDLLSQYTIVWTPMALPALKAVQPKLRTGALIIADNTVMARSDYKDLFDYMDDPKNGFRHMTTPFKGGLEVIVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHX1</accession>
    <name>D4DHX1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RAB GTPase Ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019172.1">
        <property type="nucleotide sequence ID" value="XM_003019126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHX1"/>
    <dbReference type="GeneID" id="9577169"/>
    <dbReference type="KEGG" id="tve:TRV_06778"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23100" checksum="BBBFE9B425082300" modified="2010-05-18" version="1">MAARAPGGRTSARFAQFKLVLLGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDETTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQAASLDKAKSWVKELQRQANENIIIALAGNKLDLVNESPDKRAIETADAAAYAKEAGLLFFETSAKTSTNVRELFTAIAKKLPLDQAGPRNLRANPRPGVDLRPESANTQGGACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIG3</accession>
    <name>D4DIG3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018960.1">
        <property type="nucleotide sequence ID" value="XM_003018914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIG3"/>
    <dbReference type="GeneID" id="9582120"/>
    <dbReference type="KEGG" id="tve:TRV_06971"/>
    <dbReference type="HOGENOM" id="CLU_808848_0_0_1"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="343" mass="40266" checksum="972121FEE2ABFFE1" modified="2010-05-18" version="1">MNIPSRLEIKSRRRSPIESLPAELVHKIFFQCLEFNFPRASIRIAHTLSSSILYTWLIRLAFSSCNRSSRFDNIYGSHHFLPLDFFYFNHLERAKIQTEILKCRWLTASLLRKCQREYVEHVIREKRSHFVISPDEDQDILSNLDQYWQSINRFDPTPVGKRGKGDLVIRAHSLENDQPCKIAIWFGFGAFQIRDLNPVFQEIDIFRLPCAPPYPAEPCRMPDRLLTPPWTEDKLELLTLLSSDAYIDGGWPPDRSKAVLRKVIEDRELDVFRCLLSLHICGKQYRYPYPWPVSHNHFRVAARHAEPNKDPFLQLLFDKRKDSIPRDDASIMTLMEKYSCTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIG4</accession>
    <name>D4DIG4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06972</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018961.1">
        <property type="nucleotide sequence ID" value="XM_003018915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIG4"/>
    <dbReference type="GeneID" id="9582121"/>
    <dbReference type="KEGG" id="tve:TRV_06972"/>
    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="188" mass="21082" checksum="CA8F5D3FC6AA26B1" modified="2010-05-18" version="1">MAATRSAALKLDWAKVAQSLGLRGQTAASLQAFKKRNDDARRKVQVLSEAPQTVDFAHYRKVLKNQAIVDEIEQHFKNFKPVTYDVNRQLKAIEAFEAQAVKNAEETKGKVEMELESLSQTLDNIESARPFEDLTVVCSSYIPILLHLYQDDVAAAAPEIDRKTAQLVSKGIWMPPGYKEKYGDLAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ13</accession>
    <name>D4DJ13_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018818.1">
        <property type="nucleotide sequence ID" value="XM_003018772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ13"/>
    <dbReference type="GeneID" id="9581378"/>
    <dbReference type="KEGG" id="tve:TRV_07178"/>
    <dbReference type="HOGENOM" id="CLU_158083_0_0_1"/>
    <dbReference type="OrthoDB" id="4171847at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055903" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="96" mass="10281" checksum="697FAD049DC1BB00" modified="2010-05-18" version="1">MKFFAVLFLVPFLGGALAAPSPSEMIAEAPMQENSDMDASSQLLSVTAAQCPPSHPLYCRAYNFCCVRQAVSCCPRACCARGTTHCGSDGHCYRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ15</accession>
    <name>D4DJ15_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000419">
        <property type="protein sequence ID" value="EFE38154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018799.1">
        <property type="nucleotide sequence ID" value="XM_003018753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ15"/>
    <dbReference type="GeneID" id="9581200"/>
    <dbReference type="KEGG" id="tve:TRV_07180"/>
    <dbReference type="HOGENOM" id="CLU_2028411_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="122" mass="13384" checksum="44201FD1E4329462" modified="2010-05-18" version="1">MEGGPCPKSRANKPASCYFVAVVVVVAAAAAAGSSASPYKPRSRNRHAAHQPGIQSYRALRRKRAGMKLNGMFTQSSLKNKKKKRRGGMQKGCRRTSTSTTQKTKQNKLMSPGRRPSRQHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ36</accession>
    <name>D4DJ36_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase complex subunit (Hos4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018766.1">
        <property type="nucleotide sequence ID" value="XM_003018720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ36"/>
    <dbReference type="GeneID" id="9581167"/>
    <dbReference type="KEGG" id="tve:TRV_07201"/>
    <dbReference type="HOGENOM" id="CLU_002229_1_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="6">
        <location>
            <begin position="497"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1238"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="954"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1271" mass="141836" checksum="972DF6320D6B0E07" modified="2010-05-18" version="1">MSDVETASSLPETLNSSHQRANLHLAPKPALDVPRSATSANGDDGRPVAEDADVNDDAVSVKADSEAETIIQSGREELSPEKKKTYIRHVPGQNDKNGLDLASRKTPKFSQPGNWQLGKRKRPDHENDDSRSALRSNQSSRASSPVPALKQEKIDEPQALSSIQGPPSPSDDVSTERKPDDKSRKPESATIDTRDAPAGGRRLNHRSNSHGHESAGKSELYASRRQDRSHSPPIRSHKRVTSDSTHSPPLSNIQKRRKLPPQPLMDQSNHASEGRASPSSASSAGSPPPNPRNRRLTSCDTFPFSPVKQAQNKKLRDQNGRTRLARACAAQEIEAAKCRQAERPEDLNVPDNAGNTPLQIAALEGCAEIVKFLIEAGCDIHTKNIDRDTPLIDAVENGHLDVVKILLDAGANPRVGNAKGDEPYDLVPSDNENRHELRRVLAEAKCRGNKRRKSDDISGQGASSTKDPRSRGASAASSPDSPPHHAQSPPPQYNRRKTVRSEATRNDLLWTKPTFENLRLFAAKGDMAGVATILNILQKADTESLIAAAKGGHDEVLGLLLGMGNPDPDPEPLTNGNHRAGHDTPMLAAIGRGNIDVIKLLLDQPGFNPTRTDHKNRRFFELAEERRGDNWELERDLLKEAYDEYISAHPKAQKGESRSPRRPRDPLKVAKRPDRDSPSPASVVRKSSSKGVTSHRQNEEVSKEVKLQKERKRADGVASTKDRLATNKVSSREDSHGLMDERDHGQSDRKHKMPSDSRSPREATPHKHGEEPVKRRRLIAGRPPPDHAKRRPSVMSSDSFSGREDVSNKAGITEDSNDNGSRSEKRNSVLKRSRNSVSPKPSKPRNTENEEVREKHVKKRRILSSEHSSQPQTTVEGSKSKVENDTQTSKPRSVHRDSLGLKTEGSKAADHSISHSDKHRSTSRDPTATKIKRRASDSGVKAETPSESNAAAKAKHESHAEKEHAPTEAELERAAEKAQAKARKEAEAAKIAAEKAAIIEREKAEQEERRLEEERKKQEEERKQEEERKRKEIEQRRARQAEEEHQRRVEQERLRQARIRREQEEQEQRRRDVLPHRLRTAANLIGANDPRARSHEFLKRVMPILQATRDDLEPLCDPELKNEKWILNFYVALLLATNDLQLSQYPSWEKRVATPTQRSNIWDCSGPMLSNPQQLNPVKAGGNDYSRIYRETKPLYEKMEHVFWVKCSDFMDLVPHIPHLHGLNITFVSMHIDPEPSASLQDKSHIVNGDHSSHHPLINGTSEPNGVNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ52</accession>
    <name>D4DJ52_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2'-phosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018782.1">
        <property type="nucleotide sequence ID" value="XM_003018736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ52"/>
    <dbReference type="GeneID" id="9581179"/>
    <dbReference type="KEGG" id="tve:TRV_07218"/>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30669" checksum="E942C607B894ECDB" modified="2010-05-18" version="1">MQYRKLKGLKATLSDVLEAVSTSDKQRFGLLYIPGQPTSAEIKATEEATTGDGSSLSTATSQALAANDPDPNNYLIRARQGHSMKCIDAASLLTPLTLSENPPVSLPDTVVHGTYHATWPKILQSGGLRCMGRNHIHFASGPSISTILPNGRYGEVATPSTKGRGQDGVISGMRADAQILIYIDLKRALAAGCPFGLSENGVILSEGMSTDGTEDKKIGLEFFDIVVERKNGLGVLWENGELVKESPDWMLNAKAPAGKGGQKGQGGKGKGKAPRLKVERDTDHIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJR1</accession>
    <name>D4DJR1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018584.1">
        <property type="nucleotide sequence ID" value="XM_003018538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJR1"/>
    <dbReference type="ESTHER" id="trirc-f2sib3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9584513"/>
    <dbReference type="KEGG" id="tve:TRV_07429"/>
    <dbReference type="HOGENOM" id="CLU_006586_15_2_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="382" mass="41848" checksum="2B34FFC0E9F4ADE4" modified="2010-05-18" version="1">MGSGANVHSEDCLTLNLWTKGTAGRKRPVLVFFYGGRFTIGDTNTPFFDGQFFSEAEDVVVVTVNYRVGIFGFPGAPGLRQNLGLRDQRLAVEWLRDNAGAFGGDPSRITIFGQSSGALAVDAYSYAYRDDPIVAGLILHSGTIFSFPLNSRELAARNWHNASSLAGCGSAGDVLACMQSKSADDIRLAADKVPPPPNTSVARSQPVFQPGPDGELIFDDYESLASQGKFIQIPMILGHGDRESSFYNISASARGTVLTDEQWAQFVTDVFGCPAMKEADYRTQHNIPLWRYRYFADWVNTRLFPNSGAYHGVDLHMIFGNSQGVAGDPESPDQTILKRIMQRTWAAFAADPWAGLKRHGWPVYKKDDFVKPAAYDAHCPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJZ5</accession>
    <name>D4DJZ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein (CipA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018490.1">
        <property type="nucleotide sequence ID" value="XM_003018444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJZ5"/>
    <dbReference type="GeneID" id="9584419"/>
    <dbReference type="KEGG" id="tve:TRV_07504"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="36376" checksum="9745AB886221F701" modified="2010-05-18" version="1">MSYLKKVAIVGATGTIGQHIVREILKTQKHELTAITRSASNTVMPEGVNVAKVDYDNQSTLVSALRGQDVLIITMAASAPKDIHIKLVEAAAEADVPYIIPNGWGLDATHPVSDDAFIGPHQRAIYKRIEELGKSAWINFVCGFWYEFSLVGGPNAYGFDIDNRSVTFFDDGTARINTSTWDQTGRAVANFLSLKEKPENGEDERLTISGFRNTNVFISSFLVSQKDMFQSILRATGTKEEDWKITHEPSEQRYKSAVESFRQGDRGGFVRAMFTRMFYPEGSGNGSGAFEATNKLQNDLLNLPKEDIDGLTKVAIEDPEQFRRNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK17</accession>
    <name>D4DK17_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018438.1">
        <property type="nucleotide sequence ID" value="XM_003018392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK17"/>
    <dbReference type="GeneID" id="9584368"/>
    <dbReference type="KEGG" id="tve:TRV_07538"/>
    <dbReference type="HOGENOM" id="CLU_025630_1_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="349"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="628" mass="69754" checksum="51BC7269329C193C" modified="2010-05-18" version="1">MLSRKHRPAPSVKSLPISPPLPFPPAYYHQHGHEHQHHHHHHARDAKQAPDHAEIYPQMAPRDYPDYAAVPGPAPDVSLAVEQSYFDLRGQQQHHQHQHHQQHHLHQHQGRHEQYPFSPNDYSYEFNSYSAPRLPPSPPTSPPYVAAAPREDRDSYPASLASLPRSLKSAGHRRGTRSMGSATAVSQPSRLSRGGSATTDVGQASDVSIDLTDMLSDKLDEVINHMDMQVFSGRERDLYVDAGPAGPDAASKTSSGRSFLRSSSSASHKTNYFAKAYHYANSRLPPKLVPLNLFISTWPLLCLAAQSSQSAYNRPSSVERETHVEGDPYLGTKAMVIKSVALDHMNLIVFAVRGTTRSSFTDWATNMNAEPATPTGFLDDPGNLCHAGFLSVARKMVRPVAMRLEQLLAENPARSKFSLVITGHSAGGAVASLLYAHILSSTLRSELIYLRDRFKRIHCFTFGSPPVSLLPINKPSDPRYAKWLFYTFVNEGDPVCRADKPYIRSLINLYKSPAPSTQGSRSRSSTTSSKPSKLGFLKDRRESTDKSDFEPEVTWPIPSPTLTLPGCLIVLRGDKHNPRDKDVVEAYLTNNEQMAGVVFGDVMMHMMTLYERRIQLLATDAVTARAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK31</accession>
    <name>D4DK31_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018424.1">
        <property type="nucleotide sequence ID" value="XM_003018378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK31"/>
    <dbReference type="GeneID" id="9584353"/>
    <dbReference type="KEGG" id="tve:TRV_07552"/>
    <dbReference type="HOGENOM" id="CLU_064787_2_0_1"/>
    <dbReference type="OrthoDB" id="4206194at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="32208" checksum="B1301DB78A794EDC" modified="2010-05-18" version="1">MESSLESDNAHYIPKSDIEVLSQEIDNELGMYRIRTGNKIRYLTIEVDAFDEDTMCRPYLLIPELPSFPNAPWTKMDICRSNDGSLKVTTSDVKLQGVGFVWHPEKVEVLSLKRTRYYRHNVHEVIFNGAPAIAKIVRWEWELPRMENETAVYSFIYQDQCAHPEDPPIAPQVLAHLTEDGRVMGLLLEKVNGRFPGLDDLARCEEVVRRVHDIGIVHGDINRYNFLIDDETGNIRLVDFEHAKHLTEETARAELDSLPSELAEETGRGTTTEEKIAIFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK47</accession>
    <name>D4DK47_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC bile acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018414.1">
        <property type="nucleotide sequence ID" value="XM_003018368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584342"/>
    <dbReference type="KEGG" id="tve:TRV_07568"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="283"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="532"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="863"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1338" mass="147217" checksum="96C1E051E337608F" modified="2010-05-18" version="1">MARRTEAGTCHIFLVFFVTVVVISSLSVSCFPPSLPPFCPSVGVSGRSSRYLTVAGYCVLAAVSYLEHVRCVRPSTLLNVYLGVSTLLDLARTRSLFFIQDSHAVASISLAAFIVKSLAFILEATEKRHLLLAKWKDASPEATSGVINRSLFIWLNRLFINGFQTLLTVNTITPIDEELLAASEPTALLEKWENADKAKRYALFWVFFTHYKWYIMAGILPRLAYTGFSYSQPFLVQRVLDFTAQAPHAQTSNIAYSLVGGYAVVYIGLSTLRVGSTNEDNAEAITLMSADIDRIGYSMTLVHEVYAGFIEIAIALWQLHRLLGIAIVAPVGWIIGVPLAKAAADAQIPWLEAIETRLAATAKSLGSTKAIKMTGLADIVSSRITNLRLDEIRASLRHRVYSILVFVAAFASSELAPVWGFTAFILLAKKNNTGTLTEGVAFASLSLFELLNHPMTTIINGFENLQTVLNCFGRIQDYLNSQERVDYRIPQHDRRDSSVSGLSTPADTLKDTIILKEIQDPDSNTDAFVAFVEGASVGYTIGGDSPILKNLNFQIPRGEITMVFGAVGSGKSTLLKLLLGEMPCVSGLIRTGFSLAAYCPQSPWVTWGTVQSNIVGMSEWDKKWYDTVVSACALRTDLEELPNGDQTHIGTQGSRLSGGQKMRVSFARALYSRNSTMILDDVLTGLDRATERHMLDAIFGPNGLLKKLKSTVILATNSDNIIFLNENGEIARQGNLESFSAGDDIKQLANQCQTTTTSRPEPQLSEDVLHELEILEDPELESSRMTGDMKVYAYYAKNAGWWTISLYLLACCAFVVGVTFPSLWLQWWTNANDTRPNERIGYWLGVYSGLAFLAIFSATLSDRASTSFLTSTDAGTTVNRFSQDLELIDNDLPQSIDQAVFQFLSAIVSGVFVFIGAGYIAAAVPLCIIVLIGVQFFYLRTSRQLRLLDIEAKAPLFSQFLETVGGVACIRAYGWTQRYTERHYKVLNISQKPYYLLWCIQRWLTLVLDLLNAGLAVMLVAIATNVRSASTPFLGVALFNIVTFSSTLQTLVTAWTQLETALGAINRVRSYSQDVKDENLPNENGSVPDEWPESGAIAFNDVSASYDPSLGPVLKGVNLSINAGEKVAICGRTGSGKSSLVSCLLRMLEMDSGTILIDGIDISTISRQQVRSRLNTLPQEPFFLYGTVRDNVDPLQLADDEAVIGSLQDVGLWEFLEARGGLDEEVSEDKLSHGQRQLFCLARAVVKQGNILIMDEATSSVDAETDKVMEDVIREKFKGMTVIAIAHKLDTVLDYDRVVLLDKGEIIETGNPRELLAIPDSAFHKLYEKLATEGTHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKD9</accession>
    <name>D4DKD9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor Rba50, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018316.1">
        <property type="nucleotide sequence ID" value="XM_003018270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKD9"/>
    <dbReference type="GeneID" id="9580018"/>
    <dbReference type="KEGG" id="tve:TRV_07661"/>
    <dbReference type="HOGENOM" id="CLU_031074_1_0_1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="463" mass="50335" checksum="8DF1F01CE475F6F9" modified="2010-05-18" version="1">MAFRGERFHIDLSDDEDTPGRATAPTASLPSLSSFVSDIQERTPSAPTPPSAPTPKSTLTSTGFPAHRKRNKVSAFKRQREGAGAGAENDKPTVKENTEADEKRAIDEENRRRIEAMSEAEINAERAELTASLPASLIERLLRRANIEEDRQETQGEKRETHKQLEPSSSDTPDEKPKKSVSFDMPTSHQATVEEVKDDEREQTFTHPDDLPPSNPPPGLHPASQPPPPIHFPRPPPRSQPMPNLDPSSPSFLSDLQTHYFPDTPHSASSLSWLRSSDSDSDPSSAYHPSSTATSIAPAALRFSLKGAMLAPRTSLSIPPSKGLHHHAADPEAAGYTIPELAILSRSTVPAQRCLAWQVLGRVLYRLGKGEFGEQDTPLVNGLWSVVEREAVVAGMLSEAGADADIDVDGKKETSDGKLSTVQAKPGGIGRHASARAWATEAVWLWRRGGDGKRGLRRESEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE4</accession>
    <name>D4DKE4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018321.1">
        <property type="nucleotide sequence ID" value="XM_003018275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580023"/>
    <dbReference type="KEGG" id="tve:TRV_07666"/>
    <dbReference type="HOGENOM" id="CLU_000746_0_0_1"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1925"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2219" mass="244869" checksum="8B90D2A21E6BD58F" modified="2010-05-18" version="1">MSDWMPILARLEYIPILQKGLNDLRLRLSSNDTGYSVCWVWSTAVVSLVQSQAWRFATKSAFGSSRVKIAHARLLTLGRTTTSTITTTTTITKVEILARKRTLFCTQASPLYGYVYRIEGGFKAIFSWLRSMATITSLGLHKPSAFGYLVAESILPADAPEDTYTWRCYNSENENGGIIEEELLYTDKCVVWSRGGIVKRSFNFEVEGESIVEALFTYFPAGKSNAAKQTRTGAGLENSTAAQAGDQGHTAASVTSKQSRLNGKIRKKVVIQDQTDSSSVPGLGTLENENTTESSRALVVVLKSQVHIFFISGDSHVVPLPFELDSIWPTPNGLLFQRKLPEKHEAPVPPAPPNSFVSSQPRHPTSRHSAASFRLSGGTGNRSLLALSPSQPSKLLLKTEKDDSAPRVFSLLDPHSEMGLVAVTSSPLDDDELHKRTDILSQTEELLYVSPTSEIPLGVLTKGASPLILLVTLNPKSGLHNIWVAKYRPRESPISSQNQRRKSSNTRSKRRSSHFDITTGTSTPVGPGPSSFRESFGGPGHGRNASQQLNLEGKQEGAADLASHLGQEFEDVGVTSKASRRVSSLLARSDLMANNDRSTFSDLAGSQLKSSFHGGSRRGESFGGTGPRLSQSFNRRGSLPPGTASVYSNGSSFLDAPVDKLLESLNNGGDFDGFESMGIKETVSNLPREVILSKIASVPSGIISTNALPYSQKTCPFEVFTLASSDESTLKDPESIPLAVCILNRNSKDLIVVTLSAQNLGSQARQYENGDNDISTYKVRALNVRHGSNVLDCCKLADRGVSRMLVLSSTSDGRGELTLQAPWSTLVRVELPDSLVLYEPSNISMELTPSNIREEGLGRVLCKTPLNMRRLTQSTAGGKVDITDEQNRKHRIQIQLQPFNSLVRRILSLCRYVLRHAERAGDGVHIGWWQALRWLRARDVREENLEWTALVVILFSMAVYFIDDITTEPKVLPKKKKRGALMRSSTGSSIDLTDWHSMVDQESGSAGICASWMSTTAWDWIREEHTKNSVERTQSHRTIDDHKAETQPNDKNTYITRCAQLARDFLSSPQGEAATGGDGYLTIAISRDQGTRRTALGTILVGMHLLREELKLSVANTDNSRSEKGLLLPVLAQIGGWLGWDSWTWKEGSYYGTETASIDAWTFEDTRITGLDLPPEPFTPPSIFSFVENTLQRTPSSFLTLMDVVSSSTIAPGSGKIWDQAVNLTPRSLALTGFLSEVRNKQSAPERMALLLRWGITSSLIDTLPDGISTPLHEAIFNCQGDPPLSWGSSLLELVDREDLFLSTSSETPQLPASRSQFIQPHDAHRDVRSIGNSVLDSSSTNSFEISAEADRHWITKLIFRDDRRYFEAARILNQMKAPTAECTPEPDWSESDLLEAQKELVQLVTLRTLSIPAGRAMLCFDGRVPLLTEKLPIPSFSLQCVMKPSNVTISADRSAFVEEKACWAFFHNGVSTGLAISKSAKGIDTSWILYNKPNELTNRHAGFLLALGLNGHLKTLAKWVAFKYLTPKHTMTSIGLLLGLSVSYLGTMDTLITRLLSVHVTRMLPPGAAELNLSPLTQTTGIMGIGLLYCNSQHRRMSEVMLSEIEHMEEEETSVSQEPLRYEGYRLAAGFALGFVNLGKGSDLQGLQDMRIVERLLALAVGTKEVNLVHILDKAAAGATVAIAIIFMKTNDKALAQKIDIPDTEVQFDYVRPDIFLLRTLARYLIMWDSIKASQKWIQKSLPSFYRHKYRLSAIKRLTTDDMPYFNIVAGLCFALGLRFAGSGSIEARDLLVAHLDQFIRICRISALNYDAKLTQNSVRNCQDIVALSAAAVMAGSGDLVTLRRLRSLHGRVDGDTHYGSHMATHMALGMLFLGGGTYTLGTSNIAVASLLCSLYPIFPTSVLDNNCHLQAFRHLWVLAAEPRCLIPRDIDTRRPVTIPVSLTLSTGEVKTATAPCLLPELDEVSSIKIASADHWTITLDFTSNESLRNKFRDGDQSIYLRRRANHHDSERSVFSTTIAGLSDAQDIPPPAAIPRNTRPFYAMPPASLHASLQPSEKGPGEARMPPRHIWDFIFDLPAFSSLDMSERMAVLPQIPFHESLKLLSCGKKRNRTSPPSWLRPTAVDTRLVLNRTMRNLISAAACHGVSEEVVRDRLWQLRLLFAWIDGAKYSSNDDGAGHDKDGISISMSRWLKQEVIEDARWKIWRIQSGDTSVIDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKP3</accession>
    <name>D4DKP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000478">
        <property type="protein sequence ID" value="EFE37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018220.1">
        <property type="nucleotide sequence ID" value="XM_003018174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKP3"/>
    <dbReference type="GeneID" id="9579596"/>
    <dbReference type="KEGG" id="tve:TRV_07765"/>
    <dbReference type="HOGENOM" id="CLU_066049_0_0_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="348" mass="39281" checksum="B273126D955CABDA" modified="2010-05-18" version="1">MDLDLCFTVVQPAPDGYESAVPLVLIHDGGGTSVNYYYLHSLDRAVYAIQNPSFYSGEPWEDGIPEMGATYARLIRSHVPAGPILLGGWSLGGMISLEIASIFSRQSSELRVLGIVMIDSVYPLAPKPAGRTIVPHKLQFGKYTKPETQRLSSNCMAQAVQMAQTWTMPVWRGCSDETEYNRRAAFEKELSQKMKSKHPESEEHNEISMRDLAALPQAILLRCNETVPVSTPEDPTAMCRVDVARDSEKLGWEQYGYDFISAVLQIPGHHFNIFSDEYLDDLTSRIKQKPKDIEYKWQIGKVISLFYDIFNNDRTAGMLPSRQIEELSTSPPPTLEWQYLNQKPQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL06</accession>
    <name>D4DL06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="ACYE01000486">
        <property type="protein sequence ID" value="EFE37467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018112.1">
        <property type="nucleotide sequence ID" value="XM_003018066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL06"/>
    <dbReference type="GeneID" id="9579321"/>
    <dbReference type="KEGG" id="tve:TRV_07880"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="27109" checksum="049B82955055B777" modified="2010-05-18" version="1">MARKFFVGGNFKMNGTSQSITDIITNLNNAKLDANTEVVISPPAIYLLLARSQADDKIGVAAQNVFDKPNGAFTGELSVDQLKDSKISWTLTGHSERRVILKEDDDFVARKTKAAVEGGLNVIVCIGESLEEREANKTVEVVTRQLQAVADKVTEQQWSRIVIAYEPIWAIGTGKVATTEQAQEVHASIREWLCKTVSPAVSEATRVIYGGSVNEKNCTELAKQKDVDGFLVGGASLKPAFVDIINSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL13</accession>
    <name>D4DL13_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras guanine-nucleotide exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000489">
        <property type="protein sequence ID" value="EFE37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018096.1">
        <property type="nucleotide sequence ID" value="XM_003018050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL13"/>
    <dbReference type="GeneID" id="9579314"/>
    <dbReference type="KEGG" id="tve:TRV_07887"/>
    <dbReference type="HOGENOM" id="CLU_002116_1_0_1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055647" description="Ras guanine-nucleotide exchange protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="768"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1234" mass="136332" checksum="9B44308BDE3407D0" modified="2010-05-18" version="1" fragment="single">RAPRLALLLLAAHCSYSAAWIMESSAEYVAPLNLSTAATTTTAATTTTTTTTTTTTTTSASATATTSPLSTAADDAGSLAVATNNRLITALNAQLRMTPPLTPHSSREEMVDRSGQGRSLFHNYLRAFYPFHPDGPISSSTVTLPLDQGDVILVHSVHTNGWADGTLLETGARGWLPTNYCEAYDPQQMHPLLKALMDFWDVIRGGSGSTLHQFSNQDYMRGMIAGVRFLLEKSECLTRDCRLVKRVDGLRRNRKALLSDLSSLVKLAKQLQDIANGRHFETCLDNIFDLMLLKAFRIVTRGVRFLDVWSEEVGLVRALDHLDNTNSSNTIDTMFKGPLTPPVDGSFSFSSQRATSSIGTPTSSSSWRGSLGDRSLLNSTTIVSQKSGRETPQRPASIRIKRPSLSHRISYSGHTTKNPNLASGRLTAAHDGFLGVLGSFIGLHLQSPSSTELIVTTQEAVQSCKTLLSVVEEVWERDLHRSFLLERSKNTMYDHIAELVNATQNTFRTPINPDDETIFVPGDGKRLVDAATDCVRGAGDCVSRARTVLEQIGDFELENIGLGITMPSTEDITTPTNHKVLPERTDEVVSATVTKPDDELSMRPLPLRIPDGSVSSISLTPSSFTDASTLRTPTSPFDESFSSAFTAITDFSDSFNSNSEHDLSKSFHAYSPTKSTNDVPWQQDPAIYIPLPQGNDMDLTLEPTETESTLVPETPTRPVSPASATHKSPKSPKSPMKEDSQTEVGSTSSDGDEDSLLEKTYAHELMFKDGQVTGGSLRALVEKLTCHESTPDALFVSTFYLTFRHFTTPVEFAEVLIDRYDYIGETPRAGGPVRLRVYNVFKGWLEAHWRHDVDDIALPTILNFARTKLLITLPTAGKRLIDLVEKVSSLQGPVVPRLISTVGKTNTSIAQYVSPDQPLPQPNMTKSQLNLLKQWKNGGANVSILDFDPLEIASQITIKESQIFCSILPEELLSTEWMKKTGSLAVNVRAMSTLSTDIANLVADSILQLEEPKKRAVIVKRWVKIAAKCLELNNYGTLMAIICSLNSSTISRLKRTWEIVPAKTKNLLESLREIVDVSRNYAVLRQRLQNHVPPCLPFVGTYLTDLTFVDHGNQDTRTLAGDESSIEVINFDKHMKTAKIISELQRFQIPYRLREVPELQTWIQDQLVRVRSAGDKSFQQYYRRSLVLEPRERAVTPRGSPTEPSPSLFAKENTKEKFDFLAWTHGSKLKVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL84</accession>
    <name>D4DL84_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000495">
        <property type="protein sequence ID" value="EFE37389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018034.1">
        <property type="nucleotide sequence ID" value="XM_003017988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL84"/>
    <dbReference type="GeneID" id="9579160"/>
    <dbReference type="KEGG" id="tve:TRV_07958"/>
    <dbReference type="HOGENOM" id="CLU_172028_0_0_1"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="9014" checksum="441C9794718F5CDD" modified="2010-05-18" version="1">MKCVVTKLKEAGKSEDEIKEFQTGAQAAAKTILANFKDYETYTGESMNPDGMIVLLNYREDGITPYFTFWKHGLKEMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL96</accession>
    <name>D4DL96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="ACYE01000497">
        <property type="protein sequence ID" value="EFE37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018018.1">
        <property type="nucleotide sequence ID" value="XM_003017972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL96"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="9579150"/>
    <dbReference type="KEGG" id="tve:TRV_07970"/>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_1"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="400"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="856" mass="93118" checksum="9CC326C83F26CF3C" modified="2010-05-18" version="1">MRLVPRELDKLTISQLGFLAQRRLARGVRLNHAEATALISSNLHELIRDGNHTVADLMAIGKTMLGRRHVLPSVVSSLTQLQVEGTFVCGSYLVTVHNPICSDDGDLEKALYGSFLPVPPKDLFPDPDPEEYLPERMPGAVVVVKDSRIELSPGRRRIKLRVTSKGDRPIQVGSHYHFIETNPQLEFDRAQAYGFRLDIPAGASHRFEPGESKTVQLVEIAGHKVIKGGNFLATGEVDHGRRDRILSRIAQAGFMHTPEPMADASLVKPYTMTREAYARTFGPTTGDLIKLAATDLWVKVEKDLTTYGDECTFGGGKSLREGMGQATGRHAHEVLDSCVTNAVILDWSGIYKADIGIKDGIIVGIGKAGNPDVMDGITPGMVIGSSTDIIAAERMIVTAGGIDTHVHFICPQQVDEALSSGITTMLGGGTGPSEGSNATTCTPSPNSIRQMIQSSDGFPMNFAFTGKGNDSEPRGLRDQIRAGAAGLKIHEDWGATPAAIDSCLSVCDELDVQCLIHTDTLNESGFVEQTIKALKGRVIHTYHTEGAGGGHAPDIISVCEHPNVLPSSTNPSRPYTLNTLDEHLDMVMVCHHLSKDIPEDVAFAESRIRAETIAAEDVLHDIGAISMMSSDSQAMGRCGEVVLRTWHTAHKNKLQRGVLPEDEGTGCDNFRAKRYVSKYTINPAIAQGMSHVIGSVEVGKVADLVLWKFAQFGVKPNLILKSGMIARAQMVFTYPFSTSSQFSHHLTILQGDANGSIPTIEPILSRPMWASCLPNTSIIFVSQSSVDDGVIDTYDIKKRVEPVKNCRNIGKEDMKFNDTMPKMHVDPESYTVEANGMVCDADPIDTLPLCQDYFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLD0</accession>
    <name>D4DLD0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018000.1">
        <property type="nucleotide sequence ID" value="XM_003017954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLD0"/>
    <dbReference type="GeneID" id="9579128"/>
    <dbReference type="KEGG" id="tve:TRV_08004"/>
    <dbReference type="HOGENOM" id="CLU_002590_0_0_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="486"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="778" mass="87136" checksum="F6E7C1DFC22E8253" modified="2010-05-18" version="1">MALHPPQHAPSAKPPPLRVDSSSVRSMSNGSVDYRPTPKTPGSKITSFFGWKTNAGSASPGNESCATEISDSALSPMPSPMTSVNPSTAASTVFTNTHRPQDSFSSVPKMAGRSQTMPMDASVTSRLADMEHELREISSELAGSIRREMELEDIVERMQLESSESDRRGSEYYFSDSGQGSSVKDLSINGSTKTEDIEKLKRNYEQERAQLKIDLSQKWQEERSRRQVAESHVQLLESQISQFRREKVEASNAAGKSKELEAALEDTRRRLTEERQLKDNMEDLLTGMRVELEQQKLERDQLQAQMQQDMQNLRNENSLLSQSRKAPPEMPQSPRIDSIAEEAIGIGIGLSNNRASGGLSRSNSLARIPPVRNGVARSGSLSRPTSMIVKGPEFHESLVNQMKDVETQRDALHQTVKSLLERQSYQARQHEKRLRLMELELYRARQANSPRKRSYERDVKNLREEINLLRRRADDALDQKWQCEKGLAGLKMDLDRAEQETSSLRALLQDYDIPVPHMDGTDTNGMTDFHTTASSLEEMYAQLKIERENAEPGSPIPNEDLENEIKKQVASNASLRARLADAISQGEREQKLSATKINEMQSRLKSLEEMLMLAQQRSEEEVGKHEQEVSALMENHNALLLRAKDGVRSPMMLSPVLPNSPFPTSRSPRLTKTTSGEAQGLNQVAQIENLESKVRALEQALRDADAEMGEVVSRMNTAQMQVAELQSDSTSPDKKATSSSTAMLIILNKYAKHTTAFRHNTTAITTAHKRAMKSTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLE8</accession>
    <name>D4DLE8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017971.1">
        <property type="nucleotide sequence ID" value="XM_003017925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLE8"/>
    <dbReference type="GeneID" id="9579849"/>
    <dbReference type="KEGG" id="tve:TRV_08022"/>
    <dbReference type="HOGENOM" id="CLU_1165582_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="238" mass="27618" checksum="D0208030145F003F" modified="2010-05-18" version="1">MEAPSSTKQTDAPFRFLDLPFEIRHEIYSYCMPYHTHFEEIRYFRARASFPQPAVKKSNVKNKNALLRVSKQISEECLNILYGKNRFYITLNASKRCLLANRITTENRTRIRDVVVIVRHMGPAYGLPPPVPADGLWSSLLPGLRQLKIIAEQPVQSPNSPFDPAFDEKVRSWVKWFGLLMECFAKYLTSYTVVEVDENGKDVTTELVRQHLTHSYRVVRDDIHGDFIFQRGRFAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ88</accession>
    <name>D4CZ88_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025711.1">
        <property type="nucleotide sequence ID" value="XM_003025665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ88"/>
    <dbReference type="GeneID" id="9581954"/>
    <dbReference type="KEGG" id="tve:TRV_00125"/>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044337874" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="180"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE45100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="31014" checksum="B23077BCA70136C5" modified="2010-05-18" version="1">MRLFAALQLGLLALAAPGLCASSGWGFADGTLSIHQKGAGIGGAEKHKLSQDKPLAKTITLNDASTLKLLLTIQEDEVAARPHQAFLTLREIDSGLDISYPLNVKGNGKAVVELNQKDLPVQFLTAKTPVEASLLIASFGSSSGYYKSVFKLSVEHKPDTPLSTSKALRYGKLEEIHHTFREDPRSPPMIVSLFFVLAVLATLPLLAISWLYMGANANHLSVALKSAPLPHIVFVGSIVGLELTFFMYYTSWNLFQTLPVAAAIGVVSVISGSRALGEVQQRRLAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZB6</accession>
    <name>D4CZB6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor (Azf1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000009">
        <property type="protein sequence ID" value="EFE45058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025669.1">
        <property type="nucleotide sequence ID" value="XM_003025623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZB6"/>
    <dbReference type="GeneID" id="9581907"/>
    <dbReference type="KEGG" id="tve:TRV_00157"/>
    <dbReference type="HOGENOM" id="CLU_028814_1_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="37430" checksum="F948E04F25E8EF92" modified="2010-05-18" version="1">MHGGAPEWAQPNYGAPMSQEQAQQIQQPGYAPHQQTRGASKQKSRRKYECTLPDCRKNFTQKTHLDIHMRAHTGDKPFTHERRHTGEKPYSCDICHKRFAQRGNVRAHKITHDQAKPFTCRLDDCGKQFTQLGNLKSHQNKFHAQTLRNLTVRFAMITEPDRMSPQDAELWEYFAMLYKNSNKGIKGRGKDRRVSSTAKTRANSTKTTTSDAAANNIISSAPAPAPAPPSSSRMPAHQLPLGSEEEAKLMRERSYHRETEHSYGYLEYIKEGLEHLAEVLPHQKKYDEKALGSANSSLFFFFFCSCQQKGRTNAFLFLRSHPTARGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZL4</accession>
    <name>D4CZL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025616.1">
        <property type="nucleotide sequence ID" value="XM_003025570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZL4"/>
    <dbReference type="GeneID" id="9581854"/>
    <dbReference type="KEGG" id="tve:TRV_00256"/>
    <dbReference type="HOGENOM" id="CLU_038073_0_0_1"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55849" checksum="E9A2142780627ED3" modified="2010-05-18" version="1">MSRSRNEGIDADYNDDDYVAQLLAKDARDCSRRYSALGVYGPSKRSINGAPKPNTRFLKHILRETDSHNENLKRKEEEEARHRMRTLLDGRGKPSRSSRSDGRDDREHKRRRVESPERRGQNGVRPHHRDRDGKSRIRKGEKEYRHSDGDGDTISRARKRRHLEDRPDKEDTVRESGPSGHDRKGERDHHRRHQRAQELSKYEYDHPPRDQRENSSPRQSRGDRRAHDRHERSRSRSKSPSRTHRQRRRSRNREEKIGKHKHVEDKGGKLRADTHASADKKPPPLPPQTCAEDVRSRHMSPNDGSSTYSDDSDPLSDLIGPAPPTALADNSQPIQSRGRGVYRTTNSSNIDAHFSSNYDPSLDIHLEDDNAAKDDHPGHIRPVPGLLNPKEADKHANDDWDMALEALRDREIWKRKGAERLREAGFDDKVVEKWEANKSFAGLGSNDYKEIESVRWTKKGESREWDRGKFVDENGHISVKAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZM9</accession>
    <name>D4CZM9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025509.1">
        <property type="nucleotide sequence ID" value="XM_003025463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZM9"/>
    <dbReference type="GeneID" id="9581746"/>
    <dbReference type="KEGG" id="tve:TRV_00271"/>
    <dbReference type="HOGENOM" id="CLU_021555_3_1_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62000" checksum="DF6E19E0B9B897A2" modified="2010-05-18" version="1">MVSSSFLQRLEVPHPPGQPRPTWLLNNDIKPIEKARRTWSWYEYFSFWCVGAFNITNFQLGSALLATGLNWWQTTVATLIGHILASLLIIITSYPGLEYQISFPVAMRISWAPFSDSLSFFSPGFYGSAFVVLNRILLSIVWFGVQSWQGGQMAYVCIRAIWPSIDKIPNTIPASTGMTLPMFVGFIVFSLIQVPFLILGPGRLRYMLHVGAIGGFICQLVLVSWAGGTKGPQGFGEILDSTNKLSGSDAGWMFVLGIGSTMSSITAGTLSIGDYARFARKRSDGIWSQGMGAFPAWIANVIGMLTIAATQKRYGAALWSVASLLMAIQDADPSSKTRVGVFFCAFVFGITQLVLNISGNSFCGGTDMSALLPKYINIRRGQALTAILGTVINPWYLLSGALVFISVLSSYVVFLQPFVGIAAAHYFVIQKRRLKVPELYITGKQSIYWYDFGVNWRTVLAWLVGVTPHMPGMVHSVNPKLPVTAGASHLYYIASITGFFIPLDYLVPVKVQKDFIQSVSVREAQDIASEMAESNEKSAEGAARLSPDRESSVEHKIPEANSHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZQ5</accession>
    <name>D4CZQ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate transporter/malic acid transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025535.1">
        <property type="nucleotide sequence ID" value="XM_003025489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZQ5"/>
    <dbReference type="GeneID" id="9581772"/>
    <dbReference type="KEGG" id="tve:TRV_00297"/>
    <dbReference type="HOGENOM" id="CLU_030057_2_1_1"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="52955" checksum="EC590DF5562F7BAF" modified="2010-05-18" version="1">MAIPRYLRRPGDEGYRTPTIEDTEKNLSLSFVFPSQPPTPRCPTPPVLSQFRQRPPLAHNLPKIHGDGDGNGTITPVQLLESQLPSLSWRERIQHLTWSFFTLTMATGGLANVIHSIPVEARWLEIIGLVIFLVNLAFFVAISTLMCVRFYLYPYTFKASFLHPTESLFIPSVIVSFGTILINVAQYGPSHAGEWLAHATVVLFWFDAALAVILSAGIYLILWSTQTFTIAKMTPIWIFPAYPMLIIGPHAGILSASVPQNHALRIIIGGWTIQGIGFLVSLMVYSAFIYRLMTQKLPNESLRPGMFVSVGPSAFTVAGIISMAENAARSLPADFMGDGDLTAKIIYVVSNFAALWLWGLAVFFFFIAVFAHWTPARRGRMTFSMTWFSFVFPNTALTTATFAVGRAFNSNGIQIVGYALTILLFITYFFVFFMMVRAIRGRQILWPQKGEDKDEGGFKIKEHKPDANGVLPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZX8</accession>
    <name>D4CZX8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025432.1">
        <property type="nucleotide sequence ID" value="XM_003025386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZX8"/>
    <dbReference type="GeneID" id="9581688"/>
    <dbReference type="KEGG" id="tve:TRV_00372"/>
    <dbReference type="HOGENOM" id="CLU_309976_0_0_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055868" description="FAD-binding PCMH-type domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="950" mass="103881" checksum="0CB2B5D7A138276D" modified="2010-05-18" version="1">MKFFSSGFSCALAVIYATAVTASPYSNISSVSDFINLLDVSNATGAKIADTLQDLDTKKIRSLSTQGKNSLGCQVSRLVFGRDFLDSRSSNYDKRVEVNWSAACWLRPRCIIQPRSTEDVAKAMKIVTFLATKFSVRSGGNNPNPRYSSIDNEGILIEMINLNEITLSDDGSVAHLGPGNLFRSVYSRLAEAGRTVVGPRVGDVAVGGYFLGGGISFFSSMYGIGADNILNYEVVLPDATITNANATHNRELWWALKGSGTNYGIVTRYDVKTVPNSKVWFEAPLYSPEQSKLLPEAIRKYAAAAENDPHAAIIMYITPQSGLVGMVYGKPTPRPDVYKSFYDIPATQNYINSTTGTWADMYNAFTGVPPAAKRKMIATIACKWDAKVLEESFATYLDISARVADEFGAVLSYSSQPITTAAVKYGSENGGNPMGLEEISQNWFVSTIEYADSAHDEAALKAIQALGESVKSAAVSRGAHLSFLFMNDANYEQDVLSSYGQNNLARLRAMSRKGCFKSSKAAEVNHISICEKHMFMAIQAQGSITANLVLPGLRLNWACSSILNNLKSTVSSSQLSFVLHPPSTDPSCSLALSHTMSIDPSQAAPLNPGDLGRGPVIMGVTWALTGVSLIIVSTRVYFRWKRPRTLAWDDAFIVAAMGFVSEAYRWGLGKRDENLAIPELIMVIKWLWISTTPAIVVSILARISAALMLIRIFGGRAWFKWFLIYFTALQTVAGLVNLIACWTQASPIQAVWDPRVTATRKMSPQFQNITANVSQALFALSDLSYVLLPTIFIWKLNMPLRQKVGLCITMSLSLISMVGAILKAVTSNTVVTQYDSSIVILWSGIEQALVIFINCVPALHKVFLSELLWVRKLSSSIVKFVSLDRNGRGSSSAYSRSNQGVDSRSEAGSWTRRKASAQEEGRDSSSTSDVTYAVHMHELDTHKTRGDYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D029</accession>
    <name>D4D029_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP transcription factor (LziP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025362.1">
        <property type="nucleotide sequence ID" value="XM_003025316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D029"/>
    <dbReference type="GeneID" id="9581598"/>
    <dbReference type="KEGG" id="tve:TRV_00423"/>
    <dbReference type="HOGENOM" id="CLU_020078_1_1_1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="406"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="724" mass="79716" checksum="5932B2EBE5A3FFF0" modified="2010-05-18" version="1">MDAQPPFLSLPAGALFGPLRVLLSPSPTSTSTSTSTTTLFSITSILSTISTALDIGYKDHKTDTETAQLTAETVIMAAMGEMLPTLSPLTSQPQSYDVAADMDSFLNLEPTMYPSPSVSPANSDSKTASKHGFVQHQQQQPQQQPQQQQQQQQQSPQQPQYTAPSHQYTHYTQQTGLPPGGLANTIALNNYGFDPMGMVHPVDGVYGRMGQPMNSLSTLPLKDSTEMDLDENLADSDAYIVPSQANKTQFVDPSALGAQEIPLSAAANQTRRVYPGIHQQQAARAKAALQQRQEMLQRQQQQQQQQQQQHQHQHHQQPLHQQQSSQQRQTPEAHQNRPQSKFNRNMDPRVQEKISHILQQMRQNSVSSLEETEQTSSLPQPTKYKKDEQDMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYIGQLEGEVAAKTNEANELRQKNNALALENARLTDFTRMLLSSSHFAPLLSEISANGLPPNLGSQSQPQVQTHTTPAPQLPSQPTGTKEAGIEQPHQEVSVPNLQTGLPVVPEQAFDFASIDLNDQGWNSGIDFNFTNPSVFAVVDVPTCPSLDMEAITGKSSNSVGPVTSDETKEVIPSIDTVSFGIDNSEAPKKEASIPVSAADLDIDENDPCFALYLDQPCTPPTSDQTSDKVFTTVKLDDISSKIELVVEGSSSNNTSDEISATTNRDFERLCANMEASCHYIFQATSHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0F3</accession>
    <name>D4D0F3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000030">
        <property type="protein sequence ID" value="EFE44677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025288.1">
        <property type="nucleotide sequence ID" value="XM_003025242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0F3"/>
    <dbReference type="GeneID" id="9582899"/>
    <dbReference type="KEGG" id="tve:TRV_00548"/>
    <dbReference type="HOGENOM" id="CLU_020849_0_0_1"/>
    <dbReference type="OrthoDB" id="4174440at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="587" mass="61335" checksum="E194EB06F38A12A6" modified="2010-05-18" version="1" fragment="single">MAKKRKGKKGATNRLPANSVVPDIDNGSSSNLPRGDGSSALPENVEPKLSFKYQTYDWHTGQFKDCPISSLYSSPPSDDGNGEPTADAEPKKDVPLDQQPQDAPAADVDAGKDAPGTSPGITENETSEETQKTAEEEKPNEGTPSTEDRPGEETAKEAPATEDPPSEGAPVEENAVLEEAPVKEEPATEAPATENPPSEETSTEEKAIPEEAPAKEEPTTEAPAAENPPSEEVLSEEKPAAEETAVEQEPVIETPASEGPSAKEAPAPEENTPAEAAPAEENSVSGETQTEQEPPAKVPAVEESPAEETSAPGELPAEETPIDEAPAAEETPTADEVEKEPAEEALTKEISTEEDPTEKPAAAEEPSVEETCPEEAPVGKESPVEESPAKEVPTETSTAEASSAVEEPPAEEAPTGGAPSEETAMEETPVEGTPAPEEAQPREESPVEKTASEEAAPPEEPPAAEESPTKEDQAPKEVPATEEPSAGKENPAEEGPAPELSEEGEKLVEVTPEVPIEGEAADTDKVGIEEENKGTAEGGKNDTADAAPDTRNVKEGENAPDIDVPKPSNDHAEVTTEEKEETSVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D175</accession>
    <name>D4D175_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025018.1">
        <property type="nucleotide sequence ID" value="XM_003024972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D175"/>
    <dbReference type="GeneID" id="9580510"/>
    <dbReference type="KEGG" id="tve:TRV_00823"/>
    <dbReference type="HOGENOM" id="CLU_079100_0_0_1"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="27534" checksum="5FACB80A351E4FD3" modified="2010-05-18" version="1">MEFSVMQLLLELLQRAGISVCIVGELALNYYNAPRIVHDLELCVREDDLTTAASIFQSTEILDIAPETEYNIYTEYKKGFPRFRSRSEPKFYIVLFTDRYYRLSPLEQNIISPEEHDEFQGTYSKELLDTVPAHQIATLPLPRFAPLLRGLCTIYIETREVTAAIAAEMLVDGMDIDEHWCHRHFDPSHQAVLNFALNLVRGKASRIADFSMNEVTCFIVDKHELQNLRGVPGFSRSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K0</accession>
    <name>D4D1K0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024876.1">
        <property type="nucleotide sequence ID" value="XM_003024830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K0"/>
    <dbReference type="GeneID" id="9580367"/>
    <dbReference type="KEGG" id="tve:TRV_00951"/>
    <dbReference type="HOGENOM" id="CLU_550035_0_0_1"/>
    <dbReference type="OrthoDB" id="4178675at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="503" mass="53864" checksum="6E0F613C8BA4A679" modified="2010-05-18" version="1">MKAFFARSRHSLVPQQQQQQQQQQGSQQDSNEHSPPSYPPQASGAYLAPPPPYSETVETPSSGSGAAVVETINTDTTASASGSQTAAGLASKTRRPLRDDEAALHLAVKNNHVSVVRALIKAGVDVSCADSSGWTPLQKVVSHHQEKAVEAVNALLIAGADVLAVNDEGMTALGVAASKNLQGISDILLKAGAEINPSDPKAVPWSPYLLAAWSGHLELMKFYLNWGADAHAVNDGGWNALHVAARRNHFPVLRFVLSTKKPLSVKSVIYDKRTALHIAAKYNNLEIARFLINSGTPVHARNESGYTALHAAAGEGHDEIALLLIESGSDVNAKADDDWTPLAMTAYHNKESTARLLVEKGKANIEIMNSSGWTPLLLAARWGYVGIVKYLIGLGANLNVVSTLNRTPLHMAALHQHEEIARMLVGLDIDVSAADKDGWMPLHLAARNGAEAIVSLLLESGADPHAEFKPDGVSSSPLQLAAENGHEKVVEMILQARKRVQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L6</accession>
    <name>D4D1L6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024892.1">
        <property type="nucleotide sequence ID" value="XM_003024846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L6"/>
    <dbReference type="GeneID" id="9580383"/>
    <dbReference type="KEGG" id="tve:TRV_00967"/>
    <dbReference type="HOGENOM" id="CLU_006836_1_0_1"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000096">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120894" checksum="9121107B7BF733CF" modified="2010-05-18" version="1">MVKPDVSRDYYADLGVGPNADQEEIKKQFRKLALKYHPDRNPGKEAEYNSKFQAIQAAHEILVDPQLRLKYDTGRLRAGYGKLYGPSRTATPTRQAPPQAASNPFRKSQPSYSSHQYGKSANAYPGAYPPPPPSSGAQRYASYAKAGAQKFDKVYEESRARAEAFQGFQDMKNKQPQPQMPGGWTSFDPRTGRAQEKPASKPRASHQKGQSAYHAFAEEARKAAEPPTPERSKSTKAKNGFAPRTAGGDEPMAKCATSYYNLRGERNRDSDPMSYFFSTAPSPTAKKPQPYDDLSDPPTPNLHRTSSKYATSGGEKTYVPKAGINRSSSVREETASRPQTNPPSPINSATNSNRRHSASPKLKPNRKSTFSASSASSTTSSETDDTDEVILNPRPKAVPRSRRAHNGSAWKANNKPSATGESPFGWAMGPNSWLFTEINGSPSQPPSSSNKWNWHADDQHEGYGPSTFGNNAPFPSETRRESSMGRTIPPMPNVSSFRATSTEEQRPSAATMYDFIPISTPTPTSTPKTTPKNTTPTPKPSARNWSEIWGFSPKPGVSANSHVPPLWAYPANILPASFTTPQMSKEMEEEDGETENEDEVGGAAAFNTDDAGRTPRKTFSEYREFPSSTPLRAEANCSTTIHSFDQPDSSNPNAQNEGLARHAKSKSKSYESFNSGFSPSEWNFAFSNNAQFFAPTQGDSLGGTQNKFGSRPRSRSRPTTSQSNESPQKSTNNPFDFKDTKPDARPPLFKTTTFTAEQLPDSLNEKTWTIPTAQDMFFGGQKNQTDSKKPATEPKPVRISSEAEEEEATFSPHQIFGKKSTKRESMDMADEMDVDEELPTVNVANAQAGNNTTNNKPKFSMGPAFMPSNKPGGKPELFNLAKLGLVNPFTASNSKGIADLKDLNSSLPFESKAASSEKPSQRPIHPRDLSLPKPPKAPTPPAMIGAPPMPRTAMEKQSLPQTPWDIYMVQMQAYMREWNNFNRTMLAHFNERQHLVETAMAPGWMRAVGDSSRVKLDGSNGDSADAEEDLLAGKGKTGYSEYLRGIEEDFVVRQHWDVAWERHRECILDLGKAREWLRSGHGGTQGAFQKPGMKMPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L9</accession>
    <name>D4D1L9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024895.1">
        <property type="nucleotide sequence ID" value="XM_003024849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L9"/>
    <dbReference type="GeneID" id="9580386"/>
    <dbReference type="KEGG" id="tve:TRV_00970"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="110"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="326"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="643" mass="70955" checksum="893EF7E654AEBD89" modified="2010-05-18" version="1">MSVRFGQLLSRNLQRCAIRLPVTSTLAKHSIRRLPIAPLLTSRAFHSSPQFRVPAGTANAGVAVEDAGEAELITEFAELGEKGVVDQRLINAITKGMGLKTMTDVQAQTINESIQGIDMIAQAKTGTGKTVAFLLPVIHRILQDPTLGNLRRNFASAQDIRAVVISPTRELAEQIAVEAQKITRGSGLKVQTAVGGTRKREGLMRLQREGCHILVGTPGRLMDLFSDPTSGVAAPKLQAFVLDEADRLLDIGFAPDIERIQSFFPSRSQVDRQTLMFSATIPKSVKGLARSMLKPDFTFVNTVGDETPTHLRVPQRAVFLRGFENQLPALFEIAKRAVQAHAANPDTAMPFKAVVYYGSTAEVSVARRAFTALCRDLESLYTGRAPRIQTIEMHSRLTQAQRTFNSDSFRRATTGILFSSDVTARGMDFPNVSHVIQMGVPNDTDTYIHRLGRTARADKTGEGWILFPDIEFDAFGEKLRSLPIKEDTSIESASVDLTNPAQFSESIASVYDTLSKQFSRIFDDDKLKAYRAMNNQMSKYDKRESRRLLHQLATSIWGYPEPPYLPEPSPSRAGGRYNRSQRGGSGGYGGYSDRRGGSSYGGRGGFRGGSYGSGRDYGRDRGFDRGFDRRGSQGDRRRTSLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R1</accession>
    <name>D4D1R1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024839.1">
        <property type="nucleotide sequence ID" value="XM_003024793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R1"/>
    <dbReference type="GeneID" id="9580317"/>
    <dbReference type="KEGG" id="tve:TRV_01004"/>
    <dbReference type="HOGENOM" id="CLU_053720_0_0_1"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="37723" checksum="4FD98FC118C8593D" modified="2010-05-18" version="1">MAKDEHVAVTGDSKPVVPRTRRLTPELQKLVDREEEILDQLYEGNSVDTVDTGYRYSAYAARIRTLLLSAHRYVAYTSDIGESFRPVAHPWLVKGAYGVSWAYIFGDVANEGYKAYLRNQEILAPKSDAFRKATEAIAAGDVDVKSSADRKALEEHFMNKAALKDAEETLTSTACPKHPMPWKDPEEDTLVPWPTKKIPLSEDYRSVMAERAVFQSIASMGLPAFTIHSIVKYSGRAMKNMKGVFFRTWAPIGLGLSVVPALPYLFDKPVEEAVQWAFHNAFLMFGGPNAVPQETLPQGAFSEAFHAAQAVKKQRQEERERRREERRLRREKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1U1</accession>
    <name>D4D1U1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024761.1">
        <property type="nucleotide sequence ID" value="XM_003024715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1U1"/>
    <dbReference type="GeneID" id="9580283"/>
    <dbReference type="KEGG" id="tve:TRV_01043"/>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="500" mass="55676" checksum="A1F46725A9082BFC" modified="2010-05-18" version="1" fragment="single">LEARYVRFNIDALAAIAARCLGHDPASCVKIEKMPEGNFNKSLLLTMANGSQVIARVPNPNSGIPHFTTASEVATMDFARTELGLPVPRVLAWNSDASSENPVGAEYIVMEKAAGSSLAQIWPRLSNEEKREIVQAMVSFDVKMLNHPLSAIGSLYYPRDIPSGTNQLPALGLNDACGRWVLGPTTDRRFFDDGRGELSLDRGPSAICEREMKAIQNLNRPLRSEGIVGPGGYQPSRALKLSVCRDFLKVVNHILPPGACETPVLWHKDLHLDNIFVNPEKPTEIVGLIDWQNVHVSPLFDQVTHPAFLDYKGPKLEGLKTPCLPENFEELDEISKKHAKELLVAQTLYKYYDLYSASMNVPVYHALRYQETLQGEIIPLIGMILNDGEPALQGLLMNLARKWDQLIRSKGGPPCPLQYSAEAIDRQQELEAKWAEGIALMDDVLESLGGAIRGWDGWVSHEDYEALQQKLELVRKQFIEHLAGDDKEAAKAWARAWPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2F0</accession>
    <name>D4D2F0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024543.1">
        <property type="nucleotide sequence ID" value="XM_003024497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2F0"/>
    <dbReference type="GeneID" id="9579766"/>
    <dbReference type="KEGG" id="tve:TRV_01255"/>
    <dbReference type="HOGENOM" id="CLU_051524_0_0_1"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="314" mass="36026" checksum="69AA620A894683CE" modified="2010-05-18" version="1">MSKVCHGTLWKRVLPGYSINARSSKRTSLYLWKILATAYPAEFNQISHRYLLKPTSKKMAVANYLKLLTSVSVDWTAVVSLSVELFEPHEFLAVAKVRNLIGLEIRTQPKRTAFGYEATVSISDRVIKGWSEQALTGQAFEHLRILVLRLQTSLTEHMFAYLNAFSTLKAFIIQGCPRLCSKEARELAEQHGWEPVVVRYSDHSLYRTIVDMGSQLDSQTQDSRLTCIDSLPVVDFSLHCRNPKSLYPEEQILFRRKYQAPDHLSLQDQKAQKTHNDSDMAPSKPDLKQNKRVVRESCTKDMKDLLDQFKYDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2K7</accession>
    <name>D4D2K7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024482.1">
        <property type="nucleotide sequence ID" value="XM_003024436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2K7"/>
    <dbReference type="GeneID" id="9579710"/>
    <dbReference type="KEGG" id="tve:TRV_01312"/>
    <dbReference type="HOGENOM" id="CLU_058320_0_0_1"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="236" mass="27414" checksum="6F031AD40950CFCC" modified="2010-05-18" version="1">MADEDYSRASDEADREMTRLWRTWRTVFELLLDRGYEVTEEEVKISLSDFKQRYSDALGFPDRNKMRISARPSQAMMERYTPLPTPSKPNTVPECGTIHVEFCSETQSVGTKHIRAFNQFIDQQNYHAGIFITQSPISPSAIRLLTAIPGRFCEHFLEQELLVNITHHELVPKHILLSAEEKKKLLQRYRLKESQLPRIQSGDPVAKYLGLRRGQVVKIIRKSETAGRYASYRWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X0</accession>
    <name>D4D2X0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024463.1">
        <property type="nucleotide sequence ID" value="XM_003024417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2X0"/>
    <dbReference type="GeneID" id="9579685"/>
    <dbReference type="KEGG" id="tve:TRV_01426"/>
    <dbReference type="HOGENOM" id="CLU_014148_0_1_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930:SF2">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G04250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930">
        <property type="entry name" value="YALI0C12947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="869" mass="99722" checksum="B7D3CFE2EC0BD40A" modified="2010-05-18" version="1">MRRLTLQGTRWHPHALSTCLPRRAPSSLTLPRPFSTTRVSCLRDGKPKVSVRNFEKSITNSKEYFEVDPDTPDVVEHRRAREKLKKLETELDALKEGPFALDGEFMRSLSEEDRKRALQAITKYAAEHNWEEEDRRDEQLKNRMTAEFDQAINKELERLEAEEEELWDPTKELSGSAKTTEPVEQEREPFEVELKVPESHHAYVTRFNKALKSLKGTPSVAEKQFAWKSYRRCKEALPFFLDIAPEESIDMLWKSQRPSLNTSEKIPPRHLITLAEDLLSSGRILEAEQWVDYMDALLIDGQQEKALALWREREPDLNEYMLCEKKEYWNMGVRLFVANMNPKNAQDAALIYMSLDPSHSPRILIPVINCWAQSEDPENDVRAWTLYLHFKTSLGTDITMSDYDAISVGFLNSGKVNMALAVFKDMMLTGQNSSTESDALYKASLGLVGKLHSDSINESDVNKVSLASLTILPRKFQNKFFYASWIKKLIGMKELGAAAKVVELMYERGVKPDAKHLNGLIGAWLREGSGSSRQKAEELGWAMIRKRVDRICGDKSETLSVDGSLPGAAIPEYEQRTLPEATIETFSILLLHYTRRDKGALINHLVECLDKAQIRPNTFFANHLLYRELRKQNILGVWSGYKSTMANIRPDLETFACLWDCGKIQYDRTRSCFNAQFPNARALYSEMNQWYSNLPSQLQQHTQDAFSKDLYDHIIRCFCLSLDPEGTIVALRAMKQTFGFFPDADTVRILVFLVVRLIPTGDEATLPKRRHRRISSTPRAKENLQYVGGLLNKLREQKTVQAAKEGIYLDDMDQEFHMEFEVDLMCDLLRLVLRSMPRDPAEIEERIQAAARHMGVNDLYLGEPPSYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D323</accession>
    <name>D4D323_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024343.1">
        <property type="nucleotide sequence ID" value="XM_003024297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D323"/>
    <dbReference type="GeneID" id="9579482"/>
    <dbReference type="KEGG" id="tve:TRV_01480"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="57"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="513"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="772" mass="84794" checksum="8142C5670D96403B" modified="2010-05-18" version="1">MTSGKQEPVIVASCKQTRFHLAEGKGSGEIDIQGLDILIASRLSQSQDAESSGAGKGKARKKEKAGLGMEILTGANLRLKAGVHYGLVGRNGTGKSTLLRAMADRLIPGLPERVKIAILQQTDVEVGADSDPLSLAGKGTAALQANDESSKKVPKTLLQQVVQSDTARNEITRKVKTEVSVKVLSQALEDHEDPLAPVKAIRQLRHEACQHQLFLAQKNASLRSGARGLQARKDLKTAENRLEESVERLNDDLTTLDASKIEQETQAAVELLADVEAQLESMNVVDLDQEARKVLLGLGFKDTDFDRPFLSLSGGWRMRCMLAGALIQSADIMILDEPTNFLDMLGVIWLETYLSRMQENSDKTVVVVSHDRAFLNNICEELIILRDKTLTYFKGNVSAYEQDRESQKLYWGRMKEAQERQTTHIENTIKNNMKIGKKTGDDNKLRMAKSRQKKLDDRMGVQVSATGGRFKLSRDRVGWHDSMRAEIEVPADEKGVSIDLPEAPDLRFPGPLLSLEGVTFQYKHSGPVVLKSIDLVMHMGDRVGILGLNGCGKSTLLKILVGTNEPTQGKLSRHPRLKLGYYSQHSVEELQELGRSSPTETGLSLLCRETEGVLDEGEVRGMLSSLGLPGRTASDVPVCQLSGGQLVRLALARILWPMPHILVLDEITTHLDFHTVLALAAALSSYNGALLLVSHDRYLVRKVIEGKENLEGDDDGSGGMAEHEAKGRGATAVDESQRRDVVVLKAGKLQLQEDGVDQFEANLQKRVRKMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H3</accession>
    <name>D4D3H3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TRV_01633</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024200.1">
        <property type="nucleotide sequence ID" value="XM_003024154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H3"/>
    <dbReference type="GeneID" id="9579238"/>
    <dbReference type="KEGG" id="tve:TRV_01633"/>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="313"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EFE43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="693" mass="78965" checksum="BC9E17234740CAF3" modified="2010-05-18" version="1">MPMQKFQHPGQHPQHPQQQTQQQQQQQQQQQQQQHHAPHSQSNPVLSHQQHSYSAGALSNAAAQHFTPSHLQNGSSANLEDEIDEPMNEHWQQQLQLAAESRQANSPHYYARSVAQQTKGIQLSSHQNDSNENGTEDRNRAVAVKETRRQDWMAIDFGGQGLRALSDGLFHYAFLDKLYLNHNKLKTLPRKIGQLKNLTHLDVSSNELTEIPEEIGMLTNLKRLLLFDNNLQTLPFEMGYLCELETLGVEGNPLNDVLKSRIMQEGTKALIKYLKEETPAWVVPMPPSDRDWIVLDESGRGSSKNPHDKFTVLTYNTLCDRYATHQQYGYAPSKALAWELRRDLLLSEIRGQDADIVCLQEVDQGSYHGFFREQLAYNDYKGVYWPKGRAQGMSEEEAKVVDGCATFFKGSKYILLEKAMIHFGQTAVRRPDAKGQDDIYNRLWQKDNIAVVVYLENRMSGERIIVVNAHIYWDPAYKDVKLVQSAIMMEEVTQLAEKFIKIPPCTDKTAFRFSEPEDETNNSENTSPPTPVEPSPSVEYSSPSQIPILVCGDFNSRPSSAVYNLLAHGRLEEEHPDLRDRLYGNLTRQGMTHPFTLKSAYSAIGELSFTNYTPGFTDVIDYIWYSSNLLQVTGLLGEVDKEYLQRVPGFPNYHFPSDHLALMAEFSVKNKKGKVVEVDFGPQRDRDKDRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J9</accession>
    <name>D4D3J9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024160.1">
        <property type="nucleotide sequence ID" value="XM_003024114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J9"/>
    <dbReference type="GeneID" id="9579198"/>
    <dbReference type="KEGG" id="tve:TRV_01659"/>
    <dbReference type="HOGENOM" id="CLU_271604_0_0_1"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="7">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117705" checksum="C138AAD279A7CD7A" modified="2010-05-18" version="1">MELLKNWIEPLVATAISQSADKNDPNLRPRELKTTVDDGKNFRIPVTRPKYAQLLEWLPEAPTPQAILSDSHTFISARFSERVCQNFNWNNNSYSRSNVTPCLLRIKQCEIVIAKSNKFPPEISLYIDEIKLEGCEKEGVFGNPGHIVQCKAVIELKDKWFRKIHILGPTVPSPRNDESGRPKSQADAPTPNNGGNSKPTGHHDNSTRENGWHTQPPVIISQTSRAQENKDSVAVQLSNAQEPQQALPPKSTIPKNRPRSSPTVEHSTKNDDKQAGQTTPLPVATDSSSITSSPRRQSYSNSVGKATQKAHPIPSQTDQHEVISSLEERTTSATCPRHSSRSRHSNNLFRPDDSEVIKQVSNRGFFSSWNKIRRRDVIIPESQLNLIECEDSWIPPDPGKKTPQNFVPLELLQEWSESHKKETSSIGTSLRRSPTLGEGASSTGSPAPDDEIGSEDWPPTSPVPLVPLDSSPPRRSVNSSATPSNKRTSVANPTDSTDAPNHPPPTNVPGFATKAEEVFDDKSCPDSEIELSIPRDLYTSTQNCDTGMDNNEDVTRLSGTMLSQQLKVQPAPSCESTKHDLVTQNSSTNNDPLVVTSQTSGEWSAGSGNVNGSTSILQVPRSSLENADHNALILPSTKASASVPLLDNTNQQHKRKAGSPSLPPYPRKVPRIAEVDRSSSAAVPSHWGGRTFDKVKFSSQTEEIYYKFQQAYKTYTGSLEVFRRACCRLQFLRNGLLKRSILWDDFVAREVLEYQNYLQRCDQRHKKPNTYEDYFEKHAKFPLYKRRNLTVKNLQAVVTEAEGESDCASELGDGPRKEATPELQCTSTLKRTIPESPCKHGIQDWESEGSDSETTKVNLEASSHDRASVELGDEPYCRVSVNKSWKRKATPFKEDEAKESEDEDVFHSVRGSLHRPIRLSHEMDTDGVSTNNTYQKSSGSSSLLAKGPTASLPKPKEPNMPSKAKPSRPKRSPAPSLPSHRNTSSTKKTRSAAIPERSTSWKDPNTSLKVFLRDYVRIPGELGTLDAGLNSGDVPIDEAGVVLIKPRKPPQVGGRMNSMGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Q5</accession>
    <name>D4D3Q5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024117.1">
        <property type="nucleotide sequence ID" value="XM_003024071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Q5"/>
    <dbReference type="GeneID" id="9577113"/>
    <dbReference type="KEGG" id="tve:TRV_01716"/>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="276"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="484"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="844"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="104559" checksum="93BEA9CF8F9EE665" modified="2010-05-18" version="1">MAQSATALPFYSSSAAASPRLSSPLPLLPTPTRPRSTPISLPPPDVDHRIDAGEEEALSHHHSLARVSSQVLAAMDALNVFAKRDEPEKPSEASNSLSGFLSTLVPTAIISAIMVVLFLILRQSQRRQYVPRTYIGALRQHERTPAPKPGLFGWVSSMWSLPDTYVLRHQSMDAYLLLRYLKIATALCFFGCLITWPVLFPVNITGHGGRQQLDMLAIGNVDAKRPGNLYRYFAHCFVAWAFVGFVFWMVTRELLYFINLRQAYFMSPLYAERISSKTVLFTSVPEEYCDEAKMRAMYGNDKVKNVWLVTDVKELEKLVEERDKAAFLLEGAETKLIKMANVARGKALQKGGEVDDPAAHGNIGEAESGSVAARWVKPNQRPTHRLLPIIGKKVDSINWAREEIGRLTPDIDNLQRNHLNGQAKRISAVFVEFINQNEAQAAYQMLAHNLPLHMAPRYIGINPSDIIWSNLRIKWWELIIRYSVTIAAVTALIVFWAIPVAAVGAISNIDYLMAKVPFLRFIGKIPPVILGVVTGLLPTILLAVLMALLPIVLRLLAKLGGCPTKAAVELRTQNFYFGFQVVQVFLVVTLSSAASSAVSDIIKNPSSAPGLLARSIPTASNFYISYIILQGLTFSAGALLQIAGLIISKLLGMILDNTPRKMYIRWATLSGMGWGTILPVLTNLVVIAITYGAIAPLVLGFATVGMLLFYLSFRYNVLYVNDTDIDTKGMIYPRALKQTLVGCYLLIICLIGLFAIGTASDRSATAPMILMIVFLVFTILYHISLINAVNPLLNYLPKNLEAVEQQHQALLAQNNNGQPAAHNGDVEKGDVRGATNQPNMIAKFLGLNKYEGYEQLRELVPHGAYDTDYPAEVERNAYYHPSITSTAPLLWIPRDAAGVSRQEVIHTSRYIGITDEDATINDQGKIAWDEERGAPPIQEEKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D474</accession>
    <name>D4D474_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023947.1">
        <property type="nucleotide sequence ID" value="XM_003023901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D474"/>
    <dbReference type="GeneID" id="9582640"/>
    <dbReference type="KEGG" id="tve:TRV_01888"/>
    <dbReference type="HOGENOM" id="CLU_1587686_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="168" mass="18343" checksum="69D652D25E366B18" modified="2010-05-18" version="1">MTNFNHERLTIAVGVTRQARVALSAAFEYCMKREAFGKTLMDQPVVRHRLSKAGAELESMWAWVEQFLYQMSHMPKAEGDRRLGGLTALAKAKAGMVLNECAQVAVLLFGGLGFTKSGQGELVEKILRDVPGARIPGGSEDVLLDLAVRQLVKNFKAEGKKLGKAANL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Z2</accession>
    <name>MEP1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable extracellular metalloproteinase 1</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fungalysin MEP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEP1</name>
        <name type="ORF">TRV_02160</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase probably acting as a virulence factor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EFE43079" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="ACYE01000116">
        <property type="protein sequence ID" value="EFE43079.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023697.1">
        <property type="nucleotide sequence ID" value="XM_003023651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Z2"/>
    <dbReference type="SMR" id="D4D4Z2"/>
    <dbReference type="MEROPS" id="M36.001"/>
    <dbReference type="GlyCosmos" id="D4D4Z2">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9582244"/>
    <dbReference type="KEGG" id="tve:TRV_02160"/>
    <dbReference type="HOGENOM" id="CLU_012703_3_0_1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397724" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397725" description="Probable extracellular metalloproteinase 1">
        <location>
            <begin position="247"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="635" mass="70069" checksum="8339BFA134DBBE74" modified="2010-10-05" version="2" precursor="true">MHGLLLAAGLLSLPLHVLAHPQPSTSTSLAGRAGAVDLNEFRIAHRSSYTSHDEMKKLPSIASFRQGTYLEVATELVKQTIPNMEFRLVDDHYVGDSGIGHVRFRQTMHGIDIDNSDFNVNVGKDGKVLSHGNSFYTGPAPSSNPMVKRDFIDPMQALHGVRKALNLPIKADGAHVEDMSEHKVMFKGTSGALSDPTAKLCYMAKEDGSLALTWRVETDIGDNWLLSYMDAKESSKVHNVVDYVAHATFQVYKWGLADPTEGKREILTNPWNLKTSPLTWLSDGQNNFTATRGNNAIAQYNPDGGNDYENNYRPSPKNLKFEYPYSPDMNPPKTYIDASVTELFYTSNVCHDLYYMLGFNEKAGNFQVNNRGQGGKGNDFVILNAQDGSGTNNANFATPPDGQPGRMRAYIWTRANPPRDASFEAGTIIHEYTHGLSNRLCGGPANSRCLNAIESGGMGEGWGDFYATAVRLKPNDTRKTNYVKGGWVNNSPKGVRMYPYSTDMNVNPLVYTSNNKLNEVHAIGTVWCTMLYEVLWNLIDKHGKNDGPVPIFENGVPNDGKYLAMKIVMDGMAIQPCNPNFVQARDAILDADMNLTKGANKCEIWKGFAKRGLGVGAKFDPKNRTGSTQVPNECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5A6</accession>
    <name>D4D5A6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023529.1">
        <property type="nucleotide sequence ID" value="XM_003023483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5A6"/>
    <dbReference type="GeneID" id="9577001"/>
    <dbReference type="KEGG" id="tve:TRV_02276"/>
    <dbReference type="HOGENOM" id="CLU_030844_1_1_1"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="467" mass="51932" checksum="557A93E74C2C8CCE" modified="2010-05-18" version="1">MWYNVSEPNEYLVITGAGIQDVLIKKTAFLLPWQKCTRISISPFDFSLNLQAMTIEKLQFSLPAVFTIGPDNNLASLKKYALLLSGKSGRQSNSSHASGNYVQDIVKGIIEGETRVIVSGMTMEEIFKERQLFKQHVIDNVQKELDQFGLRIYNANVKELQDAPGSEYFTYLSRKAHEGALNQSKIEVAEARMRGEIGEAEKRGKTKQEISRIDAETAVLETKRRSDKLQADAQLTNRQTELNMGIELARIQAKRHAEAKDSELQKHVETKRAETELERLRALDVTKSKAAREAAEQTAEATYFSRTKEADASLYRSKMEADATYYRQTKEAEAAFYAKQKEAEAMAEMAKGYGAMAEVLGGPQGLLQYMMIQSGTYEKLAKANGQAIQGLQPKISVWNTGNADGNSSAADATAPLRNLMQSMPPLFSTIHEQTGIAPPNWMVQMPPPEKQHPVNPQKFAGAKANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5B7</accession>
    <name>D4D5B7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023540.1">
        <property type="nucleotide sequence ID" value="XM_003023494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5B7"/>
    <dbReference type="GeneID" id="9577012"/>
    <dbReference type="KEGG" id="tve:TRV_02287"/>
    <dbReference type="HOGENOM" id="CLU_141804_1_0_1"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="157" mass="17624" checksum="47C9BF261E93C543" modified="2010-05-18" version="1">MESIPISINTLSIDEPILESPTTPRSCAMALAARRSNLRDTHIQHHQTSSPQLSSQSPSSPCPPPARIPRHPSPIRYQSTPPSSRCFADILDPTLNLSDDNGDRSNDVDLQVKLALIDLLNCSDIKTDQESRLWVQNKLMDTEHRLKARRRSRVVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M1</accession>
    <name>D4D5M1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000123">
        <property type="protein sequence ID" value="EFE42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023470.1">
        <property type="nucleotide sequence ID" value="XM_003023424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M1"/>
    <dbReference type="GeneID" id="9583489"/>
    <dbReference type="KEGG" id="tve:TRV_02394"/>
    <dbReference type="HOGENOM" id="CLU_1116434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="27889" checksum="92780A5F7D6390FF" modified="2010-05-18" version="1">MVVTGDGGSWAGETPAAEGGTQGQQRMDDACLSSRWLAGWLAGWRSLVAGVLSQAVDLRRRGSQLRESKQRTTTREETAESQESRVKSQEEEEEEKKTVRERERERESERVTRVKRERERREKARKRRAVREEEDVREDVREDVREEKKRREGRDREDDEILLLSPHSSVLAELAVSALGQDRPLAHPLVSSGLSSGLSSAAHLPLLSCFSLLLLSSLLSMDAAAAPETWRFSCTVPSCLAASLPRCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M5</accession>
    <name>D4D5M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023461.1">
        <property type="nucleotide sequence ID" value="XM_003023415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M5"/>
    <dbReference type="GeneID" id="9583485"/>
    <dbReference type="KEGG" id="tve:TRV_02398"/>
    <dbReference type="HOGENOM" id="CLU_021598_2_0_1"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="500" mass="57517" checksum="359CCFF29B444202" modified="2010-05-18" version="1">MALALTTLPLEIQMLIFSYLPNSTIKNLRLTCSSIKNAARLDLDRVFLSIQKRDIEVFRSIASHDTMRLQVKEIIWDDGSFSQSPLEEVVEQDGEYYGQVSGLPYEKVPAEQGSSPKFCPIWFSQECDQNISGFAADKYGPRMAEEMMGWMMMLQRPLPWKSWETYKEYLRDQLEVLDSEADVEALKFGLEQFPALRRITIIPTAHRKLFEPLYPTPNIRSFSCIFNYPIPQPWPVSNEDTFPVNATPWTEDAKEFLKERWRGFRVVTRCLAEQAGKHHVSELVIDPGNLKTGINYNIFNTPCQELSNFTTMLEQPGFKRLDLTLFVGGNEDIVWTPFKDSHYHSAFSKCPDLEHITFGTDRGIYATEELSMEHFTSLLSLFPVQKWSKLRHFGLSSFPVVQSDIIDLLDAMPLTLRTVELTGLLFINDGENYNSLLTAMRDTLNWKERAVGDRPQVTFWTKSSVNMLHAHMQKTVSNYLYGDGENPMKVGPDRKMYFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5U3</accession>
    <name>D4D5U3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023364.1">
        <property type="nucleotide sequence ID" value="XM_003023318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5U3"/>
    <dbReference type="GeneID" id="9583384"/>
    <dbReference type="KEGG" id="tve:TRV_02466"/>
    <dbReference type="HOGENOM" id="CLU_024136_0_1_1"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="599" mass="68859" checksum="1DF0971E7250F6EA" modified="2010-05-18" version="1">MEAFASAVPEPLSPTKRRRSGLVKTCEGLLCSAVKYFPLVFVYGLTTWAVWVEAGVSIYHTRSWWKGTPSPIHMKHFFDRRSNKATGTLGSVFGISLYLLMNTSYTVAVFTDPGTPLKTSTHGRSRHQYSHLPTIEDPEYSSVTVNSMGELRYCKKCRCRKPDRAHHCSTCGRCVLKMDHHCPWLATCVGMYNYKAFLLFLIYTCLFCYVCFAVSVLWVWDELMKDAQYMERFLPVNVIILAVISGMMSLVLSGFTGWHISLSIRGLTTIECLEKTRYLAPVRKTLDRQRREWQHHQPDAQNMGATTKDFGRTLQGYGQQFIDMHANAIPGVTRAEEGEERSSPTIGTRIPDRRHQHNDYNPDEHYEQYQTPAQQSLFRSYGELDRAREHDRYEEYLAECDSEKLPHAFDLGWRRNLQHLFGPNPFLWPIPICTTIGDGWRWEPSSKWQEAKARVEQQRHQRWEEERLQRQQFWQRAAKTSRSLPTTALHHSWHASEPHPGNSWTGRFNSTGNMRASPYMGSSAEDRPSTGVSMKTLRPMSPRPRPGEREEDIDEASDRYSTSSDEASEQHALVANNTAKQALSNSAAKGVTEEWVNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6A7</accession>
    <name>D4D6A7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000136">
        <property type="protein sequence ID" value="EFE42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023228.1">
        <property type="nucleotide sequence ID" value="XM_003023182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6A7"/>
    <dbReference type="GeneID" id="9583254"/>
    <dbReference type="KEGG" id="tve:TRV_02632"/>
    <dbReference type="HOGENOM" id="CLU_2741878_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="71" mass="8052" checksum="E9BCF672CCA117A8" modified="2010-05-18" version="1">MVTETLRNARREEEEEEDDDEVKEEEVKEEEDEGRRGRGIHGVTRASDHVACVVSFGKAPRLGSAKRNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E1</accession>
    <name>D4D6E1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023203.1">
        <property type="nucleotide sequence ID" value="XM_003023157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E1"/>
    <dbReference type="GeneID" id="9583223"/>
    <dbReference type="KEGG" id="tve:TRV_02666"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="390" mass="42628" checksum="0BB0139AEC30C940" modified="2010-05-18" version="1">MSSNMSLVICAPATLAIAHDLNTNNNFLLVFYLTAPNLGEAIAPLYIGPLSEKFGRLVTGFSSNINMIVAFRFLAGASTLSICLNPSIIGDLYPVKNRGAAMSVMSLIPILGSAVGPIAGGYITQGLNWRWTFWLSAMMTGILLLVSLCVMRETYLPVLRREEHNEKISSGSKYFKGWKWSTIKGLCLLAVRPFTILFSSNVAIIMACYLSIHYAYLSLLAATLATTFQDAYGFSESHSGLIYISLTTIGTDDQPLPENRLIPTIPGMALFLVGLFIYGWTSQHHVHWIVPTLATSLCGFSLASSTTPIMNYLVDIFGDRSASAVAAVLPMRYLMGTFLPVAAPYMYKSLGYGWANSLLAFILLAIVPFPLRAIVQPKAVSSMHRMEAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E2</accession>
    <name>D4D6E2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023204.1">
        <property type="nucleotide sequence ID" value="XM_003023158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E2"/>
    <dbReference type="GeneID" id="9583224"/>
    <dbReference type="KEGG" id="tve:TRV_02667"/>
    <dbReference type="HOGENOM" id="CLU_053570_0_0_1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF423">
        <property type="entry name" value="SYNTAXIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="269" mass="30146" checksum="F71C888E00FFB1AE" modified="2010-05-18" version="1">MSNPSQLFLLADHIKLSLLERQRAISLDLEPNAQDGEISRSLESLREGLESAEREAQRLVSVGDASSNDFKEQTSSLRTQYEDLSRQFHGDNAPSLSTQPNNEELAEDFIRASSTPSILKHPTPQHPVSKSVRFTDTLTASAEEHDPNRDALLRPYSDSPQPSFDPSEATNQEIHDYHNQVMQEQDEHLDRLGESIGRQHQLSIQIGDELEGQVALLDDMDGHVERHQGRLDGARRSLGRFREKSKGSKGMMTIIGLIIVLVILIVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6F2</accession>
    <name>D4D6F2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023214.1">
        <property type="nucleotide sequence ID" value="XM_003023168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6F2"/>
    <dbReference type="GeneID" id="9583234"/>
    <dbReference type="KEGG" id="tve:TRV_02677"/>
    <dbReference type="HOGENOM" id="CLU_009961_3_1_1"/>
    <dbReference type="OrthoDB" id="4171227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="632" mass="72915" checksum="FA337456BD3B5230" modified="2010-05-18" version="1">MSRTILRPLQRLTLSVLRRDQSSNGFTKDKAKLQDPYFIDEYDLTSPGENSVAEDGDDDGMAFLESLLVLGEDDKRTSSQGLTAAGLANILTLFPDICPRYVTTLYQPMLARKPENFEGALIDAILKEATYTTVSGSRQKREDMAKDVHWGKEDNLTRNSRYWKCCKALLKLDFPLVPTDYIKEYLEVTNDCLYNAYLRLYEVESTYETSDPKPYSRNTDVKREKLMASFRKVVAKYPNRDIDLEIKDARAERKRRIVYCAAAAAHPFCWECIKSNAKAQVGMMRHSIKCMDINGCDAGFSREDLINSAGDSLMNKLFDLQQLEEIQQADLTDLEECPFCEYKAIYPPVEENCEFRCLKPGCMRMSCRRCQRPSHIPITCAESRREDSKNLRKHVEEAMSKAVIRICPNKKCKAPIIKEDGCNTLKCRKCSTVMCYVCKKNISRAKDSHFDMVGSCPVEDDRYLLERHERERMTARNEAVESLLKDKPELNEEDLGVELIKRRTVRDGLPIVYPEGTPDTSEMPLWVFGERVSGRPDRQLQRWPQLRVRFPPANQDTQLPINYEYQAIETIGVLPAPSQNPQDSHYQQTQWFSFNAYAPYPLPPDLPVVRYEREQNPHWFKGLRRAQPSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6J4</accession>
    <name>D4D6J4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023141.1">
        <property type="nucleotide sequence ID" value="XM_003023095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6J4"/>
    <dbReference type="GeneID" id="9583176"/>
    <dbReference type="KEGG" id="tve:TRV_02720"/>
    <dbReference type="HOGENOM" id="CLU_074379_0_0_1"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="239" mass="25683" checksum="41E0285393CD135E" modified="2010-05-18" version="1">MTSITEQRNDQMANSPEQTDQLMDYLLATHKLEDLQASLLNSLSTCGWTERVRSLAFELFRTEDHSRFEDVVDTIVSMATSGSGASSGSPSLGKRKRDGEEDSKLANGAVKNGKRVKPNPTTSTANGAGEVTVKKETAEGSNSIAESGPLASFGSSASDIAAHYNVQIPERAVNSGVKFLQDSMHELFSSDTEDQPNGTRGHDPESDDDIPIARKEMKKKASDQPKTNGHPLPKSNTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D744</accession>
    <name>D4D744_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022936.1">
        <property type="nucleotide sequence ID" value="XM_003022890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576962"/>
    <dbReference type="KEGG" id="tve:TRV_02923"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="955"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="35"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="360"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="705"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1306" mass="143957" checksum="805B8896D3852BC8" modified="2010-05-18" version="1">MPANEIDQGAKPSGFKSYRRIFRYADRKAWLLYSISFLAAIIGGSALPLMDLIFGKFVTTFNNFANGSISSESYIQEVSKYSLYLVYLFLAKFFLVYIHTLAASVAAIRTTKALRLEFMQSLLRQDTSYFDSNKDGSPSVKVTMNGNIITNGISEKLSVFIQSCATFVAAFAVAFGVQWKLTLITICIVPAILIITGVCMSIEVKSEDKLMAILSRSSLVAEETFSSISTVHAFWLQPLMAQRYEEFLAELESVGRKKSPNYGALFSTEFFCVYSGYGLAFWQGIKMFARGDIQESGDVVTVIFAVVVAATSLTHIAPQIITITKAAAAAEELFRIIDKESAIDSLSTSGLAPEECVGEIKLEGLEFAYPSRPDTKVLDGVDLNVPAGKTTALVGASGSGKSTIIGLLERWYDHTAGSILLDGIKIQELNIAWLRTQIRLVQQEPVLFSGTIFDNVAFGLVGTQHEDAPYEQKLALVKEACKEAYADVFIDHLPKKYDTQVGERARMLSGGQKQRIAIARSIISHPSVLLLDEATSALDPKAERIVQSALDNISIGRTTIIIAHKLSTVQKADNIAVMSAGKIIEQGTHHGLMANDGAYARLVRTQVLEQKSRGMTENDLATDIDEQDDWDEGKYNLDEKETRKERDDEKQITYLTTHHARSIASDTLEPNFNAQAKETMGYHLIQCLWLLIKEQRNLWGSYSIFAFACILGVAGATFPTQAVILARTLEVFQLRGSEAVRRGNFWALMFFAVALANFVIYFFVGWVANIIIQVSFPFLYSKVGALGLTTETTLTLQEVSRRYRRELFRNTLKQDISFFNLEHNATGSICARLLIHASNLNELLGINSGLILINVVTIISVSILGIAYGWKLGLVCVFAALPLLLLSGYFRIHLESKLEEDTSTRFASSAAIATEAVLAIRTVSSLTLEKRILQIYQERLDVVAHQSVKALTFTMFWYALTQSITFLAMALGFWYGGKLVSTHEYTNEQFFVVFTAVVVGGENAAALFQYTTGITKATSSTNYIFWLRQRVPAIDNDFSNEPPANDSFENNETVAIDCQTVNFAYPSRGGSKNVISDINIRIPPGKFVAFVGPSGCGKSTMINLLCRFYDPTTGFITFNNQAIHEIDLHGHRRRLALVQQEPILFQGSIRENIAMGLIDSSEVTDAQIEQACKDANIYEFVLSLPDGLGSEVGIRGSKLSGGQRQRIAIARALVRDPKVLLLDEATSALDTESEKMVQDAINEAAKGGKRSIVAVAHRLSTIQSADTIYVFQAGRIAEAGAHIELLGKKGDYYEMCQGQALDTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D753</accession>
    <name>D4D753_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022945.1">
        <property type="nucleotide sequence ID" value="XM_003022899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D753"/>
    <dbReference type="GeneID" id="9576971"/>
    <dbReference type="KEGG" id="tve:TRV_02932"/>
    <dbReference type="HOGENOM" id="CLU_027223_2_0_1"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="453" mass="50977" checksum="33D5DBF42BDBBD75" modified="2010-05-18" version="1">MTRSISSCRTAHRPRIQLLSRNPSISQSRSYTYYQRFRDNFRVAARNVHRKHPIGFPLTLLFAVGNTALLVYIVYDFMTRVNPEFTKFPKEIATPLRKAVYYTEMDLNPPSALAYYKQALAAGYQLGLHPFSDEMLGIRLAVAAMLEKAKLFDAAIEVLTTIKHDCETWIDNGRRRKLIMDRENQSGKNTRPDPSDFDAVAEHEAGLKKEQEEEELRDKVVKKIPGISLKLADIYSEQYPDDTAKAEKFLTSAFETSRAELQRRRDLKLPITSDEENPAYLTLSEVGNACSELADHYVNKGRSDLATILYMQAISLFKEDEGDGRHKCIQAVLLNNIASQMAEQAGKVPLGAALPSSASLNPVSRDQLLSAAGEWAKKALDVASNVEESYKNEQCDQACVVALFNLGEIAEMQENSHQAEDFYRKAKAAAVKVQFAEGTEQAEDALKRLRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D756</accession>
    <name>D4D756_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022948.1">
        <property type="nucleotide sequence ID" value="XM_003022902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D756"/>
    <dbReference type="GeneID" id="9576974"/>
    <dbReference type="KEGG" id="tve:TRV_02935"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="295" mass="32998" checksum="2D0A45D303069EA1" modified="2010-05-18" version="1">MYIARRSFYFPWPATARAAPGTNIRNPKVGHRDSSAGDQAHPDQPPFSPQAPLVVILLPRPPRSPYYSLLSTAETNMRRGSAMGLRSPFELLFLLFTLLVPLTSAVRFDLIPNTHSGKHERCIRNFVARDQLVVVTATVSGSKGDGQVVNMHIKSSLGDDYAKPKDIAGEIRQMFTASADSSFDVCFSNVLSGRHAGPNPSRQVELSIDIGADARDWDAIKVQEKLKPVEADLRRLEAMITEIVAEMDFMRAREQKLRDTNESTNERVKWFAFGTMGMLIGLGVWQVVYLRAYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D6</accession>
    <name>D4D7D6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022856.1">
        <property type="nucleotide sequence ID" value="XM_003022810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D6"/>
    <dbReference type="GeneID" id="9581580"/>
    <dbReference type="KEGG" id="tve:TRV_03018"/>
    <dbReference type="HOGENOM" id="CLU_612796_0_0_1"/>
    <dbReference type="OrthoDB" id="4172586at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="437" mass="49737" checksum="BF73CCF66D787682" modified="2010-05-18" version="1">MSTAAFINIHVQQNGKEQQRGLGINIETSFHLVKEDHLIVHSLTGHIHTTTMTIQDLPPLSKRSGITDHHMDTHLMNLTVLHRWPDMIMIPMALCHPTTIMMLLPQVIIPAALLDVEKAIILNIPWKDPHLHGMHHHVAAIHGEGKVVKAEMDIRPHTPLTVHRIVCFIPLLYIHHTYLITLLQFAAWRSPHAVGRPLPSVFSDLDDICKLPPHTSLPPGMSVSKYFLNKGADEFNENIRNTEDWPFMMGDPIFSEFPSDGETIPVKDLINRQKDMMAAHKYVPPKPVVEETTYDSEQADEPEIPDDASYAGSEEQGQANGAESPEENGSYTGSEQGRDHDREYKRHHGQAWNTEDNTNTPMSTTPGNNDSDERPQTPQRYSKPQNFHGSYHRKRAREESLELPDDEIQRQVDDVAPRLERRHPRVAEAYRYDINIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7M9</accession>
    <name>D4D7M9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022731.1">
        <property type="nucleotide sequence ID" value="XM_003022685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7M9"/>
    <dbReference type="GeneID" id="9581427"/>
    <dbReference type="KEGG" id="tve:TRV_03113"/>
    <dbReference type="HOGENOM" id="CLU_041732_3_0_1"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="28635" checksum="E6C4D1F7D8CF72A8" modified="2010-05-18" version="1">MPVSTASDNGDEDDFIVDIDGIQAHEENKTDAEKGVGAADITKLKVNGFYTVASVHGATRKTLLKIKGFSEVKVEKIKEAIQKCQPSASGFITAMELGHQRKRVVKISTGSKQFDTILGGYQPYFSYEIKKKPKKERKPETDGSLPKDMGGAEGKAAYIDTEGTFRPERIAQIAERFGVDPDSTLENISYARALNSEHQLELLNTLAKEFASGEYRLLIIDSIMNCFRVDYCGRGELADRQQKLNQFLMKLAHMAEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D815</accession>
    <name>D4D815_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022593.1">
        <property type="nucleotide sequence ID" value="XM_003022547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D815"/>
    <dbReference type="GeneID" id="9581248"/>
    <dbReference type="KEGG" id="tve:TRV_03250"/>
    <dbReference type="HOGENOM" id="CLU_101495_0_0_1"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="239" mass="26225" checksum="CAADFEB39F548E49" modified="2010-05-18" version="1">MPRLGMREAFSPRDARDGEEFLTAGGNNKSSLGATKIVMAADSRDQASQAEAPTKAEPTTADGKTKYEISKSQVGKLWEELGNPKEPVNLMPGGTYNSAGGKPKEVTVMDSLRSLSLEKFASVYKAPCARDSLLLGIGTGFGVGGLRAILGGLKSLWSASNWAVGSFAIVSLAAHEYCQRQRAIEREGMKEAAELMRELKLKKQKEREAARKLHEEEEARKAEEARRKSWTNPSNYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8H9</accession>
    <name>D4D8H9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022465.1">
        <property type="nucleotide sequence ID" value="XM_003022419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8H9"/>
    <dbReference type="GeneID" id="9581012"/>
    <dbReference type="KEGG" id="tve:TRV_03415"/>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="133" mass="14974" checksum="4D8CCD002117F35D" modified="2010-05-18" version="1">MAKVNTAIACSRRKSRKAHFSAPSSERRTIMSAPLSKELREKHNVRSIPIRKDDEVTIVRGTNKGREGKITSVYRLKYVVHVERVSREKSNGQSVPIGIHPSKVVITKLKLDKDRESILERMGKGRAARAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8N7</accession>
    <name>D4D8N7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF821 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022410.1">
        <property type="nucleotide sequence ID" value="XM_003022364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8N7"/>
    <dbReference type="GeneID" id="9580957"/>
    <dbReference type="KEGG" id="tve:TRV_03474"/>
    <dbReference type="HOGENOM" id="CLU_028539_1_0_1"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="163"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="437" mass="49969" checksum="CBD65A5A74627ABE" modified="2010-05-18" version="1">MVFSLWFGMNSDRDNVHPLLTHIIPAGHCTCQTSTTFNCSESLATLPKKQPSSPAPVPSADWNFEFDRDKANVNLSPLQCKTAFPGLFEDPYRAAAFWDSQPGISTEHLDKIELKNGMARAIIHRGELYIVATQAAQEDHRKKILAVLSSMHHALSATAGNRTQPSIEFVFSIEDRVDDISGTGHPIWALSRKASEESIWLIPDFGFWAWDNAANAIGPYNQVVDRIQRQEVTVPWSSKENKLVWRGKLSFAPKLRRNLLDIARDTSWGDVKEIVWSEKQNFISMDSHCKYKFIAHVEGRAYSSSLKYRQACRSVVVAHKLQFIQHHHYLLQSTGPYQNFVEVERDFSDLPTKMEHLLSNQDLAERIANNNVKTFRERYLTKAAEACYWRELWASWANVFNAVITDSFADRGLRFESFLLLESQKMMAFSHSNVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8P2</accession>
    <name>D4D8P2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022415.1">
        <property type="nucleotide sequence ID" value="XM_003022369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8P2"/>
    <dbReference type="GeneID" id="9580962"/>
    <dbReference type="KEGG" id="tve:TRV_03479"/>
    <dbReference type="HOGENOM" id="CLU_028356_0_0_1"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="51"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="587" mass="64946" checksum="181F3E5FF49C16D7" modified="2010-05-18" version="1">MSSAASSASSVQSGRSGGTSHVHGHSYSPDQSRAQPDLDTLVSHLAAAKRSLSSIHHVWRANEIVTAARAALEESVIVSARTGFLRRGLDEQIRLLFKVRTEVEEVAHRGRAEFSAAIKELDTVDRRLQQTLDSLREITLEPAFRSQEQRQEEAERGVSKTLHDFIDEHAVDDIRSLLKDAIDNLSAAQTELDVSNRAFDNDLQSIQQALDKYRLSVKRGSVSSLSLSASSSASRVKMPTPAVIPEFLHSLELNAQEMADLLESLVRHFDLCVTAVKHTEGGGILARNITGDLPTDVGVGIRAGGNPQSNTSDCNNINNDDAGNPNPQLEPLTDSDYRDMINVIAKDAGEAEDVVLEIQDRIAEMESILERVLEQRDSLITAGVSTTAVYRRLVEFQSTRLLGYVAQSHKFEQTWKTEHERMESGVADLNDLRGLYMGFLDAYDGLILEVARRMSVKRAAEDILHDARARLDALYEEDVRAREAFRIDQGDYLPSDIWPGLSMPPSRVVFRRIREDDDTAQENKDETTSGAKPDDVDQQHPEGDVQPTTKLNSSSKGDFGESIPSLPKHVIEQAFARLNARGTRLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X9</accession>
    <name>D4D8X9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022356.1">
        <property type="nucleotide sequence ID" value="XM_003022310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X9"/>
    <dbReference type="GeneID" id="9580903"/>
    <dbReference type="KEGG" id="tve:TRV_03567"/>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="44103" checksum="147069F40BC9E5A3" modified="2010-05-18" version="1">MPSIISKLHTLKVRQLQKLALSIGILSSGTKVDLVNRLSETLHTYDHQARGKNGFGSSHCSTETKLQTPNGPGPMSILSIDMGIRNLAYAHLLVSPAVQASDVRTIESVYQPLSAAKISLNAWDRLAISSFPTCDIHKDPSTMTISKLGGLRKAIFQPSSNPQDEEGQPEKESKEHFAPYLYASHAYTLITSLLEAYKPTHVLIERQRFRSGGGSAVQEWTIRVGVFEGMLYAVLHTLQQQGKGEFGRLFVQGVDPQRVVRYWTNDEVKDTTPDSKKRVSSKEGKRAKIDLIGRCLSRCVGVGDFDKSSKHEIPLELGLVEGSQAKDIVQAYLDRWNAGGRTAKRCNDIRASMEQSNGRVENIGKLDDLADSLLQGITWLEWQKMTEKLLYSNAVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D913</accession>
    <name>D4D913_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022279.1">
        <property type="nucleotide sequence ID" value="XM_003022233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D913"/>
    <dbReference type="GeneID" id="9576881"/>
    <dbReference type="KEGG" id="tve:TRV_03601"/>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="424" mass="47544" checksum="6402CEB41477263E" modified="2010-05-18" version="1">MYMSMLGLAAFLDWQGGLKTVQGIICFGIGAMVGWPFAGALAIPFLLEEIAVAWSLGDIAPAIKRVLEGVVKCLLILSVVVLVDSIFYRQFALVPWNIVAYNVFGGSGKGPNIFGTEPWTFYFKNILLNFNMWAVLALSSIPLLVLQALFRPHKTSAQTLFRSVTLVMPFYMWFAIFTLQPHKEERFMYPAYPFLALNASISLHIVLAYIGSSDPGTLVGKIPAKVKLIITVIPVLLAINIGLLRTVGMVTAYSASLQVFDALLQTDGAPPEGFVCYGKEWYRYPSSFFLPNNNLRAKFVQSEFRGLLPGEFAESGAGLGYFPGTWTVPKGMNDRNLEDPEKYTDISQCTYLVDSYFPGDKETKPEPHYILDTEMWEKVSCKPFLDTRRTGVLGRTIWIPNLPFIPNKYQRVWGEYCLLKRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D975</accession>
    <name>D4D975_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000187">
        <property type="protein sequence ID" value="EFE41596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022214.1">
        <property type="nucleotide sequence ID" value="XM_003022168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D975"/>
    <dbReference type="GeneID" id="9579099"/>
    <dbReference type="KEGG" id="tve:TRV_03665"/>
    <dbReference type="HOGENOM" id="CLU_2170451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="110" mass="12427" checksum="95B45BAFC80DCEB7" modified="2010-05-18" version="1">MGMRTGKATDIDVPSRATISVNTDSVRKMSHVRLEGRNSSTSVCELAEEEPPDCCWPFWPPPSTAVLMLARLISALIERGYIVARNSQTSQQDMNYIYIYVYIYVYLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9N5</accession>
    <name>D4D9N5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022087.1">
        <property type="nucleotide sequence ID" value="XM_003022041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9N5"/>
    <dbReference type="GeneID" id="9578971"/>
    <dbReference type="KEGG" id="tve:TRV_03828"/>
    <dbReference type="HOGENOM" id="CLU_1929118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="131" mass="14433" checksum="557DC9D067008FA5" modified="2010-05-18" version="1">MGCSISISVSIFISISISIYLSISIMQMEKDRDKGFSSLLFFYSSSSSSLITSSPTYILSLYISSLVSRQLRVTVSPLTACCLSQGLLVDRWQSQQSTLEQHQPSAISHQLSAISRESAPPPPPGYCYHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y0</accession>
    <name>D4D9Y0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021975.1">
        <property type="nucleotide sequence ID" value="XM_003021929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y0"/>
    <dbReference type="GeneID" id="9578848"/>
    <dbReference type="KEGG" id="tve:TRV_03923"/>
    <dbReference type="HOGENOM" id="CLU_014926_1_0_1"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="77694" checksum="425D6F44D7C1A239" modified="2010-05-18" version="1">MDDDVDSAERDLDKGDSSFHKLGKGIVTFVRATLGLEQDIMRQAASRLMDAETSAYNDQHKAQHNANAVNAYHSTIYAPGTEYLLCQCMAQLMAALVGVLSESFSESIKAFYKLRKAYIALDSIAQMEEKYLKENNLRLGVDSRFESANGSPVPGRSARTVDSSSQAEPKPEAKAPLPRSMSATSLEEVTNESFQSSQRRLSRLTLGSESDVSKVAEGPQAKLDMDGDVDIFSHPVDHFIHSGTSLCFGMLLLFISMVPPALNRILYIIGFRGDRSRGLRLLWQASQSHTLTGAISALTLLAFYNSFVRAADILPDPVDGNVDDIEGYPMSRLESLLADMRNRFPHSQLWVLEESRMRGANREVEEALRLIRNGKKSPLKQVQALHVFERSIDAMHLHQYELCAESFIECSELNSWSRALYFYIAGAAHVELYRKYLKESPEKAKEHGKKAEELFRKAPSQAGKKKFLARQLPFDVFVTRKVAKWDARAKERNIPFIDAVGVSPIEEMNFFWNGHSRMPDEQLDVALQNLAWSESNETWASEPLDEHSILALLRASLLRAQRKHEEAKTILKSEILCHDRALFKGSNKDDWTCPSAHYEMAANIWMERHCYRPFGRATSIPASDKDDQRKDEATRAAEDERRVQECKEWLEKVYRWETYELDARIGLKVTTAQETITKWEEAHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA67</accession>
    <name>D4DA67_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021836.1">
        <property type="nucleotide sequence ID" value="XM_003021790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA67"/>
    <dbReference type="GeneID" id="9578716"/>
    <dbReference type="KEGG" id="tve:TRV_04011"/>
    <dbReference type="HOGENOM" id="CLU_103887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="26164" checksum="5BC28F37598BFECA" modified="2010-05-18" version="1">MPPRLRAAQRLAKSHHHLLQSSQNTSIYSLTQSTCTSSCRAFSSTPNLQISKRRQAMFGWLNGPGRVFKDPIPSSTNYLTAYEKDGKPKAPQTRVGPDGQMVEVEPSPRPFPHNPVFISESVLSEELRNEIYEQVVNKGKSVKTVSVMFGVDMRRIGAVVRLVELEKRMKAEVSLNSPNLYTLSLHPYLYPYAGTIWSSMMNKSISLDDSKRMIKFCIYSEKTAILYGMAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAX6</accession>
    <name>D4DAX6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021601.1">
        <property type="nucleotide sequence ID" value="XM_003021555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAX6"/>
    <dbReference type="GeneID" id="9578562"/>
    <dbReference type="KEGG" id="tve:TRV_04274"/>
    <dbReference type="HOGENOM" id="CLU_001858_0_0_1"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="685"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121421" checksum="98A60EB4D4F0C27A" modified="2010-05-18" version="1">MVEWLPLKRTTFYGVKPEDEANSAPTSSLLENQPPNNKRPSHSTASADTGSSGSKSISSSNQPTPSVNHTSSTLEVKVPGHPVKRLSLEPLESRKQSQRSSITDERSKGQRKRSKNVSVNSTPTAAANASQSLPSPPALRHRSQKHRRIADGTSKSNAHVSWGDQSTVRWPKPESNGDSPTEPTIDAFFPLDRQGLAPEPKTEESDEGPPVQSLSHLSEEIVDSLEKIMFKTEDDKQVWKSEISQLESMGYSEPWEWKYATHEQRLAFPFIAQSVFYVLGNPRQLLLSFRNSSDGRPTSSRLDIDSLDGTFRKLHRICPWETTLHSLWLSMEKLFNPPAELSLPRMQRRHSKSSSLTTPISPRFEHLGPNDYITDSDAASITVVALLALSSTIPHTDTRTWEAIRHMRASGSVMPDSMMRTFSKLQTQTIIETSDRFEHDLALRLLNRLARVISTRLALHEVSKTKASHLTDFTSNDKCELIEKIIVMLQRFHNPESSGNSNKISLPGDRKTTTPMVVVEWLRSVLLKEWDGKPELSKASAAGGALQLLSFLYRDRTKLGLLPEDFHTPFFADRLDPIDMPTEWVDLLYNNRTMHLLSCSFIFPPSALVTYFRAINHATMSKSFENAVIASKHVTSMAFSGTISVDDNLGLLARLRTGLTMFFVISVRRDHALEDALNQLWRRERRELLRPLKVRMGMDDGEEGVDQGGVQQEFFRIAMLEAMNPAFGMFTVDSRSGTYYFQPCSFEPLYKFELLGLLVSLAIYNGVTLPVDFPIALYRRLLGLKVKTTDHIRVGWPELAKGLDELLAWEDGDVGDIFMRTYEFSFSAFGTVITVDMERTDKNEPWPAPERYAQWEKTKQKLNDQRVATRRLSNQNGPDGSNSVSMLKEYSTDSRQHPRDTHVIGILKGAPSRLPRHQVSTEPQPGASTVTNANRKQFVKDYIFWLTDKSVRPQYEAFQRGFFTCLDRTALSIFNPEALKTVLEGIQEIDLAELQRHARYEGGWDGNHPIVKGFWRAVLRYPLEKRRRLLEFVTASDRVPVNGIGSILFVIQRNGVGDSVCYNPSILTKLSKTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB38</accession>
    <name>D4DB38_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021490.1">
        <property type="nucleotide sequence ID" value="XM_003021444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB38"/>
    <dbReference type="GeneID" id="9578471"/>
    <dbReference type="KEGG" id="tve:TRV_04337"/>
    <dbReference type="HOGENOM" id="CLU_1103442_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27498" checksum="ECB61EB60F2A0257" modified="2010-05-18" version="1">MHSCTESEPPKTHGRDENTRPDSFSLAQLNANSNTLPAQDGQSTATHDIKLDKDDDDGLTGPLDNLRLSKDEEGRPIPETAGGAQEDGQPRTDSLFDDDQTHLSNSSTKPTSFDSKSMASVTTFAMDEKESLRPDDSASVQAVEEDEFLAPTTDAISSQANSDPSASNRGDSQQHKNSILREPELLKKSTLPFNEDALRRNGVLPAPEGEQVLHGFPSEPDEKLVEAMGSPKDRLLLLQLEDKIISFIKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB59</accession>
    <name>D4DB59_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021511.1">
        <property type="nucleotide sequence ID" value="XM_003021465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB59"/>
    <dbReference type="GeneID" id="9578459"/>
    <dbReference type="KEGG" id="tve:TRV_04358"/>
    <dbReference type="HOGENOM" id="CLU_037358_0_1_1"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055452" description="PLC-like phosphodiesterase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47951" checksum="8FA54CBF0A6EE520" modified="2010-05-18" version="1">MEIVLFVLGAVVAGLLCPVQTAAEATITLTGSDIPTSISIHHGTRTSTSSGELSQSMFSSSSTNSSDSFYTTTSASYTLLVGSHTTSTVTANETTLSGNATATETSREPQPTNTRPCNGYAEFCARSYGNITQVAAHNSPFVRPGNIASNQELDVVTQLNDGIRMLQFQTHLVNGTIYLCHSSCDLLNAGTLESYLKKVAEWLRDNPYDVVSLLIGNGDFVGVKNFTAPIQSSGLIDHVYTPKNHSIALDDWPTLSEVILSGKRAMVFMDYEANHGEVPYILDEFTYIWETPFSPTDRNFPCDIQRPPGLNEADARKRMYMANHNLNLEISIAGATILVPNTVLLNETNAVSGFGSMGAMAGNCTEKWNRPPNFLLVDYYNIGNVNGSVFQVAAKLNNVTYNGKCCGRTTSLASESVLARLSGKLEMIYLMIVINILVMTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB65</accession>
    <name>D4DB65_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021517.1">
        <property type="nucleotide sequence ID" value="XM_003021471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB65"/>
    <dbReference type="GeneID" id="9578478"/>
    <dbReference type="KEGG" id="tve:TRV_04364"/>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="545"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118634" checksum="533CFE976662C924" modified="2010-05-18" version="1">MDTYSSAMARGATPRRSPGSEQGHYSKTSPSSSGSVLGSGDASQAPGARVSSASKASSTRSNADKQLSQIEKSVTHLLVATKQLLEMLTQWSRKQAKETEVSDVYVRLGYEFNLACRAFSAIGMDTADLGPVPDLLRTILEDTLSQDASPQSLDRYLPKIRDIIINLLHGLKRKQAKLRSRQAKEGKALPPRQGSSGSFELGDGTPHQQGLEHSSSTATQSPQKRSMGSHRQVGGPYDEDQVSVSSRTKSPSPWPGDRPAGASFSEREAGRQEAQRSLVQSSATTSSSLSSFTMQNMPVVPPHGDPETQQQQQPKRPESPSYNANNFPHPPPPLPPTSKQNDAIGMLQRSGELERRASRRFSAYQIQKHLGGSPSGIPVLPPAQNSPIPNRGQDVRESMNAVRLRGPHLHDRQRSRNRLAGASLDKTASPASHDAAAAHIKLDPNAAESVASSPLARTPTDKLRSQREFDSPSAPGSSLPGGLPQIAEQDSLSPPQEHRKADGHAPIPRSHLDKPLPSPSTPLQSHRPDYTPEHSPPPTKDLTLFLQYKSKIKKYVLPEGYSGLTIARLQLAFIEKFAWNTHSNGADLPEIYIQDPVSGIRHELEDLRDVKDRSVLVLNVEVLDEVRKHFDESVGGIRSIVESVRDVIDGHGTSIQRLIDRQQETSKEISRLATPASISAALPGSRPVAGGAGGKTAEIQALRDDLASLRQTYSTFSSDITSSMANIRAKAKQVKSAAVDAVVPSFEGGSGAGHARVQAGKKELADESEKLVARVDDLQDLVEDLRKDVVTRGVRPLPRQLEAVGRDISAVTKELKKMQDFLKREKPIWTKIWEKELQLVCEERDQLTMQEDLAVDLEDDLEKATQTFALVEQATKQQALESSGSNPNNIAVRNVSRTLNPNIDPADAKDSVLGEVRALQPNHESRLEAIERAEKARQKELESRRGGEFQKELSNFVGANKLKSTGGFEELERVRKEKEESIRREVWERMQGLLPAEPEMIAANGENEEPEQLESNSADDQHTPPNDDVEENNDAPDTNDDAAHAGGKRDSTGNQSDRRSSGHRLSDTPVSSGKKRSSWLTAIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBB7</accession>
    <name>D4DBB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000221">
        <property type="protein sequence ID" value="EFE40857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021475.1">
        <property type="nucleotide sequence ID" value="XM_003021429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBB7"/>
    <dbReference type="GeneID" id="9578436"/>
    <dbReference type="KEGG" id="tve:TRV_04416"/>
    <dbReference type="HOGENOM" id="CLU_042538_3_2_1"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="389" mass="44815" checksum="53A017C6B7B50594" modified="2010-05-18" version="1">MEMNPLELGRISIFPSIHPQSCFPILLRFLTGAIRAPDKSHYKKGALYKAATAPETLLPHQGFRNSLKGQEASIPSLYSLFPEWSPKLHEEYERARDEVINPWLDIWVDDPQTCMKLKKADFTIFAAIVCADVSFDKLCTVAKSFAWYFIWEDPSYLKKSKEYFQHQLLEIGEQPDLSRFSQEQQKALLCWDEVGQHIRETCSKNFGSDSDREDYSDVREVFLDKMLRYVASVDTIDSIFQEGKVPSLAEYWQRRNLTAGVYPVLATLPFAYDIDISMEHLKDPAFAALWRQTSYVVHITNDMLSMRKEARDNQIENLIPVIMMNYGLDCDTAMQTSFQMAKDEVKGIRVVERMFQKGGENNNLEIPESLAVSFTKGCKDVAMGLIHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC5</accession>
    <name>D4DBC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="12">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_04424</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021451.1">
        <property type="nucleotide sequence ID" value="XM_003021405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC5"/>
    <dbReference type="GeneID" id="9578412"/>
    <dbReference type="KEGG" id="tve:TRV_04424"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_1"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000071">
        <property type="entry name" value="2-hydroxyphytanoyl-CoA lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="18">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="16">
        <location>
            <begin position="196"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="17">
        <location>
            <begin position="401"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="608" mass="64876" checksum="21603ED6053DC0B6" modified="2010-05-18" version="1">MSQPTGAQAVARALKNLGVTVIFGLVGIPVIEIAEEAINLGIRFIAFRNEQACSYAASAYGYITGKPGVCLVVGGPGVLHAMAGIGNSNVNAFPMLILAGSAETTLVTKGGFQEMDAISLLTPHTKLAIRPISVDYAENAVYDAYRTCWYGRPGTAFVDLPADLIQGKATGSLPSAGLQLVHAPPKPAGDPSIIFKVAQLLRSARAPLVVVGKGSAYARAEESIRKLIDTARLPFLPTPMGKGVVPDSHPLNTSSARSVALKNADVVLLLGGRLNWILHFGEAPRWSPDVKIIQVDIHAEEIGRNSGSGELGIVGDIELVVDQLLKSLGDWHYQPPNSPSSYPSLISASATKNENKSQEKALQATAAGQYLTFQRAFHIIKTTLNSLSPPENGGIVYISEGANTMDISRSAFPLQHPRQRLDAGTYATMGVGLGYIIAAHAAYNLPQPQGTLEAPSPKKIVALEGDSAFGFSAMEVETLARHQIPALIFVMNNSGIYHGDTKTEDDWRNMQQATLSNETTSSSAGDKKGLRSTSLSYETRYDRLASVCGGQGFFVRNEKELEDATRAGFLEKHKFTIVNVIVEPGIGQSIEFGWQAGKKDKAAQASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK2</accession>
    <name>D4DBK2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021428.1">
        <property type="nucleotide sequence ID" value="XM_003021382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK2"/>
    <dbReference type="GeneID" id="9578388"/>
    <dbReference type="KEGG" id="tve:TRV_04502"/>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000026">
        <property type="entry name" value="Gamma-cysteine synthetase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="372" mass="40958" checksum="320E06AB96043476" modified="2010-05-18" version="1">MTSRITNAREGFCFHGVRVPFEPGCCLSGAGCLYRRVHLATFVAGEHTQGRTDSDTPAKMRLILSTGNIVSSGPSVLRRPATEKSNVEFLNSLRYNFVSAQEIEPSHTNSPCEETHSPPQKLSYSDYTTWTSRDGDTLYVPSLDFSMSGLSEDRSQYDVTVKLFYLPGVPAQRRCQHARESIDLVLKELHISCIDLLIVSFPEVTFDADDEGEEELSNGEENGSELDNIVKTWRALEAMHEQGIIAQLGIAEFDSSRLAKLLAQTKIRPSVDQINVKDCCVVPKSLILYAKQENIELLTHNDCTDILPRGTTRDLLSRTEKGAGILAATAGADDGGIKGDVDPQWVIKYTAVVKDRGVIENKGYFALADVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBP7</accession>
    <name>D4DBP7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021341.1">
        <property type="nucleotide sequence ID" value="XM_003021295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBP7"/>
    <dbReference type="GeneID" id="9578232"/>
    <dbReference type="KEGG" id="tve:TRV_04548"/>
    <dbReference type="HOGENOM" id="CLU_049749_2_1_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28783" checksum="DB7719579B9BD0D1" modified="2010-05-18" version="1">MDAKPVAAWDQLAETWDTLMGTPGNDYYTVIELPALERLVQPNPGDCALDLATGNGLVAHWMAQKGTSVLATDGSPAMVAKAQARQSKRLEENGEVKVSYQILDVTDPQHFDELIQSRGLGAGGAFDIITMNMAIMDVSTLEHLANALPKLLKRDGAVEYKDNPESGREEVFHSLKMTKYLHVPPYKGVATQSQPHPQLYFHRPMHEIFAPFFKAGLVLDALEEPNFDEAYVKARDLDIGSLRQFTQFPKILAFRMKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBQ5</accession>
    <name>D4DBQ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021349.1">
        <property type="nucleotide sequence ID" value="XM_003021303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBQ5"/>
    <dbReference type="GeneID" id="9578181"/>
    <dbReference type="KEGG" id="tve:TRV_04556"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="344" mass="38531" checksum="8021C087F1246765" modified="2010-05-18" version="1">MLMSGPGYLGTTVLVFAWFLAAVAIGVVGTRLYVRWRIVGKYTVDDGLILIALVSLTGILLKTQNGTKLSKKQIKYTVKWVYLCEFFSIMSPGVSRIAYASLLLGILPPIKWRSRMLWTLIWIQFVVDVGTVIISFVQCRPINKFWDSSVPGHCWAPTVQQYAGFFQGTRLLITITSYVDNADWIINRTKSAMIASIIKTVQLQAITAKADITYAMAHLATWWTLEAYLVIIATSIPTLRPIMSTNRQRDKSNKRSNISDSHQASYVHSKQFESSDDPKLLDRSCGSRNSTPNNGEVYLMEEGHRQDGYSSEGVDGIKKETTIGVTYETATRKDQRASMGVGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC75</accession>
    <name>D4DC75_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000238">
        <property type="protein sequence ID" value="EFE40544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021162.1">
        <property type="nucleotide sequence ID" value="XM_003021116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC75"/>
    <dbReference type="GeneID" id="9578010"/>
    <dbReference type="KEGG" id="tve:TRV_04727"/>
    <dbReference type="HOGENOM" id="CLU_007078_2_2_1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="415"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="694"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="897" mass="97490" checksum="9795E2C02DF1C1DF" modified="2010-05-18" version="1">MADWPRQPKHFPNSNPFTSSNYAAPNSERRPQQEPSPKTSPRLGPAIHVRDMSNTSDSSETRGRPSHRVQFTLGSDGSDASPEDIPLRDYMDNSPPSEPQVPAFVHRPSLPTFKSSDFLPMYNTRDSLSAQSSPGASPIVTPLGSPGRPPDSISEAQSTESSKTKNRAIQTAYEKAQSLASQVRRASYFHRRRRSDEESLSQDLIEPRHEGRHYLRRSRTGSKTAYEHEHDRERQFTLRAEEASEIVKNIRAKAEPKDRRHYSIDTQSSGSQSPPVQHGRSILTDILRLGQLHEAEANRTSQQQVPTSQANASPLLAPHSAPTSGKTTPGKSTPRPKWYEKNKNPSALSLNTLGSEATLTGGGSGAGSAGRPELKRSRSSGLMVNAVKKICNKPRLEDEIRLTVHIAETISRQRYLEKLCEALMAYGAPTHRLEECLRMTSRVLELDAQFLYLPGCMFVSFNDSSTHTTSLKLQRCDQGVDLGKLQDVHQIYKDVVHDMIGVEEAMQLLEEVKTEKPRYNVLTLIFLFGLASAAVGPFAFTGRVIDLPVSFALGCILGALKYIAVPRSRLYANIFELTAALLLSFLSRAIGSIRHGPGDDRLFCFPALAQSSIALILPGFMVLCSSLELQSQNILAGSVRLVYAIIYSLVLGFGMMLGTTFYGKIDHNASSAYICPTSPNRNEYAHNFPSVIAFTICLTLINQAKWKQVPVMAIFSFIGYLVNFFTSKAFPHNLQIANCMGAFAIGIMGNLYSRLGHGLAAAAMLPGILVQVPSGLAASGSLVSGLAFANQANSAGQQTAANQTMSTASSTIASATSAATTAIASALAGHPGGSGYPGDPAFQDLAARIGTNKVYGDVVFDLAYAMIQVSISTTVGLFLAALIIYPEGKRRSELFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCM4</accession>
    <name>D4DCM4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021014.1">
        <property type="nucleotide sequence ID" value="XM_003020968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCM4"/>
    <dbReference type="GeneID" id="9577866"/>
    <dbReference type="KEGG" id="tve:TRV_04879"/>
    <dbReference type="HOGENOM" id="CLU_007784_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="437"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="975" mass="106153" checksum="298C13C14211A96C" modified="2010-05-18" version="1">MPCPSLLYSCHPLYSSPSPSPPSTTVYCLPLSTTVYYCLLLTASYFCCFFCFSFSCSSSMTKLAPSPATKLRLQHRRDKDEDADEEEEDEDDDEEEEEEEPPCPPHDINTSINTQDAILTAAYRYQGEAVYLADRRAAGAAAGSAVSTSVTSTATATPVPAATVAAVPVSVPVPGTAATGPGPGTGTGTGTADHLNPSWGYDLNLLSHAASHVALEGQGHGHGHGQPQLQVHGQGQLQVQQQQHDRKVAPVYERPISENYGVEPSILDLADLGDPVQDFTTFLESVGLSSDWDSGLFNSVEPEPLLPTPIPALDGSTKQQSFGTAPRFTQELDSRNVAQLAQTTTTPTGPAAAAAAAAADEAPSFSNFGSRLPSLQPEAQDSDAGTSEHNSQPRPAWDISTQEHQLFTARLEDFAHVLPKNFVRPSRHALSRYMAGYISGLNEHLPFIHVPTLSVARCPPELTLALAAAGSHYRFENSRGIELFHAAKAILLERLRRRDSRRTTTLPPNPQWAPNSTPRASSSVVSNPSNSPFPQQQFISFMDNTSLPGEDAEGQMEIIRTFLLLTIFASWESHPDILRDMLALQSTLARLVRDHGLKESPATTTPPESLSWPDWSRLEADRRTKLVVYCFFNLHSIMYNIPPLILNSELNLNMPCSADEWKANTASQWRRVRRPSSDTNTTPTPSSFQDALANLFTKSAAAAAAGTTTPPPPNPVSPLGNYVLIHAIIQQIFFARQLCLSAPSMAGTSLRPDDLAVMGNSLSAWKRGWRQTPESSIDPQNPAGPIAFTSTALLGLAYIRLHLDLGPCRRLVTQDPVQIAHALNDSPPLTRSSRLIMALLHSAHALSIPVRLGIDFVARTHSFFWSIQHSICSLECAFLLSRWLLSIPATQHDQGLSDHERKLLLWVKGMIDETDMSSSISAATEAELITDPALMRRLSVAVVRVWSRTFKGNTSWPIVDLIGASLEIYADLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCN6</accession>
    <name>D4DCN6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 family helicase/ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04891</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021026.1">
        <property type="nucleotide sequence ID" value="XM_003020980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576673"/>
    <dbReference type="KEGG" id="tve:TRV_04891"/>
    <dbReference type="HOGENOM" id="CLU_001161_0_0_1"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1912"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="907"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1596"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1604"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1624"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1656"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1669"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1688"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1705"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1754"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1766"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1834"/>
            <end position="1850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1932" mass="216872" checksum="1ED8D77879CCB3AB" modified="2010-05-18" version="1">MEADPFFWSIDEVVAYLCHGSFNDWARSSLPRPDPIQLEGHLRENYVTGEVLLTEVDREALPRYLGLKALGHQATIFKAIQYLRSRSSEFRNGVNNDFSNTQNAVVTSPARVDTFPGPPVAENRSIPTPLRSSPQSQAPLAQLATPQPAESTLKLVDPPAPQQKERDARKRRRLNPDALSTQLLANVPENPHRKRYLCFQKHPVKDVFYKGIDSDDDNDTFGYVRPANCSTGESRFINRRILHFLQQVPQPFPEDKEGSLAIFPYDENVAPDVPRYFTLYNKNNGRVSVRMEEVSKWPHLREKSPLDYLAVKYPPQSDELPLYGESGSEDYDSETCRDMDEARDDAKSDNEDVASSLMSAADLNAIIDQFITDTIEKWRNTKLPIYERTAYALWNKSRKKGTVSSDIRRAKVQITHFDKRLASWIKGIKSNEYETGDRGKVLRQCASLEVTVTQREIQKWRVSVLELETCPSKPSAPPARPTASRPRFRDNDEESIGSDTDEAVESDPDFVVSDDNPMNTQGTISPERNRNVVPSPSSILEKENTNPLPDSAAQIPIRGPFEDVDVLDLTEADIEGEQEIEDADGSGSLDIHTPPLNPTGSSKDGLVFSPPPPPALPNPVRDRSPSDDESSRQPDITDVTALNKIDWETVIERGDRRLLLAKIIYTLSKDERAKLTALLGSVEKNTWRRRLREALKAIQKKGYKITSIPGEDVYLYKRMATLYVSWFKVVLIRGNVGIPTAYLREARRKDEVFPYYNDLTEILCVENRKSIKRETSCEIINSSQNTLRNGSSVVTDPIIIIDDDDEEEPSGREAQTQEIVRSTPRKKRKRAVAESREAMETQSRAQRRVEEQATRQRILQEEGGIENDDPEKKIISFDDPVICLHRDLGRRIKEHQLSGIQFMWRELIKDEKNEGCLLAHTMGLGKTMQVISLLVTIANASNSSDPKIKEQIPRRFRTSRTLITCPASLIDNWEEEFAKWTPPDAVTRDNLGRVRKAISQDPIQRLRTINAWYTEGGVLLISHELLRRMILYNPQKTGLQRLSTEQCEMLKGQLLDGPNIVVADEAHKMKNGASNLSKACSMFKSKSRIALTGSPLSNQLIDYYQMVNWISPNYLGTLKQFKAKYEEPIREGLYYDSTNAEYVKSRKKLEVLKKVLEPKVNRAGISVLQKDLPSKFEFVIYIPPTPLQKETYNQFVALTMEGKGEFEFTRLWVLLSYLTLLCHHPSCFLRRILEKKKARSQVIEREKAIEGGPGVVVPSESEPEANVDDSSILITVEDDVLEIEGQTAITDEVVSQFEQKFKDIKDLDSPENSHRTQMVGQIVDESIKAGDKILIFSGYLHTLSYLGSMLEARGHKYCRLDGKTPIATRQAATRDFTDSDAHVYLISTKAGALGLNIIGANRVIIFESEYNPTWEEQAIGRAYRLGQTKDVFVYRFVMGGTFEELIHEKGVFKKNMALRAIDKKNPTRSTGKSTSEFRRPIQSCKKHDLSEFQGKDPKVLDKILAQTNFIHRIVTSENLHREDGVQFTPEEKNEIQAELDDERLERSNPELWAKKQHERRIAQEKRIQEDMMKVLQSRFPVNNSLQSRPGHYSVPMQQAAPFNHNGNSVINTQNMRPPWPPASHSPQLHLQPQTAPVTHSSNGVMNTQNTLPSGPALPRSPQLQSQPQTGPVSHNSNGVMITPNMAIPRPPVPRSPQPQPQLQVASQAPNQMQSPSQISASSQGRSETVSPQAPPTQSRPVQGPASAPVYSVPPTLPTPQAPVPAPRAQDPATSICRAPSDPSTPTLAPAAASVSQASPVSQQTQQPISPSSVSSANRGNLGEKATQPRSTQPSPLPPLVTQPVPEPRPSSPEMIHAGIRETFGSFFLSHERTLLAPSDIESVSRSARPPPAVLELKFAPPVASLRSLASKVFFFPLSLSYICAAFLHMAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCR1</accession>
    <name>D4DCR1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021051.1">
        <property type="nucleotide sequence ID" value="XM_003021005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCR1"/>
    <dbReference type="GeneID" id="9576698"/>
    <dbReference type="KEGG" id="tve:TRV_04916"/>
    <dbReference type="HOGENOM" id="CLU_030582_1_0_1"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="536" mass="58072" checksum="B6D5C5699CA22AED" modified="2010-05-18" version="1">MDTWKKQVGEKTPETSRNPSPDRLQQRLNRIFDESRTNNSQPSKGQQETAWSATVRAATYSAEGGRSLPSSPTKPSRLRPQEDRPHSSSQSIAASHRRAKTDLPGLVNGPSFPIHGIRTTSHYADTDPSKLVDVDLGASTEKANEPKSNRSSRLSSGLFQGESTPMRLGLISSPRSDRGASDDIMHDTSPSLERSSRNSSPSSPTKLSGNMNVSASLRQVASGNPFSFFTSKSQQAQRESLPELANDKLLNLDIKSILCHPSFADLPPEEALHSFRANAENLLREFQESYKLRTFALHGAVAEKNAQEDELEDAQSRIKNIKSQLDGMAARVVEQDKALKALTEELKAERQKYQDEIKTKQQQQQKQPEDAATPTRHSKGTHSKNSSGVTITSDSGFDSGDESIAESVFSRENDDGASVNTRFSAVSMASPSATATQPSPAVSAPTSSPSTPKAAQPAPQRESAYGRVLKGISSSALGTSFNALTSSRLKCPDCRANGSSDASTVTSILREENRYLKNRIIDLENAVEECISLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCT2</accession>
    <name>D4DCT2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020943.1">
        <property type="nucleotide sequence ID" value="XM_003020897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCT2"/>
    <dbReference type="GeneID" id="9577793"/>
    <dbReference type="KEGG" id="tve:TRV_04937"/>
    <dbReference type="HOGENOM" id="CLU_051542_0_1_1"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="269" mass="31130" checksum="9AE5C3A482D7FEAC" modified="2010-05-18" version="1">MAIDTSVWYKPLIGRRLKAPTRYVFEKWSGVSGKELIAHLHSIRDKAWPLGEYPCVGEWIFLLPSISAFKQFPEIVHRAKKGATILDIGCCFGQDLRRLAAYGAPTESMYALDINSSLWDLGYELFKDADRMKATFLEGDFLQDNSALSCLDGKTDVIIACQFLHLFGWENQIKAMKRVVTLSRLGTMLIGYQQARLQAREYIRPWGMMFYHNVESFHEMWEIVQQETGTRWSVTAQLVDLHEWGMEDEDVEWMPQDRMGINFVATREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD37</accession>
    <name>D4DD37_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020818.1">
        <property type="nucleotide sequence ID" value="XM_003020772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD37"/>
    <dbReference type="GeneID" id="9577605"/>
    <dbReference type="KEGG" id="tve:TRV_05044"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="331" mass="35918" checksum="A8F8D0E5129F3134" modified="2010-05-18" version="1">MASVTPVPKTGRSVNQDVPASTLTLQTRPTPVPNFDEGEHLIRVHATALCAGELYWHTYVTFTKEETVPGPDVAGTVVLAPPSSPFKPGDDVYCRIPYSRPGGARDHTIALTSELARKPKNLTWEEAATVPLSALTAWQALFDQSGLWEGPEDERVKGKRVAVTAASGAVGMWILQFARIAGFEAVIGTCGDGNEDFVKSMGATDAVNYKTTSLTAWAAEKQGRKADLVIDCFGGKSLADAWGCVKDGGVLISMVGYPEQEKPAGLEVKDVKSHFFIMEPRGDQLQKVTELVEQGKCSFLMDSVYLLEQFQEATDKVESRRVRGKVVLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD44</accession>
    <name>D4DD44_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020825.1">
        <property type="nucleotide sequence ID" value="XM_003020779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD44"/>
    <dbReference type="GeneID" id="9577596"/>
    <dbReference type="KEGG" id="tve:TRV_05051"/>
    <dbReference type="HOGENOM" id="CLU_020030_3_0_1"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44339" checksum="9E8F58789BA2FFE0" modified="2010-05-18" version="1">MMGKSFHVPDQAAASTAASGNQELCLPRKYRFVPSNMPDGEAEAEAEAEASDDEGEASVSINPCLVDPLFQDLDRASRFYISHFTDQMCRDLVTYDVPRHNPYRGIVPLIRDHALLLHVIVANSAIHISNVMSKGPGLLNGVPGQYPHHDALMAKQKTLRLLNQAMNDIDAVDPEVVLTAILLSINYELVSSGKDDWKVHVEGAQKLIDYFGLSKRSDLSSAMSALRDHVVSDCLIYYILGSTFSARQPNMGSTTSRYPFLDVLPLLERAEANSYMSCPAFLLQIMLSASHLSNLDMITGFEEEQARYLMERARTFNIDAWAASVQGISSHNDFESRVHVASAHKSAVCLYIHQAVPSANLMDDDSRKRTVEDIIGHLSFILPGNLLLKGTSWPTFIAGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDV2</accession>
    <name>D4DDV2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020594.1">
        <property type="nucleotide sequence ID" value="XM_003020548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDV2"/>
    <dbReference type="GeneID" id="9577293"/>
    <dbReference type="KEGG" id="tve:TRV_05316"/>
    <dbReference type="HOGENOM" id="CLU_030042_0_0_1"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="52767" checksum="06DE212F1B416383" modified="2010-05-18" version="1">MTSSPSYVDYETFLDPSFSPTSFAQTLVATTNNPSDTPLDLSTPLSRVLFDIQEVDSHVHTLTTKSALPLLRYTTDTTASGQRVLLALEAQVLALTEGYQRLEKDVVRRWEGADEVRGAAERSWATVKLARAVSRCLMLGRQLEGQLVEISGRDREDHRALVRASQTLLMLRRMFADNSNGGDDGEGEGYGAALERVKVVRTLKAELVNPAENSVKARAQQIVSRFTLPTDEQGVVLRPGAGGTGSTYAQQEENRARLISAMTALYLLSPTTTQTISAANFQPELLLVTLKSFIHSSLTASLQALLRGLSQLPSLERALLEVSNRCQTVVVLERILQGARQPAHPFYNRAANDPSSSSSSTLPTSTSEKKEKHVKNNLLYPLLQYLDTTSLPSYFWRCLASALSPRVGELLNRGGAAARALRGNRERLRDEIRQCVLRGSSAGSASRERDRDREQEADGGGLVVGNWEREAAVMVGAVLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEB4</accession>
    <name>D4DEB4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020422.1">
        <property type="nucleotide sequence ID" value="XM_003020376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEB4"/>
    <dbReference type="GeneID" id="9584161"/>
    <dbReference type="KEGG" id="tve:TRV_05481"/>
    <dbReference type="HOGENOM" id="CLU_2529102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="84" mass="10156" checksum="3842FA86D3C80E55" modified="2010-05-18" version="1">MAGRDREWHVILFDINIDVDDRDEMDDMDDMDDMDDMDDMDKIRRRRVEEKTNEDVNTGRGERREEQRGKRSEDEDLDHQTLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC8</accession>
    <name>D4DEC8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020377.1">
        <property type="nucleotide sequence ID" value="XM_003020331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC8"/>
    <dbReference type="GeneID" id="9584136"/>
    <dbReference type="KEGG" id="tve:TRV_05495"/>
    <dbReference type="HOGENOM" id="CLU_2098608_0_0_1"/>
    <dbReference type="OrthoDB" id="4205265at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="116" mass="12284" checksum="6C579D7FE78ECF8E" modified="2010-05-18" version="1">MFRCWWKRIQRYADGQGTISNILLFSLFKHRGTLQKKFNAAVVLVSLIACASAAPTATTTPAPQTPNEKPNDPDIVFALSPANDCGDSNFTNGSSPASPLAADCLKIASNIAADGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEE4</accession>
    <name>D4DEE4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020393.1">
        <property type="nucleotide sequence ID" value="XM_003020347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEE4"/>
    <dbReference type="GeneID" id="9584119"/>
    <dbReference type="KEGG" id="tve:TRV_05511"/>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="165"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="434" mass="47785" checksum="D40FA695D8D22937" modified="2010-05-18" version="1">MGLWIAEQLKTLGAEVELRELGKEPGREHLDLPPVVLARYGSDPKKRTVLVYGHYDVQPAQKEDGWATEPFDLTVDEQGRMFGRGSTDDKGPVLGWINIIDAHKQAGVEFPVNLLCCFEGMEEFGSLGLEEFVKAEGPKYFKDADAVCISDNYWLGTEKPCLTYGLRGCNYYSITVSGPGQDLHSGVFGGTAHEPMTDLVILLSKLVDCQGNILIPGIKELIAPVTDDEQSLYDAITYSMDDFHTSLGSNTSIMPTKETTLMRRWRFPSLSVHGVEGAYSAPGCKTVIPAKVIGKFSIRTVPNMGSEDVTRLVTEFVNAEAAKLQTKNTIKVELMHDGKWWVASPKHWNFAAASKAVKQVFGVDPDMTREGGSIPITLTFEEATGKNVLLLPMGSSTDMPHSINEKLDTRNYIEGTKLLGAYLHYVAEEPMNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEF1</accession>
    <name>D4DEF1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020400.1">
        <property type="nucleotide sequence ID" value="XM_003020354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEF1"/>
    <dbReference type="GeneID" id="9584126"/>
    <dbReference type="KEGG" id="tve:TRV_05518"/>
    <dbReference type="HOGENOM" id="CLU_018316_3_1_1"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000010">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF29">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="132"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="514" mass="57682" checksum="768B485C33BAEA44" modified="2010-05-18" version="1">MSVAGGRVSRQTLVFASASSSSSGSLEAVLMLGSNFLLFIFLQPRLGLARSRAKVSSAKASKTTLRGERRKGERAESVRAGRCEMGAPKKTATLDEGRDKGGRVRMAGGQKKDAAEDGLTPLTSEERDSWNGFCEIENEPALFNAILKDIGVKGVKVQEVVSLDEEMLAFLPKPIYGLIFLFRWREDDPHKQEQSCPESLWFANQTVENACATVALLNIIYNIEVIEMGEELKSFREFTKDLSPAMRGYAIGNFEFVKKVHNSFARHDRNTTASADQYRKMDILSADMLLKNQQKWKARGNQELDESEAGFHFIAFVKAKERVWKFDGLERQPQSLGKCVEEDWLGLATKEIQTKMAEYEEGDIEFSILSLSKDPMTGYLADLASNVKALQHLNSRLAGFGENCDEADPENAVLCGPDAQYGLTPAMLELALVPSELAETAENGNEAHDLDSLARQRQALVEQQRLLRTQITDEQNSRQIELNYARRRRFDYCAAVNRWSRILVRKRKCEELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEF6</accession>
    <name>D4DEF6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020405.1">
        <property type="nucleotide sequence ID" value="XM_003020359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEF6"/>
    <dbReference type="GeneID" id="9584131"/>
    <dbReference type="KEGG" id="tve:TRV_05523"/>
    <dbReference type="HOGENOM" id="CLU_007254_1_1_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="590"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="633" mass="70677" checksum="EF1FF2D25706209C" modified="2010-05-18" version="1">MADTVEEHYQFTLSQEALNTERHSFERSSRQLRYQTVQFVSGGQKEPNDPAVLRNLDNLVLDRDTTKEDNKEDTRGEDVEVEAVVEVEQVEADKQENKKPEKENQKAGKEEREEKENQKPESREKEEEDLYVIDTEGDKTVKPTLPNPVINCDSSDSSADEVVFTGRVPLWRRQVRSRVVNDPPPAASSTAQRTPPKRSHDAVDRRDTGFRGWSGTSRRRMSPRRVVLEFGNDSADSDAVADYLANLIGDDSSDSSDGWSDDEQPGKAVTPKTPGMSGPDDVDEEEEGSSSGDDDDDDDDEDDEDIDIDSDMQWMSDEQLAHLLDTGDIPDMDADEIDFFTTHGFARSGAAAASGRNKKNKKKDKRKNASLREPISASKLADMFEEDPYGAFDIMDYNRTSLMGKKARGKMPDFDLSDSELESNIHASWENDRRKKKAKKLEREELRAQGLLGKSGKARPRGNTPDDIRDEIRSFMMSRTQTLQLPPMAKKDRKLVHEMANALSLKSISRGKGYDRFPILTKTRGTPTFHPDEVHELEALFSRRKITRYSDRRRAGPSGGARSGRARGETRAASYMDGDVVGASAPEIGADNRGRAMLEKMGWNTGMSLGAADNKGILQPVIHIVKTSKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEJ3</accession>
    <name>D4DEJ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000297">
        <property type="protein sequence ID" value="EFE39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020349.1">
        <property type="nucleotide sequence ID" value="XM_003020303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEJ3"/>
    <dbReference type="GeneID" id="9584087"/>
    <dbReference type="KEGG" id="tve:TRV_05560"/>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="667" mass="71662" checksum="A0BD35EE2D012737" modified="2010-05-18" version="1">METSSTATTATPNSISIMSDAPLATPAGVSTPTDTMSLATPPPTATSQASSTTTTTSSATAATSTSTAATSASMASANATSSDSPAARPASRRPPRKSTLTQQQKNHKRQRATQDQLVTLEMEFKKNPTPTAAVREQIAEDINMTERSVQIWFQNRRAKIKMIAKRGIETGEDCDAVPESMRRYLALQLDPAGSNARNMLGRAGGYPSNEPMMQSATSSKVVIQHFACRSLRIGTWRRVGQNTMDLVIFYSPDQACMTYYINNDSAGYKIEYPFSSIKNIILEPGDPVPPMDGAIPRSGGLVIELNRPPNFYMDSSNSGGFYQCGDFTEEQQATKSLIHHLGGHPKVLSVQLAKLVSLETFQNRHVPAYPFTPNTPFIDGSPQFVHLHRPASQPNHLSRAQNRLSVDNHLSVGLHPNRGHKRQRSRSVPGPVDFAALHAMPAFHFQSANPFQPSTPQHQEHQQPDIFAPVPLAHSQFQLPLNMSEPDLHIDTSATQPPPSFSMYPASATSAAATSTPATDFVSTPLFSSAPDQPQSLGTPFSLPFLSPSPAVDIDIDSDPHSMAHQHQAQAASSNGHSPPLTATQRSSPTNMFASTVTSTGVDDGIILSDLYAKQNLGCSSSIASPGMEMEESFAMTFQGMRGHGHGMMGMGFDSGTVDPSTLAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DES8</accession>
    <name>D4DES8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_05668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000310">
        <property type="protein sequence ID" value="EFE39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020256.1">
        <property type="nucleotide sequence ID" value="XM_003020210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DES8"/>
    <dbReference type="GeneID" id="9582797"/>
    <dbReference type="KEGG" id="tve:TRV_05668"/>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="863"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119755" checksum="85D274B7D5D5C336" modified="2010-05-18" version="1">MNANPMAAAPVPAGTFMAGTKVQVGSHRVVVEKYLSEGGFAHVYVVRLPKPVDGVETAVLKRVAVPDKASLANMRTEVETMKRLKGHKHIVTYIDSHASQLKGGGYEVFLLMEHCAGGGLIDFMNTRLQNRLTEPEILKIFGDVTEGVACMHYLKPPLLHRDLKVENILISGNGPSRCYKLCDFGSAAPPRPAATSAAEGRLIEDDVQRHTTLQYRSPEMIDVYRKQPIDEKSDIWALGVLLYKLCYYTTPFDEGGQMAILNAKFKYPAYPTFSDRLKLLIGMFALSLLMSRYLFKLTLNSFDSATMLKEHPKDRPNIYQVLRETCHMRGKEVPIRDIYSDHSHSEARRSQQLPTSTPVEPPKVGATFTPPIQETKIIPDIAPMRRGRPVKPTDQKAASKPSPSPLRVSGDPFAALDGTKRNVSTDELSSRFPTLDQFSLLHEKGGTFNFESTNTESTANPDDLSKRVTNALADEAFSKPAVSPQPSPTLGMHHTTTRIDPLASDKKLVSSPYLRAEPSRQQVPIQQPTPQKPTMVSTGTMTSPSPVNQRSDSPSLSQRPLHRFPSQSHKKQASGSSRESSGHDHPRVHSGSLSTRPSFARFDSKPIQADDLPRSPASSRPSLEGTRPTASDIADPLTRSKSANSKSRPTAAYVASRLEYLRDRGRERSSDEDETLLRPSVGEHDLEYSQPSNMSDVDFLKAKEEEELSRKREKRLSGGSKHAKRGSLSSLSLSGTKTLLAGRFGDAFRRFENNAPHDRNQTPSPENDTQHLTPITGSEVTELSDDGRGYDNVDTDDISPEMKREMERRRLSMEERRVAEAAAQYRSQLNEREGGPSRAVGLGIGSGGRAAAIENKVQSLLKETEKAPPVKTASGYGRYTDAVPNPQAKRFESPLPERPASSTMQPYTSAPATSHTPDFRSQPSKDKDPPSIGLKYNTGQHQTSSTTSRAAQRPVAPPKPKSLRTGIQSANQTGNSEYNSPQHPRSTRQVSNSSEDWELNFSRRYPSLSGLELVETEIDIPKASLGRTTATTAKSRGTLYRIFMLLVRLFPMSTTLSIYQGKQAPFHFSLVKVLLSLLAVMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEV2</accession>
    <name>D4DEV2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020253.1">
        <property type="nucleotide sequence ID" value="XM_003020207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEV2"/>
    <dbReference type="GeneID" id="9582794"/>
    <dbReference type="KEGG" id="tve:TRV_05692"/>
    <dbReference type="HOGENOM" id="CLU_034664_0_0_1"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="572" mass="64000" checksum="876D0736E114465A" modified="2010-05-18" version="1">MSSNSTSNGPGRWRGGFRGTRRGGRSVRGRSGAGRGGGRQLVADRDLSPKAGAVVQRFRQRQKDLSQIFRKVAAVQKSAVLALASRSEALLIKDPKAHMASSLFNEVLQGLEKKLRKAEDLIEKEYSYRERNLDVWRETEEFRIKTHFENKIDNVMNEHIIAAQGSFMEASEKSRIAADEDHTETEESASEPRTPVSPRFARGFDSSFVRDPEGAALYERVENGWEDLAQRTKIGEEIWPRIVAMSQEAELPAPQDGDGINGRFTNPRFSRLMGALVEACDIAEGKKPKIEEVEEPNPLDALANAALDRGEVKRQPPEPSPKIQQLPPTSALLQPPPNLQAPSQPEQQVQQPQPQYGQMRHEPHRPLLPQPLAPPLYPPSTDMRRYSAPQFAGPPPPHLHPPFQNHPHVHPEGPPQQQLPPVATRSQSQVLPHLSEHLRLPNIFPPRTQHLPPLQEMGYHRPSLPPPPYQAPPPPHQPPPPPPPPPPPNMQPPAHGMPMAYPHHPQNVYPHLQYLPPPPNMQYHPHPPPPPPPPPPPSHQPLHLPPGAHGPQGYHHHHHQAYQQPPPHQPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ1</accession>
    <name>D4DFQ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019956.1">
        <property type="nucleotide sequence ID" value="XM_003019910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ1"/>
    <dbReference type="GeneID" id="9584708"/>
    <dbReference type="KEGG" id="tve:TRV_06002"/>
    <dbReference type="HOGENOM" id="CLU_009138_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="799" mass="88849" checksum="9645E475EBEC38E4" modified="2010-05-18" version="1">MASQCALYRGEDDEDAISLTSTVPSEPQEEYNITGVLAERIADNGATEYLVSWENYPIHRSSWEPAENFGDPETTLREWNQKKEAITKGDAPEFDLIAFENLLAGIEEAKLRRKRKRRLKRMRLGLACGSESGDNNPESHEEDNGDGSSKSSSSDEPTSSRISPASRKRGAGILLPKQELMATRKSSSSAAGSSDAIKGRTFKAALREASQPPRQLKIPPSSKPKVPSTAPPPIKVSEKPGTRLPIRTSSVNVIEPGNEGQTVQSSTANPPTSMAPSRKSVFTFAPATARRGGSMTAAVGSRQPSGPPNNRLFRTLSTQRKYHKMSRTERPPDISQLDLRPPSEWLTAAGRSALREISLGRKRIGATSMSSSIDDLFVAEDDNNGSLPNNPPPVLSKDSNTNADGKSLCTRIWREWNKGDVMVHLVFSAKEKVIGDIRITGLPHSARSWLLSLKQGDQIVIDLQELCSPKGFLQLDIFLGISNLLFLQEPNKVNHGHVIPYNDTMNQVNYLTEYLLNNQSAAIWRSLVWPSRSIIIYPSQAYEWRFLHKQSPSHLSPMLRLVIITLPDTSELRKIPLPSPIPSSSHQTQSDVQPGKGPEEVVLAQGYSEIAVGTATDTPSLVSLQEPPRTITLTLKTPLPPNESTSSPAQHSSRELATKSLPERARDLDVETYFQNHYRITFEYLTRSKYSKYRKETLPVFYLIFPSIEREEHDLIQQLLVFNRIAPYSHRNQGDWTKFIKDVTEAEVKPQGIIIVSKSITSPACLIYVSNKQDAIYSVIRSSMPIIACLNFRNFFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ6</accession>
    <name>D4DFQ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019906.1">
        <property type="nucleotide sequence ID" value="XM_003019860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ6"/>
    <dbReference type="GeneID" id="9584657"/>
    <dbReference type="KEGG" id="tve:TRV_06007"/>
    <dbReference type="HOGENOM" id="CLU_023194_5_2_1"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="349" mass="39086" checksum="A6E38A07DF62094F" modified="2010-05-18" version="1">MALFLQGCEFARQYTSSLFHGRSQPSKRALKLGVLSTAKISAAAVVYPSLSHPDVDLYAIASMDPQMAKTATEKYGFSKSYHSFRELLDDPLINIVHISLPPNIFFEWATNALAAGKHVICEKPSTANADEARTLIDDAERRGLVLQDAFHWQFHPAAHRFKEIVDSKRYGRIIRTDAWMTSSPAVPDADPRWQYDQGGKRTSTNARPISDSFLLIMIPFVGGSLMDGSYALSFTQYVLPSKRPKRILSAAARPSRDDSRVDAAMHALLLFEDEKGNPITSRIYTDMSRSRLGGILPRVWELPSIEVETDAAIIYFYNAMMPHIYHYISITDKRTGMTEYKTQSSGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR9</accession>
    <name>D4DFR9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019919.1">
        <property type="nucleotide sequence ID" value="XM_003019873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR9"/>
    <dbReference type="GeneID" id="9584670"/>
    <dbReference type="KEGG" id="tve:TRV_06020"/>
    <dbReference type="HOGENOM" id="CLU_002741_2_0_1"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109701" checksum="D6C3A3D9CB3D0171" modified="2010-05-18" version="1">MTKVVSPHLLDDVRSADSTAGRIAALRTLKNDIIGHNQKKQAWTELGVLPLLSDVLFSRRGVARKADFHSHSPKQHTTEEDEMCFQAITIIGSLALGGPAYTAPILAGETIPSLLSVLSSPSCPRSLALAVLRTLNTIADQLALVYQNVDNQTQPMGALLFTRKYISTFRGILQQPGDSPGAQPCIELVADLISKTCSGEQQKSLLAECGILDVLGLRLAAFVVAGGFVLPGAENSCTNSGALGHIPDPAPADAKLTPILRAIAVIIEQSAARAEHLLTCPALVTVFPRSFYDLYLGEAKKGPWRSPYPSGYGFTKRNVLNPIDSLLPSVQPMQNNGSSNFPPLGSQPQYDKRGQFFGPQPPCTDSPAPEEPESVLVSWLLYVARADRGYVRLMAARILATLFRHHLLKKSRVPMLGFLLVPLLVRMLDSAHHSEDYSTFNSYALRVKEEAPAVLASLVMDSRELQKFAVDSGAIKKLTQMLKESFAPTSEAGTPMWSTTKRPATVLVQSTDSDTSLGPPGFTRQALSKIKYREAILKALAALSLVNDDYRKAICDTGVVQHIIDSMKPWNPETTVLGNKTCITELEGNTTPVILAACAAARSLTRSVSVLRTSLIDAGIAAPICDLVKSSNIEIQIAATSVMCNLALDFSPMKEALLEANMVPLLCENSHSPNANLRIESLWSLKHISYNVPNKMKKDILEALGIEWIKQVLSHDPNDPVNARRRQDDIASELPSSLIEMGTSNSFGEQVDILNPVIPSGLEPESPMMDFDGHIPDSSIASKPAVDTHSAENVRKRRLALNGDLDQTKKLRQDDTLAQEELFDLLRNIMCGPGAPDMIDYLLQKFGQTDFLDILASKLRPRPLPTANASIASFKDKLTTSQQKSILHPTEIIRAVTYVLIHIAAGVSRHRHLLVFHQDLLKLTMALLSHSNWQIRANCVWIVINLTLDDDKTDKTSRVERAMRLKSLGVMERLSSLEIDSESDVRERTKTALDWMKALLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ8</accession>
    <name>D4DFZ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019812.1">
        <property type="nucleotide sequence ID" value="XM_003019766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFZ8"/>
    <dbReference type="GeneID" id="9584563"/>
    <dbReference type="KEGG" id="tve:TRV_06100"/>
    <dbReference type="HOGENOM" id="CLU_372521_0_0_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="762" mass="83431" checksum="D9D03E9AEB2283BD" modified="2010-05-18" version="1">MNPHRLGQSSGNREPEGANTIPFPPFPYDMPEEVETFNSRPTQLQGPPPQYTGSYGRLAGYPGEAAKYASVIRDKLGADPLVTHTHTHHYSYMENTFRPQPPITYDAASRLALANPATNNSYVHSQPTAQAESFAAGAATSPEGFSHYPQQERGRPFYRGAPSFRLRSQGRERSQPAYQHSSRISRELRETGHLTSTRPSSLATLAALTTKPNLTTTQGSASFGVENTTEMEYYYHNHGIPGTRSNSRVVTAINPALTAHPLQNMAAMETGGNHGHAVELPAHFNPHLHSPHRARHIGQHSFSVDPGSSHYTPPAFAPPSMPRSIPQVNFARHTKNATLSAPATSVATPTSKTRPTTPTGPFIPGPDNISPSKQEEKLHAQKTMMERLGDTSIANALDIDFSRLTINQADHYLDLIGAPSRPKPESAPVRNVTAGEGELVAPKLAPQSLAPEKSMTASLSPHDHQLPQRSLPSPSSQNYSNDLERGTALAARYNIRGLAITRLAMFRQEREAAMAQEREASPQVAAGSRAPSPTSTKVNLSATPCPSEGRNNTATQQPGIRRSFPPPGLTRPRFTNYAGDPVGIYRPVPWTVDTPEEAERKAKKAETATTSEAGKQPPVLPPANTLQQSPIGSKRRSILLAKERNSRVSETLKWYRADYRWNEGLRERLDTIIKENLQTRDNGQEPVAIPKELYESAEQNTVLLAQAIVNLQSYLEGNPKEQSRNFAQYGPAPDECCEPSKDGNFSLFDIQPGPFRGSETRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGK9</accession>
    <name>D4DGK9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019684.1">
        <property type="nucleotide sequence ID" value="XM_003019638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583572"/>
    <dbReference type="KEGG" id="tve:TRV_06313"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="499"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2154" mass="239195" checksum="3B2464B5689F5EBC" modified="2010-05-18" version="1">MSQLHISQLWKFNSGVSEEPWMECFHAVVERHARENPLSQAIDAWDGRFTYAELNNLSILLAKYLQSQGVGPGSVVPISFERSAWAIVAMLSVSKAGGAFVSIPPYLPSGRREAMVQMISPSILLTTSDFCHLWATGPKCIPIEGSRINCLPTSELPLITRSKPEDTFYIIFTSGSTGAPKGCMVSHSSFLNGALRKAPEWKFGPKRRVLQMLSHTFDMSLLEICTSLGSGACVCVPRTEDIEDSLANAINKYNVSLAVMTPSLARQLEPEAVPKLQVLCLGGESFPKDLVTLWSERINLFQFYGPSECSINSSTRAITHKNTDPLNIGVPNNAACWVVSPEDYNKLVPIGATGGAFGLWCYCRPRLNGQRLELGEVEYHLTLEEGVGHAMAMVPRTGRCKDNLMGIISLKSSPPVDSNDEISTLQGALVDQSIQSIRKRLQNSLPRYMVPTIWACILRMPMSASGKIDRVRVRRWVEEMSESTFREITGGIQQPGDRNPLSKMEQFVQNIWSSVLDLSPQDVGRHQSFIQLGGNSILAQEVVAKCRKEGIGLTMTDILTCNGIAGAASLTTALGNNESQTRLLSSTSTPVWRKLREKYDLSRLGVSHIEDIEDVYPCTPMQIGMFLGQIRKPGSYHLRFFYKPIVKGGKLPELGRIESAWHQVVSHHTSLRTVFVDDLGVGAEYHSVVLRNAPVDVCIDEVPEKFSPSEAMETFTKSIKRFAKRSTFHRISLCVCGDKVTYLMIEVSHALVDGAAMENLMRDFATAFDDGQLLYQPQPYREFVKYVASQNNEASARYWTTYLKDCPPCMIPVSKQMMFDDLPTRFLRKDFVYEKSSDFLAKCKERQITVASAVRVAWALVLRAYIGSSDVCFTYVAAGRDVPVKDVNKMVGLCLSIQPCRAQLCTGTTFVSLAERMQQEYIESMPYQHYPLTELKARLYPKGSEAMFNTAVSMEWTARTDPFYNTSIAFEEIREQDDPTEYDIVANVEIVDNIMKLGFLYWPSFSDIDVIHIANASKKALDCLLDSADKSVEAISLDGEHVFHAMKSSDQESLHHTETCVFDAIERQAMAQLNTQAVVSWDGEYSYGQLTKYYTTYAKYLVEQGVNNGDIIVVCLDKSCWSVITILAILKAGAVFVATNPLHSQQRLESIVNHCQAKLIIVEPRYSSLFETVDTPTVVVNKETVERALLSTTLPTIRDSDIATIVYTSGTTGLPKGIIIDHGSLCTSVLQGHGKRYGFDEETRALQFAAFTFDACLQEIITVLSHGGCVCVPSEDARLSDLGGCITQMRVNLALLTPTVARLIRSQDVPCLKRMILCGEPMSRQDLEAWAGTVTLYNGYGPAEATICVSISGPLDVSNDPANIGYAVDGTRLWITEAADYNRLAPAGCIGELVIESRQVSRGYLHDVEKTNAMFINPAWLPGCRVYKTGDLAKRNPDGSLTYCGRKDTQVKLRGQRVELGEVEYHVCECWTNASGVVAEVIYPTGEDKATLAAFVCTSDAQNNALGDLDAPEEPKTGLSPVWVSKEFIEQLEDRLPCYMVPSIFFTIPSVPLTPNKKTDRQHLRDIGSNFTSEQLARVSDHQNNSKRMPLEARERKLQQLWSFVLNIDRSQISLDDSFFRLGGDSVSAMRLVTTARKSGINLTVADVFRHPHIDEQARIASSSSNNILKTLIGKPFAHIQRKDLERVVSLVGLGPYANIASDIEDILPATDLQSFYASRIAEASRDALNYFYLRFDNTPDVTRLRHACQSIVDQFPILRTIFIPTQGRTYQVVIRRLQVPLEIHNSVKNLSKASDLFCLQDLENKIISGSLFLSFTLIRHAISGSQLIIRMSHAQYDGMSWPLILRCFQESYAGVPRSPTQSFSGFISYTIGKVSESRKYWTNLLQGSHVTQVSAKFTMETPLQRVEKTHVEKTVELPIPPKGITVASLVSSAWSLVLRQITGKRDVVYGFVVAGRNIGMPQIQEVVGPCMNTVPVRICFNSMRTTIDLQRHTMNQYFAMGDADSLGFQDIVENCTQWPSGTKLDTLLQYHDIDETPVVTLSGGPDSEPCSAQLDWFRKPYAAPTNIEVSARPNGKTLGITVSSDGSLLSTESATAILTMFERSIRILSNGRAIPLDSINLLAVAARRNQPKIPDLCPPAYLTFQLLSLMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGM7</accession>
    <name>D4DGM7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019614.1">
        <property type="nucleotide sequence ID" value="XM_003019568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGM7"/>
    <dbReference type="GeneID" id="9580143"/>
    <dbReference type="KEGG" id="tve:TRV_06332"/>
    <dbReference type="HOGENOM" id="CLU_883365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="35843" checksum="8AB6CDAB01CCCF31" modified="2010-05-18" version="1">MLLFSYIYIYRREKARPAEDDVIIGSGRHQKKRNQSKPQEQERSEREEEEEKKRRSVEEEEEEQGSGGRRVEGSGTGERDKGAVRTGRMALSGQRRRGQAGQTERDKREIRDRDTRQRASERRDDAVTDNVVQSLGRESLQSSEEADVGSKNAQGMKTRARRERDEKNVGDRREEEEKKKQREIEFYPWLQPASQPAEGLDYICTQRSYLTARGEDIVIRLSSKTSSPRRDVFSSSTPFIIFISFRSLFVSVSVGLVRPLADVKRARDSDGEVDRRGPTGDGQRVLFKTDDSRPGGGSSDVVVVVVVVVDSWLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGQ6</accession>
    <name>D4DGQ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019643.1">
        <property type="nucleotide sequence ID" value="XM_003019597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGQ6"/>
    <dbReference type="GeneID" id="9583543"/>
    <dbReference type="KEGG" id="tve:TRV_06361"/>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="26119" checksum="30CEDE3E3B4C3701" modified="2010-05-18" version="1">MAQTPGILSAILNFFPLKRRNLVIGIKAQQSINPTAWLTSRLPDLRLKTVRTHAARFFDKEGNLIVELIRQADIPIILQFINELAEYEKAQHEVQATLSSLRETLSFPDSPKRGSVYTFLITPPATEADSSPKPVGMALFFYNYSTWRSAPGVYLEDLYVQPAYRGKGYGFKLLQTLAQEVIRIGGKRLEWSVLKWNEPSIKFYKSIGAAPKDEWLGMCVSGDALNNLAGQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH23</accession>
    <name>D4DH23_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000368">
        <property type="protein sequence ID" value="EFE38854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019499.1">
        <property type="nucleotide sequence ID" value="XM_003019453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH23"/>
    <dbReference type="GeneID" id="9578191"/>
    <dbReference type="KEGG" id="tve:TRV_06478"/>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="502" mass="56544" checksum="8E48AB2B7978ED11" modified="2010-05-18" version="1">MLDKRLNDKGKNWRHVLKSLKVVDYCLHEGSEQVVTWATKNLYIIKTLREFQYIDEDGRDVGQNVRVAAKELTSLLLDEDRLRSERSDRKLWKSRFAGMDDGMRGIEGGDMSHRQRRRERPQRPADDEDAEYRLAIEASKYEAEEDRKRREKNASRDLEDDELAKAIKLSKEEEELRRRELEESNAASLFDDSTPQPAQPQATGYNQGYQQQGAVDWFGNPVDPQQPMTTGFLNNQYAQPTGFQPQQTGFNNSFPNGFQQQPTGFDQQFLQPQSTLQPQQTAFTSNPYGNDLFGQQQQPQMQPQQQQDGFLQPGSHNPWAMNQQKPAEALKPAPTGSNNPFASSFTRAQAQQSQIQKTGPPSLNALAEQKTATQFNNPIMNYQAPQQQQQQQQQLQPMNNQQQINQNPQHARLNALLATGDGQDTFGNVGDLRIPAQHTAPGVFVNSAGSGLNQIQASRTGNNPFLTQNFTGAPQQQSNPGFGSQQGFARPNQQGSNNLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH26</accession>
    <name>D4DH26_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000368">
        <property type="protein sequence ID" value="EFE38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019502.1">
        <property type="nucleotide sequence ID" value="XM_003019456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH26"/>
    <dbReference type="GeneID" id="9578195"/>
    <dbReference type="KEGG" id="tve:TRV_06481"/>
    <dbReference type="HOGENOM" id="CLU_008401_0_0_1"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="277"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="654"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="901" mass="97521" checksum="A8DE94CB0038ABAA" modified="2010-05-18" version="1">MADEEDYSSLPLPERFAHKVWKVRKEGYEAAKKQFEISPDEDAPVFRPFLQDPTIWKGVVADTNVAAQQEGLAAYCSFLQYSGAQACNRTRSVTAAPIIEKGLPQTRPAAKASALEALLLFIELDKPEPVIEELVAALSHKTPKVVAAALSALTSIYHNYGIKIVETKPVLKALAKVFSHADKNVRAEAQNLTVELYRWLKEALKATFWNDLKPVQQQDLEKQFEKVKQDPPPKQERFTRTQQAVMAEASANPGAEDGMGEAEGDNLEDDGEVDVFDLVEAVDIIAAAPKDLHQNLASSKWKDRKEALDDLYKVVNVPKIKEGNFDELCGDLGKCMKDANVLVVTVAANCICAIATGLRKGFAKYRSVVMPPMMERLKEKKATVSTALGQGLDAVFLSTSLTDCLEDILGFLKHKNPQVKQETFKFLVRCLRTTRDVPSKGEVKSIAEAGTKLLTDSSEVTRSGGAEILGTLMKIMGERAMNVYLDGLDDIRKTKIREFFETAEVKAKDRPKPIIGPPKTTATPAKKPMGKKPLGVKKPAPASAAAAAPAAAPSEPPASPAPAKKAAPKIGAPRGLATPGSGLKLKSKLAGPGGAASPQRRVVSPPMEDPAALPPPPPKFGIGGGGRGLASRPIGKPSAPVQEQPIAQIATGLSAIERAELEELRAENARLSKMTEELRAERSRLSSEVHELQNQNAQLIEDHTRDVLSIKAKETQLVRARGDAETAEQSVQKQQREIERLKRELSRAMRAGATSPPMTLPDMSLNMGISDNGGIYQDDMHRINGTPSRASLHMGSRFESARPRSFVSSSPSEEKENTGMVSPALSTGFSGRRKFSPPAGSAYSSGRGSPARTSRTPTGDAPVSIEPSENWKRAAEVTSQLKARIEQMKARQGLSRPPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHF4</accession>
    <name>D4DHF4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019329.1">
        <property type="nucleotide sequence ID" value="XM_003019283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHF4"/>
    <dbReference type="GeneID" id="9577686"/>
    <dbReference type="KEGG" id="tve:TRV_06610"/>
    <dbReference type="HOGENOM" id="CLU_012622_1_0_1"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="850" mass="94993" checksum="CA8FC71C472A5DBE" modified="2010-05-18" version="1">MSFFGFDTKLPEDRPAASAQRGIFDAPDPFAEVARATADRAGYDDDDVIDFEDTYDGLGDQLEEANDDFNDDTFGDAAGGENKPVGKDFDFFGNTAQMTNVLGEEQVLYNLQHGSSKATAKPSLPSLPKRTGYEKYQDPGYIPEIQAKSSVWGTTATQKPKTVAAETVPKEQPASEPPKKMLSLEEVEAQMRMQAMRQVPQQPQSQPPPPQQQFTAPMPPPGVPPMQFPSQPLLHHPDALGQLPPEELLSHQQYPPNNMPPPLGFPQQPHLQQQPQQPNFPLHLLQQSQQQQQHQPQRHQQQQVQQQQHRQPHQTGRHWAGPARHQGKPQGPYTLDHPLMGQGGVPAALNPKIMELPEEQRNAILLEDAKRAKRNHKIFLLSKGNGLMTPQDKNFITRIQLQQLVTATGNTGDANPESLLTEDFYYQVYSQIRGAPRQHPRQPLGHFAQTYLSQTGGRSGGNMNRRSHFSGDNHMQRMQQQVQRAVEAAKLKPKNKQLIIEGSLGKISFSNAKTPKPLLNIKRPESSDGQRPSTAKKTQLSSSDRKSILQNIETVYITLMNMENLVRLMPPIPNPEVEDEEAVERYTEWQRKMQSLKEVLWDSTKVLEPIDSVSATIHPFIAFLSYPKGKKAIPRIFHQIDQEQRITMLTMIIYHLDTLDVVSRAQLQPGETQPPGPVREEIELFNQAVMPSLLGYVSDAPIHIVIGLLGLVIDKTQIHAIARTKIGLGILTMLLSQAELVKEAGGVPEPELAQWTKVYNRLFDSMEPALAYLFPGTINSGDDMYVWQFLAAMGIGANPEQQQRLVIAVKDRVLETVAQSKTLPADMASQRLGNVNLFMRAIGLDVELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHT3</accession>
    <name>D4DHT3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000387">
        <property type="protein sequence ID" value="EFE38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019228.1">
        <property type="nucleotide sequence ID" value="XM_003019182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHT3"/>
    <dbReference type="GeneID" id="9577225"/>
    <dbReference type="KEGG" id="tve:TRV_06740"/>
    <dbReference type="HOGENOM" id="CLU_066912_0_0_1"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="38760" checksum="DBF57F54744C7E56" modified="2010-05-18" version="1">MSSTSSKRSRSEEPHEKYKKARYTYQQNAHGSKHHKRNTRNNAAGSSGPSVNDLKSKIRATKRLLEHSKTLPADVRIEKERALKGYQRDLEKVEENRARNAMISKYHFARFLAFANYPLIIERKTATQNLKKLRRMKEKLENSEENDDNEKNSTTKSRADQLAELEKQIYSTEVDINYAKYSPLTEKYISLFPSDKSKDKEGRKKNKKDGDDGEEQEGEGEDGEEENQEKSALGQKLAPIRYASSERPPLWYAVEQSMKDGTLELLREGKLGITVTGERKGANGGIKEGDMASRQSKAKGSYSTMSTKEIQGGVSLRGENQRMDKARDDEDDESDGGFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV3</accession>
    <name>D4DHV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019211.1">
        <property type="nucleotide sequence ID" value="XM_003019165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV3"/>
    <dbReference type="GeneID" id="9577208"/>
    <dbReference type="KEGG" id="tve:TRV_06760"/>
    <dbReference type="HOGENOM" id="CLU_1078450_0_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27949" checksum="7746DC70ACFA8E85" modified="2010-05-18" version="1">MGEEHQLTVLLGVLLHSLRFSCVRRAFLRINGSFIAPVDPADAGYQWSTNSFPRKMATSTSLAIGSFLQIPTYPDIVLLVVRLLLFINIAMTLYPIYRAPDQVSDIPLTPSQRALLGLDPNSTSPATQGTEYITPPRYRISSSSRRRSSGSWGNSPFSYSGAEDSPTRSHPDSPPFTPSGSPLFQKGIRSGGRDSGRRNSFGSPSPLGRSSIGARDGSSLRAPSTPTPFGKGTSPVMTQKWLFERSRMSSSGSSVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI86</accession>
    <name>D4DI86_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019069.1">
        <property type="nucleotide sequence ID" value="XM_003019023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI86"/>
    <dbReference type="GeneID" id="9582554"/>
    <dbReference type="KEGG" id="tve:TRV_06894"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055542" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="502" mass="54534" checksum="EE65D1A7AEAFF0D3" modified="2010-05-18" version="1">MQGLLKGIIIALAAWANSSAARSIQQQQPSTSDVTPVNICPRAMDNWIDDIKTELVPKLSPEAKVYLPGSGDFDTATARWSALGAPAVNAAISAAVAQDVVETVKFANRKGVKFLAYNSAHGALTSLGKVDSGIEIFMKQLNSVEIAQDGKSVKVGGGINSKYLVDTLWDAKKQAALGGGHGWLQGHHGLIADQFLSMDVVLADGTLKTIDSNSDLFWAMNGAGHNFGIVTSVTLKIYDIEHTDWAIETLTFSGDKVVPIYTAANNLLKNQPEGVIHWSYWLNNPSADANNPVIIVYLIQEGVKQVDPAITGPFHDIGALSVQPDSGTYKDLGRWTGIALDSPPCQKTGASNPRFPIYLESFNVPAMQQAYKLYASQANVSGPFHNSISMFEGYSTQGVKAVDPKSAAYAFRSDNFLAAPLISYESTGSDLDQKAIDLGQQLRQILLKGSGRSELHTYVNYAFGTETPQQWYGYEQWRQDKLKALKQKYDPEGKFSFYAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI97</accession>
    <name>D4DI97_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019080.1">
        <property type="nucleotide sequence ID" value="XM_003019034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI97"/>
    <dbReference type="GeneID" id="9582566"/>
    <dbReference type="KEGG" id="tve:TRV_06905"/>
    <dbReference type="HOGENOM" id="CLU_009292_0_0_1"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000560">
        <property type="entry name" value="Putative PHD finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="270"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="833" mass="91184" checksum="C292C18C0F51C389" modified="2010-05-18" version="1">MADEPRRSGRATKGQHKNLDIDPPQNKRKSKGQGKGQKQSSNEPTPPVLNEEDEIIRCICGEYEEEEDVERDMICCDKCAAWQHNDCMGLIFPKGEEPAEYFCERCKPENHRELLDKISRGEKPWEEAAAKRAQEAEERKSRKKKGGKRGKKARQSDVKPEHSDTPTMAKSDKQSPPMQHNIEVAVPLHHEDVGAHKRKHEEREESITQESGSRQKLQKLSTNLPASSSPVQSGMQSARQSATSPMTPSQGPNLKSRSGSTAGTDHLIVARRSAATALSKLVTEIAGTAVAAGTFTIPSDSTKEAVGERLGTEIEDCMYRNLCGSAGEPNDAYKNQLRTILFNVRKNPSLRDSLLVGRTTPDAISTMSTQNMASQELREKDEEIKREAERQHTIIQEQGPRIRRTHKGEELVESDPQTIGTESVFSTAPARRDTATESELPSAKSPRHTSPTAAHGQPHADRTTRETSDTNRRNSSNFNIENVWSSVHSPGASHSEQQFGPASSFNEPSHPMNKVQEDAEIDNLLRDEADSPPYSPKDIQDDGDIWHGSVSMSSVAEFRTAGRHVGGADLSAKIPWSQLVPPRITVDGRIDVQLASNYLCGLRYSHTTDISVVALEQPHSADDAVQFNRLFNYFMDRKRYGVVGKHPLPAVKDAYLVPVEAGHSKKPDFIELLENNQVQDPTPTRLLLFVLVVKTNFNQSTPSHTTPQAPSRSAASPLQADNEYNPVDPAGLGHAQGNTPAQGPNPQQGQFNNGSTNAPSPGQALTGQQAAIHVLGPLAAAPAIQELLQRAPNASVEQLNVIAGILRQNPQAANNLQLLMGAILQTTNGTQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIP1</accession>
    <name>D4DIP1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018919.1">
        <property type="nucleotide sequence ID" value="XM_003018873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIP1"/>
    <dbReference type="GeneID" id="9582078"/>
    <dbReference type="KEGG" id="tve:TRV_07051"/>
    <dbReference type="HOGENOM" id="CLU_629986_0_0_1"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="435" mass="49880" checksum="A0CCA4639B4003B9" modified="2010-05-18" version="1">MAEAETEGAGVKRVGSSMESLRRKKFKLSELPISTAQRTTIENLLYSFKKKGGFDAVRKEVWAKFNNSDAKNSFTASLIEMAESEIERDPSLLSRERGKAATLISGAVDRSDLHSGIEETVDAIISNHIDEILASLRKIRAQDIGQEAANAEIAKGLTTDAEYEKQVQAKRDERERIRQKELEIERKAEEERKKAEAEEKRRQRELRKQREEEDRKRREEREQKRRAEREKQREEDRLREERREREREERYERRRREEKERYRERERERERDYDRDKSRRSDLDRGRDGSGTPRDTSRAHKTPAPPVDEKALEDAALELLLKEGKELAAKSRQKPEFDFEQAEALENGQALQPANTTTRFADVAAAGPEAELEQGDPQGTMTNIEMPTQIGESQKGGLVILMYTGLENETDETETTTLFALGLGDGAGLGAGAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI4</accession>
    <name>D4DJI4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018662.1">
        <property type="nucleotide sequence ID" value="XM_003018616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI4"/>
    <dbReference type="GeneID" id="9580815"/>
    <dbReference type="KEGG" id="tve:TRV_07352"/>
    <dbReference type="HOGENOM" id="CLU_034114_0_0_1"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="39995" checksum="98E5499FDC95F07B" modified="2010-05-18" version="1">MAITILPPTFDDFRNTARDVQDSDEDMDMGDENRPAKRARLSGITDTIVTPGEIITDDPQWMRGHGTFTPAVPATTNIIATVAGTVLKTNKLLSVYPLRARYTPEIGDLVVGRIVEVQSKRWKVDVSAPLLAQLPLSAINLPGGILRKRTAADELQIRSFFNEGDLVVAEVQTVHGDGAASLHTRSLKYGKLRNGLFLAVSGMGGGSGTARGTGVVRSRRQVWTIETAYGGPIDVILGVNGYIWISKHVRDPSEEDSSGFKSKVSFTRLEDMVSTSMYSSQNDNIPLATRKEFTRIAGCIRVLVEGGVKVDQETVMKAYEASLALDDEEEDSDMEGDDGQGSTRKDGRYYLGGEKASRLIATVLSRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJS4</accession>
    <name>D4DJS4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000444">
        <property type="protein sequence ID" value="EFE37896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018541.1">
        <property type="nucleotide sequence ID" value="XM_003018495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJS4"/>
    <dbReference type="GeneID" id="9584470"/>
    <dbReference type="KEGG" id="tve:TRV_07442"/>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="59"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="473" mass="52784" checksum="F4A3975DC3029601" modified="2010-05-18" version="1">MVNKVIPLSLYAQLGDSDINLPGSFGTYPIAVLNKFRELQDKFEASPDRFLRFELAFYLLESRKALGSLLNTPVDSTVFVKNATTGVNTVLRNLVYQPGDVIVYFSTVYGAVEKLIASLAETTPVRARKVKYEFPISHDKLVQRFMDTVTKARSEGLNVKIAVFDTIVSSPGIRLPFEKLTEVCRKEGILSCIDGAHGVGQIPLDLGKLDPDFFVSNCHKWLFVPRGCAVFYVPQRNQHLIRTTIPTSHGFVPVPGIMKTGSELGEEDEPFAKPIDAFFTQSDFELQFEFIGTNDDLPYLCVPDAIKYRQEVCGGEEKIMQYCQTLAFEAGNRVAGIWGTDVLSEFCSSGGDLDVTKEKRSEFRKCAFANVRLPITLVDDQNVPQGKLVKAEWPVVRMADAVPTCRAMEQRLVLKHSTMSPCYVHAGSIWTRLSAQVYLEVSDFEWLASAFKKIFEELAIQGGMASLDINPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK00</accession>
    <name>D4DK00_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000447">
        <property type="protein sequence ID" value="EFE37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018467.1">
        <property type="nucleotide sequence ID" value="XM_003018421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584394"/>
    <dbReference type="KEGG" id="tve:TRV_07520"/>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="541"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="738"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="141591" checksum="DF6D5B40D2C4A3E9" modified="2010-05-18" version="1">MEDDVVIKLLSEDPSNYKDAPLEGIRRLLSKFQGEEIPRGVPLDTSKIESIRMGTTVATNALLERKGERMALVVTQGFRDCLKIGNQSRPKIFDLAIRRPDDLFEEVVEIEERVTLEDYAEDPTRHATPTVARTEEAKDADIVRGLSSEAVRILQRPSEGKVRDQLQALYDKGFRSIAVCLMHGYTFPDHESLVGKIASDIGFTHVSLSHQLMPMIKLVPRATSACADAYLTPTIKRYISGFQSGFKGVLGAGGVKDPSQPKSARCEFMQSDGGLVDVNGFTGLRAILSGPAGGVVGYALTSYDPKTKIPVIGFDMGGTSTDVSRYGGRYEHVFETTTAGVTIQSPQLDINTVAAGGGSRLFYRNGLFVVGPESAGAHPGPACYRKGGPLTVTDANLFLGRLLPEFFPKIFGKNEDEGLDEKASAKLFEELAEKVNAEMAESGKRGKMTADEVAYGFIKVANEAMTRPIRSLTEAKGHDTSKHRLATFGGAGGQHAVAIAENLGIKQILVHRYSSVLSAYGMALADVVDESQVPESMSWSESSEVKASIEKRMQELRKGAVARLNDQGFKEEAIVFEEYLNMRYRGTESALMIIKPQEGGAFGKSFIEQHEKEFGFTLPDRDIIIDDIRLRAIGKSFDSFPKTVDEQLRDAKPVPVSKSKAHATQKVYFEGGRVDTPIYKIGSLETNDRIDGPAILGDGTQTILVTPTSSALIIDTHVVIDVDVNKKESTKASADEVDPILLSIFGHRFMAIAEQMGRALQKTSVSTNVKERLDYSCALFDSDGGLVANAPHLPVHLGSMSTCVRTQAGMWKGKLKPGDVIVTNHPEFGGTHLPDITVITPAFSGNEIVFYVASRAHHADIGGILPGSMPPHSKELYQEGAAIKSEKLVSEGKFNEERMVELLYREPAKYPGCSGTRCLADNLNDLKAQVAANQKGISLISTLIEEYGGSTVQLYMKSIQKNAELSVRNLLKQVSERFKGADLTAIEHMDDGSPIHLKISIDAEKGEAVFDFEGTGPEVYANTNAPEAVTYSAIIYCLRCLISEDIPLNQGCLKPINVKIPKGSFLSPSSKAAVVGGNVMTSQRVTDVILKCFQACAASQGDTNNLTFGFGGNLSGEEETKGFGYYETIAGGSGAGPDWEGTSGVHTHMTNTRITDAEVFERRYPVLLREFSLRAGSGGAGQNRGGDGVIRDIEFRIPVQVSILSERRVYHPYGMHGGEDAACGQNIWVRKMPQPEGSKEPPIIKHVSLGAKNTANMEPGDRIIIKTPGGGGYGKPGNESVVRKEADPQLAWKGGSLASRVGTQETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK28</accession>
    <name>D4DK28_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018449.1">
        <property type="nucleotide sequence ID" value="XM_003018403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK28"/>
    <dbReference type="GeneID" id="9584379"/>
    <dbReference type="KEGG" id="tve:TRV_07549"/>
    <dbReference type="HOGENOM" id="CLU_014456_0_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="98"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="628" mass="69915" checksum="A13BF8A3DEEBE4A8" modified="2010-05-18" version="1">MWNDEDNNPYGALDRNEDPLGGSFHPAAMAPPAYQERPASPASSRSSTRDPPDFVTRTDTPDLDDDEDQNEYGGQQQPYQRKKGIYDSRIEQILYENPELPILITDAGKNSETGGSFIVYTIRTGDLEVRRRYSEFSSLRTALVNLHPTLIIPPIPEKHTMADYAAKPTKAKEDTAIIELRKRMLAVFLNRCRRMNEIREDGVWWRFLDPNASWGEVLNSHPAASVPKNNLKAPPLDPANPTPAHNWLPVPSSSAKLKPTASDIPASSAGAPSFMNRFPPTSKTLSEHELDPYFVNFEASTRELELLLQGSVEKVNRRTLTHLTALSSDLMELGARYNGFALSEQSPTVAAAIERVGQAADNSYIETEELSSTLGATFSEPMRESAQFAGVVRGVLRYRILKRIQQEMTRDELNKKSALLDSLERSEIEAQRIEEYLNKSSSGSSPKTRPGRSLSEASSGSNPEPAPESPPANAEDTASIDSDFPPTHGEPVHRPSASQGLPHRPVDSTPSGHRKSSSGNFVTNKIFGRISHAIHGFADVDPERTRRDQIGKTKESLTQLEQALKVSEQDVKDASSGVLRDLKRFQKEKEDDLRSYMVAYARCHLDWARKSLETWTEARDEVDKIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK45</accession>
    <name>D4DK45_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018412.1">
        <property type="nucleotide sequence ID" value="XM_003018366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK45"/>
    <dbReference type="GeneID" id="9584340"/>
    <dbReference type="KEGG" id="tve:TRV_07566"/>
    <dbReference type="HOGENOM" id="CLU_012131_1_0_1"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="230"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="79960" checksum="EC38248DCCBEB7CB" modified="2010-05-18" version="1">MPGRLTGGEKTAQTNIVVVGIGNPTDSHLDRRRRTGGATGAGKVATETETETVKATDPLPDTTMMRTIVTAAAAVTPTADHAVEFEVDLGVERVVEVIVAAEVSSELAQYYHVRGLEDVRVIRDKQTNLEISRQLAFIRFPSIDDSRKFLELNFPAVHLYGKAGGDGQGARVRIAYSREREDRNRARADGEWTCINSLTLVDIAVPPVEETVKVANYGDNDVSTDGTPSQFLLFRGLESSVTEEVLAKGVAKLCKQSKSAAASASSGSSGVGGAPAKKVAKVASTTGDSNLGARDGSIRRVLLVRDRRTNESWGYGFAEFATVEDAQCALTRYTSLDTFTISSKPVLASYIHAGVFVPVLNLNPGVHSSTTGTNSELERFTFSPLGNLAAKLAYWDEEAYASELKLATAAATSELSGKAGGMASASAQKTSAARAAHPGRDGEKEKKRKKVEATAGAAAGSATKKIAMASHLQFWSNRHAELHGIDRRSAETGDGDHFNDPGTAAARSQSQSQASTPHLQPVQQQHQQHQQPEQPEQPHLQGQQSYADLNRLCCYLCMREFKSEAHVRQHERLSQLHRENLQDETLKAKALAKLAKKRTLAADQTEYRDRAKERRKVFGSSKSRKREAEDDRQDEYEQGPGSNPVGSDTAASPPPALSKGAALLGKMGWSAGSGLGAEGTGMKQPVAADLYVQGVGLGAQGSKVGDAVQEAGRSTRGKYDEFLEKTREHARERYERMKDEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK92</accession>
    <name>D4DK92_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein receptor Pex19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018377.1">
        <property type="nucleotide sequence ID" value="XM_003018331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK92"/>
    <dbReference type="GeneID" id="9584299"/>
    <dbReference type="KEGG" id="tve:TRV_07613"/>
    <dbReference type="HOGENOM" id="CLU_043063_2_1_1"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="372" mass="40972" checksum="962987E02C3BC1DD" modified="2010-05-18" version="1">MADTNTPTPAEKEAIPVAEVQPPKPEEVKNELPTQAEEEESDWEELDDVLDDFSATKTTSQAAQDKIIPESQEKQEKSNSELSAADQDALLKQLEAGMAELMGALPTDASGQQTKEGDSSKEKTNDIPGMPQSPGNEDWNALTEELEKKGFTMTDVMKLMMGEELMTGGEGVTGMDGSTTTDKASGTAKQPSPSTKKGEDNFQETIQRTMERMQESGDKATAEVNESGNEDVLMQILKAMESSGLAGAGEGDDGNLDKLFMGIMEQLSNKEMLYEPLKELDDKFGPWLRENKEKIGKEDRERYELQASLVSDIVRKFEEKNFSDDKPEDRAYIWEKMQKMQAAGSPPDDLISAPFMDESKLQALGQEGCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKC7</accession>
    <name>D4DKC7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000464">
        <property type="protein sequence ID" value="EFE37698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018343.1">
        <property type="nucleotide sequence ID" value="XM_003018297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKC7"/>
    <dbReference type="GeneID" id="9580038"/>
    <dbReference type="KEGG" id="tve:TRV_07649"/>
    <dbReference type="HOGENOM" id="CLU_591800_0_0_1"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361:SF1">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="52815" checksum="27DE352659687B8F" modified="2010-05-18" version="1">MSSPAPTTPKAPRNGRRYQKRTPSSKSGAADPSRQPDKTNTTPAANRDSNVASDSGNRASDSATKAKNGRSAKKNRDNHHKNSPAPARTASLGHGHRHTSSQSSIKDSPLYAGPTFHASPAPSALPIPSFFSKSVPETDGRTSDELQDESPDTDPGDSTPTKANNAPQQTQQEAGTASPLDFLFKAARQARAANPVSELEDSGPFNGSTPPRNEVRPQQGERQISGGVFPLELEGSDTRMSPIGPSFATFFKDRMNALRATSPGKQGGLPGTTRENSTTDTNKLKSEALKNLLLNPPPQRAASASPRLTDPSNGPSNNGSNNNQNNFRMSGDYSMYQQPTRYASGPASPVPFAHSGKPLGTRNEFSGPESTIPQQYLASLCAQTHRSPAPSSGLRSMVSPTSPVTPPRQQSFSRYAQFGLSSAPPAHASYNGAAGGALTSPTPNRTMQPNSSTPPARNCPAPKLDSAETKRMEDDLRRMLNLNVGDGQQPENTGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN0</accession>
    <name>D4DKN0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000475">
        <property type="protein sequence ID" value="EFE37586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018231.1">
        <property type="nucleotide sequence ID" value="XM_003018185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKN0"/>
    <dbReference type="GeneID" id="9579609"/>
    <dbReference type="KEGG" id="tve:TRV_07752"/>
    <dbReference type="HOGENOM" id="CLU_057554_0_0_1"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="255" mass="28836" checksum="172FB32938EF2472" modified="2010-05-18" version="1">MKQSSVPVPSRADVMAACALRGPLANGIPYNNDVWVKYGTGVTEAEAILQQFVNENADHSIVYTPKVYDYFTGQRISNMPVTYIVMERVYGEALTSKEDDTVLENIAAAVRHIWELPLPPQASIGPLAGQVPYDRFFSDYGAGRTFQSTEELQAWINEKLKEEGWPDRVDLPSERCICHCDLSQFNILRGNPVIILDWGMSGVYPRIFDEFALFHQFNLRGSKFAKALHKKLFGDKLPRHLRPLTIVSRINTWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN2</accession>
    <name>D4DKN2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000475">
        <property type="protein sequence ID" value="EFE37588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018233.1">
        <property type="nucleotide sequence ID" value="XM_003018187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKN2"/>
    <dbReference type="GeneID" id="9579607"/>
    <dbReference type="KEGG" id="tve:TRV_07754"/>
    <dbReference type="HOGENOM" id="CLU_000134_46_5_1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="527"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="578" mass="63495" checksum="67665754FD0154AD" modified="2010-05-18" version="1">MADDLKAEGNKAFAAKDFATAVEKFSAAIELDPNNHVLYSNRSGAYASLKDFDKALEDANKTTELKADWPKGWGRKGAALHGQGDLLGAHDAYEEALKLDSNNAQAKAGLESVKRAIDAEAKADGVSGDPTAGLGNMFSDPNLIQKLASNPKTAPLLADSEFMAKLQNLAKNPNSIGNEMRDPRFLQVMGVLLGVDMSFGAPPEGDGATGGRSKEAEEDVNMPDARPAAQKAPEPEPEPEPEDEEAAAKKKAKAEADEEKKLGTENYKKRQFDAAIEHYSKAWEIYQDITYLTNLSAAQFEKGEYKDAIATCEKAIAEGREMLADFKIIAKAFGRIGSSYEKLGDLATAITNYQKSLTEHRTPEILAKLRAAEKAKIKAEKEAYLDPEEAEKARELGNKKFKEADWPGAVEAYTEMTKRAPDDHRGYSNRAAALIKLMAFPQAVQDCDEAIKRDPKFIRAYLRKAQALFAMKEYNKCLDVCTEAQEHDENGANQREIEQQQQKALEAQFSARAGETEAETAERIQRDPEIMAIVQDPVMQAILQQARNDPAALREHMKNATVRTKIQKLIAAGVIRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL43</accession>
    <name>D4DL43_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018081.1">
        <property type="nucleotide sequence ID" value="XM_003018035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL43"/>
    <dbReference type="GeneID" id="9579290"/>
    <dbReference type="KEGG" id="tve:TRV_07917"/>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="323" mass="35246" checksum="FFC2E958774BE961" modified="2010-05-18" version="1">MPSMTPSLGANTLLQPVVAFLGPLGSFSHQAAIEYFSSNNNTLKAEVSFNDAFSAVQSQEADYAIIPLENSSNGAVVQTLDLLADRENLYPDITVSGEYYLSVHHCLLMKKAQEGHGNSSEPNPEVSKFYSHPQVWGQCTKFLSAYSGVEKQDASSTSKAAEIVSKDNDPKSAAIGSELAGSINGLQVVKANIEDDPSNATRFLILQNLKSNRTQAIKPPQKTQSCSDPGSKCKSLITFMVDHTSPGALADALHVFKKYGLNLTSINSRPGGVKAWQYVFLVECQRVYGVHDDHVVEKVIDELRDITQTCRNLGSWEDQLMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL68</accession>
    <name>D4DL68_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018054.1">
        <property type="nucleotide sequence ID" value="XM_003018008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL68"/>
    <dbReference type="GeneID" id="9579178"/>
    <dbReference type="KEGG" id="tve:TRV_07942"/>
    <dbReference type="HOGENOM" id="CLU_122468_1_0_1"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="94" mass="10350" checksum="F7F28B622CDCD8A2" modified="2010-05-18" version="1">MITWDEKAHMKLLFAIISTSAPKVDHQAVANIMGNARIKTMVTDSNAASPATPKSKSARKKATKKRTAEEHSDEESGDAKKVKKEHVEESESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLA7</accession>
    <name>D4DLA7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000500">
        <property type="protein sequence ID" value="EFE37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018009.1">
        <property type="nucleotide sequence ID" value="XM_003017963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLA7"/>
    <dbReference type="GeneID" id="9579138"/>
    <dbReference type="KEGG" id="tve:TRV_07981"/>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="38435" checksum="53AE7A1C7DA7C72E" modified="2010-05-18" version="1">MLFSTSLVLGPEFSRDQELMAQITSHVLGIEEILGEFDRYPRILRPFVWGFSPICRAFRSNASILKEKLIPEIRRRVTLLRSGESAADDLTMLTVFLKQALKDGLLTQEQSPSDEKQFESLYMKSLFHIYEVWGPIAPLLIALLTRIMDSPEYVEDLREEVSKALASADGWDSDFLANTPKLESFTRETLRLNVAISVSVSRVLHAPLKLKSVDMELPKGSYIGLPTKFMHTDPELYRDPLTFDGYRFYDQASNTSTTRATTASETFLPFGYGVSLCPGRFIGVKAAQVAFSRFLLEYDVKYPIEGQKFPPMGLLENTWTYPEMDVMAKVRRRQSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX8</accession>
    <name>D4CYX8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_00015</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025812.1">
        <property type="nucleotide sequence ID" value="XM_003025766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYX8"/>
    <dbReference type="GeneID" id="9582055"/>
    <dbReference type="KEGG" id="tve:TRV_00015"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="399" mass="45461" checksum="2D873D762CD55494" modified="2010-05-18" version="1">MLNKLQGQPESYDKKAQYRFGKTLGAGTYGIVREADSPNGKVAVKIILKKNVKGNEQMVYDELDMLQRLHHPNIVRFHDWFESKDKYYIVTQLATGGELFDRICDYGRFTEKDASQTIRQVLDAVNYLHERNVVHRDLKPENLLYLTTAQESPLVLADFGIAKMLDSDTEVLTSMAGSFGYAAPEVMLKQGHGKAVDMWSMGVITYTLLCGYSPFRSESLNDLIEECRSGRIVFHERYWKDVSKDAKDFILTLLQPDPTLRSTSEQALQHRWLKGETATDHNILPELKTYIARNRLKRGIEIIKLANRIEALKMQDEGDDIPGTTLDEAEEKKAEDKPAADVKPSEGAAPANKGRLSRLARGAIFREVVLAKVREMKQQEQQQQVEKEALEKIEKDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ08</accession>
    <name>D4CZ08_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025783.1">
        <property type="nucleotide sequence ID" value="XM_003025737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ08"/>
    <dbReference type="GeneID" id="9582026"/>
    <dbReference type="KEGG" id="tve:TRV_00045"/>
    <dbReference type="HOGENOM" id="CLU_359683_0_0_1"/>
    <dbReference type="OrthoDB" id="5226996at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="854" mass="93757" checksum="A6E4618F95AAAE53" modified="2010-05-18" version="1">MSRRAKTGDVSDYLFCLSGSRYQNPWLPQNQTARLDVDRQLEDTLQQSAAQAAAADASLLEDGHGSPYYDRRYGSSSSRGRAVVTGPSKRKTYPYPYPETAAGRDGALSASTPSHRRRESSRDRYSVDVAGSYHSSSPQKRVVTGELPEQPTLRSRRGQDVTELRDRQERQSRFLEGSMNDKVSTRPPSVFIGEEQEYLLSTYMDEHNGGKGVNGWQPTAGGRASTAPLLQGKKGYLSSTKTNNTDATDAKSSGVFRFGKAIVSAINPMGVWGNVSEIWKGHDSSSKGSGSREMPVDTPHAARIEKAYQEYKASAAYRSTTPSTAPLHRYGYSGDDTGSPAKLLPVQTPQPQPSHHPSALIQSSISKELPPTPLEWQGLPVSTVSKRSSFQTIKGSRSFLNLSHSLRKEQSHKDLARENKLRKKVSNLEEKLLRYKRELSTFTHEEDKKVDELEGDAHAGLAVQVNNRVTHHLYPHTTAGPSVPSVPSPSPSPAPPSHDVRYVRMRPKKFVPGALPSLPSERLLDDGEPPTIREVSRQEASPEKPIYTRRSEPRLRRAVPRIREEDVTRTPAATTTKLTKEGASTPPSRKRKSPSPDHASVRRRRISATYSKNIRSNNNSNNANDSNDGASPPPSPQPNRRILTEKLTGPRPYPVNARTETEGRRNQPSRRAKEIKPVYYPNYDLTGRSVPVPERSESRPKHDQTPAPAPAKTPIPKSTPALPPQHGGPYASVEVAIPISVAPPIPSSTKPPPTPTSRQKSNQKQTADATANTASIPPPRPESVPATKDIISRSGSPRKHHNIPPRRKAAEKPISITPGKGGDENIPPVPPLPVEHGGSPLIEDGEFEWPEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ17</accession>
    <name>D4CZ17_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025792.1">
        <property type="nucleotide sequence ID" value="XM_003025746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ17"/>
    <dbReference type="GeneID" id="9582035"/>
    <dbReference type="KEGG" id="tve:TRV_00054"/>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="441" mass="48224" checksum="3E6242F67DB69455" modified="2010-05-18" version="1">MLSTREWAPLMSFIDGWLTLVGNWTVTLSINFSGGQLILSAISLWKEDFVPNQWQTILMFWAVMLVCALVNIFGSRYLDLINKICIFWTASSVLIIMVTLLSLADHRRSGKFVFTHYDATASGWPTGWAFFVGLLQPAYTLTGYGMVAAMCEETQNPHREVPKAIVLSVVAAGITGLVYLITLLFVLPEVKMLLSVANGQPIGLLFKTVTGSAAGGFGMLFLIMGIQIFAGIGALTAASRCTYAFARDGAIPGSRVWKQVSSRFGVPLWGIILSTLVDCLLGLIYFGSAAAFNSFTGVATICLSTSYGLPILISLVRRRKMFENAPFSLGKFGFLINMTTICWICFSTFLFCLPVSLPVTPSSMNYASVVFAGFATISVVWYFVRARKAFTGPPMSMDDARKDEAGVFSGKMAPHMEDGVTPLDLSKPAEVHVEHQAKFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ71</accession>
    <name>D4CZ71_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025694.1">
        <property type="nucleotide sequence ID" value="XM_003025648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ71"/>
    <dbReference type="GeneID" id="9581935"/>
    <dbReference type="KEGG" id="tve:TRV_00108"/>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50385" checksum="5F2333F5CBB71663" modified="2010-05-18" version="1">MDTLELQGEEKLIEVSHLLKTLRSDLDQKSLQTSQLIETLQKLRVHGRKLENADPIYEKEGIATLSTYGFDEPDAIIYREALRCLANALLLEKATRQRFVDLGNGRKAAEKLKEENSDDEFLCSRLLFLTTYDSDLDFDKLFSECSLGESINNHIYRHSKQFSKGKKKKLTPIDELALSETLKLMFNITNYYPHQVAAFSPSIPHILKILSRIEIPTPPLQAPVNYLVNSLLNLDLAAEKSKPFSTNPLFPKFDQNCNVDKLINILDQAVAMHKPSDLETLAVPLLTLLRKIYSFAPEGPRKYMEWLLLPEDNDRDLPIGQSNTLSSRLLRLSTSPVAPSLRDGISALMFELSGSNASEFVRNVGYGFAAGFLMSHDMAIPESAKEAYSSKGNKEFNSAINPITGQRFDAEPVDNGPEMTEEEKEREAERLFVLFERYCLLDSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZH0</accession>
    <name>D4CZH0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysozyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025572.1">
        <property type="nucleotide sequence ID" value="XM_003025526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZH0"/>
    <dbReference type="GeneID" id="9581810"/>
    <dbReference type="KEGG" id="tve:TRV_00212"/>
    <dbReference type="HOGENOM" id="CLU_1020106_0_0_1"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29835" checksum="65B70B8E0EB29993" modified="2010-05-18" version="1">MNSLLRERWSKGEMIKRVGSYTYSDLRGNKPGRRGLYKPRQNPSMKISKQARQQRRKQQQQQSQPNSQFQPPFKSTHSSIKMRSAIFISAISFLPAALAAPMQISARDCVGPDVNPATIALIKEFEGFVPAPAPDPVGLPTVGYGHLCQSKNCGEVGFPFPLTEDTATQLLIQDVKAPQQTITLKTADGVHLNENQYGALVSWTFNVGPGNVATSSLLQRLNALEDVNTVLREELPQWKYGGGKVLPGLVRRRAAEVALGETASDVPALPVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZV0</accession>
    <name>D4CZV0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_00343</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:61929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61932"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82897"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>fluconazole(in) + ATP + H2O = fluconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46081"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:61917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025474.1">
        <property type="nucleotide sequence ID" value="XM_003025428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581710"/>
    <dbReference type="KEGG" id="tve:TRV_00343"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1218"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1255"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1408"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1470"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="114"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="805"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1493" mass="166418" checksum="353910D2A78FBC4D" modified="2010-05-18" version="1">MASNTVGANPSKSENPSETSDSDTIFASSDYERERENLRNANRQGLTQPTGGVDIQKAEEEFAVLSKELSRISEKSKRPFIQEQNGLNEKGSYDVESGSESKSAFDLEAALHGSREAEAAAGIRPKRIGEEIKILKNFRGVAKPGEMVLVLGKPSSGCTTFLKVIANQRFGYTGVDGEVLYGPFDSEKFAKRYRGEAVYNQEDDVHHPSLTVEQTLGFALDTKTPGKRPAGLSNLAFKKKVIDLLLKMFNIEHTANTVVGNQFIRGVSGGERKRVSIAEMMITAATVLAWDNTTRGLDASTALDFAKSLRIMTNIYKTTTFVSLYQASENIYNQFDKVMVLDQGHQVFFGPIHAARAYFEGLGFKEKPRQTTPDYLTGCTDPFEREYKDGRNETNAPSTPAELVKAFDESRFSEDLDKEMALYRSTLEVEKHIQEDFEIAHHEAKRKFTSKSSVYSVPFHLQIFALMKRQFLIKWQDKFSLTVSWVTSISIAIIIGTVWLKLPATSSGAFTRGGLLFVSLLFNAFNAFGELASTMVGRPIINKQRAFTFYRPSALWIAQVVVDMAFSSVQIFVFSIIVYFMCGLVLEAGAFFTFVLIIITGYLAMTLFFRTVGCLCPDFDYALKGVSVLISFYVLTSGYLIQWHSQKVWLRWIFYINPLGLGFSPMMINEFRRLTMKCESDSLIPAGPGYSDIAHQVCTLPGSNPGAATIPGSSYIGLAFNYQTADQWRNWGIIVVLIAAFLFANAFLGEVLTFGAGGKTVTFFAKESNDLKELNEKLMKQKENRQQKRSDNSGSDLQVTSKSVLTWEDLCYEVPVPGGTRRLLNSIYGYVEPGKLTALMGASGAGKTTLLDVLASRKNIGVITGDVLVDGRPRGTAFQRGTSYAEQLDVHEATQTVREALRFSATLRQPYATPESEKFAYVEEIISLLELENLADAIIGTPETGLSVEERKRVTIGVELAAKPQLLLFLDEPTSGLDSQSAFNIVRFLRKLAAAGQAILCTIHQPNSALFENFDRLLLLQRGGECVYFGDIGKDANVLIDYFHRNGADCPPKANPAEWMLDAIGAGQAPRIGNRDWGDIWRTSPELANIKAEIVNMKSDRIRITDGQAVDPESEKEYATPLWHQIKVVCRRTNLSFWRSPNYGFTRLYSHVAVALITGLTFLNLNNSRTSLQYRVFVIFQVTVLPALILAQVEPKYDLSRLIFYRESAAKAYRQFPFALAMVLAELPYSILCAVCFYLPLYFMPGLSNESSRAGYQFLMVLITEIFSVTLGQVISALTPSTFTAVLLNPPIIVIFVLLCGVAIPKPQIPKFWRVWLHELVPFTRLVSGMVVTELHGQEVTCTGLEMNRFTAPSGETCGSYMEKFFANNGPGYLVNNTTNMCEYCAYKVGDEFYRTFGMSFDNRWRDLGIFAAFIGSNLLLLFIGVSIMSFVKHGEDLSLLMSILVSLDISISTDDKWFPPIDTPRAKSFHLLFGCIYSSSSFIDCLILRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D093</accession>
    <name>D4D093_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000024">
        <property type="protein sequence ID" value="EFE44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025349.1">
        <property type="nucleotide sequence ID" value="XM_003025303.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D093"/>
    <dbReference type="GeneID" id="9582960"/>
    <dbReference type="KEGG" id="tve:TRV_00488"/>
    <dbReference type="HOGENOM" id="CLU_2856135_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="65" mass="7516" checksum="0FE65A747F350AF5" modified="2010-05-18" version="1" fragment="single">KKKKKKKKKKKKHAQQRPNLWPQPPSLSSPSLCLLLRDHRPALRDEQHNPHKQAAASQLRALPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0C5</accession>
    <name>D4D0C5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_00520</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="ACYE01000026">
        <property type="protein sequence ID" value="EFE44697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025308.1">
        <property type="nucleotide sequence ID" value="XM_003025262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582920"/>
    <dbReference type="KEGG" id="tve:TRV_00520"/>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="16">
        <location>
            <begin position="269"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="125"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="658"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="823"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1138"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1149"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE44697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1368" mass="151900" checksum="F9C031E7D58D52A5" modified="2010-05-18" version="1" fragment="single">IVPMQADVDGQPDKSPLCSKDRGAPKQEPKPGQETRREVETETGTLAAQSPNTESTLLELIPQPPAVPSSPPQPLSQSQPEPLVPPIEQPVDSSYTSTYQRNPRYLTDRDGNRVSFSSLYSLTSSIHSAPGDRERASSTAVSSVDGSGKPRSTMDDQRSVSAGLSTRPDSSLHTPSGYSGQGTSSSPGSTSPGLTPSFQHHLAKPEDSRSPAWISRPGRSSSKQPRRFSASTGASSASEAEGTTPPLFSRALGPEGLLIHTVRLPLIGRIGVCALDVKARSKPSRNILTRLQARGDFEVIVFGDKVILDEDVENWPECDFLIAFFSDGFPLDKAIAYANLRKPFCINDLPMQQVLWDRRLCLRILDQMAVPTPKRVEVNRDGGPTLASPELAQHVYNLTGVRLEGPPDGTGGGTPRTQSVTMSEDGEALIVDGKVFKKPFVEKPVNGEDHNIHIYFPNDQNYGGGGRRLFRKVGNKSSEYDPDLKIPRSITEPDVSYLYEQFLRVDNAEDVKAYTVGPAYCHAETRKSPVVDGLVRRNTHGKELRYITNLGKEEAAMASKISNGFGQRICGFDLLRVGDASYVIDVNGWSFVKDNNDYYDKTAKILRDMFTREKMRRDGKLDVTEPAKDPSSSIPPAINSGSHRHTLKSLLKSPSIAGLQSGFSSHKSPAQTPSTKSTISSKVETDDLHRKPSHSEGSEKANLSPDTQLTNEPSQPVEAPTAPPPSSKHSWKLKGMVAVIRHADRTPKQKFKFTFHTQPFVDLLKGHQEEVIIRGSTALRSVTNAVNLALKEGIEDKEKLMLLKRSLDHKVEWPGTKVQIKPMFRRRNSQELQGSRTPPPVSPLTTSEIPPAPASPPDSADPEHPRVARSDSLSGPTFSRFSAVENDLVLDKLQLVIKWGGEPTHAARYQSQDVGLTMRDDLKLMNKEALNDVRMFTSSERRVSTSAQIFASTFLDQKDLPDDFIQVRKDLLDDSNAAKDVMDKVKKKLKLLLREGNSAPPQFAWPKENFPEPSIVLSTLVELMKFHRCVMRHNFQKIEAHGNYHPGAFGSSSPTEKSPFTDIQGRWCAGEDPQLFKERWEKLFKEFCDTEKVDPSKLSELYDSMKFDALHNRQFLEWVFLPPDDFIYEGETDKERAGHVTSSHFLEPNGNAEGNGTNGTNGKPRPPAGLLAPLEDSYDSYFKLYPGSTPSKPKIDKRLSRLKHLYSLAKVLFDFVTPQEYGIADHEKLEIGLLTSLPLLQEIVMDLEEVQASPDAKSFFYFTKESHIYTLLNCILEGGLKTKIARRTIPELDYLSQICFELYEARDAEAETFAYSIRISISPGCHTFDPLDVQLDSRHAIGCAPRRSLTAHQDWKEVIETLKAKFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0C6</accession>
    <name>D4D0C6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000027">
        <property type="protein sequence ID" value="EFE44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025307.1">
        <property type="nucleotide sequence ID" value="XM_003025261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0C6"/>
    <dbReference type="GeneID" id="9582919"/>
    <dbReference type="KEGG" id="tve:TRV_00521"/>
    <dbReference type="HOGENOM" id="CLU_036236_0_0_1"/>
    <dbReference type="OrthoDB" id="4174352at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="584" mass="65858" checksum="4351961372EDC874" modified="2010-05-18" version="1">MWALSSEVWSVINKITNRKPLSYTNYEVAQCSSCLDHEHYLCGDEKSVCGRFAQNVLGPVTAVAFANGVKARFGDFKVCAESQGEIDVPDFVAVHCTAKNLHALEQLDSSEVPYLKFVGEAKTPWRHDLGKIHHDFTTRKKSTIDRALGMFLSAAIHEDESVLIQIYEGQIAKYMYDHKMRYGFLTTYDETIFLKQECFEGSTWGLLISSPIPFDTSANWETRTVSLRQCLYYLMCVTEEPKNRIANNTTPRHKWISDKSPKDLTQPQLHTPVSQKPQAPTELLQHLSQSPELKTDLSSLTDRIKLHHIPSSGIYSAILQFKHEDIRTEGNRSYVRVGDQWIQAEIITYGQSHRSKDAESSSLGHGFSSSPSPSARLRAQEYGGNTPSKHRKEKVSLMERMQNPKPFQYTDSNYESGPTLSVDTPTRLPSQPQGHGIPAPSLPHYPVPPARQYRSLSRDTSGMRGTFHSPYAHFSTEQSPPRDLSQTREMTLPHRPPPFGHHQSLSRDPSMEPGQGGSPDRRVERHDSGSRDKGKGKAKERLDSTGGYNLRSRSDKGESSKGRGKDKDDDEKRGRFPGPFSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0P2</accession>
    <name>D4D0P2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025182.1">
        <property type="nucleotide sequence ID" value="XM_003025136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0P2"/>
    <dbReference type="GeneID" id="9580675"/>
    <dbReference type="KEGG" id="tve:TRV_00637"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="34989" checksum="D8130BEF06E9FEE2" modified="2010-05-18" version="1">MGAQFSQFFPPKPNWTEAKVGSQDGKVFIVTGGASGIGFELVKMLYEKGGKVYIAGRSKEKAQKAIEEIQAAIPNGGSLEFLHLVLDDLSTIKTSAEVFMEKESRLDVLWNNAGVSQPPLGSLSKQGIELQLATNCLGPFLFTQLLLPLLETTAATSTPGSVRVIWTGSQIVELSAPQGGIIMSELTTPPKDQTRTYITSKAGNMFLASELARRAGPSHNIISVSLNPGAANTNLLRHSPWMKFLAMPLLYKPKLAAITELFAGLSSDVNLEENGCYIIPWGRISRSVRQDLVDASKSTEDGGTGRSQEFWEFCEKKTTDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0P3</accession>
    <name>D4D0P3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025183.1">
        <property type="nucleotide sequence ID" value="XM_003025137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0P3"/>
    <dbReference type="GeneID" id="9580676"/>
    <dbReference type="KEGG" id="tve:TRV_00638"/>
    <dbReference type="HOGENOM" id="CLU_013935_2_0_1"/>
    <dbReference type="OrthoDB" id="4170482at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="642" mass="72222" checksum="FC096524A4F9F829" modified="2010-05-18" version="1">MACWKNRSCKEGDLLRPASRDSAKILDYSYNTWHQLLWSAEAKAQLPDACSSIRALLHSTPAIPDTSKISEFAEDHSLFLEGYSIWSINSTSPCSLTTETKKARPQTIRIGVLKPTFCSLSENFLPEWPGFEALPDASGSNFLSVFVLGWSYVLSTRLIELRGNQHDQAQYTNNIAIMANRSGGLNLNTGYELPIGDATAQESRWWAAILSNGCGWLATLTRQDKEYYAPWSCHLKDGGKPFTIIHDKSELIISSERDPPSSAQAQSYLLRVAEMHDIFDQLLAAFTAVLTIPYHMRFGAPVNLPEPHLHTRPKKQSTIGYKQKIPTFDELPYFMSFSTIPNVISSCLFSCFWEVGIPCNLASEWLHTPLSDILPALILERKHRSIIQMLATRSPNVAPLLLGSAITGMLHRIPEVYKSFIPPICLEAAVWSSSQQSFMDPVFHHMPKLRRNIAFKKLITREDEFRILYTTDFESADYPALPLSPYPPFGHWVWQGQDSGEVRCLDDYGFTLSGNISSFPAHGKTGCTISQLVNRALLSVTRKLSTCWTDFIPGPQRTSNGDINERLSEVATRNLFSWTLFSDGVRKEDKELWHHEWLEFLLGVDDNASETDSNLTSINGQSKSAISSWLQTVFMSHAIQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D162</accession>
    <name>D4D162_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-binding enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025005.1">
        <property type="nucleotide sequence ID" value="XM_003024959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D162"/>
    <dbReference type="GeneID" id="9580497"/>
    <dbReference type="KEGG" id="tve:TRV_00810"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055158" description="AMP-binding enzyme" evidence="1">
        <location>
            <begin position="17"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="400"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54783" checksum="7228610B8CF339E9" modified="2010-05-18" version="1">MSIVILLSILAADGIALPLSPSFPAAELRYILDNSQAEVLLATERYREQAEQVLKGELINPPVLEFIPKLEKGATPPSSVGFRNIEDPQGGMMLYTSGTTNRPKGVFLPHSALAAQTKSLVEAWSYSPDDRLLHMLPLHHIHGTVNAILAPVLAGSSIEFTYPFNPTAVWKRLAKPFLPQSTANPPPKPINFLTAVPTIYHRLLNTFDLLSDTTKQAAKEAISPGNLRLNISGSAALPTPTKGAWSDLSGGNVLLERYGMTEVGMALSCGLEFNDRIDGSVGWPLPSVEVRLFDLDKQEVIRPGQELDNYGRERVGEIQLRGPTIFKEYWHNKQATEESFTDDPDGKGKWFKTGDMAIRKPVDGAGKGESTWAKGPLYFIQGRQSVDIIKVGGEKVSALEVEREILSLPQVLEAAVVGLPSKQWGQKVAAILVLDAKHAATESDEGKPWGILDLRRALKEKLSSYKIPQEMRVLEGGIPRNAMGKVNKKTLKKEVFGDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D166</accession>
    <name>D4D166_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025009.1">
        <property type="nucleotide sequence ID" value="XM_003024963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D166"/>
    <dbReference type="GeneID" id="9580501"/>
    <dbReference type="KEGG" id="tve:TRV_00814"/>
    <dbReference type="HOGENOM" id="CLU_045406_0_0_1"/>
    <dbReference type="OrthoDB" id="5368934at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="449" mass="50543" checksum="3196B6623EF1A47F" modified="2010-05-18" version="1">MVCCRGCRRPINQDEDSDENNHKQVIAGASFQKRRSSVSDITCLPFGLTKSESLASISRFFKAGSSSNAKKGATARSASRSSFSSNIALLRSAFGGKQNNMKEYEDTFEEPFEDDDSMDGFDKPIISFRGGSAWQALDLNCKVLALDLFWPTKKNSPFDNPFRPDIMPVEELASLCNFRNLRKLKLTGMSQSYQKYIWQTVWLNPALEELELEMALEPCIRRTFNADWPSIKGDWSYRTADEMPGVYYGESGEGELHRRAGVGEYLDKESIGEAKIRALAMGCTLDRLPIVKLTLTGFVVDADPFFMWFNPHRLRVINFKNDCVDAGFAIPRFMSDRVVVSWPNTVAEYAMQVRHVKPGEVKLIDIPKRKNKGPTQAKLVDIPKKGKNPADKADETKLANEKVSEWRKASIGKENAAIEKAPKCFSDNDDGLSRRPAFRIKGFPRASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1C0</accession>
    <name>D4D1C0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024949.1">
        <property type="nucleotide sequence ID" value="XM_003024903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1C0"/>
    <dbReference type="GeneID" id="9580441"/>
    <dbReference type="KEGG" id="tve:TRV_00869"/>
    <dbReference type="HOGENOM" id="CLU_009129_2_1_1"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="272"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="584"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="786" mass="85484" checksum="D2E133EDF100F82B" modified="2010-05-18" version="1">MSSVPGSGSGAGTGAGSGAGNGSSTGLPASTSPYPLPTTAIPTIYRTRRSSYASVLSRQPGQAEHEHDEHYPPSPFRSSLTASSSTNNNAIQDTSSSRSRNQVPFSSSAPPADPAAMQQQTNGSGAGAGSTTNSWRRPNSNISFQLGQGIGMGQLPSYSKQFEKLLEQADLNALPFGLNNSLYQQNPEDSFFTPSYLRSSKYVAQLYAAHKAKLSSQRDAQSQNQHTPTPGSSAQHLPSASSLPLSASSSQLNLHRMAPSHRGMTYDIVESHGPGGDSTAPLEGQQLTPLPSRWNESDKYSGLDLLGEGLEVRYIGHVPKQEHEAAAVRADQPMPVKCGIYYFEVTILAKPKDGMIGVGFSNNKASLERLPGWEQESWAYHGDDGKTFFGDNQGQGRPYGPTFTVNDTIGCGIVFSTGNAFFTKNGSFLGSSLLMAMAGNAFRDLKPAKLYPCVGMRKQPGAHVKANFGQFPFIFDIDSMMASEKYDVQQNIQRTDLSTLHPTLDESEFMQKLVAQFLAHDGYVETAKIFAQEVQDEKRALQTSGEMSMKELEVEDDIDAINRQSTPRLHLFPIRWYQLTSCPEIRAAILEGDIDRALKLTNVHYASVLGDNPHIHFRLRCRKFIEMMRRCTEPQPAAINSSNGLSEPTRTTSDGFTLDMEVDDQMPDVDANEAIAASDMMDTDAGNTNNANNDTTTVKKDQDLLHEAILYGQQLQADYPGDEKKEHKKTLDDIFSLVAYADPKTSVHGHLLDPSGRVAVAEELNSAILGNAPPRLFPTASTNRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F1</accession>
    <name>D4D1F1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024980.1">
        <property type="nucleotide sequence ID" value="XM_003024934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F1"/>
    <dbReference type="GeneID" id="9580472"/>
    <dbReference type="KEGG" id="tve:TRV_00901"/>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_1"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="1">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="250" mass="27206" checksum="417C038F4C24AC1F" modified="2010-05-18" version="1">MSIYIPRVYVYKRPIFLPLRGICPPPQPTPSSSSSSRYHLHSATAKMKYTFLAVLSAVTVLATPAPVPTPPNIPSASTAQSLLSGLTVRPQGPQDGYSRDKFPHWITISGTCNTRETVLRRDGTNVQVDGSCAATSGSWFSPYDGATWTAASDVDIDHVVPLSNAWKSGAASWTTSQRQSFANDLSNPQLIAVTDNVNQAKGDQGPESWKPPLQSYWCTYSRMWIKVKSVYDLSVTSAEKSALTSMLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F7</accession>
    <name>D4D1F7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024902.1">
        <property type="nucleotide sequence ID" value="XM_003024856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F7"/>
    <dbReference type="GeneID" id="9580393"/>
    <dbReference type="KEGG" id="tve:TRV_00907"/>
    <dbReference type="HOGENOM" id="CLU_047454_0_0_1"/>
    <dbReference type="OrthoDB" id="5359669at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="380" mass="41327" checksum="2DCD306E823BAEB4" modified="2010-05-18" version="1">MGPSLFNNYFNGPTVALPPPSQLHQTNQLAPTDSMNHSFAHSGGSRFPHHASAHADGIQSGPPKSFIGRQTPLNATQCTAAPSRKRSRDEFNLSNNDNHNNFAVQKALTPPTVPEEEPIYGEGMVLINPKTGLAISASSQTGTWYEEKAEEKAVSNQISVPITADVNHDHINPLPSRKTQRLDATASAYDDITALSIANKLQSNTDDVCGSGSSPKGPEMPHVDDATRLLGISWQRMANDDKDMVAAIRGWEKYINNHFSTHLHDAQIMLKHRGLNVYLVSALPKGQHQNENAARRHFYLFDDNLTEGQLVGRDWQSSIRNLQSSPIAFEAGSAVLKAAEKTPERQVEDKGIPIATGGMNGCMMGTTGTSTGTDIQMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R4</accession>
    <name>D4D1R4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024842.1">
        <property type="nucleotide sequence ID" value="XM_003024796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R4"/>
    <dbReference type="GeneID" id="9580320"/>
    <dbReference type="KEGG" id="tve:TRV_01007"/>
    <dbReference type="HOGENOM" id="CLU_089696_4_2_1"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="244" mass="26719" checksum="81ED06F24444D315" modified="2010-05-18" version="1">MPATAREAVLRNETWDRGTATVYSSFLEKLLKLLKLKVKINDDDDDETTIRSKRREKRRTALSDSQIIVINPPMKQIPFPFALNVGTDIVHIPRIQRLVARSVAASTSLDPAAATNQKTSLSRFVRRILCEQEQAYFKSKFKLSSVASDVQLPSQPITAQTSTEIARWLAGRFAAKEAARKAAPGGAASVSWKEVMIRAEAGGDGRPEVVYLREGGSVGQLGKLSISHDGEYVIATVIAATPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X4</accession>
    <name>D4D1X4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024727.1">
        <property type="nucleotide sequence ID" value="XM_003024681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X4"/>
    <dbReference type="GeneID" id="9580217"/>
    <dbReference type="KEGG" id="tve:TRV_01076"/>
    <dbReference type="HOGENOM" id="CLU_559210_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="462" mass="51479" checksum="A529574291166E50" modified="2010-05-18" version="1">MLHLLNHRSDNSEDCEKCFACLLGRLVDEYWTPNPSLKLELIISRLWKECSQFWDTRSTDQQDCIEFLTRLISQIDNSTDTGDIQHIFQNVFKYRSTCQTCQHTKYSEKDHSWVLGASPPEQRLGSLEDCIQEYMRPEEIAGYHCDNCGSNSTLHREMFIKDAPEVLVIQITRFKVSESGESSKVTAEVQFAEDLDLTERLLPQAREFGDTLRYQLTSVIVHRGATIKEGHYMSYVKGPRGTWTCLNDDFSCEADINVILRYQDDNNVPYVLIYNRLPLFRGSPGAINNDPAMTGSYSLAGRIEPYLLANANETPTDEHGVPKRIITPGQGEEATVEVGDGSTDLIEVLRSSNTGLSGSPDSIFRWEVQPAKVDIEITMGGRVFRGAVQGLFESGQKRPRPDDLREAGAMQEGSVNLTPSPLGGNNGGKKQCLPAEKNGASPKVTGQLVPRPSTRRGLIPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Z7</accession>
    <name>D4D1Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024750.1">
        <property type="nucleotide sequence ID" value="XM_003024704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Z7"/>
    <dbReference type="GeneID" id="9580240"/>
    <dbReference type="KEGG" id="tve:TRV_01099"/>
    <dbReference type="HOGENOM" id="CLU_004219_2_1_1"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="527"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="702"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="820" mass="91862" checksum="988F9FFD7170FC35" modified="2010-05-18" version="1">MLDTPGTTVLTYTPNGKQLITAGSNSGIRVFSTGEHGEPKTIDEGMESHLAIAATNESMILGSEDGTVWLYKLQEATMDKPLARCALPVRDLEVSKDEEWVAVASDELTVKIVNINDITEVKYLRDQTKGVKHVTFDPSGRFVTVSCADGIIYIYSFTETEPTLLHRLDGVIRQLETDNEATSSAVWHPDGTAFAAVEATRDITVISCRDWTKQRKFSGGHNGDVTCLAWSPNGAMLASAGTDRKILLWETRTQKVIKTYDMPNAINFRWHPTQNIVAFTTSDGELFIYDDFVPSEFHSLLAKTLEVAPLLSIGSHEEITISHRPQRHDTSNLSGNRPRGGSPDSLDDILGPADDDDFVEDDDGAGYTENVNGLGKRTNTHMDELFGHETKRRPTAPWKTISHEPFQPGSTPWRGNRRYLGKLVIVYFGRVLVNETVALNLVGFVWTVDQDTHNTVTVEFYDRERYRDFHFTDPYLYDKACLNEKGTLFSCQPTSSYPAAVFYRPHETWTTRADWRTELPPGEKITLTCAAWRDYIITIGNGPAGSDGVAQLKYSIENVRRDEICQNEDAVALAGGTRLQSVFFSDKGDPCIYDSSGVLLVLQHWRKPGQARWVPLLDTKVLERVASGRKEETYWPVAVAQDVFHCIILKGGDKYPYFPRPLLTEFDFQIPISCTSSKEKSNKDGDMEMEDAEEAARNNNRKLQESLVRANLDYTLLEDCITASEIGAAGDAELRRRALDIDKILLQLLAVECREGEERGMKALELVTMLRDRSGKMLDAASKIAQRYQRSILDDKIRAIAERRLMGEDDDGITGDNNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D222</accession>
    <name>D4D222_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024717.1">
        <property type="nucleotide sequence ID" value="XM_003024671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D222"/>
    <dbReference type="GeneID" id="9580207"/>
    <dbReference type="KEGG" id="tve:TRV_01124"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="374" mass="41746" checksum="42BBB6651918BE5F" modified="2010-05-18" version="1">MLNMSAAQDNPGRGPLIMGLTWAFAVLATITVGLRFYIRVELNNRPSLDDWLIAIALIFNFVSQAFVSVGFTYGLGKHDANLQPNQIINILKWMWLANTPGLLVAITARLSIAMLLVRLFGKVHKWLKWFLVVVSGLCTVLTAIIIPCTFLQTTPVSGNWNPFQPSKRWNPMIYISLAFLTQSLWTFTDLTFVLFPVIIIWRLQMSLGKRISLVLLMSASLLTMSVSILKTISLQHIANQQADPTATDVQYESSITILWSCLEQAFVIIMGCVPTLGSFTKLKVAQPLMTSLDSVLRLINPFKRSIVHRAVKGNGTNSQNYENLEMPKAISGWSDGLYGPVLDKSLSALEANPLELKQNTGVIKIKPEWKKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D273</accession>
    <name>D4D273_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024658.1">
        <property type="nucleotide sequence ID" value="XM_003024612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582833"/>
    <dbReference type="KEGG" id="tve:TRV_01175"/>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="11">
        <location>
            <begin position="1354"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1946" mass="219576" checksum="64BCB1165A566992" modified="2010-05-18" version="1">MLLFSSVANRILSSSPPFESAWDGSLSWLARMVYGLQSRRSLGKQRDIKTRDVPLSSLIPSHLASHLAADTSGEYGIDRETFSQLRREILSQSEEGEANTNDNINDIYNLICVVVRAGFEQSSKPRGPRALGDDIIGQILDCLDIIRLAVQRAPAVLNGSAKPEFIKENTLQLPLFVWVLSSLLTLLCSRDDRSIQDKVCQVVSVIYGTQFKTIRLWYSVKSISRFLQACIGVPTVEFLSCLDELGLPRDCCGKIELGNSQTVAIACLRLIETITFPVELPLTDSKASLLRESFNHGLHFAVRLWKAIFEWFDENTVAVGEQSLTSLLVEFVSFSRKLCSYSTRLSSRIDQKVLLPLFQCVVDLVDPEQLKRSIELQQVLAEFLMEVIRLSQSSAGVESLVEELFFYPLSDIGANIDFFQTLHQSLQHVVLRVVAGEHRTKIGLKVVQRVGLFDKDRGSTSRSYILDRKDSSIPAVIDASTDERASKRPRLSHTEDQNGHSDLSSVISNKIYSTLGVFPPNGLEDLDEDAIEMEKCHAKKPISPLQFGHLRSIIAGILPRIEDSGSCRISAMIAIRNIVNHDLRDTEDRLDISLFGEYCLRSLKSSIRELRVAAGNFIVALEYLHKIFEKNELFLQETCVMALRQIAEISNDEEMNIVLLRLLEYLGHANPFVSGIAYTEISKLATLLRLTPAALFRPYWRTLSLLVIKNFQARPQMADQLCDLLGMEVNGFLRLTTSYTLPYLVLTRKKDIISRIAMTHSKKSISELIKTRSHLASILALLLVQPLPNPEAAIPCILQELSVKFNDPTLSKLVRSECVPITFEKSENLSVFLEEHVLGVVTEFVHVINDFQVLQPIPEKKRDIIALGEMIKIAKGNIGIALPQICACLRAALDTDDLRDLAFATWNTMILALNEVDLEPLVDQTFALILKYWEFLTEETKKKEIELVNYILRDNGDTLIAVFETLPSLESIPELSEQNKKIEHLKQVMDIGSKFMALCRRCQSDNFAVVERALVELLPNIANHEEFIHGSVFSEQPDKSLVGKVTRTLLDCCVKYNPSSPTIVLLSAQCLGLIGCLDPNRIESIKEKKDIVVLSNFERSDETLDFIIFCLQNVLVDAFLAASNSRTQGFLAYAMQALLTTGNISTAIPPRSQDPQSSDLYRRWLELPELSRNTLTPFLNSKYSVTIGAISTSCQYPLFTPALNHSEWLRTFVLDMLQKGKSRNIQILFSVFSRIIRTQEKSISVFLLPFAALNVAVSAIDEEREHLKGELTNILECPLPDHKGPERENLILFSESVFAVLDYLSRWLHGKKKEYTSITSIGNNASRSQKESLTESAVQIKRVEHLLSCIPAEIISKRAVECKSYARALFHWEQYIRQQKSRPETDAMELESLYQRLQDIYTQIDEPDGIEGISSHLHVLDLDQQILEHRNSGRWTAAQSWYELQLNKSPKDLDTQINLLTCLKESGQYGILLNQFDSLKKNEAIIPKMLPLAIESSWVTGKWGKLEKLTLDRRDEITTDFNIGVGVGLVAFRQGKKDELEKIIEELRMNVASGFTLNSVSTFQASHDGTLKLHVLSEIELLTSGSYDNPSTPRNELFTILDRRLDMLGGCIFDKQYVLGIRQAIMDLSPAYDDLEVASVWQRIARLARKANWKDQAFNAVLHSAQLNDKNSTIEYARLLWKEGLHRKAIQTLEGAISANVFGPTGRSGTSDNDASVPAKGYEQNLLMARAYLLLAKWMDSAGQTQSDFIVSRYRQAIHYHPKWEKVHYYLGKHYAKILDSEKSKPLGKEGQKYLSGEASKLVINSYLRSLTFGNKYVSQTLPKVLTLWLEHASAVDQPFDPKRGDNEDFQKHNMSQRKKNLDEMHSQLKKYISRISPALQGLWTVLALLKSSSKDRASRGITILQKITAKPEEDYCVEEALSHSILGVRQEIKNRAPSGRYSVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2G6</accession>
    <name>D4D2G6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_01271</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024559.1">
        <property type="nucleotide sequence ID" value="XM_003024513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2G6"/>
    <dbReference type="GeneID" id="9579883"/>
    <dbReference type="KEGG" id="tve:TRV_01271"/>
    <dbReference type="HOGENOM" id="CLU_006301_8_4_1"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="434"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="84"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="959" mass="105242" checksum="A9A9A31A40DBA35B" modified="2010-05-18" version="1">MDPIIIIAAIRLNLPIQPAELKQREALLASQVSQKQSHSTAESEAKNGNTAREQHATWICAQCQKANPVKLVSCPDCNWKPSRAYLTSSRSRPTQPKPSSPKTSPGNGQTSSDTRSEKQSKFTITRSWAPEQSLYRSARGRQQPQSTGQPSRDSRLGASGALSRTSGNTDTDHQEPWQETGFRSISRKPRSSLDSQKQDSTVSGSWQLSGFRSLPPQSEQVRPSDLASESEAPPVRSKPRRDELDSGNYTNEDYVDRQSSRAVRGRARDFTPSYEDADKEFSSKPRKQKGRRATTDDDLDEPPTRSNRRGASRGRDLDIMDRELEYGVGRPKRKDKKDKKKAAQRLQEQSGPTPIVLPDFISVGNLADAINVRRTQFIKSLESLGFDDVTNDHVLDSETAGLIVTEFNFEPVAESNDIDLVAAPRPDDTSNLPARPPVVTIMGHVDHGKTTLLDYLRKSSVVATEHGGITQHIGAFSVTMPSGKQITFLDTPGHAAFLEMRKRGADVTDIVILVVAADDSVKPQTIEAIKHAKGADVPIIVAINKIDKEDINIDRVKQDLARHNVSVEDYGGDVQAIGVSGKTGQGMLKLEEAVITLSEMLDLRADKECNFEGWIIEASTKRAGRAATVLVRQGTLRPGDVIVAGTSWAKVRTLRNEAGIQVAEALPGTPVEVDGWRDQPVAGFEVLQAPDEQRAKDVVAFRTEKEEVQRLGGDVEAINQTRRETRERRQLQAALEENGDTSTDAADKGGPQPIPFIVKADVSGSAEAIVNAMSAVGNNEVFAKILRFSVGKIGESDIRHASAANAAVISFNQSVDPDIMKLAVAEEVDVLNHNIIYELIDDVKMRLSEHLPPTVTQRVSGEAEIGEIFEIKLKGKKTTFVAGCKVSNGVINRSHNVRVLRGKNIIYDGTLSSLKNVKKDVTEMRKGTECGMAFEGWADFAVGDEIQTYEVVREKRHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H0</accession>
    <name>D4D2H0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024563.1">
        <property type="nucleotide sequence ID" value="XM_003024517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H0"/>
    <dbReference type="GeneID" id="9579887"/>
    <dbReference type="KEGG" id="tve:TRV_01275"/>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="585"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="761" mass="83895" checksum="F21FD239786E1DAA" modified="2010-05-18" version="1">MPPRTGTVVGIFGVLLGVILAVQLAFNFHGTSRANQFSRSLPLQSTRADKSATEDDIFNVGIGKADVTGPVVEIVFMGFADSEQKGTGLRQRLYSRAFIIENPNKPDDTFIYLVTDLAAGDTAVRDGVLKGLAAMGPEYSRYASHNLALTGTHSHAGPGAWLNYLLPQIPSAGFDKATYQAIVDGILLSIKRAHEARTPTRLSFDTKDLVDGNINRSPFSYLANPEEERKRYQYDTDKTLSLIRFDRVSDDKTTGILTFYSVHGTSLFANNTLVSGDNKGVAAYLFERAAKGDDRFADGFIAGFSQSSVGDTSPNTLGPFCEDTGLDCKFEDSTCGGSTAKCHGRGPFFRELDQGTKSCFEIGRRQYNTAKEIYENMDTSAKRIRDNSAVKSFHVYQNFDGYTFPSPFNPRKTLTTCSAALGYSFAGGTTDGPGRFDFTQNGTDSPSTKNPIWRIARDFVHAPSKEQIACQKPKKILLDIGDLTFPYAWAANIIDIQVLRVGPLFIIVATPEVSTMSGRRWKQALSNKAKEILGVSNPLVVLGAPSNTYAHYVTTEEEYGIQRYEGGSTLHGPNTLAAHVNLTLTYLPFLSASSNNHPDPGPYPPINTEKSLSFIAGVVHDNPPIGKKFGDVLKGPEMGKTFRPGDTVKTTFVGANPRNNFRLEKTYTTVERQVPNSNRWEVVRDDFDWNLVYRWERKRPIIGTSEVTLEWTIEDDYYSIDNKKKLESGTYRLHYYGDSKAPVTGQITAFEGIGPAFKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3G2</accession>
    <name>D4D3G2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor Clf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024271.1">
        <property type="nucleotide sequence ID" value="XM_003024225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3G2"/>
    <dbReference type="GeneID" id="9579391"/>
    <dbReference type="KEGG" id="tve:TRV_01622"/>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="82722" checksum="839E8E5001EAB4AD" modified="2010-05-18" version="1">MPSPKPPFELKDHCSLIHQNVLYVYSPAGFMSLALEPNAKWSKLETGRSVTGASCFKGPTDGDMNNPAFYVVGGTGGPDDYLGVQSYSFLDKKWKFPPLDGNNMKNRLDHDAVFIESQSSILVFAGSTNGNPTPSTETFMISMNSNLYHIESRGGPVAPSTKPVLLPWGKDSVLLVAGSGDNKVYEFKDNAWHMFDHVLESPITDPTNTPIIANPYIDGNMALQVFDLAASPVTVRTDSLVQPGAPHRRSIHSRHHGHVHSTIQKRDSYPAYNSTLAPTGSRTGASVAADPGYNNRVVISGGSNEEPIVIFNQDDNAWLDIKDFFSVSTTSSASSSTMTSSSMTVISSTSTPTITSAPTFTPHPTETETSSTSSDRVDDVVPPDGRTLTIIGATLGTLLGIGAIIIIILLVLAWRRRTSLYCQHAKEKHMNSDDKDRFSFQDAGVEPLTRSIQPIARGPVPSTDSWAYVAGQVDDYSRASLNPKPPAPPPTRGMPISEKSPSPLRAMETTQEERPDSDVYPPVSTNKPVFGAVVDHRQSEADDRLTDEGWSKYFQRDKDNGSIKSRASSVDSKYSKSDYKSDYQSDYRGSGWPHVSAEVPPLRFGGPQPLGMVSSGSPSTETPPKWPFTQHQGMAAKISSADSISINSDDFYDDRRDTGRDTLRDTKSDAFSTGAPGSTHDVDRWGRVSREPRVPSSNYSNSVYYDNPGPPYAGGPDRYLNPMHPESRAPSSYYGRNTRSASRGILSSDISWLNIGNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3L6</accession>
    <name>D4D3L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024177.1">
        <property type="nucleotide sequence ID" value="XM_003024131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3L6"/>
    <dbReference type="GeneID" id="9579215"/>
    <dbReference type="KEGG" id="tve:TRV_01676"/>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="235"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="47116" checksum="9DA769B7F280F1B9" modified="2010-05-18" version="1">MLASAGDDGNVLLWVPSETQTQPAFGQDALDDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEYVATQSSDRSVHIYALKTNDGQFTLTTHGKFLKMDLPAKRVASSSPVPDFGGNRVQSASGNPMTVSSPGASTPGTPLTAPLPMDPPPVSLSRRSSFGSSPSIRRSASPAPSMPLPAVKPLEAASPGLFGGIGVKNASIYANETFNSFFRRLTFAPDGSLLFTPAGQYKVSLAGQNDKVVEDIINTVYVYTRAGFNKPPIAHLPGHKKPSVAVKCSPVYYTLRQGTKPTRQIFLDSSSGEEAFPSLPDSVISQPAMEPPSSAPPSATSETARSFPQLGTNENDTGSQNTPIPPVFALPYRMVYAVATQDAVLVYDTQQQTPLCVVNNLHFATFTDLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3N2</accession>
    <name>D4D3N2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024134.1">
        <property type="nucleotide sequence ID" value="XM_003024088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3N2"/>
    <dbReference type="GeneID" id="9577131"/>
    <dbReference type="KEGG" id="tve:TRV_01692"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25235" checksum="1884A3FD786EFA9B" modified="2010-05-18" version="1">MSEYAFKAITAANITSLGIRGKNCAVIISQKKVPDKLIEPSSVSHVFKISPSVGCVVTGSIADGRAQVTRAQSEAAEFEYTFGYEMPCDVLAKRLANINQVYTQRAYMRPLGIATTLISVDSENGPQLFKCDPAGYYAGYRATASGPKQQEVTNLLEKKLKNKEDGGASWEEVVELAITTLGTVLSVDFKKGEIEVGIVGGPRADGNEGTQTAFRTLTEDEIEERLQAISERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4N7</accession>
    <name>D4D4N7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023857.1">
        <property type="nucleotide sequence ID" value="XM_003023811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4N7"/>
    <dbReference type="GeneID" id="9582469"/>
    <dbReference type="KEGG" id="tve:TRV_02053"/>
    <dbReference type="HOGENOM" id="CLU_060400_2_0_1"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="8">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24574" checksum="D22585C28F8B7FD2" modified="2010-05-18" version="1">MQRLVKVDGKVRTDSTYPAGFMDVITIEKTGENFRLIYDTKGRFTVHRIQAEEAEYKLGKVKRVQLGKGGIPFLVTHDARTRWTKVWFDSRRAWSERRWQLNIRYPDPSIRVNDTVKIDIATGKITDFVKFDTGVIAMATGGRNMGRVGVITHRERHDGGFGIVHIKDAIDNTFATRESNVFVIGQEKPWVSLPKGKGVKLTIAEERDRRRAMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4R0</accession>
    <name>D4D4R0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023787.1">
        <property type="nucleotide sequence ID" value="XM_003023741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4R0"/>
    <dbReference type="GeneID" id="9582360"/>
    <dbReference type="KEGG" id="tve:TRV_02076"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36624" checksum="4DBD10EE891B2838" modified="2010-05-18" version="1" fragment="single">LENDRLGEYPSLSISLECTSANGAMADMQHAVFLRSLDGRLCLCPIKQDIQNVLDVGMCRPNHQTVREGFEVYINSQHIGTGTGVWALDFVYTYIHTYLIPGFSASTHLFLDHRYRPVTDPTESVCDYSIVCLCGGVPPNLSFLIDDVEAEWQFHQKFDLVHGRMMTGSLKDWDRFYTQCYDNITPGGYVEMQDICLPLKADDGTLTADHALDKWSRLCLEACEKLERPLDVAKSHKSRMEAAGFVDVVEVVHKWPQNSWAKDPKLKEIGNWTMTNMLEGLQALTIGPFTRGLGWSLEQVEAFLIDVRNDVKNRKLHVYWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D529</accession>
    <name>D4D529_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023690.1">
        <property type="nucleotide sequence ID" value="XM_003023644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D529"/>
    <dbReference type="GeneID" id="9582238"/>
    <dbReference type="KEGG" id="tve:TRV_02199"/>
    <dbReference type="HOGENOM" id="CLU_010591_5_3_1"/>
    <dbReference type="OrthoDB" id="4182065at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="366"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="416" mass="46688" checksum="A698C5F349F984FB" modified="2010-05-18" version="1">MIAEWANDKNGSASHACSECELGIQHIRLSSPFVFSALTSSCGVQGYTYDIPAQYALNWTGPFPDRSCDHTEITAQPNDTCINLSGSHSVSTFHLIQKNAMDFACNDLPRRSHYLCLPLHCKTHQLGSVEDCNSLVEDFNITMKELLKWSPMINSNCTNLDSWRGWHLCTSSPTSTIPYREDGSLKRPERKLPTPPTPNPLAPGTIEGCYRYENANEEESARDASLNVCWWWAAKGEVKVEELLAWNPSLRWGEGCYLKPGYRSGYNRQKYATKIKGQRFSREIESANSSIEYLSCSKIPDYTGLSLSELRTLNPWIEKNCKEDTFTSKLSEDGFLQLCLERSNPDLTPLSLPNSIQPAATTICKEWHIVSEGDTCQSVIEKYGISPDEFSSWNPGIRNDCSTLWVGYGVCIGVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5C3</accession>
    <name>D4D5C3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023546.1">
        <property type="nucleotide sequence ID" value="XM_003023500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5C3"/>
    <dbReference type="GeneID" id="9577018"/>
    <dbReference type="KEGG" id="tve:TRV_02293"/>
    <dbReference type="HOGENOM" id="CLU_035264_1_1_1"/>
    <dbReference type="OrthoDB" id="4175458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="296" mass="32691" checksum="B47B261FBA970D27" modified="2010-05-18" version="1">MASLASADLEIGGNEQKVKQEYLAIITDAEKEQKMVCWVVEALEDEIARLAPFSSREKASFSVQGYYRPEAGFIYKYKLVNKDGYLTPIPLPGDTVKNVGCSGVKISDLAESRQNVHLIDASKVEIVSSLVPSSDKVKLEGKEYSFKHVRDSHCFDRELGILQKLVSLGLNKRLRVPTLCGVVAYSDEQDVICGILLEPIGSKGWLGTTESEGFSNEQRVKWMAQIEEVVKQLHAHGIIWGDVRPENVLIDKADNAWVTGFGASESPRFVDGGMIGTVEGDMQGLAKMRDYLGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5C7</accession>
    <name>D4D5C7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023550.1">
        <property type="nucleotide sequence ID" value="XM_003023504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5C7"/>
    <dbReference type="GeneID" id="9577022"/>
    <dbReference type="KEGG" id="tve:TRV_02297"/>
    <dbReference type="HOGENOM" id="CLU_575136_0_0_1"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="54038" checksum="DC00216B30563BFE" modified="2010-05-18" version="1">MEHTECHNGVHECVPAYLRASRPLKIFTELYIEIKRNRIRDIERHIELITAKHSLVSPPGDITLEKEILEVWAMLFDFVIHTEFNNPMLDSAVLLLINLTHSVPISQQVHDPNARIPQSLRNLNKLWKDGTGQDIKFFVKKRKPTPKTREPSEGGILLPTTEEDSDKPNDKNEENGKAEKQAKNENCTSTGATLPDSDKNEMIRSEVPMVREIIRVDGHALWTELPLLHTFLDKQFLMIGRLERKQRWSLASFLGRMIAGGLSDQYFGCMALWFIRETLETPRAIIEEKEDSDEDNYGSYNQEGEAKNNKRQAKEKKKHDQGKYDTMDMIEKEFANLTLNDLLFPCIALFSTCSKTLAALSVSSPTISGAGKNRLTNIGELATNFVNATEEGFSVQRWMFWKSRLKKIANLGVRPLSGSARLAFNLLCNSGRLSGIELPGDREFMKRLVEYLAGEGTLVDLFNSDLNWIDEEICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5E2</accession>
    <name>D4D5E2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023565.1">
        <property type="nucleotide sequence ID" value="XM_003023519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5E2"/>
    <dbReference type="GeneID" id="9577037"/>
    <dbReference type="KEGG" id="tve:TRV_02312"/>
    <dbReference type="HOGENOM" id="CLU_009043_1_0_1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="376"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="658" mass="73731" checksum="201EBE2886262C4D" modified="2010-05-18" version="1">MAAPATLFMTPAETQRIQKTAQEHAQERQGKAGQPREAHDTKALVQQAVGKSVMDDFAAAALDMGTLPKDKSEDTVPAYAVGCQYLPCTASLADLEPIKLSDLRMETHHRGRVLSLRRISPVVKLRSSSWTIVQEAGSDDADRLELSLHNTRNGEDMLDSASAFFIKEPYYTLNTNHESVIRVDHPSDMIITTYSDNPSSWRNNTGDKELASTASKSATQCKEEGNAALGKKAYWRAHACYSDGLKLIPKDDNSTLRKDIYRNRSYVNLLLQRYDEAISDAFASLTHGTEEEQKALDAKAYSRAGSAAYSLGDFEAAKGFFEEQEKLQPDDRLVKINLKRIKLRAQEKESGIYDLQKVASSLSKLQGRADVASYYGFTEIKESPGAGRGLFATRDIEPNETIMYEKAFCVVWSHDPEAMSCLTIDMRDNAKIRVFPSGLHKAIVQKLMNNPSQVERVLALCGEYEGLGNKLLEIDGRPVLDTFQLHDIVQRNAFGPGQQTENEDVTNASTGLWSRASYINHSCVANTKKDFIGDLIILRATRRILAGEELTHCYDENSDYSTRVATIERTWGFKCQCKLCAAEEADGEELRQKRANLEKEVGNFMKKESAQQPKKIAIIRAKRLRQNILDTYDQNKYKDLPRKALFGIEQWLQAARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T2</accession>
    <name>D4D5T2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023353.1">
        <property type="nucleotide sequence ID" value="XM_003023307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T2"/>
    <dbReference type="GeneID" id="9583373"/>
    <dbReference type="KEGG" id="tve:TRV_02455"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37956" checksum="D35250F592753E81" modified="2010-05-18" version="1">MNSIPIGLQKKPRVLSLGTIKHLGEDFIAEFQREFDLSVLDTCPRSQLKSRLEDDIKEHGPVDAFIIGPNSIPYYPFDEEVLSPLVPSCKIIASLTSGFNMFAVEWIAKQGMWLTNTLDAVAEPTADMALFLLLAVFRNTTNAERSAREGTWRNNLNPTHDPSGCTLGIVGLGTIGKYLAKKAAVFNLKVIYHNRTQLPGDVESEYGVTYYASLHEMLAASDAVSICCPLTEQTRGLIGPKEFAVMKDGAYLINTARGPIVDEKSLIEALESEKIARAGLDVFNEEPDFNPYFKTSDKVIIQPHLAGLTDAAVRRAGQESFKNVRALFRTGRPISPVVDIKPNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D637</accession>
    <name>D4D637_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000132">
        <property type="protein sequence ID" value="EFE42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023305.1">
        <property type="nucleotide sequence ID" value="XM_003023259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D637"/>
    <dbReference type="GeneID" id="9583322"/>
    <dbReference type="KEGG" id="tve:TRV_02560"/>
    <dbReference type="HOGENOM" id="CLU_039755_3_0_1"/>
    <dbReference type="OrthoDB" id="4172088at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="408" mass="45435" checksum="3DF089D638CDA37E" modified="2010-05-18" version="1">MDEHCPGYGFDDEERVRLIAKMRELLQTVSTSSALWACLWLSDLHRLERLVADASSPSNRTLDALSIMSFDSITKQWLQLPGSGIETSSKKPSPATKPGSLGREAAMNRIALTASSTGAAADEPAVQAPQTPPRAAKRPRLQSRSPSPLGSGSTASRSQSAARDCRERDGDRCTITKAYHPIDVAHIYSYSMRNTTERGPGHNFWNLLSYFWTDEHVNSWYESVFPRGTEVVENLLCLAPQMHRYHGSSLFALKPIHISDDKKRLLAKFYWLTSHQKSDSVDISTVPTLPSNLTGRGDMHKAWNIVTEKKIISGDEIVFETSDPENLPLPDWNLLDMQWTLQRVAALTGAADMLLDDSEDDDSDDGGIEWDEGPTVYSQEVWEEDRAGLRNALFNPPPIPQTKIMGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D1</accession>
    <name>D4D7D1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022851.1">
        <property type="nucleotide sequence ID" value="XM_003022805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D1"/>
    <dbReference type="GeneID" id="9581575"/>
    <dbReference type="KEGG" id="tve:TRV_03013"/>
    <dbReference type="HOGENOM" id="CLU_069884_0_0_1"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="59"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="34540" checksum="AD199B6AA3FB9E8C" modified="2010-05-18" version="1">MTSSAAHDLPLRGDYNNQQASKKTRRKKKKKKKEEEEEEEARSKMDDPRTGQPFPPSTIQRVLYSCSAVHVYALPPLTSMKGYLAASWTSNSASEIFAGRLRVLESAVPVKVPPASRPATALRTPNRPLALPEEEPDLQPEAKEEEEEEEQRLQVDILLEEAGGAHELFAAAPYVDAGVVEQTLDSSRFFALRVEGEGKKAVLGLGFEERSEAFDFSVALQEARKILSLSASVASSAASGGDAGRDLSLRPGESISVSAQPKTASEEAREDEEEEDREEEKQEKQKKALFSLPPPPPASSSSSRRRPPASSSSPAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D2</accession>
    <name>D4D7D2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022852.1">
        <property type="nucleotide sequence ID" value="XM_003022806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D2"/>
    <dbReference type="GeneID" id="9581576"/>
    <dbReference type="KEGG" id="tve:TRV_03014"/>
    <dbReference type="HOGENOM" id="CLU_016218_0_1_1"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="346" mass="37376" checksum="10CD46384654D9F5" modified="2010-05-18" version="1">MAGYEYDYVLTEDSIVETYHKLLRTDPDLTMPIAAIEALVLLLTHSPSSTISETLDLLNKHTEHLKRSIPNPIGLSAGTDLFQRYLISTLQRPGKLGPAGDFDAIRAHLLSNGRLFIQRAKESRDKIAAFATGFVRDGSTVMTNGGSRAVGAMLRKAAGEEVRFRVIYVLPNGHSDEEATTAAGTVPEGMETVAVLRSKGVPVATVPESAVAYSMGMVDTVIVGAEGVVENGGIISRMGTYQMGLLAKAMGKPFYVVAESHKFVRLFPLGQYDLPVDQRVIEFTTTTTTTTESSSNSGSSTSPKDRRRTAPDIVDYTPPHLITALITEAGVLTPSAVSEELIKIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7F9</accession>
    <name>D4D7F9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022817.1">
        <property type="nucleotide sequence ID" value="XM_003022771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7F9"/>
    <dbReference type="GeneID" id="9581541"/>
    <dbReference type="KEGG" id="tve:TRV_03041"/>
    <dbReference type="HOGENOM" id="CLU_003573_1_1_1"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121415" checksum="7F6A0C6E86F29334" modified="2010-05-18" version="1">MPGIVMDDPSVHGVWRTVGTVNGDNAASDNGAFQNTDINSHANGQANGIKSQSNDIITAPELPPPEITHITQGFFPLAKGINRVVVQCWNDLLHLLSELGDAPPNHQGGSSSSNASSAKKSQILEFAQAKRAEFIKLLVLSQWGRQAVDVGRLIDLQFFIRQRYDLYNHAIFLAGNIKRDLFKAQMGNPDLETASEALSTGAVSALPALPFLPPGKLSPKDTLRTLRKINKLISIRLITHDSIPEYATYRIHDGRVTFTIPNEIELDLSIAQETRNSQFFFVDLRFIFSPSSALSRGPVRDNLERTINTSLMKSGIVGCCDLLHNLVLTQKIMTCFRQAVELARSHWGNNLRIELLHRTLVIQYWTNRPGPKSWIEIGTRRNKSQHRGRANQPDIPRLYVRWIRDNKEVSVESTHFENKIISVETILRRTISRHIHDIFFEVYTKLTASKLYGQGVLFLGLNTSAMEPGNCYLDIQLTRRKTMRLAIEPVGGIVALRTVPLSLSRHDVEPDPNKALSVGTYERICRLRCLVAMEEAESHGRVVGWKLIAPANVDMQSLRKVLPVNEIRNISLFQHGDWDPNWLVAFTSSIERDDWWVIQLRDQASATESQPQCPGDGRLIQLQQAHAITGQCGYASNKHRYRSFAKLANSISGMVVAHSNADCLNKLKLCHFPKIEDQVLGVDNEVPSTSVCYKASDLPHQLRVASPLSNKGKTIIKDTIRLSYKGINHRTREAIVVATGFFAVPVSHLGMAILASDSNLSFKPRSRKFAIRFLTRTGVPIIEQLFSWLQRLTNTILALGFIHRKKFVVTSMSSSKISFTYPSSNGSLRASISFQYIDTPPPLLLPDTQQAKTKGDKRPLARLRMSLDLHGKNPHRRIMESLTAILNDPSAGLGFTLELLTLTLPLLEAVETILAESRDRSRAVVRIAARSAKMFHISYPFLQYRFHLTMKQRRQRISWLLRNGTIPSVRMSQVALESELTNKILKVNGDGWRGLGDGAMAEADNAVSLIMVLDNIIKTHVAQQRTQTAANGAGRAMMLDGNQSNSVPASLSNSSGTSQPAMTATSTTGVVSPNNESDASKQANNGSVITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D893</accession>
    <name>D4D893_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022530.1">
        <property type="nucleotide sequence ID" value="XM_003022484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D893"/>
    <dbReference type="GeneID" id="9581107"/>
    <dbReference type="KEGG" id="tve:TRV_03329"/>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="330" mass="35431" checksum="22ECB558521A810E" modified="2010-05-18" version="1">MAQEHPATGTTGENGVTKDFTVKAGLAQMLKGGVIMDVINAEQNTSRRRISMLTRHFDLQARIAEEAGASAVMALERVPADIRAEGGVSRMSDPGMIKEIMAAVTIPVMAKARIGHFVECQILEAVGVDYIDESEVLTPADHVYHVTKHSFNVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRQVNTEIARARSILQSAQDPEIELRAFARELGAPYELLRETAEKGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPRKRAKAIVQAVTHFKDAKKLAELSEGLGEAMVGISVRDMSEKEKLSGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8E9</accession>
    <name>D4D8E9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000176">
        <property type="protein sequence ID" value="EFE41871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022489.1">
        <property type="nucleotide sequence ID" value="XM_003022443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8E9"/>
    <dbReference type="GeneID" id="9581066"/>
    <dbReference type="KEGG" id="tve:TRV_03385"/>
    <dbReference type="HOGENOM" id="CLU_060372_0_1_1"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="265" mass="30124" checksum="F2A8A7370B6391A9" modified="2010-05-18" version="1">MDFQIISDLHLETHPAYDFVIERTAPYLALLGDIGHLEHDQFFPFIEELLSRFEIVFLLFGNHEPQSYTMDAARRKVMAFQDRLSSHSSPCPPSTSTGRFVFLSQTRFDVSDSLTVLGCTLYSHILPEQDQAVAARMSDFKMITDWTTKTHNHAHDADLAWLNAQVREIEQREPHRRIAIFSHHAPSLDPRAVDPKYAGSSVTSGFATELRDQPCWTSSAVTTWAFGHTHYNCDFQLGGVRVIANQKGYYASPRDTFVPGRIYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W1</accession>
    <name>D4D8W1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP dependent RNA helicase (Dob1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022338.1">
        <property type="nucleotide sequence ID" value="XM_003022292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8W1"/>
    <dbReference type="GeneID" id="9580885"/>
    <dbReference type="KEGG" id="tve:TRV_03549"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="162"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="399"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115528" checksum="9A2F6C842A150DEE" modified="2010-05-18" version="1">MDDLFDVFEDKPGLKDATNEPPRPRKARNKKRRANGDIKSENVATANGTESPEPVEPAGEKSDAAEAEVQDDQPDIKRLRVDQEPEPVVADTFETEQSREVAASAGFQGQQDGKAVVLSHQVRHQVALPAGYDYIPISQHKPPEKPARVWPFTLDPFQQVSIASIEREESVLVSAHTSAGKTVVAEYAIAQCLKNNQRVIYTSPIKALSNQKYREFAAEFGDVGLMTGDVTINPTATCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKTRGVVWEETIILLPDKVRYVFLSATIPNAMQFAEWVTKMHNQPCHVVYTDFRPTPLQHYLFPAGAEGIHLVVDEKGVFREENFQKAMSSIADRQGADPADAMAKRKGKGKDKKTNKGGDKNGPSDIYKIVKMIMMKNYHPVIVFSFSKRECEAFALQMSKLAFNDNSEKEMVSKVFNSAIEILSEEDRDLPQIQHILPLLRRGIGVHHSGLLPILKETIEILFQEGLIKVLFATETFSIGLNMPAKTVVFTSVRKFDGVSSRWITSSEFVQMSGRAGRRGLDDRGLVIMMVDEEMDPPVAKDIVRGEQDKLNSAFHLGYNMILNLLRVEGISPEFMLERCFYQFQNTASVSGLEKELAELESSRDAMTIEDEGTIREYYDLRQKIDTYNSDMRAVITHPNYCVSFLKPGRLIHIKYQDYDFGWSVVVNCQARKPPKNAPREEYEPRESYIVDVLLPVSEDSFLKSKGVQPLPPGVKPANKGEPSKLEVVPVLLNCIHSISMVKIKMPSNLKPEESRKAVKKQIMQIQQRFPDGLALLDPIENMNITDDEFKRLLRKIEVLESRLISNPLHNSPRLPELYDQYAAKVELVKKIKETKKKITEAMSIIQMDELKCRKRVLRRFQFINEDEVVQLKARVACEISSGDELMLSELLFNGFFNNLTPEQCAAALSVFVFEENAKDTPAITNEELAKPLRDIQAQARIIAKVSQESKLPVNEDEYVKSFRWELMEVMFEWAKGKSFADIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y5</accession>
    <name>D4D8Y5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022362.1">
        <property type="nucleotide sequence ID" value="XM_003022316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y5"/>
    <dbReference type="GeneID" id="9580909"/>
    <dbReference type="KEGG" id="tve:TRV_03573"/>
    <dbReference type="HOGENOM" id="CLU_139861_0_0_1"/>
    <dbReference type="OrthoDB" id="4201344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="18529" checksum="587D50194FF3096D" modified="2010-05-18" version="1">MAWASIVHEATRRPPSPPPGHVYHHTCFVYSPDDVSTSSPPIIAYISRNGDIKMRDIDLDWTNNPRIVIKELVTSKRMSRHDFEDILRLASQENSREDMKCSNACRHLREFQPGFDLLQWFGRQMAEIYLVALRSGLEDDLWEPDPPEYNPTSFPSCIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B2</accession>
    <name>D4D9B2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022179.1">
        <property type="nucleotide sequence ID" value="XM_003022133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B2"/>
    <dbReference type="GeneID" id="9579073"/>
    <dbReference type="KEGG" id="tve:TRV_03703"/>
    <dbReference type="HOGENOM" id="CLU_044876_5_0_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="305" mass="34480" checksum="AAA95F3985DC6C8F" modified="2010-05-18" version="1">MKVAIAGYGDLTRYICEEFVQAGHELVILTRSFKPQIESPGISQAITDYTISSLKAPLADCEVLISTIGDMSNAYTSVHHTLIQACQESPKCKRFIPAEFAVNIETYPDEPGFYYAIHEPVRETLRNQTNLEWTLVCIGWLADYFVPSKNRYIKDIDECHPINWKANKAVIPGTGNEPVDFTWARDVAKGLASLIQAPTGSWEPYTFMSGERSCWNDMAALIKEKYRPDMPIEHVSLHATANMIKAAKDEDTLILADYYLLSISQACAIPQDKAKAHKEKFFPHIHFRNLREGLSQFDEKPNSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9C8</accession>
    <name>D4D9C8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mis12-Mtw1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000190">
        <property type="protein sequence ID" value="EFE41541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022159.1">
        <property type="nucleotide sequence ID" value="XM_003022113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9C8"/>
    <dbReference type="GeneID" id="9579050"/>
    <dbReference type="KEGG" id="tve:TRV_03719"/>
    <dbReference type="HOGENOM" id="CLU_021697_0_0_1"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="592" mass="64611" checksum="7B2E89B57ADD4A38" modified="2010-05-18" version="1">MTAVLVATCTTTTGLEHHLGNISCRPGGAPIQNRGVIGDQEKLLLRIRADTQQAQQDLLTGSPGLAMSQTRGRGKTSVTAKLPSSAAKENVVGRNGISGLAAKRKAIDYDEDVEGFQFTRAGNVKKPKQTNGVLLNGASDGSSTPELSSAASVLRQQKKKPVTSREQNDIIEPSSESIDNRTMKPKSKRPVQDSTEPMNQKQSKSLKKIQTPDPGPIHVAKKRKPGSSKDSAPKIPPKDNEEAIQSTPEEIRNASTKIALPFADTPVIQRNKDMRKEKSRKGQRRSSLSLRGRRASSLIDSGVSNASEGLPEPRRMRQLLTWCATRALGEKPTGSRSEDESARLAARVIQEELLKDFGDRSDLTDWFSRPETTTPAVVIKKPNPKNIQNADKIKELEEHIRRLQAERQSLAALIRPPSVPSIGTKSDIIKHPTSKQDDRPEPLRRDPSAVNQSLLDPTQASILNILGHSESRPKEASSKTANSSPEIDTSILSILERLTRLSTSLTPTLDSFAAGIHNIEMFRQSADSLSSHILRICAQRLEERDGLQGKNADVLTLPGGKEDGKNSLQGTVVGGREDLSDILRALSRLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9I6</accession>
    <name>D4D9I6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000194">
        <property type="protein sequence ID" value="EFE41494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022112.1">
        <property type="nucleotide sequence ID" value="XM_003022066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9I6"/>
    <dbReference type="GeneID" id="9578996"/>
    <dbReference type="KEGG" id="tve:TRV_03779"/>
    <dbReference type="HOGENOM" id="CLU_021319_1_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="523" mass="57566" checksum="88F97B9B8BAED0C3" modified="2010-05-18" version="1" fragment="single">ELDSVDTSNQTAEATRPSQIVCRAIESGHDYDLIKELLTNYSQSGGGDTISPEEKLDILLSVIACSRTDLVDLVIENGADPNGRVHNSEIPLIASAILNRNSTSVSIVKLLLAAGADPNSIPKSLWEHGVFTYQSPEPDDDDELMDSGLKALKDTLEESVNVSIRHCLFQATRTLPPLPASVEMYLLPFIKRITRAEHLLIGQRTAIKWVRMFIIMKFMTRTNSPLVMAFVGPAGHGKSSLAKELGTFIPISSLQRVDPDPGEGEDEELSNDTSPTNAPGELEVIFVDKGDKAEYQRLLSFLEGEDAFDPWLIMSIGYYLSEGEKVIIDRSNTLCIIAASSGEDKVMEYYDLNSRELEVELADTANWESRLHRELELFVANDLEKEIGTSLAGHVSCYIPFTPFSKTEAAVLAHSYLLKATDSLAEFHDSLHHAKLGESDNVTFILDAQVEACDNLATTVYVIKLGARSIEQGVFKAVQSQMVQHYLKSDLLKENRGQGENAGNAGDRCVTITVGEDFAIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA54</accession>
    <name>D4DA54_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LACTB2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021909.1">
        <property type="nucleotide sequence ID" value="XM_003021863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA54"/>
    <dbReference type="GeneID" id="9578792"/>
    <dbReference type="KEGG" id="tve:TRV_03998"/>
    <dbReference type="HOGENOM" id="CLU_1768268_0_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LACTB2 winged helix" evidence="2">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="159" mass="17581" checksum="F1604585504F6D85" modified="2010-05-18" version="1">MEEEEAMFTGDTDLPRLHEDVLGQGTAVFEELKTYMASLEKMGDKASVSARGYPGHGPVIENCKSKIAEYIRHRQQREEEILRVLKYGSLDSSQPGDTKPSGWTPIELVKVIYAAVPESLHLPASHGVIQVLNKLEHEGKVTSDEQTGRWSCSSKTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA71</accession>
    <name>D4DA71_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyubiquitin binding protein (Doa1/Ufd3)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021840.1">
        <property type="nucleotide sequence ID" value="XM_003021794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA71"/>
    <dbReference type="GeneID" id="9578720"/>
    <dbReference type="KEGG" id="tve:TRV_04015"/>
    <dbReference type="HOGENOM" id="CLU_011791_2_0_1"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000377">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="483"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="82364" checksum="44087A5F16542556" modified="2010-05-18" version="1">MPDFKISALLEGHSDDVRAVAFPTTSTVLTSSRDATVRMWTVVSSPPPKFDDKITVHGSAFINSLAYCPPTGDYPEGLIFSAGQDTIIEARQPGKPADDNAERLLLGHTGNVCALAVSPDRKWLASGSWDSTGRLWEIGKWSKEVVLDGHGGSVWAVLAYDKDTVITGCADKLIRVFNTSGKLLNTFRGCGDVVRALCKVPDGHGSGAQIASAGNDGIIRLWTIQGKQVGQLHGHESFIYSLDSLPSGELVSSGEDRTVRIWNATSCIQTITHPAISVWSVAACAESGDIISGASDRIARIFSRDKGRQADEATTQIFENAVKESSIPQEQVGKVNKEKLPGPEFLKQRSGTKDGQVQMIREDDGSVTAHTWSSASSQWVPVGTVVDSVGSSGRKVEYMGQDYDYVFDVDIEDGKPPLKLPYNLSQNPYDVAKKFIANNELPISYLEQVANFITTNTKGAVVGPPQTSESTYQQPSIPDSRPKVLPQASYLSIKSANLKAIQKKISEINTQLVSSGSKDLSLAPSEMEDISALCSQLEQPSSLSKSPVVEATLPLLVKVSTSWPAANRLPGLDLLRLLAAAGDAAATWDQGEGNLVSVIISSGVFGAPLSPNNTMLAIRMLANFFETGPGRALVAGCFEEVTNKIGSVMSDSVAAGNRNVTIAAATLYINLAVYFTSKENVDSPEASEHGLVLIDQLTKVLRNEKDSEAVYRGLVALGTLVVGLDHEIQTAAKEIYDLDQTLTRVLDAGFGREPRVKGVISEIRDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA77</accession>
    <name>D4DA77_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021846.1">
        <property type="nucleotide sequence ID" value="XM_003021800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA77"/>
    <dbReference type="GeneID" id="9578728"/>
    <dbReference type="KEGG" id="tve:TRV_04023"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_3_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54806" checksum="933FC1FCE87D1737" modified="2010-05-18" version="1">MGCGMSTEDKERKARNEEIENQLKRDKLMQRNEIKMLLLAADQSHNSHTTGAGESGKSTILKQMKLIHEGSYSRDERESFKEIIFSNTVQSMRVILEAMESLELPLDDQRAEYHVHTIFMQPAQIEGDSLPPEVGAAIEALWKDAGVQECFKRSREYQLNDSARYYFDSIGRIAAPDYLPNDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFINTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYSAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNGKLSLLNPLDEALSNNTSRHHHTRESPTLRSHIMHLSLFFKKKKKKSQLPDLYPGRCLSLSLVLRVFDIPIINLLKFPQQPTRYVSRLFIFSFPRPSNLLCVALRSFTLLFLFLPSNPRRLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAJ8</accession>
    <name>D4DAJ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000209">
        <property type="protein sequence ID" value="EFE41129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021747.1">
        <property type="nucleotide sequence ID" value="XM_003021701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAJ8"/>
    <dbReference type="GeneID" id="9578627"/>
    <dbReference type="KEGG" id="tve:TRV_04145"/>
    <dbReference type="HOGENOM" id="CLU_040048_0_0_1"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="45662" checksum="EA78D2E7BEFE42A0" modified="2010-05-18" version="1">MEAQNLTFCLLFGLSSSARCYFLSLLLFIFEFITSVINIVYIIPREKIHVVIMTVNASDEYLLRKFATRELDEFRINFRNPKFFTPAYLPHKLSIGILDRLPLELLHEILYRLDLKSLSALLCVSWGGNVAVNDLPQYHAIVKHVPYTLEAIRRAGLQSEYTVQKLYKTLRTRDCPECGEFGGYMFLLTGERCCVACLDMNQNFWALPIDNMEQELCFTFYGRTDLVVMNALPARPYSDRVEPAEGLRLISLREAVKVVKRNGTLLVFDFITCLGRECGSPAPLPMVQSCYCKFGPERQNDVVPEQPRYESRIPPTGYPVWLSEPSNSYGIMSSIRLPYLLPDGTLDWGFFCDRCMSMAYYPYLIPESEFLKHARVCERIREYVESNCGVPGPSIEKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB32</accession>
    <name>UTP25_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName>U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>U three protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UTP25</name>
        <name type="ORF">TRV_04331</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021484.1">
        <property type="nucleotide sequence ID" value="XM_003021438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB32"/>
    <dbReference type="GeneID" id="9578465"/>
    <dbReference type="KEGG" id="tve:TRV_04331"/>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000408142" description="U3 small nucleolar RNA-associated protein 25">
        <location>
            <begin position="1"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="714" mass="80537" checksum="F61A8E87B7298BD8" modified="2010-05-18" version="1">MAIQHKKGGGHRGRGSKTGRSRGRKFETSRLKDVREDESSGGEEDVDGQPTEDMNDSEGTDVSSESGLDEPPKENSYSTLLKLLNTDAKSNEPARKKRKIKANEPDANPVEVSIPTADDTEQMDEVADTEASASEDENMDDEDIPDEDYAEDIGTDGRNDMFELHFGNPDETELSHKIQACSKAWKSTKADLIDGLYSVVSMPDAGGISSASLPTTPSPADLKLKQKLARNAVSFDRLNSCLTPYIFGYHDTLFCSRTTQNSAKLRDLYCLHALNHVLKTRDRVIKNSAILSRENNGDVELRDQGFTRPKVLIILPTRQACVRVINSFTKIYPMEQQENKKRFMDSFSAADSDEWAHKPDDFKELFGGNDDDMFRLGFKFTRKSLKFFSKFYSSDIILASPLGLRTAIEKEGGKKNENDFLSSIEMVIVDHADALMMQNWDHVEYIFSNLNLQPKEAHGCDFSRVRQWYLDGHGKFLRQTLVFSAFNTPELNALYNTQMQNVFGKAKIMSKYEGAMLNLRLPISVKQTFSRFDSASPLKDPEARFQYFTRTVLASLARGWTESSPRKKSGGTLIFIPSYLDFVRVRNHFANSSQTENISFGLISEYTSVRDSSRARSHFMNGRHSVLLYTERAHHFRRYNIRGVTNIVMYGLPDNPIFWGDLIEYLGSAAGGTSTPTVRVLFSKWDALKLERIVGTARVRSMLLEKGGDTFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBL0</accession>
    <name>D4DBL0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021355.1">
        <property type="nucleotide sequence ID" value="XM_003021309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBL0"/>
    <dbReference type="GeneID" id="9578261"/>
    <dbReference type="KEGG" id="tve:TRV_04510"/>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="145" mass="16206" checksum="9F81C10E45A1E707" modified="2010-05-18" version="1">MANETVSIDFTQVAKQFVEFYYKTFDENRGNLGSLYRDQSMLTFETTSIQGAVAILEKLTSLPFEKVAHQVATLDAQPSNENGGIMVMVTGALLVWNILILLITHYSRVDDSPAPMNYSQTFQLLPDGAGSYFVFNDVFRLVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBQ2</accession>
    <name>D4DBQ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021346.1">
        <property type="nucleotide sequence ID" value="XM_003021300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBQ2"/>
    <dbReference type="GeneID" id="9578178"/>
    <dbReference type="KEGG" id="tve:TRV_04553"/>
    <dbReference type="HOGENOM" id="CLU_049331_2_0_1"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="37060" checksum="25356DD452C4C7F5" modified="2010-05-18" version="1">MAGRGGAHQDRTLKTSLQAVHASSAPASSQYRGKGSPDPRHMAIALHHARQIQSRKELELQILSHIETLMELPTTPGATVESPSAEDVSTFFSAIACFQPSDYDNLIQERNIDGSCGYTLCPKPRRKDNSKGGYRIVWGSKGSGPGGRGKDMKVVQKEKLEMWCSEECAERAMYIKVQLSEKPASERIGSAGKDFVLLEEARRGDSLRLSAERVDRSAMREVEENLQGLTLQTNDTNPTYGQDHLSRESQDLSMQDAGSSSVNPSSDAGARGLLAPTVVERDTDDSRHPKAPIFQPDSAKGGSVEGFHPRQDTQFRNWPSSNKDGDGDEDMDDFLPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBX6</accession>
    <name>D4DBX6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000234">
        <property type="protein sequence ID" value="EFE40646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021264.1">
        <property type="nucleotide sequence ID" value="XM_003021218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBX6"/>
    <dbReference type="GeneID" id="9578109"/>
    <dbReference type="KEGG" id="tve:TRV_04627"/>
    <dbReference type="HOGENOM" id="CLU_2401273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="93" mass="10875" checksum="46E8E5B02AFEEE54" modified="2010-05-18" version="1">MAGDDRESAGPEEERTPSWTLELQTERASRLLRTKGLREKAKKQQQRKAKKTIPDRLAHTYLQKKKEKTKKQKAKEEEEADWPLFQALGVNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBY3</accession>
    <name>D4DBY3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021203.1">
        <property type="nucleotide sequence ID" value="XM_003021157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBY3"/>
    <dbReference type="GeneID" id="9578048"/>
    <dbReference type="KEGG" id="tve:TRV_04635"/>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="41123" checksum="EDB2151E159EB5A6" modified="2010-05-18" version="1">MPELAEVARIVNYIKKHLVGHTIAKVVANHDDLLFGKVGTSADEFKKHMHGKTVIGAGQQGKYFWMIMSSPPHPVMHFGMTGWLKIRSENTYYRSNGKDENFEADVWPPKFWKFLLETDNEPKTEAAFVDARRLGRVRLVDCPGDEIRKYTPLKENGPDPVIDKAILTEDWLKALVRRKKVPIKALLLDQANISGLGNWMGDTLRDSQIKELHSSINYVCSVSVDLKGESSDFPTDWLFHHRWNKGKKGAAGKLPSGEPIVFVTVGGRTSAVVPSVQKKGGEDDEEETDTKPKKAAGKAKATPKVKAEEKDGADASTPATPSKKRKQPAAKAVKEEDSAATTPASKKSRATKAKAEPEAPKVPLRRGRSAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBZ3</accession>
    <name>D4DBZ3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021213.1">
        <property type="nucleotide sequence ID" value="XM_003021167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBZ3"/>
    <dbReference type="GeneID" id="9578058"/>
    <dbReference type="KEGG" id="tve:TRV_04645"/>
    <dbReference type="HOGENOM" id="CLU_016696_2_0_1"/>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="703" mass="76032" checksum="2E84BD929D5D2560" modified="2010-05-18" version="1">MTDGETPSGSASAPATTTDASAEAQTPTQGEQSATTHANGQSNTTSEGSQHISAVDNSLNQPPATSNPPPQPSVTQTEAPDPVYQLAAANSALDASQSGAVDHAVQLQALQQFNNDQGPFDSNTNSAPHGAPASVPPTAPAPAAPAPVTHITQYYGEIPAGGFSDGFELVTDESAANRMKRDVKRRTKTGCLTCRKRRIKEHNPFVSRCPLWFVAGGNVFFFSLPCWGVFFFAPLVPASAARLASKKTKTPRNPHLNTQIDIATSSTSSLVHVPVLFCARSLLVTISYFRLFILRFIFLCRAHPSLQVAPQNPHQATGLNQAYLPNNSTAHSVSPSINTGSSASPPQDKLDFGTEPEPTPIAAAQPAQTAPAAPAAPVTAPTAQSRSVTPRVAEGHPLIAASTTLPNSEKMEPRQPKMSELLAIGGFALPEVDTNPLSPTKLEEVKMLYRIYAQGMDRLLECNWYDTHGLTQLLGSPRLLSLYSSLLDGFTDPNINDAPVIARMESFESNVIWESLCLCRAARAQEPTNGTDTSDSTDPQLIYAVKRLSLLEALLTGTVLENNPVSRHNYPEDDPAVTTSGLNTQIKNRQLGFWESMGDYLSIPDNEPDASDKRDKALFAARAFLDMIESRDVVYSIAVVRNISKFQPRKFKLPVASDEKDPAAKLYVACRFLEDEVRGKATNQVTRRISQLTVRYWDEPYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCN3</accession>
    <name>D4DCN3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021023.1">
        <property type="nucleotide sequence ID" value="XM_003020977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCN3"/>
    <dbReference type="GeneID" id="9576670"/>
    <dbReference type="KEGG" id="tve:TRV_04888"/>
    <dbReference type="HOGENOM" id="CLU_016392_1_0_1"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="62470" checksum="4CAB3B84181142D6" modified="2010-05-18" version="1">MQLHTLVLPLVASSNTQNVIPPSTRWAAQQLFISLHQCAPKNTGNEEWAKAIRATILSAHRTTDHLFRSIVEHWQSVDSTLPQGTCNRPSHSVVGDFGIGPLELPIWSGIQQGTGRLVGLLELLSSFLKSRSNSTVSIPVGSILDLTCRLGSIAPPSISGEHGASINPEISRDEREALLSAIPPMHAASLGVLQSLLETFGSENPSIARSCLEQTTWMFTSSNAARSVREAAYKCFVASLTIMGPSLTKPDVLSLVPVIQAACSDIVPPKDSAIVTGNTTSGAKGTSTSTGTTNADAFLQNKSIISPGSSYETGPLADSAVKLLLATITYVQIEHIPLSLRAKIDRTSILAGNSDLMLACVLNPIPSTESQRGHPSILPFLARCQPSNTQVEGLLRPRMPVIFTGAGRKGRVEIEDYENGAEIETHGGDSQNPDVRESLAEKFGPRPAPATTESTALLSDAGRNKRRHQDDVDNALPADSPQPDKRPRVQNDIPTSSNALPSGKVAQALDVLSSSLSGSNDQNTLKMNVFPEPEISHPTQDKAQEPSQPPMITKSHETGTAADAESDDEIPRLNIESDTDEEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCP3</accession>
    <name>D4DCP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04898</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021033.1">
        <property type="nucleotide sequence ID" value="XM_003020987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCP3"/>
    <dbReference type="GeneID" id="9576680"/>
    <dbReference type="KEGG" id="tve:TRV_04898"/>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="493" mass="54182" checksum="330FA211D4127DF3" modified="2010-05-18" version="1">MASILRSRAGVRAAVQARCFSSTPRHAAASAFFTNEPAGPTVKTAIPGPKSKEAISQLDRVFDTRSLNMLVDYQKSTGNYIADLDGNVLLDVFAQIASIPVGYNNPALLAATKTTDMASALINRPALGNFPSHNWASILESGLLRVAPKGLDQVFTSTTGSDANETAYKAAFMYYAQRQRGGPDVEFSSEDISSTMVNQAPGSPNYSIMSFTSAFHGRLFGSLSTTRSKAIHKLDIPAFDWPRAPFPQLKYPLDQFAAENAAEEKRCLEEVERLIKEFHNPVTAVVVEPVQSEGGDNHASAAFFQGLREITKRNNVLLIVDEVQTGVGATGKFWAHEHWNLSTPPDIVTFSKKAQAAGYYFGNPALRPNKPYRQFNTWMGDPARALIFRAIIEEIERLDLVRHTAQTGDYLFAGLERLAEKYPGQFNNLRGKGQGTFISWDSPQRDAVLKRGKEVGINIGGCGESAVRLRPMLVFQKHHADILLESLEKIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCQ8</accession>
    <name>D4DCQ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021048.1">
        <property type="nucleotide sequence ID" value="XM_003021002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCQ8"/>
    <dbReference type="GeneID" id="9576695"/>
    <dbReference type="KEGG" id="tve:TRV_04913"/>
    <dbReference type="HOGENOM" id="CLU_487613_0_0_1"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="540" mass="60232" checksum="B80034DAA52D25A8" modified="2010-05-18" version="1">MSNNPPPPSFDRDSSHDLTSFQTIAARIRQLRDIISEMDEDRSFFLHALDRSLQEYNTADSTVDPQAISNPSSEPLPTLSQTLQRHVISQREARRQARQAQQQQQQQQQQQPPPPPPPPPRPPLQRQESLASLASLQRAERQFRQAIASIGAVESTPRQPERAPARSPPMDSMSDHRQSKRRKIDADDSRDTTKGFSYSHYGQVTSVPLEMEVHSCKGGSAEPDRRGNSPDHILVNDGVAYRAQGGFCNIVLKHRGEIPFSLKKLIIKTPKSGCHDETNVREGTVSIAMDPDSRFLRSVASCTADSMPGFPSRRPRRRNEQLSPFTAAAMGNTRRPETSASILRARMLRTRASQQPYQAFDYPFGGIDVEDKSDDESTQLDAARDQLGLSDPEPSNSRDSSPNHDGSDSESSDGISGVAEALAQNLDSRQRQLLEALGVRVPYMQTRPSHRHRALSPTTVFARPAAETGQNQESDTMQPVARFAIEHERAAVQIRFNPPVSARYILIKMWAPYNPGRMDIESIIAHGFAGPRFFPSQEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCU1</accession>
    <name>D4DCU1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020952.1">
        <property type="nucleotide sequence ID" value="XM_003020906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCU1"/>
    <dbReference type="GeneID" id="9577804"/>
    <dbReference type="KEGG" id="tve:TRV_04946"/>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="399" mass="45017" checksum="F59818E2EDBC32AB" modified="2010-05-18" version="1">MSKQARYILLSLPNSISPSHHRDDALEAIRSIVADNGNSFPFTVPEFKIGTLDALVQQADELGKAEALCENVVSKVGDVLSSVLEGDEAQISRMKMVNERPLDQYLQSFSWNKVKYRADKSLAELIDLLQKEINSIDNDVRLKFTQYNGVKSNLASLQRKQTSVMVYVSVLGNLSTKSLASVVDPSLLVQDSEYLETHLIALPSRDVKDFLRAYETLSPMVVPRSSILLASDDEYTLYGVTTFKKHSAEFIHKCRENRWTPREYKYVEDGGEEERKEIDQVAGDAKRLWGEALRLGKTGWGEAVMVWVHILALRMFVETVLRYGLPLDFTSVLIKSTGKNAKKIKDALDSSYSYLGGNAFTRDKKGRVRKDDPNEMQQVGVPDTAAEFTAFVYYEFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCW6</accession>
    <name>D4DCW6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020896.1">
        <property type="nucleotide sequence ID" value="XM_003020850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCW6"/>
    <dbReference type="GeneID" id="9577748"/>
    <dbReference type="KEGG" id="tve:TRV_04972"/>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="749" mass="81580" checksum="F79E13372390FFEF" modified="2010-05-18" version="1">MQFSRFIPRAGTPSLPPYGAHDAPSSADGARGAAPPDAITPYLGLRARLSQVWINKWTILILLVLVRLLIAVGSLDRNMASAEREALSACTSVESMGSAMASMPHYMSMGVNELTASGVEKAVNGLMSMLSLVVTGVEEIVLFVIHVLTSTYLCLITLVVRGSLHVALKIIEDTTEFLNKTLHDIGSGITKGVDGFQKEVNDFIKGINTVTSIFGDDNKIPSLDISGEVNKLNDLKLPSSINDGLDKINSSIPTFDEVQELADTVIRKPFQLVKKLINETVVDYHFDRSLFPVPEREVLDFCTKDDGISNFFDGLRVVISTAQKIFIGVLVVAAIAACIPMAYGEVRRYRRMKERSLLVRKDAHDPMDVVYIISRPYTSAGGLKISSWFRSGRKQVLVRWMVAYVTSPTALFLLSLGIAGLFACLCQYILLQAVKKEVPALTGQVSQFADKVVHSLNNASKQWAIGTNGVIDHTNNDINQKVLGWVNQTTGPVNDTLNAFVEKTSEVLDKAFGGTILHDPIQDVLHCLIGLKIEGIQKALTWVSDHAHVDFPHVREDMFSLGAIQSISKDNATNPDSFLANPGDKTADKISSVVIRVTEAVESGIKTEALISAALISLWFLLLLIAFIRVLTLAWRRDRVRGDGGIDAAYHPPAVGTRAVPNIELNNFHDVPLNSPAIGTGMALGAAPKYSATPNPPGSLYPTAPSNEDDYQAQKLGYAGQRDYEMALQKDMRTSSHGQVEYGTDVKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDL2</accession>
    <name>D4DDL2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">YeeE/YedE family integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020697.1">
        <property type="nucleotide sequence ID" value="XM_003020651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDL2"/>
    <dbReference type="GeneID" id="9577396"/>
    <dbReference type="KEGG" id="tve:TRV_05223"/>
    <dbReference type="HOGENOM" id="CLU_037802_1_1_1"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34705" checksum="EF06B42EDAE65DFB" modified="2010-05-18" version="1">MPFTPINTSLGALLLYQGSYGLLQNNGRVFGISSLLSGCVGNPNTQNVPVILGMVSSIVPVYLLAPSLLPPYATPPATWGAALALAGIGFLVGWGTKNGNGCTSGHMLCGISRISPRSFIATGIFFITALVTANLGIGATVSPPPDGRPAYLPVYPSIDEVAFMFSTVAISQAFNSFLVPALLPRYTNSNVVYSCIAGLQFGLGLLITGMANPEKVLGFFHWFDPSKFDPSLALVMVFGVGPSLLSYLYMKTEYGNEDGMKPPLLADRFSLPTATIADIDWRFVVGCVAFGIGWGLSGVCPGPGLLRSALSPLWGAPWLAGFWLGSLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDR4</accession>
    <name>D4DDR4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05276</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000270">
        <property type="protein sequence ID" value="EFE40009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020627.1">
        <property type="nucleotide sequence ID" value="XM_003020581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDR4"/>
    <dbReference type="GeneID" id="9577326"/>
    <dbReference type="KEGG" id="tve:TRV_05276"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_0_1"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="361" mass="39949" checksum="B1D2EA82BC908C7E" modified="2010-05-18" version="1">MEDSQNELLDEPVPETVGSKGIYVPPSVDHSRLLAGESYSHYSSCPANIIPSVKLSTEEKKAEPTPCVLGIDEAGRGPVLGPMVYSAFYLPIHLHKSLLADEHHFDDSKVLTPEVRSNLMRSLCTQGHPLHDSCGWAVKVMSARDISSGMLRPSMAAVYNLNAQALDATIEIIRGVVETQGIDVKEVYVDTIGKPETHQARLLRVFPGLKITVAKKADSLYPCVSAASVCAKVTRDAALEACYESWLNQREKQRTLETGEDEATTADEILTWGSGYPSDGKCVGWLKKDMNRLFGWGVECRFSWGTSKELLEVKSGLKVDWPAEEDDSTMLVTQYFTSKSETEGPVNDLRDWYGNKQEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDU5</accession>
    <name>D4DDU5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome complex exonuclease Rrp6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020587.1">
        <property type="nucleotide sequence ID" value="XM_003020541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDU5"/>
    <dbReference type="GeneID" id="9577286"/>
    <dbReference type="KEGG" id="tve:TRV_05309"/>
    <dbReference type="HOGENOM" id="CLU_010129_0_1_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="881" mass="97265" checksum="7B8333694B73FEF4" modified="2010-05-18" version="1">MDAEGFPAFQEQTQAALVDAVKTTNRIASGDLAFHRSFDSPTSRSLTEQSNRLLSLTNSLLRIASANNPDSPFNASSSSASADSNSRSGKNKKKKPKTVLRDEDSVEENWKDVVDVIDELLEKADACLDEFTGVIKKYAPAQEAQKKETAGFPRMYSHGSSKIAKPQLQFDVKLDNADDGRAFRPLLKSKPHALVGLEESLGGSIQDPTKPYNHPYEKEIEASTYPARVYEKAEPTMYTPVADSKAIFVETLEDVHAMLSQLKQAKEIAVDLEHHDSHVYHGLVCLMQISTREQDWIVDTLKPWRDQLQVLNEVFADPSIIKVLHGSSMDVIWLQRDLGLYLVGLFDTFHAASALQLPKKSLKFLLHEYVGFDADKQYQTADWRIRPLLAGMLDYARSDTHFLLYIFDRLRNQLLELLPSSSEEKESGPGGGGREAIEYVLERSKECALQRYERPTYDAATGRGSGGWHDMLSNSPVALTREQFAVFRALHEWRDKTARADDESPQTVLSKRALFRLAQEMPEDKFAVLRMGSPVSASLRSRTDEVAGLIREARQQGGATGPEMHELIRRRSPAGHAAASSRRMATAATTATATGRAEEEAAAAAAVVVGRDGDGDGGAVDLSRATGAAGAGAGAGAAALASSTSTCAVGVRTTESRFWGQTGLENCSINCNDDEYNHNDTDIHGYSVSASTQALQLSLPLPNMPVRLVEGEVPRPVEDEGEPSEDESGEDEEEDEGEEEEAKVSQRNEIFTVRQFGAPPRRRDGLRDDTGETAFDKDASEILLDEGSARKKKEKKKQLKQRSSLGKRPRDEGEEAGRPFDYANAESLIHREKQQKNQNQNQKQKQQGNGQRFNPYSKLLEAPSGVKKPRTETAGRSHTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE05</accession>
    <name>D4DE05_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020540.1">
        <property type="nucleotide sequence ID" value="XM_003020494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE05"/>
    <dbReference type="GeneID" id="9577239"/>
    <dbReference type="KEGG" id="tve:TRV_05369"/>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="622" mass="67186" checksum="73169CF75BD9F833" modified="2010-05-18" version="1">MSSSAVSEMEDGGGSAPLLPSQTEGHPQEDTRPTSKKELAGWYCYGWAAEVFVVCAMAAAAAYSYSEHSATAGLMISNRRLTGSFLPLALEQMTRDQGVLVSDKTTPCTSTWKHTNATANATTAASGLKAGPASNQCLVYVLGFEVNTASFAMYTFSVSVLIQSLIIISISAAADHGAYRKTFLLIFAIVGSIAMMLFFPLSSRLYMLAAFLAVVANTGFGGSFVLLNSFLPLLVRNHPSIRGYKADAPTYSDSSPEVHGDLSASTEQHSSQGNTTHSAPAAPSVSAALELSSKISSNGIGIGYTAAVLVQICCILLVLATNSTTFSLRLVLFLIGLWWFIFTIPAGLWLRPRPGPPLPEHVTRKDSNWPWVDYVLFAWKSLGRTAMRARRLKDVVLFLAAWFLLSDGIATVSGTAVLFAKTQLKMELAALGMINVITMISGVCGAFYWSYVSRLMGLRPSQTIIACICIFEIIPLYGLLGFFPPIRRLGVLGLQQPWEMYPLGAIYGLVIGGLSSYCRSFFGELIPHGFEASFYALYAITDKGSSFFGPAIVGAITDRYGEIRPAFFFLALLIIIPLPLMMLVDAERGKRDADLLVKELEGSPDSDVYEGQAHGTAAERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE46</accession>
    <name>D4DE46_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020516.1">
        <property type="nucleotide sequence ID" value="XM_003020470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE46"/>
    <dbReference type="GeneID" id="9584242"/>
    <dbReference type="KEGG" id="tve:TRV_05410"/>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="12">
        <location>
            <begin position="410"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="841" mass="91615" checksum="18A28A89A8F748F9" modified="2010-05-18" version="1">MALPSMVSITTDFISVGGNRNPAAADWHHGSGLLAFGANNNIAVWNPLDKNGAGVYTLLVGHTDRVNAVKFYTSPTNGSILLLTGGSDHTIRIWKPDTSSPPKFSQAAVVEGYHEGSLNCIEVACGSNTFVSGAADGAVKVWSITEESDEIKCQLLQSISLKPRYFPLAMALKLIPRQNSGAKSDGMVLAVGGTRAAVQIYSAQDTNDLKFELSTTLTGHESWIRSLAFSPVKDSPTGEDRPTNSQDFLLASCSQDKYIRLWKVSLGEGTTSDTPKNVEDQLLAGVEQATLTPKAHNFDLNGAKYSITFEALLFGHEDWVYTVAWHPNPLRQQLLSASADNSLVIWEQDPVTGVWFSLSRMGEISSLKGSTTATGSAGGFWVGLWSPCGDVVVCLGRTGSWRSWRHDTAADAWLPIPGITGHVRAVCDIAWETNGGYLLSTSGDQTTRLYAEWKKGNHHSWHEFSRPQIHGYDLNCLAPLGPSRFVSGADEKLLRVFNETRAVANLLTRLSGLANPKSDEEMPDAASIPVLGLSNKAMDEEVGDDEGANEAGDQGEQQTVQPEVYNLEFDHPPLEDHLARHTLWPEHEKLYGHGYEISAVTASHDLSVIATACKASSIDHAVIRLYDTSTWNEVRPPLTAHSLTITSLRFSADDKYLLSVGRDRQWAVFERDSVNKLLFKLLASNPKGHSRMILSASWAPHPTATVFATGGRDKSVKIWLKEDDTFTAKTTITFSYPITAVDFLPISVHDGLYIAIGDDSGRIFVGKVQAESLEAGEMLMIPQTECPSKSITQIAWRPVKGLVEVHGEDVTATGRKPGYQLAVASEDSSIRLYNIDSLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEB7</accession>
    <name>D4DEB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_05484</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020425.1">
        <property type="nucleotide sequence ID" value="XM_003020379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEB7"/>
    <dbReference type="GeneID" id="9584164"/>
    <dbReference type="KEGG" id="tve:TRV_05484"/>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="744" mass="85153" checksum="A73EE5A3D31D22FC" modified="2010-05-18" version="1">MAADDRAFASGTSPNTEVRRRNVPGAEKSSANVPIPSIEVDGKKLKEKSPSFCEILDDLEVFIAPLIFTALACFTRLWRIGLSDIVTWDEAHFGKFGSYYIKREFYFDVHPPLGKMLIGLSGFLAGYNGSFEFKSGEKYPPEVNYTFMRIFNAFFGIVCIPLAYYTARELNFRRPAVWLITLMVLCENSYATISRFILLDSMLLCFTFTTTLCWARFHRLRHESFSPEWYLWLILTGLSIGCVCSVKWVGLFCTALVGLYTAEDLWNKFGDLKMPKTVLAHHLGARVFGLIIVPFLVYMFSFYIHFLVLENSGTGDAQMSSLFQANLRGTNVGKDSPLEVAIGSKITLKNMGYGGGLLHSHVQTYPEGSGQQQITCYHHKDSNNDWFIYPNRTQPDYNPEGPISFIGDGDVIRLIHAQTGRNLHSHTVAAPVTKAQYEVSAYGNTTVGDAKDHWTIEVVKDVASRDRSKIRTLTTALRLRHTVLGCYLRAGGVSLPQWGFKQIETTCTKENRPWDVYTHWNIESHVNERLPPSQPGTYKSPFLKDFIHLNVAMMTSNNALVPDPDKQDDLASKFWQWPILNVGLRMCSWDDNIVKYFLLGNPFVYWGSTLSLGVFSLLVLWYLLRWQRGYDELSMADIDHIHYSGIYPIVGWFLHYLPFMIMARVTYVHHYYPALYFAILTMAFCIDWFTQKLNRKVEWAIYSVLYVVIIGLFVIFKDIVFGMEGSNQQWKSLNWLSSWKIANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEJ2</accession>
    <name>D4DEJ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000297">
        <property type="protein sequence ID" value="EFE39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020348.1">
        <property type="nucleotide sequence ID" value="XM_003020302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEJ2"/>
    <dbReference type="GeneID" id="9584088"/>
    <dbReference type="KEGG" id="tve:TRV_05559"/>
    <dbReference type="HOGENOM" id="CLU_056221_3_0_1"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="314" mass="35123" checksum="C74FAB5C575C846F" modified="2010-05-18" version="1">MGSYDFTSSHYYGESSHNNHQLDGDKYGSKSNTHLIPPFSIHVDKTLQELDCKIKLQRKQKFREPTMPLFNTNFAGFSLTVSTLMRNPSLLIPHLTIPTFLQLPEDLSYHLIDSVAPEAAGARPPTIRALVIDKDNTLTPPHKTTFPTEYYDKLKQLRTSESSPFNMHTNPDGILIVSNTAGSNPRSKRYEEDARKLEEYLGKLNIKVFRSPAGASAVKKPLSYAAVLEYLKGNGVVNRADEVAVVGDRVGTDVLMASLMGSWSIWTRDGVTQDMKGREGKNYRGTLAGVERYLVRKLQRSGVVATLPKSWQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEN5</accession>
    <name>D4DEN5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000303">
        <property type="protein sequence ID" value="EFE39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020306.1">
        <property type="nucleotide sequence ID" value="XM_003020260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEN5"/>
    <dbReference type="GeneID" id="9584045"/>
    <dbReference type="KEGG" id="tve:TRV_05604"/>
    <dbReference type="HOGENOM" id="CLU_2352429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="97" mass="11564" checksum="E413753E4AB11AA0" modified="2010-05-18" version="1" fragment="single">GRPEVEKVASISCSRVGLELVWRGRAGRRSFSRRETLRAGQVLVGWLVVVMARVLQEPCSRDNARRDEEEEEEEERRRREKKESERWKRIREQEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF86</accession>
    <name>D4DF86_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020059.1">
        <property type="nucleotide sequence ID" value="XM_003020013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF86"/>
    <dbReference type="GeneID" id="9583823"/>
    <dbReference type="KEGG" id="tve:TRV_05832"/>
    <dbReference type="HOGENOM" id="CLU_058490_3_1_1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="289" mass="32623" checksum="E09B5167A61426F6" modified="2010-05-18" version="1">MAALSRTREATQQCIATSKLLIGLPEGTPIVKYTNMKKLKNIIDTQSLDCSADISKSPFLIVTCVDDSFFKALDKAYPDSGPRITYNFEEGGPTVILEVMRNRVNGLATGRLHLEVVLCLEKMGLQYELIAMNESEIKNLNETWRKQPGLSFALADHIHWPVLVIETGMSEGQQKLAIDAQGWLEAQGSDTKAVITINIDKHSPHITFQRWEHEDTRHTTRSRHPHGSVVQTVEVFHKGVTTRATGELIIPFEKVFGRVRHGRKEADIIITKNQLIRLGQLVWAEQRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFE9</accession>
    <name>D4DFE9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP binding protein (Bud4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000337">
        <property type="protein sequence ID" value="EFE39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020035.1">
        <property type="nucleotide sequence ID" value="XM_003019989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583803"/>
    <dbReference type="KEGG" id="tve:TRV_05896"/>
    <dbReference type="HOGENOM" id="CLU_002541_1_0_1"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1344" mass="148822" checksum="057B84F50C90FFF3" modified="2010-05-18" version="1">MRASRVKNSSMFAREHKQEYDPTHIQVLERPLASGRPLSRQFQNSQDGTSQIDARRQLPSQTAGFKNSGEGAGTPQTTAKSGDEDASSPIKSPTSQSPGKSSLSKASRFGRGSAAFDPRREIWSDDADESRVSMTSEGYSYHRQTKSVTFDAAPPQVNEYEMTTPVPSSVASSSREGSFEDASNEDSFDQSYSMEIEDSFDASLEDTDKTPVVLPDEWRYMSPDSANDETVGSDGDPFNDDFGSPGPDIRPSSRDSTLFKNRIESLDSNGERRPLPPLPPSQSSPQTSRSSPSPGLNAAFERGSSAQRDMPQPLRPASCSKSDIASPSRNSLSLEDRLKLMMSGEHSYQSDAETQRERRMRRAGAKERSVERDLDHSQKSEGNDESPAIESPRISRESILKNMKSREESSELSEYHDTSHNSGNYNALPLDPDVPIPSLETDQPFEDETVIIKEEEDDDDMDLYSVPMFSGNDTKGETDHAEAPGHIVDDSSSRYSDTSKDDVPTPPGGAPHNFEMGAGELTPTKSVHSPQYPEHDLLASSMSGPDADPNFDVQFTSYIDQSTPPAEDRLAQPPPIGQENVRNSLDRPGSPDSVIRHPISPAESPDQSLIVPEPIATIKAPGGTYKTRTSLTPADVSTMAATRRRVSGQDVPVSPIEEFKPLPRVEQPVKEEESTEPEQPKERKPLELAPLPEKSRISSLVKLDIKVDSGSDGFGLDAEFDRVMEAQKVAFDIPFSQLSAQISGAGNSAQDASSSSVDRNTADTTTTKQRGYLMRQNTKMVVATSRPEDDANTESLTAPNSPRKASQQTWTTEPWTPKARRQSIKMSGAIPRKKIAEEPVPPLPGQESTVKDAANDAEETVEAETGDGCDNTEEDGDRGRLFVKVVGAKDLDLPLPRGERSYFSLTLDNGLHCVTTSCLELGRSAPIGQEFELVVMQELEFQLTLQMKPDQIKPKPQPVRPASPTKAPKPQKSSAFSRVFASPKKRREMELRQQQEAQQLQKRQAEEKALANIIDPWEKVRKVVDKDGNFARAYVSLADFEEKAFGRPLTVDVTCFNEWAIDETVSSVKSKRSTATTVSRRPPYKIGTLELQLLYVPKPKGATDDDMPKSMNACIREMREADHAAARNWEGFLSQQGGDCPYWRRRLFKLQGSKLTAFHEVTRQPRATINLAKAVKLIDDRSSLTQKETSAKGGRRRKSAFAEEEEGYMFVEEGFRIRFGNGEVIDFYADSRAEKDGWMKVLSETVGKCHSSGSGQAKPWTDLVLRREKNLNIKRPVEDKKPTVEERKLVRHSYAPPPPPKEQHIGQSRPTPGGIPRPRHQPQLSQPNINSQEARRQKTRSLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFI9</accession>
    <name>D4DFI9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019971.1">
        <property type="nucleotide sequence ID" value="XM_003019925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFI9"/>
    <dbReference type="GeneID" id="9584724"/>
    <dbReference type="KEGG" id="tve:TRV_05939"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_7_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11951" checksum="2D11587312F1DBAF" modified="2010-05-18" version="1">MDSFNNVKQWLQEIDRYATQGVNKLLVGNKSDMEDKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTATVNNKPTVQVGQGQGVQSNSGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGD4</accession>
    <name>D4DGD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COMPASS complex subunit Sdc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000352">
        <property type="protein sequence ID" value="EFE39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025834.1">
        <property type="nucleotide sequence ID" value="XM_003025788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGD4"/>
    <dbReference type="GeneID" id="9583644"/>
    <dbReference type="KEGG" id="tve:TRV_06237"/>
    <dbReference type="HOGENOM" id="CLU_1741892_0_0_1"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15677" checksum="07488D9BB82372A9" modified="2010-05-18" version="1">MADAPSQLPAGNSLPSGAGFQNAERQNNGETPQDRPAVMQENTPLESNSTPKLGASFPPPPATASTASRGVTPSVDNETAANKHHDNRDIIMSGGYETRGTYRGNGATGTAGVVNVTPQPQATGAPARIYMNEKIVPYLLEGMKMVAKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGG1</accession>
    <name>D4DGG1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000355">
        <property type="protein sequence ID" value="EFE39062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019707.1">
        <property type="nucleotide sequence ID" value="XM_003019661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGG1"/>
    <dbReference type="GeneID" id="9583605"/>
    <dbReference type="KEGG" id="tve:TRV_06265"/>
    <dbReference type="HOGENOM" id="CLU_007201_2_0_1"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="100600" checksum="7CEE0B9EA146DE79" modified="2010-05-18" version="1">MVLRTYTTTNTSAPETSAPFSTTTAATTTNATNAGAGQIAGADADTEEANQVNQSVHDGLYSVSNAGDTPSSTGHHAHNIPGAAGGAPNSNTSTASGHTSMHFDPVGRAAPTTPANMSSTGSLSPVLTSSTTNNVHRREYRGSSSDRLHAGVQSSSSHGLHTSVMRTVVSSGNDALNILFQAAAQEQDNEMIDVESTDRRPSMSKEGGAGDDVNGSAAAGTGTGQERPYSQHQKTQSHAGIRTYDTPTSTTSYGGSPTSDPTQLSHVEPDVLAVWDQCRFVKMGWFSSREAVTYVDMFFKNMAPLSPILSHFYSHHRNHYWLISQEPVLCCTILMISSRYHTLPGVGGASRGFFIHQRLWQHCQHLIMRVMLGQEKGSKAKTRTVGTIEALLVMSEWHPRSLHFPPESDGWDSDLMMDNTPEHHDSTSPDSSVSASSRWLEDVIEPARRSDRMSWMLLGSGLTLAHELGIFDTDDSRAKSLISSPEGEHQGFPVEETMNFPRHRIRQLLYVFINQLASRLGCMSLMPQSLNHSIVAPSSLNTGIDEWQTFMNSWIELTKLAKSVTDMFFPSATFTRQQLHSGRYIGLLDHFRPLLSQWRQKHLDSKRKCDALHIILTPLIIILIDLSRPFGDMIFIEYQFVRVYTNSIGMQAVVERVLNESDPDVVMDDVRQANMDEIDYEFIQEVIDGSCSLLQKVTTLAENGALRFSPVRIFLRITSSSIFLLKALSLGVRNAKLQESLDILTKSIQALRSSSLDDIHLASRYATLLDSLLSRLRRSFVLSNKNPKVSRSTTRPSSVTPLPKAQNASPATQGLQASPQQPQQQQQQQQLPHPLQQAQVQQYSPGGVCSAPMNSSMDVPNNPVFEDPISSLNDISADDWLSLPFDPSMAPFGDGGNQAWSGFEGANLNFIWNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGY5</accession>
    <name>D4DGY5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019566.1">
        <property type="nucleotide sequence ID" value="XM_003019520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGY5"/>
    <dbReference type="GeneID" id="9578340"/>
    <dbReference type="KEGG" id="tve:TRV_06440"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="34177" checksum="157F62BBB2DA915A" modified="2010-05-18" version="1">MISRFSGQITGPFDAELVKALPNSLAYICHNGAGYDNIDTTACSERGIRVSSTPIAVNNATADITMFLMLGALRQAYVPISAIRAGQWQGKTKLGHDPQMKVLGILGMGGIGREVSRRAKVFGMRVIYHNRNRLSPALEEGAYYVSFDQLLAQSDVLSLNLSLNATTRHIISHREFAKMKDGAVIVNTARGALIDEKALVSALKSGKVSSAGLDVYENEPCIEPELLDNPKVMLLPHIGTATYETQKEMELLVLENLRSCLQSGKLITPIPEQRDAWKSQAGTGISNCNGNNNGTNGRQNNGRNGHNGHVFHGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH79</accession>
    <name>D4DH79_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019454.1">
        <property type="nucleotide sequence ID" value="XM_003019408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH79"/>
    <dbReference type="GeneID" id="9577904"/>
    <dbReference type="KEGG" id="tve:TRV_06534"/>
    <dbReference type="HOGENOM" id="CLU_021768_1_2_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="34146" checksum="1AF72E2965C66A12" modified="2010-05-18" version="1">MYTRNPSLYPLPSEELLQIHSKIATALHLFSVEDDISLGWLRSPYTQISKRFYPYRGSLVQQLPFGLYMKNCHRARYNEVKALQIVEQHTSIPAPLFIDTFGHQGKVMLVMTRVRGQQLQEVFYRLSYPERAQLSADLHSAIKQLRAIPNTTPHRFANVLGGPLLDVRLPDSHDRARGPFDNELDFHDALIHKFIFAETKQAVAHVHSRSYRSFFSHADLNFYNIIIERGKLSGIVDWECAGYYPEYWEFTKGIYIIEGAADREKIIRDAFPDEDYQDELEAEKVLWFAAPPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHN6</accession>
    <name>D4DHN6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019288.1">
        <property type="nucleotide sequence ID" value="XM_003019242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHN6"/>
    <dbReference type="GeneID" id="9577610"/>
    <dbReference type="KEGG" id="tve:TRV_06692"/>
    <dbReference type="HOGENOM" id="CLU_072870_0_0_1"/>
    <dbReference type="OrthoDB" id="4171120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056512" evidence="1">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="323" mass="34779" checksum="4067C1CB8C9130BB" modified="2010-05-18" version="1">MPPLKLSSVTFVLFLIPFTIGAGDTDLIGCNSVGCPTIDGYDRCTVEDVTHIGVGLSRIQNAPSELEGFSLVKGVNVSNKANEDPGLPFNSLYYLSVPETADTGKLHGCTVVFNDPPFKKFKYPMKEGKIAGTSVIVNMTDSRAAAGMCSDVIEQSCIDKILQNASDVADEGSGNTCEKLEREMKKNFDGCTSFGGPGTSLGNFTVKSLDALSTVKNSSDCWPTKQKSDRLLEIARATSYGNETDTYDEYTKEAYKITPVLTLFVGGNGSLIDHTSSQMTCLKVITTKKYDVEPGRPENKAIILRGSWVSLVIVGLTAIFMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV5</accession>
    <name>D4DHV5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019213.1">
        <property type="nucleotide sequence ID" value="XM_003019167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV5"/>
    <dbReference type="GeneID" id="9577210"/>
    <dbReference type="KEGG" id="tve:TRV_06762"/>
    <dbReference type="HOGENOM" id="CLU_047846_0_0_1"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="43644" checksum="EC3C8552F58C7FEA" modified="2010-05-18" version="1">MNFFSIFDFLDEARERKTHDQLQNTKSSIHLAFYTRQFESLLKLCQPLQSIFAAALVPKFAPTSSPELDGLLQKFRDKLFIPAWLPYEDKRAMYKKSKSQELLSHPVVVNVGTEDAVDNYTLRPMHIADAPSNSEVARVIRLLKTEEDWKSLIPFLSGLHSSKRDLTPHTTEMLIRRAGDLGMEAHVLQAVAQAHRTGLLMRNADFTRTLLFSIRLKAEKAGFKGPDVHLALGQAKELVRLLNSPEHTHPVAEKDPKRLPSVIGMLLELKAAYAMDAFKGRDEDQGVRSYANKLISTWPLEKFTVPSEWPTANWRLRTYVPLWHGMDLALKVEEIKAQPDIRQGLEARRGELAKAIESCLQTVDKHRQEVTHTVSWTKSLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHY6</accession>
    <name>D4DHY6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019187.1">
        <property type="nucleotide sequence ID" value="XM_003019141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHY6"/>
    <dbReference type="GeneID" id="9577190"/>
    <dbReference type="KEGG" id="tve:TRV_06793"/>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="OrthoDB" id="4132742at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="52435" checksum="8F8235EDF1D9D399" modified="2010-05-18" version="1">MQFDHVAEDRLDIVFAQWVKQLLSKSPEHLAMKLAASHLGRRAKQACQWKTGAFNVCYRVQFHDDTPEVIVRFSSLGRSIFRAEKVANEVAVLRYLRKHTSIPVPEVYGSGKTWTGPYIVLTYVHGTPLASILKDPKAEGRPILNSNISQRGLRRAYQEMAQLLLELSKPEFARIGALVERSDGEFTVSRRPFTFNMNELSTSANAPPYVLPGPNAVFDSAADYFKSLATQHMLHFLTQRNDAITNEADCRKKFVARCLFSKVVEAIQFHEGPFRLYCDDFRPSNVLVDIENIRIAAAIDWEFTYVAPAEFSYVAPWWLLLQSPEDWESDLTEFLTRYTPRFHLFLDALRAAECDMISNNSLQESQRLSPHMEKSLDNKLFWVCLAARYSSMFDEIYWTFIDEAYYGKFTSLEDRLQHLSQEEHTKLDAIYHVKVKQAEDGEIDPHYSLDDTMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI28</accession>
    <name>D4DI28_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019151.1">
        <property type="nucleotide sequence ID" value="XM_003019105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI28"/>
    <dbReference type="GeneID" id="9580099"/>
    <dbReference type="KEGG" id="tve:TRV_06835"/>
    <dbReference type="HOGENOM" id="CLU_219187_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="40" mass="4823" checksum="EDE813236CB38D56" modified="2010-05-18" version="1">MTAWGREDSGEEDDGDEEEKEEEEEKKKKKKKRKKKMEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI37</accession>
    <name>D4DI37_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019160.1">
        <property type="nucleotide sequence ID" value="XM_003019114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI37"/>
    <dbReference type="GeneID" id="9577157"/>
    <dbReference type="KEGG" id="tve:TRV_06844"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="435" mass="47628" checksum="9994ED424BE19A38" modified="2010-05-18" version="1" fragment="single">AEFGNLDDHENPKKWPMLRKWKAMLGISSFVLMSPLSSTIVGPSLPSIARDLSITRPAEQALVLSIFVLPYAFGPLLASPLSEIYGRVPVIQSWNFLYLVFNTACGAARSKSAMFAFRFLAGFFGSATLGIGGGTLGDLFTAEERGKAVAIYSVIPLLSPIFGPILGGLISQHISWRWAFYISSLSDAVIQILGLYLLEETYAPVLLRKKQRRSVQLASPNQQLRSSTKDILKELPIRLKANLGRAVLLFTTQPIVQAFAVYNAFLYGIIYTLYTTFPDLYTNIYHQTEGMVGLHYIAMGIGMVIAAEGFTLVNDRIFAFLKAKNNGVPLPEFRVPFMAPATLLIAGGLFWYGWSAQHKLHWVMPDIGSGLFCAGAVICGVSANAYMIDTYGKFSASALAAVGTLRSLTAFGFPLFAPYVYVFPLHAAIYLLINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI53</accession>
    <name>D4DI53_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000396">
        <property type="protein sequence ID" value="EFE38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019113.1">
        <property type="nucleotide sequence ID" value="XM_003019067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI53"/>
    <dbReference type="GeneID" id="9582601"/>
    <dbReference type="KEGG" id="tve:TRV_06861"/>
    <dbReference type="HOGENOM" id="CLU_1726753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="16556" checksum="9A3741DB1655A365" modified="2010-05-18" version="1" fragment="single">SRTAKRRPRLSPATPAATTNQPQPQPQPQPPPPRQPTADSDSNNDNNDDNDDDDDDDDDDDDSDSVNEYSCRPPTLATAAAAVDLPRLLLRRTAEGQPESLKAALDQIPPFLAGPCCVSLGLPLSLSRQPRSKGIWIEDEPVEQQYNKSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI69</accession>
    <name>D4DI69_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OB-fold nucleic acid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019098.1">
        <property type="nucleotide sequence ID" value="XM_003019052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI69"/>
    <dbReference type="GeneID" id="9582584"/>
    <dbReference type="KEGG" id="tve:TRV_06877"/>
    <dbReference type="HOGENOM" id="CLU_054798_1_1_1"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="282" mass="32978" checksum="7C0CFF14D22102B9" modified="2010-05-18" version="1">MAHGVQNTHKEELIPPDGLTFYPAYCYKASPTHFTWVKLSAVNVHRLTRRSGYEGQNIYFYKNHPIQFICLAGVIVSREEHVRRTILTLDDSSGSNIEIVCSKRQVELPDSQPVKAKTGAAVAAADPQRVSEYITSTTKEALDIKSLVPGVIAKFKGTVIKFRNIKQLHLERFVLLPDMDGEMRFWEERTRFLVDVLSVPWYLTPEQVEQLRIEGAGLEEKKKKRSKAKEHEKERRERRRAEREEKDYERIVRRYQREEEVRRKYAESSREVSARFRKSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI82</accession>
    <name>D4DI82_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytomegalovirus gH-receptor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019065.1">
        <property type="nucleotide sequence ID" value="XM_003019019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI82"/>
    <dbReference type="GeneID" id="9582550"/>
    <dbReference type="KEGG" id="tve:TRV_06890"/>
    <dbReference type="HOGENOM" id="CLU_003655_0_0_1"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="967"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125204" checksum="A05E602659F1080D" modified="2010-05-18" version="1">MTSDGFHTMNGLGIDDGEGKGEISPDTMVGSSLLNGGKQRSEEADELEYEEQSAASPEPVLAALVQGKQEDKARDKYVGISSSEVNTVAAVEVGDNVDGRQLPSPAPTPEPESQITIWAENATDEDPTALKRPHGQIPRPAEADVTLKDRSYTSSHPSKSNKQSAGTDATKERDKVQKLSPAKLQDLTSSPEFACLRVTDDADTDIEVDAEKSQVQQQIPPSKPVLDLASVEVETGPELEPSTAPLISLKEKDEVVGVYDVDMGTVSGSSGALKDRNRSRARTRRSSTGKKQVHLQNPLEFHGRRVNSDPSQPLPTSFRPRDKASSVSGPVPVAGRERLYDNGSGNRSRRMPSPLKLDAGSRSTRSSGVNRSVSPVPASIPIPPFSIPTYLQLELSSHRPSSLYIHRSGAHDFPYESSRVMLERLQNFFLLPPLLEQALCFGTLACLDSWLHTFTLLPLQFLKAVYILLQSWMINLGLEIRFVTSYIVSGLGRMWKRRRRRDSVRETTHEKPINIKDSSPKLIPIDLSPIDGSPALDPASGSEARRRRGSTTRRHRRTKSIPSTLLENDKADILKGLLMIFTCTILMYFDASRMYHWIRGQAAIKLYVIYNVLEVGDRLLSAIGQDVLECLFSQEALERRPDGRSKVVRPFWMFIFALIYTVIHATALFYQVMTLNVAVNSYSNALITLLLSNQFVEIKSTVFKRFEKENLFQLTCADVVERFQLWLMLIIIASRNFVETGGFKLGNALTSQSSATTTTNSTTAFRPSTSILPQSFTLLIPSSVFSSLSSVNSILPAIGHLLAPFLVVLGSEMVVDWLKHAYISKFNNLKPAMYGRFLDILAKDYYGSAFSDPNLNRRLGLPVIPLACLFFRVSVQTYQMFLTAWLPQLSSSPFYPPPSNATSLTEIHSHYAPISGSSASLSSILPDFSNASASTILSSISLSTIAQAASSIFQTLVSYATPSPESFVPIFTVILVLLLYITLLLGKLVLGMILLGYSRTRYKNMKYREREYAAQQKREQRRQQQQQYMKSTSPLPHVPSLPAQTIESSSFNSASNSNSDMIEGGRRGGGWGAVEVGEDKRRWIYVDDPEGLRRLRDREAKSRSDNPGGSGSGAHGLENVKRYEMAAKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIZ5</accession>
    <name>D4DIZ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000417">
        <property type="protein sequence ID" value="EFE38194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018839.1">
        <property type="nucleotide sequence ID" value="XM_003018793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIZ5"/>
    <dbReference type="GeneID" id="9581483"/>
    <dbReference type="KEGG" id="tve:TRV_07159"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="293" mass="32945" checksum="CD6B51D04B28213A" modified="2010-05-18" version="1">MHCYFVLSGDSQLPVLYHVERVRDGRSFATRTVQARQQGRPIFTTTLSFDREGSWGKKEIKHTRKKPDVPLPGQPDGLGRGRGPFESRRVGITNRDSPHAADRSLQLYNKARGTISAEGGRQAHLTALAYMSDSYFIGTVSRVHNIRRFSSPGAIERAAAALKKEVGGEEELAKRYLTDLAEQEEQELKLSKQTSDDPNMEVGMMVSLDHTIYFHDRRAFRADEWIFSEMRTPWAGAGRGLVLQQMWAQDGSLIATCVQEVTKKIHNLCYISFSIRPLSPNLKAPLQSTRPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ40</accession>
    <name>D4DJ40_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018770.1">
        <property type="nucleotide sequence ID" value="XM_003018724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ40"/>
    <dbReference type="GeneID" id="9581165"/>
    <dbReference type="KEGG" id="tve:TRV_07205"/>
    <dbReference type="HOGENOM" id="CLU_090028_2_0_1"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="150" mass="16024" checksum="94027861AC68C1F1" modified="2010-05-18" version="1">MAPKNKGGDSKSAGGKGKGKGKESESSDSGKGKGLKAANSINVRHILAGKAGSSLDYLLTIYRGQCEKHSKKEEALEKLRAGAKFDDVAREFSEDKARQGGSLGWKVRGSLDAAFEKAAYELEPSTTGNPKYVEVKTGFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ51</accession>
    <name>D4DJ51_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018781.1">
        <property type="nucleotide sequence ID" value="XM_003018735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ51"/>
    <dbReference type="GeneID" id="9581177"/>
    <dbReference type="KEGG" id="tve:TRV_07216"/>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="8">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="486"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="554" mass="64016" checksum="5D873451025DD747" modified="2010-05-18" version="1">MALRQLLLYGRTSMRQRKLDISLTNKTNLRTLTDLKRTSMSKETNELFSYTSGRWLYNEEKQLKARYVEFDIEALKKCASTILGSPCVQLRKLPEGLYNKVFSVKMENGKDVIARIPNPNAGNPKMVVSSEVATLEFVRETFDSDFDEDEIGAEYMLMERVGGRQLSEVWDNMSERQRFNLVKNVVEIERKLVNTPFTGYGSLYYKDAYEESYPGYLKAINAEKVPGKENEVSRFVIGPTTERAFYADNDEKQNISHGPWETAVEYLAAIAKREICSVQNFNLASPGDTLPFWERVSTPSSSKLHVKLLEQFITVLPYIIPPSEIIQPILMHQDLHFDNIFVDETDPSKVSGIIDWQATYSSPIFMQSRFPSIFDCEDPYTWGAVHLTLPEHFDTLSIEEKKLAEDSLDRLRLKKFYELASRKMNPLLAKAMDAMRNDECPTSFIFYIVQQSAFDGPIPLRELLIQIYEQWDQITRRNGVTLKCPISFTEEEIKQARQQAEEWGESFSEFENFRASLLGKDGWVPHEQYEEAKRAFENSKGELERLRNGLEHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJM0</accession>
    <name>D4DJM0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000439">
        <property type="protein sequence ID" value="EFE37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018597.1">
        <property type="nucleotide sequence ID" value="XM_003018551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJM0"/>
    <dbReference type="GeneID" id="9584524"/>
    <dbReference type="KEGG" id="tve:TRV_07388"/>
    <dbReference type="HOGENOM" id="CLU_997649_0_0_1"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="29691" checksum="DE726BCB6432DB3B" modified="2010-05-18" version="1">MDSMRSLNKSLPSTTAAQPPELLLQAFKTAALSVTNLYKNAVSDQAQSRQLGYQDALEDLRAFLDKEKIGFTDGEGQKIRNWVMEKIDMAGTTSNDSDDDKTDADKTNRAASPAAIRKTNSDTTASKPQPEAAAPSRQPSETPPPLMPIPSEPIAIVPPRTAAFTFTAGQSLPMQEDIDMKAAMDSSPSLSSDPQITTSHPSHPPVRLEVHSRPPRTPHRHGSGNRHNPRSINRDPTPGAGSKRKFHFGEFFDISNLGNGRDPFGGPKRGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJQ6</accession>
    <name>D4DJQ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018579.1">
        <property type="nucleotide sequence ID" value="XM_003018533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJQ6"/>
    <dbReference type="GeneID" id="9584508"/>
    <dbReference type="KEGG" id="tve:TRV_07424"/>
    <dbReference type="HOGENOM" id="CLU_1200564_0_0_1"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26461" checksum="6571649D70C8B250" modified="2010-05-18" version="1">MHAEGMDDVFSTEDSTGTTLASIFECPVLRKAVFDVRGASDYLFHECEVTLDGIVDIQLMELATRDGSKEFLRGLATCICNDSSLSAKETLRWQESNDFKNYIFRPEVDESCIEKYMETPLRTEMIDHCAYSLVVLSRLYDVYDARLKQGATKFWKTEIRSVTKARINDTKKEEFDVYDRENAYGPWDEEELKMKMERRDSCPRGVTNRTGGKEFWDLLARNASGGSNIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK62</accession>
    <name>D4DK62_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018389.1">
        <property type="nucleotide sequence ID" value="XM_003018343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK62"/>
    <dbReference type="GeneID" id="9584333"/>
    <dbReference type="KEGG" id="tve:TRV_07583"/>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="76"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="441" mass="50201" checksum="8BD41E75B1BB4470" modified="2010-05-18" version="1">MSDYAASNHSPLAQETGKDEMSDCWDDETRSLDYEEDDTAQEDDYIPTDEADTESEHEEQDEAVLEDMRKLQDEAILRGKFRLINRVGEVYKAQDLTWNEGAFQADLLDPSKTLRGMKKQYVALKKIYVISSPARILNELEILHDLRGHPAVCHIKAAFRLDDQVIAVLPYFPHTDFRLMFRTFLVEDMRHYFKSLLEGLAFVHKLGVIHRDIKPTNFLYNPKLRRGVLVDFGLAEIMDSIRYSKQAPVGYPRNDTRPSRRANRAGTRGFRAPEVLFKCTSQTTKLDVWSVGVILLTFLARRFPFFHSMDDADALIEIASIFGKNKMQLTAAEHGLVFDTTIPTILPKGHSLERIIRWSSSVVELTGRELQAVNLLEKILEPSAIMRWSAEGALYHDFFNNPQGADLPWGGEDPENLEHHSAQGDDNDDTACDAGDEVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK0</accession>
    <name>D4DKK0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018272.1">
        <property type="nucleotide sequence ID" value="XM_003018226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK0"/>
    <dbReference type="GeneID" id="9579968"/>
    <dbReference type="KEGG" id="tve:TRV_07722"/>
    <dbReference type="HOGENOM" id="CLU_054442_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="46846" checksum="C59EC6BAE3A4CC67" modified="2010-05-18" version="1">MVYFSHHALLSVGMMKIPLPSRQSLWDAPSAVKWEDEMRQLKKTTRSRYFSLDSAVQSILSMKDAEHMREVLHWHSTPSPLSLHILIHGITSAIGDAKYRSVSSSSSLVIRELQRLEFDSALAYWRDQFDQLSGPDQRCQLSWCALVMYDFSAVLLRNNLSDIQMAAGSAFSSGRTVTSQVAQAAYTRLVSTDPVCHDSYLHALEVVGLCIEEGTSNGSVKPGLGVLLSQPISQPRPLWQTYCAFLGLLVLWARALGLENKEQSRNVSRIGLRQFSLQAIPSTAATILANMHHREQAQFSAASVEVQVLKSELRELIGTVSDRLSASSWEIFLEQYEEIRLIHPSTYSPNIRLSGCCFNQVDVLLRLLLSIYYIHPHTYIFGTQEAYGLLASINIGQADTLSIYDSHGSLYLFLYSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKL4</accession>
    <name>D4DKL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018286.1">
        <property type="nucleotide sequence ID" value="XM_003018240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKL4"/>
    <dbReference type="GeneID" id="9579982"/>
    <dbReference type="KEGG" id="tve:TRV_07736"/>
    <dbReference type="HOGENOM" id="CLU_012062_31_0_1"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="456"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="602" mass="66988" checksum="367B90111EAA4B35" modified="2010-05-18" version="1">MSEVAGSSEKAANVRLHSQVEEDEREADNSSSDDDYGPALPSGPLKKKKRRELPYEKLYIKALPASPRYSKSLMHRDQLAYVTVTPHTDFIITSSIDGVVKFWKKMAVGMEFVKEFRAHMGEIKGVSVTSDGRSFATIGGDKTMKVFDVITFAVTSEEDNTILIFDGRCEKTTPLHKLNSVHRAPVISMAFNNAFNCVISVDNKGMVEYWRPDEPFDKPEGVFDLKSSTDLFIFKKSKSLPSSISISPSGHRFATFSFPDRQVRVFDFASGKLYRSYDESIQTVTEMQQAGTALQKLEEVEFGRRLATERELGNPTTAPKVNVIFDESGHFILYGSILGVKCINTFTNRVIRVFGKDEPFRALNLGIYQGQPQKKGVVTVSMAASSNPLLQEAEERDPILITTGFAKVRFYLYTNETEISKSTRDVQNEKPIHDKGGADTASAAKPAETGTSAILHTTLGDIHLRLFPSVAPKTVENFVTHSRNGYYNNTIFHRVIRKFMIQAGDPLGDGTGGESIWGGEFEDEFSSLKHDKPYTLSMANAGPNTNASQFFITTEKAPWLDGNHTIFGRAVKGMDVIHKIENVKTHKEKPEEDVKIVSISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKM7</accession>
    <name>D4DKM7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate transporter Pic2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000474">
        <property type="protein sequence ID" value="EFE37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018245.1">
        <property type="nucleotide sequence ID" value="XM_003018199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKM7"/>
    <dbReference type="GeneID" id="9579616"/>
    <dbReference type="KEGG" id="tve:TRV_07749"/>
    <dbReference type="HOGENOM" id="CLU_039456_2_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="275"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="351" mass="37728" checksum="DC376B040F144341" modified="2010-05-18" version="1">MSSTFPDSLFSGEASVQDPYSKCGVYPGVTGSLKRTPFPAWSVAEDVKRNTRPSQEVGSMGSKGSGPAGKIELYSGKYYASCITGGILACGLTHAAVTPLDLAKCRLQVDPTMYKGIIDAWGKIGRAEGIRGIFTGWSPTFFGYSAQGAFKYGGYEFFKKYYSDLLGEDISSRWRTPVYLAASASAEFIADVALCPFEAVKVRMQTTIPPFARGTFTAISHVTAKEGVAGLYKGLYPLWGRQIPYTMMKFASFEKVVEMIYNYLPGQKSDYNKGAQTAVAFAGGYVAGILCAAVSHPADVMVSKLNANRLPGEGFGAAIGRIYKQIGFVGLWNGLPVRIVMVGTLVCTFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR7</accession>
    <name>D4DKR7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018216.1">
        <property type="nucleotide sequence ID" value="XM_003018170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR7"/>
    <dbReference type="ESTHER" id="trivh-d4dkr7">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="9579587"/>
    <dbReference type="KEGG" id="tve:TRV_07791"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055609" description="Secretory lipase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50423" checksum="77B6F0080CAFAFAD" modified="2010-05-18" version="1">MMFLTQLVSALFFFLLSPISYGKPVGTFVLPLAQDAPIPPSEDPFYQPPPGYEETEPGTILRHRRPPFPISLFRSAPIDLAATYQVLYRSSDTFGHPTATVSTILIPHNANMSKVLSYQVVEDAAFINCAPSYALQLHSDPGGLFGTIIIQSELLLITAALENGWVVTIPDYEGPAAAFLAYWRAGYATLDGIRATLASSGFTGVDPDAAVGLWGTSGGSVASAFAADLHPTYAPELNIVGAALGGVVPSITTALHSLNKGFDAGIIVSGVIGLSKEYTYMQPILESYLVPHLRDKFMSAGKKCSGAVSLDFRMEDIFRYFKGGEESGLFADPRVKAILDHNAMPQGVPSIPVLILKSINDEISPISDTDALVEKYCSDGVTIDYKRDLLSVHTILAVTGAPEAVLWLRDRLDGITVEKGCKTSTIFMTLLQPGALEVMSKTIIDNLLNLLGKPVGPRLRTEIAHVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR8</accession>
    <name>D4DKR8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018217.1">
        <property type="nucleotide sequence ID" value="XM_003018171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR8"/>
    <dbReference type="GeneID" id="9579588"/>
    <dbReference type="KEGG" id="tve:TRV_07792"/>
    <dbReference type="HOGENOM" id="CLU_068318_0_0_1"/>
    <dbReference type="OrthoDB" id="4174403at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055951" evidence="3">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="349" mass="39362" checksum="AEB098CDB83029D4" modified="2010-05-18" version="1">MGRRRGLSASLCLWLSGSTGSPTLKLRLPACSPAPARCCEALLHCWGFALAGNFLQRYHTTSTARQQHRHCTVTASSLHRHRSTLSDRITHGSMDGVNLVQRVSMSLRAGTALGRRDAQSHTEQEEYLTYAVFMADFIPFLAVAIYILLAVVIGWKYLGIDVEAYGGCYELEELEQGDDGGSRGEEEEEDDNDNEGIFLLHYIQSGQAPQQQERDQAEPVHKPPLDDSRHSLDNIITTTPNGISKYFHPTSGRLRDDIVHPTQTRLDRMLGDDEDEGHGSIAWYKALQRFSDKFILKAQAWLDKDEANIDRVEHRETSKVCGESNRVVRQILRERREEGGYKDAEDNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ4</accession>
    <name>D4DKZ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator PacG/VIB-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018172.1">
        <property type="nucleotide sequence ID" value="XM_003018126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ4"/>
    <dbReference type="GeneID" id="9579543"/>
    <dbReference type="KEGG" id="tve:TRV_07868"/>
    <dbReference type="HOGENOM" id="CLU_019472_2_0_1"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="71"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="71"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="588" mass="63628" checksum="4D9161D875DA2CF1" modified="2010-05-18" version="1">MRRFSSSQFEEPFPEIADMIPATPFDVDMQQQQQQHQQHQVQHQQQIQPQHQHQHQQIQHQQQQQQLQPQPQHGQGTGQGTEEDSIDHGHKLLSFSVPAYNFTLLDYSLRRTSLNMTAQLHGMFFLAESSWSASPGGDTPVSVNTAAPAVGMGMGVGVGVGVGPAELTCYRRNLFQITGSVTLPRTLRYIMTEQGDRIPILAQELTVSATESVEGNPVKIISVPWKTPAGGSSSANASGSAGGAGVGGSGGGSGSGSAAGGGMVEDKTEKEPAPVVLDTMGGQDADADFATFSIAWKRLQFRIATANNGRRRELQQHFVLRLKIVATLSTGAKISICESQSGPIIVRGRSPRNFQSRKDVPLSGSAAASRKNTQAAALARANAGGTPANPAGSVSAGGGKRNSPVKTEERAAAAAVISDPSAAAAEEEEESRSSKRRRMSSGIPPITLTFNDEEASSPHSLPIPELEQQLEQPERKRSTSHYDGPLNHHPLNQPLNQHHQHQHHPLNQHQHQPQSNHHQNHHQNHQLPAIMGEAEDRADVLYEYFPLALEEWQAPVDAVYRPHVVHHTALAGDAKALAARRSKVYFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL78</accession>
    <name>D4DL78_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000495">
        <property type="protein sequence ID" value="EFE37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018028.1">
        <property type="nucleotide sequence ID" value="XM_003017982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL78"/>
    <dbReference type="GeneID" id="9579168"/>
    <dbReference type="KEGG" id="tve:TRV_07952"/>
    <dbReference type="HOGENOM" id="CLU_039212_0_0_1"/>
    <dbReference type="OrthoDB" id="3786931at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="60145" checksum="B41AD9D7C7E18B03" modified="2010-05-18" version="1">MTQLKVEDLSREDVKKLARILFLDVKKFQEREAAAKLTTELPSYLRRSRLLSLMVDKLNLIREPAKAACFIHKTLNREISHALCGLIRAEVGEGLNGLVSRQTRLSIEQRRMIHNLRTVNGLWMTREAVERKYLIRPSFTWYYQSDGCEACMVSRFARDRAALTDMRTLLLSRIGRRKNRNPPQLVRWVEELMSCHGPSSLEMFVFSAEDALELKAVRRDVRGTQSQGQNAATGQGCGLRRAESNVTHRPTRWTSVNTRQASRRPRSMETLRSPDNSALPTSEAEVDTANEIIDCYLNRTLIDVNPEPVTAQPERQQDRTIPDPKTRLQPEPESEQRHRIDRAECHRPTSASQMKRSESLRIAMAACSETRRNTQIQPLRSPSISSSRAGTRYEYPSRRTQSVYSNGGNYSKMNQNVHKPVCQNNDHRSSRLTRSQTIKTSKEQAAEYRSLLGEMHRLSCYSPSNYSRATLVEGSGIPNPRLEEKRPVSEATTRWSTFDGGEGLYSPIEPIPPLRIRKEKRRIGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLL4</accession>
    <name>D4DLL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017922.1">
        <property type="nucleotide sequence ID" value="XM_003017876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLL4"/>
    <dbReference type="GeneID" id="9579800"/>
    <dbReference type="KEGG" id="tve:TRV_08088"/>
    <dbReference type="HOGENOM" id="CLU_007884_7_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="409" mass="45242" checksum="325F1C97ECD922D3" modified="2010-05-18" version="1">MVQGLTSSPICGRCLLRTRRQLLRNRIYSQIRHNHTNPPAPPPSGYSHLNNRSLISISGIDSTSFLQGLITRNLSVPKNSPPVTSPFYAAFLNSQGRILNDVFIYPFETASSPAGEMEYLIELDKETSEGLLKHFRRHKLRSKLKFRALDDGERSVWSIWDDGNTSAWHESEAFKENNAIVCPDGRAPGMGYRVIASGGKLPSRITEAFPGDETSIEAYTLRRMLRGVGEGQIEMPRESALPMDSNIDIMNGIDFRKGCYVGQELTIRTHHRGVVRKRILPVQLYESTKTLPTSDMPIYDPDTSITPPPSGAEANISKVGASKGRSAGKFLNGIGNVGLAVCRLEIMTDIALTGESTQYDANQEFKITWDSTEVGGANIADQPKVKAFVPPWIKEYILSGGARHRQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLN3</accession>
    <name>D4DLN3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000515">
        <property type="protein sequence ID" value="EFE37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017883.1">
        <property type="nucleotide sequence ID" value="XM_003017837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLN3"/>
    <dbReference type="GeneID" id="9583777"/>
    <dbReference type="KEGG" id="tve:TRV_08107"/>
    <dbReference type="HOGENOM" id="CLU_1723652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16955" checksum="956DF993BC37BCE1" modified="2010-05-18" version="1">MAAESVTLDNLEEVLEDDGQVKVAGFDADGILRGKLVSKRKFLSIAQDGFGFCSVIFGWDMHDQTYFKELGISNKENGYRDLVAVPDLSSFRRIPWERNVPFFLVSFLDPETKKAISACPRGLLRTATAGLEEKGYRAMAGGMIRTTPMHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLQ0</accession>
    <name>D4DLQ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNF7 family protein Fti1/Did2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_08124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017868.1">
        <property type="nucleotide sequence ID" value="XM_003017822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLQ0"/>
    <dbReference type="GeneID" id="9583763"/>
    <dbReference type="KEGG" id="tve:TRV_08124"/>
    <dbReference type="HOGENOM" id="CLU_1315099_0_0_1"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22687" checksum="2C06784C565A529E" modified="2010-05-18" version="1">MGMRDPLLEAMAEVKVNGNQLRKQAAKAEASARAQEDKAIKAMKKGQFQISRIHASSAIREKRRSVTLLSKSAEADVIYSDLSAAKSTRDSTRSLMKASKALDSASRSINLERTLAVANQFVSRSEDFKLAGSALEGVSKDVQMQEYGAEGDEDVDRLMERLADSAGVDLRQGLEENAAPREELTVANKQKEAEFEDGLAGRLRALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLS3</accession>
    <name>D4DLS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_08147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000518">
        <property type="protein sequence ID" value="EFE37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017852.1">
        <property type="nucleotide sequence ID" value="XM_003017806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLS3"/>
    <dbReference type="GeneID" id="9583746"/>
    <dbReference type="KEGG" id="tve:TRV_08147"/>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="291" mass="32886" checksum="936A27FE33C5B21A" modified="2010-05-18" version="1">MNSDMDPFLQVQAYVWPPSQLPTYIRTTHLTTIYNRDILSTLSTTRPLFSSYQRIRSLATSPSNPELIQAREELEATVADLSADLKDLVESVRAIEYDPYRYGLELDEVERRRKLVDDVGKEIEEMRQELQRTVHEHPGTTGKRASSGPSSASAAAAGGSGLPAPSTFDNLLDEEGQERGEDYYSEMEQQRQVELMQDQDQQLDGVFRTVVNLRQQADDMGRELEEQSVMLKDVDTLAERVGGKLQDGVKRVGHIIKKNEGEWALSSFPPFSIDTNTNMRQIQCRAAALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLU0</accession>
    <name>D4DLU0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_08164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000523">
        <property type="protein sequence ID" value="EFE37183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017828.1">
        <property type="nucleotide sequence ID" value="XM_003017782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLU0"/>
    <dbReference type="GeneID" id="9583722"/>
    <dbReference type="KEGG" id="tve:TRV_08164"/>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="473" mass="54437" checksum="E908546779D84485" modified="2010-05-18" version="1">MFISLSQLRLWVLTCEKRAISLFESINPATNRRYEIQLKGAGLTPYSRFADGKAVLRSSIREFIVSEVTRFAESWIRIGTFDLLRARSDLKLTRRLATYVAEDVFPGWESLPAALPTTQEKDKPVDGKLIDNPPRGVPKDEIQGEKGAEENRFARLYREIVRRNAKTVAAWQAYGFMNGVLNTDNTSIFGLSLDFGPFAFMDNFDPSYTPNHDDDMLRYSYKNQPSVIWWNLVRLGESFAQLIGIGDKIDDEAFLSNGLSEEQTSDVIARAEKLIDQAGDEFKTVFLNEYKRLMSTRLGLKTQKESDFNELFSNLLDTLEKLELDFNHFFRRLSGLTVAEIDSDEKRKKVASLFFHDEGVGGAGNTEESARESVAKWLSSWRERIVEDWAGCEDEERIRSMKRVNPKFIPRSWILDEVIQRVEKQGDREILGRTMNMALHPFQEEWGVNREEEERFCGDVPRFKRMAMCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ32</accession>
    <name>D4CZ32_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferric-chelate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025742.1">
        <property type="nucleotide sequence ID" value="XM_003025696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ32"/>
    <dbReference type="GeneID" id="9582000"/>
    <dbReference type="KEGG" id="tve:TRV_00069"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_0_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="224" mass="23712" checksum="3286A0103E75D34D" modified="2010-05-18" version="1">MTVYAKPYEGLTKSLQNAARDVSSLNLRVLIEGPYGGVSSGSMARFDSILIITGGSGAAFSFPIVEDVLRTCATADSADQVEGKTLKIIYAARSSLMAQWYEERIRALVSCYPSSSIVSVLIHTTSITSPLQSCISMSKEYASSGMDQTLNGEKDSSIIHEHGRPCLAGAVASLAEQAAGKSAGIVVCGPPSMLHDIRNAAAEAQKKVLAGDVKELYLHTECFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZN8</accession>
    <name>D4CZN8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025518.1">
        <property type="nucleotide sequence ID" value="XM_003025472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZN8"/>
    <dbReference type="GeneID" id="9581755"/>
    <dbReference type="KEGG" id="tve:TRV_00280"/>
    <dbReference type="HOGENOM" id="CLU_007408_0_0_1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="301"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="813" mass="89419" checksum="10756D1B5D38372C" modified="2010-05-18" version="1">MYIKSPAASIRNGMLRTSEEDVEETESTSSLPPHKPIVPAAKAAATRQPPKSQSMISRKPRTMPSLSQVFGEAPDSEPTGIIEPLSIPKTRKPPSTISSNFTSPTSTTSKQSPRTSITSDGYSATDIPPKEPEPKKTAKSSSALRESIAKAKAARKAAQQQQLQQKRESSLKSPDALEEDSLKDPFNQLPGMEPTGAALQSRTASARKSGLLNISAMGLTAIPNEVMTMYTFDPNSNDVWYENVDLVKFMAADNELTSLPDEAFPDVDLAEFNADEPGPNAQFGGLEHIDLHGNKLSSLPMGLRRLQRLRTLNLSKNKLDSMDALDVVFSIESLTELKLAENNLSGMLTSDIGRLVKLEVLDLHGNCLTGLPDSIADLTALRILNVSENRLPSLPLMAMKDLPLTELNVWKNRLDGHFFPKAFKRHDTLQVLNIATNNLDELSAEDTIELPNLQQLFVEQNCLKFFPNISSWKSLLTIIASENRLSALPEGLADLENIKHLDFTTNDIRLIDDNVGSMESLVTLRISNNPLREKKFLGMDTDDLKRELNSRREVKEPSQDEEEGSVQTELTLAPESPTATITHAWRVKQRGVLDRSSTNLSDLEPLDIEPLIAKSDIRCLYLQRNHLEKFPVPALSLVAHSLIDLDLSNNPIGRTELSTPLSLPNLQNLTLSSSALTSLEPLIANLSAPSLSFLDVSINRLKGPVPVMRATYPNLVTFLASENAFDSLSYEAVEGLQVLDVANNDIDALPPRAGLLGVDDVPPGKNALRRFEVAGNKFRVPRWQVVSKGTEAILDHLKNRISEAEMKEWKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZX3</accession>
    <name>D4CZX3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025427.1">
        <property type="nucleotide sequence ID" value="XM_003025381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZX3"/>
    <dbReference type="GeneID" id="9581683"/>
    <dbReference type="KEGG" id="tve:TRV_00367"/>
    <dbReference type="HOGENOM" id="CLU_019706_0_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055207" evidence="1">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="106"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="404"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="547" mass="58974" checksum="2E3B8D8DD2169540" modified="2010-05-18" version="1">MMIRPFTLFLCILICSSSGLSFTPCPLLGPAFPEFTLDTGSEVLTSALKNLTKAFDKLVLEGNGDHGEIFPNTTSFSLSLFSVNEGNASDQPYFFDYHYTAPPLKFHPVGKDTIYRIGGLTEIFTVWTILIEAGDRIWNTPVTEYIPELADAVSYRNGKKNPVSYVDWETITVGQLASHMAGISRGSSMPDLSKQSAFPFADLPPFPAPDTPPCISKSSCNRTGYIVESIAGKPFASVLNQRILEPLKLGKTSLLLTEDPSPRVLPADTNSHGWMQGGAETAAISMLSTVTDLAVAGKSILAATLLSRAQTNRWLKPVAHTSNPANSVGYPWVIYSAGDYPDTPIIDVYTTLSTVGLYSSYIGLVPDFNVGFTILATDSNTSPDLNPHTGVIGDNLLPALTKIAAIQASTNFGGLYSSHIANSSITVSADSSPGLVIDTWISNGTDFRATLAALNGVEEVDALSMRLYPAHLISKRTPISRQAFRAVFQDKNEFADYGTPTCVTWLSVDSLKYGGASLDQLIFEVDTNGKALDVEIPALQITLEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D089</accession>
    <name>D4D089_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter, OPT family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000024">
        <property type="protein sequence ID" value="EFE44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025345.1">
        <property type="nucleotide sequence ID" value="XM_003025299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D089"/>
    <dbReference type="GeneID" id="9582956"/>
    <dbReference type="KEGG" id="tve:TRV_00484"/>
    <dbReference type="HOGENOM" id="CLU_010539_2_0_1"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="80678" checksum="B737F6C381AE227D" modified="2010-05-18" version="1">MEAGGSSTRGGEDTLETLETQVEEDDVPPTTYAQSFTPRSLFVGLAIGALITFSNIYFGLQTGWISVMTMPSSLIGFAVFRSLSRHLSFPFTPVENVLIQTVAGAVGTMPLGCGFVGVIPALEYLLRPGPDGPMDGSDGGDGEGGPLKLASWKLIVWSLGVCLFGVIFAVPLRKEVIVREKLKFPSGTATALMINVLHGATKPVDKGKGTTGRLNHSAGSPAETERLLTSNDIASVTLEHLEADRRRKHEWKAKIRMLLLAFGVSAIYTLLSYFAPVLRNLPVFGLPLANQWLWTLNPSPAYIGQGIIMGPSTSLHMLLGAVIGWAILSPLAKHNGWAPGPVNNWETGSKGWIVWVSLAIMLADSIINLAWLAIRPLVNQGPGFVVRLQYEVRRKRFWTGLFSGSTSSSHGYTAIHAREGRDLKGEDYDAPPSELISNRTVAILLPLALILNVVCMRIAFGDIISPFLSIAATLLALLLSIMGVRALGETDLNPVSGISKLTQLIFAAATPASHHTRRSAIVANLLAGAVSESGALQAGDMMQDLKTGHLLGASPKAQFYGQAIGSVVGAIISVGVYKLYVNVYPVPGPMFEVPTGYVWIFTARLVTGQGLPEMAWPAAGIACVIFTITTILRIVGTVSGPAGSKGPVFAPWRAWVPGGIAVAVGMYNVPSFTLARAIGGIIALIWQYRSKVIRDRLALSKAQSASSPGGEEQEASKPLDNDEDSTSSTIVILASGLILGEGIVSILNLILASAKVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0A7</accession>
    <name>D4D0A7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025322.1">
        <property type="nucleotide sequence ID" value="XM_003025276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0A7"/>
    <dbReference type="GeneID" id="9582928"/>
    <dbReference type="KEGG" id="tve:TRV_00502"/>
    <dbReference type="HOGENOM" id="CLU_097257_0_0_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27409" checksum="7127C41FED50A929" modified="2010-05-18" version="1">MNSTRSQLLRLCGIPFSHSAFRPVTSSIPSLVRHAQPLATKTIGSIASSNLLSSLPRSSPFSTSTSTQSQPPPSDAASTTTPTSTTTLPPGVSRGFGTVISAGRMQRTVRVEQIRTKFDNSLQKRFLVKKVHLVSDPRDSLREGDKIEFWSGRRVSEHVRHVVERIIVPFGTPIEDRPPVMTYAERKEEELNARKNRRLRRLERMANGQPVDIEVTGELRMGKLKERVMKRLEAEKERQKQSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0P5</accession>
    <name>D4D0P5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="2 7">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 7"/>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025185.1">
        <property type="nucleotide sequence ID" value="XM_003025139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0P5"/>
    <dbReference type="GeneID" id="9580678"/>
    <dbReference type="KEGG" id="tve:TRV_00640"/>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="9">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="9">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="505" mass="58252" checksum="055DC27FF1D50068" modified="2010-05-18" version="1">MVQPGDDGQKLTTLSTFNPQFTYPLFGDEESIFGYKKLNIKLRFAAHDLQSHVQISYNEKFKQVEDIKAADLLGILKPCLPEVSFSTIDEFKKRINEEDTANFTPPGKLVHSYSRDDKDYEIWAGSLADPEVRKTLDRIQIFVSFFIEGGTPIETDDFDWTLERWIIYFVYEKQKKPSSPKASRYSFAGYATTYRWYFFHPKSSNAAKLAYEAQKTEAFDSFPVSKIPARLRIAQFLIIKPHQHAGHGSQLYRTIQKACLEDPTIFELTIEDPNESFDALRDSNDYHTLKPEFSKHNITINANPIPNTTPGSSSSQPPKHPRVMPTSLLIPTKTLDDLRQEFKIAPTQFAHLVEMYLLSQIPQSHRGAENVNMTRLTTQKSRLQNEHDRRYYWWRMLVKQRLYKRHRDMLIQIDKDERVVKLDETLQNVEEGYDVLLKAFDERASKVSGNGKGKDREADDNEDGNEASASATKKRSKRKFTVEDDDDEMEDAPSAKNRGGKKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0U9</accession>
    <name>D4D0U9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">La domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000046">
        <property type="protein sequence ID" value="EFE44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025134.1">
        <property type="nucleotide sequence ID" value="XM_003025088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0U9"/>
    <dbReference type="GeneID" id="9580627"/>
    <dbReference type="KEGG" id="tve:TRV_00695"/>
    <dbReference type="HOGENOM" id="CLU_005100_0_1_1"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="688"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="903" mass="97251" checksum="27DF52D0284FEA93" modified="2010-05-18" version="1">MAASSVSAKKSTPEMPVFSYAQAAKGLASDSNKQTPAPPSVEETTATATTTANTSTTTMVDADDAGKAVSASPSLGLSASTASTLVKEDDLSTTTPNGTTTATASESEWEKQSQASTAADNKDKSAGSASSTAPLADDDKPKSEASWENTTTTTTNTQKEQKEQKEQKELKAAPPPAVNVWQQRQEALEAKAKANALKPAATTTATSTSTTTTTPTTNTTTTKSTSTQTSSGDVRPEHYKGGSRKKADPATSDPRDKKKASDGSRKSARPARQDGESLPPVNDASSWPTPQTAQGEDLRKAQDQADKPERPEKEKPAGSRTHGKEKWMPVPYVPTAVFNTPLPPAARRGGRSGGPRGGAREGGSRGGAHAGGDRGAATNTSASSKPSSAGDREKGDATESAHKSTTTAADASLKNGDSAAPAEATKDNKPAQNSINTVNATSSDPTSSSQSPTRPHHSKPYHKSHENSSSSYKNTHADHQHASRQANSDSHAGGHSRYANHDRRFDMGARSGEFFKDYQPRGDKDFSKDREYSREYTRESRSERGGRGGYRGGRGGHSNYNNNNNTNNTNNNTTAYTTQTSSASASSSYHSAPIPQHPFPSSKSYNNFSDRHRIQPSANGTQQQQQQQQQQPHSSTATNTRMNMRSPSMPNPGMFPAPYPIQTDMNILYPYPHALPAGPMTAMSYQPYMEHYSLMGTISMQLEYYFSVDNLCKDLFLRRHMDSQGYVLLSVIASFKRIKSLTEDMELLRFVCRQLRNVEYRPGEDGVDRLRKREEWAQWVLSMDERDPSARNEGPSSATAQEYIPQQHQQQQVHMNGHAHAHAHAHVHGNGTYVNTNYVPADNHSAEEPKRPAKLSSAAPEFSPLSANGHAPSFEQGTSTPVDAQGHGQVQPADGSNFVAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V2</accession>
    <name>D4D0V2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025119.1">
        <property type="nucleotide sequence ID" value="XM_003025073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V2"/>
    <dbReference type="GeneID" id="9580612"/>
    <dbReference type="KEGG" id="tve:TRV_00698"/>
    <dbReference type="HOGENOM" id="CLU_032508_0_0_1"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="49225" checksum="4912FF5C0EFD23AF" modified="2010-05-18" version="1">MTRYPTAQIWTRGIRFIQVSRTLSPTDPEHSVSPTNWSKKRHRNPNSSRKRALSEAGSNVAGSEQSTTYYTWSKTNSKISSSDPKEPCQTGGISRQLRRSISAGSSQMNSKVQDMLFHNAYVSNTFEHTETHHSPKSYSLEGLLRKAAETSPIPYQTNIPPSSHPPSAACLQAQPHHNQHSNSRETLTQEPSWRQCYRSGRASKGGANILLSPRFPEELLPSSKDTEHKRRGSLGKINRPWPSVEDIPRPAIYGFPSGCDYTSYLTIPRLRQYPSRRGSYPSDCEAAVDNVQRSLNERSQKRLTCQSSNLTLAPGPSTPLKVPSLQLPSYSSTFSRQYRLYGSPPPFNLPKNPPSETIDLDTLSSRRDSSIHLLDGETQSLRTPSEPDRDFLCTPPSRLRTLSQSQSTDAATPGDQNIQTDIEDPNFEPSHFWKPNKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D121</accession>
    <name>D4D121_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025109.1">
        <property type="nucleotide sequence ID" value="XM_003025063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D121"/>
    <dbReference type="GeneID" id="9580601"/>
    <dbReference type="KEGG" id="tve:TRV_00767"/>
    <dbReference type="HOGENOM" id="CLU_2484949_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055155" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9820" checksum="5A5393C81BB9838B" modified="2010-05-18" version="1">MNIFVESFCFFLPLLPSLTRPEDVVEGGQVEIDIMTTGVVPPHLAAAPYWSVIDAMTLCQMRSRFELPTIAWNCMKRGFYLPPTPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D132</accession>
    <name>D4D132_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025041.1">
        <property type="nucleotide sequence ID" value="XM_003024995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D132"/>
    <dbReference type="GeneID" id="9580533"/>
    <dbReference type="KEGG" id="tve:TRV_00779"/>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="88355" checksum="5F55347CB4BA760D" modified="2010-05-18" version="1">MDPTTSVMGAERSAPKKRRHRAPRKKRNRRPSFAPAGDNSHFQSPLSRVDTQPNEEHEDTKDASLTETRPRPFYNLGRSGGGNLSETSLESEALLDHRHETLPEDDFAITDDRSPLLNSSAQNGGALRGYGSDLRSPYSMPAGMGSPTSRRSPQNSYTPDAFLASRQGYDVNNPPSMPGSPKIMPNNMGYDETVITGPEFVRQQSPEALSCHSLPMDAVVNVDTDSRRPGLQSRHGSMSRSPADLQRRRTLTLPVEEDVCFPASGLSDLGEEDLQSHIPTGGDTRERRRRSRRVWPDLSVLDEWSQHEKEARSGGTRSKRIDEPVLIGGRLRTRNLAWKQDEEEEAPYRFTYFNEDFQSTLHSQTLSELEQPGQTFRDLFIPEPPLLEDDSSDEEDDSPPHSGTTSRDKHPSISTNANHNTNNLPDLLSDNPNSTSPQPTNGNSRIPSPKKEPRYGPRPTFWLDVLSPTDSEMRIIAKAFGIHALTAEDIMMQEAREKVELFRNYYFINYRTFEQDVNSPDFLEPVNMYVVVFREGLLSFHFSRTPHPANVRRRIRQLKDYLILSADWISYAIIDDITDVFGPLIHAIEEEVDEIDDKILRLHSDDKEMGSDQNNEKTAALEESGSGTNMLRQVGACRKKVMGLYRLLGNKADVIKGFAKRCNEYWEVAPKSEIGLYLGDIQDHILTMTSNLTHYETLLSRVHSNYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIICGMWGMNVKVPGQDVESLNWFWSSMFPEHLILVHQSPIGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D190</accession>
    <name>D4D190_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025033.1">
        <property type="nucleotide sequence ID" value="XM_003024987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D190"/>
    <dbReference type="GeneID" id="9580525"/>
    <dbReference type="KEGG" id="tve:TRV_00838"/>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="248" mass="28050" checksum="D47CE292D6B4076F" modified="2010-05-18" version="1">MTLSVHPATAEDIPRILDIQSTALKQSGFFRACGEISNPGGFQDHDEKYPEPIRRELQTKRLIYQMENDPGFHLLKCVDDDTGEILAFAKWNVYVGGPEALKRWREQMKTGEDMFVPEGANVEGYRYCMGKLFDNRKLFFGEEGRENCVLALLATDPAHERRGAGTLLVNWGCDLADKHGAETYLEASQRGYPVYERRGFEVIPTTEKQSAKLHFDASKYTGRGLGEGGQGDWARLTIMVRKPRPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D297</accession>
    <name>D4D297_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024631.1">
        <property type="nucleotide sequence ID" value="XM_003024585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D297"/>
    <dbReference type="GeneID" id="9579958"/>
    <dbReference type="KEGG" id="tve:TRV_01200"/>
    <dbReference type="HOGENOM" id="CLU_039096_0_0_1"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="377" mass="42210" checksum="74611BD2614D80C2" modified="2010-05-18" version="1">MDLESTEIKTRVERFESAMEKVYGNHRDVSDPSAWTPPPAPGGHRGRYLWTDAFGVVNFLTLYKMHSDLNAENGYPERYLTFAERLVETVHDVLGRTRDGTSRLPGATDSEPLAGGLRIGKVHESGSDGDGQYHHYLTQWMFALNRLSMATGNPTYNRQAYSLGKAIHPHFFVGIGTHNPRMVWKVAMDLSHTLVSSEGNLDPLDGYITFSLVQASAKKFGDGEVFEEEISNYKKVSDRRGQHHPSPDFLDLGMTLVSVQWFYNEDWAVTLASRCCNILKSLFDEGYHLKFGSSRLAFREFGACLGVECFRATVGPDGELYDYFKEMSDAMIDQYNDGDIQTPDDLKPITRVMFASALIPGAFQAGFFGPEPIKIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2I8</accession>
    <name>D4D2I8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01293</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024581.1">
        <property type="nucleotide sequence ID" value="XM_003024535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2I8"/>
    <dbReference type="GeneID" id="9579905"/>
    <dbReference type="KEGG" id="tve:TRV_01293"/>
    <dbReference type="HOGENOM" id="CLU_013985_0_1_1"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="194" mass="22329" checksum="C8E92D374A4DF3DC" modified="2010-05-18" version="1">MADAPSQFRYVQYEAAKENEYVPAMRQLISQDLSEPYSIYVYRYFLYEWGDLCFMAMDEKDKLVGVVVSKLEPHRGGPLRGYIAMLAVQEEHRGKGIATKLVRLAMDAMIERDADEIVLETEITNSPAMKLYERLGFLRSKQLHRYYLNGNSAFRFVLYLKEDVGMIPTSDPYHGHPDGLPLHENGEHPGHHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2S3</accession>
    <name>D4D2S3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RAS small monomeric GTPase Rab6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024416.1">
        <property type="nucleotide sequence ID" value="XM_003024370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2S3"/>
    <dbReference type="GeneID" id="9579638"/>
    <dbReference type="KEGG" id="tve:TRV_01379"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19790" checksum="9670051DAC97FA00" modified="2010-05-18" version="1">MHYKLQGRPQADGETVGKTSLITRFMYDSFDNTYQATIGIDFLSKLWDTAGQERFRSLIPSYIQNSNVAVVVYDISNAKSFQNTRKWVDDVRDERGNDVIIALVGNKTDLNDKREVTTEQGEEEAKKNGLMFIETSAKLGHNVKNLFKKIAQALPGMEGETPNSDNQSTLSSCLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V2</accession>
    <name>D4D2V2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible replication factor-a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024445.1">
        <property type="nucleotide sequence ID" value="XM_003024399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V2"/>
    <dbReference type="GeneID" id="9579667"/>
    <dbReference type="KEGG" id="tve:TRV_01408"/>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="284" mass="31191" checksum="592A33E87ACF889F" modified="2010-05-18" version="1">MGEFHSIRRLFRELTNAYRLRTYSGESRSVRPVTIKQLNDATQAFPEAPFKIDNADINQVCFVGQVRNVNKLATHITYKLDDGTGETDVKYFIPPEEKEAFDELEAMDVMAMDGAGSNAGPAAVTNKSGRPRAHQITTNGYAKVFANVKTFNDRRQVNAVLIRPITNINEYHVHFLEATAVHLYFTKGPPPKAGGASGTGAGTGGGAMDMGGSNLSLPRISPMARKLYNALSNSRQTNEGMHVNVLAPIMQVNVNEVYKAAEELLGLSVIYHTVDEDTWKILDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3M2</accession>
    <name>D4D3M2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024183.1">
        <property type="nucleotide sequence ID" value="XM_003024137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3M2"/>
    <dbReference type="GeneID" id="9579221"/>
    <dbReference type="KEGG" id="tve:TRV_01682"/>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="2">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="508" mass="55970" checksum="E13F80D2D8ACF5B4" modified="2010-05-18" version="1">MAIIAQFQGANIWRYSEYLIARSLAFSETKTDYVRNGQGRLKSLTVSKGLLRETEIVQKQIKALLKCDVRIYHLAFLLSDEPDNEITLTGFRLVTLDLLTLYSVMNEGVINVLGWWLSAPFGIALTDDVVAFLRVARQYEHATRLEIPNLKHASTDLAKLLEDDLHDPDFAIRRKEYREQKFGKSKGESSSASKAAKAQPSSKANNSTSSKDVPSSGTKAPAADLIDFFGSIEENQPPANQQLPPQQPQQQNMPMQFQQTGFQQQPVPAEFLQNQTGFAPNPMGQNINPFGQYDTQMQQQQQQQPPAAQPLQASHTGAGFGGYTPQPFQSPSPLSAIPQNGAVPFQRPMTAGATPRANNPFRQSMLPTADNLSSPQLQSPSTLAMKRQSTNPFAKQPPAIPPQYQIPNPNQYPMPSSSPPPSQQQPQPLQPQRIGTNPFARPQPQQSQEALPAQRLQPNPTGSTNPFRQSAFINQATGQGWQNVPQGTMGGLEKLETIPVFPRPGQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R0</accession>
    <name>D4D3R0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024122.1">
        <property type="nucleotide sequence ID" value="XM_003024076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R0"/>
    <dbReference type="GeneID" id="9577118"/>
    <dbReference type="KEGG" id="tve:TRV_01721"/>
    <dbReference type="HOGENOM" id="CLU_070886_0_0_1"/>
    <dbReference type="OrthoDB" id="4188015at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="328" mass="37085" checksum="E61DA9C78994E724" modified="2010-05-18" version="1">MGHSITWEYSEESEAEEMVSRCSYCGRFCNKRAIHGKTGLCYPCRETLRKEGDKRALETDSDTESASSGRGAEECEPVKGHPAATAEAEDDSQSAKSEEGTARSNVCSRCWAAEATGTLYNSPVCDDCYHLAQANREWMKGTKRKRCEHRRVVDATDPEAHCRKRGRKRKCEEISEDKKESESNNAPTRREEEQGVLIDILFFFFISFYPAEIIVVDDPAEEPGCSDESMNHAIKESLDTVYKRELLKLEAIANEKVDEANKALDAVRDHLRSWLEHVRRGNSLGKQQLPEQQPKGPEQPEKLDPLEQQDQPPQSLHPPEPTAQEECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S4</accession>
    <name>D4D3S4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025847.1">
        <property type="nucleotide sequence ID" value="XM_003025801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S4"/>
    <dbReference type="GeneID" id="9577105"/>
    <dbReference type="KEGG" id="tve:TRV_01736"/>
    <dbReference type="HOGENOM" id="CLU_135765_1_0_1"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="103" mass="11612" checksum="66539AF5B17F0DDD" modified="2010-05-18" version="1">MAGNSNVGTRTIYESNEQRNVTRSEVENARRNRDNPPDSNRRGSAHGKEQKSRGKHSPTDDELAKIDPTAPARMHGHKPSRGAQVDAELKREDEERIRQKQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S8</accession>
    <name>D4D3S8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_01740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025851.1">
        <property type="nucleotide sequence ID" value="XM_003025805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S8"/>
    <dbReference type="GeneID" id="9577102"/>
    <dbReference type="KEGG" id="tve:TRV_01740"/>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="462"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="735" mass="81514" checksum="00F333B7EDE27A01" modified="2010-05-18" version="1">MKRDLGALFQAANLENKKRHKKHPNVKRFSPLPNTQKVDNASEPASQPQEELASQWPVEQRQREATWLLSCLPPSFDRLFHHPPPTCSIMAGNAARSRSGSGASHYGTGDDEGSVLGTGLTSRQLEAFGRKVTTTASHLMSTTTDPTANVHYQAALSGIQRELRRPGAQRRMFAFAQTTPTELVRSKFSTSEIQYRALSSLPDDLLQHLPEDTSTYSLFQGFQASIHDADNEHRKSHRRRSSHGQKRLEDVDRNTGALPPTIGHLKRERDSLNHRLEMMGVRKNMCSAEIHEIDNKIMNLNKMRKIVLDRLAGLEMDEADLEHEYNRLEDMEDALDESVAAATAATPKTGDIPSSPIGDGEGDSSFMSESIYEKIPSPKAWRHKTSNIFFCSEAYIVDIEKRSTPVLHEHFEPGSLIRELQAHNDMIAALDFDVPFGTMVSAALDDTVRVWDLNLGRCMGFLEGHHASVRCLQVEDSIVATGSMDASIRLWDLSRAKYEPRDHRADRDEEDDEDALGFEDPAAAPPTPPPSSMDECPLFSLEAHVDEVTALHLRGDTLISGSADKTLRQWDLVKGRCVQTLDVLWAAAQASSTMAAGDSAAWRPTGRLPDASADFVGALQCFDAALACGTADGMVRLWDLRSGQIWDLRTGTIHDAYAYDRPVTSMMFDTRRIVAAAGEDVVKVYDKTDGRHWDCGSGVASEDDGRAHSIVERVRIKDGYLTEGRKDGTIGIWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U5</accession>
    <name>D4D3U5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fermentation associated protein (Csf1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024088.1">
        <property type="nucleotide sequence ID" value="XM_003024042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577076"/>
    <dbReference type="KEGG" id="tve:TRV_01757"/>
    <dbReference type="HOGENOM" id="CLU_000126_1_0_1"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Csf1 N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="2">
        <location>
            <begin position="787"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="3">
        <location>
            <begin position="2447"/>
            <end position="3094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2105"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2313"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2405"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2108"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2405"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3095" mass="344760" checksum="C8DB69E95997D56C" modified="2010-05-18" version="1">MAKMRPFTPELPVDTCHVKSKPKPPECEAAGGASGEDENGGNHAANGKETPARIEITLNGLEWFVYNRSPAYDSILAGFGLVPPPDGASASSVAENGENVQHEDSSPKEENVDEVAASSPSDPLTPSSRKEINSQKRRTSSSTRNSSIPQHRENSTGPRIFSFFPISMNCYKGALALGNENTKTILTLTFDKAVGKIDAESSGPLDIYKQIFEYDLSHPVIHMKPNPDYRQSQLAAVHEMETPEEEESRNRGYVHSLHRRYRDHRHRVWASVRDLIPYFQRSVESFHPRHDERDRPVSRAVHQDGWLGLTRYLDEEEQDDYEGWNSIEYGRFSTLLDSPSMYFRYYWDIGGPVAISSAKPDPPDRLTPHNINGAEAPEWGMDLTIRGGLLNYGPWADRERINLQSVFVPNSYRDSHVTPILKPGETRQSTAFVLNILIEETTILRIPTREASKDWQWRGRADRSRGASRMKKKDKDRSRGNEADNPGTQGPDIRPFGWLSLRAGPGSTIVYSMAMFASRHGYCNKVDIDLRQTKMTTSVNHGMLWQSDRQLISCDLSNPLRWNSLHNWSVDVESTNMELFLLWDHLILLTDLISDWTLGPFQEYYTFVPIKYQLSFAFLDFKLMVNVNDLNIINNPSDFDDNSFLIIEGEILTARVEIPVIHHRASRNIATFDIQGSNGDLKLSTPLWNTQRTFLDDRPVGGLDTLKIDGSYTWHSITSPKVTDVAIINLSGTAPYLYLYGFILKQFLDVNENYFGRTIHFKTFDEHRAAANSTATQGIYGSNPAPHTNGLDVILHIAAEDIKVLLPTGLYDRHESLALKATSLDLDVRFTNYYMDFHCSLSPLEVSVLSEKPGASVVRSGPQLYINGLGIFGHRLFGLPPTEPTYACNWDFQVGSIVGECSPSFIKSAKSAFESLAFSFDDDENALPPIQTGVYDVTFLRANVKSIKVWILAEKSAFLFSTGTIDVEFNDRCGLKMSLFVDVTVPDIVLAVVDRTSVTPGSASQSPAKTYACFRTAVKLSTLGKREDFDYYRSLQQNHIRRHDSRTHRTPWLVFNELELAPGENLHPSFIPPTMPVPSMPEPIQSPADSKASQAPHHSPLNDVPDATTIPLTSSLNPTPDQYVSQGRRAGHCSTTWAMPKFSFYHVQLDETNVPPIPSNSEVFIGRNQALNAGFGRSYADEFLAGAQACINCSMAPGLSGFASIEAVRAVACLLDSLQPRKPLEILDAFQAKVTSAALAAQKSAIKRIKKIFSLNIELPSCRVRFFNTLLKSGRPTGPFRDQFHLDISYIRALIREKVSSLDAADFAKPKTSLTAHIAMRSLMATVREENVETHSDVKLCVCKVFDTTFWFFGSKDIRSRLQVQNINLMSSNESVTRIEPVLNRTMKLVESLSATFQRIFEAHEDRLLYLIHYLTKAGVDMPEPHFMTLLSDALRATKPHLRLEDAWKIISRIRNIYKSITPEQRGQLEKECQKSDVSYPEDAKDAILSVFETWRAWELAPIEKNLIIKALWGEVATTDETAGPLKAIDAAIYLGSVHLSMDQTPRHNGFRVENMSTTIRFGAKSQDAWSSAKDGLLVIQNHCSNAYLQLNWELCQLIEKILESNDNLGSKATTLQRKETSKSRYEVKPEHEIQYETHVLLIADKGSVWIDGINLEIELVGRGMKASAIHLPSTTLGKETISAMLASKLSSARVISHSSPLMEWEFHNPNIFVSRQSQKRNALLEHDWKCAATCRQLRYELTENPLELIHVADRVVEDEVRQILKMVSSLSDVKSEEGPTSASSGEEIHYFHVATFLDDYQIRISLLPSVAYTIEGDVARLSVTPLGRMKFEVDYDIKNSIHKIYSNKDGSLRTLCSTAIPPINGRVRLDMTTNPIIVDADTTVEVLYLDVSAVQNLLGALNGPEISHFIDDLSHDGKALKSHFEQVLMNGRATQPKEKAKKKGPVYQVRLTLAGINTHASSPGLRTRDHTADMNIEFKSVQVHVENSPIQGVRNARPEFNIIVAQISVNVQRTSMHDSFSYGKVAFGAQFSGSFKDLPDGKTMQLFHLKSSGLEIDMSAETASLVLDIVAHLQEGIKTIDLSQDIARLRKSRRLSFLRRKHRKITHTATSPAEPSAGGDNSQGTPDFLNATYSVELSNIQISWLVLENTSPGKNRNPSIRHDTGAEDLVFSIRKVELTTKEINAARLRIQQMQLQMVPVTYDKKKRSQNSALLPEAVFNVSFVSVKSKWKLALNAAGKALDLQATSDFIIPASHLQKSMASAVERVREAKSLWTTEFRENPKVGKESLGFKQLDSVFIDANFDGAIVTLQERRDAGDSTPRPPSNRSSIGSTDFRYGQAWTGDAVSKATLRAPGVALKIRFEGSEADTPILEAEMKVEASSNVLHPSVMPLLTRISSSIRDVVGREEKRDSQVTKAGAEEPSAGKDETDKPAVGGEETEKPPQDKSMDPTTILGSCKLSIGLWIRKQEFTLSCQPIARVEASAGFEDVNITVNTVQSEEQRRFFAVLIAFNKLRASVKHVYSNDPTASFNVDSIVVSMMNSKHVSSSSGISAILKVSPTRLFMNSRQAQDFLLFREIWKPPSDHFKRPVQTQEPSPEVQAYMVQRYQQMAATGAFPWNSTLAIDSLDIQLDLGQTIGKAEFSIKNLWLSSKKTSDWEQNLCIGFEAVSIKNEGRLTGFVELSKFRVRTSIEWPGGVISAGHTPLIQAAVGIGKLQADVSFEYLPVIVADVTSFEFFMYNVREDEGKSNDRLVSMLEGDKLHVFCTTITASQALGLYQTFQRLIGEKRKAFQESLKEVEDALHRTKLSLGVAPQKPVTRPTIKDDKDAMNLPISLQTTVVVKLHTVTVGAFPNTFRDAQIFQIEALGAEARFSVGIQGGKIHTGLGLTLGELRVALSSVGGGSVPADANDLTVDQIVSRATSARGGIILKVPRVLSLMETWQQATSNHIEYRFRSSFEGKVDVGWNYSRIAFIRGMWSTHSRALAARLGKPLPQAAVQITGGPKGEGEEGEYNGQEKITAVVNVPQSRYTYTAISPPTIETPQLRDMGEATPPLEWIGLQRDRLPNLMHQIIIVTLMEVAKDVEDAYSNILGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D451</accession>
    <name>D4D451_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024003.1">
        <property type="nucleotide sequence ID" value="XM_003023957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D451"/>
    <dbReference type="GeneID" id="9582696"/>
    <dbReference type="KEGG" id="tve:TRV_01865"/>
    <dbReference type="HOGENOM" id="CLU_027370_1_0_1"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="426" mass="46976" checksum="EB36AA320C570763" modified="2010-05-18" version="1">MEKTGYISSTETKNITESLEISTAALRKLENTQDSSTLRTCPFDHGKRRTSMEHDFTTNGIKGALGCPFKNSNSSADAGEETNINGESCQNDDGDPIKLEKIGEGVPSTVHSSSARCPIRYLGDHSPEELAEYFLNHKHEIPRSHSVCIRRYQNNPQTSRKIDAKYGNVINMVKGLGEYHQPYLSVPHEIDETRQGDTDPVAQPSSVERVEKWAEDVSNKSPPAGSTSPEEIETAAPAPDEHQGLTNGDYDRQGHFERPLRDVRVGESPSRPWGIHVPPEQPAVDHTFTHPPESHYEKPEVVDEEPTMLLPSQGRLSPLGQASTFGNDAEAEAEANATLDAAVDEDEQPGPEIDEASSHRRIHSHHQMPHTNTQTNTYSVPRSNLSPEAPITHIPNPQPRMVFNGPVFFGYTAEAAAMLLEKMGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4C9</accession>
    <name>D4D4C9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">TRV_01944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023894.1">
        <property type="nucleotide sequence ID" value="XM_003023848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4C9"/>
    <dbReference type="GeneID" id="9582494"/>
    <dbReference type="KEGG" id="tve:TRV_01944"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="305"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="469" mass="53853" checksum="2C3828FF6ABF1C28" modified="2010-05-18" version="1">MFRPPINRAMRVLDRSFFKKTIPLAAATVFEARNLGRIKTELAKSNDILNAPRLPAIRYVQNPTTEEEKNKMCILLKEQIQANDAATWSPTIRELVEAKSVELKPYDLHLDYDYWLYHDILSSILPEEHLEETPAGFNQVGHVETGYTKLRENIAHLNLREQYLPYKHLIAEVIRDKNSTVRTVINKVDDVGANSEYRTFAYEHLVGDEDMNVVQHEQGCEFAFDYSKVYWNSRLGNEHTYLVGRFKEGEAVCDVMAGVGPFALPAGKKRVFVYANDLNPHGYEKLKEGAARNKVREFVQPFNMDGREFIRHASQELCVNGPRPVKIYPKVKRTEAAEKKAVPPQVYKCPPTFDHYVMNLPASAIEFLDAFIGVYAGKESMFEPHTQRKRPFVHVYCFSTNSDDNAVEFADICNRISERIQYKITPDDMIGGTGNQDLELEIRDIRLVSPNKRMFCASFRLPAEVMFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4E7</accession>
    <name>D4D4E7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023912.1">
        <property type="nucleotide sequence ID" value="XM_003023866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4E7"/>
    <dbReference type="GeneID" id="9582524"/>
    <dbReference type="KEGG" id="tve:TRV_01963"/>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="591" mass="65091" checksum="A8A938C71EA3429B" modified="2010-05-18" version="1">MAPLSILDLVSALPSDDTWGPAVTTEKTLDGVPYAPFSKGDKLGRMADWSSEGKDGRDGRGGRQAYNRNYRDQQVYGAGTGSLFAVQVAEDESSFSVVDNTRTSVKSRGFGRGGGTIFRGRGRGGPQRGRGGFQRVGGGRGGQGGDRYFDSRGGRGGRGGGRRFGWKDYDKPQRNRDSSIAIRPEWTVLEEIDFNRLAKLNLETPEGQDIDTYGFLHYYDRSYDKAPVKGAEKKLQSLDRAAYNVTTSADPVIQELSEKTDATVFATSDILSMLMCAPRSVYSWDIVIVKQGDKIYFDKRDNASIDLVTVNENATDAPLEVSEAQSGTKHDPINTPGALALEATIINHNFTLQTVVESDTSKVDYPNSNPFYNPSEETEPLASKAYKYRRFDLSVGGEEEPVNMVVRTEVDAVIKNVSGDDHLVTLRALNEFDHRAPGAGGALDWRNKLSSQRGAVVATEMKNNNCKLARWTTQALLAKTDILKLGFIARANPRSASAHIILGVMGYKPREFAGQMNLNINNGWGIVRTIVDLIRSHDNEEEGDEETVKKYILVKDPNKPVLRLYGVPSNTFEEDEDMGQGRDGKIDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4G7</accession>
    <name>D4D4G7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023862.1">
        <property type="nucleotide sequence ID" value="XM_003023816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4G7"/>
    <dbReference type="GeneID" id="9582486"/>
    <dbReference type="KEGG" id="tve:TRV_01983"/>
    <dbReference type="HOGENOM" id="CLU_1705540_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16898" checksum="14338375D3843768" modified="2010-05-18" version="1">MSPGLQTASGLFLVFEVGDVKRRVRQKKVLPLGPKRTSSTPSFRAKQKRSYQFEATIPTATLEFFHQPQPTPSTHPLTNGQAQAAMGGASREGGKAKPLKAPKKEKRELDDEDLAFREKQKADAKAKKELQELAKGKKGPMNTGQQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V3</accession>
    <name>D4D4V3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-protein ligase Sel1/Ubx2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023733.1">
        <property type="nucleotide sequence ID" value="XM_003023687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V3"/>
    <dbReference type="GeneID" id="9582268"/>
    <dbReference type="KEGG" id="tve:TRV_02120"/>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="93830" checksum="A01FB2D7B439D878" modified="2010-05-18" version="1">MALFGRPRAITAGARNLREDLTNRESNPTDLPLPGSLDVENPVARARGNNAREYSIDQPVVDTALNILRKIKVPTKKYERPSGIFGHASYYGRELFYLLFMNAPSSDQLSSSRFTKKNGKLVEAVRLLEGAARKNNSDATFLLAEMNFYGNYTHPRDFSKAFRYYDALATLTGNSTAQYMLGFMYATGIGGVVERDQGKALLYHTFAARGGNTRSQMTLAYRRYIGIGAAPDCDQAVYWYKKVADKAIAWYRSGPPGGINWRREAFRWADEEGGVYGEGASVSSAGYNAMRDVHSSADASLDDVLEYLDLMAKKGDTKATFGLGKLYYEGSRQLERSYKKAMMYFVVVARKYWTKDGSINPSHPPGIDKIAAQSAAHIGLMFLRGEGTEQNFQKAKVWFTRGRANGDAMCQHYLGLMYLHGYGVEQDVMKAASYFKAAAEQDNYYSKTRLGALFLDQGDVVTASIYFEAAARHGGMEALYYLAGIADRGLGGQRHCGVATAYYKIVSEKAEGIHSAFAEANDAYEIGDKELALIISTMAAEQGYESAQANVAYLLDEKRSVLSLDPILPWVRGGRSSLLRNAALGFIYWARSAKQANIDSMVKLGDYYFEGYGTKKDVSRALTCYHSAAEGHSAQAFWNLGWMYENGLHVEQDFPMAKRYYDLALETNQEAYFPVTLSLLRLRARNFWNKVIRGKANTINAEPDVNTPRTFKEWISHFINYNEEEEAYQRALRQQAAADPDAILDEAGHAHAQDQDLNYYDEEFDDGILESLIIIGLVATLVLLLHFRQQRAARRAQEANNANNQQQNQGADGAGNAAEDRGFFPRPDDPNFAAWVAGGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Z7</accession>
    <name>D4D4Z7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02166</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023658.1">
        <property type="nucleotide sequence ID" value="XM_003023612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Z7"/>
    <dbReference type="GeneID" id="9582205"/>
    <dbReference type="KEGG" id="tve:TRV_02166"/>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="566"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE43040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="679" mass="75811" checksum="027CE4E0B1CB4F6E" modified="2010-05-18" version="1">MKRKADSEAQSPAENGDQLAKKRAVSAQSVVPSFADGLLDKDTLEKYKAAYAKSGPYKHGVISPLFNQELLRAVRSEIQEHISFTEKETDIYKIYQSGDLANLDGLDDESLSRLPSLLKLRNALYSEPFREYLSEVTGAGKLSGSKTDMAVNVYTGGCHLLCHDDVIGSRRVSYILYLTDPDVPWKPEWGGALRLFPTTTETNADGEEVKIPKPDHTVSIPPAFNQLSFFAVQPGESFHDVEEVYHMETKGSEKEIKSRVRMAISGWFHIPQEGEDGYEEGLAEKLAERSSLQQLQGEGDEFDRPQPQFVPYKTVEEQDTSSKGKEPAKSAGEDDNDDEGFNDKDLDFLLKYIAPSYLTPDVASQLNEIFDNDRIVRLEKFLSDKFTPRLRSYIESQEKDETFPTSAEEIEQKTDWKVSRPPHKHRYLYQQPCLDKTSDGQKEKTPIQELLEDLLPSRAFKKWLSAVTGLDGLLGYNLLARRFRRGEDYTLASGYEGESPRLEFTIGITPTPGWEKEEEDEEEEEAGKADKTKSETNSKAKPENGTAAAAAAAAAAAEQEEELAVGGYEIYMAGDDDDEEEEEAGAATEQTLGSTGSKSKVNKSKADPAIYKSSTNDEDDGILLSMAAGWNRMSIVLRDQGPLKFVKYVSRAAKGDRWDITGEIDVEYDDEEEDEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5G4</accession>
    <name>D4D5G4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023587.1">
        <property type="nucleotide sequence ID" value="XM_003023541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5G4"/>
    <dbReference type="GeneID" id="9577059"/>
    <dbReference type="KEGG" id="tve:TRV_02334"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_3_1"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="87" mass="9477" checksum="0339DC2839DA2802" modified="2010-05-18" version="1">MINIFEVFLPQLLRYPNPSDPLNGDAAAVLLRDPKKYDAKVREYVTKYASKDAADDGGEDTEDDGEMSSVGSYESGGEEPAGEMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5N3</accession>
    <name>D4D5N3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000125">
        <property type="protein sequence ID" value="EFE42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023452.1">
        <property type="nucleotide sequence ID" value="XM_003023406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5N3"/>
    <dbReference type="GeneID" id="9583479"/>
    <dbReference type="KEGG" id="tve:TRV_02406"/>
    <dbReference type="HOGENOM" id="CLU_3368788_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="35" mass="4034" checksum="67A49A3DB3997C4C" modified="2010-05-18" version="1">MPKKMMEKIEKKKRRGGRGRKGQEDGKDIGPKGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T0</accession>
    <name>D4D5T0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023351.1">
        <property type="nucleotide sequence ID" value="XM_003023305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T0"/>
    <dbReference type="GeneID" id="9583371"/>
    <dbReference type="KEGG" id="tve:TRV_02453"/>
    <dbReference type="HOGENOM" id="CLU_055310_1_0_1"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="225"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34102" checksum="54C5F976A96D1E11" modified="2010-05-18" version="1">MSTAAVPPTHIRPPYSLDAAAAGAGGFSDAQGLSNTGCPRCGFEGAYRQLQERNIAQQRRIEELEAQTRLPTEKAALSGMLTVSHRVHNTTKKADHPNLLLLAEKLADYEDGMSSQSQSSQSKPVSAPELRNLDQHPPQQQQSPSPPRQQTRLATLASYLPYGRRTSSNASATQSRQSVSSSQLPQSSSSSSPPSTRAGKNGEHSAMNPLYNGLPQPTSFLQGALNREQALRREAESRLTQANTELEELSAELFMRANEMVANERRERAKLEERVQVLEKRDKEKRTRLERLEKAVERVERVKGLIGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D600</accession>
    <name>D4D600_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAF1 family ribonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023421.1">
        <property type="nucleotide sequence ID" value="XM_003023375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D600"/>
    <dbReference type="GeneID" id="9583441"/>
    <dbReference type="KEGG" id="tve:TRV_02523"/>
    <dbReference type="HOGENOM" id="CLU_022380_0_0_1"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="48138" checksum="87B4AC94ECDDE325" modified="2010-05-18" version="1">MKEEQDAMDRAHKDKDKLLRSLINLDTLAPGHAQFIRQVRHSIREWIEKPAPKDAYLNIPKPAGMTAAHKLPLELDNYQKRLVHQIVQSEYPGYVSIGKKSFIQILPYDKMRENVFLQKKLQRTRCNIASQKGFSWVIEALMGSELSKLDLRLLWRPDGMFTAAEGSKLTKESEALREKLRSGPPVLVGHNLFTDLVNFYKCFIGDLPSRVEDFQQAINELFPLVIDTKYMATTGGVLRDASSALSTLMENLGSRVVPKFGILFHSMHLLLLSPRKLTFCANGIETHPDHSSYTVSTPMHEAGYDSLMTAQIFLKLAVQLYETNEQGKAENTTQQKLVYGHATKFDLLLDMDDEESGASSVGPSEQDSLLEQKVIEGKLLPRLDDDFWSKYINKLRVFGTTEEKINFERGEASLSRIFGGCFCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D672</accession>
    <name>D4D672_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023261.1">
        <property type="nucleotide sequence ID" value="XM_003023215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D672"/>
    <dbReference type="GeneID" id="9583269"/>
    <dbReference type="KEGG" id="tve:TRV_02595"/>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055279" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55748" checksum="28E12EFC0EC45016" modified="2010-05-18" version="1">MQLSLITLCTIGIGATAVQAALAPNSTWPVQSYNSTNIRASVLETTKMGETDPGYIFVTPWNGHRSGHPSIYRDDGQLVWQGPEGTIFGFRPQNLSNNPMLVFWEGDFTGTGYGHGSVNLLNSSYQLVHKVTLTEGYFNTGLDHEVESHIDYHEGIVENDKKALLVAATNITQADLRSVGGPEQGWVIDGLIYDIDIETNKVLFRWSAVEHIDQIPFKLSQSPLLDTGTSEKNPWDFFRVSSTVRYGDDYLISWDYGCSILHIARNGSVAWNLNGITGGDFKMGPNSNFCFQYGLRLGMHTDEKITISMHNNDNSEFSNTNNPTTGLILDLDLQKMEVVGQRRMWNHEHPVVSRDLGSFQYLGTGHCIVHHGQIPLIEEYNKEDELVMQIRYGHDLVDASYRVHRVPWTGMPITKPSVKACRKADKDIVVYVSWNGSTDIESWKVFEVSEGSMPKEIKDEAWTGFETTIQAQSEAKKVLVAAVGGYGDGVESDPVTVDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D695</accession>
    <name>D4D695_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell differentiation protein rcd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023284.1">
        <property type="nucleotide sequence ID" value="XM_003023238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D695"/>
    <dbReference type="GeneID" id="9583304"/>
    <dbReference type="KEGG" id="tve:TRV_02618"/>
    <dbReference type="HOGENOM" id="CLU_039962_0_0_1"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46991" checksum="DFA499B2F3FE98D6" modified="2010-05-18" version="1">MLQSQAPHVFSHQHQYPQADSSWAQQHQQHQQHQQQQHQSHFQSQQPQQHPSLAAQQHAQAQAQAAAAAAAAQHQQQQQHYSRIGMTGGVNSNSQTPGGQDNGNGIAGNIDSGVSEENRKVLVWVAELLDPNRRESALMELSKKREQVPELALIIWHSFGREYPFIRHPRVQPYCAIYYMLTYFQGVMTSLLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHNETRTLFLNAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSDVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDIGLAYICATYERFYAVGTVLSNMVTQLVEQQTVRLLKHVVRCFLRDNNRAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVVDGSNAGSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6A8</accession>
    <name>D4D6A8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000136">
        <property type="protein sequence ID" value="EFE42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023229.1">
        <property type="nucleotide sequence ID" value="XM_003023183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6A8"/>
    <dbReference type="GeneID" id="9583251"/>
    <dbReference type="KEGG" id="tve:TRV_02633"/>
    <dbReference type="HOGENOM" id="CLU_687334_0_0_1"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="433" mass="46826" checksum="158A0DB051B56BE3" modified="2010-05-18" version="1">MLQYSSRPHTPGTRRRRTRSSCADSGLFPSPSPSPSPSPSTPPDSSYRPDSFPMAVQNCEALLGIAIHNLSSTPDFLQDSTGAMQMQASSPCPSSQPFEIGLSLRGVTTPSSPNSSTSSTSLGHHSDAAEAYKPFVCQVSPPTPLSDFMHESQPISVLDYPNMFVPDYNVDGASAFDSLQFSNVDTPVTVSTASLSMSPPLGNIPSRPSSVSDSFGIYDQPQHHHQQHPSSTMQFSRDQWNMALPIPRSTVYPDQQKLNRAMPDHCPGSNRQSMSSAHGYSDLSKPLDMHLQNLDGSIPTSQAQYGLSATSYPQAPYYTPVPSLPTTPPSTSSPTFSCPHAQAPSHSHHRTPSSSSPSPTALSEADLRSKPQCWDHGCNGRSFSTFSNLLRHQREKAGLSVKAECPYCGAAFTRSTARNGHLERGRCKAMREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6D3</accession>
    <name>D4D6D3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02658</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023195.1">
        <property type="nucleotide sequence ID" value="XM_003023149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6D3"/>
    <dbReference type="GeneID" id="9583215"/>
    <dbReference type="KEGG" id="tve:TRV_02658"/>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="40776" checksum="231482987BADE02A" modified="2010-05-18" version="1">MPQDDNEGTRERDERIERLWSSLDTRGEGQVDFKGFKKGLKKIDHPLKNADDLLYDILKAIDTSQDGRIQYSEFYSFVKQAENQLWRLFQAIDHDKNGHLDKQELKDAFVNAGLTVPSSKLDQFFADVDTNRDGVISFDEWRLCKDQVVIAPQPPSFPSIHSTASSASITPILSKTYSLHLHHNSRLIQPNTHTHTHTEIFCFAPPYNDHHKIDQGLEVELEFITVPSLVRLWLSYRYLEEVLTETTPHVGYFLAGGMAGVVSRTATAPFDRLKVYLIAQTSTNSAKSAAINAVKAGAPVKAVGWLSWPIVEATKELWRAGGIRSLFAGNGLNVVKVMPESAIKFGAYEVSFSAPPPACLHAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6T0</accession>
    <name>D4D6T0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023060.1">
        <property type="nucleotide sequence ID" value="XM_003023014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6T0"/>
    <dbReference type="GeneID" id="9583080"/>
    <dbReference type="KEGG" id="tve:TRV_02807"/>
    <dbReference type="HOGENOM" id="CLU_1712810_0_0_1"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF3">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="17396" checksum="656697EE994147B7" modified="2010-05-18" version="1">MAGEVRQPIDQASFERYIDAQVPSIKTPLTIKQVRYCSFCSACYLYNISVANGRQFGFGQSNPTYQLISADGAKYVLRKKPPGKLLSKTAHRVEREYQIIHALEKTDVPVPRTICLCEDESVIGTAFYIMEFLDGRIFVDPAMPGVTPDERREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6T6</accession>
    <name>D4D6T6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023066.1">
        <property type="nucleotide sequence ID" value="XM_003023020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6T6"/>
    <dbReference type="GeneID" id="9583086"/>
    <dbReference type="KEGG" id="tve:TRV_02813"/>
    <dbReference type="HOGENOM" id="CLU_068508_2_0_1"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="8">
        <location>
            <begin position="74"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="196" mass="20001" checksum="F25C9C6057AAC3B4" modified="2010-05-18" version="1">MTNPKEVTPPPTAAAAAPGVKALAHTAPSQPNSPLAKRPKTEAMAVPETTETAPAVPAAAPTCQLQVKKLVPEARAPTRGSAFAAGYDLYAATETVIPGRGKGLVSTGLAIAVPEGTSDLVVDGRIAPRSGLASKNFIDTGAGVIDADYRGEVKVLLFNFSGVNFTIKEGDRIAQLILERVSLLNSQSGIGSSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6W3</accession>
    <name>D4D6W3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">TRV_02840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023019.1">
        <property type="nucleotide sequence ID" value="XM_003022973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6W3"/>
    <dbReference type="GeneID" id="9583039"/>
    <dbReference type="KEGG" id="tve:TRV_02840"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000593">
        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="491" mass="53050" checksum="BB942BE84ACFA382" modified="2010-05-18" version="1">MDTLMDSTSATEGQSSQVQRQVRLRLTSRHADLALPDSTGSILVPTELRRYALSTLVNNLLELPKPVPFEFLINGRYLRTSIDEYLTANGISAETVLDVEYVRALIPPLHVASFLHDDWVSAVDILSGTSHAAQWSSKEIQSGKERILSGSYDGLLRMWNMSGETIAVSPSAGNGGHSSSIKGARMTSTNQIVSCGIDRTVRLWKYSESEDGFSASITPQVEYYGHKGSVDSIAVHGPSNRILSASADNTVGFWSTKKSESPEAPSDLLPSSASRSAKRRKVKSSVSTPQRGPLALFESHTAPVSAAIFDAKDSTVGYSTSWDHSLHTWDLVTSALVDTRTTSYSLLCVEHLPQLTLLAAGTAARHITLIDPRDSATTVSAMTLRGHTNVVVSLARDPNSQYGLISGSHDGTCRIWDIRSTKTEKDGVVGESIYSISRKSVEDEGKRVGGDGVKVFDVCWDKTVGIASVGEDKAIQINRGEGILQKDAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Y8</accession>
    <name>D4D6Y8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023044.1">
        <property type="nucleotide sequence ID" value="XM_003022998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Y8"/>
    <dbReference type="GeneID" id="9583064"/>
    <dbReference type="KEGG" id="tve:TRV_02866"/>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="349" mass="36828" checksum="DEBC076D31D046B1" modified="2010-05-18" version="1">MASPIKTPLCELLGIQHPILLAGMARTSGGPLAAAVSNAGGLGTIGGLGYSPAQLEEMLVELKSHLKDPGLPFGVDLALPKVGDGARATNHDYTHGQLDELIEVTIKHGAKLFVSAVGIPPAHTIKRLHEAGILIMNMVGAPRHAEKALQAGVDIICAQGGEGGGHTGDIPFSILIPAVVDVCRKYRSPLTGKTPLVIAAGGVNDGRSLAASLMLGAAGVWVGTRFVAAEESGASQLHKEAVVSAGFGDTVRTLVISGRPLRCRENDYIREWESRPEEILRLTKNGIVPLMKDMEEDKEIDFPFLMGQVAAVVKDIKPAKDIVDSMVAEARQMLELGCSYMGDRQGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D763</accession>
    <name>D4D763_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022955.1">
        <property type="nucleotide sequence ID" value="XM_003022909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D763"/>
    <dbReference type="GeneID" id="9582974"/>
    <dbReference type="KEGG" id="tve:TRV_02943"/>
    <dbReference type="HOGENOM" id="CLU_067876_1_0_1"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="170" mass="19474" checksum="F9B6D0679F5E0EFA" modified="2010-05-18" version="1">MFLVGNDLAGNTYWEFKDSLKPGRLRRIVKASPKIHYADVKVPLVDGWTAQWHQWLRYVRPEPPSIEEQQNELLRQQRIKYLAQQADERWASKPSFLDKPAQQDAPALQSQQPSYHTTRQGTGAGTAEVLQEQQPDAKGGKKMKNPWDRAAGGPSENWQPESWTPNVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7V6</accession>
    <name>D4D7V6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022669.1">
        <property type="nucleotide sequence ID" value="XM_003022623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7V6"/>
    <dbReference type="GeneID" id="9581328"/>
    <dbReference type="KEGG" id="tve:TRV_03190"/>
    <dbReference type="HOGENOM" id="CLU_1796068_0_0_1"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="144" mass="17160" checksum="9A7CAF2AE0D76097" modified="2010-05-18" version="1">MKDYMKRVYNVDVIKVRSYVEQQKVTRELPRGRQGVGPMRRPMPKKKMTIEMTEPFVWPEEPKDFEPWERDTFFEAKKMQEDFQAAHAHDAPMKAPTRKRQLLAEQAKQVLKGEEQWQPTWQALGLSSQRPLFNKEEREPKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7X5</accession>
    <name>D4D7X5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022688.1">
        <property type="nucleotide sequence ID" value="XM_003022642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7X5"/>
    <dbReference type="GeneID" id="9581347"/>
    <dbReference type="KEGG" id="tve:TRV_03209"/>
    <dbReference type="HOGENOM" id="CLU_095070_1_0_1"/>
    <dbReference type="OrthoDB" id="4171899at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="253" mass="28080" checksum="FDEBF7A057AAE91F" modified="2010-05-18" version="1">MPTVGNLVHRASIFGIFAFALIVYLTTRSPWTPFTENCSDCSSPAMDDQLSFIQISICPGRETVAKDEELKLKVTVTNTADSQATLLTWNTVFDTLAPSLGVFTIRDLTDDTDVEQNIMMVRRQMPARERDLVELGPKQSTETSVVFSNLELTSGHKYSVQASGFWQTVWTKPKSEVVSHHLDLSGGMNGDFSSNVVEFSKPVLQSAYTGLMRFLHIFLSIYLKQLAAKEDEAAHADKDRAESRVAEACSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D805</accession>
    <name>D4D805_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022583.1">
        <property type="nucleotide sequence ID" value="XM_003022537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D805"/>
    <dbReference type="GeneID" id="9581295"/>
    <dbReference type="KEGG" id="tve:TRV_03240"/>
    <dbReference type="HOGENOM" id="CLU_021380_0_1_1"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="695" mass="77917" checksum="721A069231F16E16" modified="2010-05-18" version="1">MLFTQRAPAFDVCRQPLNINLGRRVSNVRSEPSKDSNNHNHTSETGSGFGGGRNRRSCCEVADADSNGSSSRATSDSTTPSPTNSTANESFSRLSLEAPDDIPRGSPCPWTYTSTAEQIFSTRVFSTDRNTSDTDSPMQVSQSLSFTVISSPASAMHEEDVVPKIEEIEDEEDGTVPLSLHHGEPQDGKSDVPPSPTACVPRKRGRPRKHPPPVPGQAKVTKGRSKTGCITCRRRKKKCDETKPACLNCQKNAVVCEGYPVKEVWKSGKQKIEEAARRHSFAIFARGLPVLIDGIETDIDRRFLDHFVNDFSRVLTLINDDSNPFKEILLPMATQHKGLMHSLMCLAGSHLSARDPEPMLKERKHYHFHRAITNLRNTIAAQSSACSPSPSSTTTSTTTAETSPETRPKESRESLPVEDPMIASTIALCLHTICEGETKGEYRSHMDAARYLLITQRPRNEKFRQFIVEFFQYHDVSNSVTTLDRRPICFAGDLRLPDFVPHAQAGALLGIFDGLFHYISEITVLRDRIRQRINQGIEPAIDYQTLSEAVGIDSQIRAWEPSYPADNPNWLASQLYRQSTWVYLYRTIRPSRPDEKISQVVDDGLLYLNQLPLDSGAYSILLMPLFLLGCSAFEPYQRERIKTGFDSVQAYSSLRNIDAALRVVEKVWDVMDTSPNLSWDWEKIIDDMNMDFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D876</accession>
    <name>D4D876_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000170">
        <property type="protein sequence ID" value="EFE41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022573.1">
        <property type="nucleotide sequence ID" value="XM_003022527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D876"/>
    <dbReference type="GeneID" id="9581231"/>
    <dbReference type="KEGG" id="tve:TRV_03312"/>
    <dbReference type="HOGENOM" id="CLU_033097_0_0_1"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="524" mass="59421" checksum="FA185432DF9C5B8B" modified="2010-05-18" version="1">MTILSMRELLQFPPGDNETDTLINGVHFNTTTLNYFNYTLYSNGTLSNGSKCWLTFDIYKPLLLSNGTFINGTSCYVPIKGLKARGSVGIAFAALFAATLFLSVINLRKHGERFLPLEKRWTVVGRRAQWYWMIFLTVCGVVSCFMSIDVDRDYLPQTAIILQSFFYYLMIPVMLAMIWEGVRHWGSWQERQVVDRDSSAFPAESTRERQELFLPLLFYLFAFLSFFLYVPRSWSAIEKQRTFEQQEAIAKQAATDSRFKGGNIIAGFCICIICYSLGHSLFRYKWQAQGQPSLISIVMSIPAKFIIVITLAGISVAFNIASSFIWQISPLKYDGNPGYLYGLGYGPPLVIVTILNIFAYLESNEDRELIRQRIQRGRANDTELGIEAGRRKPAWWRRLRPDFKGDVGNSYEARLRALTTEVGGGRPTQRNIEQRVEMGVIDTNRYRDSVDSQAQSNADPFTDDHRHPQNPQSTGSEPTEAPVEPGPRTGRLHSSTASQFSQSSGETLVSQARNQPRVRSMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8D9</accession>
    <name>D4D8D9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyubiquitin UbiD/Ubi4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000175">
        <property type="protein sequence ID" value="EFE41882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022500.1">
        <property type="nucleotide sequence ID" value="XM_003022454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8D9"/>
    <dbReference type="GeneID" id="9581081"/>
    <dbReference type="KEGG" id="tve:TRV_03375"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="17689" checksum="523D97F1C99ED56E" modified="2010-05-18" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKTYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPTPECGAGIFMAAMHNRQYCGKCHLTYVFDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I4</accession>
    <name>D4D8I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box and WD domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022470.1">
        <property type="nucleotide sequence ID" value="XM_003022424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8I4"/>
    <dbReference type="GeneID" id="9581047"/>
    <dbReference type="KEGG" id="tve:TRV_03420"/>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118836" checksum="8C617D474987CD5E" modified="2010-05-18" version="1">MQPECYRSTITASENHSRYNQPTAQHGNFSHPECSASRLSGRDDGSSGYTTSSVVLPPCTSDSRLDGDAADTGLEAQLPAKPVSSPCHSSDDGALAMHRKLSEDLSPQVISIESFPNAFSRYFPGPALTEKNEGRQRGDDWEHNLLKRRAFCRLTALSSWRNEYILRTRLLHSIARGKPTSYQITDQRKSTRAGSTPAAHAVVTYNSLLQFPISHIDGTFGSGIESKPPAFVHGASEEGIATQSDPTSKKSGAGKWGLLSESRMFNHFSDSYPGEAPWGLGAGNLVGNPNVMDVSQPHGMVYGEGCPQGRTYFLSTSEKRGRFFPRSVLDPHYELGIPSVNAAHFGICATWIAKSSETLKSTNGLCGMITGTSSGILTSYALGPHPSYDQRFERGQMTARWALCPGVPIIAIRVDDKLSAKRLSQRRIWITVLNALGELFYLTSIPRGLDTYQRLEPEALEKAAWLTGRTVSWEIVESSRRVPVPDPFNKLSTNATYSPRSSSDEMNLNRDQIVAETKDIERFLAFKPIHFRTIYEGWDMRRKLEVDFAGDDGKGAGESLMVVCCSADDDRVASVKRFTRVRTGENPSLDNIGSTSPASEPEAEAKSSLFGQGESREVLSSGNRASSPMRNGFNSLPVTVEWRVSNLTFEGPKSAEITACALDMSTFARLTKFEDPLLGMCGNSEVSSLCSTPFSVLSNPLVSSAEIPGQRGRYMAVGTSLGSVFVWDIRAAIPGNSHMVNNIMPIRIIHTDSPEISSLALTALYLVHGGNDGLVQAWDHLASSTQPIRTLNSRFSSRARRRLVQATTANQNVGHNFFAAGAICLDQDPTRLRGIVALGTQLRYWAYSSSAADQYKSNKRRVRYSHRGSNSSPETQRFSNSGRGALMDYIMNEKAELERQNIAKEKELAHLSGRFGTDLLGSDASDEDLLAYACLLSEESYTSDERNRRGSESSSSGSSSSETIASDETFSANPLTRQISTPTLDTVDEELEPGLAEAIRRSLQDTDASQSSKEGSVLTEEVIPDVCSYSFSPSLSGTSSQDNVDDLDLAIQLSLAEQEGQKAPQEEFPALGSTSNTPSKRRGRGKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8J0</accession>
    <name>D4D8J0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022476.1">
        <property type="nucleotide sequence ID" value="XM_003022430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8J0"/>
    <dbReference type="GeneID" id="9581053"/>
    <dbReference type="KEGG" id="tve:TRV_03426"/>
    <dbReference type="HOGENOM" id="CLU_623986_0_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="241"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="50542" checksum="DB16DC51E944C9AF" modified="2010-05-18" version="1">MVSNSQCQFLTWVRKASRSRKQNHLDHYQQKAFEIEKDFNYSSSSISSEGTERQSLDRNHQHISSPAKISLARLIANDAAEADRLLLACRELGGFYLDLTAADLGEDVMSDADRLFGLGRDVFNLPEDEKREYDMVKFGGYYGIANTAAYRYKGYRNRALDFKEFYTVSKDEILGIQCPTKIPQPQPQPIQSSLPLIQTYIRNSHAIISLILSRLASALDLPPESLKNIHRRDANSGDQIRWIKLQASKEARPPPENDVLLDEHSDSNSVTLIFNQSGGLQFRSPQPDSSLHNLPIPRENPIITTTTTPTSTPPTTNPTPSPEPTMDFSGGPNLPANWIPANPLPGHCIILMGEQLAKLTEGGVRANVHRVCAVPGMQTSNPRYSLVYFSRPEDDVILKQLAGIPVVPRPMTAHKSSRELPSQCKRIGKVFEGKEWMGWVRPSSPRFKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S4</accession>
    <name>D4D8S4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_03512</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022301.1">
        <property type="nucleotide sequence ID" value="XM_003022255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S4"/>
    <dbReference type="GeneID" id="9576904"/>
    <dbReference type="KEGG" id="tve:TRV_03512"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="127"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="523"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="705" mass="78906" checksum="F6C010F133B7E671" modified="2010-05-18" version="1">MDYEALKDQWNDAEERDGVRLSWNTFPSTRMEASRLVVPIGAVYTPLKQRPEGTLLQYEPVTCKMPCRAVLNPFANVDIRARIWICPFCLQRNPLPPHYKDITENAIPPELHPENSTVEYRLARPAPAPPIFLYVVDTCQEEDSLKALKDSLIMSLSLLPANALVGLITFGTMAQVHEIGYTECAKSYVFRGSKDYSAKQVQEMLGLLAPNLRVAAPQQPNRPNPANSPAARFLLPVQQADYQITNVLEQLQQDPWPVANDRRPLRCTGVALSVAIGLMETSFQGAGGRVMLFTSGPASEGPGLVVGPQLKEPIRSHHDIDRDNIKYFKKAVKFYDNLAKRAAHNSHIVDIYVGCLDQVGLLEMKGLVNSTGGHMLLTDSFTSSQFKQSFVRIFDKDESDNLTMGFNASLEVLTTKELKVTGLIGHAISLNKKSSSVGETDCGIGNTCSWKMCGIDPAASYGLFFEIANQGGPAPMQQGPHRAMMQFLTYYQHSSGQYHLRVTTIARPLSSPAGDAALAHSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCSRFADYRKDDQTSFRLEKNFSLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHESVSDSLVMIQPTLDSYSLEHEGSQPVLLDSASIHPAHILLLDTFFHILIFHGETMAEWRKAGYQDQEGYENFKAILDQPKEDARVYSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D984</accession>
    <name>D4D984_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000188">
        <property type="protein sequence ID" value="EFE41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022194.1">
        <property type="nucleotide sequence ID" value="XM_003022148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D984"/>
    <dbReference type="GeneID" id="9579079"/>
    <dbReference type="KEGG" id="tve:TRV_03675"/>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="123"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="507" mass="56577" checksum="92EE946663934AA9" modified="2010-05-18" version="1">MDLQETQRITLEYLHVLADQFQRVPGSAIVLRYIKSSYQNDPVRSAVELFLFLFAVRYLLAPKYSTKRDFVPLSEEEIDDLVDDWTPEPLVLPSTAQDEEDVEKRVVLTGPTGPKSKLVNGRTVTNLASYNFYNFVANDTLKEKAIQTVRTYGVGPCGPPGFYGTQDVHMRTEADVATFLGTPACIIYSQAFSTISSVIPAFSKRGDIIVVDKGVNHAIRKGIQISRSTVRWYEHNDMDDLERVLSKITKEQAKKPLTRRFIITEGLFQDRGDMCDLPKIVELKLRYKFRLILDESVSFGVLGRTGRGITEHQNVDPAEADMIIGSLSGVFIGGGGFCAGSKEIVNHQRISASAYCYSAALTALLATTASETIALLHNSPELIVQLRENIKAMWTQLDPRSDWVYCTSAPENPVMILVLKPEVVSSKRLTIEDQHHILQEIVDETLANGVLITRLKPVPDETISKQNHIPPAPALKVCITTGLSKKEIEKAGIVIRHAITKILRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9J4</accession>
    <name>D4D9J4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022100.1">
        <property type="nucleotide sequence ID" value="XM_003022054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9J4"/>
    <dbReference type="GeneID" id="9578984"/>
    <dbReference type="KEGG" id="tve:TRV_03787"/>
    <dbReference type="HOGENOM" id="CLU_055868_0_1_1"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="333" mass="37779" checksum="8D025EFB0C60BFE2" modified="2010-05-18" version="1">MSSDGVDCEEPPCINPYEVLGVAEQAGADEIRSAYRKKALRHHPDKVSDKDKDDAHRKFQEIAFAYAILSDERRRRRYDTTGNTSESLDLEDDDFSWTDFYREQFSVMIDGTLLDKFKQEYKGSDEERADLLRVYEECKGQMDGIYERVMASDVLEDDDRFRALIRDAIEAGEVADYPAFTEEPAETKRARRRAARKEAGEAIEMARELGVEEKLFGSSSSSGRGNKSSSSKKTKGGKGGGDGGEDALMALIQQRQKSRGESFLANLEAKYAPKKHKHKKRAAEDDEPPEEAFHKPRTRTLDRDRGHHDGQNQHQPRENNAKNKSNGRKRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M7</accession>
    <name>D4D9M7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022079.1">
        <property type="nucleotide sequence ID" value="XM_003022033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M7"/>
    <dbReference type="GeneID" id="9578963"/>
    <dbReference type="KEGG" id="tve:TRV_03820"/>
    <dbReference type="HOGENOM" id="CLU_154709_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="107" mass="11738" checksum="790FBE5F7B5757E5" modified="2010-05-18" version="1">MLSEELPFLFSELSSSPAGGWLAVVVVVVVVVGGGELLEVEVEEEEVEVREKKKKKAKKKRKKKKKKKKKKVRGGSKKIPRKASGALFLFGRGGVDVEVEVDDGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA13</accession>
    <name>D4DA13_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021927.1">
        <property type="nucleotide sequence ID" value="XM_003021881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA13"/>
    <dbReference type="GeneID" id="9578810"/>
    <dbReference type="KEGG" id="tve:TRV_03957"/>
    <dbReference type="HOGENOM" id="CLU_515051_0_0_1"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="529" mass="60132" checksum="D2F58010F3D6074E" modified="2010-05-18" version="1">MWHIFTSEWSQILNQFLAVIVWLQQKRDSYERRLVELEEHFCITEERVRILKSEEGDAKSEPLANIRDLEVLPSHFGDASNTVFIEWVYLIDLDEQVFSVNNRVFFRLWNIPRDTWITPFESWDLSTEKCPEASLEPLIPDYFADDAERDRYNEMYKRYQHSDLYEFSAGVNYNPRNVMALMLYEYLLHPSHSAMWDYVPQWGYTDFAFRELAFAILSLAASEFHLTDVQKLHGHYRHQSSSRGFLVQDDAHDGTEVLPILGAGCHTSVTKPGCAPLETMYYFQGILISLVTAEALFHERNAAIAKAVEVGLQSGNKEFEIILFSIKCMIVVKVSVEDDVTSVAHSGVLPITNGGAAPFPPVAGTESALQAHPGFAILQIMFEQQAQKDLQQFSRGVFPPEIYAEILSYVDPCTELACSKVSPVFRSICQAQVTTPDGLVTKFETIDGEEDKPRSYHQLVPFGTFTFKDMKVATVAQPCRHFDDFPTAFNGPQWCAIIGTGERKCVIAQARIPIITTDLDEEQDEDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAA9</accession>
    <name>D4DAA9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021878.1">
        <property type="nucleotide sequence ID" value="XM_003021832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAA9"/>
    <dbReference type="GeneID" id="9578761"/>
    <dbReference type="KEGG" id="tve:TRV_04056"/>
    <dbReference type="HOGENOM" id="CLU_2147694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="13169" checksum="07D73E5E4E5D99BA" modified="2010-05-18" version="1">MHPFLRPIHTYTPLPPNSHFIVKKHLHDKKKTHIGKKPLRHIQHRKGEANEKPKWKKEGRKVKSTNGQNIILPFPRFIIPSFPPSLFFIPDPILFPRPLLSTPYLLLLLTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAC8</accession>
    <name>D4DAC8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000207">
        <property type="protein sequence ID" value="EFE41189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021807.1">
        <property type="nucleotide sequence ID" value="XM_003021761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAC8"/>
    <dbReference type="GeneID" id="9578694"/>
    <dbReference type="KEGG" id="tve:TRV_04075"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47988" checksum="7BB16F2A92C4FA7C" modified="2010-05-18" version="1">MSIPNCSYLPSNLSDDETLKMMDSRYPELVHMTTLNYSLVLLIFSAIYGICLVTYRLYFSPLSQFPGPKLAAMTRWYEMYFDVIRGGQFMWEIDRMHEKYGPIVRINPYELHVKDPIYYNTIYTGPTMKRDKYIWFLSAGAPNSLFSTAGYNHHRLRRGMLSPYLSKPAIRTLEPVIQEKVNLLCRHMREALMNDEPLELHRCFISLAVDIVSQYAFGKSKCFNVLQEKVLDDKWKDGVTGAFGKLLLTRHFPILIRVFRTLPVRITSLVVPTTRHIDFMESHVYETNRHGITEPCIFSELMHNEKHPVAERTLKRLTDDALFLMVAGTDAPSQALAIILYHILNNRKVHEKLREELVYALPDARSDPSLAMLENIPYLTAVIKGLRITALVTSRLPRISPDKILEYGNWKIPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAJ9</accession>
    <name>D4DAJ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000209">
        <property type="protein sequence ID" value="EFE41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021748.1">
        <property type="nucleotide sequence ID" value="XM_003021702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAJ9"/>
    <dbReference type="GeneID" id="9578628"/>
    <dbReference type="KEGG" id="tve:TRV_04146"/>
    <dbReference type="HOGENOM" id="CLU_2470695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="88" mass="10057" checksum="5F249989C2105119" modified="2010-05-18" version="1">MEMKSKSKRMNEARRGEQRDYWRDGGWRLIDANGDGNGDGDGDGEMEGWRDGEKEVWRRQRRLAVEVASLFLLSILSILSIVLSCPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAX7</accession>
    <name>D4DAX7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021602.1">
        <property type="nucleotide sequence ID" value="XM_003021556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAX7"/>
    <dbReference type="GeneID" id="9578563"/>
    <dbReference type="KEGG" id="tve:TRV_04275"/>
    <dbReference type="HOGENOM" id="CLU_018787_1_2_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="503" mass="56986" checksum="54C1AAE9845E9175" modified="2010-05-18" version="1">METHPYTCNTCQVAFRSSEAQRGHMRSDWHRYNLKRRVATLPPISSEVFTDKVLNAQASNSAAAAKATYEKSCATCQKTYYSENAFQNHIGSQKHRQREAMLRREGGKDETASVMSGTFSMGDPINERTETGEDDVEPGEQEFSEIISGIKGTKIDAHDPLPVRPRRPSHTTETEPVSAERIEKDGEKTEISLAQCFFCNYKSPNVKLNVLHMGKFHGMFIPEQEYLTDGEGLLEYLQAKIYKNSECIYCHKLKATPEAVQTHMRDKGHCMIAFETEDEQIEIGQFYDFTSTYSDDEEMEGEEGGEEGNEAQDDGWETDTSVSSLDSAEIGAEPIDDRSHQYSKLSRHSHHSNTDPRKHRNIDGFHSHAHSHGHAAFVHDGELHLPTGRTAGHRSNAKYFRQNLHNYPTPEERLTRQRMIEEAGPGADEEDAEQANNANKSRALISRANGGLGMIGASESQKKEVRGAEVRERRRADRSRRQYEWKINKGANSQKHFRDHLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBD6</accession>
    <name>D4DBD6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021462.1">
        <property type="nucleotide sequence ID" value="XM_003021416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBD6"/>
    <dbReference type="GeneID" id="9578423"/>
    <dbReference type="KEGG" id="tve:TRV_04435"/>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="259" mass="28451" checksum="880185DF56E44FCB" modified="2010-05-18" version="1">MAAQGLDQTILRDPALLALADAHNQQILTGILRHYATILMTSSPKPAASLAEFRERLALFRGVNLRTNASAVLTPSSLASRKAYLINAYKTGAFLKDPENRGAGAPNPMTDPAGMDAMMGMMKGNMAMMIPQTLIMSWINAFFSGFVILKLPFPLTIRFKSMLQSGVMTRDLDVRWVSSLSWYFLNLFGLQSVFGFILGSDNSAGQVMQQVGVTNPAVNPFQPGQDPEKIFQGEAENIEVMEHYCILDGIEERILQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG6</accession>
    <name>D4DBG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021392.1">
        <property type="nucleotide sequence ID" value="XM_003021346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578271"/>
    <dbReference type="KEGG" id="tve:TRV_04466"/>
    <dbReference type="HOGENOM" id="CLU_001013_1_1_1"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="5">
        <location>
            <begin position="253"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="4">
        <location>
            <begin position="698"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1324" mass="148287" checksum="EDED1736FEA00C62" modified="2010-05-18" version="1">MATFHDRATSATPTQYRVFGDNKRSSSSADDESADGSWHDAVSATTSRHPGGLSSSGTQASLSAKSASLAPSNVTQGSFSSDLRHSGISRNATPRPPESISHVRGNGAGDIEAATTEQRQAIIREQIEKEIKIKTGTENMLEALLAKNMKQTKEQRLRVESELSSSHRKIAQLQNELEEELMRAHMTPIEATEARRLSTFFNTGPGRSPSRATTHATGESFEAEDSESESPTVVLSETLQELEAEGMSPDYYVDRANNLVDLFKRYPTLKYDLEWSVFGLRVQVMLLSESRDVVAAGYRLTRHAIADRKSIQVIRALHTDELVMLSLVKESKASMEREQALKFVRAFLDVKDGVQELSRSVVRTLVSIAEHRDDRLRNICIMTIAELLVKDPALLFSAGGIGTLNDVLGEGTFGASESLAAGFVHVLDAPKSRKYLRAGCELNSVFANFTETVPDSDRHLKLKFSAKAISAMLKTWPGILTLAQNPERPLQSLLLSLQFPDPQSRDLILELIFDALRIKPPSWSSSFLAGRRLTTYGRVANMKSEQEKKQSRTVYEDEDNPFDLTAHFSGLILALLVEAGLINVLSDLIEDESDLSLKRKTTLLLVEVLRRAQRSLPSSMCSNLHLLPSLLPSSSPIKAKSDNQHLSTSTIYQMESISRTMTRSDDISDVSGRYSVSTEIPNSLVPGEQSKSKLSSTMDEAQFRTAILDTNVLSSVNFMKWKWDLILNIIEGPLTNPKRLDEAIKGSKFIKRLVGFYRPFKYRFSMVRNTKPNRRYIRTGCALMRCLVQSPEGSKYLAQNKLLRQIAECLAQVDRMSGLTSLSPLFSREQMADTLSGGYFALLGTLSSEPNGIQMMERWHMLNMFYHIVELADRNDLIQTLLGNMDFTHESHLRVILSKALTTGSKDIRIFSTKLLRKYVIGKVLQGSPVEWVIELLVTQLYDPDVTVCQVAVKILEEACNQRDYLEYVVKCRPSLDHLGEIGAPLLLRFLSTSVGYHYLDGLDYITQEMDDWFLGRNDAYVGLVEASLSRAYIDQPRRNSLALNDIVEMQDIGLVPPHFYRELARTTEGCKLLEQSGHFYEFASTLRDFQLDEEDAEVLLKVKGALWAIGNVGSMELSAPFLEETDIVERIVEIAENAAVMTMRGTAFFVLGLVSRSQHGLEMLIEAGWDAAVDQRGRSLGSCMPLNLSKLYSVKFEPYQARTEQDKAARNRYKVASKDSDPLKQKILGLIIDMGNTVLAKKAAADLQVKFWQGSNMFHYGSLKTNRPDCFRRIDLFEKTLVILESHHFRLSARRFALELFDKSVVRRIIVGDESVSDSEMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBR3</accession>
    <name>D4DBR3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021329.1">
        <property type="nucleotide sequence ID" value="XM_003021283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBR3"/>
    <dbReference type="GeneID" id="9578174"/>
    <dbReference type="KEGG" id="tve:TRV_04573"/>
    <dbReference type="HOGENOM" id="CLU_3108134_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="51" mass="5724" checksum="BD31A748442ECD4C" modified="2010-05-18" version="1">MFVGGYELSGKKKKKKKKQKAVDKQTLPRRGLPLRWPLTSVLSFHPDTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBR8</accession>
    <name>D4DBR8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021322.1">
        <property type="nucleotide sequence ID" value="XM_003021276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBR8"/>
    <dbReference type="GeneID" id="9578166"/>
    <dbReference type="KEGG" id="tve:TRV_04566"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="244" mass="27498" checksum="89BDB0E82921D537" modified="2010-05-18" version="1">MSPANKYSVILPTYNERRNLPIICWLIEKTFRENKLNWEVIIVDDGSPDGTLEIAKQLQAAYGEQHIVLKPREGKLGLGTAYVHGLKFATGNFIIIMDADFSHHPKFIPEMIKIQESTKADIVTGTRYASRGNLRGGVYGWDLVRKLTSRGANLIADVALMPGVSDLTGSFRLYKKPVLEKVIKVTESKGYTFQMEMMVRAKAMGYKVEECPITFVDRVYGESKLGGEEIVEYLKGVFTLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCF7</accession>
    <name>D4DCF7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021097.1">
        <property type="nucleotide sequence ID" value="XM_003021051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCF7"/>
    <dbReference type="GeneID" id="9576744"/>
    <dbReference type="KEGG" id="tve:TRV_04810"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="467" mass="50280" checksum="59312EFE5A9EE5EC" modified="2010-05-18" version="1">MLKDMAVMHPAAKMLVDLSAAQDVEAGDGTTSVVVIAGSLLGAAERLLAKGLHPTVISESFQRAAAAAVKILEDMSQPISLSDRAILLQAASTSLSSKIVSQYSSLLSPMAVDSVLRVIDPKTAENVDLRNIRIVKKVGGTIEDSEMVDGLILNQPVMKSAGGPTRVEKAKIALIQFQLSPPKPDMENQIVVNDYRQMDKILKEERTYLLNMIRKIAKTKCNVILIQKSILRDAVNDLSLNFLSRVKILAVKDIERDEVEFVCKSLGCKPIANIDSFTEDKLGTADLVEEISSSGSRYLKITGVRSPSAAQTVSIVARGANNLILDEVERSLHDALCVVRCLVKKRALIAGGGAPEIEIAQALAKQARLLAGTEAICWKAFASAMEVIPVTLAENAGLNSIKVVTDLRHRHEMGEKNAGVSIRSGGVKVNIADERVLQPLLVSTSAVELAAETVKLILRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL1</accession>
    <name>D4DCL1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021001.1">
        <property type="nucleotide sequence ID" value="XM_003020955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL1"/>
    <dbReference type="GeneID" id="9577853"/>
    <dbReference type="KEGG" id="tve:TRV_04866"/>
    <dbReference type="HOGENOM" id="CLU_2005564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="124" mass="12303" checksum="CAE43D6CB266B85D" modified="2010-05-18" version="1">MAGVAAYEADAAAAAAAAVVAAVVVVAAAAAAAAGRKKRRQSQRRGDPATASRRDSEPAGTASARSTAELPSWLLELLEGQFSPSGGGSGAGNEGAGSLCFRGHAPWACWLAGWLAGWLLGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD60</accession>
    <name>D4DD60_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020841.1">
        <property type="nucleotide sequence ID" value="XM_003020795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD60"/>
    <dbReference type="GeneID" id="9577580"/>
    <dbReference type="KEGG" id="tve:TRV_05067"/>
    <dbReference type="HOGENOM" id="CLU_008022_0_0_1"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="335"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="851" mass="94749" checksum="2C64EAE00B7B9FAC" modified="2010-05-18" version="1">MTPSIFSDSRPQSSKVSALRSILPSGGHKRSKSAFEAAVRGGPVHHNNPLAASCLLPADHPHYRPQQHHQQPYPDREANRNASNSRAPLQDNSNPPGKALHKRSKSTLSLKSLLKDKNSKDKDQAQKEPVKHEPAPRRNKPKRTKSSTSLSSLFRKHQPRQKDNDSGSRDKENFSPTDIFDDSASTAPSVYTAHLPPDNGSGSRYVPENRRTVAEEMSLYTPQGYSPSKQRNFHDHHKPSLTRADKARRKSDSIPSTSAGVREMLATGRKPSPLGPHNSNLPERKTSSSSNSQASTKSNEAPAKRRVSNGRRSSRVMAAIAAFNAKDQQAASSKQNDPKDTAIENAFEQLLESRNIPLNMRDKMRALDTNIKADFVNKHEMTPTTPSGTSQKKFGFFSSDKEADKGSENGSRKSATKTRARSRTFTKNDSSNSKKGKGETTPSKRPKSVDFSRPSSSSSRGISASVLSSLQYIRTPKDADEPSDFVHYLKEVQKPEIVEISKLHKLRILLRNETVAWVTEFMSCGGMDELIQLLYRIIKVEWREEHEDTLMHEVLLCLKALCTTTTALNHIRSIESHLFPTLLNMLFDDEKKGPSEFSTRAIIISLLFTLLSNASPGERMSRAHTILSYMRDPAPPETAQPLSFIADIYQPRPYRVWCKEVTNVTKEVFWMFLHHYNVVPVTTSEDGSVDPSQPYSERHFPPPHPPVPAAPYIGGVEWEATSYLAIHLDLMNGIIASMPTTEERNKLRTDLKASGFEKVMGRSLRTCKEQFYPALHAGLKVWVAAAAEDGWDYQFVREGPPRDAPPSSPIKTAGNQSPKKRPGIVSEAPPRLDLNVGVASSDQRKSSGDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ6</accession>
    <name>D4DDZ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020531.1">
        <property type="nucleotide sequence ID" value="XM_003020485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ6"/>
    <dbReference type="GeneID" id="9577244"/>
    <dbReference type="KEGG" id="tve:TRV_05360"/>
    <dbReference type="HOGENOM" id="CLU_013572_2_1_1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="223"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="419"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="577" mass="63602" checksum="5211C2BDFC13EDF4" modified="2010-05-18" version="1">MAKRETTPDFMGGPDSDAPAKKFMAPEDLTDSDEAEMDVSTPTTADEQDNDDGTAQPPRKKRAIERDSEAAAPPAPKWSNPDPYTVLPPEEERQGKRRDFVKLIRKARITPAVTSTPEVSSNPAVTNDDFISLGVDEPDNRPPEGAPSGPRAAELERSDSALGNRKRNRDDEITGPAVRRGKKGSRFFNLDGSPLDIWKPLDGQDPTPWFDRSSAAFHIGTMLHKEILDFYHWVKPTEYEDIVRRDLISRLQACFGQRFYGAKLYAFGSFASGLYLPTADMDLVLLSRQFMSSNRKYICQKVREIYSFAEYIRGQGLAVPGSIETIAHARVPIIKFVDALTGLKVDLSFDNSSGLAAIDTFKAWKQEYPAMPVIASIIKHFLLIRGLNDVATGGLGGFSIICLVTSILQHSPRGVGEPNLGSVLIDFFEMYGSRFDAGAVGIQFDPPGYFNKAARGIYNANKGTRLSIIDPNNPDNDISGGTKEIPLIFLTFYDAYRSLKESVYAASCRPRHSPSSLLGTIIGGNYDAYEEQRKHLRDFFLSERRFAGYHATVGLGSPPPPPPLSSPSPPPPPPHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEA9</accession>
    <name>D4DEA9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LEM3/CDC50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020417.1">
        <property type="nucleotide sequence ID" value="XM_003020371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEA9"/>
    <dbReference type="GeneID" id="9584156"/>
    <dbReference type="KEGG" id="tve:TRV_05476"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47387" checksum="CA54229D8954DE7F" modified="2010-05-18" version="1">MAPTLAHTDSLEAQDPNIHKNEKKQKSRRPANTAFRQQRLKAWQPILTPKTVLPLFFIMGIIFAPIGGLLIYASSQVEELIFDYSNCKDAPVGKDNAKDARANVRASFKTQSKGDTPYQWYKNDDVDVTLDNGVHINTTVCSLIFDIPNDIGAPVYLYYRLTNFYQNHRRYVKSLDLDQLKGVAVPNATIGTSTCDPLRLDPKGKAYYPCGLIANSVFNDTILEPRRIGGGNDGNQTYPMTNKGISWSSDKDLYKPTKYSYDQVSPPPNWIKRYPDGYTEKNPPPNVQEWEELQVWMRTAGLPTFSKLARRNDGDRMLAGSYQIDIQDNFKVDIFGGTKSIVLTTRSVMGGKNPFLGIAYVVVGGICIVLGTIFTFVHLVKPRYVNTPSFLSPIYSSLWLTSFKENLVIIAISLGTANMTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH5</accession>
    <name>D4DEH5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020371.1">
        <property type="nucleotide sequence ID" value="XM_003020325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH5"/>
    <dbReference type="GeneID" id="9584110"/>
    <dbReference type="KEGG" id="tve:TRV_05542"/>
    <dbReference type="HOGENOM" id="CLU_022195_8_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53065" checksum="576D59077A157410" modified="2010-05-18" version="1">MPPIMIFYEGQSDEGGCKGLSSANLACQKPPSCNKPKPPVGKVPPPTKRARARGCHSTCVFQDKLAYRYTKQGKPFAIKADLDNWMLMLPLESMKEWCNLPADHLSFMNYVENASAIGYHTNADCQTHINAILAYNQKKHTEWSKFNPIEVVSNVLMHYATSLVLGPKFSRDPILMQHITTHVLGIEEVINEFARWPRFLFPLLWRLSPVHRKFRSNISVVRKNVVPEIKRRVQLLRLGESTGEDMSMPTIFLKQALKEGLLSMSGNTKTEENDIESLFMKTLFHIYEVWGPITPLLSAMFVRCMANPEYVDALREEVSGSLESHGGWNSNFLAHTPKLESFMRESLHMNLPKGTCIGIPTKCVHGDPRNYPDPTTFDGYRFYDADSNTCTARASTASEKFLAFSYGTGLCPGRFIGVKVSEILLAKVLLDFDMQFISKGQEFPSYVLMENTWSWLDTNLTAYVRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEK9</accession>
    <name>D4DEK9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000299">
        <property type="protein sequence ID" value="EFE39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020332.1">
        <property type="nucleotide sequence ID" value="XM_003020286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEK9"/>
    <dbReference type="GeneID" id="9584069"/>
    <dbReference type="KEGG" id="tve:TRV_05576"/>
    <dbReference type="HOGENOM" id="CLU_033916_1_1_1"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="414" mass="43925" checksum="36EEF87D4DB0AB05" modified="2010-05-18" version="1">MATEDDNFDIDIYGDGSGLIDEGQDTTFKTEEPDLVLDGPDTQQGGGNADGSDEKYGNSNNNVDNDSHKIFKTEKSQSEAPHSGHNLPQQPPAQQQQQQQLPQQGVKRKEADPDATSALYVSDLHWWTTDDEVRGWVNKAGVEADLKDVTFSEHKVNGKSKGQAFVEFTSAQAATIAKHKIEEMNNSQQGGRKYSVTYTQPNINPFKTLPKENPMRGGKDDRTPRATPPGFNAGQGNFGMNSAVGFRGGRGGFNNRGGMNQNMGYNNRNFTPMGGGFQGGAVGGFQGNPMGGMQNYGGFNNRGGMMNNMRGNPNMRGRGGMGGMASPMMPVGGPVGNMGGVGGMGGMGGMGGMPMGGMPNQMGNMMGGMQGGNMGMQGQGFQNQNPHFNPAFFGGGGNDSGAWNPHGVKRTRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DES2</accession>
    <name>D4DES2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000309">
        <property type="protein sequence ID" value="EFE39647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020265.1">
        <property type="nucleotide sequence ID" value="XM_003020219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DES2"/>
    <dbReference type="GeneID" id="9584007"/>
    <dbReference type="KEGG" id="tve:TRV_05662"/>
    <dbReference type="HOGENOM" id="CLU_1732820_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="151" mass="16456" checksum="335C18CB453F2D48" modified="2010-05-18" version="1">MSCSPIYLATPDQCPSCGISGPRGRVLGVILGLQCYSIRKVCCSRHTYKKAFFFPHLLDFVLFLLLFFSSAAQTLPPRHRERRQASKKRQEDILYGGRKASLPPPDTTTNPCCNSSTSTTAKQQASPPPPSVAAAPFEGMFVHLPASSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF04</accession>
    <name>D4DF04_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000319">
        <property type="protein sequence ID" value="EFE39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020187.1">
        <property type="nucleotide sequence ID" value="XM_003020141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF04"/>
    <dbReference type="GeneID" id="9583958"/>
    <dbReference type="KEGG" id="tve:TRV_05745"/>
    <dbReference type="HOGENOM" id="CLU_1318219_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="209" mass="23525" checksum="6F867AF4A6F14B35" modified="2010-05-18" version="1" fragment="single">LYSSSILSILCRGGERERASVHPNLAHVVQGVAGVTTFMRMQAREGRKELDFPHAPTRCHERMDSSAQHSVLSGQAPGENIQPTAGRGGHPFRCRGHNHTQHSDWTSLLHWDRSGTKQRIGRKTMMEIKQIEIELLKLRLGSLGRGLLWLAGWLAGPGGGRVEQAALPCHHRHSEGQRDDDNSDGFFRIMFVKRSTTYHIRSRLLLHCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFU0</accession>
    <name>D4DFU0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019940.1">
        <property type="nucleotide sequence ID" value="XM_003019894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFU0"/>
    <dbReference type="GeneID" id="9584691"/>
    <dbReference type="KEGG" id="tve:TRV_06042"/>
    <dbReference type="HOGENOM" id="CLU_797377_0_0_1"/>
    <dbReference type="OrthoDB" id="4498420at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="348" mass="37833" checksum="41A4EA46F67C95AB" modified="2010-05-18" version="1">MAITLEFNRIEGHPYSWHSVRRKVEFVTQQRIKFLNGMGGKRGDDQADAAWSAAVDAWVPVWRRFQQQETERISAKQGKRGRKRKSMAVDPANLDTQNHQPPTPQPPPATQQQSQQHTPQQQQAEIQLPMGFGTMFNGTPTNNGAEHPHAHPVNAGTPDLLAPTASNPSSSSPQADPNNVSAATLKAISRLNNTPKAAISRNPNLSPSTAMLMSAAENSSTRRPFNSPSVPVSVSITDTHQQHHPHQSGPGARGSNPANPGVPVTGVSGASTANGNLTDVYMADVSAAASAVAQSISVSTIDQIRTELRAEFREQLEKERSQLEEKITSVQRTQEMILSLLNDQRFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG25</accession>
    <name>D4DG25_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein bsd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019839.1">
        <property type="nucleotide sequence ID" value="XM_003019793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG25"/>
    <dbReference type="GeneID" id="9584590"/>
    <dbReference type="KEGG" id="tve:TRV_06127"/>
    <dbReference type="HOGENOM" id="CLU_041193_0_0_1"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55611" checksum="6FFCB33F324ECF08" modified="2010-05-18" version="1">MSRWICPTVFGGSYLNLLVYWFFTHIPANWITSYLGRHVFLALSQTVPGYIQPSLPVIWRVSMLPPSSSNPITSNPSILTAWKSQNVGIKLSRDLPQAEAAEDKKTKKTKKRRTKGAGFAHLLLLLRFVLLIENVSLRSWFYPERTLEYHNLRSSLLLGGGCGRRATMTSHRYEPVNTRSEDDAVSSQATQQQPIPSSPPPSFHSRTPSPASRRVLSQDPLNSDADRTLADAFGDDDGHTDDEEGADDRQRLMRGSPANTTPDIDPSEAPAGSNSAQPAGRPNASTSRVIRGANDGVFANLSAKPERGGEKLDDLPPTYEQAAADAAPPYWETTIVAPGMSSDEVYVEGLPVGSVFSFAWNGMISTSFQLVGFLLTYLLHTTHAAKNGSRAGLGLTMVQYGFYMRNTDGYSPPDSDAGDDGYVNPPDPNSHNFNPSAVDGSGGSGSSFHGLTTSDWLSYILMVVGWFILIRAISDYLRARRHEQLILQSPNRGLPVPIIAENERSETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGH6</accession>
    <name>D4DGH6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000358">
        <property type="protein sequence ID" value="EFE39045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019690.1">
        <property type="nucleotide sequence ID" value="XM_003019644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGH6"/>
    <dbReference type="GeneID" id="9583589"/>
    <dbReference type="KEGG" id="tve:TRV_06280"/>
    <dbReference type="HOGENOM" id="CLU_110315_2_0_1"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="73" mass="8195" checksum="E95AEE049265647E" modified="2010-05-18" version="1">MGLKDKIEEIMEFRRLENRYARRKNRHTLTYGAQYVDGEYIYGPGSPAVSPSPSATTVRKQSTGGKSSKWGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGN9</accession>
    <name>D4DGN9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019626.1">
        <property type="nucleotide sequence ID" value="XM_003019580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGN9"/>
    <dbReference type="GeneID" id="9580156"/>
    <dbReference type="KEGG" id="tve:TRV_06344"/>
    <dbReference type="HOGENOM" id="CLU_1143246_0_0_1"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="221" mass="24281" checksum="A3F0C99CF8541314" modified="2010-05-18" version="1">MSRPPREAPSEVLNPPGQLVPFVYEGLCGVRHPGVNGGDGLKFTFAEFAPRAICLPGFGHTPESAHLACRFVANLAARHHADLLAMRSWDCQFCGIKASTFNLVVVSFLSPEAGTVDPIRRSVWGYGVPICRTAGSCDQKAGRLTAELRDTYISGLATPPSPSCMMCGSTEDLMLCSGCKVVRVHKKDCRAAQREKLRDKIQEHLLRQRDSHFSKFKVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP5</accession>
    <name>D4DGP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">TRV_06350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019632.1">
        <property type="nucleotide sequence ID" value="XM_003019586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP5"/>
    <dbReference type="GeneID" id="9580162"/>
    <dbReference type="KEGG" id="tve:TRV_06350"/>
    <dbReference type="HOGENOM" id="CLU_015164_1_0_1"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="656" mass="73639" checksum="EBA0B5C6AB4A0F20" modified="2010-05-18" version="1">MSDSFSLPLRPVRKKIDDTDTLPIRIAQINAQRGSFKDVTEESLSEEITALRVSGKQELDIQGTEESGNNAEDREQQLFTSRSEMLEFATQAQIEACYALDFVSLALSKYTPRQVEASMTPYVKQKIPSGSLGVDRIRTPDRTEANKKDIELVSKGWKLESFSSAANNLLEAATRLQKEVAAETKYWSEVLAIKEKGWKICRLPRERQTLGVQHGFLEAAPVFRDRGLAALRRADDGSLYVDRGIHATPPKAVRIRIQDDGNIVGVSQPARIKHDDNTSIQETLIHQARDSLFEEELFYELNREARSLIRHGVETTQNQILFQLSDNRQVLVDLVPVDDAAASDQDMTHNLPANDLAHAIACSIRLLLNHAHRKNHRRRTSIPAAISIKKKPTGEYSLLQPSIAYLQHSSHLQWLTSCLHNITATLFSAGLKYRYWKTKPPSKDTQETVTSQEKSIPLVESLVDSFLGVQETRMAGGFCTQNNWYKIMVRTDLSPSALGTEFVVWTVHSALPQKHITQRFGTREDLKEFLLYLFTLDIVHNIPFRGSRKPVSSASGASHEETEATVHGADGADTKSTTWEPTFAEDGEITASMPGEKYNKKLKVTLNEESLELLCMSLSSTTGMVEESKYIWHVDETKGEPHTTLQETLRRLEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGS9</accession>
    <name>D4DGS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019588.1">
        <property type="nucleotide sequence ID" value="XM_003019542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGS9"/>
    <dbReference type="GeneID" id="9578362"/>
    <dbReference type="KEGG" id="tve:TRV_06384"/>
    <dbReference type="HOGENOM" id="CLU_092507_1_0_1"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="128" mass="14390" checksum="D95E5D2366E8A12F" modified="2010-05-18" version="1">MSSDESRSSETAEARAAFTASLKSVGANLDADLRTRAGTLHDNAAVIDKQQEDLKRTTQDVSKQSKELEKLLDQGQNGLKEVGDLQNFAEVMERDLLVLEETLRLAEEEDQRVGRVEKPAQSWLKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGU4</accession>
    <name>D4DGU4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019603.1">
        <property type="nucleotide sequence ID" value="XM_003019557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGU4"/>
    <dbReference type="GeneID" id="9578377"/>
    <dbReference type="KEGG" id="tve:TRV_06399"/>
    <dbReference type="HOGENOM" id="CLU_026242_0_0_1"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="408" mass="45353" checksum="86F43C66F4BCAE9A" modified="2010-05-18" version="1">MSGDFFIDSPVPPKLDLTGARSRFYHSPQPASATSSLSLCRTLSTPLMSSCKRARYGYGGLDDRAIWDRQSPVSRISSPVPLANTEYLLAEGGLDTGLLTTAGQPILGFSSQRDGDNEESELDYRPTRYRKTSRTMGDVPVTPSNIEGTKRKRDSPVPQGDDTGVKSSPGWGEAVLNLVGGVAGKVWNFCVSAPFRGFHAGGGIGYDMDGSTATVPPSKKRERPSLSQRRRSSRLMDDIPVPGRYPVDEHYHIDKPRREDIHNNWVLVKEDEDSREISPSCSSKKHARRNSVARHVPARRSGARVQSKRPMTPLTPTRSTNLSPHIYSPSSASSVYKTPPKHTTVSNPNETPLSRETQRHAAKLRRKEREEDASIRRLNHQLKAMIREGRQALGTRIEVDEMDIDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGW4</accession>
    <name>D4DGW4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019545.1">
        <property type="nucleotide sequence ID" value="XM_003019499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGW4"/>
    <dbReference type="GeneID" id="9578319"/>
    <dbReference type="KEGG" id="tve:TRV_06419"/>
    <dbReference type="HOGENOM" id="CLU_1778808_0_0_1"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="146" mass="15616" checksum="5B3A07EA3FEB62E3" modified="2010-05-18" version="1">MSITVGSLFGQDQSALEDLGLLPEDVDAGTQLAPVTSSRSITPAASSSRQVASAEPQVFVTRQSGTLGGIPWFEEMIEGSRLGRVGKHRRGVGGNDTMHVEWEVTEWHDTVPSISTETSETTGSPRISAKRKSPQVCLSYAIITIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB7</accession>
    <name>D4DHB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019406.1">
        <property type="nucleotide sequence ID" value="XM_003019360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB7"/>
    <dbReference type="GeneID" id="9580122"/>
    <dbReference type="KEGG" id="tve:TRV_06573"/>
    <dbReference type="HOGENOM" id="CLU_022138_3_0_1"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="351" mass="37094" checksum="B2E103A3E886C39A" modified="2010-05-18" version="1">MFGLRAASRASHLACRRGAVRSLATEAKLAPDFVRIVEVSPRDGLQNEKKSIPLETKLELISRLAGTGLQTIEAGSFVPAKWVPQMASTADILSHLTKTPPSAPHPISYNYLVPNVKGLETLVKVLEKETAALPEQARPTELPEISLFAAATEAFSKANTNCTIEESLARIGPIVSLAKEKNIRVRGYVSVALGCPYEGPDVDPHKVAEITASLLEMGADEVSVADTTGMGTAPRTQQLLRTLSAAGIATNDLALHFHDTYGQALVNTIVGLEHGIRTFDSSVGGLGGCPYSKGATGNVSTEDLIHTIHSLGMKTGVSLEAVAKIGAWISAELGRENDSRAGKATVSRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHQ1</accession>
    <name>D4DHQ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="ACYE01000383">
        <property type="protein sequence ID" value="EFE38619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019264.1">
        <property type="nucleotide sequence ID" value="XM_003019218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHQ1"/>
    <dbReference type="GeneID" id="9577503"/>
    <dbReference type="KEGG" id="tve:TRV_06708"/>
    <dbReference type="HOGENOM" id="CLU_030821_0_0_1"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="219" mass="23757" checksum="448F60B14C80435F" modified="2010-05-18" version="1">MVVLKTHIDIITDFSPQTVEGLKAAAQKHNFLIFEDRKFVDIGHTVQMQYHGGSLRISEWAHIVNCAVLAGSGIVDALAQISSSGVFPYPAGERGLLILAEMTSKGSLATGEYTKLSVEMARRHAGFVMGFVATRSLGDIETETERKADEDFVLFTTGVNLASKGDQLGQQYQTPESAVGRGADFIISGRGIYAAPDPVEAIKQYQSAGWSAYLKRISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHQ4</accession>
    <name>D4DHQ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000383">
        <property type="protein sequence ID" value="EFE38622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019267.1">
        <property type="nucleotide sequence ID" value="XM_003019221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHQ4"/>
    <dbReference type="GeneID" id="9577506"/>
    <dbReference type="KEGG" id="tve:TRV_06711"/>
    <dbReference type="HOGENOM" id="CLU_1332772_0_0_1"/>
    <dbReference type="OrthoDB" id="4173432at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="26321" checksum="B1525A8D6FFE821D" modified="2010-05-18" version="1">MSVDKQEDEDRQQASSSSSMAPPPPKNKDTSPLTKWDLQKSPTPDISSGPFFHWRLGVAGERAKEWHVSTASHLIASMCFIYLTFETQKSDMRTIRTLSHREIDYIRNMLLRLIRKLYRKEDADISVSRLIDLAETTSFDELNDYPVPVRYWQSIRGIRDYYRYDGQNLPEPSDTACHFAWHMAQENKTHLRRRWTEAFELAYGFAIDEVASQGNPSEGFPNAPGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHQ9</accession>
    <name>D4DHQ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000384">
        <property type="protein sequence ID" value="EFE38608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019253.1">
        <property type="nucleotide sequence ID" value="XM_003019207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHQ9"/>
    <dbReference type="GeneID" id="9577491"/>
    <dbReference type="KEGG" id="tve:TRV_06716"/>
    <dbReference type="HOGENOM" id="CLU_044997_2_1_1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="54"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="33053" checksum="502FCD15D116F066" modified="2010-05-18" version="1">MAKTQKNKATSFHLGQLKAKLAKLKRELLTPSGGGGGGGANVLSGFIGFPSVAAAYEFTTLTTVPGQVLYNGAKIQMLDLPGIIQGAKDGKGRGRQVIAVAKTCHLIFIVLDVNKPLTDKKIIENELEGFGIRINKEPPNIIFKKKDKGGIAITNTVPLTHIDHSEIKAVMNEYKISSADIAIRCDATIDDLIDVLEARSRSYIPVIYALNKIDAISIEELDLLYRIPNACPISSERGWNIDELLELMWEKLNLRRVYTKPKGKNPDYNEPVVLRSTACTVEDFVRPVFLLLLPGYFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DID0</accession>
    <name>D4DID0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019037.1">
        <property type="nucleotide sequence ID" value="XM_003018991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DID0"/>
    <dbReference type="GeneID" id="9582445"/>
    <dbReference type="KEGG" id="tve:TRV_06938"/>
    <dbReference type="HOGENOM" id="CLU_2470698_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="88" mass="9717" checksum="7D8070407E671301" modified="2010-05-18" version="1">MKTPTIFTGGALLAFLRLFLLGSHRIYLLSTSSSVVVDDNVDADEVVEVVEVEVEVEKDVEEKTLRISSLGQQAAEFADRIRLRPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIG5</accession>
    <name>D4DIG5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018962.1">
        <property type="nucleotide sequence ID" value="XM_003018916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIG5"/>
    <dbReference type="GeneID" id="9582122"/>
    <dbReference type="KEGG" id="tve:TRV_06973"/>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="11">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="206" mass="21981" checksum="49B2134EAD153A41" modified="2010-05-18" version="1">MANPRVEELPEEDVKATVEESSDSEAGDEGAEELNIPGGSGVTVLSRNEKKARKAIGKLGLKHVPGITRVTLRRPKNILFVINQPDVYRSPTSNTWIIFGEAKIEDLNSQAQASAAQQLAASESANAAAGEAAGQEAIDLGKGKAAETEKKEEEDEDDGEEVDDTGLEAKDIELVMAQANVSRKKAVKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH9</accession>
    <name>D4DIH9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018976.1">
        <property type="nucleotide sequence ID" value="XM_003018930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIH9"/>
    <dbReference type="GeneID" id="9582138"/>
    <dbReference type="KEGG" id="tve:TRV_06989"/>
    <dbReference type="HOGENOM" id="CLU_050888_0_0_1"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="30935" checksum="3FCDB9B342D5C624" modified="2010-05-18" version="1">MYLYMKTVERSHMPNKWWEKVRLSSNYAKALGQLDERLIYWPKFLIHKCKQRLTRLTQVNIRMRKLAKEEERLGEKLVPKLAPKIRRREETRERKAEAAAKLERAIERELIERLRSGAYGEQPLNVQENIWKKVLKGLERQGDGERDEDLDEGIEEELEEEEEGVGEVEYVSDIDEDEDMEDLEDWLGDESDETDGDGADDDDDEGESDDGEASSDETNEEEEPKKKHAAAPKRKRPAAPSRPRKKGAHVEIEYETEGPAREPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIP8</accession>
    <name>D4DIP8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_07058</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018926.1">
        <property type="nucleotide sequence ID" value="XM_003018880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIP8"/>
    <dbReference type="GeneID" id="9582086"/>
    <dbReference type="KEGG" id="tve:TRV_07058"/>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="241"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="806"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE38281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="922" mass="101381" checksum="5348A79FD3B548AB" modified="2010-05-18" version="1">MSGRLLSRSATLLSGRTVARQFQYLGVTRAGGLINPQGNAYLRVRSWPLGTNAIHNVPAVRTISFARVLPKLALKLARIPAMFGGAMIAGLAYIQYQAAQAGNYAIDVIKSAGQTAGGVALDALQGLRDIAEQTQQGIQNTKDNIQVPEWVQKILRMNEFAPSGHGGSSGGGGSGDGGGSPKKSSTGIAMAGAAAGSSLGFDSDQENRSAATLALDEQMMTLTRKMIEIRNMLQRVGQSNTLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPDSSAEYGEFPALGLGKITDFSQIQRTLTDLNLAVPEKECVIDEPIQLSIYSPHVPDLSLIDLPGYIQVAGRGQPQELKQKISDLCDKYIQAPNIILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDPERGASILSDRKYPLRLGYVGIISRIPQSAGLFSRGSGNISNAIVKNENAYFNAHPREFGPDSELFVGTSVLRKKLMQTLEQTMASNLAGTRDAVSQELEEATYEFKVQYNDRPLSAESYLAESLDSFKRSFKEFSEGFGRPQVRELLKAQLDQRVLDILAQRYWNKPIEDISLALPEVDPLSSLPTSSPDSLYWRRKLDASSSALTKLGIGRLATTIVANSLQNHIDSLVASSTFNAHPYARKIIEEASTTILNDRFFSTSDQVENCIKPYKFEIEVDDMEWSKGRENVTRSLKEELKACESALKNVENAVGKRKLRDVMSFVDKSRKGDINIEGDNTGGAGGFSASLIEQARNAAFLRDRADILKMRLLAVRSKQCSSKKNRHYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYHFPRELDLRLGRHLSEAEVERFAREDPRIRRHLDVIQKKEMLELVLEKIESLRQLEGRSKSNPNQAAATKERVKGSWRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ03</accession>
    <name>D4DJ03_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018808.1">
        <property type="nucleotide sequence ID" value="XM_003018762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ03"/>
    <dbReference type="GeneID" id="9581206"/>
    <dbReference type="KEGG" id="tve:TRV_07168"/>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="502"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="605" mass="66655" checksum="F0BE2565F453B83B" modified="2010-05-18" version="1">MIREIDALDGVAGRTVDKAGIQFRILNRSKGPAVWGPRAQIDRSLYKKYMLEELSKTPGLNIVEGKVADIVISKENMTSLNGSQGEIVGVRLESGEMIPTQKVIITTGTFLGGEIHIGLDVFPSGRMGEAATFGLSKSLREAGFQLGRLKTGTPPRLDRKTIDFSTLEVQPGDSPPSPFSYLNDSVQIGDKGQLNCWAAHTNEASHAVVRDNLNKSIHIRETVNGPRYCPSLESKIIRFKDKPRHMIWLEPEGLAPNDVIYPNGISMTIPADAQEKMLRTVRGLENVTMLQPGYGVEYDYVDPRSLRPTLETKLIGGLYLAGQINGTTGYEEAAAQGIIAGINAGLASQLKPPMTLSRADGFIGIMIDDLITKGVSEPYRMFTTRSEYRISTRSDNADLRLTAKGRAAGVVSDKRWRQFNETKEQMSYLQALLENTKYPSTVWSRKGFPVRTDSSVRSAFELLSHNGVSLDDVIPHIESAPGTIHSLSSFSPEIKSRMAIEGRYAPYTKRQEATALLFERDEGMLLPPDIDYSTMLGLSTEERQVLEKVRPVSIGMARRVEGVTPVGALKLLMHVRKLRLLELRKDESACSIADRDASTAMASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ28</accession>
    <name>D4DJ28_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018791.1">
        <property type="nucleotide sequence ID" value="XM_003018745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ28"/>
    <dbReference type="GeneID" id="9581188"/>
    <dbReference type="KEGG" id="tve:TRV_07193"/>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_1"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="312" mass="34002" checksum="BA145CD2011042BD" modified="2010-05-18" version="1">MTITSDTYKEPVHIGVIGGTGLSELPHFTKVATLNITTPWGEPSSPISILHHTCSTSGKVVPIAFISRHGLHHQLSPHEVPSRANIAALRSIGVRSVVAFSAVGSLQEEIKPRDFVVPDQVIDRTKGVRPWTFFEDGIVNHVGFADPFDEKMAKVVRACGHSLEGEGVVLHDRGTLICMEGPQFSTRAESNLYRSWGGSVINMSCLPESKLAREAEMAYQMICMSTDYDCWHCGTEDVTVEMVMGNMKANAVNAKNFISAVLDELTKDEHADLVKGKHLEGSAKFGLSTKPGNISASALSKMSWLFPGYFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ29</accession>
    <name>D4DJ29_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellular morphogenesis protein (Bud22), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018792.1">
        <property type="nucleotide sequence ID" value="XM_003018746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ29"/>
    <dbReference type="GeneID" id="9581189"/>
    <dbReference type="KEGG" id="tve:TRV_07194"/>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="430" mass="48252" checksum="CCBE30EC6ECA83BB" modified="2010-05-18" version="1">MAKRKRDVLEEDDSYNWGDKKLRIQRLRLDQAVQHGVVLLHRALKVARGFERQKLGRREKSARQESDRMLLNRRLNEVEALKALDLHKTAERYLIKQMVKTKRIAESPAFIHLKLAERISNEGKKGDAEANVSARLFNSNPVKKVFPGIMNDIRHILGLSGDTESKKFAAKGGQKQLSKSMREDRAMGDNDESTDGEPEGSHDDEEMNMSRFDGLVASGSEDGNGNDNGDNNKTKPASARYNPMDDMSLSPTSSDTSDESDVITTKSSKPKQKSTTATTFLPTLMGGYWSGSESEPEQDYTSAIPERKNRMGQQARRKLWEKKYGSNARHIQKQAKEQAQGKNRDSGWDLRRGATTEEDTRGRYGRNKIRGGQRKEATGSNTAQVQAVPPTPKTAPPNNDKPLHPSWQAAIKRKQSKAQTSFQGKKVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJD7</accession>
    <name>D4DJD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_07303</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000436">
        <property type="protein sequence ID" value="EFE38026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018671.1">
        <property type="nucleotide sequence ID" value="XM_003018625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJD7"/>
    <dbReference type="GeneID" id="9580834"/>
    <dbReference type="KEGG" id="tve:TRV_07303"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="285"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE38026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1187" mass="126059" checksum="A61CD07A082461F8" modified="2010-05-18" version="1">MAPSIPRAPGSGTPSAPAEATHMTTTTIKVDGMTCGACTSAVESAFQGVDGAGEVSVSLMMGRAVVQHDSEVLSAEKVAEIIEDRGFDAEVLSTDIPRKENGKPTKESIPSQCTTTLSVQGMTCGACTSAVEGGFTDVPGVESATVSLLSERAVVVHDPSIITAEQIAEIIEDRGFDSTVIESKTSDPDSPRVMPSVKSSAQMKSTVSIEGMTCGACTSAVENAVAGLPGLIRFNISLLAERAVIVHDPSVLPALKISEAIEDAGFDARILFSEPDTSINSTSSTPLNFNVYGLTDASSAAALEDILLKTPGILSASVRLSSSQASVSFNPSQVGIRAVAKVFEDAGYNALLTESDDNNAQLESLAKTREIHEWRKAFLLSLSFAIPVMLISMIFPMYLHFLDFGSVELIPGLFLGDVACMFLTIPVQFGIGLRFYRAAFKSLRHRSPTMDVLIMLSTSLAFSFSILAMLVSVLLSPHSKPSTVFETSTMLITFITLGRWLENRAKGHTSRALSRLMSLTPSMATIYDDPVAAEKAAESWKKSCNSMSADKPETTSTAIHSGQKIIPTELIQVGDIVCIRPGDKIAADGVVIRGEMYVDESMVTGEAIPIIKTTGHHVIAGTVNGTGWADFQVTRAGRDTQLSQIVKLVQEAQTNRAPIQRMADTVAGYFVPTIITLGFVTFIGWMILSHLLPHPPKIFLVEGSGGTLMVCLKICISVIVFACPCALGLSTPTAVMVGTGVGAEHGILVKGGAALEAATKIKHVIFDKTGTVTMGKTSVAEAKMEPTWSTNEWRRQLWWLIVGLTEMTSEHPIGKTIVSKAKSESGVPDDGPLDGAVVDFEAIVGKGVSATVEPTSGPERHQYTSHIGNAVFMRSKGIKIPDSADSDDKKQKSKSEALKTATVIHVAINGQYSGTLWIQDSIKPSAKAAIAALHRMGLTTSLVTGDTYNTALAVANEVGIPSGSIHASISPLEKQAIISKLQTPEYPIAMVGDGINDSPALATASVGIALSSGTEVAMEAADIVLMRPEDLLSVPASLCLSISIFNRIKLNLLWACVYNAIGIPFAMGLFLPFGGVTLHPMAAGAAMAASSVSVVVSSLLLKFWRRPSWLKIERLEREVDEGLIDSTGQAYGKVGKWWKKSPFTSPVSPAESNLAGAFQFISRAFGRRRTPTEEDGYVPLQTVDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJG6</accession>
    <name>D4DJG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018644.1">
        <property type="nucleotide sequence ID" value="XM_003018598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580795"/>
    <dbReference type="KEGG" id="tve:TRV_07332"/>
    <dbReference type="HOGENOM" id="CLU_002311_0_0_1"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="864"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="862"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1291" mass="141669" checksum="68266B5291F933E2" modified="2010-05-18" version="1">MATASPRSTRSGTPSNTQKSTEGSGNHHGSSPASMTPRRKIKAMLAALDSDSEPDNATSKPFARPNPDRPANEMDEDSEDDQEDQLPVAPRGRLAARMLASAYSKESTLPESKSITTSRDTSKDISSNKEMFGLDSGPESEDDDVVAFGRKGRTTQARESRSPSHLRNDAPSRSPSPLFVPMESPSPAKTTQRDAAISVASPPVSRLQSLVNEKRMKLKQLEQEKLAKEQEREQRSMELDTDGDGEDEDDEDDEAVQRLTQQPRPMRKASKKALLEMNRETQRIARNMQLAHEATTKKKITIESFLARFNKKPVSAPSNSGSCSDTPAQTSDAEALHSTPPTSPLRETLQKDQGDKPAAIDETAPNSENLLKEDMEITIDDLLTKSNESEIPQQETTERQCLKGKPVAIPNVPKVTKPGRKIQVRLSPETIAQNQRHDSDSDLEVVTSPHQARRLALFENVTTQKSHKLSNSLRTLKALAQLQSSRKPQPMTQGDLDDILLRKAREQAAQQREEKLAALRAKGVIIQTAEECVRGEEEVEDLVEKAREEADQIAKQEKAASKRAAAKSNSEGVDDIASDEEEEYVEDAEEDSESENSERSEEEQETMDSDDGCDEDEDKEQNTKFLDNQAEESADEDEEGETQDCSKLSLRQRNRAKLVVSDDEDEKPVEMQVTATPKPKIPNIGQPTTPLIGLSQAFAATLGNSQEDSQEDSLAQLRKMPGIDLPVADLFDSDSQGFAPETQGQESGTLDIFAGFPEHNTPAIDSPSTKTYTEYSQLPEPTQDDGFVMSPFDQAKRFRPTPSTLAGSVITSNQDGDHRKERKRLRRGNAHQGTVAGDDDQPHTNVDAFKLMKNKASKPFIKDKSKAKEMVEEAAEESDDEYAGLGGASDEDSGSEDEFDRQMINDNSGEVVDEKELAAMNAHHEREQDEFQVNKLMKDITTGALRRKRVGDALDLSDSDDERISRRRAAKRREFMKMRKALLADEKIGKIAEDPKKAAFMRTIEDMDFDNDSDFLEEGEDTDNYVASQGSNNNSNDSSQKDGESATRKRPFDADAADSLNRIPVKSRKLARKASMKKPLTLAEIRETVSFVLDGPNTDASSAVPLSSNVMPHDEAAQPDHSGGIEEADFIDDGGALQTGKQDRTGSVDNAAQPRRQRGNVVDRLALRRQASSNAASGSKLAFHSSMNSAGPEFKLPPFLQRRSSSGLSVATTKSSTSTSSGSSVVVTESAGVQGSRKGAVNYYAAAREKERELQLKKGLKSSSSSNLIAQRMNMGGGLSGLLGSRPSEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI5</accession>
    <name>D4DJI5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018663.1">
        <property type="nucleotide sequence ID" value="XM_003018617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI5"/>
    <dbReference type="GeneID" id="9580816"/>
    <dbReference type="KEGG" id="tve:TRV_07353"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_1_1"/>
    <dbReference type="OrthoDB" id="4183528at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="36"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="635"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="726" mass="82708" checksum="6BBD91D5C754D981" modified="2010-05-18" version="1">MEAMMATESLVGLESIEQRDLMNLVDRLRRAGLSSVLQLPQIVVCGDQSSGKSSVLEAITEIPFPRKENLCTRFATEIIMRRDVESAIHCKINPDTGRTEEEKLELRKFSKSIHDFTELPSIIDDATNAMGLGGKVAFSRDVLSVEICGPDLPQLTVVDLPGLIHSANKTQSDEDVELIKSLVESYISQKRTIILAVISAKNDYANQVILKNCRLFDPNGARTLGVVTKPDFLRPGSENEKSWLDLVRNRDIYFELGWHLLKNRSDDEHQLSFAERNSKERVFFNTGNYNELPQSVKGIDSLRQRLSELLFNHLKRELPILKEELDKMANSVHIELEHLGRSRATIADQRAYLADFFGSANDLVAMGINGNYEEKFFNAVNVTKNIDGKENSSRLRAVVQYLNSRFADLMNQKGHKYYVYGCDGQSENKSSEEGSPEDDFISPAVRSSLGAVENLTRKEAVKRIVQVIKRNRGRELPGTFNPMLTSHLFWEQSSGWKAIAQDHANNVALKCKDFLVQVLEYTATPELMSRIMTLTVVPALRAAHEAALNELERINDDRKRHPITYNHYFTDTLQKTRTQYWVDKVRNLAKQSAVHVSEKTGTGEPKFQTKEYFKPDKFLSGIDSLVEKNMDKFAAEQALDTLNAYYKTERKYFIDVIAKQVVERHLVAPLNEIFAPRVLARYSDKQIHFLAAETIDMIRRREHLESRYKILKEGQEAFYMAMGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ0</accession>
    <name>D4DJJ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018668.1">
        <property type="nucleotide sequence ID" value="XM_003018622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ0"/>
    <dbReference type="GeneID" id="9580821"/>
    <dbReference type="KEGG" id="tve:TRV_07358"/>
    <dbReference type="HOGENOM" id="CLU_1929120_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15379" checksum="30D82649955E6749" modified="2010-05-18" version="1">MDFQQNVRREDEKRWTIFFPVPVDEVEDEVEDDEVVSWIDRRRHHREIRREEEKKKKKMMIEMKRDDDITVEETAGSPLCLLSVLLLLLLLSDFALAAGFSLASSLQLDFLSSLRLLLLFSSMFTVDCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ9</accession>
    <name>D4DJJ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 299 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018607.1">
        <property type="nucleotide sequence ID" value="XM_003018561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ9"/>
    <dbReference type="GeneID" id="9584534"/>
    <dbReference type="KEGG" id="tve:TRV_07367"/>
    <dbReference type="HOGENOM" id="CLU_084284_0_0_1"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27734" checksum="E718B6DDE13A7A29" modified="2010-05-18" version="1">MRATLRLLANVKPARYLEPFTPTGLTGLSTHPSPRPTLIYLYTTTLQKLKAIPESSVYRKSTEALTKHRLDVVQSTKPPGFDAWLQRVRALVAENPDKYKAALREDGTYAAFQLEEENIAKEDELWGGDTSKVQQEGAYLSEEEMEERIKESEAEAARQTTPTIHWEAEPALEAAQSYTDANEIHIRISEIENKIGGGLIEEVIQVAEGELRLVDEMVKSKVWEELVEKPKPGQWTYFERTESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK07</accession>
    <name>D4DK07_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000448">
        <property type="protein sequence ID" value="EFE37817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018462.1">
        <property type="nucleotide sequence ID" value="XM_003018416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK07"/>
    <dbReference type="GeneID" id="9584387"/>
    <dbReference type="KEGG" id="tve:TRV_07527"/>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_1"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="20085" checksum="D071813B1D4439AA" modified="2010-05-18" version="1">MIAMSPTVSLKGSIKFSMKKMLAGGEMSSSTFTGPGELLLAPSMLGDISILRLNGQEQWSVGKDAFLACTQGVVKDYKNQGLSKAFFSGEGLFVYKISGTGILFVQSFGAIIRKDLVDGEKYIVDNGHLVSWNCKYVMERVASGGVLSNLSSGEGLVCKFTGPGTIYLQTRNPSAFASWMVANGAAGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK26</accession>
    <name>D4DK26_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018447.1">
        <property type="nucleotide sequence ID" value="XM_003018401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK26"/>
    <dbReference type="GeneID" id="9584377"/>
    <dbReference type="KEGG" id="tve:TRV_07547"/>
    <dbReference type="HOGENOM" id="CLU_2322021_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="99" mass="11378" checksum="3D96616543808B94" modified="2010-05-18" version="1">MTENYVIVVLLLMTPVMILILWKIGRRILEAIRHGILLSRMQQETREEEAARVAQEIQQAEQLAELSAMMAAHRSCRHQPVQYRAPQPIQQPQPAHVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE0</accession>
    <name>D4DKE0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018317.1">
        <property type="nucleotide sequence ID" value="XM_003018271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKE0"/>
    <dbReference type="GeneID" id="9580019"/>
    <dbReference type="KEGG" id="tve:TRV_07662"/>
    <dbReference type="HOGENOM" id="CLU_019947_0_0_1"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="646"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="809" mass="84271" checksum="EF4118BE61350CA8" modified="2010-05-18" version="1">MDPTSSPSLTSLSECESIAIPSTFQSQAGSKSKPNPEPQAPAADSGVPLASGCGTVTVTAGSSSTAMDERKPAVPEDAGRKSGKESRRNSRAPATNTDTSHMISQQETPAAATATGPKQKRVRKRKDDEEKAKPKRERNSTGDKAVAGAAGGAAAAAGKDGSEPKPRRQRNSNVKPQDGGGDAAATAASRKKAKLEHTADEVTPSVTPRQTKITDMVSMTSTATAHPPQLSQQQQQHQFSQHPPQTSSAQPSPTPAYSMQRSLSQHSPQPSPHHPASYPQRNGNYEAGGTSGSPYAYNNNSTTTTTNNTHHAPPPPPPQQAQPASLPRSSGQNYDPIRSAIESSSSVSTPAVPTAKPAPAPQGSSSFSPPPNTVTPPPRPATTPFRASASPAISSIIDFPAANSTPAISIPPPVTTTSDNKPTLSPTQNPANGATESSKPSAQPLTHSKSQDSNAMDIDSKPASSKPGPKKNTASSTGNPSSGALSPKPASSRNKEPPRPLPSTGSGLLSNALFGGDTSSSSDTKYLPNIILNIPIKGKSNLVINFARMAEEQYGFDALHPRIAAQKERRARLAAASAVLEKSERAGRGESGAEDDLSLDVDRDSDGDGDVNMSGMGAHTPNGTGTDEATAAPNPNGEVKKPRRRKIEEYDRDDPFVDDSELIWEEQAAACKDGFFVYSGLLVQEGDKVSVEKYALSLYRLLGPYITVLTNVFYRADGTTKRGRGRRGGASGTTHGNSGTSSRGRGGHAGSSSTTNHPNGDGATAGKSGTGRGGARKPRITKADRLQMEKEKIEREKMAIGLSGKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKW0</accession>
    <name>D4DKW0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018138.1">
        <property type="nucleotide sequence ID" value="XM_003018092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKW0"/>
    <dbReference type="GeneID" id="9579347"/>
    <dbReference type="KEGG" id="tve:TRV_07834"/>
    <dbReference type="HOGENOM" id="CLU_056632_0_0_1"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="16749" checksum="F7446403846A7B43" modified="2010-05-18" version="1">MVQVSSGLTIFDLTINGLSPGRYWATIRETGDVSRGPESTGGVWEAVKELKEKQQQGSSGSGSDPRGVVGSVDVDENGKGNVFLDRPIAVWEMIGRSMVVSRQREGPFSIDDEDTIVGVVARSAGVWDNEKMVCSCSGKNVWEEREEQRSRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKW3</accession>
    <name>D4DKW3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018141.1">
        <property type="nucleotide sequence ID" value="XM_003018095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579350"/>
    <dbReference type="KEGG" id="tve:TRV_07837"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_4_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="783"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2320"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3394"/>
            <end position="3470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3864" mass="428548" checksum="F5D243C4A508A99C" modified="2010-05-18" version="1">MPPYLSTQAGFPLPVDQFENHPTSKVPIVQVKEELAQFCFELPSDLEDFRAKSGITSLQILLAGWAITLRYYTASESVTVGNIVWHCDGSYCNGQYEVGLDDDTPLLRAVEQFRHQSDCDSRDSNSTSPDTLMADTFVIQNLSTSALPFNRSPVFNIRGCKIPTSHTITVDIVNNGLREQVELDIYLNESWGKHIVNMSRTFEQVVSEMLRKPTGKLGDLDLCSAWDITTLTTWNGEISIEGSDKCVHDMISLRCAQDPNYTAIQSWDGNISYGELDELSSALAVRLVASHPSIGPETFIPLLFEKSKWTVVSLLAVIKAGAGFVLLDPSLPLKRLEDICRQVKATVVITSPQHSVLASTLETPIFIASEKTIGTPTPLDYHRTSAQPTNPLYAIFTSGSTGNPKGIVIEHGSFLSSALAYIKTVDLNRTSRVLQFASYAFDVSVSDILYSLLSGATLCIPSDAERNNSLVELIDRLKPNWMDLTPSFLRSLSPADLYTVRTIVLSGEAMTQDVIAKWDSEVRLLNVYGPAECSIQSTVQTVVAADPVNIGHAITGASWVVSPSDHNRLMPIGAIGELLIEGSHVGRGYIGNPENTQKVFIKSTEWLPGFRKDHQALYKTGDLVQYQPDGSMRYIGRKDTQVKLRGQRIELAEVEHYARECFSEARDVVTEMVKPQYEGGTPMLIAFVHCPKDHIGQNASQSREEAIFAKPDDCFRDRSANAREKMANSLPNYMIPTIFIPLARVPLSATGKTDRKLLRSLATALPRVNLDSYSMNINKSRVLPSTDMEKCLHSVFAEVLNLAPEMLSIDDDFFRSGGDSITAMQVITQCRKQGVVLALSEIFRLKTIMKIAKGATFGATTTLSRQQQEDHIGVPFGLSPIQDMYFEDCPEGHNDFNQSFFLAFARPVGEVELTNALELLITRHSMLRARFHRCSEGKWTQSISRDVPGSYRLRSHQLSRREEVTAIMVKSQTRLNPQTGPLFSVDFIEIANDKTQYVFLVAHHLVIDLVSWRILLAELEEVLETGTISQDVPIPFQAWYRLQSEYAQKYLPPQKALHFRPIPIETDYWGMKGRKNIYGNVIHAHLKVDEGLTSKLLKDANLAFDTQPVEILHASLLHSFMKCFPDREPPLIFNEGHGREPWDSSIDISRTVGWFTTIWPTEVLVDDRKDVVDLVRRVKDGRRKVPGRGWPYFASRYLNDEGREAFNGYTPFEVVFNFHGLYQQLERKDGLLQQVPWKYEASCDNGPNVVLPGLFEITAVIIHGSLQFEFMYSREMKHQDAIGQWIRNCACSLREAVEGLIAHEESPTLSDFPLLPLTYQSLTQLTTEVLPQSGLSLADIDEIYPCLPMQEGILLSQLRNNSHYQTRTMIELISTNGSINMDRIRDAWQQVTDRHSSLRTIFVKSSLSTAMYDQVVLKSMPAQVNILPCAVDNDAVEILHRERRTFSELGKPLHLLTVCANSNGRVLADLGFNHAIIDGMSISTLLEDFKLAYLGKLPPSQGPRYSEFVTYIQSMSQQDTRNYWMNYLRTSEPCLFPVITDGISLISEEEPNSLERVEISFDCLSKLQDWCRAQDVTLSTLLRVSWALVLRCFTHMDDVCFGYVNSGREAPIDGIEGIVGLCANIITCRFDMSTTRRIADIIQSDKVDFLNSLSHQNASLADIMHEINMANQTLFNTVLSIQNKSTAGDEKSDFMVDELYEVDPTEYDISVNIEISGAGKNIDAYLGYWTSRLSQWQANNISTTLSHIVSEIVAASTLPTVGQLDYFAAAHKWQVAKWNIDEAATVNSCTHELIQTRSTRQPEAQAICSWDGNLTYRELDELSSKLATKLIGAGVKPEAIVPLYFEKCKWAPVAILAVLKAGGAFVLLDPSYPKQRLQKIYHDTNATLVVTSPHLSTGAEQLTDKVIIAHEDISTWDIDEASLKMTPVTPKNAMYSIFTSGSTGEPKGVIIEHAAFLTSAQAHTAALHLDSGSRVFQFASYTFDASVCETLSVLLVGGCICIPSERDRWNDISGAVARLGANWILMTPALARSLDPSRFPSLKTMVVGGEAITSAETHLWCDKLQLLLAYGPSECSVMCSITDPVSATTDPRNLGRVFSGSSWIVDQNDHNKLVPIGGVGELIIEGPLIAREYINRPEKTAEAFIEDPSWLYNFRWGQGSRFYKTGDLVQYAIDGTIRYIGRKDTQVKLRGQRLELGEIEHRLRRAFRGAKDVIVDVVLSTVKKTRILIGFVYCGHAETLSLDKLWDNPSEEFSLLVQEAKKRLQKELPGYMIPEMILPLASIPLTKNGKCDRKLLLKEVEAMPAESLLMLSNETLSKSMPSNAIQRKLQSLVCQVLSQPEDGVGMDDSFFHLGGDSISAMKLVGAARAEKLRVTVADIFQNPRLEDLASVLQRHSNDQAGSIEPFSLLGSDEARESIIQQVINTGSVEREEIEDIYPCTPLQEGMMALSIKIPGAYTMQHVFQLPESVDTKQLQEAWDKTINAHPILRTRIYQGDSGKAQQVVVREKFCWQQSSNLNSYLDQDRKRPMRLMEPLIRLALIKEQVDTPRQYMALTLHHALYDGWSESLLLGAVEAAYRGEELKLTPFSPLIKHISDGHEAAGNFWRTQFSDIKSAAFPSLPSENYSSIPSSFIQRSVRLGSIHRNGFTLNSQLRLAWVAVISQYTACEDVVFGVTVTGRDAQVSGIEMMTGPALATVPLRVRLQSSVNVRGNLQQIQDQFAQSIPFEQFGLQNISALGEDAAAACRFNSLLLVQPSVEDCKLDIFNHSVAVPDQSTFDTYPLTLQCTLGRDVIEIQAIFDANVLPHETMERILSQFVHLFEEISKNIDKPMGTIGLVGPEDMRMLKEWNGKPPQKQDLLTHELIQRQCEQQPNAQAVCAWDGDLTYGQLNELSGQLAAYLNRLGVGTEMIIPLCFEKSKWTTVAMLGVIRAGAAFVLLDPSAQPVQRMSDMCQQVSASLILSSAKYASCLQQLSYQIVTIAEAEPIWTTDISTWRPPSISPSNAIYSVFTSGSTGKPKCITIEHLGFASSADANREILGLGSKTRVLQFSSYSFDVCIENNLTTLVAGGCICVPSEADCKGDLAKSAREFKVTYADLTPSVARILQPEDMPTVEIVILGGEAMASEDIARWSKKVRLVNAYGPAECSVTSTIQPDAGHQASPANIGRPCAARCWVVDRHDQSRLLPIGAVGELIIEGPIVGRGYLNNATASEAFIEAPGWLSTIREGESYRMYKTGDLVQYNSDGTLTYIGRKDLQVKLNGQRIELGEVESHVRRCFRASRDVVAQVVIHSQLGNKPRLVAFVWQGHEQNGIVKGEEPSLFESPSDQFRADVKLAEEKLRQSVPNFMVPTTFIPLSRLPIAASGKTDRKGLLAAMQALSREDIQAYSPVRERRPVSTDMERKIQAIWAKALKMSPADISAGDSFFQLGGDSITAMKVAAAARTEGVFISLQDLFQNAPLEKLAKAGEVKIDVADEPIDWKKEVAVCPELEMPLSRFSPRQSSGDKIEVVLTGCTGLLGNEILKQLEASAEISKIHCVAIRAKGTGVARNGNLNSEKVVTYTGDLSLPRLGLSKEDEETILARCGAIIHCGALVSFVQGYQTLYGPNVASTKELARWAMKRFIPYHFVSTAGVGHLSGADFFDQVSVSAYPPPSDGSDGYTASKWASEVYLENVNEKFGLPIYIHRPTNILGTATSQIDVVNNLLTYSRKMKIVPRFINWTGYLDLINVKYVASDIIESVLKLGPASSPSCTGRYKLEFIHEGGEIVVPIQQLGEYLGKEAGGAAFETVTLDEWVARANESGINPLVSEYLKDLRDQEIEVSLPLAKCNRTMEALAKLNMDVGVNGTNGTNCTSTKGTNGVNGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKX0</accession>
    <name>D4DKX0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018148.1">
        <property type="nucleotide sequence ID" value="XM_003018102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKX0"/>
    <dbReference type="GeneID" id="9579438"/>
    <dbReference type="KEGG" id="tve:TRV_07844"/>
    <dbReference type="HOGENOM" id="CLU_000288_88_1_1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="131"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="684" mass="77310" checksum="18169E581F1BF1EF" modified="2010-05-18" version="1">MGRGPVPKFQSIKCISELQPRINKQPAFRRANPEGGFISPLQALTTHLPATYRICNPTFKYESSRNPRRVLTKPSKGVKNDGYDNDDSDYILYVNDILGSEEANHKYDTLDTLHTSNPQQHTDSLSTRNRYLILDVLGQGTFGQVVKCQNLKTQEVIAVKVIKNRTAYFNQSMMEVSVLDLISSKLDKNDDHHLLRLKDTFIHRQHLCLVFELLSVNLYELIKQNQFRGLSTTLVRVFAQQLLNGLALLNKARLIHCDLKPENILLKKFYRSPEVLLGLPYSSAIDMWSLGCIVVELFLGLPLFPGSSEYNQIARITEMLGLPPVWMLENGKQAGEFFEKTQDEFGRQSFRLKSMEQYSREHNTKEQPSKKYFQATTLPEIIRSYAMPRKNMKQAEIDREMNNRVAFIDFVRGLLSINPLERWSPQQAKLHPFITQQKFTQPFVPPVHLKSSVINKSVAPGVQQQQQAEAASKQRAQAAQAQAAQAQANSAAAAAAQSAYALQMNQFNAPHNQPPPVYNNMYNSQQQQQHPAPPPQQQPQQQQGPPPPYPTQQGYQMPIMQSGHMSMPPQQTQYGSSQNLYAQATTRAGRQRATTMDQQQSGIPPSIQRVASHLDPNSPIRLQPSPAYYPPPADGYPDASGPGQRRTSRARNNGSHGRNRDFIRSLEDGALGDGFMNQNQNQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKX5</accession>
    <name>D4DKX5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018153.1">
        <property type="nucleotide sequence ID" value="XM_003018107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKX5"/>
    <dbReference type="GeneID" id="9579443"/>
    <dbReference type="KEGG" id="tve:TRV_07849"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="676" mass="73788" checksum="D78FE3C98117BB1F" modified="2010-05-18" version="1">MLASRICRAAPRVPTQFIRSPAFRVPSTQFRRWNSTEGGEEKVKGQVIGIDLGTTNSAVAVMEGKTPKIMENSEGTRTTPSVVAFTKDGERLVGVAAKRQAVVNPENTLFATKRLIGRKFTDPECQRDLSEVPYKIVQHTNGDAWVEAQGQKYSPSQIGGFVLQKMKETAEGYLNKPIKNGVVTVPAYFNDSQRQATKDAGQIAGLNVLRVVNEPTAAALAYGLEKEQDRVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTHLGGEDFDITLVRNIVQQFKKDSGIDLSGDRMAIQRIREAAEKAKMELSSASQTEINLPFITADASGAKHINSKLTRSQLEALVDPLIQRTVEPVRKALKDANLTAKDIQEVILVGGMTRMPKVTESVKSIFGREPAKSVNPDEAVAIGAAIQGAVLAGEVTDVLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADFQTAVEIKVYQGERELVRDNKLLGNFQLVGIPPAHRGVPQIEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSDSEIQNMVNDAETYRAQDIERKALIEGANRADSVLNDTEKALKEFEEKLDKAEATQITEKITALREVVAKCQSGETTITAEELKAKVDDLQTSSLTLFDKMHKARHEESQQQQQQQQPPQGEEKPKDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLM1</accession>
    <name>D4DLM1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_08095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000513">
        <property type="protein sequence ID" value="EFE37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017895.1">
        <property type="nucleotide sequence ID" value="XM_003017849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLM1"/>
    <dbReference type="GeneID" id="9583792"/>
    <dbReference type="KEGG" id="tve:TRV_08095"/>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="182"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="453" mass="49420" checksum="97631F38252AD96E" modified="2010-05-18" version="1">MSNLPMEPEFEQAYKELAWTLENSTIFKKHPEYRKALLVASIPERIIQFRVTWEDDKGQTLSHLFLPDKNNKLTLAAAVNLSILKFLGFEQIFKNALTGLNMGGGKGGADFDPKGKSDNEIRKFCSAFMMELSKHIGADVDVPAGDIGVGGREIGFLFGAYKRQRHIWEGVLTGKGNSWGGSLIRPEATGYGLVYYVQHMIKHATNGLESFAGKRVAISGSGNVAQYAALKVIEFGGIVVSLSDSKGSFIVRGGEDSSITPEEIRLIMALKDERKPLSGIASHEAFASRCEYIEGARPWVHVGKVDVVLPCATQNEVSGEEAKVLVANGARFVAEGSNMGCTLDAIEHFEAHRNEHNRDQGAVWYAPGKAANAGGVAVSGLEMAQNSQRLTWTAEEVDGKLQAIMKECFETGLRTAKEYTEVEDDKLPSLVAGSNIAGFIKVSEAMRDHGDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ87</accession>
    <name>D4CZ87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025710.1">
        <property type="nucleotide sequence ID" value="XM_003025664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ87"/>
    <dbReference type="GeneID" id="9581953"/>
    <dbReference type="KEGG" id="tve:TRV_00124"/>
    <dbReference type="HOGENOM" id="CLU_087328_0_0_1"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="16831" checksum="C115BDAF9FADB084" modified="2010-05-18" version="1">MGTSASKPARAAASAASRRQYPLRPSPSTTSTPAASQPPSQTQPQAPTTNRANTQGQEKASTTRSEAPTPGAISEEVKANPSLLTLMSRTRISAEAEADMESLGRKDHAGRRFVDVVSLKQIISMRDGQGVSEEVIETQFGLKKGTLTSLGPKGVVADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZL0</accession>
    <name>D4CZL0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Annexin ANXC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE45001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025612.1">
        <property type="nucleotide sequence ID" value="XM_003025566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZL0"/>
    <dbReference type="GeneID" id="9581850"/>
    <dbReference type="KEGG" id="tve:TRV_00252"/>
    <dbReference type="HOGENOM" id="CLU_012466_0_0_1"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="917" mass="103186" checksum="42C6616F11C6DA6A" modified="2010-05-18" version="1">MSTQYREVSPSDDERYRPSRSSKYSTQVPNDHYYLSDEHALAPTDRYSSSSKPSKSKRSSYIYDSRSDIDAAPATKPPAVAYPSPRPSRLHEPAYYSESEDDHLAYGEPYDYPLARNHHRRLRSRSGSRGRRPANPKVTYDSDSSYEYTKEYTADRRRYSRSRTRESPRHGSLFEPEQAPAPAGSSPRDEMPPMIQKTQNFGLSSTLEKLKSQLYPSSDTKDRQFDEKPSDIDLNAWAEIPECEREGYVPPTAEKQSAAAPQPHNDNHNNHSEVPNIYANLTQYYQLQQQPMVASTAPVATAPELPPRPQTSTYTRPIPSVIPGATVASPATSTTQYPSIPAARYVPPQYSQTPATVQTLGPKPEHKCATSTGHIPTKQTYSKPDVYQYSVPASQIRYSTQTPAPTAAATTTTNSNYTAPPPATAATAAAAATNPSKVQYAPAPVTQPKQPSYLEIKPRRQTVSSKPSNLNLAPDNQMKIPGSFPDGANPPASPLLEPYKGTYQSISPIQWPTSLGDDALSDMEPLNGKESRTLGRKRSKKDKKKMEDPGLELEIRRRLSTSLGPSVIKEIAPKEAQVYVYDPKDDAKLVHSALNHSKINAKTLIKILPYLTSDEILHLRGAYKNLRVMTRKGVNMAKHIKMVVPGNFGKVCYATALGQWESEALWANFWYQSSRTRHELLIESLIGRPNAEIKEIKACFRDKRYQDNLELCMQTELKADKFRVVILLALQEKRQPDNAPLNVDLVRRDVYDLHRAVTSRDGGETAMIQIIIVRGNAHLREVLQAYEMTYRENFTRAMLSKSRNLVGETLGHILNGVRNRPMRDALLIHQAITESGTGRDRAELLISRLVRLHWEPHHLERVKSEYRRKYGRFIEDHIEEEIIEVGGAGAHEKKTEWADFCVELVKSSSFHVENEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D041</accession>
    <name>D4D041_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025374.1">
        <property type="nucleotide sequence ID" value="XM_003025328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D041"/>
    <dbReference type="GeneID" id="9581609"/>
    <dbReference type="KEGG" id="tve:TRV_00435"/>
    <dbReference type="HOGENOM" id="CLU_032618_0_0_1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="652" mass="73833" checksum="FC9E2A550A07681E" modified="2010-05-18" version="1">MDKVALAIIAITSIVNGFAIKSHSYDRAVTEPKSPLSTRNIKDAADFGWVKRWAAIGDSFTAGIGAGRPYSQSKSDRSCSRYDLAYPAVLNRLFGSVVQDFQYIACSGDRSVQIYEQAKALKGDLNLVVLTAGGNDLCLSKIITTCIFLPTYSEESCQAVLDKAQTNIDTILKPNLKSILKALNDKMKKDGIVVFNKYAQFFNTEDEGCTKDQSWSFPQIPSAFWLPGLFLKPLPLTIERRKKFNTLVQHINKATEEVVEEISKDSGIGYSIATSDWDPWPIRVSGQFCQPGSMGYYPDPKTKELQFFKPDTHKRSFLECLITKREEPDANEIERRRKLELESIYNSLLYKSADPRNEVLHKLGARAPDPPGCPGDGSFDWTFGFGLPDRWGRFFHPNEKGHETISAFTLETIVYLRSKQLGLLQDFCSAKSEFKCWQKEGRKAYANPDRMNENYKTFCNGIKAPDNTINWRKSQTFHEGTPDEHTFELRLSNGAQKYVKEDCLFSFNRIINGCDGNDANNPMNWKFGGRWVRGGYTYEINVKRENRPWPPIKKPHGSCEGWYKAVYSDYKLHGAGWSTYDSGRQTILPSIKGCLGLGVTAFKFKYFDEPDKDGMEWELKFHTPIWVRARCFDNNKVAFSSGGFTNGCVGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0G9</accession>
    <name>D4D0G9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025248.1">
        <property type="nucleotide sequence ID" value="XM_003025202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0G9"/>
    <dbReference type="GeneID" id="9580740"/>
    <dbReference type="KEGG" id="tve:TRV_00564"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001014">
        <property type="entry name" value="Pre-mRNA splicing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001343">
        <property type="entry name" value="Pre-mRNA splicing factor, putative (AFU_orthologue AFUA_8G04590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000698">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="6">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="57608" checksum="8F2CBAFE14E19A83" modified="2010-05-18" version="1">MHPARRAYVEEAQELSLIAVDHDYELPSAAAGIAPEKASAILSQFERKRRAAAIAVPTDDGRVKARLRELGHPITLFGEDSTDRRDRLREVLADLEEQQAAAGEAGAEDVGMGGMEAEEEDQDQEEEFYTEGSQDLLQARREMARYSIPRAKARVERQKAESTIPLRTHVKHRKAIREKLGHFELYGSQIAGDRPVSITRFSPNGEIVAAGNWSGGVKLLTVPNLEEKANLRGHTDRIGGISWFPGATLPESNVSESSLNIATGGAEGNIRLWSLDKDTSIGTLSGHSDRVCRVEFHPSGKYLASASFDTTWRLWDVQTNQELLLQEGHSRGVYALGFNTDGSLLASGGLDSIGRIWDLRTGRTVMILEGHIREIYALDWGIDGHRILSGSGDGWVKCWDLRQVRGTGGVGAHKSVVSDLRWYKGSDAASLLPTTSGLDQNGDMMDVTPTPTKDQPDQPPQPKKSGTFFVSSGFDKNVNIFSADDWSLVKSLQGHSGNVLSTDISTDAKWIASCGHDRTVKLWGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Z4</accession>
    <name>D4D0Z4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025082.1">
        <property type="nucleotide sequence ID" value="XM_003025036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Z4"/>
    <dbReference type="GeneID" id="9580562"/>
    <dbReference type="KEGG" id="tve:TRV_00740"/>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="753"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="871"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="831"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1178" mass="129935" checksum="D2A428C6E6BA1203" modified="2010-05-18" version="1">MGNVQSHCKSSIPSALYLRDQRKFSISSLVVTNRSGAVLLVISPNGYPASQISAKRDAGDNTPIEFIQDPDPPFNPLNNSQGPSFILRLTNEDELHFCFTFVIRQEKGTAAPKPTTVNGVSSALPSGIDNTVKSLTFAYAANAKDLDNLVTHEFHADPNIQNNNENVRHIGTFNTGGSPSVQFDWSWKWKPPVKIEEKCGGWRNCCSFLDYDERSNRLNTLAWFQYWVQGPPRPSTSPSFESTGFELAVPQRNRQVSSHSNVSRTSDPNESNDELAPAAPTVEYQDCFRRFTAHNSNNAVQNVQPSTSALGGPKVDVTCHHPGEDMCAVDDGPLFRATMKSLEQKTGNLRTRMKKLLKKAEVAYHARISCHDAIYNFIKTLGDTAKANAPAIQPALDHYFNRAGRELLAAERLDAEYMHEFVVKPLSRFYHVDMKQADAKKKEFDDESRDYYAYASKYLGQRQDSLKEKKRVESDSKYQMKRRKFELSRFDYSSFMQDLTGGKREQELLASLTQFAVCQANAHISTSRGVEAFLPHLDALVDEVNKVDKEFKTQRTEREEKRRLLENSSKKYIEPDTAQNPGPSPPTPGGNSTTNNNATSYTSDSDLGHADGTNSTFRGYSGNTSGRSNSPNGGATVPTGSNTGPVSSTQNRFKGFRDLEERDSTSKAATEGANGQQKKEGLLWALSRPGSHMDPKGINKQAWHKYVSFSPFFNVPIFRISNAIDRFWIVLDQGKLSEYSNWKQKLDLHMDPIDLRMASVREARNAERRFCFEVITPQFKRIYQATSEQDMGNWITAINNALQSAVEGRVSTPRTKQTTPKEKLSGRTIGSALTGKSVSPSNSNNMGRRTTVGARPGYMRSGSHGYDDDPAKLLQTIRAADEGNTWCADCCSTSKVEWVSINLGIVLCIECSGIHRSLGTHISKVRSLTLDIHSFSNDIVEILLQVGNRISNMVWEAQLSPGVKPGPTATREQRLKFITAKYSERAFVRVVSPESPEYNSPVETLFNAIEMNDIQGVLYAIALGVNVNAIDTNRKTNALTAALDSADPAPAISPPASPSLGRQRPFIPSRSSSASAIAKPFPIAELLVQNGAIMPSKLPTSPLSESAQLYLTQRNVRSSRLDGGGSSTGDTLSALPTIRGLEGNGSSMPAVDSKERERLHKRGSAGARFAGKVSAFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D123</accession>
    <name>D4D123_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025111.1">
        <property type="nucleotide sequence ID" value="XM_003025065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D123"/>
    <dbReference type="GeneID" id="9580603"/>
    <dbReference type="KEGG" id="tve:TRV_00769"/>
    <dbReference type="HOGENOM" id="CLU_734015_0_0_1"/>
    <dbReference type="OrthoDB" id="4173803at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41246" checksum="DD0D0252873EE8D8" modified="2010-05-18" version="1">MVLTAARAFNPEHLTRSETQLPSYVETADPRRPRQTYADVPPEGSPGHPANGNNAPTEPRGSGIAQPVSAETGSTSFRTAAAEAGSSRNFWPTPSAGSSMSLPNIPGTAGRVESSVDITYPLRSASADARGPRDVQLASTEAGGSRGFGNTPTTAGNLRVVNSLQTTPVEAGSSRDTQSSPAEAGDSSRFQSNSATAGSSRDVNTLQTTPAEAGSSRDIQPAPNETGNPENTDQSAQQRRPEEGSNPQTEPDPQHPSRGVPTGWLDSLFVVHLPLVHTCFGNQRRMHRVRRTIYPSYVSVGMVRQLPRLQTQRHDRFEWLFTVSARPQSRFLFPRWLKNLYIGMPHLIKDEPGEFMRMLTWRRFNPGIPRKRSLIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D130</accession>
    <name>D4D130_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025039.1">
        <property type="nucleotide sequence ID" value="XM_003024993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D130"/>
    <dbReference type="GeneID" id="9580546"/>
    <dbReference type="KEGG" id="tve:TRV_00777"/>
    <dbReference type="HOGENOM" id="CLU_142946_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="123" mass="13473" checksum="BCF2F7A3C2D8319E" modified="2010-05-18" version="1" fragment="single">LTNFSDLPWLRWARPNFSSKARQGKAGQAGFKGRQAGGGSSSFSVCFAGILRRARPVLAWSRASFPAFFARYIISPEHETCLYRSSLTLFDSPASALLLRVSIALATVVISPSFPPFLYIPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L8</accession>
    <name>D4D1L8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024894.1">
        <property type="nucleotide sequence ID" value="XM_003024848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580385"/>
    <dbReference type="KEGG" id="tve:TRV_00969"/>
    <dbReference type="HOGENOM" id="CLU_001569_0_0_1"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1446"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1607"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1624"/>
            <end position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1636" mass="179051" checksum="AED4D06337551617" modified="2010-05-18" version="1">MAVLLLASSSFASVFFGFSQSRSLHLLLFSRHIPPAMEDSNDSMHSRMRLEQLAAGMGVYMNMKFPRITRKDTVSSFSQQDKDAAEALAKQKRLEAFSAKSHVFRRTPSKRSFKREELYSAIDTAIRDDASLGMLEYLLTQLKETKAKKSFFKTQENSVALDMTDLLRLATEKRNSSFLEILSPHVDQWGLDAALGLAVASLDLHCIKALLQNGADPNSCHQQFVTAVGNGHVAVVEMLAGTEKKLSSSCLDEALPVAVSIGSMRLVMCLIHNGANADTDQILETAVQAGRLDISAALVLASRPPSRISLDCAAGAAYHSNNLSSEERDTLLELLLCAGANGDCVSRALVSAVVANDKRSVSLIVSYNGDVTYNSCEAIIAAIKGGNLHLLDILFKGAIDPDSASTALSRVPEVESNLSPTKKIAIIAHFTKCGAHGSPLHQCLVDAVHKNERSLIDLLIQNGASVDYDEGHALRLAISAGALPIFRKLMEGQPSQATLGHCIGLLPSLQPRLQFTVAQDLLAAGAKGDAVNKILIGAVMSEFPAEREQLIELFVNHGANVDAQNGNCLVQAVKIGDVVVLKLLLQGRPSSSSLSRAVVPAVSLRDRILRFSILDLLLGSKEASGPQINQELVTLLKENSLDIVAVNLFLEKGKADVNFNNGEPLKQACRMNDPELLKILLQHQPSVDALNASFSVALTSQDTSARYKMCQRLLVAGANGEALDAGLVTAQQSSPADPRLIELLLSFGADINYNGGAVIQRAIDNSDERQLALLISRFPTTLTVTLGLERLLKIDTKKRNEMAKILLDASQNRIPEALDNLLAEAILVNKGDITFLKMLIQYGASVNYQQGAAIINSIKGRRFDVFKLLLEQQASQGALEEAFKACWALKGADRLSYVSRVLKGGYKGELMDSALLEVVQEMPCSHEAIKLLLKHGASVHYNRSHSLVHAAMAKDTLTLGLLLEAISDRAGVTYAFGKLISTDTSNWITEEGYSTVELLLQNGASGEVLSLALIAAIETSDSNPKSSSFVELFLQHNANVDYQDGRAITASIAVGKPHLTKAILKSSTSSQNINTGFLCIFSSDLTEDVAVELFDIFTKTDLDIQAMNGNIWSPKDGNELREPITFQCLRKWPRGYKMLGRLLEAGIHVDALIPYVIDEEHGFEQVSLLLWALLQPQQLISPYVFECLLKNGADPNFQSTSSMMTPLLVASVDRSPDVIRKLIQHGAVVSVMDRHGVTPLVNASKRGQLTTMRCLIDAGAMIDDGSLHEASRELQSSAVQLLLDHGHNPNFPSMLHDGRCALAELCFKAESPGTSLVKTRQTIDVLISGKADLAIQSQGKPLIYHAIDNPTSCISTTTALLASKMWRLINNDFNHYTCDGYVYSPSTYVSKCLAQSPSEHAPELLRILKANGCKDVFYKCEGPQPPDMVGAPAEVIAEEKRRKNRLQRMQEQEEDHQISLQRERDAADQQHQIMARTHQLRALHDRETADERDAAAERSNRLQLRLEAETAAQRQRFAAQQQLADQEQLRMMNQLRLEAAERQGRLQIENDKIMANTQHSLLEAKMAVESRRIKELEAANERQYHRDSDLLSRQERILADRKAFMVASPSASGVDESGLPTPEPQRQLTYTGSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1N4</accession>
    <name>D4D1N4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024851.1">
        <property type="nucleotide sequence ID" value="XM_003024805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1N4"/>
    <dbReference type="GeneID" id="9580342"/>
    <dbReference type="KEGG" id="tve:TRV_01016"/>
    <dbReference type="HOGENOM" id="CLU_013615_6_0_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF447">
        <property type="entry name" value="FK506-BINDING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="166" mass="18351" checksum="0E6F6F01EB97538C" modified="2010-05-18" version="1">MGVTKTILRSGNGVDRPTKGDEVIIDYRGCLYDPSRSTYHNMGKHQLMHVRFVSRFDSSKDRGEFKTPIGIGKVIRVQQAFPMSKSLTSAFYCTGWDEGVMNMTVGEKCILTISGDYAYGDRYGLFPSLAPIALFSQGHPLLALPPFICPAPSLAVRQDNKRKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1P7</accession>
    <name>D4D1P7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024825.1">
        <property type="nucleotide sequence ID" value="XM_003024779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1P7"/>
    <dbReference type="GeneID" id="9580334"/>
    <dbReference type="KEGG" id="tve:TRV_00990"/>
    <dbReference type="HOGENOM" id="CLU_1448712_0_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="187" mass="19914" checksum="3ACF09BF6CCEC0BA" modified="2010-05-18" version="1">MSWLMTVDVYPMPTLDIFGSNSCVIAIEADDPLGSTTDRTPLTGNISSSSAAGGASRNPVSSSYLTSSIPGEDRRAPQNTIDESVWDTLSRDLLAVWEKMRQVLWPQYLLGGMMMRGGGGSGGSAERGEATGFGSESIGALRGLVSRLPDADVVLQGGMSEGLRNWDLWYGFLDPLIASILPLANVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B1</accession>
    <name>D4D2B1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_01214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="14">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024645.1">
        <property type="nucleotide sequence ID" value="XM_003024599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B1"/>
    <dbReference type="GeneID" id="9582820"/>
    <dbReference type="KEGG" id="tve:TRV_01214"/>
    <dbReference type="HOGENOM" id="CLU_015631_0_1_1"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE44034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="363" mass="41560" checksum="31C7F890AE4FBD1F" modified="2010-05-18" version="1">MLLGCAVGTWIYGAEFPLWTFLWENHLQVVTANLIICVSLAVFVYLRSFTVPAPGQHNPMNRELAPGGQSGNIIYDYFIGRELNPRIILPIPFVSENSRTLDIKAFCEMRPGLLGWVIMNLSNIAHQYRINSGNVTSSILLITAFQAWYVFDALYMEPAILTTIDIILDGFGFMLSFGDLVWVPFIYSLQTRYLAMYPLQLSPVNVALILGAQGVGYSIFRGANNQKNRFRTNPEDPRIKHIQYIETRSGSRLMTSGWWGMARHINYLGDWIMAWTYCLPTGMAGFAMVESLNPITGMMEKRAVQTEESRGWGMVITYFYVVYFGILLVHRERRDEDKCKRKYGEDWAKYTSRVKSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2K3</accession>
    <name>D4D2K3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024478.1">
        <property type="nucleotide sequence ID" value="XM_003024432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2K3"/>
    <dbReference type="GeneID" id="9579700"/>
    <dbReference type="KEGG" id="tve:TRV_01308"/>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="806"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="170"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="854" mass="96128" checksum="2F855E640757C1D2" modified="2010-05-18" version="1">MGKKRNSKKGSKGGSRGTRPANYSSTLVRENENYEKYYNSLQIVPEEEKQAFWDALRRDLPNSFRFTGSRSHALALQQRLKDFYIPNITSIRYEGELVEPPKPVPWYPEQLAWSMTTPKSVVRRFAPFSSFQKFLVSETEVGNISRQEVVSMIPPLLLDVRPGMVVLDMCAAPGSKSAQLMEMIHAGEEERMAKISQKLETTDETTRQNGVKVTDLLDGEPEAAELETAEDDGRSTGLLIANDSDYKRAHLLIHQMKRLNSPNLLVTNHDATVYPSIKLPAVSADGQPAKNRYLKFDRILADVPCSGDGTTRKNFNLWNDWNPANGIGLFATQARILFRALQMLKVGGRVVYSTCSMNPIENEAIISHVIDRCGGSSKVEIVDCENQLPELKRRPGLKTWKIMDKTGRIYENWAEAEEEVRKLNPAASRLVEGMFPPSGDADVGDLTRCMRVYPHMQDTGGFFITVLEKKREIKVKPDAAKAATSTSTGTPQAGTPAAAASDSAAVEKDVEDELLVPENSSAAEAKQDTTETTLKRSFDGLEEPQAKRPKVTESTQEEADKVSDVKPVQSEITEMPPSSTVAPAKPKRKQQTSFEEPFKYLDPNREDLDEIFKYFRLSPQFPRDRFMVRNAEGRPAKTIYYTTVLARDILTENESSGMKFVHCGVKMFVKQDVQKPDVCPWRIQMEGLPVIESWVGMDRVVKMYTKPTLRKLLVEMFSKVNDGGWKELGEIGERVRDMEMGCYILRLEASDREDGFRERMVFPLWRSAFSVNLMLPKEERRAVLLRLFDDDTPLVNSTQKQEAAKAKAKEEINIAEYESEPEVNGKEHGEVEAEEMDADPEAEAEAPVAVQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2M6</accession>
    <name>D4D2M6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_01332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024501.1">
        <property type="nucleotide sequence ID" value="XM_003024455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2M6"/>
    <dbReference type="GeneID" id="9579724"/>
    <dbReference type="KEGG" id="tve:TRV_01332"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="371"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="699" mass="76405" checksum="C614F689E94EEBC1" modified="2010-05-18" version="1">MGYSEVDQKAINTIRILAVSTPYSRYNRFLSGDVDATAVPNSGHPGAPMGLAPASHVLFNKFMHFNPKNPHWPNRDRFVLSNGHACVLQYTLLHLFGYALSMDDMKAFRKLGSITPGHPEAHDTPGVEVTTGPLGQGIANAVGLAVAQAHSAAVFNRPGYNLFDNYTYCIFGDGCAMEGVASEAASAAGHLKLGNLICLYDDNHVSIDGDIKCAFTEDVCARFESYGWHVQHVKDGNHDLEGIEAAIQKAKEVTDKPSMIKVTTTIGFGSLLQGTGGVHGNPLKADDTKQLKQAFGFNPEETFVVPREVYDLYHRRSAEGAAKEKEWNDLFAKYAQEYPKEHADLKRRLSGELPEGWEKCLPVYSPSDPAIASRKLSEAVIEKIYDVIPEFVCGSADLTGSNNTRWKKAVDFQPPCLGIGEWSGRYFRYGVREHGMAAMMNGMAAYGTMLPAAGTFLNFVSYAAGAVRLSALSGVRVIYIATHDSIGLGEDGPTHQPIETLAHFRALPNLMVWRPADGNETSAAYYSALTAKSTPSILALTRQNLPQLEGSTIQKALKGGYVAVEAENANITIVSTGSEVGICIDAAKFLKEKHNIVARIVSMPCFEVFDTQDKEYRLSVIPDGIPSLSVEVMSTLGWERYSHEQFGLNRFGASGPYKEVYAKFEFTPEGISKRAIATIDFYKGVTVRSPINRAFQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Q0</accession>
    <name>D4D2Q0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01356</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024525.1">
        <property type="nucleotide sequence ID" value="XM_003024479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Q0"/>
    <dbReference type="GeneID" id="9579748"/>
    <dbReference type="KEGG" id="tve:TRV_01356"/>
    <dbReference type="HOGENOM" id="CLU_017787_1_1_1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="241"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="309"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="607" mass="66893" checksum="04D0BC072F3ACDAE" modified="2010-05-18" version="1">MPPSGTSGLYGAPIEYIQDRLYLASYHSPPSENTPFPFLAAPPKSPSKRRAGASTPSRKHQAKAPVYFNIDGLLLYNSFHADFGPFHIGHLYRFAVHFHEILGDPENADRPVVLWTKPDSRSRANVACVVACYMVLIQSWPPHLALAPIAQADPPYMPFRDAGYSQADFVLTIQDVVYGVWKAKEEGLCGLKDFSLEEYEKYERVDMGDFNWITPSFLAFASPQHSPTAVVPQNTPEFAALPSTIEQVQDSELPVPFKNVLTHFSTRNVGLVVRLNSELYSPSYFTALGINHIDMIFEDGTCPPLPLVKRFIKMAHEMITIKEKGIAIHCKAGLGRTGCLIGAYLIYRYGFTANEIIAFMRFMRPGMVVGPQQHWLHLNQGSFREWWFEDQLKEKLSLPTPTTPGRVSSKQRLNGSQTATPPHGNQAKRAALGEIDTNESVNGYADENLPAPTPGQPRKSHRKDSRHHPYARTPSASLGGAAASPRRGLSRTHSNNRADSDEEIQALVNRVTSPRTPVSSSQRSLSHSAALTPEIDIHEDVENWVGDSGSPKPKTPSNTKSGSGVLGVSKQRSNPRRTADSRAESRGVRKSSGRIGSAGNIAKAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D310</accession>
    <name>D4D310_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024400.1">
        <property type="nucleotide sequence ID" value="XM_003024354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D310"/>
    <dbReference type="GeneID" id="9579622"/>
    <dbReference type="KEGG" id="tve:TRV_01467"/>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="487"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="713" mass="81593" checksum="2BCC0CDEC3A469E8" modified="2010-05-18" version="1">MGLNVSEAIWRWRCRTFGTGDKIKPRSQTRNTANAPEENVQGADALIKILYEAKDSREDNRRWVDYPPKQLSKSVSKAQDRAAIKVYKIVDPDKPVISGRPTLKYFKITVQSPLLVAALKDIVEKDEIYLEKTEAAEFTTPFAPLYFNADEIAALLKDAGKDTPFREHLELLLTLMDDMFAETRSRIQPLQASGLASFNLLWAYFPTGSPVYIWEGDCEFLGKVINTEIIKCNSRQIMRLRCKIMKFDGQDYVWDEYKGVICAFEGNIPITDLPFYPLNFHDDPEAVKSRLIKRARKSLDYQRLSYGSYTGVALYKSKDGMIKHNVDGRILIDVLGYNKHHEAQRNPENGVENPIKRKTRILPTDKDPETEKFMLHITGPNNASLTGGVKPRTTKHISIEDQERNKKGILGLGDEMMYMCPFLEGFALKNKEWLNFYVEDIEQVKWNDEAYDHLVYDEQQKDLILSFVEHHYSSMKMSDDVITGKGQGLNILLSGPPGTGKTLTAEAVADRCRKPLFYLQAEDLGIQAAELGNNIKKVFELALEWNAVILLDEADVFMAERNPNDIHRNELVSIFLRELEYYRGVIFLTTNLYDTIDTAFRSRINLHLLFKSLSPSARLQVWTKFLSRLPPLPATAGRKEEKSALGDLNEEDLKELSMWQLNGREIKNAVKMVKSWCDQKGYDMTLSRMESGIKVSAPQATKRDFTKPMDLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D355</accession>
    <name>D4D355_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024314.1">
        <property type="nucleotide sequence ID" value="XM_003024268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D355"/>
    <dbReference type="GeneID" id="9579472"/>
    <dbReference type="KEGG" id="tve:TRV_01512"/>
    <dbReference type="HOGENOM" id="CLU_614215_0_0_1"/>
    <dbReference type="OrthoDB" id="5416073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="53915" checksum="DA0B5B714C093B56" modified="2010-05-18" version="1">MHHPASRKQTGSATFPTILEMDASTPSTDQDDLEGTGPTGIHMVNDSFDTSFCRDSWADLRLLSEGIWLKCALHPNNPLEGNGDSGWRLIYSPVLESSPTFEHKSDKNHYYSQPATLRTSLDSSISPSASTSTLQSSDTSISTTSVRKKSCIANLRSQYSFTMTSSPNIRLSPAPPHSPVCSIISRSASPRAVELVQLLDHLSSFCVLDTKSPGNAVVAASKDIYSAGGRGEKFPLNINVLEEEPCPVVSGYDENGNDVSYLIIATRLITATSGECHLLLTTLLDITDFLYAATLEDLELRQNPKVCETERGILPSINSRVNLSAAEVINASPNLPDESKGNGVHRSQTPMSIGPSQTTEQLLSEFSQTTEQLLSEFSAELLYIYKDIFILARSLQDSTVYKISHVSRSLHAEGEYIRSHLKHTPTEKMKLLSESLGKNTRFDMVVNWGDYGVEKRLYCVPIYCGESRDWVCTMTDVDVPYLWRRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D359</accession>
    <name>D4D359_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_01516</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024318.1">
        <property type="nucleotide sequence ID" value="XM_003024272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D359"/>
    <dbReference type="GeneID" id="9579426"/>
    <dbReference type="KEGG" id="tve:TRV_01516"/>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="218"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="385"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE43707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="599" mass="67306" checksum="E442D9427BB2496D" modified="2010-05-18" version="1">MAASQSRQWGITPPLSSALPTPSELAENDALIAELKLQNNFEPPSETEKRFVWLIKMLLTCLGNTNSSGLVFRKQTLHLLQRVTIEFIKVVSKEKGLSQAAIDASGGSDIDTLVVAPKHVMREDFFAHFPAILEKHAPKDAIEKMTPVPDAFVPIIKIEIFGISIDLIFARLIVSSVPPNLDLKNKDLLRGLDEREIRCVNGTRVTDEILELVPQQKTFRLALRAIKLWAQRRAIYSNIVGFPGGVAWAMLVARVCQLYPQATGSVIVGKFFRIMNQWSWPQPVLLKHIEDGPLHMKVWNPKVGSQLCFFFIPRALADFSFQIYHGDRFHLMPIITPAYPSMCATHNVSMSTKAVILRELRRGGDMVDKIFVGQRRWSDLFARHSFFSADYKYYLSINSTSTSKEAQAIWSGLVESKLRHLVGALDRKSSIEIAHPFPKGFERVHICKTDEEVDAVKAGSMKYQADDTKTATTDETNDPTHIAAAENANENVGIAEAEKPTGENKYTLYTTTYYIGLELKPLAPDISSDTHMFKNTCTSWAQYQPGVNDLNISHVRNYDLPDDVFQPGEVRPTRPKKKVVKKVEQTVSQKRNIDAVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D396</accession>
    <name>D4D396_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CipC protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024276.1">
        <property type="nucleotide sequence ID" value="XM_003024230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D396"/>
    <dbReference type="GeneID" id="9579396"/>
    <dbReference type="KEGG" id="tve:TRV_01555"/>
    <dbReference type="HOGENOM" id="CLU_143683_2_0_1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11820" checksum="42DCC5711A0E8870" modified="2010-05-18" version="1">MGFFENFSNHADAHNEVMNAPHKASLSHELIAGAAAYEAAKAYEDHVQKNGYTGKPDSHAKAKEILAGFAGAFTDRIIETKGLDYIDKEKVKYQAHEHAQDALGREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3D8</accession>
    <name>D4D3D8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024247.1">
        <property type="nucleotide sequence ID" value="XM_003024201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3D8"/>
    <dbReference type="GeneID" id="9579367"/>
    <dbReference type="KEGG" id="tve:TRV_01598"/>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="78"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="468" mass="51369" checksum="A8DA5B4CD8B7206E" modified="2010-05-18" version="1">MQPLFSPSRSLVLFSSSPTRPLTQLAAGPAFGSFTLLLFRTSPSLVSSRGFASRKKKMAPKKPVKREKVLLGRPGNSLKSGIVGLANVGKSTLFQAITKSTLGNPANFPYATIDPEQARVIVPDERYDWLCKHYKPKSEVPANLTVYDIAGLTKGASTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIVHVEGDVDPVRDLNIISEELRIKDIEFVEKALEGLSKQTRRGGQSLEMKKLKEEEEIVARVLAFLKEGNDIRKGDWGPKEVRILSPFSLATQLHMNMVDVINPLFLLTAKPVVYLVNLSEKDYIRQRNKYIPKVAEWIKTNSPGDPIIPLSVSFEERLAQLGDDAAAAEECEKLGTKSALPKIIVTMRQSLNLGSFFTTGADEVRQWTIRKGTKAPQAAGVIHTDFEKTFIQCLVFNFDVLKECGDEAAVRAAGKVLTKGKDYVIEDGDIVLIKAGAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I0</accession>
    <name>D4D3I0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024207.1">
        <property type="nucleotide sequence ID" value="XM_003024161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I0"/>
    <dbReference type="GeneID" id="9579245"/>
    <dbReference type="KEGG" id="tve:TRV_01640"/>
    <dbReference type="HOGENOM" id="CLU_005822_0_1_1"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="707"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="109727" checksum="13DAA1C818DCBDF6" modified="2010-05-18" version="1">MARKNHHGQRSESGRALPGKKLAKQKSNGHLNGLPNGFHQASSNTPPTPSTTPPATASRAEVAAASISPSVTAASSSSPYASARTLQNLDGQLENSYGSSNGGMGGVTKKETGGRVSGGAQVNGSNGHALVSSTSVGGDVAMAPNGHHTYSAATCIVAGDRLNEHFSRRADRMAPTVKKAHSARKGVNPLVLASTILKACPTSDTIAILILLLQLPPIVLTLVQFLYASMTFMLPAGVSTGTLTSNFDIFQGPAGTPSLSTMIAMDGFCLLVWGLFMWNWAKNFAIDLAHVQVAIALGAGSSGGTGGVNTFCVSMVLIVHLLRSEGIQTFLLGHLFSAKLLSPETVAKYSYLIPAEFRRQDSSSPPSWIGSLLAVHILAQAGTAMARRSMAKNRSSPRAKSSERSATDTSAAGTPTLPDISSIEPSTALSSGISSEPAQPSSSLKDAKERVSTAKKRRRQANEARRIQPFWAALASTKFTVTREYERSRNCNWYSPNAPTSEDDLDGVSPDNAFIWITGVDTSTIEFAANDFNISEDAVAEGAAYGAAGPFYVLVNGAHWAPVSLSKVTDSSKDSPIAHWRGEISGLAPDCTYTCSFVCVDTNEEVCVVSVKTPSAPVTDQVITPPVAVSPQQSLRPSSPSTTIKNSIVNAEAKLNERRSRLKRSRNNHKLHLSKVKRELDGLTHRLLSGGDESRQRQRSLQLERTIRQTEDATAGIEAQLEKLENLSGAGTELEEWNARKAVIEAETSKLKTLRQEVEDAKSNMAKAVTSSEAELASAVQKRERLQSRLNRLTAQHERIVSSTNAQDLAEREQQAQMQMAQSAIYNSYLPGAFVPKVPARFRLIPACGGDPNLFIDVEIASEPAGNIQNIFRSDLYRLNYNPLTYAGVEQNIPVEFATETSNGVEIEVEVRESLRIHMQILTPNGVPITPWYIERAAIIEDDRAIITAGGSMGMYRYAPNGMRQFLPYGTGVTSSPALAPAPVHIPAAALSHAHPHTPVHGHGNQASYVAPRQGEVIEQLPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3P0</accession>
    <name>D4D3P0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024142.1">
        <property type="nucleotide sequence ID" value="XM_003024096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3P0"/>
    <dbReference type="GeneID" id="9577139"/>
    <dbReference type="KEGG" id="tve:TRV_01700"/>
    <dbReference type="HOGENOM" id="CLU_036089_0_1_1"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000316">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="132"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="557" mass="61383" checksum="1104654BEF17EE46" modified="2010-05-18" version="1">MKVQASERKKQKEYLYSLPPRAQDGCILVISGKQQRARREPALQTIQIKGPSAEPTVKLASSTPNFLSFFFSSLLALPTTSVTSILKAISTALSSAISLFHASPSTRALARQKTASSATLSASASSKMQSKKAIHFGGGNIGRGFVAEFLHESDYEVVFIDVMDQVIENLQKSESYTVTEISSAGENVKKITNYRAINSKYNMEDVIREISTAEVVTCAVGPNILKFIASPIAKGIDARTIERPLAVIACENAIGATDSLASFIKEHTDKDRLATLSDRARFANSAIDRIVPTQDPDAGLNVKIEKFYEWAVDQTPFGDWGHPDIKAIHWVDNLEPYIERKLYTVNTGHATAAYYGYNSGKKTIYEALSDPRIKKMVDDALSETSRLIIDKHGIPEEEQRAYVNAIIERISNPYLEDVVERVGRAPVRKLGRKERFIGPASQLAERGQKVDALMGAVEQALRFQNVSGDDESTELAKILREENCETATQKLTGLEPDHPLYDRVVEKVRKVQNESSCTSTCNSTVGTQINKRLFALLANSDNWKDIPSSKGSAKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S5</accession>
    <name>D4D3S5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_01737</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025848.1">
        <property type="nucleotide sequence ID" value="XM_003025802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S5"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="GeneID" id="9577099"/>
    <dbReference type="KEGG" id="tve:TRV_01737"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="214"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="242"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="541" mass="60009" checksum="592DFF65FBFE48FA" modified="2010-05-18" version="1">MSAVEAANEPHKAFDTILVLDFGSQYSHLITRRLRELNIYSELLPCTQKIAELSWKPTGVILSGSPYSVYDQDAPHVDQAVFDLGVPILGICYGLQELAWHHGKNVAASDNKEYGHAYLNIQRHGEKGQANIDRLFQGLEDKLEVWMSHGDKLSQLPEGFEIIATTSNAPYAGIAHQTKPYFGIQFHAEVTHTPCGKQVLDNFAVKICGAKQEWTMEKFVDKELARIRAMVGEHGQVIGAVSGGVDSTVAAKLMKEAIGDRFHAVLVDNGVMRLNEAEIVRETLTKNLGINLTVIDASEKFLGRLKGVVDPEQKRKIIGNTFIEIFQDTAKTLVEESAGYKEGDKIEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLKGMHLKLIEPLRELFKDEVRSLGTNLGIPEDLVWRHPFPGPGIAIRILGEVTPDQIRIARHADSIFIDEIKAAGLYRNISQAFAALLPVKAVGVMGDKRTHEQVIALRAVETTDFMTADWYPFDGNFLKKVSRRIVNEVNGVCRVLYDVTSKPPGTIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U0</accession>
    <name>D4D3U0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024083.1">
        <property type="nucleotide sequence ID" value="XM_003024037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3U0"/>
    <dbReference type="GeneID" id="9577089"/>
    <dbReference type="KEGG" id="tve:TRV_01752"/>
    <dbReference type="HOGENOM" id="CLU_036617_0_0_1"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="41305" checksum="948D4786B5AFF803" modified="2010-05-18" version="1" fragment="single">ISAQLRSKLSWAAAKVEKDWKSNPNSKQFSLSSQTHSPRGINASIQPNGHPPSNQPPKFSGSVGERDLAAQVLKIATGHSNLRPDMPQSKPLNSSSRPYHRHNLSMGSIPSKLSYERSTSNGFHQIPRLAPPADIIPGNGPHTKRRISQNITSPKKFKVPSLSQQSSSSSVIGTQGSCPIPATPPQPHQPSFKAPSSATTAILGRHCTPTEKTIMEQDAVETLVFMGSPENSGYYNDSRPHTNPPSNSKDSFQYPPVTENTSAPTSSAPPTLGMPFSYEPRERDPLHSKRVSFAEHGGEAPYANCSRPRLEQNAGDEIDRLLDEMGDSDNEPDYDWFAHMSGARDNFSLPQQNSQWTNDQCSHPSSAICQPGNNAQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D407</accession>
    <name>D4D407_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear migration protein (ApsA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024053.1">
        <property type="nucleotide sequence ID" value="XM_003024007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582746"/>
    <dbReference type="KEGG" id="tve:TRV_01820"/>
    <dbReference type="HOGENOM" id="CLU_001023_0_0_1"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1534" mass="168596" checksum="74C78A9B8A74DC10" modified="2010-05-18" version="1">MDDPFVATPLAAVQSQREPHRYSSFDNQLLTLNSSSPSQLKRALEIHLAETDRRLEETSKLGTALVRQQQELADKLKEVEQQEDDGEIGPELREKLLALERDYNEVGRESARTTFGAKPRLLAPEDTPLDSRPASRIHDIEFATEISTSLLTQVRQLQALLAERDEALRETNLEKSRLELEAEGFSQRIRSLDESEQRYKDENWRLETQSHELMAAAKEAAARENRLTANLNALTAKKNSVQRELDELKQANGKLIEEHSAAQKAHDSELHILRRNLNTGDAERNNLRKKVDELVGQNQELAKAVAAKLRQHESEPARNVDTETKDNDDDEDTPENSPPPSPNKATPRHGHLESETLKSSLHHAHRMIQNLKSNIHREKSEKIELKRMLQEARDDLEARRNEIAAAQGSAQKRQKTKAEIFKKPPRPDMLGAGRKGITEIEFDEPDWEDEEVMEPSPTKTVRPRQTSVVYTRPRPRPRSGYVSASDAYQTANETEDGGFETAHETETATESENFQTGTEDMAGDSSDELTETEGRAVGQVALPRTKPYKLRNAKAGDRSSFMSTASTSADEDDYPYNEVHTPVQSHPPRYRLKMQRGRHARSSEETIQAGGSMGYETQSPGGSLHSPKSRVEGGRSLFAELGEAGMGSDGEFGSPLQQPNNNPVSSESTPIRNLSFLQNKDVDQPPRVAMVDSSMMTEPWPAPAPASGTVATQTLAPQTVNATTSTTSAVLVDSSTQSIDSKHPITQTEAMVVFNTLPSEPVKSVDMATQCSPVKSQPMAQSAPVVIHDTPPAEPSKFTAVDMATQYASAKPQAMVQSEAMVMFDSPPVATPAEEDRSRDTIAPMPVPLPITSSSPNPEPAPEPIKLERSPIVFEETTPVLAPVVEQPRRSSMQLAFSDVTFEQCRPVTPLPIPAALPVPCTPPKYMASSIQTIDTPPISPPTQPEVVKPSIQLEMSSIYAESTTPVVPEPAPTVVPPVVALGTGSETETSPRRPRTAVHDKDTEVPSSLESSREMIPPPKFVTEDTGSMKSEQPLRSFAPASVTENGAQTILTSKQIDSLLLDKYVMPPPKTPESRAPVPAFPGSLEEAALATPRAKTQPSSANDNFLLPNAAAKRPGSAGSRRSAMVHPPLPPDHKQAIAAAAQRLSTESPTGGAGTMGPPVAPASAYRSGVPASRPRTPNEQAMGTATVQGSNGSKTQHKHSGAASRRSSISSFASELDDRFNLSRSEYGFEPGTDPRMIQAITQTMIGEFLWKYTRKPGRPDFSQTRHRRYFWVHPFTRTLYWSTQSPQTASKAQLMAKSVAIEAVRVVTDDNPYPPGLHRKSLEVVTPGRTMRFTAATSQRHETWFNALSYLLLRANEEEGDFVLHSTPEDGPLDFNPSLNGRSSRMTDYSRRSAASHSSRAARGMARGYDITPGHESPSLSVRPPDTTMKAEQARQGSVSRLSSMFKTSGMMGTFSSRRSRYGGKRGSVDDTSQEDSAEDLRRILERQEREADKIENVRACCDGNIDLHPLLAFPFSLVLTFSFTRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D428</accession>
    <name>D4D428_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000097">
        <property type="protein sequence ID" value="EFE43391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024009.1">
        <property type="nucleotide sequence ID" value="XM_003023963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D428"/>
    <dbReference type="GeneID" id="9582701"/>
    <dbReference type="KEGG" id="tve:TRV_01841"/>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF1">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055963" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50692" checksum="CBEE2AFC2EC031FE" modified="2010-05-18" version="1">MKFSVSVSLLAAAGLASAANEFAMNRLMSMKVAEREEYRAKGMFAPGRYGNSTNKFVPCRHGKSGEYSCNKVDQHGFLTHQEMGSTTREGNDVWGWTSRDGREFGAIGQTDGTAFVEILKDGRLEYKGRLPTQTVSSIWRDMKVIDGYVYIGAESRDHGLQVFDMRKLLDLKEPKTFSIKDDMTAFFSGFGSSHNIVHHEATKMIYAVGTGRKTECAGGLFMVDVSDPSKPTSRGCANADGYVHDAQCVIYTGPDQQYKGKEICFGYNEDSLTIYDVTDKQNPKIISKTPYQGSAYTHQGWLADPKKMTYLLLDDELDEKDGTALGKNHTTTYIFDIKELAKPKYTGFYQSPAQSIDHNQYVLNGLTYQSNYGSGLRIVDVSSIDRKPDGSQFKEAGFFDCHPEDDHMNGEVSFHGSWSTYPYFKSGYILLNSIERGVYSLRYNGPPARYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D430</accession>
    <name>D4D430_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000097">
        <property type="protein sequence ID" value="EFE43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024011.1">
        <property type="nucleotide sequence ID" value="XM_003023965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D430"/>
    <dbReference type="GeneID" id="9582703"/>
    <dbReference type="KEGG" id="tve:TRV_01843"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="694" mass="76139" checksum="D7A6827366561A0F" modified="2010-05-18" version="1">MSKDTVFYPRVLKRGPFTVEAAGYEPVEGETIPRRHPSAKDELLKTPNPEIATTYDNLRWSAKTYGNSKAVGSRRVVKTHVENKKVKRLVEGVEQEVDKEWTYFELSGYSYLTFTEYEQQALQLGAGLRKLGHQAGSRLHLFSSTSAHWLCLSHGAASQSITIVTAYDSLGEEGVRHSLQQTHSESIFLDPTLLPLLRKVLKDAKDVKNVIYDTNSEPKQEHIDALKKDFDYINIMTYEDLRKLGEENPVDPVPPSRDDLCCIMYTSGSTGPPKGVPLTHGNVVGAMAGGDSIVGPYLGPSDVLLTYLPQAHILEFVFENLCLFWGGTMGYGSPKTLSDTSVRNCKGDIRELQPTILVGVPMVWESVKKGIIGNVNKNSAIVKSIFWAGMAAKEFLMSTGLPGAGILDSFVFKKIKDATGGRLRLTLSGGGPVSKETQRFLSMAVCPMINGYGLTETSAMGGLNDPMAWTNDAIGEIPAAVEMKLVDFADAGYFTKNNPPQGEIWIRGVSVAKSYFDNDEETKAAFSPDGWFMTGDIGQFEPNGHIKVIDRKKNLVKSLNGEYIALEKLESIYRSAPVVANICVYAAQDQAKPVAIIVPAEPALLQLAKSNGIQGDSIGTLVHDKKLNSIILRDMQNVGKSAGLRGFEIIEGVVLSDEEWTPQNGFVTAAQKLQRKKLVNKYQKDIDRAYGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5L7</accession>
    <name>D4D5L7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023495.1">
        <property type="nucleotide sequence ID" value="XM_003023449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5L7"/>
    <dbReference type="GeneID" id="9583515"/>
    <dbReference type="KEGG" id="tve:TRV_02390"/>
    <dbReference type="HOGENOM" id="CLU_026793_0_0_1"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="501" mass="55910" checksum="FBEAB0B6BF31E1C9" modified="2010-05-18" version="1">MSSPSRPRSQGLNRDTPTLEHGSQEEGENVAQGASHDEHPVENETEAPVVPVCHGARIVDSDDSDDVAPIMPHPESMTHELSPRELEAICLNDELSTSNIFPGESDLRKCWICYTDESEDSPLNKEWRSPCPCALSAHEACLLDWLADMENTEGPNRNQDGAMLLCPQCKSEIHMSRPNSLILDLAHKCEGMLNRLVLPGVAFTLVGTVWAGCCAHGVYSMYLIFGRETTIRLLEEAAQGPLGIRLNLGLPLIPISLMFSRTQYADSLLPVIPVLFFAAHHPYHQEMDLQLWPPSASMTFAALPYIKSAYNLLYRKLLGDLENEWISTVRTRLNADEDVRGPRRRRDFQDEPDNAEVVMEIELQMGVGAGNDGQRPAGGAHDNENGIQAHQIMAHRQGNMLRETTNLADIVLGALVFPAISAGMGGLLKWALPKTWTTPSLYERGRPWLLQTRWGRSVIGGCAFILFKDAFLLYCRYKRACLHTQRVILNYDKKTKRPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5X0</accession>
    <name>D4D5X0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1237 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023391.1">
        <property type="nucleotide sequence ID" value="XM_003023345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5X0"/>
    <dbReference type="GeneID" id="9583411"/>
    <dbReference type="KEGG" id="tve:TRV_02493"/>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056214" description="DUF1237 domain protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63026" checksum="B8C2B820F4E80931" modified="2010-05-18" version="1">MRFLEIAVLGALAYREVSAADSWATSLHARKQDIMEACPDYVAYSQTKHEGPLKLSYQRPIPECRTFSSPLVEKVIKDITSRMVDKDLARIFENAFPNTLDTTVRWHVDGTEKKKRSSKTKRAGGVWEGPQSFIVTGDINAEWLRDSTNQLAQYQKLANGDPKIKNLILGAINTQAEFVIQSPYCNAFQPPPPSNLPPTNNGQMDQVHPAYEPSVVFECKYELDSIANFLSLGNQFYEETKSKDFLTPRWYEALNTVLRVLDEQSQSTFNENGQYRRNEYTFQRHTNAGTETLSLMGVGNPLGNGTGLVRSAFRPSDDTSILGFFIPANAMMSVELKRTADTLSKVGGDKDLIQKLKRYSEQIREGIYNHAVVTHKVWGQVFAFEVDGYGSNILMDDANLPSLLALPLLGFVDQNDEIYKNTRKMILSKTGNPYYLTGSAFHGIGGPHSKLYFPCYLFPTSLLTVLVAVGLQNAWPMSVLVRARTANSDAEVMESINMVRDSCLLGLVHESVDVNRIAKYTRSWFAWANSVFAQTILDLAENKPHLIFGKGAKPYIVSSDAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D617</accession>
    <name>D4D617_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023314.1">
        <property type="nucleotide sequence ID" value="XM_003023268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D617"/>
    <dbReference type="GeneID" id="9583333"/>
    <dbReference type="KEGG" id="tve:TRV_02540"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="39078" checksum="768BC1C69BA6F89C" modified="2010-05-18" version="1">MANHCQSKLTTVGLASGHFHADEALAVYLLRLLPAYSTSPVIRTRDPGQLATCHTVVDVGGVYDPSQNRYDHHQRTFDTTFPQHQTKLSSAGLVYMHFGKAIIAQHMGLSTEHQDVSTIYEKLYADFIEALDAHDNGISVYCPKAISNAGLEKRFRDGGINLGSLIGDMNLCGPGENLDEDALFARASTFIGEAFSRKLHAASSRWLPARATVSQAHQSRMDVHPSGKIMLLENSGIPWKEHLYRLEEEADNVTAGTADNKVFYVIYPESTAEKSNWRVQCVPVSENSFESRKPLPESWRGARDSELDSIISKEMEEKQRERIPEGAIFVHASGFIGGHKNKAGALAMAAESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D635</accession>
    <name>D4D635_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS drug efflux transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000132">
        <property type="protein sequence ID" value="EFE42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023303.1">
        <property type="nucleotide sequence ID" value="XM_003023257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D635"/>
    <dbReference type="GeneID" id="9583326"/>
    <dbReference type="KEGG" id="tve:TRV_02558"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000056">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF163">
        <property type="entry name" value="EFFLUX PUMP ALNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="551" mass="58154" checksum="0AA2019B65E5EFEF" modified="2010-05-18" version="1">MVLKPDTTTSKGLDDTEKGACSCSDTHQADERSSPRDIHGTLWLIVVLGIFSSTFLFGLDNTIVANIQPAIVKSLNGVEKLAWSGVAFIMASSATVLTWLQIFNQFNIKWMYIFSITVFLAGSAVCGAAQTMDILIGGRVICGIGGVGQYVGVMNFLPRLTSLQERPIYVSAIGLTWGAGTVLGPIIGGAFADSSAGWRWSFYINLVVGGLCMPVYLFLLPSLQPQPDSKIRVMDKLKKLDIVGSLILVGAFVAGVIGLNFAGALYPWNAPGIIAALVLGAVGFIVFGIQQSYCIFTTEETRLFPVELVSWCKPVLSLIFLCGCCTSVCVTIPAYIIPLYFQFTAGDKSLESGVRLLPFVCLLVFSCVGGGILASRAGYYLPWYLAGGALCLVGSALMYTVNPGTAPGAIYGFSALIGLGSGMYLQLGHSVAQAKASLDKIPAAIAFTTTAQLNGMTIALVIAQCVFVNKAATGIAKVLPHESHSTIIDAITGTGSTFVHDLDPHTKAAVLAAIVSAIDKTYILCIVAGAATVLSTFGMKWERLFISAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D643</accession>
    <name>D4D643_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023292.1">
        <property type="nucleotide sequence ID" value="XM_003023246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D643"/>
    <dbReference type="GeneID" id="9583312"/>
    <dbReference type="KEGG" id="tve:TRV_02566"/>
    <dbReference type="HOGENOM" id="CLU_044229_0_0_1"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55276" checksum="EAEA5FA3B46D8B7A" modified="2010-05-18" version="1">MSRLHPNDHTEGSEYSFSQDPVTPVDVVQPTRKQMVGFAAQPTTMENSTRDPPSESPFADPPAKPGSSDSNKQPNVSDVGFGYVSDNRPDRDAPGSSANAPNSPLKSAMKVPGTPGRFGNANPLSPIFREEQILEIHEKDAEEENAKDLKIKTRVRLSKILLRGVNFSCSLIVLALLAQSFLIFRATRHLESRNGLTPWDPNTNPWPQILILVLTSINMFLSIVVLWNNCRGKERRAEKVNVYYTLFAGGFFVFTVIMWVIAAGILQNSKDSGNGKDLWGWSCKDNQRATLFKELVDYALVCRMQDWTLVCIIIEIVVDTITIAIYAVVFYRFYSKRKLRKSMNVRDKARSDLYLANLRVQTAPNTPGFARSPAMKQNPYSAAENGQANEYYQPQYATPVNTTTNKPFQLQPPPSRSSNSIHNAPRAETQSPALEPGSTERVNHHVAVAPGEQSYGAVPIPEPYRSPSFAPQGMTLPNTPGIGVAVLSDNASHVRNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D653</accession>
    <name>D4D653_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023242.1">
        <property type="nucleotide sequence ID" value="XM_003023196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D653"/>
    <dbReference type="GeneID" id="9583262"/>
    <dbReference type="KEGG" id="tve:TRV_02576"/>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="29767" checksum="556996418E6F00ED" modified="2010-05-18" version="1">MQWSFTFPPVDFRIQVDMENAPVHTNVYAPFFSLMIWLASTLVAVLLFRRVRAGYLEFLSLGPGGTPSTPMGYLRTGILKYLPTRTGKRPKVAGIIPHRQVTQQATPDMYAALKEEIKKLALSNSDRLYEGTSCFEKHSIGLFTPLDLPNRVTCNGEICHAHPIDGSIHMTLHPADVKFVIERGWGERHPLARDSWWWMFRLVPTGFVMIYAPRSKEELDSVVQIIHAASWWVNGIEPRWSTPANSSRCGVDGGAGFIKSQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D665</accession>
    <name>D4D665_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023254.1">
        <property type="nucleotide sequence ID" value="XM_003023208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D665"/>
    <dbReference type="GeneID" id="9583287"/>
    <dbReference type="KEGG" id="tve:TRV_02588"/>
    <dbReference type="HOGENOM" id="CLU_058456_0_0_1"/>
    <dbReference type="OrthoDB" id="4633155at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="254"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="52280" checksum="B2F453A0F10A44CB" modified="2010-05-18" version="1">MPLILDSTPPNPDIQSSAMAEDYKPLLPAIVVLNRRYLITGNSAAAKVGAAAFAASVVQAFVERGIFLGMILYQRDEDIVDPYISSEAFSSISTVTVSFNFHMDPSKVANALLNCIKILKVTNPMEGTPMLYYQTDTLMEYHPRHIPSCVTHHGPFFGSFATIFSKEAAALAFGSMEKAEHLERQQDKGIEIIKSRENAFVLQHSQLQGNFLASRGVTALRELCPPIELLTETEETKDELPENITEWFNFDGVVMFTAVARLDYFKNIDLLVDAAILLCTRGIPLRVFVAGGEQPDSMEHRALMDKVPPQYQHLFLLVPKVSRSALYSLFAVARHTGIFICPSRYETLGITPLEAALNGVTTVISNSSVVEASRFYPDEFRFSPNPEDLSKLIVQLSGPRGTLAKSGDLIRLHVGKSIQGSKFRSDLLDAWSDFSVQYLSTLVNYVPAVQPPLCLETAPQELGGGMKGQTRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6D2</accession>
    <name>D4D6D2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall organization protein/glutathione transferase (Gto3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023194.1">
        <property type="nucleotide sequence ID" value="XM_003023148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6D2"/>
    <dbReference type="GeneID" id="9583214"/>
    <dbReference type="KEGG" id="tve:TRV_02657"/>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="43041" checksum="23F5E2F96D7C5315" modified="2010-05-18" version="1">MISALRPTGFNLIYTLKAPSTPLTSAKKFLSISTRSMATGNDVKITSWVNPNDKSGEFKRGQSAFRNWISSKPGAQFPPEKDRYHLYVSYACPWAHRTLITRKLKGLEDIIPYTAVHWHMGEKGWRFVTSDENVPGENVTAEPLNGYSHLREIYFSVDPEYKGRFTVPTLYDKKTKQIVSNESSEIIRMFYHEFDGLLDDKYKCVDLLPAALEKDIDAANEWIYDTVNNGVYKCGFATTQEAYEKSITPLFSSLDRIEEHLSKTYSPSTPYYFGKDITEVDIRLFTTIIRFDPVYVQHFKTNIRDIRSGYPAIHRWLRHLYWDIPAFGETTQFEHIKKHYTKSHGQINPFGITPVGPLPDIMHKDEEVNAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D726</accession>
    <name>D4D726_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022918.1">
        <property type="nucleotide sequence ID" value="XM_003022872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D726"/>
    <dbReference type="GeneID" id="9582984"/>
    <dbReference type="KEGG" id="tve:TRV_02905"/>
    <dbReference type="HOGENOM" id="CLU_057752_1_2_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="190" mass="21289" checksum="76557CF50C49B482" modified="2010-05-18" version="1">MLDLEPENTVFFLRNLGTHSTFFSRMLEHDWKVSDGPETSISGSWEGVVELKDDDPQAIKAMLSFMYKFDYTNPATSAASFVFDAQVFAVAEKYDVEGLKFCVKDKFHASILSDWKDEDYPDVIRGVYDIPTTDPALRDTLVQVTCSNINNLIQKDGFKSALNDVPGFAVQLITRLVANNSTVARNLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D794</accession>
    <name>D4D794_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022893.1">
        <property type="nucleotide sequence ID" value="XM_003022847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D794"/>
    <dbReference type="GeneID" id="9576931"/>
    <dbReference type="KEGG" id="tve:TRV_02975"/>
    <dbReference type="HOGENOM" id="CLU_009663_0_0_1"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="675" mass="74188" checksum="4650B5FEFD9A8502" modified="2010-05-18" version="1">MPLSRDCIITSAYCPGAIVPGAVINQGEGNRSANPDITATTRIPENITEMFSSVSKKSSIAGILDIQYRFWLPYTSEYFDDHKPYPRGQLLSLESLISRDDITLVEGVIADMHSGGIGFRNHSVPSGMPFGAEWEEDILWVEPEISCVNTNLTYELTLADTRNGTFSPPIRSIELVDEGGFSNLRHGDPYEGWPNITYASPDPQLRADRSAWLNNFLAGITYNLTDGNSSAVGYGFNVTRGKHYPIAGSVPYFVTLDIQSLSPNGAWLNLPSVSFDNNGTLTVGNRTIKSADDDLYWYSIGLFSELKGRCLGQYNDASIRNEYNVECGHFFGAASRVDEGNPLFKEAGSKWRKPIYTCAGAVKSSVKTVSFVMNGTASLESLSVKKIEDKKYSSSDDHPLWALEDWWHPGSEGAFTGPLWGIVDNSYKGTPGYNFTRAPSFYLPFSYYSLTLSSFSGPLDNLAGASMPYGIMGKLLLNNFFGRFSDDYISYSGASNVGLGNKWRNLSKTADDASKLLRLIWTDIMASNTVGTNMRGSTSVEKRATGDGPFTQTVRAYERKVTYDLRFAIPAIFFLLSWLLLLLASLVMAVSDGHPFTRLKKLLNDTSVGRIAASSEYPESRSMHDASTKDWLAAAGHLPVRLSGLSKVSATDELEESGKALYSRLLRPALSDNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7G1</accession>
    <name>D4D7G1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022819.1">
        <property type="nucleotide sequence ID" value="XM_003022773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7G1"/>
    <dbReference type="GeneID" id="9581543"/>
    <dbReference type="KEGG" id="tve:TRV_03043"/>
    <dbReference type="HOGENOM" id="CLU_043857_0_2_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="180" mass="19705" checksum="7EDE13DC3AE21C69" modified="2010-05-18" version="1">MQAETRSSSSSSRQTETPAEMAARFPSYLQGADKGFTGRHGRAYLVADPKAPHPALSVLANTVAHRAVPRQLVTGSHTVSDIACRFCHTVLGWKYLAAEEESQKYKVGKFIVESKRVSVSRDGPVDFSHAAAAAAVDNGSGKKEEIEFDSQDEDECEDLFAGVWTPSLAAKRRQRRKHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7T1</accession>
    <name>D4D7T1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022704.1">
        <property type="nucleotide sequence ID" value="XM_003022658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7T1"/>
    <dbReference type="GeneID" id="9581362"/>
    <dbReference type="KEGG" id="tve:TRV_03165"/>
    <dbReference type="HOGENOM" id="CLU_457069_0_0_1"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="561" mass="63689" checksum="2AF4C7858092ABAE" modified="2010-05-18" version="1">MDYLSSICRNFTAFITLQNIPYQNQKINTVCEAIPRNRLIHTMLSPPSSGRLRRNRQPLKAKVNKYQSLVPLTPETPSAGRKRRTVQKGEFGQNHGRTANSDDGGSSLIDRERPSKRLRIYLRPPKPSLQKGFCPSSGYDSELDGSTLIEDGQGSKAKSSLSRDDLSTSASDTSSGSEDIESSVSLEDHQRVFDEATEVEKDKTDTPVLQTPRSKQHRKRNPSQRLSNAEVYRPSPKIVDKNLLKQIVRRDAHESDLSEEEIYGSKYSTKREIKRDLDIEFCMEKARRWAAAVEGPSGNWADAERDMYFRLAMRGFEPVLPHSWKMDFMTLPGSLFKPVNDHTAYISSRNDFRGMKYFNNLITLGGRVRDRITCHLPPEKVVKQYLCTYLQWTLRDIDMQKRPRFTPPYSVYTLKPNQTTRDAVNIMNSKLVAVAKNYQNAWRLTPSIESDDGADDHIEACPQYQDRTFPVITGYLICGPVVVLMTLDSDPETFPTLDAKVSGRLMSRFDFSEYGQDVWNALAIAIAAARMRKTIAQCEQEGTGDVMWMADSVSDPPDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8C7</accession>
    <name>D4D8C7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">TRV_03363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022521.1">
        <property type="nucleotide sequence ID" value="XM_003022475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8C7"/>
    <dbReference type="GeneID" id="9581097"/>
    <dbReference type="KEGG" id="tve:TRV_03363"/>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="348"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1247"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1269" mass="140813" checksum="9E656B4717CD3212" modified="2010-05-18" version="1">MDQQSKGPEHSKEVPDDTKPENTSQELANGNKTEGEQDDNNNAGDQRKAPSRATQHSGYGRSILASVYISSLSGLPNGQLQVSSQEQVQDVRQSIVELPGTFQYTCFHLETEGNRINDYVELSEVKGLKADSEVVLIEDPYTEKEARMHVVRIRELIGAAGNRVDTLHGLSAGLSLYDSVAAGEGLPEEAKKTHALDGYDVNAPLDLATVLPKDQSAVPKTVRSVSLSPWNPPPYHLRQKGHLLYLLVTTNEGEQHQITSHVSGFYVNKCSNSKFDPFPRPAPKNYSAHSLLTLISLISPSFNESFKALQEYNNKKDLLTTFPFQNSIPNNPWLVPASQSQATAHISDATRSQENYLIAGIDNSETLRDWNEEFQTTRELPRENVQEKVFRERLTSKLFADYNDAAVRGAILVARGEVASLNPMEARDAQIFVYNNIFFSFGADGVGTFAAEGGDEAARIAVGKDVMGVKTVNQLDIPGLFTPGTVVVDYLGKRIVGQSIVPGIFKHREPGEHQIDYGGVEGKDVVAKNEAFTPVFEKLSKALRVKKHAVWDKDGVRHELEGSVETKGLLGTDGRKYVLDLYRITPLDISWTEDAEGHDEYPHRMPVLRHELVEAYWRYKMGLYVKEEVEKRRAAAKETKAVENGEGGDAEKKDNSDQERVDISNFRLALNPDVFSGQVPQTEEEKEEWARDEKEVRDACDHLRSKALPELVKDLYNGEVGFPMDGQSLGQLLHKRGINIRYLGKVAQLAQEKGSRLQSLVALVVQDMVARSFKHIANRYLRNLPPPFATACIAHLLNCLLGTEVNSKPRAEIDESLRAIYPEGDFSFEEVTPASLAADIEKQVKSRYRYTPEASWTGSLKHFQVLRDISLKLGLQLVAKEYAFSKSQVKEQSPAGNGAHSDSQDEKKKKKKKGSSAAAATPAPAPALTFGPDDIVNIVPIVKDASPRSALAEEAFEAGRISLMQNQKELGQELILESLSLHEQIYGILHPEVAKLYHQLSMVYYQTDEKDAAVELARKAVIVTERTMGVDSSDAILSYLNLSLFEHANGNTQTALVYIRHALELWKIVYGPSHPDSITTMNNAAVMLQHLKKYPDSRKWFESSLAVCDELFGRQSVNTATLLFQLAQALALDQDSKSAVNRMREAYNIFLNELGPEDRNTKEAESWLEQLTQNAVSIAKRAKDIQARRRRLVNLPGRSSLTAQAQPSVGQTTSEMVAGVDGANPSLDSRSIDELLKFIEGGDAARSKPKKRTTRNPKLRGSKQTSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X4</accession>
    <name>D4D8X4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022351.1">
        <property type="nucleotide sequence ID" value="XM_003022305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X4"/>
    <dbReference type="GeneID" id="9580898"/>
    <dbReference type="KEGG" id="tve:TRV_03562"/>
    <dbReference type="HOGENOM" id="CLU_012630_2_0_1"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="646" mass="73073" checksum="C892E78177BD20E2" modified="2010-05-18" version="1">MPRPFLPPTAIRLQTTLNSALCTESTDHRSEYNDTPHPETDGQRNIKRKRPKYIREGDYRSDKRSPAVIVKGPKHGLQSKGTLPQEFNVDDLTYNRAKHANTEESKLLFGLYLGVLGKAEGTTSLKVVLSNPQREVLVPSRPCKQAGNDDLDANGVSHLISLLNQEDCGDQELFAAYRRIPSPGVSYLSSKTRGKLLHRFAKPERKGRTGVFYYLTLVDDMCDASLEMSPSLWTAAIHLAGKSASTVKREDLDAAIGVWRRMEHEGNISSSSVAFNILFDLAIKSGQFRVAERIIADMKKRKAKFSRFGRVAQIFFNGLKGNARGVRRAYDDFIKAGEVVDTVVLNCVIASLIRSGEAKLAEIMYERMKEAHERLKKNTSEKAVMYPLPSQDYSAYRKASKRLGRVLGMTSYLHDKLPDHHRALQAAMPLTPDAKTFHILLSYHAHVTGDLGRFLSLLSEMEGTLSIPSHGMVYILLFQGFAIHGSKKNTRWTYPCLQRAWLSFLRAVRDYDASIQTKPRTVNRKARFAWSTETSFVEGKEHETEATAEEVEEAEEEFKEEANRIFHGTFNDAREELEDEWKYENSVYLGRTVIIACLRAFFTCGGRSAVLGVWEQIDQLWQGNLKQRDIDAVRAVLRELVPPRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Z0</accession>
    <name>D4D8Z0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022367.1">
        <property type="nucleotide sequence ID" value="XM_003022321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Z0"/>
    <dbReference type="GeneID" id="9580914"/>
    <dbReference type="KEGG" id="tve:TRV_03578"/>
    <dbReference type="HOGENOM" id="CLU_1166571_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="238" mass="27132" checksum="FED09A841BD3A42A" modified="2010-05-18" version="1">MTKQDDDEEDEDEDDQDEDDDEDDCADGRDGRVRPPKTADRLQQASRGPSGAIERCFDDVDMSVSLSGDRYRGINGGGWRLMAASYTHPCSGLYGRQDSVSLLLANEKEVVSPLCLPPSMFLQLLAHFSWLYQRKVPPSHVTRSILAPGPQTHSVYSHARIELERVVSHLYALFFFFRPFSFSYFDPRLKLSFFFFFFNLPVLFLPSLHTISRPQLQDGLDILPMAKEAEESVTSWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D922</accession>
    <name>D4D922_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022288.1">
        <property type="nucleotide sequence ID" value="XM_003022242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D922"/>
    <dbReference type="GeneID" id="9576891"/>
    <dbReference type="KEGG" id="tve:TRV_03612"/>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="621" mass="70242" checksum="6684B03079E3A900" modified="2010-05-18" version="1">MRVEVKIPGSLESYCIDERGDKRVATEALWLETFVCGVLRSYSYADDGSGDAIKKIVGVRRFNPITNTEMEHKFLDAAERLFFNGSLSFKYVMNCVQLANGGPPPISFLGRQLSSDPETQVPNTVTNHLTSGLLKYINTTGRYVSGINLFEKLRAREVEVSSLLARVLISADEEVQAVRLMHDALKDIPMDYALLDCQAAFCQSKGEHEMALECAKRSVTAAPSEFSSWIRLAEVYVSLEKWNLALLTLNSCPMFNYQDRDSPRMPQPTRVILPVLPESLLDEIDEGQPKEGTPHDMVHPTLRKLHAGNYQGTFLKAYNLLTKIAASIGWDQLLKIRSEVFVMEEEYRVERQTATRPGSTAHNASTVALHDGASQATRTTQEDDDGDDEEDDDDGDKSENEQGASEQNGGEGGEPKQSSEHHGIEKPNQTVASEVVKSGNDDQENTNSTSQFHNKRLCERWLDNLFMVLYEDLRVYTIWRSEMAQSRQQSLDYKKSPTEWEILGELAERLHHLPEAIEAYKYCLSVRFSPKALRGILKMYERQNDTRGMLNALIRLIAWQYRWYSEFSPDLLYIIRKLIEEEGAVKVRSIVQATNLPQPILDLTHQYCQLCATFRSSGSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D923</accession>
    <name>D4D923_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022289.1">
        <property type="nucleotide sequence ID" value="XM_003022243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576892"/>
    <dbReference type="KEGG" id="tve:TRV_03613"/>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1747"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1754"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1776"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1831"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1854"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1904"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1923"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1993"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2011" mass="226437" checksum="1B8816A25DC62EE9" modified="2010-05-18" version="1">MSTFAALNIEADDSPEEEIDDTREIQIEEALKLYQTALKLHSLGPKHYKEAAEAYDALFKSEIFKLPQYTDLGADISDDGFIEEVDEPSAVSVAAVDETETAASALPQTLYLSYKNYGQFLLDTVRHAWEQGGDIADTTPSTESAIRHFADALERDDTDLELWRKCGRVGDALRSHRISRFCLESVFEGNGDGIDDGFEQLGIEQAGAVGDLRKFFTALHDPLSLAQLPQKQPRKALLNFLQRQIDPFPYLPSALKQLNGGSISCGLAFPKIKRLTVTPSANSWAALGEKLLELLSKDGSDQGTAEVQGNLQICLADSDITMASPAATLPIIQGRRPSKHKSSASTDMGEAESKPKASTEEATAKDTEMKDSGQVDEKPEPKGDGEVNGNTGEDAQDDTAKENEDENTVDKDKEEGEKSNEPTDDIEARPGPQTRKRSSASIFNEEPTDGVRTKSKRIRARESIADTQAQPEEVIFDQTRYFEDRLEVYTHADEWMFSTANDLLSKFGVEELGSIDQIKQILASTESDQDTTEITPETLAVRDLRYIVENWSDAFGKIALHSDIFADTQDGLKGVRKSGLSVFLEHSKQVGAKAEQEVDLVDNDSLEQFAESVNSSNLTIQEVAFKWLEKYLKPDLQSLGHDISTVTDSSYATQRMPQSTRDTLTQILVRLDGFVYARMREFALNLEKRILSHAHETPYSFTPDDLTAVEMSQSIYELHLDIYDSIICQKEKDQEAAVLQQDRLNRWRALTRGYISYYLDLCAVDNRQTAIVLRHLWATTFHENMLDDQDREYVLACLGDIRRALVSLGDPVITLANNTTMPEISTTAIDQEVSRLKAMSFFTDIFGSGKDDPVHLIETIEPVLDPSAVRYTDENGNVSENIEPSTTVQNLIEFLNQGDATLKLFLWRRLREAYDSIDYPTKVVSCHFRALETAVQELGRPVRMDFPVNERRSSLLKWLKLADDILTSVMRRVVNNSEVSFECFDWAHLQMSMSSLARLSRILQSFAFYEDGVRVGQITPADVRPASTAKSLEQFKEKLRGLFVKIWMVQYALLREGIGQNKDLFDTPLDDRIHFLRSVHNALGLRSYCKYPKNLFVKLMRDELLTLETDDVYEDDLAQVLYDLYKFKFSPHLDVSFEHGCPYEPLDQEIALKLVDFTISQTKRMDIKDYLKSDLKTTVDALQRQIGLTGKSEVSTPLNKRILSRFLKTPINPLDLFRCVQGITGLSMIPVYSRSAELADKGWFTFLGSAALAKFRSLKKIGPTPTDDLDLAATLFRHDLEHGKDRWETWYQLAQVYDLRLEEDVAWSAEKLNNDREDLATIERRAIHAYSMAVATAVQTGDLKPSEKKQVSELYAEFGLRIYASTREPLSMGAFDVSPFMRHFSSDADQRMYEGKPFSAMKPFSAWYFASFLFHKATKENPMNWSNDPLKERYKTIEPSDILDSLTDAIDALPKKKDGRASEPILEPHFKLVSITHKLVRRGDLDPKEASEKLLATPWAKGLSPATDLESWKPFILGVLKQLQNADKSNWHHRIVLRAAHIIYDDSKDKEAAIAAKNDLTQHIFTKTMTVQVWRPENERAGRHFVYTTRYVYFFVQLLDQLDDRANLDMLVRRVRRKVNDYLNFPKLWEDTCITYIKLLRRIGNIPEGKEDAVFKGVSLDDFTLYSGRLDAWCQNPAKEEIPTIELLRDAVELKKLNGTVIKSGMFDDLVADIYAQLYEKTLPQFVEQVAGEENRERMKVDHLLMAGDSGDGAETPPATTSAQAPASRPRAKGVTRKEVQKKADAIAAKAPRPAPKPAKAVEDEAKQTQAERQTEEEQTDNGPAAEAALDENKEEKGKEDANADDKDENDGVEKEDENNEEEKEEENNEEEEREGEDNEEDEKEGEDNEEEKEDNPEEEDKEGENIEDKEASGPDPSIHDTTEEESGLSELETEAGSGDTLKPSSPIFQHLLRARMLSPKAGSELSTVTSGEGGDNDSIPAPSIHDTKMEIDGEAEAGDDGSDTEELPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D952</accession>
    <name>D4D952_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022239.1">
        <property type="nucleotide sequence ID" value="XM_003022193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D952"/>
    <dbReference type="GeneID" id="9576841"/>
    <dbReference type="KEGG" id="tve:TRV_03642"/>
    <dbReference type="HOGENOM" id="CLU_008442_1_0_1"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="761" mass="83558" checksum="5DB5EE6B727F1944" modified="2010-05-18" version="1">MPASKLECCCGRGDCAYLEHNSAALAELERDVETAARLGQALLDRHESYKIEAESTRDRMTAEMEKLQTSKKETEAENARIVEENRGLLDQLEKLNQLLIESDAQVRTLTTTLQSTQLEVRRLSSSTKRVEQLEEQLLQLENEQAKLEDTLILTQESESVAIQRWRKAECALGDLHDQVDRIEREARKERERHVELIGRLERRRMVERELDTAAGRIKGAAATASLSRNGTGTNVVSHFVRDILKDNASLQQCVTELKEMLHNSNEDVKYLREQLLLHQPLDPVPSEEHTYGNLVSLSEELDEDKLPDQMPQEIHVHHHFHNPISTPSRKEKSTPIHRRQRKRRPVLPPTLHENPSRAIPMSQAMHRPTNSASSVASAFSQASSSLPGAGSALSSIPSSPLSGYRSSSIFDRHDSGFESSRPTSPESVIFSPPRYNKQSHRPRLSDASFRSINENDELDKAESSLLSVEGLAGTRPDNDVNQPVECNGAENSTVEKGHNPQQELDGEGIGSSRCNDSSSGPGDEVTRDLNSSIHPLGDALEFNNSTPIQSPKISCQLHRSNSHESLLSVSGMDLHTTSKHPALALRGNPSFFPRPPKRVSNTSIMLPSPSPIISKTNAIVPKASLTGEQTSVSLLSSVVSSNTRGNLRAVSDSASQIHSDAASTISASSESTVPSKTGASARTIGIRKRMGSWVREKWSTNTVDEPGSTASSLTVGSLVPRPPGVNQNGPILGLRPPPPAPVSLHPENLNHDLLQESLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D957</accession>
    <name>D4D957_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022244.1">
        <property type="nucleotide sequence ID" value="XM_003022198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D957"/>
    <dbReference type="GeneID" id="9576846"/>
    <dbReference type="KEGG" id="tve:TRV_03647"/>
    <dbReference type="HOGENOM" id="CLU_045864_1_1_1"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="280" mass="32035" checksum="840563C1C0F4880A" modified="2010-05-18" version="1">MADTQFDSALDLLRRLSPRNTKENLHNITTLVPDLTEDLLASVDQPLEVRRCPRSKRDYLLCDYNRDGDSYRSPWSNEFDPPIEDGTVPSERVRKLEIETNKAFDIYRDLYYDGGVGSVYFWDLDDGFAGVVLLKKGITPGSKNSGAWDSIHVFEATDRGRTCHYKLTSTVILHLSTGSDTLGEMDLSGNMTRQIESDMAVNGDESHVANVGRLVEDMEFKMRNLLRMITQNLCFPVAYIMMLTTVLLEEVYFGKAKDVVSELRSEYIIRCLPWYCYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9F1</accession>
    <name>D4D9F1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022139.1">
        <property type="nucleotide sequence ID" value="XM_003022093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9F1"/>
    <dbReference type="GeneID" id="9579036"/>
    <dbReference type="KEGG" id="tve:TRV_03742"/>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="541" mass="60511" checksum="EBF434EDC7DF5025" modified="2010-05-18" version="1">MASRPNFLVIVADDLGFSDAGCFGGEIKTPHIDSIASNGGVRFTDFHAAAACSPTRSMLLSGTDNHIAGLGTMNENQTEFQRGKPGYEGYLNDRVVALSELLRDAGYQTLMSGKWHLGLDPDHTPHARGFDRSYSLLPGAANHYGWEPQLQNPDEKAPGLMSHMPSIYVEDDRRIDPSELGENFYSSVAFTDKMLEYLRGKDAEKPFFAYLPYSAPHWPLQAPRKDIDDYRGVYDEGPEALRQKRLRKLEELGLIPAGTAPHDVVVMGNRMMSRFWHDLTPEERRFSSRCMEVYAAMVQCMDTQIGRVLDQLRQSGDMENTLVIFMSDNGAEGALLEALPVVQNNIFEHIDQYYDNSIENLGAYNSFIWYGPHWASAATAPSRLYKMFTSEGGIRVPLILNYPPLTAGKAGIDHTFGTVMDIAPTLLELAGIKHPAPSYRSRPVYPMRGSSWLPWELFGRQAVRQGDWKALHIPKPVGPGKWQLYNLSEDPGETKDLGELFPDKLAALIAEWKKYEKDVGVVGAMQYGVLGVDDQDVIQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9G2</accession>
    <name>D4D9G2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9G2"/>
    <dbReference type="KEGG" id="tve:TRV_03753"/>
    <dbReference type="HOGENOM" id="CLU_3430007_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="19" mass="2442" checksum="C8A635E46F5F4DC6" modified="2010-05-18" version="1">MMKRREEEGKEEEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M8</accession>
    <name>D4D9M8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_003022034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M8"/>
    <dbReference type="GeneID" id="9578964"/>
    <dbReference type="KEGG" id="tve:TRV_03821"/>
    <dbReference type="HOGENOM" id="CLU_014084_0_0_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053129">
        <property type="entry name" value="Integrator_complex_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48194">
        <property type="entry name" value="FINGER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48194:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="318"/>
            <end position="482"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="683"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
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            <begin position="44"/>
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            <begin position="204"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="590"/>
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        <location>
            <begin position="651"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="759" mass="83318" checksum="9480D4535C2AD265" modified="2010-05-18" version="1">MPIISQTPNMAPTDEEEAAAECDEPPGCRARVSTVRSHSHEHAPTSSNKTTVSISNSRPKVTKESLLTRALLSSPELSPTDRAASGITWRSVPAFSINPSHSGPSTAELTSDGELTTPPRSTTPSPPPPTQFTRPPWVAAEPPSKPVSPVDEHELKLEANLGRKRCITFACANKIDPVDHTQSDPVAADPPKRKSTIKFACPARPRDTDVDIKNQKHSPSKPSAGIRGSRSPAPMSLQSRYQARSLEVSQIPGIKPTEPAPATGSLKVTGLGKFELSDATRFQEFGSSLEDEDWLNESSDYKHKMTVDDCMRKENVIRKLGEEVEAEAQEEAEEAENDEDDDENDDDDDENNDDDDEEEDDDEDDDEEDEDEDDEDDGNQDLSDDGNETDNEAGFGSSDDDDGESDYAFWTPTTTAATSHSDITIMPPPMKWKESHGSIESLASPGPLDTVPPFEPKRAAAVKEKKSKPTAPSLPDSTDFVCGTLDEDRSIEVAYISRMEERRRQKHIPIPQDIDPSFPTSDIEDEDDEDADDDVSANPTAARKQKADDDDAVEPPRGRRSSRTTIEKSSKAAAHSPRRLFGHSPRRLRSPPPPGRLRSPPPSRRTSLINPPNLGAGPTAKKIAVALAQRPNRTRTSSLPRTPNPFFARGYSSNIYKRTSRSPSPGQKASTKTKSSPTHTRGPIDIVAGLEKKRQKRKEKFWRQHCRRAAKDQIHSREKMVPGRGAERMKELGIEVAERFRAYGVGVNGGNGPKLVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9U9</accession>
    <name>D4D9U9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytokinesis protein SepA/Bni1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000199">
        <property type="protein sequence ID" value="EFE41380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021998.1">
        <property type="nucleotide sequence ID" value="XM_003021952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578882"/>
    <dbReference type="KEGG" id="tve:TRV_03892"/>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytokinesis sepA protein"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Formin, FH2 domain"/>
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    </dbReference>
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        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DAD_dom"/>
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        <property type="entry name" value="FH2_Formin"/>
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    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
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        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
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    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
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    </dbReference>
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        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="235"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
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            <begin position="1487"/>
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    </feature>
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            <begin position="1"/>
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        <location>
            <begin position="1457"/>
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    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1341"/>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
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    </feature>
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        <location>
            <begin position="166"/>
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        <location>
            <begin position="198"/>
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            <begin position="1204"/>
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        <location>
            <begin position="1479"/>
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            <begin position="1514"/>
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        <location>
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        <location>
            <begin position="1647"/>
            <end position="1663"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1675"/>
            <end position="1685"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1685" mass="187867" checksum="4DAA936B47DE3AC9" modified="2010-05-18" version="1">MTSDKPSKSFFGRKLHKERQPDLRAETPESFGAASSGSGSRSSRYSKRESGLSVDLTGDTEYLSGVIGSIPYDSVPVRKEPTPSKMGKPNDYHQYPQFQGHQPANGAMHLSGPRPPPGSSGTTASYYSQSDKGVKYQAWNGHNAYPTTESSNPRTSMDQNSIYSAISSAPRGSTHTISTDNASRYNYPTHSQDPRNQPSSSSGSRPSTSSRSDWLPPQLPIVFGTLPISADGTIQRPKDDAVVDQMFYELMIKRGWQNLPEQAKRQMLAYPTSKKWTLVHQDRLTQWQGEQKRRQQNRQTGSGDGGKGLLGRADEEGSPEWYVKKVMDDSITAKELGSLSVSLRTQPIRRKASGPVPVTNSGGDKDLDREYDIAKCLKALMNNKYGADDALAHQQIIVALASSLISPRLTTRKLVSEILTFLCDWAHGQGHQKVLQAMDQVKNMQGETGRFDAWMRVVEVSIDGRGKMGSLVGASEEFRSGGIGMENLLMEYALATMFLINMFVDASEDDLQLRCHIRAQFTACGIKRLLAKMEGFQYEAIDRQVERYKENEGIDYEDLLQRESSSMKDSIEGEVSDMNDLIQITNAIISRLRGDRSQDFFISAMQHMLLIRENSGEDSHRMFQLVDAMLSYVAMDRRLPDMDLKQSLNFTVQSLLDKLHTDAEARRAFDESLEARQIAEAAIAERDEMKARIEMGADGLVKKLQKQIEEQEAVISLQTRQNESLKSELAEVQRIRGQELQRNELETRELYLMLRDAQDVAASKSKMTGTGGDMGTMDPTQMNGILDREKLMSRLERQLDRAKTQFKLEGKVWPQNGPSDRLRELRELMEGDFSHDPEIDEETKRNFTHSTFGTVSRKRSQALKANASNDEDSRDGELDDLEEEGEEAVFEKGRLVEIRRPKLDPERATALLGEIASKAGEREKELEKEKEKEKEEQEKTSTPPAEAPENKETKDAGSDNLAGFNGPPPPPPPPLPGFGGGAPPPPPPPMPGFAGGAPPPPPPPMPGFGNGAPPPPPPMPGVGMPPPPPPMPGGWKKTYLPAGQVSTVPTVSLPFIRPKKKLKALHWDKVDTPQVTVWAAHAPTHEAKEQKYTDLAKKGVLDEVERLFMAKETKVLGRSGKKTDKKQIISSELVRQFEIAFAKFSQISADELVRKIIHCDTEILNNTVVMEFLQKDELCNIPENTSKLMAPYSKDWTGPGAATTEREQDPSELTRQDQIYLQTAFELNHYWKSRMRALNLTLSFEQEYDHISSSLREIGQVCESLRDSVSLMNVLGLILDIGNFMNDSNKQAAGFKLSSLARLGMVKDDKNESTFADLVERIVRNQYPEWEGFTDDIDGVIRVQKANVDQLQLDAKKYIDNIKNVQMSLDSGNLSDPKKFHPQDRVNLIVQRCMKDARRKAEQLQLYLDETSQTYDDIMVFYGEDHTDENSRREFFPKLATFLQEWRKSKEKNISWEENRRRTEASLARKRAKPGLTNGIDSGTPTSPTSNGAMDSLLEKLRAAAPQARDQRDRRRRARLKERHQVRLASGQHVPGITVNDGQDSESTTTAEPAATPKDDTPQNSQSKGEDIADRAASMLQGLRSDNDSEGSRSRRRNSAEEARRSRRMRRRAPATTSASTNKESNDGSSLLSAHPEPEGGSRRDSSGSTASAVLGETTNEPETSPRPLPATPGGTDSNPITISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y3</accession>
    <name>D4D9Y3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021978.1">
        <property type="nucleotide sequence ID" value="XM_003021932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y3"/>
    <dbReference type="GeneID" id="9578851"/>
    <dbReference type="KEGG" id="tve:TRV_03926"/>
    <dbReference type="HOGENOM" id="CLU_966344_0_0_1"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="270" mass="28817" checksum="B1C718AF3E6BA523" modified="2010-05-18" version="1">MYIQVLICGHRFLEVLLYALDADRPVFPHPGSGPANTSHQALVLVYGTCVHIYNSWRIKKIGAAEKLKKAEEEATIGTKDLNLIPFGSRALESGIEIEGIWVSRTNTPLPSPIPAATPETTRPGTPSNIDLGAAALPSPRGGGSALGRRQDESLLTTNGLKAAVARGLDKNSSSDTSSTRISYESSLSSPPNGAEGEGTEQTEIPTLFDSFDAAMHAARARSHLTASMMITNDRFDSSGVFLAYESPTILLRKTSPFTFSLPAALHQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Z4</accession>
    <name>D4D9Z4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021951.1">
        <property type="nucleotide sequence ID" value="XM_003021905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Z4"/>
    <dbReference type="GeneID" id="9578835"/>
    <dbReference type="KEGG" id="tve:TRV_03938"/>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="41832" checksum="4AE0DC09C81DBAC9" modified="2010-05-18" version="1">MIAIGLEGSANKLGVGVILHPDDGSTPQVLSNVRHTYVSPPGEGFLPKDTARHHRQWIVSLVKKALIDAKIGVADVDCICYTKGPGMGAPLQCVALAARMLSLLWGKELVGVNHCVGHIEMGRYITGATNPIVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKKLVEIPYAVKGMDCSFSGILATVDALAASYGLGGEEQAKKDAAEVARHAKVETIDSLKDDDGVVTRADLCFSLQETVFAMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVYATDERFCIDNGIMIAQAGLLAYKTGFHTPLEESTCLLFIAAFIYNSRIILAEAREWATLFQNKANLVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS8</accession>
    <name>D4DAS8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021646.1">
        <property type="nucleotide sequence ID" value="XM_003021600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS8"/>
    <dbReference type="GeneID" id="9578607"/>
    <dbReference type="KEGG" id="tve:TRV_04226"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000922">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="46244" checksum="86F9B0BC27C03827" modified="2010-05-18" version="1">MANIMRWATKALRKPPLVPIIFPTGGFETVPPSVVLEEERFKQFKQGQYYPANIGDVLTSRYQVIGKLGFGTTSTVWLARDLEYVTLKIYTLGEDNQEEFQIYKKLNQGSSRHPGHAHIRKALDIFTIFSSCGSHSCLVQKPMWESFRDLLYRNPNHRFTEDLLKSGLMQIFLALDYLHTECKLVHTDIKSDNILQEIEDKSILESFTQAELKSPSPRKIVNGLPIYTSRRFDLPKVFGRAVLSDFGSAVRGDEKRNHDAQPNVYRCPEVMLKTDWSYPVDIWNVGAMVWDLLEGRHLFYGNDPDGKGYSTRAHLAEVMGFLGPPPLDMLQRGKRSHEFFTSDGKWKQDLEIPTGVSLELSEEFLDGKSKEMFIAFMRGMLQWRPEDRKTAKELLQDPWLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB03</accession>
    <name>D4DB03_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04302</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021593.1">
        <property type="nucleotide sequence ID" value="XM_003021547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578554"/>
    <dbReference type="KEGG" id="tve:TRV_04302"/>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="282"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1284"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1295"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1318"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1335" mass="145168" checksum="F0B005422355632F" modified="2010-05-18" version="1">MRSIDFPKPHANRHVETSKISRLLTMYDEFPNTRQNMMADIATAPISVYAVRPRISGSQDFKYNCALISRGYPSQDAFAAGDIINIAFPFVVEGYLLTSTTLSTSTFPMANNNRLLAPAITIDTHYDNATSSSTDPISPLSPTAAQELSPDRPSSSNDANSFLFPRSPNSFDGETLRSRANSVNSNVDTLRSRSGSTVKPLGRSDGADYDDVPLSEALKADERNKRDFEVENNPFAFSPGQLNKLLNPKSLAAFKALGGLKGLEKGLRTDLTAGLSLDETHLEGSISFEEAVQSSSTKHQDSTASTPQPSVSSGGAQFTDRIRVFDRNKLPERKSDSFLVLLWRAYNDKIIILLTVAAVVSLSLGLYETFSGGSNVDWVEGVAICVAILIVTIVTAVNDWQKERQFVKLNKKKNDREVKAIRSGKSIMISIFDITVGDILHLEPGDAIPADGIFLSGHGVRCDESSATGESDQMKKTDGHEVWDRINNGTATKKLDPFIISGSKVLEGVGTYLVTSVGPNSSYGKIMLSLQTSNDPTPLQVKLGNLADWIGGLGMAAAGTLFFALLFRFLAQLPDNHHSPAMKGKEFLDILIVAVTVIVVAIPEGLPLAVTLALAFATSRMVKENNLVRILRACETMGNATVICSDKTGTLTQNKMTVVTGTFGMRDTFDRTPEAEGEGPSAVTQMFNEASTAARDLVMKSIALNSTAFEGEENGEKTFIGSKTEVAMLHLAQRYLGLSLTEERASAEIVQLIPFDSARKCMGVVIRQSDGTFRLLVKGAAEIMLYQSSRVISGLSTSQLESNVLSSKAKSEILDIINSYAKRSLRSIGMVYKDFECWPPQGAKTMEEDKSCAEFNDVFNNMTWVGVVGIQDPLRDEVPGAIQKCNKAGVSVKMVTGDNLTTAVAIATECGIKTPDGVAMEGPKFRQLSDEEMDRVLPNLQVLARSSPEDKRILVTRLKHLGETVAVTGDGTNDGPALKAADVGFSMGIAGTEVAKEASSIILLDDNFKSIVTAISWGRAVNDAVAKFLQFQITVNITAVVLTFVSSLANSKGESVLNAVQLLWVNLIMDTFAALALATDAPTEKILDRKPSPKSAPLFTTTMWKMIIGQAIYQLVVTLVLYFAGAKIFGYDLENDPSGLLAGQMDTIVFNTFVWMQIFNEFNNRRLDNKFNIFEGMFKNYFFLGINAIMIGGQIMIIFVGGAAIGVKALTGVQWAICIGASLPCLLWAVIVRCLPDRHFEVVMNIVITSFNFFWKPVAKAFRVIFTPITKAFRRVFVHKKGEAQTEDQQAEELNETRPRDEETGDIEKQADTASPFVAPPTIAPPPITLTAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB08</accession>
    <name>D4DB08_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021565.1">
        <property type="nucleotide sequence ID" value="XM_003021519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB08"/>
    <dbReference type="GeneID" id="9578525"/>
    <dbReference type="KEGG" id="tve:TRV_04307"/>
    <dbReference type="HOGENOM" id="CLU_045564_1_0_1"/>
    <dbReference type="OrthoDB" id="5325862at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="30735" checksum="AAE12A90581E04C4" modified="2010-05-18" version="1">MTAYAMDSRKSAELQTEVNQLSEKEVEILKSSAASDTDVEGEAPPTYSESTTIALPRSINQAFTPGRSLYINSRGIGMIRFPTPSSELEIAIHNQDGSLAYVSTRDKLCSGDAVLSSPKLGNLLSTTYFFGPGRHPVLRQLYPTPFNGDSPDTNKDITVAGKFISRSADFEMPDGSKFEWRYVRLGYDGGGRSKLLVLEKIEGEGDGSRKRVAQLLRTKETIPQGSSKHRAGCGGELVLDQDAHLNIDEAVIVGTCLLMLKREVDRRRAIQMMVMTGVVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB62</accession>
    <name>D4DB62_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021514.1">
        <property type="nucleotide sequence ID" value="XM_003021468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB62"/>
    <dbReference type="GeneID" id="9578462"/>
    <dbReference type="KEGG" id="tve:TRV_04361"/>
    <dbReference type="HOGENOM" id="CLU_010392_1_2_1"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66714" checksum="7265E5FC7C6D2579" modified="2010-05-18" version="1">MQTYGSILPESRRYNPPEILKGGWDVIKSNPLFAVDAYNFGVLIYEAFNGSFHGPEQAGQTSNIPPSMRPSYKKLLNSNPKLRLSVAHFLEQGKRSGGFFQTPLIRLSQDIESLGLKSEEEREQFINTNLKNSELDELSDDYPEEFFKMKVLPELLKSVEFGGGGPKVLSTILKVGTKLSDDEYSQKLTPVIVRLFANPDRAIRVCLLDNLPLMIDRLPQRTVNDKIFPQMVTGFTDLAPVVREQTVKAVLAIIGKLSDRTINGELVRYLAKTANDEQPGIRTNTTICLGKIAKNLSASSRPKILVAAFSRSLRDPFVHARNAGLLALAATFDLFSEEDCAVKVLPVISPALIDKEKLVRDQANKCLDIYLQRIRKFTSTMADTALPPQERADSSVAAARLPSPANTAASWAGWAISSFASKAGETKGVIEPIQPALPKPNGKAVDNSLPPSRARSATPTLAQNVAQFSQPTIGGVSQATPDLLEDEDSNAFDDWGAMDEAIDDEPDRQDQEPIVFEKAASPNPAISPRPHNFADDGEPDFAGWLASQSKSKSKNPLPKGLKKSSTPGGSGTAQAKRTEVKPKTPIKPAKTIDTKPKDEPLDDDGWGDAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC1</accession>
    <name>D4DBC1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000221">
        <property type="protein sequence ID" value="EFE40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021479.1">
        <property type="nucleotide sequence ID" value="XM_003021433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC1"/>
    <dbReference type="GeneID" id="9578440"/>
    <dbReference type="KEGG" id="tve:TRV_04420"/>
    <dbReference type="HOGENOM" id="CLU_2724034_0_0_1"/>
    <dbReference type="OrthoDB" id="4173724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="72" mass="7942" checksum="0EA51E363DA567DE" modified="2010-05-18" version="1">MLPRSDPSDMASPPRKRRKLDAAGSHISCFPEIYGQELKMRTAEDKQQPGDEPDNSPNEKNEVEAGNESADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS8</accession>
    <name>D4DBS8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000230">
        <property type="protein sequence ID" value="EFE40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021317.1">
        <property type="nucleotide sequence ID" value="XM_003021271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS8"/>
    <dbReference type="GeneID" id="9578161"/>
    <dbReference type="KEGG" id="tve:TRV_04579"/>
    <dbReference type="HOGENOM" id="CLU_018012_2_1_1"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64100" checksum="2FFADCD080101AC8" modified="2010-05-18" version="1">MLSRLGWTEFALWILLPLYLLYIMQRWFALRVVVKIPPLGWSKVPYIGHSLSFLRGGAELHSMFEPYRKTTTPVHFNICGTDLFLINSPEIVRKIANKPHIFMEGALRGDFALKVLDLPKSAAQVLGNDNSGSALRPLPGSTLPPDRRIVRMQHETTFNLLTSPSGIHMFVLQFTNFMEKLILSNGIGEQWVELPDLFHFIQNLTSTAMMNALCGPRLVGMNPGFVDEFWTFDLNIHYLNLGIAPLFRAESVKARDTCIKALIEWKKNAIQDSADKEYPESLLWDEIWGFKIMRDRDDMYSRFPEYCNDQARASADLGILWACNDNLIPVGFWLVQRILNSPNLRERFMKEFDNARLPSQPGDILPRFNTHILAKTPFLQSTYHEVLRTQVTSFTARTVRQDCQIGEYMFPKGSVTLSSSWGVHNNPDLWESRPGAQEHPVEEFWPERFLVCPYDRAAREGKSFPESGKEPEFSLKGLDGTFFPFGMGHNACPGRHFATHAILNIAATILSVFDFEPIDTWAGGGMDYTTFGYTPARPLRKIPFKIRRKILPVAVEDRCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC07</accession>
    <name>D4DC07_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhomboid family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021227.1">
        <property type="nucleotide sequence ID" value="XM_003021181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC07"/>
    <dbReference type="GeneID" id="9578072"/>
    <dbReference type="KEGG" id="tve:TRV_04659"/>
    <dbReference type="HOGENOM" id="CLU_057574_0_0_1"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40388" checksum="B75329A3668844DC" modified="2010-05-18" version="1">MLFILDIIMSNIKYQISISNINIKTSTSSSNVNFKLSLIVVTSRWSVRINHFGPSGRGIEKKQRGKPEEAKERIRMLSSGFTNAPVTKLALVYIIAASILVSIADAKYLFYIQVNPHIWQYHQLWRFLIWPLTGHRTAMGIEESFILSTLPFTTFLPPLILTITVRPLSLNTLNHLPAGPTAILFAILAQYHATIPTTYKYRLLTGSSGNGPAITFSDKSTIYFLAFQLALSQLPHTILPAFIGWVIGYAWRAELLPSKISSWRIPGWIYGGSPERQRRRGIPRNRGDGDASSSGTGSRDPERLEGLRRRLEGESRAAFVAVASTDTDGGRRSTGSAGGGAGGVQEGEQRRPLAGQILDRFRGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI6</accession>
    <name>D4DCI6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021065.1">
        <property type="nucleotide sequence ID" value="XM_003021019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI6"/>
    <dbReference type="GeneID" id="9576712"/>
    <dbReference type="KEGG" id="tve:TRV_04841"/>
    <dbReference type="HOGENOM" id="CLU_065163_2_0_1"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="222" mass="25314" checksum="92ED287C44711387" modified="2010-05-18" version="1">MLQPTNFLFISNVQSRPITVEKPTPYVFDLGNLMALDANPIDLPQSAKSSPLILNQTLKATARDGAQCLVNQLLTTCPITSSMQDGVLLTLPRPTTMVPRFKPLPTPKPPTKWELFARKKGIGKYNTKLGSGLADTERKKNLVYDEEKGEWVPKWGYKGKNKGTEDDWLVEVDESKWKKEEQMNNEGKSIRNEGRKERMERARRNERKMRANERKARTGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCQ7</accession>
    <name>D4DCQ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021047.1">
        <property type="nucleotide sequence ID" value="XM_003021001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCQ7"/>
    <dbReference type="GeneID" id="9576694"/>
    <dbReference type="KEGG" id="tve:TRV_04912"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="496" mass="55182" checksum="1E8FF687DE2FA9CD" modified="2010-05-18" version="1">MGVKAEADVSPDLSIEQDSELPQLKNTTERKLMAKIDLYILPMLSILYLLAFLDRVNIGNAVIFGLKKDLGITSGTQYNTALTIFFIPYVLFEIPSNLLLKKFKPHVWLSLCMFAFGLITCLQGITTNYAGILATRFFLGLAETGMFPGCFYLMGMWYKRSEAQKRFSFFFSSTTLAGAFGGLLASGIGKMGGLRGYNGWRWLFILEGVFTCVVAVIWFFLIPDFPEDVKWLTEEEREFIKAKLAKDVGKAGVDAKVTFKDVISIVSDRESYRSSYPSSNCFYTNLGFTAKVLIGGFMYLGMIVPAYTKLFAAIETQLYSIPPWAVAFVFAMLMAYVSDRIAHRVSFATLPIAFAIAGFSMLLTVHGKENRHIQYGALFLITCGTYSAMPIIICWYAMNLSGHKRRAIGTGWQIGFGNIGGIIATYSFLEKDAPQFKPGHSISIGFLCLAVVSSVLYLFLILSRNKKKDAQGAPTQALDQEDGDLGDLSPNYRYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCW7</accession>
    <name>D4DCW7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">xanthine dehydrogenase</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_04973</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020897.1">
        <property type="nucleotide sequence ID" value="XM_003020851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCW7"/>
    <dbReference type="GeneID" id="9577749"/>
    <dbReference type="KEGG" id="tve:TRV_04973"/>
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    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <position position="65"/>
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            <label>1</label>
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        <location>
            <position position="751"/>
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            <name>Mo-molybdopterin</name>
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        </ligand>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE40279.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1179" mass="128548" checksum="180FDA97FA54FCB6" modified="2010-05-18" version="1">MAPAIVEEPQPPASKASLAAVTEKYDDTLRFYLNGTKVTLDSVDPEATLLEYLRGIGLTGTKLGCAEGGCGACTVVVSYRNPTTKKIYHASVNACLAPLVSVDGKHVITVEGIGSSKNPHPVQQRIAVGNGSQCGFCTPGIVMSLYALLRNDPTPSELAIEEAFDGNLCRCTGYRSILDSAQSFSTPSCAKARANGGSGCCKENGGSCNGGAKNGDCDGITPKAITQSFNTPEFIPYNPETELIFPPQLHRHELKPLSFGNKRKRWYRPVTLHQLLEIKDAYPEAKVIGGSSETQIEIKFKARQYTHSVYVGDIPELKQYTFTDDYLDLGANVSLTDLEEISTASPISDLNPVFVATGTILFAKSLKEEVQIPMDQFFKGYRTTALPANAVVAKLRIPISRVNGEYLRAYKQAKRKDDDIAIVNAALRVSLSDSNVVMSANLVYGGMAPTTIPAKKAEEFIVGKNWTDPATVEGVMDALGQDFDLPSSVPGGMPTYRKTLAFGFFYRFYHDVLSSIQGVQVHCEENAVPEIERGLSSGVKDHEATAAYTQKIVGKATPTVSALLQTTGEAQYTDDIPVQKNELFGCLVLSTKARAKILSIDFTPALDIPGVVDYVSAKDLLNPESNWWGAPVSDEVYFAVNEVITDGQPLGMIVATSARLAEAGSRAVKVEYEVLPAILTIEQAIERNSFFKHITPAIKKGDVEAAFASSDYVYSGTTRIGGQEHFYLETHACVVVPKPEDDEIEVFSSTQNPAEVQAFVAKVTGVAENKVVCRVKRLGGGFGGKESRSVQIASICALAAKKTKKPVRCMLNRDEDIATTGQRHPFLCHWKVGVNKDGKLQALDADVYANGGHSQDLSLGVVQRALSHIDGVYKIPNVHVRGYLCRTNTVSNTAFRGFGGPQGMFFAESFVSEIADHLKIPVEKLREINMYKDHEETHFNQALTDWHVPLMYKQVLEESNYYARQKAVEEYNRTHKWSKRGIAIIPTKFGLSFTALFLNQAGALVHIYRDGSILLAHGGTEMGQGLHTKMVMIAAEALKVPQSSVFISETATNTVANTSPTAASASSDLNGYAIFNACEQLNQRLRPYREANPNATMKELATAAYFDRVNLSAQGFYKTPEIGYKWGENTGKMLYYFTQGVTAAEVEIDTLTGDWTPLRADIKMDVGQSINPSIDYGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDE1</accession>
    <name>D4DDE1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oleate delta-12 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000263">
        <property type="protein sequence ID" value="EFE40126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020744.1">
        <property type="nucleotide sequence ID" value="XM_003020698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDE1"/>
    <dbReference type="GeneID" id="9577449"/>
    <dbReference type="KEGG" id="tve:TRV_05152"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="157"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="500" mass="56335" checksum="0972954919C87766" modified="2010-05-18" version="1">MSCSGTRRLASFLSALDRELKPPRFADKMASTALPAGAATRRQMAASSSASSTTASPLDTPQHMSASDTSLSSESEDQQDSGVGKLVDTYGNEFQLPDFTIQQIREAIPAHCYKRDGFRGMQYVLRDIACLATTFYIFHNYVTPETVPSTPARFVLWGLYTFIQGLFGTGTWVLAHECGHQSFSTSKVFNDTVGWVLHSSLLVPYFSWKISHGKHHKATGNMQRDMVFVPKTREAYASRIGRLVHELDELTEETPIHSIIDMVLQQLFGWPMYLFTNVTGHNFHERQSEGRGKGKSNGFFGGVNHFNPNSPLYESKDAKLILLSDLGLLIVGSILYTLGSKFGWFNMFVWYFVPYLWVNHWLVAITFLQHTDPTLPHYQPESWNFTRGAAATIDREFGFIGRQLLHGIIETHVLHHYVSTIPFYNADEATEAIKKVMGRHYRADTKDGSLGFLRAMWTSFRTCQWVEPCETAKGEGKGVLFFRNRNNIGLKPASLKPVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDQ0</accession>
    <name>D4DDQ0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000268">
        <property type="protein sequence ID" value="EFE40021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020639.1">
        <property type="nucleotide sequence ID" value="XM_003020593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDQ0"/>
    <dbReference type="GeneID" id="9577340"/>
    <dbReference type="KEGG" id="tve:TRV_05261"/>
    <dbReference type="HOGENOM" id="CLU_1518935_0_0_1"/>
    <dbReference type="OrthoDB" id="4170767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="199" mass="21407" checksum="B2BDCBDA8B53F5A2" modified="2010-05-18" version="1">MSRHCCKVQRNCVAESEGMSAAGSSPASHIEDLCTVTSQPFNDDNSVISNDTQLLYPSTEDTILFPAASHNDKAIIPDYTLPHLTLFDCVHEADVTMAGFTNNTDIGSYLQDYTGVEDGFPFNPCSSSTIDHLSLSSGLGTSSLVSAGMSECQSNDTGLSLPNCSVMTVRLTNPAPEAVHEFIRILMAHQQQVTIDIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDT0</accession>
    <name>D4DDT0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020615.1">
        <property type="nucleotide sequence ID" value="XM_003020569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDT0"/>
    <dbReference type="GeneID" id="9577314"/>
    <dbReference type="KEGG" id="tve:TRV_05292"/>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="282"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="797" mass="86864" checksum="99E2229B76F3ED3D" modified="2010-05-18" version="1">MALDTNAIDSSTVPPTRHRSILSKLTSRFGNRNRNISEFYVQPDDPWKSYHPGEIVKGAVVLTVVKPVRITHLVVCLHGYAKVFKNTVGPGDHAEESGYLGPGRGRRDGEYLGNGFTSLFEDEVVLCGDGRLKEGIYKFRFELCFPPYSLPSSINFERGTISYMITSTLTRPTTITPSMSCDKRLILIERIDIAPLPAPKARVITLEPISARSKSKPRKKSTSGERGFNGAAGPASLEPSSSQTSEQKPPLSPVPSEQSTSSYLSNSTQSFQVISESNTARDSDTITATTKLLRGGGLPGDVLPLRIMINHTKPIRSPHGIIVTLYRQGRIDMYPAIPIGTPAKGKRPVYEDYYPKSRTGLGGLSFGATRTCSVFRKDMSQIFCPLIVDPNTMTADIKTSIRIPEDCFPTITRVPGAMISFRYYVEVVMDIRGKLAGQDRFLPRLNIMNSSSNSYNYCAAPRGFNTVETSRGGTSTTSSCTGNILDTDQVRRDKSVIVCVFEVVVGSKDSGRGQQQQTSSDGSVRQDYPASNIDQHTQPTTPETVREQQQQSQAPQIHSADRSRGNRSLDNGYSAGSEDREPWHARPPDQYVIDPPLAQLEEDIDEKTRLRRAEAMLLPSAPPASDEAGPSNSTLALASAPALSEHRDLSYFETPTPTYSASAYMHSHPPSAPSPDTITPYSAHESSPALQHPGAYLLPESAAESSSHPNYHQPHSTSLPSDDKQELEKQRLLNERSAPPGSDAPESATGGPSQATAPASENGDIRHQPLPSAPVLTEDDIIGQPIATGESLPRYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE04</accession>
    <name>D4DE04_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Actin-like protein ARP4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020539.1">
        <property type="nucleotide sequence ID" value="XM_003020493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE04"/>
    <dbReference type="GeneID" id="9577238"/>
    <dbReference type="KEGG" id="tve:TRV_05368"/>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000063">
        <property type="entry name" value="Chromatin remodeling and histone acetyltransferase complexes subunit putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000224">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="471" mass="51214" checksum="9DBCA74F3613B737" modified="2010-05-18" version="1">MNSSAPPAAAEYGGDELSAIILDPGYASTRAGFAGEDTPKSVIPTHYGKYSTDAQEKYVYGDNIFVSPRPGISVHNPINRDGIVEDWEMAEKLWEYSFTSRLTSRKPGNPMNNGLNDPNPEDLPADMEGVEAEEKPLADSPLLMTEPGWNPTKAREKTIEIAMENWGTPAFYLSRNGPLASFAAGKATALVVDVGASNISVTPVHDGLVLKRGVQHSQLAGDFVSSQIRALLKSSTPPVNLTPHYLISSKAAVDAGQPAQAVYKDLPENKLPGPSYRRLIEDRTLSEFKECVVQVWPGPGALSAQGPNGTSNEELAKAIPMRPFEFPDGFNQLFGPERYRVAESLFDAKAALPDPDSEFPSPAANQTIPELIRNALNQVDVDIRPTLLANVVVTGAGSLLYGFTDRLNYELTNMYPSPRVRISAPGNTAERKFGSWIGGSIVASLGTFHQMWISKKEYDEHGPNIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE81</accession>
    <name>D4DE81_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020481.1">
        <property type="nucleotide sequence ID" value="XM_003020435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE81"/>
    <dbReference type="GeneID" id="9584220"/>
    <dbReference type="KEGG" id="tve:TRV_05448"/>
    <dbReference type="HOGENOM" id="CLU_1045758_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="29255" checksum="B86FF17B49819E07" modified="2010-05-18" version="1">MLTRMRIGQRYPILRRDVGSRTESLNGITVRPLSSVNVNTFDSNNWVDLLTGLTTGKKLKKRQEDQLRQTTSSPEHSPDESSSVRDEPYAAESESIEQHTARSLKPVLRPRLSSSSPPTNFQLTQESPPPLYSQSYESVSSISSAPMVTYSPYSTYSDGSISASYSCAPLPGVIPDIYGGQGQRLGFDGPESSISSPYFVSPRPERYCGIDVDYLTSSDLAVTSTATIAATMSPYMKMSDPMYHYDYSDLYPISTAPGSSSTSQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEN4</accession>
    <name>D4DEN4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000303">
        <property type="protein sequence ID" value="EFE39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020305.1">
        <property type="nucleotide sequence ID" value="XM_003020259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEN4"/>
    <dbReference type="GeneID" id="9584046"/>
    <dbReference type="KEGG" id="tve:TRV_05603"/>
    <dbReference type="HOGENOM" id="CLU_006762_2_1_1"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000163">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000282">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125021" checksum="60DE80EBEAC66AC2" modified="2010-05-18" version="1">MASHPQPSPPMHPHPSHHPALANHPQVNGHPSMAQQQAQQQQAQAQAQQAAQQQAAQQQAQQAQQQQQPPPGPQQGPQPQPGPPGPPQQAPGQPQKGMPPTISQKIAQLNEGVWLQIGTLSELMNDPDGAMYAFEQAIRHNQWSIPAMSAISCLLRSREQFQKAIEYLQAILKLDPQSGESWGSLGHCYLMLDNLQEAYTAYQQALYHLRDPKEPKLWYGIGILYDRYGSLDHAEEAFSQVMRMQPDFEKANEIYFRLGIIYKQQQKFGQSLDCFRYIVNDPPRPLTEEDIWFQIGHVHEQQKDFEAAKAAYRRVLEREPNHAKVLQQLGWLYHQQNNNYSSQEQAIEYLEKSVSADNSDAQSWYLLGRCYMSQAKYPKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQTSDALDAYGRAADLDPTNVHIKARLQLLQSGQAGGANAGNAPAPQDVHPQAYQQNVGAPPGPQWGAPAPGPGGLPPQGPAPPARIAEWGRPSGEPQNASNAHGPGSQFEQRDNVRGPPPSQPRVQASPRQEQFHEPHPPYRPPHHSISSSRKGGQSSPSPKFPLFNTHTYTGTQVLPQLAPPQQQQQQQQQQPQQQHEGPNNGPAPGPPPFPQPRQGLGPGPGHGPGGPGPNSQGPNGVGPSQYGRPFTPPTEIRPIREERPASANGTGPGNGANNAGGPGPAFAPPHQPPYHHVPGPGGPGQQGVQQNGGIASGAPAPASAIAAAEAAARERDERPASSMKRVREWEPEPGPGAGPVKKIANEETRSRLDGRHDTRMEDQPGPGQVPVQGQGPPPPPPGPPQGPSRRGSPGPAGPVSGMGGLNVRLASPRDLRRRSSSEARREDRDHARRAHEPYHPSDAAHHPPTLPPIQHMGGGPKSEPQTPGQASTGPSGGPQSLPSLSAGLPKDERDRDREREREREREREQRDRDRDREREREREQRERDREREREREREQREREREREREQRERDRDHDARDQRDRKDHSALPPVSVSSQGPLEPPARKMDVDEDYDDEGDDDTGSKKPSAMVGKGGSPGSVNGSGSVTGRDRERERDRDGQGSQRDRDRDRERERDRGDRDSQTKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEZ1</accession>
    <name>D4DEZ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000317">
        <property type="protein sequence ID" value="EFE39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020193.1">
        <property type="nucleotide sequence ID" value="XM_003020147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEZ1"/>
    <dbReference type="GeneID" id="9583970"/>
    <dbReference type="KEGG" id="tve:TRV_05732"/>
    <dbReference type="HOGENOM" id="CLU_1664998_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055822" evidence="2">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="159" mass="17987" checksum="D35E8F15C081F9CC" modified="2010-05-18" version="1" fragment="single">LSILIALSMGWFGCQHLSQTCLLQAQVGSYEVLGRENASIILRYGFNLHGSMCKGGDARRYPAMIVITTAYLSHILPVNLLAQILGNQESKRKRLGCEERVPLISPRALCWLRVALLHFQLRRLPTLTATELTFIHHINFCFSTLFGLYYYIICVINMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEZ2</accession>
    <name>D4DEZ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hsp88-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000317">
        <property type="protein sequence ID" value="EFE39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020194.1">
        <property type="nucleotide sequence ID" value="XM_003020148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEZ2"/>
    <dbReference type="GeneID" id="9583971"/>
    <dbReference type="KEGG" id="tve:TRV_05733"/>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="76953" checksum="13D9608AAFA6DAE8" modified="2010-05-18" version="1">MSVVGIDFGALSTKIGVARNKGIDIVTNEVSNRSTPSLVGFGPKSRYIGEPAKTQEISNLKNTVGSLKLLVGRQFSDPDVQLEQEFCSAKLVDVNGEAGAEVSYMGKKEQFSATQLVAMYLTKIKSTASAELKLPVSDVVVSVPPWFTDAQRRALIDASAIAGLNMLRLINDTTAIALGYGITKLDLPAEGETPRRVAFVDIGHCNYSCAIVEFKKGELNVKGTAWDRHFGGRALDKALVDHLAKEFKEKFKIDIKTNPKAMTRTFAAAEKLKKILSANAQAPISIESIMNDVDVRAMVKREELEEMIRPLLDRITVPLEQALAEAGLKPEEIDSIEMVGGCTRVPSIKEAISKFFGKQLSFTLNQDEAVARGCAFSCAILSPVFRVRDFSVHDVINYPIEFTWEQSPDIPDEATSLTVFNKGNIMPSTKILTFYRKQPFDLEARYSKPDMLPGKTNPWIGRFSVKGVTADANSDFMICKLKARLNLHGILNIESGYYVEDVEVEEPIPEEKKEGETMDTDDANGEAEAKPKMRKVKKQLRKGDLPVVVGSTSLDPAAREKLAERENAMFMEDKLVADTEDKKNELESFIYELRDKIDGVYAEHASEEEKEKLRAKLTSTEDWLYEEGEDTTKAVYMSKMDDIRFLSGPIVQRYLDKLEAERQAAAPKKHVEIKGDTVDNADANGDSKMEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF77</accession>
    <name>D4DF77_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerophosphocholine phosphodiesterase Gde1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000335">
        <property type="protein sequence ID" value="EFE39504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020128.1">
        <property type="nucleotide sequence ID" value="XM_003020082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF77"/>
    <dbReference type="GeneID" id="9583892"/>
    <dbReference type="KEGG" id="tve:TRV_05822"/>
    <dbReference type="HOGENOM" id="CLU_005444_1_0_1"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="801"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124624" checksum="FA4A58446C777BAD" modified="2010-05-18" version="1">MVPEWSSSYIKYKSLKKLIKSAVQAKKMGNDPDLADYTNTTPGFFYSLDRNLEDVDSFYNKKFSDCSRRLKLLEDRFGHPETLPSHLDPEDTEDLMAALLELRGQLRKLQWYGEVNRRGFIKITKKLDKKLPGANAQIKYLSTKVNPALFATNSRLLHSVNSINEWLSVLGHEKVMDDNSSTHSALSLKKPSSGVILNLPTSLLLSVDDALRRDDTNALLDLLPTLKTAADGIGEAVFTKVLISLQQRSIFYRSKACLAALLQRVTSLEEEDDINKRNCIHRLVISIGRSQSTVDPESSATMVLNFPTETSNYITPATTPTLKPQRPVVMESDHPTHIGRDSPVVMFLQYLLDNLLPHQRPALLARDISGKTPLHFAAQYGFKAVCDVIIEHLQEWDMFDVSEGIDGPLWQDEDGMAPLHLSVVGGHPLTTKTLLDSENWKGSNQDKTAIRRNILKSSAVLALATKANFVDIVHLLVEAGVNINYQDEQGETALHSAARFGHDQCAAALLKGSDEQKANVELAENTYAWTPLFIASVDGNINIVKLLIEAGANLEATDSSGWTAKEHATLRGHIDIARLLDEAMATSDGSVESDTASQSAVSSSPPSQCSLNDRNSKDRAPDAVKSFGHRYLTDKSMILVSLGTMDMRKTADPVSLERIPMAEAHLTQLDTALSIVVSASGAHGEPQIIDLPVQDNISTEPIVFHTADSSKTKIVFDLVPTYAGSKDEVFGRGVALLSSFKPTVGSSRSNLQGDFVVPLIAAKTLEIIGSVTFNFLVITPFSHPKMSITEEQTYWKSVTSPMVIGHRGLGKNIAGRHSLQLGENTVQVCLNLLQIFDFPNSRPSLLSRLQTWALHMLSETGIDAPVHTLTLEQFLHISDGRKPAGKQSSNHSGTPNSEDGFPRLLQTRPRSMSVGEELDVPNLSERMKHTRDFKKKGFKGNSRGDHIQAPFATLEELFKELPKSAGFNMELKYPMLHESEEEEMDTYAVELNSFVDNVLRIVYDHGEGRNMIFSSFNPDICLLLSFKQPSIPVLFLTDSGVSPVADIRASSLQEAIRFASRWNLLGIVTNAEPLVLSPRLVKVVKESGLVCVSYGTINNDPANVKIQVNEGIDAVIVDSVLAIRQGLTGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF89</accession>
    <name>D4DF89_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab geranylgeranyl transferase escort protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020062.1">
        <property type="nucleotide sequence ID" value="XM_003020016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF89"/>
    <dbReference type="GeneID" id="9583826"/>
    <dbReference type="KEGG" id="tve:TRV_05835"/>
    <dbReference type="HOGENOM" id="CLU_021695_3_1_1"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="412" mass="45598" checksum="F27C059EC01567C5" modified="2010-05-18" version="1">MLDLNTLDGSTWDVVISGTGLPQAFLALALSRSGKKILHIDKNDYYGGSEAAFSLQEAEEWVKKVNEDGEDDELSFSRAYTLSLSPQLLFSQSRFLPSLVSSRVYRQLEFQAVGSWWIYQYSTGSEANSQPARLQRVPSSREDVFTDETMSMKSKRSLMKLLRQLMQQDHDQENEAESEVDQNMQFQNLLETKYRIPSDLFDPLLSLSLSLKSMDTTNSMDAIPNIKRHLSSIGVFGPGFGAVLAKWGGGAEFSQAACRACAVGGGIYALGREIKKVDEITDGGQSEKLHIYLTDNESVKSRYVVGSGWDLPEQIHRERVHPYSRLTRAIMVVNSSLEILFPQTSENGPVPAGAVVTIPSRNSGPPAYLLVHSSDTGECPANQSITLIQLSFHDAFILSTLSAKSLMITSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF99</accession>
    <name>D4DF99_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020072.1">
        <property type="nucleotide sequence ID" value="XM_003020026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF99"/>
    <dbReference type="GeneID" id="9583836"/>
    <dbReference type="KEGG" id="tve:TRV_05845"/>
    <dbReference type="HOGENOM" id="CLU_038716_0_1_1"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055488" description="6-phosphogluconolactonase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42512" checksum="193B71D939927153" modified="2010-05-18" version="1">MKTVPFLSLLQAGILTSGIVAQNIAFVGSNANAIATVSFDTKTGTFKVTGNNTDSSTPSWQEVSKDGKMLYSIEETSTEHALTSYSIGQDGKLKKLKSIKGMAGPVSLDMHPTQPIIITANYGSASASAYSSKDNGEFTHLGDFMFKMQGKGKVPDRQDAPHPHQALFDPTGKFVLMPDLGSDLIRILKVDAGQKFSVAPPNKVKPGTGPRHGVLYPASDKPRFYYVVGELSNTVTAMSVEYTVETIKLTEIQTLSTLPDGQTGAAGELILSPSGKHLYASNRLDKVFPGSSSVASYTIDQMTGKLKLLEIFNGGVENIRHMSIHPSGKWFVTEGQNSNDIKVFALDPETGKVTPEAKSTLEIEKPVCLQWWHNGAQESEAPEAGTETECEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFJ3</accession>
    <name>D4DFJ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019975.1">
        <property type="nucleotide sequence ID" value="XM_003019929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFJ3"/>
    <dbReference type="GeneID" id="9584729"/>
    <dbReference type="KEGG" id="tve:TRV_05944"/>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34145" checksum="470710317BA51AC6" modified="2010-05-18" version="1">MNIEDRIIENEDLAEEIDAVNAIYDPSTITPTSSSPHAELAVKYTIILTIPNHETVSFLLGFDSNYPTTPPRVLGPASSGARGEGKRYADILADSVKRVWTEGSVCLYDLIVDAEEQFNEIKSAQNEKEKNDNTPPTEEPSTSTLEEKDIHSLGLATPPPWVISDPITEKKSVFVARAATVESKEQAEKYLDHLLATEKKVASATHNITAWRIRQSQQSSNDQQQQPGRDTVVQDFDDDGETAAGGRLLHLMQLMDVWDVVVVVTRWYGGVKLGPDRFRIINAAARDALIKGGFEKAQSTEKGKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN3</accession>
    <name>D4DFN3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HDA1 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020015.1">
        <property type="nucleotide sequence ID" value="XM_003019969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN3"/>
    <dbReference type="GeneID" id="9580184"/>
    <dbReference type="KEGG" id="tve:TRV_05984"/>
    <dbReference type="HOGENOM" id="CLU_004103_0_0_1"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81437" checksum="B3D937E030C36903" modified="2010-05-18" version="1">MKQLWDSDRALTKPLNSLPQSTTSSSAGDILPSAPPNASDIISPLDSQLDKDTANAIGNEAPSSVPIPFVTPQALHYNVEQVTSVPEALEPTVQTETTELDASSPQEQNQDALELEVNILTLSEMEFAIPLSMDCRVKDEYDNTLEGENKYVEKFLELSPQSSDMGSLEGDSQGLITRMATLVEKLDNITTHPDIDIASQAAGASPDTAKEALWAEYSSSKFQYLGYLIDASNELDLHIIIMAKPGRTVDVVKRYLMGKNFNQAPFPGGEHGDSPAIFSKEKVSFEVRSTTDERGMLASRLPSLIIALDSSFDVNLEPVKKLRVAHGHSTLVPVVRLIIANTVEHVKACLPKCTELTRLRLLVQHTLACNDSSGELQDDALGVQENAEETLMYVMDNPATRTWKLPFMEALEIEGQGETPGSELDPTSSTNASRQKRWLESELSDSTNPSKRQRITPTQDITHVSDSVRDLTQTDQNSNPSATQGHTNQSATDIEALRNALMNSKAKVKTLEASIGALQYRYEAKHNLLHQTRHELEIEREKSQKLQTRFERQKEEITRLKDRNAELVTELEAARNTVKSGGGLESDLENSREEIRKLEKTMASLERTVQQERSQTEYTRQQYQNASTSAAQSAMEARRLEERVQELEKKANGEAVRLKELKMKKDGEMQLARIKELESLLATRETLLTRKEEEIREMKKNRPSTRATSMQPRSPKLEEKKKKKKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR3</accession>
    <name>D4DFR3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019913.1">
        <property type="nucleotide sequence ID" value="XM_003019867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR3"/>
    <dbReference type="GeneID" id="9584664"/>
    <dbReference type="KEGG" id="tve:TRV_06014"/>
    <dbReference type="HOGENOM" id="CLU_050424_0_1_1"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="211" mass="23228" checksum="5E4503EACF4ADF5D" modified="2010-05-18" version="1">MQLFLIGFIIISICEIFSVGAFPLSDSIRKGFSAAHVAAICATAWLLLLNAIVGYQLIDDGTAVSLGLLVTSALILFVGTGYIALDTAFAWTGRFQSSHRAPNQNIGLYILYLLFPLICIVGFFLLETFLVVKVLKEKRPMLYLSIAGLLFALSQIFQFVISTHLCNATDGKINGAFFETLFNFGAVIMVWVFWSSITEDDWPMNVNGAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFS9</accession>
    <name>D4DFS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019929.1">
        <property type="nucleotide sequence ID" value="XM_003019883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFS9"/>
    <dbReference type="GeneID" id="9584681"/>
    <dbReference type="KEGG" id="tve:TRV_06031"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_3_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38668" checksum="F89B995F86788EF8" modified="2010-05-18" version="1">MDGTIILTGATGGLGKELVKKLLRRPGSYTLIFPGLYQKTTQAADLQRIISSHGKRNHVASIPEVNLARFDDVRAFVSGINRTVSAGTIPPIRALVLNAALCYDLSGIRLTDQTGEKQHPPFEMNFAVNFLANVLLSLRLLQSMDKQHGRIVYTSSCTHDSRRPENEYYKPDKLKWDVAELAHPNMHNLDKDAAMESMRRYGASKLALVTFMHALRKRLDKTPDLNNISIAGVDPGAVLHDNIVQRASWTNRNFTFPLMQLYTRWLAQHLWPNGLFRTAEKSAQDLLSAALEPKHSWAHPTEAYFNGSEQAEAAVEAKDEKRQQELWGLSLHYVGLDDKSQTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG53</accession>
    <name>D4DG53_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G1/S-specific cyclin Pcl5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019778.1">
        <property type="nucleotide sequence ID" value="XM_003019732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG53"/>
    <dbReference type="GeneID" id="9583701"/>
    <dbReference type="KEGG" id="tve:TRV_06155"/>
    <dbReference type="HOGENOM" id="CLU_015683_1_0_1"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="689" mass="73706" checksum="D660191A2F1BC267" modified="2010-05-18" version="1">MSAFVDILGYNPVNPGLSKPVHQTCPYAASLAVSAPPSASSIFSLDAVSSQPSVASSSSTADVIWENEGTADAQHKKAAVKTCFGKGAETRHHPRRTVATRPPPTLVRQCERKTNFVDSLVDSASQIVEIIWPLSVAAAPRSVESTLGCKGVLPLRTFIQETLRRSRTSYSTLQVALYYLILIKPHVPSIDFTMEQPKLQQSHSRAMQCGRRMFLSALILASKYLQDRNYSARAWSKISGLNTAEINQNELMFLQAVDWRLHISDAVFQRWNDIVLKYTPNASGIPSTDGMCWRTVIPILTPELDTLDSRAEGPWSLSSVGSPADSSSASSASSSSSSPSSTSTAPSSPASCDSPSSGLPFAEMPRRPSAADLSGVTLPPLPRLGLLPTPQLTPQVGMTAPAPAASISACRPSICSALSQAQTAFVQRTTLDQRPTQPLYISKQPSFDCSSSGSFQGRRSSLARSSSFTSSPESMASDAPSLSFSSQSSRSSRSSSISSVTSMNCATRPTRRNTPTSQPTNCLKENRKPLAIATPIDEHEPSYISNYPSPPLRTSSAFSTASSTVPDLSNFSINTPSDPDAAAIQGLYELATGLSLPMDSSLSKASRHCRKRTRAPSTSEGTNLQQKVRHLMALDARDLEDEGTSLAVLSDSQVADSFLVNKVAGMGDSRASSKRACSGKENVRTLWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP3</accession>
    <name>D4DGP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019630.1">
        <property type="nucleotide sequence ID" value="XM_003019584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP3"/>
    <dbReference type="GeneID" id="9580160"/>
    <dbReference type="KEGG" id="tve:TRV_06348"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055564" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="457" mass="50591" checksum="2160C7A656BE3C81" modified="2010-05-18" version="1">MKLKRLSFLSPRWVVLLLLLQSWLASAIKLDLESDDSIKLAAKTAAEAMMKYYTGHQPGGVPGNLPDPYFWWETGAMFGGLIDYWFYTGDSQFNDIVTQGMLWQVGPDSNFMPPNQTLTEGNDDQAFWAIAAMSAAERKFPNPPSDKPQWLSLVEAVFNSQIPRWDTATCGGGLKWQIFRFNRGFDYKNTISNGAFFQMGARLARYTGNETYAKWAEKTWDWSRAIGLINENYQFFDGSSDTLNCTELNRLQWTYNAGVYLLGAAAMYNYTDGSPKWAERVQGILDGLRPFFHPETYIMSEISCEEQGNCETDQRSFKAYLSRWMAASTQFAPFSTDFIMRRLRACARGAAKACTGGEEGTTCGLKWTTGKFDGSTGVGEQLAAMEIFQSNLIRKVVPPVTQSSGGISLGGPGGSGKGKDNGPKILRPITGADTAGAAILTLLMFCSLSGVSYWMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGV7</accession>
    <name>D4DGV7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019538.1">
        <property type="nucleotide sequence ID" value="XM_003019492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGV7"/>
    <dbReference type="GeneID" id="9578312"/>
    <dbReference type="KEGG" id="tve:TRV_06412"/>
    <dbReference type="HOGENOM" id="CLU_337453_0_0_1"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="92827" checksum="C5DA3E74A6823539" modified="2010-05-18" version="1">MTTPQLTEDKIKIDAAANSNPVDNGSAKATCTQAPAGPKNKNQTLGEADISMDDIDTGSGPHENGTGGPTQANEEYRYSSSSTSQPGSRGSSGNTEYGEGEIDDFPYDDEFEDEDKSFVSDLRGGGREIRSARTSISSLPGSVVVFPNNKPAGSGQLSRGDYRQNINTNASDRNPMFESPLSGGRVRSKKKIAKDGRYSYAPHVRGLDSPFRHPSSVRAMQMGDEDYYDDGCMDDGNYFSSPLSRNGRMGGRQHGSPRMSDASFRSRPMSPSDQRSYHASPPQPIQPSKEYALILLHCTLLPPCFPLSLPPGLPPPSKELLKEILPDAYWTRWKLLEEKIGSTGLLRDRGILISHPQEAYDLLEERLLETLGLTRPRLAYGHFIGGEDDTDEDEQVTEDEDENNDTETGCVKHKCQDCGQKLIMNRDGVEKKWEVRVYAANGLMGQGAWSAAWKEMEKVDVEVGLCLPTKLRNELEQRLAQEMLRPEAKVKDFPLQESKASEIPSARLQSQIDGLDEPPQAKPTAKSPARERGRIASTPKSTQYSRDDVNLWKALFDYIRIVCRGNQLPIMTVFLVLLALLTPSPYHLFGHSSSDVTIPQLDTISLDQASIMPMPTSGAEEVSQPPVSSEEIVESSWPVIQELPTASYSEASSQETVSAQLDSSASHPRFQEQKTSSDLDLLLDENPSAETIVSTQSGLPMSDYQQPKDTTIPSQPDEPAFSVLPASPDYPTQQDQPSPSHTPSSSSYTTSSASPSLPPVGNGEQPVDTQDFLHYSVSQGHAPISTDAAAPEVEVTRDETYESVSVPPQSTPAPTSAVMEKGNGLQFQLSPHEKVVRADSEPSTDEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ2</accession>
    <name>D4DGZ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000365">
        <property type="protein sequence ID" value="EFE38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019522.1">
        <property type="nucleotide sequence ID" value="XM_003019476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ2"/>
    <dbReference type="GeneID" id="9578219"/>
    <dbReference type="KEGG" id="tve:TRV_06447"/>
    <dbReference type="HOGENOM" id="CLU_2856138_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="65" mass="7225" checksum="69C6A86C5661E793" modified="2010-05-18" version="1" fragment="single">PASYLHGGSHSRSSNKSEQGMKNLQSSKRLSRPKQGKEIDKQPSNSFTFAVITAMAVTVYLEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH77</accession>
    <name>D4DH77_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019452.1">
        <property type="nucleotide sequence ID" value="XM_003019406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH77"/>
    <dbReference type="GeneID" id="9577902"/>
    <dbReference type="KEGG" id="tve:TRV_06532"/>
    <dbReference type="HOGENOM" id="CLU_095741_4_0_1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="157" mass="17934" checksum="7CE5DA2C78B30B0E" modified="2010-05-18" version="1">MDLEFDENGFYILLSDRGDSWRFHWGLYLAKTKTSGIVYHLVNDTPSTDWRLEVKESSNVLQSNKLLGALKIGIIEPMLHEMLGQCLMEIPIEYSTRFKENITCRVWLKEAVHELNERGLLNIHESVDSIEFEANSIALSSKATKKKSVQLSMGTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHF0</accession>
    <name>D4DHF0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000379">
        <property type="protein sequence ID" value="EFE38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019377.1">
        <property type="nucleotide sequence ID" value="XM_003019331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHF0"/>
    <dbReference type="GeneID" id="9577780"/>
    <dbReference type="KEGG" id="tve:TRV_06606"/>
    <dbReference type="HOGENOM" id="CLU_1385076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="197" mass="22423" checksum="522DFB0109009ED9" modified="2010-05-18" version="1">MARGDRGAVAERSGSRCLIGRDGLAGGDLILDIDEGEEGEEEDEDEDEEVDEDNEVDDGEEQRRCEEQQTRRDDRLCDCSGPLGGWEKTPAACIPESTKPPLRKKILKKALKKDEEEANKKKKKKRRQEKKASLLLFSFSCPLPVLLLGSVLRSAMQMLMLMLIRVYRDTIRVPTQRPYSRPKTKTKMEVDEDNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ2</accession>
    <name>D4DHJ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019304.1">
        <property type="nucleotide sequence ID" value="XM_003019258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ2"/>
    <dbReference type="GeneID" id="9577626"/>
    <dbReference type="KEGG" id="tve:TRV_06648"/>
    <dbReference type="HOGENOM" id="CLU_083369_0_1_1"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056509" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22746" checksum="43CCA014FFE353D6" modified="2010-05-18" version="1">MKLSLALLGLAASQAVGLAIPDATPETDVPDVLTLTERHHGGSGCPSNTQTVRYNVANDRRSIVIQYENLTARINSKTTPADERTNCQVNLQVAGRNNYQFSVASATYYGSARLDAGVTGRHGSIYYFSGSPDQAFTATGISGPRRGNYRLDDDANKRIWSPCGESYPFNINTDVRMDSDNDNATGEMSREDGADGTVKQVISLDWRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHP7</accession>
    <name>D4DHP7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019299.1">
        <property type="nucleotide sequence ID" value="XM_003019253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHP7"/>
    <dbReference type="GeneID" id="9577621"/>
    <dbReference type="KEGG" id="tve:TRV_06703"/>
    <dbReference type="HOGENOM" id="CLU_047429_0_0_1"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="305" mass="33719" checksum="7580E4BA60A70556" modified="2010-05-18" version="1">MDVDAPLFNPAKRRKFMRRRADDTRPEDEVEAKASTPTAPDTPASSAPDGVETDEMGVADILRLRKNKARKGGIEFSTSRSSRSDALVPAAETTAEGRLSGISDRFVGHSGQKVDVDKHIDPTNPADGQNQSRQAAEHTSAADLQLPQRQPATLGKLHEIDLGPDSKLQNIARTEAATRNLAKGDSAAPEDEETVNKGKQTRGGRRRRNSEDIMRDRLVEEVLRESKLDVYEEPQSHLDEDDQAADDRIADQFRRDFLDAIHSRRRGARTRNTKTSKTDAPRGPKLGGSRSARAAMREQQNKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV6</accession>
    <name>D4DHV6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019214.1">
        <property type="nucleotide sequence ID" value="XM_003019168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV6"/>
    <dbReference type="GeneID" id="9577211"/>
    <dbReference type="KEGG" id="tve:TRV_06763"/>
    <dbReference type="HOGENOM" id="CLU_076387_0_0_1"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23628" checksum="D9FF94E4CE494FA1" modified="2010-05-18" version="1">MASVKSALRPAGCCANAFKELRQQVPRRQFLHTVHSPRKEKIAFPTTIPEQFISQIPKFCRPGKGTKELKVHPPPAFPYDTCKDPIAAFTAEQLSVLDPTGERKALFDPKNRQGAKVGDILRVTFKNGDPFAGVCLNIRQRGVDTAFLLRNKLTRISCEMWVKAYSPNVVGVEVVQRTEKRKRRAKLTYMRYDYSPHFVIIIAENIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHX6</accession>
    <name>D4DHX6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019177.1">
        <property type="nucleotide sequence ID" value="XM_003019131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHX6"/>
    <dbReference type="GeneID" id="9577174"/>
    <dbReference type="KEGG" id="tve:TRV_06783"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_4_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="248" mass="26989" checksum="BA19165B98115A2A" modified="2010-05-18" version="1">MAAPKITLYVDIVSPFAYIAYHVLRNSPVFAKCTTTYVPVLLGGIIQATGNTPPIRIKSKPLTRPPLALLNLLLQARLISYILNPADKDKWINVERLRWSKLLGVPITEAMPDGFPVFTLAVQRALCVVAADHPEKLAGCIDALYNTLWVKRDSSVIKPEGYVPVLETVIGKDAAIKVAEKSNTAEIKQKLVSNTDRAVESGAFGLPWMECTNSKGETESFFGVDHLGQVVAFLGLDGTLGQGFKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI51</accession>
    <name>D4DI51_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000395">
        <property type="protein sequence ID" value="EFE38475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019120.1">
        <property type="nucleotide sequence ID" value="XM_003019074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI51"/>
    <dbReference type="GeneID" id="9582603"/>
    <dbReference type="KEGG" id="tve:TRV_06859"/>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="8756" checksum="7F672A63742B2F44" modified="2010-05-18" version="1">MENEKGEIVDLATNRIIKAKDHASVQISIAKVDENGRYTGENQVYALSGFVRAMGEGDDSLNRLAQRDGFLKNVWSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI87</accession>
    <name>D4DI87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019070.1">
        <property type="nucleotide sequence ID" value="XM_003019024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI87"/>
    <dbReference type="GeneID" id="9582555"/>
    <dbReference type="KEGG" id="tve:TRV_06895"/>
    <dbReference type="HOGENOM" id="CLU_019101_0_1_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="46287" checksum="19359D880A5628C3" modified="2010-05-18" version="1">MLPTSPAEVAAAQEAGRKATIEIWTLFAIGFTATMLRIYARIHAVGVRNLRPDDFLVLVALVLYAAQSTLGYHVGTKAHGLANNFKLDSERAALPVNSIEYEFRVTGSKIQLAGWTTYTWLISMLKFSMLAFYIRLTEGVGGTYRMQIFIGFGLVAGTCMASLLTIFLSCRPLHKYWQIYPNPGNACQPAVSKPVVWVSFAANIITDIYLILIPLPMLWRSTLRTIKKIAASIVLGAGIFVLVCACLKSIFVLVNPVHGAQLAGAWGVREAFVAVMVTNLPMIFPLIRAMLSPWFSKLFSTQKKSSYKTPGLQTIGGTPHGGNSSYNNNNNNRSKGRRQPQSDITTSFTLNGSDERIMHDDVKMQDLKTFNSIDNEPQEPLPARGIMISNSVEIMHEDRGSLHDEEQQRVENVREVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI99</accession>
    <name>D4DI99_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019082.1">
        <property type="nucleotide sequence ID" value="XM_003019036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI99"/>
    <dbReference type="GeneID" id="9582568"/>
    <dbReference type="KEGG" id="tve:TRV_06907"/>
    <dbReference type="HOGENOM" id="CLU_1152456_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="27859" checksum="DB003E0F4FB5D9E5" modified="2010-05-18" version="1">MDVSTDDELLMYDKLHGTNICVEPMNFDYLDVVLVSEFDFMERRERRRMGGPTSPSCVLSPSENASTETSSDSFYERVKRPRYPCVGQTWYVKPWRHPGFFFSSLSDTYRNTRRPHFPIPKPESRKRHRATFGRYYSSEEETETEIPRSDTSHRTRTGYRKHRRAVPEQNTSEDVNIIIDLYLNIDPELQAKVSYGKQKSGDCVLGNFIKSPVDVSAPEPEAQRVGLAVGLAAGMVFRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIB6</accession>
    <name>D4DIB6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000402">
        <property type="protein sequence ID" value="EFE38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019053.1">
        <property type="nucleotide sequence ID" value="XM_003019007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIB6"/>
    <dbReference type="GeneID" id="9582538"/>
    <dbReference type="KEGG" id="tve:TRV_06924"/>
    <dbReference type="HOGENOM" id="CLU_010862_2_0_1"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="782" mass="85093" checksum="1D244BF32271FD21" modified="2010-05-18" version="1">MASAEEMPKLGTILSPPKQGQLIKHGSTVYKTIQEGLAYILVDQKDAEPAKPPPLTQNQKTTEGDRPSVFYNPIQQFNRDLSVLAIRAYGEHATAIKQKKRKLKLKGRKTPTKKAKADEGNETEKPIETDAPSVGDQVKAESVGAGVNKRRREDEETPAENTPLKKTCTETRSNGEDMAGPVGEEIAMQAKDVIVTEHTEKVAENAAPKPWTPSFTILDALSASGLRALRYAKEIPFATRVVGNDLSAAAIESMKLNVQHNGLEDRVHPNKGDACAYMYTVGRAQGSPNEPGGIPKFDVVDLDPYGTAAPFLDAAVQSVADGGLLCVTCTDAGVFAGAGYPEKTFALYGGIPIRGSHSHEGGLRLILHAIGTAAGKYGLAIEPMLSLSIDFYARVFVRIHKAPIEVKFAASKTMISFNCDHGCGSWKTQRLAERKPQTGKDGKTFYSYGLAQGPTAAPNCEHCGFKTHVAGPMWAGPLHNPVFIQRILDLTAGADRDTYQTCPRIEGMLTTALEEDLDLGGSAKEPTPEAEPVQPNTNSQETSLLIPRVDPALIEPYPFFFIVSNLARVLRTSTMPEIQFHGALRSLGYKSTRSHAKPNSIRTNAPWEVVWEIMREWVRLKSPIKPGALSDSTAGAGILRRNRHTLNPIPGEVPGLKALKRDLLTAVDSGRSIADITMMVQAALYRSGVHQSIEIVDRHTLEGMEKNESNNEVQSNDSSTRAGSPSTCQDPSTLNVVFDGELGKKALNSHRRKRLKRYQANPRPNWGPIARAHVTNTTKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIG6</accession>
    <name>D4DIG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018963.1">
        <property type="nucleotide sequence ID" value="XM_003018917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIG6"/>
    <dbReference type="GeneID" id="9582123"/>
    <dbReference type="KEGG" id="tve:TRV_06974"/>
    <dbReference type="HOGENOM" id="CLU_082438_3_0_1"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="157" mass="18159" checksum="D3B81C60BF270213" modified="2010-05-18" version="1">MSQEIDIKPSTWKLVEVGRVVLIRRGPYADKLAAISEIIDHKRVLVDGPSGDEEKAVPRQSIPLAHVTLTSLCLDKLPRRARTGAMRKAWEKSGIDAKWAETGYAKKKEQQDRRRNLTDFERFKVMRLRKQVRLLLFQARHDYACRTYGDASYFMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIM3</accession>
    <name>D4DIM3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019020.1">
        <property type="nucleotide sequence ID" value="XM_003018974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIM3"/>
    <dbReference type="GeneID" id="9582425"/>
    <dbReference type="KEGG" id="tve:TRV_07033"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_1_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="346" mass="37905" checksum="A0DE85655D1A5FDC" modified="2010-05-18" version="1">MSQKLNVAIAQCRTRDTLTETLNALEQVTIKAANRLANILLFPEGYLGGYPRGCNFGAAIGSRNDAGRDQYLEYFKAAVDFGDTPIPSEDDWVKRKLPVAKGKNYRGDGTREFLEQVARENGVLLVVGAIERCAGSLYCAVVYVDPKKGMIGKRRKVMPTGTERLVWAQGPASTLKAVTTEINGVKLTLAAAICWENYMPLLRQAIYQQNVNLYLAPTADGRDTWLPLMQTIALEGRTVVLSANQCLKRSHLPSWVTNDIKQEGKDSSDDAFVTGGGSCIISPAGKVLAGPIWNVTDEDEESLQVVEVDFEDCVRGRLELDVAGSYSRNDSFKLTVEGLDLNPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIQ0</accession>
    <name>D4DIQ0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018928.1">
        <property type="nucleotide sequence ID" value="XM_003018882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIQ0"/>
    <dbReference type="GeneID" id="9582088"/>
    <dbReference type="KEGG" id="tve:TRV_07060"/>
    <dbReference type="HOGENOM" id="CLU_030267_0_0_1"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="45431" checksum="EA96F695D8437328" modified="2010-05-18" version="1">MNSANVTKNTHGKAEGEEEADGDEIGGGLDIMRTTGQQAGGQRLKVPDRAIASALNQQRKKTRRRKGSLRKTALLGTGMLRMEGKERFAGGGTTLKRATGIFLDQYDGPAEIEEYKSREKGELEKDGERSREAASVVTNDSKKLSRLQRQLSASLDDGESTPRRFSHSSTLAADHESPSSASPSSWNQNQWKQQQHGQQLQHTPTNSGSFSNAAQVGQSSAANSVQDDGTTDDEDGLSLPRLNTSNLSRLSSKTSNSSISASPVLPPRRMPLSALQTAASSSSDSFFKHSSTMAQISRSSSQRIRSPLATSNTAEITSPSEVWDYSETEWWGWIILIVTWLVFVVGMGSCLGVWSWAWDVGETPYAPPELEDDATLPIVGYYPALIVLTAVMAWVWVVVAWVGMKYFRHANISGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJA9</accession>
    <name>D4DJA9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoric ester hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000431">
        <property type="protein sequence ID" value="EFE38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018705.1">
        <property type="nucleotide sequence ID" value="XM_003018659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJA9"/>
    <dbReference type="GeneID" id="9581024"/>
    <dbReference type="KEGG" id="tve:TRV_07275"/>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF28">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="33135" checksum="33178DE79FFC2B72" modified="2010-05-18" version="1" fragment="single">MVWRRNGGLDALVRRPVPTRWNRFITSPISFLASLIYEWRSSIPTRSIATISDKAITVVCISDTHMTRPHIPDGDILLHSGDLTQSGSQDELQQALDWLNTLPHQHKVIVAGNHDWCLDPSLKTSKTLSHSGAPQKFIDWGNIIYLQNTSATLDCCGRNINIFGSPVSPKHGNWAFQYPRKENVWEGIIPPNTDILLTHTPPHSHLDLSFGCKFLLQELWRLKHRSILHVFGHIHGGYGQHMAYFDKFQSIYESIIKGDASIISLLFLIYEAMKVLLWRAPTQGIWMVNASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJG3</accession>
    <name>D4DJG3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018641.1">
        <property type="nucleotide sequence ID" value="XM_003018595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJG3"/>
    <dbReference type="GeneID" id="9580792"/>
    <dbReference type="KEGG" id="tve:TRV_07329"/>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="620"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="862" mass="97338" checksum="1BD77698EBFFFAF6" modified="2010-05-18" version="1">MRRPEINTTRLPKQLREELGLKDSRDSGRPNRGRGKPLSRKERRKEERSQKKQHHQQPRKLVQRHVRDDQDRDRDPGTEASLDDDAGDRELRTTIPAKPEPKSILKKRKRSDEAQGTKKNDDADVALPERKIPRAVREKLEEDDREIARLEKALGLKGKKKLPKSFEEDGLAEILGDLGGYGSESDQKRGKQDGEEWLQSKRRKAQAQAQADMSLDEDSGNDFDSDSGEDETDEDDEGLLDELEEDDESSEEGSMDEFEGFDDEPEQPPKRIKENPYVAPVAPSSKDQPKYIPASLRVAAATESEALIRVRRQLQGQLNKLSEANLISILSEIEKIYQDHPRKIVTTTLIDLLLALVADRSTLNDTFVILHAAFISAVYKVIGMDFGAELVQRVVEKFDEIYEDKNSSDHASKSKILSNLMSLLSHLYNFHVIGSSLAFDYIRLLLTEINELNTELLLKIIKSSGSQLRQDDPSSLKDILMLVQPAVARVGEAALSVRTKFMIEIITDLKNNRLKTGIAGTALASEHITKMRKVLGTLNNRNLRASEPLRISRADIHNSSKTGKWWLVGASWKDPSMTDDHSNDPSAGRDATMTDTLDVDITGGEVDLGQLARAHRMNTDVRRSIFVAIMSATDCRDAYLRLTKLRLKRNQETEIPRVLMHCATEEEAHNPYYTLIARKLCGEKRMRMAFMFSLWDIFKKMGERGHSEEDDDFSGIDAEDEENALSTRAIFNLANMFARLIAEGSLSLGILKILDFPYLQPKTKTFVEILLITVMTQSQQKSHKKHKNKDNADDGYDEKALVTIFMKTSETPQVVAGLRYFIRKVVTKSDVVTSKRDKKLVKWACKTALDTLSIVAEGGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKB4</accession>
    <name>D4DKB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-Methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000463">
        <property type="protein sequence ID" value="EFE37701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018346.1">
        <property type="nucleotide sequence ID" value="XM_003018300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKB4"/>
    <dbReference type="GeneID" id="9584274"/>
    <dbReference type="KEGG" id="tve:TRV_07636"/>
    <dbReference type="HOGENOM" id="CLU_008691_0_0_1"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="790"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="95523" checksum="5E9B0942B9E629A2" modified="2010-05-18" version="1">MPSKSREHHRPRDRGSDDQSSEATEGTAKPSHPSRTREKDKDRHSRAAHTSSHSSSKRTRPRSDKDRLKDEVGRSPNSPTSSLKIKKHPSTTLMSETNELKVSTPYPSFSKAHSKEAVGSRDNLGIRINILTPEPTDLTSAEAKKDEQKPSLTTEDKTQSKRHSQSTRPPSPPLTNDDTELPRWKSTPSNDGRRSEEKETPNKSSGEAKKHRSSRSHSTRSSAGIYKKLSDQTLKTSTRTRSSTPTKLKIFEALQFSHRSSPTSAHRKSKSSLNRKSASPAEAESDNEIIDETVDSDATSIAPVQVKTTEQLPKLRNRPRASRPPSHASPSPRPDVLTQETLRDPSAASPPPPPPPPEIPLSRPRVDYLLQNGGLPYHVPRNFLGAGESANMPQHLFEPANTGMKLFEPFSKLLSDYSRVIEKNGSLAVATGYRSVARRLLDRLESVFARDISSESCECPMCCGREENEVQPGVSWGEVLELVSGRGELPTWPPFRMQPELDPATIENTQEHIPMQKLDIDVPEEYRDHYIRQSRKTKQAVDKWLSRQPDQPAEPPGEVDDETLTFAILTYLDPEQRAPFASLLEFPLGPAVPKKETPKPPDRPPCLVLGAIAIYRLYRLQSLPRDPETALYMVKHPDMHNVLATLAAISDDEWDILISGRFDGFLRSGAEDNSVPTSATEPPFDPHSSFQRNGNQTMRSASQPRAGASISTAAAGTYGAPISIDEETEIAALAEVERDIFLGMEALEDAFEILHGKAEMVRRALRERGAGLTAASQARRGCRSNIQILAGTPVPMGTPAEFESGTDEDVDDGASIAPSESASNISSNRRRRPKRRTERRTPAPVEEEPDEYNEYVVPIRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR0</accession>
    <name>D4DKR0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018209.1">
        <property type="nucleotide sequence ID" value="XM_003018163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR0"/>
    <dbReference type="GeneID" id="9579580"/>
    <dbReference type="KEGG" id="tve:TRV_07784"/>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="26858" checksum="8DB53B967BC0C9D0" modified="2010-05-18" version="1">MPAIPKESDFPSSVSVTVTPPDSPRSTNVLIILHGLGDTPAPFTSFASALHLPETSCVVVQGPVPLPFDLPGFHWGDDIVFEADSLDQDPGFTRATRMIAADIIRSTLIDKLGYKAREILLFGFAQGASVALSAALEFHLSETGRGELGGTVAIGGVLPLSAIKERGSRQNKSPSPVLVLGGHGAQSAVTDVGVRRTKEEFEYVDVVRWRSKKEDTMPRNRDEMMPIMQFFARRLRSTSGVPEGSVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL09</accession>
    <name>D4DL09_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 alkane hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000487">
        <property type="protein sequence ID" value="EFE37462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018107.1">
        <property type="nucleotide sequence ID" value="XM_003018061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL09"/>
    <dbReference type="GeneID" id="9579315"/>
    <dbReference type="KEGG" id="tve:TRV_07883"/>
    <dbReference type="HOGENOM" id="CLU_1035074_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31665" checksum="1097AF75CC64CB25" modified="2010-05-18" version="1">MAEFGMKQVETALSNQAKKEASEINDSPTTHLSRLVGLFHSEGPSPEIPDKRYIASDCLDHFMAGKPPRKYAYKFLDRPFKQYLNMASYIGTRTTNDLLGAVLWRLSLPENEATQEKLRQELHEAGIKPGEHPDLSTLQKLPYLNCILKETLRTNPPIPIQLPRVVKDDEALTVMGFKIEPGTNIASQSYTLHQDPNPYPDPEKWKPERWEISPKSDEYRQMQRSFWPFGSGARMCTGMNVSLDDVWLDGDGILLPPEKRKDLYPSLPNQPLRFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ5</accession>
    <name>D4DLJ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_08069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017903.1">
        <property type="nucleotide sequence ID" value="XM_003017857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLJ5"/>
    <dbReference type="GeneID" id="9579781"/>
    <dbReference type="KEGG" id="tve:TRV_08069"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="514"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="869" mass="99079" checksum="11FCA6785A9CDF87" modified="2010-05-18" version="1">MPTPSSGGNRKQMGKRKHKDSSRDESQEEQEQKQRTIPDLFSRDYHSTNHKQAPPPPQSNKRLRRNECDPGRETSSEELAPITVDKMYKFTSSDGKGSNGSAFGFARADNRAPLARTRPFNSSNPSSFTPHTGAKTLKVKNLRDTPKLDQQLYFEKVWSQLDSALTAIFNHEKLPFSLEELYRGVEHVCRQGRAPNLAKNLKDRCMEHISGTVMESLLAKSTSGDEAGILRAVEAAWTQWNARLVTVRSIFYYLDQSFLLHSPNNPVIYEMGLLQFRSSVFSDETLKSKVFKGACLLIELDRLEDSYADPTLLRSSIKLFHDLKIYTSQFEPSMLENSAAYYRNWAATHVAEDDLASYVEKSYRLIEREMARCDLLSFDRGTKQKLAELLDHNLMANQKQFLLQEADIISLLQANNATALERLFSMLERKGMGVDVKSAFSKYIVQQGSSIVFDEAREAEMVTRLLAFKQSLDHIWRFSFHNHEQLGHTLRESFETFINQHKKTDSNWGTDNPKPGEMIAKHVDLLLKGGVRALQNRPVEDITGNSSLTDEDAEINKQLDQVLDLFRFVHGKAVFEAFYKNDLARRLLMGRSASDEAEKSMLSRLKSECGSNFTHNLETMFKDMDLARDEMASYNALLREKNERSKIDLNVNVISATAWPSYPDVPVNIPDSISQAISNFEEFYNNKYSGRRLHWKHTLAHCQLKARFPLGDKELVVSSFQAIVLLLFNDLAGSETLSYDVIKKASGLSDVELKRTLQSLACAKYRVLLKKPKGKEVNEGDVFAYNAKFEDQKMRIKINQIQLKETKQENKTTHERVAADRHFETQAAIVRIMKSRKTITHSDLVAEVIKATKNRGQLELGDIKKNIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLT0</accession>
    <name>D4DLT0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_08154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000519">
        <property type="protein sequence ID" value="EFE37192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017837.1">
        <property type="nucleotide sequence ID" value="XM_003017791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLT0"/>
    <dbReference type="GeneID" id="9583732"/>
    <dbReference type="KEGG" id="tve:TRV_08154"/>
    <dbReference type="HOGENOM" id="CLU_009437_2_0_1"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="403"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="771" mass="88548" checksum="B1D76926FE52BC6C" modified="2010-05-18" version="1">MPAQISHRNDLSSVLNQIVLSSSDTDYLDQLIPSIREYSHGNRTTQLLHSLTKFADDREAKIESICNSTHQDFVSSVNQLLQVREGTVNLTQEILGLNQSILASTKRLAEQKKALVESRSHRQNIDETSKALQDCLEVLRLANQVHELLAKKNHYAALRALDELQNVYLKGVTQYKIAEVIQRSVPMTQKAIADAVMDDLNTWLYRIREMSQYLGELSLFHTDKRKERLAERSEKIPYLSRFKLNLAIELVSDEMEEFDLLYNDDLQVDFSPLLECMHIHQSLGQMDKFQVEYATTRRQQKDLLLPTSITLLSEDGSSLHTLLEEIAGFALVERATMKRVPELRSPVDVEELWDSMSQTAVGLISKALPTVDNSEDILKIKNLITLFMQTMSFVFKSFSVGPFDRLLLTLFEKYTELLKRRFSDDFQELLTLYQIVQTDDYMPMPIRSDEEYDKVLNVSWYTPEKPREEQTYPCVLPFSQMYPLCCIDIRNLLNQFYYFSGDNFNHPAVIDETVRSSLDELLCNKVCEMLTERLGSQYLGQIVQILINLEHFEIACQELEVLLAAARSSNSGEGPIALNATEKFRMNKKAAEKRIFEVVNSKIDDLIETAEYDWNAPKLQMEPSNYMQTLTRFLSNIMNSTLLGLPTEIKELIYFDALSHVANRVIVCGLLFPTRRRLYLSNTSITQALPLDPEVKIINPNGVAALARDADYLSKFVDSLEVPILRENLDELQQTVQLMMAENTDEYYDIAVRNKKYGRVDPMNGPVLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ80</accession>
    <name>D4CZ80_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025703.1">
        <property type="nucleotide sequence ID" value="XM_003025657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ80"/>
    <dbReference type="GeneID" id="9581946"/>
    <dbReference type="KEGG" id="tve:TRV_00117"/>
    <dbReference type="HOGENOM" id="CLU_026885_0_0_1"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="37817" checksum="BDCF624738799985" modified="2010-05-18" version="1">MPSFRGANVNGFEATPESRKPDPSRLVDAYFHSAATLNYIRAALASGLADLHSPLDWGLGHVKTPAIKEKYEKITSRVTDSLRFMRTVGLDTAHGIETADIYTSHEGLILEYEETLTRASRNPVEPAGSRSLPQAVQEEKEFYYDLSGHFLWIGDRTRQLDGGHVEFFRGISNPIGIKVGPSMQPDELVALLDIVNPDKELGKVTLISRYGGSKIADHLPGHIKAVQASGHIPIWQCDPMHGNTRSTPSGVKTRNFSDILSELRQALEIHRAHNSYLGGMHLELTGEAVTECVGGAAGLTEDGLSERYTTFCDPRLNEKQALELAFLVAGFYRDHAAANGTESPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZN3</accession>
    <name>D4CZN3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025513.1">
        <property type="nucleotide sequence ID" value="XM_003025467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZN3"/>
    <dbReference type="GeneID" id="9581750"/>
    <dbReference type="KEGG" id="tve:TRV_00275"/>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="912"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119242" checksum="82EBAE7B12F07230" modified="2010-05-18" version="1">MTVNHHRHTPYLQHAQVSYKTGILAHPSNSILRSIIRIGLPSITTPREERSSRDEGILKLVLYLFRNVVILGATPNLAVEGDEDEASRSMTINAFHDQDVFALILTLCSNIGEEFTFQDVILLEILFHLVKGVDVRQIFMDDNQRSATRKDELKGLMAAESNLNRDRLKNAPTRHGRFGTMIWVKRDAAKVSSVSGQDVLLNDQAAFDKMDKTKKWNKPRGRRPVIDETSNNFNVQVHLTSSALNYLRLFVEEFLDSGFNPLMTSIRKAMERESDRLSESSSRHFFFVSSWFLSAERARREQQEKARRNATGSARDIDPDSFALVASVLNQETFIALNRYMQASLDNKEWQDLSAGMLSFTQTLLTVQEMSKSSLEEDQEIAENILSRIFYEESTHDRILSTLRGYKGQGFWYLDACTELAHVFLRMLEQYSKQNVDMQVRSKRISRRKKKAQNKAQGNQEDQEGEFDNSEDEEEKDRAEAVRNVAERSFDFKRFCNKFCTQNSVNTFVALTSYYRDLNTEQLKRAHRFFYRVAFKQELSVLLFRLDIIALFTRMIKGPEGLLSSSPAFGEWEELVRQILKKMFKKIDERPELITELLFSKIPATVHYLEYGQEKQTVSVASRPAAELEVKQNYTRTADEKIRIVVSVLVADNCEELVRWLCEVLDNALKDRKSWDLADLARGIQDAADIADIAPSTPTIEVSAPDEKRKTALFKNGRLRLLFTLAGLELVGEDVLGTPWSIPGSIPSTELEETRNSIQKHCDDPATEIDGVDPHKLILRKRIAAKSMNDEATTQVNFGNDSEGEDLGLDEILFPPNPRSKSKALKELKQKRRKKTDADEDNQLDEETLNARRLAREQNALERQRKIKSSLFVNASDDETDDEADQEFFAREAERRKRQAQLVEEAMNIDGLGSTVLGDGTKKATSGKRKQAISSESDGEDIGTSQRKRARSEDLGSGNEEEDELGAPPRRKVQTPPTSTEDDLILDVGEKASAPDFQWASTAVDRPSKPTATNKQNIDDDDEDDEPVTTTRPRRPKMMAGFVVDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZW4</accession>
    <name>D4CZW4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025488.1">
        <property type="nucleotide sequence ID" value="XM_003025442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZW4"/>
    <dbReference type="GeneID" id="9581725"/>
    <dbReference type="KEGG" id="tve:TRV_00358"/>
    <dbReference type="HOGENOM" id="CLU_031561_1_2_1"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30107" checksum="2C3BA01E830658A2" modified="2010-05-18" version="1">MKSFILASAAILAASLEPFILTTTTGEIFLSILLALSAGCISIEADVFLFNDTLYVGHEESALTKERTLQSLYIEPLMNVLKKTNPKSPFVSGPTRHGVFDTSSGQTLYLWIDVKNDGEKAWPHIVKALQPLRDANYLTKVQNNETFVPGPVTVIGTGGTPLSQVVSAADRDYFYDGPLKDLTGFTSLISPIASTSLMEVVGDIKSDSENPLNPTQLEAVRKQIKAAKDKSIGVRYWETPGWPIRLRNELWRTLWKEGVALLNADDVNAAKGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY3</accession>
    <name>D4CZY3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025437.1">
        <property type="nucleotide sequence ID" value="XM_003025391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY3"/>
    <dbReference type="GeneID" id="9581663"/>
    <dbReference type="KEGG" id="tve:TRV_00377"/>
    <dbReference type="HOGENOM" id="CLU_007948_1_0_1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="216"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="360" mass="38151" checksum="A89A3BA25ADEE92F" modified="2010-05-18" version="1">MNWDVLCFNAAALIAGVFVLDYGADKFIDHTVIVGQRLGVSQTVIALLTAGAEWEELAVVVAAVLQHRSPLALGNVTGSAISNILGAFSLGLLFYPQGLEFDRSAKVYSALLLAVTTLFTVLAFFNLLNRLVGGILIAIFGLYIASIIYAIYKGVASPPELSDSDSDGESSDGDDHGPLSETAPLIENNEHEHEHEHAPSSNDKGSKRNRGLPYHIFHLIMGFLSLSLSGYILSHSAVTIADSLHLSGTVFGLTVVSFATTLPEKLVAVLSGSRGQAGIMAATTAGSNIFLLTLCLGVVAAAGYQAQGVDNFVLFELLAVWVSSLAFCAVVSLGLGRNSGILLLAAYIVFLCLEFTIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D007</accession>
    <name>D4D007_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_00401</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025461.1">
        <property type="nucleotide sequence ID" value="XM_003025415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D007"/>
    <dbReference type="GeneID" id="9581697"/>
    <dbReference type="KEGG" id="tve:TRV_00401"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE44850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="51458" checksum="A9C14A0645626F5D" modified="2010-05-18" version="1">MADKGLEEIPDGQIESNYDEVTDSFDAMNLNSELLRGVYAYGFERPSAIQQRAIMPVIKGSDVIAQAQSGTGKTATFSISALQKVDTNLKACQALILAPTRELAQQIQKVVVAIGDFMNVDCHACIGGTNVREDMKALQDGPQVVVGTPGRVHDMIQRRVLKTDHIKMFVLDEADEMLSRGFTEQIYDIFQFLPQSTQVVLLSATMPPDVLEVTTKFMRDPVRILVKKAELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLQARDFTVSAMHGDMEQAQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVAGKLFPSNSMRRRQRKKTNNYLSRSYLITSLFFTFGIPTPFQNSFFLSSLESIMPFPYGISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D034</accession>
    <name>D4D034_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MIND kinetochore complex component Mtw1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025367.1">
        <property type="nucleotide sequence ID" value="XM_003025321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D034"/>
    <dbReference type="GeneID" id="9581602"/>
    <dbReference type="KEGG" id="tve:TRV_00428"/>
    <dbReference type="HOGENOM" id="CLU_046437_1_0_1"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35758" checksum="47C67465E76E14BD" modified="2010-05-18" version="1">MNDASTALLTEHFSYTPLSLIDDVINSVNNLIYQAISSLEDGLQSTPPEKLGFRHGPGTIPDTDDDGNIQYPEARLEIENGLHQLETLLEATVDKAFDKFEIYVLRNVLTVPEDLTGWIRLSHHEGLSLEPAREGAPTEESLTLQRQRLRETKKLNRMLTHECARNDAVLSQLRSMVATVKQNHDGATVSVGANGSADMQLPNLSFLLSDPRAKKLRMGDGGAGPSHTPLTTNTTFILSQLPALRAVLTQLRTKLQTLPKSVGEMDLDQKKGERREYINSRAKLHLERTSGTGESEHGHGVIRGKRINPEEVQALEGVATTFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0E3</accession>
    <name>D4D0E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper fist DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000029">
        <property type="protein sequence ID" value="EFE44688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025299.1">
        <property type="nucleotide sequence ID" value="XM_003025253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0E3"/>
    <dbReference type="GeneID" id="9582910"/>
    <dbReference type="KEGG" id="tve:TRV_00538"/>
    <dbReference type="HOGENOM" id="CLU_022327_0_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="587" mass="63115" checksum="2C625D57C82CF8E2" modified="2010-05-18" version="1">MCLSTSPAASLRLHRRPRCLAVSLPLLLPLPLLYLSSSLLSSPLLSLLFLSVCLSCERYYGPLLPDFVITAVSLSVCLWDPPSPPALPPVSPPPSSSSSSYSTAVSCKPSFSSLLLLLLLSSSRTPEQQFNSVAMLIDGEKWACDACIRGHRVSTCNHSDRPLSHINKKGRPVSQCPHCRGLRKARTSHAKCECGEKPHSKADCPLNGTAADGQKTAGGRKHCCCGHGGRCTCASKRDSNLETVPETGPVAAARRSTVSGVKRPHITTSKKQKEASKRVHPYPLPRSRTIHGTADLAHLSMDHLNEGYGSQGVSAYPDLVTSAPRPVRRVKSENGSPVAEVSDMKAQLSLDIPYQHFPDQMGLSMPILDYPQQSPGLYYPSDIDFGFEAAISNGPSIDWSTFDLPYGSDAYTATYSQPASYASYDYNTTTFGHPGLARSSSGDTSDADELLPIVGTGSEAGMYHLGSTPPSQLDLPSQFAMSQTYKPAAIEPVLHAANDGVDVNNHHQQQTQAYPASGSHSSFVDASNAPMIIPPAAYTSAGANEPLWVSASYPGTMMSPVSISVPEQQQQQQQQQQQQQQAQIWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0T1</accession>
    <name>D4D0T1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="1">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025151.1">
        <property type="nucleotide sequence ID" value="XM_003025105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0T1"/>
    <dbReference type="GeneID" id="9580644"/>
    <dbReference type="KEGG" id="tve:TRV_00676"/>
    <dbReference type="HOGENOM" id="CLU_343609_0_0_1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="349"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="824" mass="94382" checksum="01D6DCD86DC865B7" modified="2010-05-18" version="1">MASKVTFTLNSGYKIPAVGLGTWQSKPHEVEKAVEVALKAGYRHIDGAFAYKNETEVGLGLKNSGVPRGEVFLTSKLWNTHHRPEFVEAACDKTLRDLGVDYLDLYLMHWPVAFVPGEAAFPKDTETGQLLLDNKVTIKDTWRAMESLVKKGKSNKDESAEIPPAVNQVEAHPYFQQDDLKKYLCEKNILLEAYSPLGNNLHNMPRAMDDEKIQKIAEAHGVSSARVLIAWHVQRGTVVLPKSVTPERIIDNFKDFELSQSAMEEINALDRNARASQPLFWGVDIFGEKGEEYVKEIAKKRGLEYIASLKYNEAKRLSERHLHFNLHVLLNIIAKSVARPEDDITEFSKIGEGGSYRVFEAKFEDGLAVIARLPYPCTIPPTYGIASEVATIEYLRLQGIPIPKVLDWSSSPAINPLGAEYVIMEKARGKELEATWYSMNFDERKSAMEKIVAIESLLFNLKLPSFGSLYFTDSLQHGTDVVVLPDNNTFCVGPSTEFLWWYHKRGELKTNKGPWKLPAELLNSIGLRELEWLRAFGAPRYPREPLYRRLYGNEKVNPEVQIRNLEDFLSVAPHIIPSQEFLNEPTIRHPDFSPNNIFIDDAGEISGIIDWEHTSILPLFVQAKIPRYFENYGDEDSENFKFPALREDFNSLPDDEKELEQEMYRRRQTHYYYLGFTSRYNLNHFRTMGSYSGMMRSRLYDVVNRPWEGDNTTLKATLIQMSSYWPGIAAANMKDTQYPLKYTPEEVKQCLNLDAEQKTANTQMQNLRDAIGINVDGWVPSEMYEEAAERMAHVKAHMLEIAETEQDREDILQKWPFQDHEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0T4</accession>
    <name>D4D0T4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025154.1">
        <property type="nucleotide sequence ID" value="XM_003025108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0T4"/>
    <dbReference type="GeneID" id="9580647"/>
    <dbReference type="KEGG" id="tve:TRV_00680"/>
    <dbReference type="HOGENOM" id="CLU_1626616_0_0_1"/>
    <dbReference type="OrthoDB" id="4171942at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055491" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19255" checksum="87C3252684E1A618" modified="2010-05-18" version="1">MIFISTVLFLLLACRPATAINVTYYIEQPLNTSFTVYDDFNGHILGLGVGGDGLLEVQPNSTTRWHFEQIFDFNYIIRESNSNRYIHVPDPKLGSLATVSETAATVIDPTVYDNAQYKFYIRHEGPGLFFTVERHSTEQPNRYVIKLRENTDGKRQNFTFIKPPKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0U7</accession>
    <name>D4D0U7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000043">
        <property type="protein sequence ID" value="EFE44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025139.1">
        <property type="nucleotide sequence ID" value="XM_003025093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0U7"/>
    <dbReference type="GeneID" id="9580631"/>
    <dbReference type="KEGG" id="tve:TRV_00693"/>
    <dbReference type="HOGENOM" id="CLU_162793_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="96" mass="11622" checksum="2EB1C58EB5B57531" modified="2010-05-18" version="1" fragment="single">KRSLKKKRKKQKRKKTTTTNKQTKRQREKKDEDDDNNNDEEAKTKRQEEEEEEEEGHPAVVYERPLWHRQLRLVDLRALVLATAARRCQRSQQLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D145</accession>
    <name>D4D145_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024988.1">
        <property type="nucleotide sequence ID" value="XM_003024942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D145"/>
    <dbReference type="GeneID" id="9580531"/>
    <dbReference type="KEGG" id="tve:TRV_00792"/>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="189"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="416" mass="47298" checksum="2A5EF98382C9D98A" modified="2010-05-18" version="1" fragment="single">PQVHHQQPQPQHPQQSQQPQSHVNPREHARLLARERQYAIADQMSRMATDEYQEDILAHMHAMDTATQPDVDSIDIQTEIQWFMRPYLLDFLIEAHAAFQLLPATLFLTVNLLDRYCSKRVVYKRHYQLVGCAALLIAAKYGDKKDRVPTIKELKSMCCSLYDDDMFIQMEWHVLQTLGWSIGHPTVDSFLQNAVVDTPYDPEVEHLALYIAEISLFHRDFVSKLSSDIARASLALSRCILNRPQAPQSDWASNYDSLTLVSLSQYLQKPSHVLTRKYSSAHYSRASKLLEQFLARQESLNKSYNPPTPPNDRMCESKAPYENEAGLATPQKTQYPAVSHGYITPPITPENDAFGVPGNPNVAKDGSTMLYNCPPSPTPAPTMQYTAQHYEMTDASAYSHHRLFPQPPAQTFNPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1W9</accession>
    <name>D4D1W9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024789.1">
        <property type="nucleotide sequence ID" value="XM_003024743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580279"/>
    <dbReference type="KEGG" id="tve:TRV_01071"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="34"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="912"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2297"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="912"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2377"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2807" mass="311555" checksum="9DB798D113F879DB" modified="2010-05-18" version="1">MGSIAVEELLKERESSASTSCTPMKAVSNSQDVPPPIAIVGMGMRLPGGITSAEEFWDFLVSKGDARSKIPESRFNIDAFYNSSKPGSVRTEYGYFLNQDLAHIDTSFFSMVKYEAERLDPQQRLLLEVVWECLESAGVTGWRGKDIGCFVGSFGEDWLDMSSKDTQDINRVRAIGAGDFALANRVSYEYDLKGPSITFRTACSAAMVALHNACLSLSSGECSAAIVAGTNLALAPTMATTMSDNLVLSPSGICRSFDADADGYGRGEAINAVYIKRLEDAVRDGDPIRAVIRSTATNCDGRTPNISMPGAETQASLIHQAYSQAKISDLSATAFIECHGTGTVMGDVAELTAVAKAFGEKGIYIGSVKPNVGHSEGASGLTSIIKATLALENKIIPPNINFKTPNPKEPTTWPHDRSERVSINCFGIGGTNVHVIIDSAASFTAMNSEYLERPAPQNKSRLLVLSANSQNSLQRQVENLKAYVESRPEVSNDLCFNLGARREHLKYRAFTILEQEGSIDTAGFETSQYTKSRSMVFVFTGQGAQWVGMGKELLLEFDIFRNDIKAMDTALQKLKNAPCWSIEDELLKSSEDSRVNEPEYAQPLCTAVQIALSNLLELWGLFPTGVIGHSSGEIAAAYSAGAITLESAIIISYYRGQVTKSISENDATPQGGMAAVGLSPEKVKRYLIDGVVIACENSPQSVTISGDSDKLDKVIAKIQSTEDDIFCRRLRVGVAYHSHHMQGLTGLYQDLIGPHISFKDAMIPFYSSVTGNIIIEPIQLDAKYWAEILSFTVLFSTAVGSYLEKNGGNALFLEIGPHSALSGPLRQIFDGHQAKLNVTYIPTLIRGEGQRKSLLTAAGRAYMNGSPISFSEINGPGRVLTDLPKYPWQHDVRYWGENLISQRWRSRQHPHHEILGSRVYETSDIEPTWRNLLYVEHTPWIWEHRLNKEIVFPCAGYIAMIGEAIYQITGSHAYSIRNLFMKRALILEDSSVLELVTSLRPVRLTDSADSKWYEFTISSCNDNTWQKHCTGRVIPGDIEVCRFKEHKGPFIRQVQADQWYSALANRGLHYGPRFRGLENITADPIDYQATASIADDENLHESHYSLHPSTIDQCLQLFSVAFTHGISRQMTKLSIPVSIEKLYISTGALSMAAHAKGTGRSSSTASGRVVMTLDNKTVLWMEGAQFFTVDEEDTSLPRRRLISRCVWKPIVLLCSIAKLSGSASRPSSVHSRRIVGQFTNLLILECFHRIKHLKADSPHLVKYQGWIISQTDRLSKGLDELFPETSSWAAASSEARLTAMESLVRELEVESPRDMPLIDISKTLLDHCPQIIEGKVSPLEVLMEDDRIKNVYNNLCWTSGWSDFFGLFSHWNPNLRVLEIGGGVGSATATMLLHLAPAGRTRMYSKYTFTDISPGVLPLAKERFKDFEEIEYSVLDISKDPTKQGYSPESFDLIIASNSTYACYWFLEVALYWRNFAQGVLPGWWLGGGDGREDTPLVSPERWGRELQKNGFSGAEAVFYDCEQPYHYGAGIWSRRADIVPVKGDIYLLHHPTVHEWAYIAEAQLSQRGYTVHWCTLDQLPAGKIIISLLDLGGPFFDKISEGNFRAFQKAMSTATNCRMIWVTRGSQLECSDPRYGLVLGLARTLRFEMDVDFSTFEVDKFDEKTATSLCDLLKEMQIFREKPWLDQDYEFAVRDGVIHIGRFHWTPLDEEITTTNKPNMSKGLHIGTYGLLDSLSWVEYEEPPVGGNDVMVEIKYTGLNFRDIMVTLGALGDTSEIGLESSGTIFKVGSNVKNLRVGQRILALGIGLLRTRKVIPANHCVPIPDGLSLEDAATMTSVYATVILSLIRLGNLQKNQIYATVGNEQKRKYLVENHQIPEDHIFDSRSASFFDGVMRHTNGRGVDLVLNSLSGELLHASWRCVAEFGRMIELGKRDIMGHAQLSMDGFSGNRAYFGVDLFRLGETDATMFGHAFRYMQTGKHMGKIIIKMPEDPAELPVAKNNLNLSLSPGGSYLLAGGLGGLGRPITTWMIEKGARNFIFLSRSAGESDSDKAFLRELDAQGCTATVVKGNVTELDDVKRAATASPKPVVGVINLAMVLRDEAFEKMTYDDWNAALAPKVQGTWNLHNVFKDVSLDFFILTSSISGMRGNFGQANYNAANTFLDTFVRYRKSMDLPVWAIDVGAMQEIGHFSQDKNLVKKALANSIEMPDNSYLVDALQVAMLKSKESESGQFAIGLGTSKPPPDSGNHPLWPRDARFTINKNLQWKSDKANTTSIVDLRSFVEDIKKDPSILDSPESKKRIAKELRVLIGPRAGLDENADDEEIDNIVIDSLMSIEIRSWFRRNLSLDVPLIEISNAKTVGGLTATTMNALRCKYQSKSTEDDGKDSGISTSETPDEGTLKNDILLGTGLQPTPGPTIDWKCESEGRIFLTGATGFIGAWMLASLLGRPDVKIVACLVRARDENTGLQRIKETFKKYGIEWKCDEKLAVIPGDISKPKLGLEGAKFDELSAWTSAVFHFAALSNFLEPYSAHREANVIGTFNMLQFATNKRRITFHHSSSLSACGLNAYLGKQHISEDQKPEVDLKKAGHHIGYSYSKYTAEMVLWNAISNGVPASIYRFSMVLGHSVTGIGNDDDATSRMMSNCIQIGSYPIAPKQRSQFVPVDFAVSCMLEISTSLENIGHAYNVIQPDQEKLVDLPATFDMLRQCCPSPLRPVPYEDWLQSLAKFRAGRMSVFLPEMEDKEHERRDIWQNIHAGEHRYGTDNLRRALAHRPEMLQLPSMDKLMKVWSAQWIKQATRREQTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B7</accession>
    <name>D4D2B7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromatin remodeling complex subunit (Rsc9), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024604.1">
        <property type="nucleotide sequence ID" value="XM_003024558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B7"/>
    <dbReference type="GeneID" id="9579928"/>
    <dbReference type="KEGG" id="tve:TRV_01220"/>
    <dbReference type="HOGENOM" id="CLU_008152_0_0_1"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="111"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="646"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="924" mass="105158" checksum="3156A4722C97C49E" modified="2010-05-18" version="1">MNKSHISLQDIMSLDLIGNFERSSQAMGFSTLHYHEVAAISSLPKPLETLFNLFLFLIKLPFPPLLFSRRRKKKKKDSPRKDGRSHQPNPSKLQSRERQMERKKTATELVCEDEQRFWASLRHFYGQGNESWEARPGTRWPAGSKKINVYTLFVQIVTRGGFDEASKDKKNWWEAGHIAGVPPGLVGTLSYQVKQLYAERLLDFEYYLLLIPPSEIPSESQAYPLLSPFSSLSSSGRYIPSLFSPCFSLSASVVTPKMDVIEHDTPSNRRGVFATSSSRLPLPPDIDPLMTLALPDQGMPSFCLLAGPDSNAETVPNIYRFCWMGIRSDIDKEVDFALHHLIVISDERGDKLKFSDFNMLAESLAKQVLKVSLLVYGQEWVIELDHPNNISSKNLNVIFALTGTPDLLHRIQSKKVCLDDTNLEDESFRIKLQRVNQAALIIRNMCLLEENARWFAEEPLLRDCATIVLNLPCQDRFIELKNYFLEIIEQTCPFWDIWDQDPLYQTLINLISSEDRFQLLTALKCLSLFAIERIESKIIDRIPSQTIEQVIRLTLLKQDPELLSVALDFLYQFSRYQLNVQQLVADFNLPVDLIPHLVHLLDYGSVVRNKEIIDQAERKAPPPNQIPIPHQDLYRDLVKHSEPERCSLWLKCCFVEDPECEITQLAIWQAYQACFSQNRIPGVQSADTLQATEFISTVSNTFSSAQAKVVEGPSARFIIRGIRPLETTYNLDGFLSLHCLWGKQGEIRCDHVFVDPAILRNHVFQDHLQLSPLASGGWNLQPQPSNPRACHWDYCSEYLAPTPNIALIAGHVSAHLPPLRDMTKPPPIPPRAIIQPKCARLFKLYPTPVDEHGEPYGIAYKALLVMRYILIGLPSTPSGSQYNNLPWRKVVFGSQRSHLIEAATENPSLTKEIFAFLNELDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2T2</accession>
    <name>D4D2T2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024425.1">
        <property type="nucleotide sequence ID" value="XM_003024379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2T2"/>
    <dbReference type="GeneID" id="9579647"/>
    <dbReference type="KEGG" id="tve:TRV_01388"/>
    <dbReference type="HOGENOM" id="CLU_189355_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="70" mass="7714" checksum="8B913627C3922787" modified="2010-05-18" version="1">MFTLLEDEDEEEDEEREDEDVDARELLRRSHSASISSSRTSSSDTWWLSASSSSTNRDVNGIAGSASGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D305</accession>
    <name>D4D305_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024395.1">
        <property type="nucleotide sequence ID" value="XM_003024349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D305"/>
    <dbReference type="GeneID" id="9579617"/>
    <dbReference type="KEGG" id="tve:TRV_01462"/>
    <dbReference type="HOGENOM" id="CLU_005446_1_0_1"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117770" checksum="D8002DDF3A217D5A" modified="2010-05-18" version="1">MSAPPTKLNPHDVISSYFIGPKAENLDSFRINIKTILDELRDSRHQYFENDEVFITEDVTKSEQYQQIVLNFNKAVQKASQILGKRSVPFWSPRYEGHMCTDLTTPGLLGYFMTMIYNPNNVAVEASPLTTLIELEVGKQLAEMFGYNIDEKKRASPFPRNLKFYPLTLSWAMKEGSLWFIADKFKVTPCVGNEKLFKDLTPWELLNLSSHTILGLADRLHEQFGITSKYLEGALNPFSIQTVGKDRLEAYFGINKPMKYFHAKTRHYSWPKGGAIAGLGSGNMHGIKLDLDGHISLEDLEIELNRCLREQQAVFAVVAIMGSTEEGAADPLRAILDMRADFQRRGLSFLVHADAAWGGYFSTMIPKDAKAPQMPGSGSGAGGKEVIEIVPSLPLKESTLTNMIALKDADSITVDPHKAGYIPYPAGSLVYRDGRMRFLVTWTSPYLSQGSSENIGVYGVEGSKPGAAAMATWFSNTTIGLDRNGYGRLLGEAAFTSARLSAHYAAMHYEEETDPVKKKKHYICIPFNRLPMEHAGYGSLSPEVNARRKHIQENILEKTNEELMKSKDDMKYLRELGSDLNINAFALNWYREDGTLNDDLEEANYFMKRIVHRLSITSSAGNPREIPLYLTSTQFSEELYGECAQNFMKRLHLAPAAEDLFVLRNVVMSPFPTHKKFICSLMEVFEKVIEEEVKNVWERNKRGKYQGVFLMRGTDEIFLDYHTSFHQATRRQQIILAAKLDGNEMKEYVELKKNQSGEIAFQSEDPFDLEGFVEEVKNGKNPTLKGILGVRQKDKIMKSIDCTIKATRIIKSRPLNSANRDHSYPQHNMPFYLYGTKEQHHISHVLLKAPNICLSASNVKLDTELAKVVHDNICQGLVLTLCDYREVTMQPCPDKNEVIKKDAHFFFRPGKEFEVKVFRDPNAPIAFGPGLLANLDTPIARGKMTLDQDCHVDVESLNNDPLDKQTLPYNPLNDLKELEKVLTIATAEENPQPDAPRIAQLSATAVTQFTAAETSADSTNTANVSGTPGTPGTPESDESSTFSIPRPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J5</accession>
    <name>D4D3J5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS maltose permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024156.1">
        <property type="nucleotide sequence ID" value="XM_003024110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J5"/>
    <dbReference type="GeneID" id="9579194"/>
    <dbReference type="KEGG" id="tve:TRV_01655"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="559" mass="62314" checksum="D38E3BF15D44217D" modified="2010-05-18" version="1">MASEKKDIDASNVGSTRLSVGESDGENAPIADIFQNAKAATDKERKMTLLQGIRLYPKALAWSILISTCIVMEGYDISLISNFYAFRQFNQKFGVRLEDGTYQVPAPWQAGLSNGAAVGEIFGLFLNGWVSERFGYRWTILGSLAWLAAFISLFFTAQNVQTLLAGEILCGIPWGVFQTLTITYASEVCPVALRGYLTTYVNLCWGLGQLIGIGVIRSMLDREDEWSFRIPYALQWMWPLPLAIAIYMAPESPWWLVRKGRIADAKRSLLRLTSRSDESDFNADETIAMMLHTTALEAKITRGATYWDCFKGTDLRRTEIVCMVWAMQNLSGNSFSNYSTYFLEQAGLSSSHAYSFAMGQYAINMVGVFGAWGLMSFGIGRRTLYLAGLCGLCAMLMVMGFLGLVPQSHRDAGSLATGSMMIVWALFYQLSVGTVTYSIVSELSTRRLQIKTIVLGRNLYNIVAIICNVLTPFMLNPSAWNWGNYAGFFWGGICFCCIVYSYFRLPEPQGRSFAELDVLFERGISARKFASTEVDVFSEEVATNVIDTYKEKDSGNVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3K7</accession>
    <name>D4D3K7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024168.1">
        <property type="nucleotide sequence ID" value="XM_003024122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3K7"/>
    <dbReference type="GeneID" id="9579206"/>
    <dbReference type="KEGG" id="tve:TRV_01667"/>
    <dbReference type="HOGENOM" id="CLU_499854_0_0_1"/>
    <dbReference type="OrthoDB" id="5397734at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="202"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="58119" checksum="7927A29BEF9B52BF" modified="2010-05-18" version="1">MKTFLCVMVRCYTPDWEKFTDLFNIVFANNLKACGFHEGTRIQPLRSQWNHLKHWKDPIWTCVNLTPLAQWAGLSLFVEMIERTAHGKIRLFAQRGVDIPHLLAMGKEARSERISSSSTTPTQTRIQQTSPELPIQITSPVRSQLPPTPVSDSHVLPSPAREYLPSETPTPTQSPSQSAHYNSTPPSSLQSPLQSVRPDVTPPPLLFRFWDENSGGINSANKFVAGMWDQNATTPIPDHSTIHPRIISTLVRMHLTRVNVSSAFISLSTSPLGVFHRALRAGKANISILDTSKMNQSHLFSVIPFLRHEPIMYGSEGKSRYFGQGEWLVWGIIPSEAILTTFSTDTLFSISTEYPSVGKLLQLHLIKNAKFNRAPLIRKLGSKNIMADMHSGRSVGQFLKLLNVPQPHISTLAMLFATKWSWRSPGDKRAAYLQGVQRGFISAYSLKLPPPDAENTESEQEEDATGQYYEELESDREDESTEVDCQNEIQNAAGDDIDLASGVADPFAMKRASIAAMLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3V4</accession>
    <name>D4D3V4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TRV_01766</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cell tip</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024097.1">
        <property type="nucleotide sequence ID" value="XM_003024051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577085"/>
    <dbReference type="KEGG" id="tve:TRV_01766"/>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 20" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 20" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1593"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1621"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1648"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="24">
        <location>
            <begin position="1"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="951"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="25">
        <location>
            <begin position="1792"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="583"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EFE43479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1850" mass="205616" checksum="CA6FD93770068D8D" modified="2010-05-18" version="1">MATPTHAQSSLPALPAHLQNDTHLAAHLASRFHVSLPTARLSSQALICLNTYTSSTKGPDGGKEGSAMGEAEDLARRAWTRLGSRGENQAIVFLGESGSGKTTIRSHLLSSILSFSSTPLSTKLSLAAFVFDTLTTTKSVTTPTASKAGLYFELQYDGSSTVNPTLIGGKVLDHRLERSRIASVPTGERSFHVLYYLLAGTSAAERSHLGLESPTTVRGGAGNRTSTSEMHKRWRYLGHPTQMKVGINDSEGFQHFKTALRKLEFPRSDIAEICQILACILHLGQLEFATGQSTRTAPEESGGYSHEGGETVTIVKNKDTLAIVAAFLGLSTDDLELSLGNKTKTIHRERVTVMLDPAGARANADEFARTLYALLVAYVIENINQRVCAAESAVANTISIVDFPGFAQTSATGSTLDQLLNNAATESLYQYCLQNFFERQANMLETEEVSVPATSYFDNSDAVRGLLKHGNGLLSILDDQTKRGRTDMQMLESMRKRFDNKNPAISVSSSTAILPGSNFPTQNTAASFTIRHFAGEVEYPVKGLIEENGDLISGDLLNLINNTRSGFVRDLFGQEALQTIHHPKERSAIMQAQVSSKPLRMPSMARRKTSRVSKFAPNAPNSENDDTDDASSGRRGASGNHNKKTGDVGLKQGAAAQFLASLDNINKSLSATNVNPYIVFCLKPNDRRIANQFDSKCVRTQVQMFGIAEISQRLRNADFSVFLPFAEFLGLAEEESVIVGSDKEKSQLVIDEKRWPNNEARVGSTGVFLSERCWAEVAKVGERVVPAFNGSGTDDGSGMGNNGYGDSKVRLLTPADSTPGAYIYGDETKGGYFNSRDVDARSDAGASAFHSGDMFKNLETREQMAEKGNEKKMVEVEDVIVSGSRKRWLFLVYLLTWFIPDFLIKLVGRMKRKDIRIAWREKLAINMLIWFTCGFAIFFVIFFPGLICPPQHVYSAAELTTHNGDPGKDAFIAIRGEVFDLGEYAKSHYPSIVPRKDLLKYAGTDASDLFPVQVSALCDGVDGKIDDAVQLDYTPINRTGSASVISKSDTNAQYHDFRAFLEDSRPWWYFKQMKMLRQTYAKGHIGFTQKHLNEMADQSQYIALINNRVYDVTTYITGGRIVKSKEGQATPKDVNVDFMHPDVISLFQRYPGQDITKRFEELNIGSAMRRNMKICLDNLYLAGELDIRTSPRCLFSQYFILAISVLLATIIGFKFLAALQFQKKNIPENIDKFIICQVPAYTEDEESLRRAIDSMARMKYDDKRKLLLVVCDGMIIGQGNDRPTPRIVLDIFGVPENIDPEPLSFESLGEGMRQHNMGKVYSGLYEVQGHIVPFLVVVKVGKPSEVSKPGNRGKRDSQMVVMRFLNRVHYNAPLSPLELEMHHQIRNIIGVNPTFYEFILQVDADTTVAPDSATRMVAAFLHDTRVIALCGETGLNNAKSSMITMIQVYEYYISHNLTKAFESLFGSVTCLPGCFTMYRIRAADTGKPLFVSKEVVDAYGEIRVDTLHMKNLLHLGEDRYLTTLLLKHHSKYKTKFTFNAHAWTIAPDTWAVFMSQRRRWINSTVHNLIELIPLQQLCGFCCFSMRFIVFIDLLSTIIQPVAVAYIVYLIVLVALNSGTVPWTALVLLAAIYGLQGIIFIVRRKWEMVGWMIIYVLAMPVFSMGLPLYAFWHMDDFSWGNTRIVTGEKGRKIVISDEGKFDPASIPKKKWEEYQAELWEAQTHAGADDRSEVSGYSYATKTHYAPATEYGYSASRPVSQIDLSNRYSSRLSMSATELLGRGSDVEMADLSALPNDDSLLAEIRDILRTADLMTVTKKSVKLELERRFNVNLDAKRAYINSATEAVLSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3W8</accession>
    <name>D4D3W8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000094">
        <property type="protein sequence ID" value="EFE43464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024082.1">
        <property type="nucleotide sequence ID" value="XM_003024036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582774"/>
    <dbReference type="KEGG" id="tve:TRV_01781"/>
    <dbReference type="HOGENOM" id="CLU_000022_0_5_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1663" mass="184769" checksum="20D05C12123F21C9" modified="2010-05-18" version="1" fragment="single">MMDVIILSELAKSLQIPKDTINPSSTFYQIGGDSMIALAVSASCRRQGVSVDVPSILRSGSISEILRNAKLLPTQPVNTVPKGDLKPVNNISEAELDRPAGFHHSSTKARQYSPTPTDLRNAVGSSRGNGVGSCSMAKLQSVLVLDTKARPGNNVISYFQEYSPGQIPTLKRAWQKVIQSEPIFRAVFDDDFFLENGMACFVWSENIHRDLCSFEEHVESIKAPEMVEPATEFEIITLAGKRSIVVWHVHHALVDGYSARLLLQKVCTLMEGGQITEGRSFLELSRAWQMYQAIFEGQARQFWQDYLSKVTDNDFLLPPPCNQSSNNSLSANFVAFSVPLQRIIRYSSEMNLPLSSIYYAAWSLVLAIYTGSDTVSFGIVFENRSIPIPGIRETVGPMMNTLPLILHLDRGTAFKDLLLCTTQRVAKLREFEWSTPDQSPKMTSVLAMQYDYEAVLSPTSSTMVSSTRLQSSIPINIFLGPKEKIQINYDKVLFDHSDIEDLVRMYVNAIETLIGPEGTLDWYFRHSLTPELLQQSLLNGNCFSDATLGQGEDTLTSLFDACVKSAPDSVAVARGDESLTYAQLDAAATKIASSLCEIVLPQEVICVHADRSINWIIAIYAVLKAQAVYCPLDPASPDDLRDSYFRTSGSRVYISPFKESKARKPSSCSLFYSIEELLYQADNTPGLVTRYGNSIISKKDLAYLCFTSGSSGLPKGVVCTHEGIVAFQKDYNARLHMRPGLQVAQVMSPAFDGSMHEIFSCLSYGGTLLLSHKADVLGNIQQANVAMITPSIGKMLNPCDHKNLEAIYLVGEQLPQAVCDAWSATVPAYNMYGPTESSCGSSYKRLVHGEIVTIGKPVESTRIYILDQHQNLLPPGVIGELYTAGVQVSPGYIQRPDETAKNFLKDIIRPETGQMMYRTQDRGYWNRSGEICLLGRSDRQIKLRGFRLDLNDLEIRMVANTEATSVAIARKDDILVAMIQPETTNIALFKETIKKVLPPQAIPRLIKAVDTFPLANAGKIDYKAVAAAFCASIPRVSSHGRPVSPVSTPADAREAIATVWRTLLKLEDGHVLDDNSNFIELGGHSIKQITLSKRLSSILDRDITLADVIENIRFGDQVNKFLPAYSESSGSQSPLIESAATTPAVGIRDQISSIWQSLLSLDREYPLNDDSNFIELGGDSVLLLNLASRLTCLGGRHIALHSVIKRPCLGDQISLFSSSKLGSVAEASKPEIDSKPGCLSLSPIEREWVEKYKVGKGSSSFNVNYACALSGDTDIIKLEEIWNKVLKRHEILSSLFPNEHTRSYAKVPPQVAVVGKIDIREEVNREFKLDEEHPIRVFITPTTFLLVASHIVLDLTALNVILRDIEICWGGKILLPLQRTYSQTAQWSRDVSQDDLDFWKSLSEVPCYREPLRLSYNGTSRVCKIPLETFQGMVQFTVKHSITLHQLSLAAVALALYPTGTHDQLAVLGAPYLNRGVEDFDTVGLFLEPLPIRIKVPRINRRDSMQQHISPRETWSHAFAKSVGKASQDALSHAIPWNRLLEYLDIQPQHPNVPFIEAMVTFHDNRGQKASAIPGTQQLYTWCEGSKFKLMFEFSAIGNETLMLRIEYDNMIYNDTKARNFQRRTIAALEAISQGFEQEKLVELIQTAMDRQSSEGSGNEYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4J7</accession>
    <name>D4D4J7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023817.1">
        <property type="nucleotide sequence ID" value="XM_003023771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4J7"/>
    <dbReference type="GeneID" id="9582392"/>
    <dbReference type="KEGG" id="tve:TRV_02014"/>
    <dbReference type="HOGENOM" id="CLU_3052077_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="54" mass="6748" checksum="0C438E4A3E08C768" modified="2010-05-18" version="1">MRAETKNEAKKEKEKEEEEERKGKKEWNEFAIEDILKRCPSKRGRKEKRRKKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q3</accession>
    <name>D4D4Q3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023780.1">
        <property type="nucleotide sequence ID" value="XM_003023734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q3"/>
    <dbReference type="GeneID" id="9582362"/>
    <dbReference type="KEGG" id="tve:TRV_02069"/>
    <dbReference type="HOGENOM" id="CLU_1021426_0_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="29750" checksum="88A036C223CCD2E9" modified="2010-05-18" version="1" fragment="single">APTAIMCCIISIVLLPPAKPMDKNVKKIALRKRVDFLGIAMFAISITTFLVALRLLGDHEASTRITILFGVVSVVFGAFFLVVETYYAREPVIPPGLLKSMAGPYAVQVLLQNLTNIAPYFIRTTGASNTRAAIYLAPVFVGFTTGSVTAGYIIRKYKTLSIISVLLGLTFFILIAVRWRTGVSSWESLYVLPAFLSFGLLLSTTFTGLIACTPKSIHATAICVYYLCQQVGTMLGTVLSSLTIETILREVLKIRLEDIPNKKEVSSLPSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5D7</accession>
    <name>D4D5D7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023560.1">
        <property type="nucleotide sequence ID" value="XM_003023514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5D7"/>
    <dbReference type="GeneID" id="9577032"/>
    <dbReference type="KEGG" id="tve:TRV_02307"/>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="90"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="76101" checksum="A17154A9ABAAB54F" modified="2010-05-18" version="1">MTSIYGIRHSTFKQKQSNRNRGREDEDEDEEKQTKQAVDAHLERSLLSPSTSTAPNIPSFSFSVVIMASWFTSSSPLDDQVEKATSSSLEDIALNLEISDLIRSKTVQPKEAMKVLKRRLETKNPNVQLATLKLTDTCVKNGGRHFLVEIASREFMDNLVSLLKTEGPNALNHDVKTKMLELIQNWAMAAQPRNDLSYIAETYRKLQNDGYNFPPKTEISSTMLDSDACSSKTLPLPHLGIIQPVRVDDGCYAKLTSKSTSAAARSFSNSSNVPAVPANKPRMEPRSAYADNDFDEDLKRALQMSLEDSKGRQSSGYVPQPKSTYASPKVQVSAPKNDEEEDADLKAAIEASLKDVEEQKRKHIAALKSSAFSDKPASSKSSAVLPQKDYELTPVEAENINLLATLVDRLQHQPPGTILREPQIQELYESIGALRPKLARTYGETVSKYDTLLDLHAKLSTVVRYYDRMLEERLSNTYSRQTLNAYDSVRPQSGSNFYPSMTQHNTGGHEGAENFYLGTGAPSEPHQSVYPQYPSTYSQPPQQQVHDYQGSALSSTPSFDRRASTHGSLHSQPRNSEQFSRPPPQPSYSYTPQDLTHSSPQGAESVSPPQPIAHQYPPTQYPPPSATPHQTVYTPPAPTNGQNPNYNYMSPALQPPLQHHQQQQPPPPQQQAASKPVVEESLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5I2</accession>
    <name>D4D5I2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023502.1">
        <property type="nucleotide sequence ID" value="XM_003023456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5I2"/>
    <dbReference type="GeneID" id="9583522"/>
    <dbReference type="KEGG" id="tve:TRV_02352"/>
    <dbReference type="HOGENOM" id="CLU_071111_1_0_1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="246" mass="28207" checksum="391D1E98535C83C2" modified="2010-05-18" version="1">MLHFIRLFAHMTDINYMASTLTSPIITLVVGRESRLFAAHEDILSISPFFSSAIREQVSDGDMKQIALPDEEPEILSCVLEFLYKGDYYPRLMHNKRRNSWLLEDAQDLSKTGGRGSCEATIFHSGVNDYLLRDTVIYCAAEKYGLDELKRLSLRKQGLQAGIPVDVILRSARYTYDHTPDSESRLRAHFLALIIRSRKTFKRSGTMQMEMESGGKLFFDLFVAMCNHIDDVVELRYVFQFPDCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M7</accession>
    <name>D4D5M7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023463.1">
        <property type="nucleotide sequence ID" value="XM_003023417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M7"/>
    <dbReference type="GeneID" id="9583481"/>
    <dbReference type="KEGG" id="tve:TRV_02400"/>
    <dbReference type="HOGENOM" id="CLU_027146_1_0_1"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="659" mass="76580" checksum="BC1C90980823098F" modified="2010-05-18" version="1">MHGGVLEGEEKRCDCDDIFCYLDADECIEYQAYQARLIAALRGEQVPDEEHLDNQYYAPLCLIRGIRCHYEFAASSAVKDVCVSRPALARARNARLIMSNVIPGPEDMDDTDRTRHPYCIWNPDIAAEDTYRQLAQHFPSMRYQVGRACAAAGYDGLYAELDLLPDVSIAEEARESETPGGQAIFKMIMAAPYRYAIMNDYDLSINLDSKNPGAPAFLNGHTTVRWKLQHRKELRQEAYNFRIWRARTWKWSIEEDDHIDEKESRWPDKYNILTPEEVQLLYTPLPQDLPTMKKDLLIQMAAYDGNVDRYARLASYWPMDEVERVCVIRGIYYNTMFARFWTEEIKKNTRRVQGLKNNGLSLIKEAISARRIMINDVEEFINGWPEDEPQPRVIWKPLKPCEHVLKLLAERVPSMKKTAALACIFCDYEDAYNEINCTPHPDLAMAAKESRNPFYIRDIEQRAAEQGIDLYKSYVMPIWLDESLEILKSHSMYANLTNGMGLHWSDEIMKKFSSIFGGDVPEDYPVQLYVWASPERLRLLDICETSCPCPARYYPDYEENWEEYVERAKLRKERMRRQEKRRKVRAAAALRRPGESEDAWKARQSVYFYKYNGRVRAGEPEWVEIARKAKEKYEAIVANEGGEVSEHEVSSPDSIVGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5W9</accession>
    <name>D4D5W9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023390.1">
        <property type="nucleotide sequence ID" value="XM_003023344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5W9"/>
    <dbReference type="GeneID" id="9583410"/>
    <dbReference type="KEGG" id="tve:TRV_02492"/>
    <dbReference type="HOGENOM" id="CLU_047736_0_0_1"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="47359" checksum="91E3241B365FDC7B" modified="2010-05-18" version="1">MLYEFHRSENEKKPKSVHATYLLTGISGHTKPLPLSRNHLKDGEDEVMQSSPVVGSQPAQPETTETVAGPAITSVLLVPEEELEGKSFESGLEPDYANIFYSVQPTSLPDLNVLADIGQISSTSPGDDVFQHNEKYGMIQNKNVKRRSGTPASMPTPIKEENPIQKTVVKKAEQEPPGKKSMTQSTDKKPEPSSTPFRALGSSQSTTKSSQGKPTHKRDSSSIFKAFAKSRPKQQAKDDDADSTPNESQNNMLDDESEEEREDLFLDTGKKTTNKEQESRRDREERLRKMMEDEDMPDAPESPPEEEQAPEESDQASLESTPALPQKKQEPELEPESSVSETRPTGQRRRGRRQVMKKKVSRDAEGYLADKITVSPAVTKEEPVWESFSEDEPEPQKRKPLPSSSAKSAKGGAKSSQGSIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D623</accession>
    <name>D4D623_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023320.1">
        <property type="nucleotide sequence ID" value="XM_003023274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D623"/>
    <dbReference type="GeneID" id="9583340"/>
    <dbReference type="KEGG" id="tve:TRV_02546"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="158" mass="17721" checksum="F75327CD11F31F59" modified="2010-05-18" version="1">MQTDPPAGVSASPIADNVMTWYSSCAQPYCYCMAGSVLILMSRNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFVSQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRREYTKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D691</accession>
    <name>D4D691_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023280.1">
        <property type="nucleotide sequence ID" value="XM_003023234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D691"/>
    <dbReference type="GeneID" id="9583300"/>
    <dbReference type="KEGG" id="tve:TRV_02614"/>
    <dbReference type="HOGENOM" id="CLU_022445_4_0_1"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="565" mass="63244" checksum="FE8262C56D0605AB" modified="2010-05-18" version="1">MFNQQPPSPPPSNDGDVKLSPQAISQTGFQQHPQKLQQPYPQTYSHSQPQQLHPQQQLGYIPAGEPYSYSYLEASTPAMSGPMVSIYIFPAWHKALFLTEKRLDIAEWTYHRAGEMPVPATLSAGETVEDLKEKLAIAKSNTDDRVRIIRPAKLRRRPKPAKADKGDGPTIDAPLSELTKNMLHIPIRDMAVWVNRPKETRLEEVKSKNGKIARPMNSFMLYRSAYAERTKEWCAQNNHQVVSRASGQSWPLEPPKIRDLYEGYATIERDNHHKAHPDYKFAPNKNQGTSKNQNGSKNPGSASKKKRSHEDELSDFEDQPCDITSYPRPSNRRRTLGPNGDASNSRNSTPCDNDSTYDSRNCTPIPHLQIDIYGTGDVNRSSWEMINPGRPHPGIISQPEQTHYYQPSIHQSLLGSNIEDVTYKKIGMPGGVAYDATASMVNMPGGTHPDLLQPQPLNHNRMSVSMGEVQVDPQLLDFEPTNTSLPTDTGSSFGNQNDFWQFNSTSNQHYVPGYMSTPETDQYHHAALPPSSMATGLVADRVMWPNAHTIPGEELNEWFGGSTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6B1</accession>
    <name>D4D6B1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TfdA family oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000136">
        <property type="protein sequence ID" value="EFE42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023232.1">
        <property type="nucleotide sequence ID" value="XM_003023186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6B1"/>
    <dbReference type="GeneID" id="9583249"/>
    <dbReference type="KEGG" id="tve:TRV_02636"/>
    <dbReference type="HOGENOM" id="CLU_041041_2_1_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="397" mass="44607" checksum="98C8A2949FDC0F16" modified="2010-05-18" version="1">MAPVTYDIPAAQTTTPQKPAVSLDIFPDGLKTTGQQPPLYDQIRPFSEFPKKITGPTVWKAEDYKNNPEKWTHRFTEEECAEMSAAADAFVASGIPLTAISKDNFRLPKFASFLEVLRKDIIDGKGFILFKGFPVQEWGTRKAAIAYMGLGTYLGYFVSQNSRGHALGHVKDLGEDSGKIDKVRIYRTNARQFFHTDDCDIVGLLCVAKAFEGGESDIISSHHVYNVLAEERPDVLETLTKPNWYVDRKGEVSVGEEEYIRAAIMYLEPKGGRVYTKWDPYYVQSLSRFSDAGIIPPLSPEQIEAMEVLEATCLRLSLHMVLDVGDIQFLSNSQVLHARTAYKDFPPPAPRRHLMRLWLSTPENEGGWNLPFWDTNEKKRGGIQVNDNAPVANLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6I4</accession>
    <name>D4D6I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023131.1">
        <property type="nucleotide sequence ID" value="XM_003023085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6I4"/>
    <dbReference type="GeneID" id="9583166"/>
    <dbReference type="KEGG" id="tve:TRV_02709"/>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="371"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="665" mass="72274" checksum="70174782424D283D" modified="2010-05-18" version="1">MIRGKEVLPPPVVTRTGQRKPPPPPPPSKGSRAVAAGPPLPPRNKSQAASSPVPPALPPRTPSDYSRSSSEYTPSSASVSSNSSSAEAKPNVLRVRAPAWDQTELPCVTPWKGKTKDTKDAGTERKAEEISHQPASGAQGMKGNVAALRNQLAGHKIIAPATPPPPKAAKPKLPPRMNSTPLPQVHESQHSQDRPLLERVESASTSQRKLPPPPPRGADLQKIKQFSFSSLNKTANEAVKDNTGCFDNVNRISRAPPPVPLASRPKLPPVPTSSKPQIGSTARSSTTNSTNASTICFKCRDFSTADAHAARFPRQSLPSHDLAWLSSQLTSPFPSPTDKARVIFTWLHHNVRYDVESFFQGKRTPQSPDHVFTHGLAVCAGFASLFEMLAKYAGLEAKVISGHGTGYGFKPLAPGAPIPPYEGNHAWNVVRIDNGQWKLIDCCWGAGHVEGANMPYVQKFSPKHFIMSNDEFGLDHYPENGSDFYREDGRTNITWEEYIGGGLRAQMHIPTDPPTLFDNAVEDHGIGKYTLQPGMKSISIREVSGRSIHFQFALICEHWSIVKHGGKTAASFFVLAPHGLDGREDKFVPFNHVRGTNAGGGGDYWYLDIPDGRTLGCAGQKLMIFELTSFGTRTDLRGLTMAEYEQGVGRVGMGFKALAEWTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q0</accession>
    <name>D4D6Q0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ chaperone (Caj1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023087.1">
        <property type="nucleotide sequence ID" value="XM_003023041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q0"/>
    <dbReference type="GeneID" id="9583107"/>
    <dbReference type="KEGG" id="tve:TRV_02777"/>
    <dbReference type="HOGENOM" id="CLU_073129_3_0_1"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="201" mass="22106" checksum="1CD518DB375A193D" modified="2010-05-18" version="1">MKTLQQYSDNGGTDPSRAALKYHPDRVPLTSPERPERTKKFQQVNDAYYTLSDKNRRSAYTTAYNTKTGYFKNAYAPPPQSNEYSAEQFGDFFEEMLRENGMMNGGRGGVGADDPGSKKYDLNVSGAWFWSIMGAIGGAILGFIIANAAGMVAGMVLGNRIGAIRDREGRSVYSVYQDLPASDRAKLLSQLAARMLRSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D701</accession>
    <name>D4D701_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022974.1">
        <property type="nucleotide sequence ID" value="XM_003022928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D701"/>
    <dbReference type="GeneID" id="9582993"/>
    <dbReference type="KEGG" id="tve:TRV_02879"/>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="458" mass="52088" checksum="BD280D88D288C4B6" modified="2010-05-18" version="1">MVKKKSSRGKSESEKNGQKTEQNRKLNTTITRVVRGIAAMAHCEAASKPILQCLRQAYRGRLAASQLRLDRSFSSTAAISTSAETEAAASKESFYKAIDPELVSSPRLERRLIRAGKFPVGSRRRRAALQGSPNYPFEQLPFQCFQEARKVLQEDREEKLQQIEKERARLARLREADPATVGGEAQHQTRIKSMEKHLEKLKILADINDPLVKKRFEDGMGDMSKPIYRHLANQKWREYRRLILIQRLTQMKVIPDVLPHIDPIVDVQLFFGKKQIQPGVFVDSRVSMVPPSLNIQSFDKGEKLVTIAVVDPDIPNLESDSFDNKAIFLAVNVPISPTSTSVSLEGLSESQVILPWTAPYSLKGSPYHRISIFVMEQKDQKPLDRNVVAEKANRDSRLRSLETRHQLKPLGATLFRTQWDDNMASVMEELGIEGADLELKRKRVEPLPYKRRNPASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D711</accession>
    <name>D4D711_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022984.1">
        <property type="nucleotide sequence ID" value="XM_003022938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D711"/>
    <dbReference type="GeneID" id="9583004"/>
    <dbReference type="KEGG" id="tve:TRV_02890"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="112"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="500"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="671" mass="75836" checksum="70CA10B382474993" modified="2010-05-18" version="1">MFHNHLSRLHDILSEFAHILKSDSRNMALDPRFYSNIGGQSDHFASQGRVCTPPVESPAQYYYPGATPSMASFTSASSAALRSTASTPSFRSRESVMAPAPKVDAPISSGGNVKVVVRVRAFLPRGLTPYMFPIWIQIFSFFKLNSNSRSKAVEDKSFTFDNSFWSHNRADPHYAEQEDVYNCLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGTPEQPGLIPRTCEDLFQRIENSNSPDITYNVRVSYFEVYNEHVRDLLVPRTDPPYYLKIRESPTDGPYVKDLTDVPVRNIDEIMRYMRKGDASRTIASTKMNDTSSRSHAVFTIMLKQIHHDLSSDETTERVARIRLVDLAGSERAKSTEATGKRLREGSNINKSLTTLGRVIAALADTKQRQNGRKARDIVPYRDSILTWLLKDSLGGNSKTAMIACIAPGDYDETLSTLRYANQAKRIRNRAVVNQDHISAAQRDAEIAEMAEMIRTLQLSVSQQAVTKRESELQTEKLEEYQKQVTRMQQLMEEMKMVSETKIRQLQTENEALRLHLKLALESLKNPIPPVQVPKQRNRQSSVRSLLAKDEGNIEILEEDAEKENTAPPGFDDQIGDSKPGLSRFDLEALEVQAEMEDLLSDLNMFRKKLADDCERFGVKKRPARPSHAARKVLGELEANNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D743</accession>
    <name>D4D743_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022935.1">
        <property type="nucleotide sequence ID" value="XM_003022889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D743"/>
    <dbReference type="GeneID" id="9576961"/>
    <dbReference type="KEGG" id="tve:TRV_02922"/>
    <dbReference type="HOGENOM" id="CLU_054430_1_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="193" mass="21758" checksum="E84CDB25693892B0" modified="2010-05-18" version="1">MTSVGTRIVGKSGNQYVIERLLQEKIPPDIRVYLANNGTEKFILKNVHDFDYYHDIYRRISSSPCLRLLHDTVPDQSIFVYEYLTDHLLNMAKKDIPIVATKRILRDALCGLKGLHDQNIVHTGRGFDNIFLLPSDLEPITHISAIDIKANNILIDWKEKNGELAIGRVQLADIEDSAIIPPNCDILGKAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D787</accession>
    <name>D4D787_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022886.1">
        <property type="nucleotide sequence ID" value="XM_003022840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D787"/>
    <dbReference type="GeneID" id="9576924"/>
    <dbReference type="KEGG" id="tve:TRV_02968"/>
    <dbReference type="HOGENOM" id="CLU_032951_0_0_1"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="56034" checksum="35B3D3081ACEC94D" modified="2010-05-18" version="1">MNSYILNRSQGSIHPFQFHFAQCTRLVHGLAAAPGIRFSAGKQHKSQPGAADIAQETPDIRHSDFDFEDIWAHKAGVNVLAIDQYEKRYTEKLQVTKRINLSMISGGADTSIHLWDLEGQGTELNYLHQPVASVSKQTNASTHTHALTSLSIYPFDPTPSTILSTSHDATLKLSSLGESDIVPVHTFNLHSTPYSHSLSAHQASHLLIAVGTSENAIRLLDLRSGLSTHALPAHTGAVISVQWAPHNPHLIASGSKDNRVIIFDVRRSGRNSAIASFDMDDSMGILSLERSASQQTRQSGKLFSSSSRAHNGTVTGVRWTSNGSHLLSAGQDSRIRVWDASTGANTLIHFGPRIRNSASLHLAERAPLILPENNSVVTLSQGHGAVLWPNYNDQDDRGEIFMFEIHDGTQIKHLRVPGLISREKLRGRPTALSAARINALSWRGNGASGEGMEMFSAHGDGTIRSWTSRTEEDEEFEAEAVHNEQEEKKRKRDILDEVYRGLMQPGITFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D5</accession>
    <name>D4D7D5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022855.1">
        <property type="nucleotide sequence ID" value="XM_003022809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D5"/>
    <dbReference type="GeneID" id="9581579"/>
    <dbReference type="KEGG" id="tve:TRV_03017"/>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="805" mass="89528" checksum="33BDEDF824FA2250" modified="2010-05-18" version="1">MAFLTARELTLEAAQSASSVRSLRPSSYASRTASVSQIKKLLDSRNDRDILDGLRKVISLMYRAEPCLPFFSAVVKNVANPNIEVKKLVYIYLLHHAEAEPDLALLSINAIQKSLTDQNPQVRSLALRTMSGMKVPVISQIVSLAIKRGCGDMSPHVRKAAALAIPKCYRLDPGTLPQLIDYLSILLGDNQYFVVGPAVAAFLEICPEKIELIHKHYRSLVKKLVDMDEWSQLVTLRLMVFYARKCFPRRTQKVKKSNPKGFYEDENEEDTQENDLSEEEVDIVDPDLELLLKACKPLLQSRNSAVIVAVVRCFRYLGTVENLESATGSLIALLRSPQDLQHVALYNIISVALISPKPFVKYASHFLVRSTDLPHIWRLKLEILTMLFPHCGNHFKGVILSELEHFSNGSDHDLVRESVRAIGRCAEAHTGSSTRCLQLLLRQITSADDVLVSEAVTVIRHLIQQDTAAHKGTVVMLGNHLGTTSSPGARASIIWLVGEFAGIDPHNNIAPDVLRLLAKGFSDESETAKQQILLLGAKVYLHHLLNSPTISSDPKSSSDNGQDDNRELDANDQVSSPKEEDSITTLWRYILLLARYDTSYDLRDRARLYKSLLAVPSSTQLASLLLLAPKPIPHTSTPSETRKNLLIGSSTLVIGPDAGMYGLRGYEDLPDWVEAGHEPDPKLRDDDSIKSGAYGEKANATAGERLDKALQEHNVVSGKGNVNGRIGNVPKNMSLDDWLAEEEEEEEEYEEDDEEETEEETDEEGEEEEEEETEYETDESGEEEGEEEPDQQHAQSGAESAKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7N0</accession>
    <name>D4D7N0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022732.1">
        <property type="nucleotide sequence ID" value="XM_003022686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7N0"/>
    <dbReference type="GeneID" id="9581420"/>
    <dbReference type="KEGG" id="tve:TRV_03114"/>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="518" mass="56411" checksum="82FADFD77DB36180" modified="2010-05-18" version="1">MAAAVRDTVTNLIGKIAGMGVQDAPPRQPSAEEVAELKKQYEQAKQGQVFARFDSLTSSEQAQLFHQLSSFDPEHINKLVKRANEDSANALSSNEPKALEPLPESSTASILDSDPKDIEQWYNQGLKLIGENKVAVVLMAGGQGTRLGSSDPKGCFDIGLPSGKSLFQIQAERIAKLQSLAAGESSKENIVVPWYIMTSGPTRQATEKFFTDNNYFGLCKENVMIFNQGVLPCISNEGEILLESASKVAVAPDGNGGIYQALVNSGVQDDMKKRGIEHIHAYCVDNCLVKVADPTFIGFAASKKVDIATKVVRKRNATESVGLIVLSNGKPGVVEYSEIDEATANAIDPKQPGVLKFRAANIVNHYYSFSFFESIEKWSSDLPHHIARKKIPFYDTKTGATVKPESPNGIKLEQFVFDVFPFISLEKFAAIEVKREEEFSPLKNARGSKDDNPDTSKKDIMQQGLRWIKAAGAVVSEEHTSLGIEVSPSISYGGEGLAFLKGRTISTPALIETECDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7N7</accession>
    <name>D4D7N7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022739.1">
        <property type="nucleotide sequence ID" value="XM_003022693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7N7"/>
    <dbReference type="GeneID" id="9581429"/>
    <dbReference type="KEGG" id="tve:TRV_03121"/>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="331" mass="36780" checksum="23BD01F456FFF2D1" modified="2010-05-18" version="1">MTFAESFLQGFSTVHNSIGYKKGYNFILWFIFAGALLGFTLARFSFLNFDVFESDSVPGQWYFTRMGRDKVGLLLHLAAVLPCGILVIFQFIPIIRHKWILFHRINGYIIFILLLISHAGALMIMEHSFGGGVDIQSAVITLVIACTVSFCLALYNIRCKQLEQHRAWMLRTMFYMGCIITIRICLIISASILGALPNLRHDVWSCDQVRFTFLNGASDALTASEKLAKLFPQCTAPNSTNIMVPVPASLNLSNPASAGAAFNLSFGTAIWISFMLHALGVEIYLRLTPKEAERLRQISYERQLAAGFKNPGSAGLVVEKLGDADPWKGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7P0</accession>
    <name>D4D7P0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022742.1">
        <property type="nucleotide sequence ID" value="XM_003022696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7P0"/>
    <dbReference type="GeneID" id="9581432"/>
    <dbReference type="KEGG" id="tve:TRV_03124"/>
    <dbReference type="HOGENOM" id="CLU_043566_0_0_1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="277" mass="30513" checksum="2235AED8F75E7507" modified="2010-05-18" version="1">MSTVSSPRPSIASARSPTPASSRRPSVESANFAPRTDLPSNALRRNRAALRDYYNLHPGRTEPSNQSRARSVPPTPDGARPINQISNSELDSPNFDPDDYVSHLLATSSLATILRAENSLVSDIKTLDGERKALVYDNYSKLIKAVETIGKMRSILEEEGTPVLMTKTLAPAVGFIAETAMSLIREQQELRPSTNKPAQASATQNETAVKPEKATVLWALDSPRRLKRLLDSGKRDDAEQDWSEIQSLLSKWGEVKGVKELRAECELLIVKKELPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7V0</accession>
    <name>D4D7V0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_03184</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022663.1">
        <property type="nucleotide sequence ID" value="XM_003022617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581350"/>
    <dbReference type="KEGG" id="tve:TRV_03184"/>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1931"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2588"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2930"/>
            <end position="3096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3192"/>
            <end position="3254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3418"/>
            <end position="3459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="4346" mass="491194" checksum="681FF0631EFF5583" modified="2010-05-18" version="1">[encoded data, 4346 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D823</accession>
    <name>D4D823_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_03258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022601.1">
        <property type="nucleotide sequence ID" value="XM_003022555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D823"/>
    <dbReference type="GeneID" id="9581260"/>
    <dbReference type="KEGG" id="tve:TRV_03258"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE41983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="56994" checksum="E375950B04A4787B" modified="2010-05-18" version="1">MAKVENKAVLIVIDGWGIPGPDSPKDGDAIAAAETPVMSGFAQEGSKTAQGYTEIDASSTAVGLPEGLMGNSEVGHLNIGAGRVVWQDVVRIDQTLKKGQLGKVENIVKSFENAKNGNGRLHLLGLISDGGVHSHINHLFGLLQVAKEMCVPKVFIHFFGDGRDTDPKSAAGYMEQLLQKTQELGVGELATVVGRYYAMDRDKRWDRIEIAMKGIVTGEGEESHDAVKTIKERYEKGENDEFLKPIIFGGQERRVQDNDTLFFFNYRSDRVREITQLLGDVDRSPKPDFPYPKNISITTMTRYKTDYTFPIAFAPQHMGNVLAEWLSKKHLKQCHIAETEKYAHVTFFFNGGVEKQFEGEDREMIPSPKVATYDLDPKMSAKPVGEKLAERIADGKYEFLMNNFAPPDMVGHTGVYEAAIQGVAATDAAIGCVYEACKKHGYILFVTADHGNAEEMKNADGTPKTSHTTNFVPFVMANAPEGWSLKKSGGVLGDVAPTVLAAMGIEQPEEMDGTSLLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8D7</accession>
    <name>D4D8D7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTR family peptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000175">
        <property type="protein sequence ID" value="EFE41880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022498.1">
        <property type="nucleotide sequence ID" value="XM_003022452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8D7"/>
    <dbReference type="GeneID" id="9581079"/>
    <dbReference type="KEGG" id="tve:TRV_03373"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="579" mass="63563" checksum="03A4E2C14D7FBFAD" modified="2010-05-18" version="1">MADKEAVPVQATEQHDEKQVIKDVAQDPVLDTKAGSDIDAEKGEGFETPDGEEPTESEKFNLRHIGESLPLSAWLVAVVELCERFTYYGMNGLFQNYIQRPFDGSEGVGALVLTGVGLGHQGATGLTTFFQFWCYVTPIFGAIVADQYLGKYKAILYFCFVYMAGLIILVATSVHSSLAHGAGLGGFIASIIIIGIGTGGIKSNVAPLIADQYKRRVPAISTLPTGERVVIDPAITIQRIYMIFYACINIGSLSLLATPYMELYIGFWSAYLLCLCVFVVGTVTLILGRKAYVVRPPTGSIITNAFSALWIMVTTRNMDGPKPSYQAEHGNRRTVAWDDQFVDELKRALVACKVFCFYPIYWVVYNQFSGNFVSQAAQMEGHGIPNDLMQNFDPIAILVFIPILDRIVYPIMQKLHIPFPPISRISVGFIVASLAMAYAAIVQHLIYSAGPCYEHPLACPEGKVNGVALGNHVHIAIQTPAYMLIGISEIFASVSGLEYAYTKAPVSMKSFVQSMYLLTNAFGSAIGEALVPVAYDPAIKWMFVSLACVSFSTGILFFFIFRGLNAKEEEMNRMDKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8L8</accession>
    <name>D4D8L8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022391.1">
        <property type="nucleotide sequence ID" value="XM_003022345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8L8"/>
    <dbReference type="GeneID" id="9580938"/>
    <dbReference type="KEGG" id="tve:TRV_03455"/>
    <dbReference type="HOGENOM" id="CLU_2428638_0_0_1"/>
    <dbReference type="OrthoDB" id="5425892at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="91" mass="10372" checksum="14DFCC518C550360" modified="2010-05-18" version="1">MITEEQANQLYHEPKTGSFEAPNVHDHNTGHTSSAISSTESSPQLRQGEWRPQHKSRQYSFDAQEQKHKLQSRLTGLVKGKETGFTEREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S5</accession>
    <name>D4D8S5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022302.1">
        <property type="nucleotide sequence ID" value="XM_003022256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S5"/>
    <dbReference type="GeneID" id="9576905"/>
    <dbReference type="KEGG" id="tve:TRV_03513"/>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="346"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="550" mass="63812" checksum="AEEFBE2ED90A2DE7" modified="2010-05-18" version="1">MHSQERAACFAAQRREARDDAADEDGERREGHSIFDSSDDSDTRFIMMQYDRNRVDTKRRAGIDHKKRQFATPVYKHLQYSHRLNFYEVPPTAEITLEQFEQWAIDRLRVLSELEACSYRNKTPAETAAHIAPLLKKFLPLNSNTSLGSSSDDILQAERQKDHYSHFILRLAFASTDDLRRRFVRLESMLFKFRFQQDDARERREFVDSLHLDWETVTDEEKAELGEALLASTPGLRWVDDESWFKVDWEAVPELIERRSIYVKKGKAYVPLREQLSMILAEFTSRLEKAMELTSRALPRLDEDDRLSPILQHLSKNFGTADSSYSEGEGAVPGAPINAASVDVLAQHFPLCMRNLHMQLRKNAHLKHFGRLQYTLFLKGIGLSLDDCLVFWRRSFRNITDDEFNSRYKYNVRHAYGDVGGDMNRRGRGYPPYSCQKILTDNAPGTGQTHGCPYRHFSPDNLVSLLEAVGITDRETLRGVREDVGRTRYHIACNRVFEHVHKNELKKVRDEGIWSQTELDTIVHPNVYFKRSYLLKNLNNAPKTEVEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8T5</accession>
    <name>D4D8T5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022312.1">
        <property type="nucleotide sequence ID" value="XM_003022266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8T5"/>
    <dbReference type="GeneID" id="9580859"/>
    <dbReference type="KEGG" id="tve:TRV_03523"/>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="31417" checksum="4E49106199EDBB1A" modified="2010-05-18" version="1">MFSRTARPAWKAGSAAVARVAPANAANFATLREIEGRLKSIKNIEKITKTMKIVASTRLNKAQRAMTLSRAYGETSEAVFGQAETKPLEGLKTLYIVASSDKGLCGGIHSGLSKATRRMIMEKPDADIVVLGEKSKGQLSRSNEDNLVLSFAGVGKDVPTFAEAQAIADQICQLPTDYASIKIVYNKFINAQAYEPTTVEAFSEEAIIQSPNVVAFEVDSEVLANLREYALANSLYWALAEGHACEISNASKNAGDMIQRFQILYNRQRQAAITGELVEIITGATASEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y6</accession>
    <name>D4D8Y6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022363.1">
        <property type="nucleotide sequence ID" value="XM_003022317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y6"/>
    <dbReference type="GeneID" id="9580910"/>
    <dbReference type="KEGG" id="tve:TRV_03574"/>
    <dbReference type="HOGENOM" id="CLU_1571750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="170" mass="18252" checksum="88D1884159F9765C" modified="2010-05-18" version="1">MSAPDQSSNARPLFLARFRQCGFTCRHTEHWGLFLARSWDQCAEGTLFHVVYSGNPTVSASVHAVTGSYSHGYFNVPKFHPNTSGQLTGLSSIITAAQGGISASTLHQVSQAIDAQFPYNIANNNCQNFVIRVLQELHKQGKVTTEALSSVAGRVGGTVFTPPAGNWATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y9</accession>
    <name>D4D8Y9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_03577</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022366.1">
        <property type="nucleotide sequence ID" value="XM_003022320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y9"/>
    <dbReference type="GeneID" id="9580913"/>
    <dbReference type="KEGG" id="tve:TRV_03577"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="432"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE41748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="763" mass="85511" checksum="2F2D89A0D2B73824" modified="2010-05-18" version="1">MGRLRELKKATEAYWGGKISRDELLSEGKRLRLEHWKIQKDAGVDLIPSNDFAFYDQVLDHIQLFGAIPERYSKYGLDPIDEYFAMGRGHQTPATDKESAVDVPSLEMVKWFDSNYHYVKPTLQDNQVFKLSATPKPVVEFKEAKEAGIVTRPVLLGPVSFLALAKADRGQKVDPISLIEKLVPLYVDLLAQLKEAGAESVQIDEPVLVFDLRDAVKAAFKPTYEKLGALGDKAPKLVFTTYFGDIVHNIDVLANLQSLHAIHIDLVRNPEQLETVIGALGPKQVLSAGVVDGRNIWKTNFKRAIETVELAIQKLGKDRVIVATSSSLLHTPHTLASEKNLDAEVHDWFSFAVEKASELVVIAKAVTDGPASVREALEANAKSIQARAASKRTNDPKVKERQAAVTADMHKRKSEFPDRIAVQQKELNLPMFPTTTIGSFPQTSQIRVQRNKFTKGEITAEEYEKFIEKEIQDVVKIQEDLDLDVFVHGEPERNDMVQYFGERLTGYVFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAASISKKPMKGMLTGPITCLRWSFPRDDVHQSVQAQQLALALRDEVVDLEAAGIFVIQVDEPALREGLPLRAGAARDAYLKWAVESFRLATSGVADGTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFVDEAYPRHIGPGVYDIHSPRVPGEEEIKARIEEMLQYLRPDQLWIDPDCGLKTRKWPETKAALVNMVNAAKFFRQKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D944</accession>
    <name>D4D944_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022231.1">
        <property type="nucleotide sequence ID" value="XM_003022185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D944"/>
    <dbReference type="GeneID" id="9576833"/>
    <dbReference type="KEGG" id="tve:TRV_03634"/>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="494" mass="56540" checksum="8D06506ADA4D7870" modified="2010-05-18" version="1">MHTEQQNGREELLQPCYYRVTLNKETDTEEERTALLNACHQRCADRTLKVLEKNGSIFIKLGQHLSSLGYLLPLEWTTTFIPLQDKCPVSSFESVQEMFLRDTGHTIDEIFSSFDPMPIGAASLAQVHVAVLRETGQKVAVKVQHPTLQEWAPLDLSLTRFTFSSLKRVFPEYDLEWLAREMDFSLPQELDFQMEAENARVAREYFSKRTNAPLIIPKGRRPPELYSSVSCPADIVLIVVIWAKKRLLVMEFISGHRPDDLEFLDSNNIDRDEVSASLAHIFNEMIFGDGAPLHCDPHGGNIAICKNNTRKRGPNFDIVLYDHGLYRTIPKEMRINYAKLWLAVINADEKEMRKYAYEVAGVTDEEFPLFASAITGRDYTVLAQNQVASSRSSEEKESITTALGDGMLQELVSLLGKVPRIMLLILKTNDLTKYATCAVFSQEMELISQQGSIFWPPNFLRFLQAWVSYLRVEIKLEIYEHWLSLRNRLGLTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9D5</accession>
    <name>D4D9D5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TRV_03726</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000190">
        <property type="protein sequence ID" value="EFE41548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022166.1">
        <property type="nucleotide sequence ID" value="XM_003022120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9D5"/>
    <dbReference type="GeneID" id="9579047"/>
    <dbReference type="KEGG" id="tve:TRV_03726"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EFE41548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="40681" checksum="DA163B183944E15B" modified="2010-05-18" version="1" fragment="single">KNNSRFKPDKEGETIQYTGLSQSAVREIALCTELNHPNVVRLVEIILEDRCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMVKSILFQLLNGLLYLHSNWVLHRDLKPANILVTSCGAVRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLLGCRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKNVPFQRNQMLKIMEILGMPLKQNWPGLASMPEYGQLQAFALGPGTSHIHKPSSLEPWYNACLKNGSYSPSSTAGTPGKEGFDLLSRLLEYNPAKRITAKEALEHPYFSTGSPITANCLEGFEGKYPNRRVSQDDNDIRTSSLPGTKRSGLPDDSLTSRAAKRVREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M5</accession>
    <name>D4D9M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022077.1">
        <property type="nucleotide sequence ID" value="XM_003022031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M5"/>
    <dbReference type="GeneID" id="9578961"/>
    <dbReference type="KEGG" id="tve:TRV_03818"/>
    <dbReference type="HOGENOM" id="CLU_512831_0_0_1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="534" mass="58096" checksum="E678CEF1F2B8CBDE" modified="2010-05-18" version="1">MGRFDGLPTELILQICDNLSPQDSFAVALASRKLATILLPRARIITLSYAADMKKRDLFLKTLEKDVDFSLVLVDRTILEECILTQDDEYVLPMLERGVGLVSPPGSVCASTGVNLLHLAASAGCGDTVLKRLLVHGDEIDPFAKDEDGITPLVCAVTKRKLAAVKTLIGIYHERGREIDPPDSKCPLILQAMPRGYGEIVLFLLETKGIQVNARGPFGENALHWLAKTDMTPEDEDAWEDTDDEDGDFTAQEVVNINQQGREDGDSHVADSEETEDVNVKVLKGLLKAGVSLTDTATRDRLTPLHAIALNGRYNLIEPIVTGGADISVRCANGGTPLHWAAKGGSVFSMDALIDLGASVNDTDLENKTPLFWAYACENADDPPSEFDPSPYPILYLLEQGANLSHLDSSNQSALHIFAQHDRPNGATQLLAAGIDVNIQRNDGSTALHLAALNGSHKTAAQLLRARPNLELKNAQGQTALEVAVEKGKDKVAKLIRSYTRRGVTAVGGVINDRSMEDLHDRLTTQLSIYEWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA21</accession>
    <name>D4DA21_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021935.1">
        <property type="nucleotide sequence ID" value="XM_003021889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA21"/>
    <dbReference type="GeneID" id="9578818"/>
    <dbReference type="KEGG" id="tve:TRV_03965"/>
    <dbReference type="HOGENOM" id="CLU_2706589_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056326" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="73" mass="7809" checksum="ADEB02C684CDCBCE" modified="2010-05-18" version="1">MALVAQVQGLLLAWIASGVADAAAGVRKKKTWADEGPKEDGAEEEQCLLSINVIVVHGIPYLISVMLEPEYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA85</accession>
    <name>D4DA85_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04031</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021854.1">
        <property type="nucleotide sequence ID" value="XM_003021808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA85"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="GeneID" id="9578736"/>
    <dbReference type="KEGG" id="tve:TRV_04031"/>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="249"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="597"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE41236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="767" mass="82547" checksum="1C8068A6F82E37B0" modified="2010-05-18" version="1">MALVDHSPNHPTPSGRLENASNVILIDNYDSFTWNLYQYLVLEGATVRVIRNDAATLEELIAEKPTQLVLSPGPGHPKTDAGICNEAIQHFAGKIPIFGVCMGQQCIISSFGGEVDVAGEILHGKTSPLKHDSKGVYASLPASLNITRYHSLAGSATTIPDCLEISSTTDLGDPNRPDVIMGVRHKKFTVEGVQFHPESILTEHGRAMFRNFLLTRGGTWEEHDASAPGPATVPSTNGQSSEMKKGSILDKIYAHRQSAVKVQKEIPSQRPEDLQAAYDLGISPPQISFPDRLARSPFPLSLMAEIKRASPSKGIIAASICAPAQARKYAMAGASVISVLTEPEWFKGSLDDLRAVRQSLEGIPNRPAILRKEFVFDEYQILEARLAGADTVLLIVKMLAEPLLKRLFDYSRKLGMEPLVEVNNPEEMEIAVRLGSKVIGVNNRNLQSFEVDLETTSRLMGQVPESTIVCALSGISGPQDVAPYQKNGVKAVLVGEALMRAQDVGVFVSKLFGTKPGPFAQTPGAPLVKICGTRSATAAKAAIEGGADLIGIILAEGRSRTVSTETALEISKTVKSTPRPSSLKTQPPAYGDAFLASNYFDHTTGLLRNPDRALLVGVFQNQPLSYIVAQQQKLDLDVIQLHGSEPVEWPSLLPVPVIKKFSPSDLGISRRGYHSLPLLDSGAGGTGERLALEQVKDVLKKDPGQRIILAGGLDDKNVTDVLRALGEEGNKVVGVDVSSGVETDGAQDVEKIKAFITAAKNIRNTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN8</accession>
    <name>D4DAN8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021675.1">
        <property type="nucleotide sequence ID" value="XM_003021629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN8"/>
    <dbReference type="GeneID" id="9576758"/>
    <dbReference type="KEGG" id="tve:TRV_04186"/>
    <dbReference type="HOGENOM" id="CLU_2559953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="82" mass="9419" checksum="DAEC17D9B3BDB213" modified="2010-05-18" version="1">MAELVKDIEKDGEKKKKKKKKKKLRRREARSLFVLYRANSCVRTALNNTVAGLPARLKHQAREVEQKCQTGRSGFAACCLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAY7</accession>
    <name>D4DAY7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing polyketide synthase nscA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Conidial yellow pigment biosynthesis polyketide synthase nscA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Neosartoricin B biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021612.1">
        <property type="nucleotide sequence ID" value="XM_003021566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578573"/>
    <dbReference type="KEGG" id="tve:TRV_04285"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="2"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="939"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2413"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="939"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2492"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2540"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2556"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2578" mass="280340" checksum="F255887A2BC7A757" modified="2010-05-18" version="1">MIEPIAIIGSGFRFPGGADTPSKLWSVIHNPRDLSSKPPTSRFDIDSFYHPVGTHHGTTNATKSYWLEDTDKSNVTKFDAGFFNIQPSEVDAMDPQQRVLMEVVYDGLCAAGQPMEKLRGSDTAVYVGLMSDDWSTMLTRDWETLPRYTATGLERGIVANRVSYFFDWHGPSMTIDTACSSSLVALDLGVQALRSGKSKVAVAAGTNLILSPAMYISESNLGMLSPTGRCAMWDASADGYARGEGVAAVVLKTLSQAIADNDPIECIIRETAVNQDGKTTGLTMPSNVAQTNLIRECYARAGLDPVNNLEDRPQFFHAHGTGTQAGDPQEAEAISNALFPAGSYADKMADKLLVGSIKTVIGHTEGTAGLASVISTSLALKYGVVPPNLHFANLSAKVAPFFKHLDIPTVPTPWPAKEGQLRRASVNSFGFGGTNAHCILEQYIPEKKAVSPIFTPLTFSASSEIALREMLSQHLDYLVSNPETEFSDLAYTLQHRRSTLSYRKAIAAMTIQDAIKSLDEIVNSTSSATGNAEFGTRFGTISDPKIIGIFTGQGAQWPRMGAQLLETSLFAASRISELDSALQSLPSPGDRPAWTLKDQLLAGKDTSRIAEAALSQPLCTAVQIILVDILREAGISFRAVVGHSSGEIGAAYAAGFISAQDAIRVAYFRGVHARLATSPNGHAPRGAMMAVGASADDARDFCATTGFSGRLQVAAVNSASSVTLSGDEDAVTEAEEIFKSQGIFARKLKADTAYHSAHMASCAGPYFSSLEGCAIQSVAPPQESATTWFSSVYAGEPMTSDRLTNQYWVDNMCNAVLFADALSKALKHVDQFDLAIEVGPHPALKGPATSTIGSIPYTGLLSRGLDDVTQLSDALGFIWTRLGSGSVRFSDVETLLSGVQSRKSLKDLPSYPFEHQRNYWTNSRLANHFKNRRAIHLPNPVLGSPCSEATTPGEFQWRNFLRPNDMPWLKGHRLQGQTVFPATGYVSMAVEAIKGIVFDNEAGNSISMIRLTDVDIPRAIAFNDDDSNIEIIFSLSSIDISPTAITAEWGCYSVADGSNILLNAKGKVSVQLSSAKPDTLPLVKAEPFNLVAVQDDRFYSNLSTVGYGYSHPFRGVSDIQRKSGYSIGTLFDQSGSEWDDNLILHPGMLDSALQTVFAAWSYPGDTQLWSLHVPVSISAVTINPYFTILGAGGKQGTMKFETLIRSKQRSQIIGDIYLNTDNKSHAIVQFEGATLVPFSPATPKNDLPMFSHFEYRVASPDGLLAAEGETVTDFEVQMYKDIDRVSYWFARHASISIPAEERAGLLPHFQKYLQWCDRMVGMVSRGETPKVGPECNNDSREDIGKILARYEGRKDIRFVEVVGDNLIPVIRAGNSMLEHMNQDGLLRAFYEENAICAGPTSRWLARVVSQISHRYPGLNIFEIGAGTGATISSVLRNLKGSYSSYTFTDISSGFFMAAEERFAKESGRMTFKVFDMEKGPAEQGFIEGSYDLIVAVNVLHVSADMEASMSNIRRLLKPGGYIVVGELTSTDLLFSGMTVGTLPGWWIGAETGRPWGPLLTLDQWDSVLKKTGFSGIDTVTPNIDSSLPISVFVGQAINDQVTLLRNPLSVQEHPVGVRTDALAIIGGTTDRVKELGHNVSGILSHRFPVKEFFDTVEDFACSTMARSVSISGAVTILSLTDLDQPYLDGLTADKFNALKTCTTAGTVVWVTCGSREDTPYSYMMMGFARTIKNENPDLNLQLFDLDSKAAKDGIEPQTAAILAETLLRQRVLQSWGIDEDALLWTDEPEVFMDNGKQLITRLLPDPEKNMRYNSQRREVFTEANPMIDTLELVGAGSGKGRVLELHKVSPLRLPNIPETKYRTLRITHSLLQTVAVGAAGFFRLCMGVDVNSNETILALSSSPESPVNVPEYCCIAVPRTFDNNTLVSIASSIVAERVLSFTPEGGILLVNEADPSLVSAIQRKASAKDVKPVFITAKLRQNSNGDSLFLHPNFPRHIIKSIVPETTAVFLHFLRGDTSDAVRDCIIPCLPASCLQINEEAVLGHELTEVSSAKSLIDLSQILQSALNDTDKAASEDANYISLDSLPSHGIIGEPMTVVQWTTSTPLTAKVQPIDSGMLFKANRTYLFVGMAGELGQSLAGWMIAHGARNIVLTSRTPKVNPSFIEDMKKRYGAVVKAMPLNVTSRESLHYVHTAITATLPPIAGVVNGAMILEDELFSRMTYEQYTRVIEPKVLGTQLSDERFYDDKSLDFFIVASSIASVIGWSGQSNYSAANEYMTSLVYKRRNRGVAASAMSIPAVLGVGYAANSINFDFDYFQSVGYINISEEDLHILFAEAVVSGRPSQAPQVKAQVAMGVNYLPNDFFVQEAHRRDVKFNHFIQREETGSEIQAVKSGVRVRVQLQAAKNAEDSYIITRDAFLSHLKRMLRMTEEQKLEDSIALVDQGVDSLVAVDIRSWFLKELEVDIPTLKILGGGSIADLVKTALENMEPIKEDAPESSEPSPKQKPQPGKPSGSIPKKETASSSPLSMGSPVFTPALGDTPSPSDDDSISTPLPSREDFVKKGDLKSQGKPVPTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAY9</accession>
    <name>D4DAY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021614.1">
        <property type="nucleotide sequence ID" value="XM_003021568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAY9"/>
    <dbReference type="GeneID" id="9578575"/>
    <dbReference type="KEGG" id="tve:TRV_04288"/>
    <dbReference type="HOGENOM" id="CLU_117710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="144" mass="16217" checksum="ADC3AE6DD2EF2A7A" modified="2010-05-18" version="1">MKGKNPWANAANAGQDKDGILSIYTKATLDSRQKTPALNGFKSAHSSSKDKRKETKHQKSKTEELTIWRPKSQNVYSRTKPGYCGIKRLDEEPEEDEKEMGGRKRNEMNLLHPAEDDGWPVTSRHANPGVISIPPSWNQLIYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAZ8</accession>
    <name>D4DAZ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021588.1">
        <property type="nucleotide sequence ID" value="XM_003021542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAZ8"/>
    <dbReference type="GeneID" id="9578549"/>
    <dbReference type="KEGG" id="tve:TRV_04297"/>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="6">
        <location>
            <begin position="603"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="91478" checksum="C3442FEC7CE7CC33" modified="2010-05-18" version="1">MPGEVIDQPNPRPPPSQLPDSVDELRVRLQTVKLDDGVRRSLEKFRRATDYIAAAMIFLQSNAYMKRPVKPEDIKPRLLGTRQGHWGTCPGLNLVYSHLTYMIRCHDLDMLFVTGPGHGAPAILASLWVEGSLGKFYPKYANDTNGLTKLITQFSTTGGFPSHINAETPGAIHEGGELGYALAVSFGSVMDNPDLITAVVVGDGEAESGPCTASWNGIKYIDPAESGAVLPILHLNGFKISERTIYGCMDDRELVSLFSGFGYQARIVEGLDDIDTNLNSSLEWALAEIRRIQKAARSGSPIMKPRWPMLILRTPKGWTGPKSIHGKIVEGSFAAHQVPLPAAGKDEEELKALQEWLSSYKPEELFNERGDVIDDIKSILPKEDSKRMGQRKEVCDTFEKLKMPDWRRYTVSKGSQESSMKTISHFMGQILMDNPHSMRIFSPDELESNKLGAVLEKTGRNFQCDQFSNARGGRVIEVLSEHMCQGFLQGYTLTGRTGIFPSYESFLGIIHTMMVQYSKFNKMGMETNWRRPLPSINYIETSTWARQEHNGFSHQNPSFISAVLNLKPNAARVYLPPDANTFLSTLSHCLQSKNYVNLMIGSKQPTQIYLSAEEAETHCRAGGSTWGFASTDGGLDPDVVLVGIGTEVTFEVIQAAAILRKVVPDLRVRVVNVTDLMILGSERSHPHSLSDETFDALFTADRPIHFNYHGYETELKGLLFGRPRVDRITIGCYMEEGSTTTPFDMMLLNRVSRFHVAKAAVLGGSRRNEKVRIRQQELLTTLEHEIRSARKYIIENHKAAERQPQPTAMSSGHLIAVYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB23</accession>
    <name>D4DB23_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">TRV_04322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021580.1">
        <property type="nucleotide sequence ID" value="XM_003021534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB23"/>
    <dbReference type="GeneID" id="9578541"/>
    <dbReference type="KEGG" id="tve:TRV_04322"/>
    <dbReference type="HOGENOM" id="CLU_016773_0_0_1"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="812" mass="88926" checksum="1ED56D8E8A68DC83" modified="2010-05-18" version="1">MLSCRRRLNQRAQPASPTETLLEFSSKSTSSLTCGPKSDPESHGNVSTELQSNRSARYTRIVLGGKANAENLPVPKTKRRKPGDESYKLVEGMEELAGCSRPCPQSVENGSTAQKTRSKKPRKQTLKGQGSEETTNPRLKGKIIKPSTTSKILTSKRSIMHPADLQQKEAGSPGWESCGLRLEEATIRRDFWTPIKNTTPAHIDLTGSPVFTQTGETQDKGNDFRSLMSGFSFSRETSREIGSDGQYPAEGPTTKQLLEFIPQSLPSGKNLEAEALDTAASSTSEGNSRFKPAGKPKRPAKSKITTITSLTTGRYESPFTSEGGDYISSADKDVESIQPARKPTSKRKATKAKSGTKISKDECQARFRPAPTVEALQTIENQTLLFGTSSQLERDSSPSVYGIESGLEHSQGQGESARVRSRELSSGLGVSRFSKSKNLWAASSRDLDGYLLNVEMVDLVEPAAPAYQPQDEQQSTNKFSQVGIHTEILPPIEHESSEKTEPSIHTVVNIDTSDTIKSPHEISTTHDNENGVASIPDFNRLSTDALTAKVASFGFRPIKSREKMIVLLGKCWESKRKAAGRPEIGPSERDEPQGTSQGRPLNNTTNPIEAGPIPSVIPSIRTTTPDGIVDSSRTIETISHNLKLPPKAKGNTLRSKGTERDTQPNTIEIDDSTDEGLPESSKQLTSSGNSHLPPRVSSCDKPSGLVPGPGAFSIRTKGVSTKENEPAELPNIFLQITNAVKAQPRIRSIKGIKQPTWHEKIVMYDPIWLDDFTLWLNVEGFKRIHEDREVHASLVREWCESKGICCCFKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC65</accession>
    <name>D4DC65_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 transcription factor GliZ-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000237">
        <property type="protein sequence ID" value="EFE40551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021169.1">
        <property type="nucleotide sequence ID" value="XM_003021123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC65"/>
    <dbReference type="GeneID" id="9578012"/>
    <dbReference type="KEGG" id="tve:TRV_04717"/>
    <dbReference type="HOGENOM" id="CLU_052542_1_0_1"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="31956" checksum="AEEE812936EA4901" modified="2010-05-18" version="1">MSKGPLSPLVTNTNPELKSTGMHDEGLSSLHDLDGWTVDLRSIIDTSGGRRSEGLEGLATPISSGKAESFTDNGTEPNSPTTPEIQSHHPSAYRPPRDTCTCVQAQATNIAVLHKLANRDISDRFDLAMKSVTSTLDTCERFIACGTCDKSFPLILLTFSAIELIFKLFELLAINNSSMLPPGESHILACCLGDYKVSKEEGKAIQNVLLKMILSKGKQTLDALHNLVNDSSEPSEPNHASFVQRDGSKLEIPDTITRNTQRKLSIVDQDYMNQCIKRKKEEVEALMITVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCC1</accession>
    <name>D4DCC1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021101.1">
        <property type="nucleotide sequence ID" value="XM_003021055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCC1"/>
    <dbReference type="GeneID" id="9577962"/>
    <dbReference type="KEGG" id="tve:TRV_04774"/>
    <dbReference type="HOGENOM" id="CLU_049186_0_0_1"/>
    <dbReference type="OrthoDB" id="5352953at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="39372" checksum="511496E9D018C562" modified="2010-05-18" version="1">MEFKFDFPIASSPVPSSSFSQLTSVSFGEAEDLDRQCRERFQKYVPVNAQDDVVRLLAAFMDHLPKDGSVRLMQDIIALDGDSKLRQLRNHLVDAVLKSMQAPGGKTPAPTPSPCVDTQVQIESLVVTSMNPSSRSEQSILKKDCLKRDGYRCQATGLWDDRSVERGLIIPNDHKALTTTETAHILPFSLGKFDGDKAIETENKARIWQCLYRYFPGLHRVLSPETINTPANAITLDHSLHPQFGSFNLTFKETDDAHVYKIIKHTQANHIAFFFLPSNGLMALRCEDSSVLMPSPFLLSVHARVGKILKVSGLKDRLEKIMYTLFLPSEVDPSGSTDLGTIVSNRLLILTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE0</accession>
    <name>D4DCE0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021080.1">
        <property type="nucleotide sequence ID" value="XM_003021034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE0"/>
    <dbReference type="GeneID" id="9577943"/>
    <dbReference type="KEGG" id="tve:TRV_04793"/>
    <dbReference type="HOGENOM" id="CLU_3207937_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="45" mass="5160" checksum="D92610862398F1D3" modified="2010-05-18" version="1">MHDEKASWLYAHDYGCNLAGSGAGWRPSSSTRREEEDNDDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD93</accession>
    <name>D4DD93_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020793.1">
        <property type="nucleotide sequence ID" value="XM_003020747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD93"/>
    <dbReference type="GeneID" id="9577544"/>
    <dbReference type="KEGG" id="tve:TRV_05101"/>
    <dbReference type="HOGENOM" id="CLU_1653418_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18019" checksum="04A614A315E86D5A" modified="2010-05-18" version="1">MDPLSITASVAGLITLAGVIISKGFQISDRFTNTEKELNSLLNEVSSFSGLLVGVQSHFEQHQASTPFSIYSLNLPRLSERDQSPTTPAGHLYTALNDCKSILEDVKRLVEKISITPSFQLVLRREVFLKEAVKHAAKLERYKSFFILAFQINSWYERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD95</accession>
    <name>D4DD95_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Lysophospholipase</fullName>
            <ecNumber evidence="2 8">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 8"/>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020795.1">
        <property type="nucleotide sequence ID" value="XM_003020749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD95"/>
    <dbReference type="GeneID" id="9577546"/>
    <dbReference type="KEGG" id="tve:TRV_05103"/>
    <dbReference type="HOGENOM" id="CLU_013227_1_0_1"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="9">
        <location>
            <begin position="163"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="786" mass="86001" checksum="C725E6D55D437469" modified="2010-05-18" version="1">MGAARFLQARWRQALKGALFVSGSASIALLGKQSVRCDAGRSTAVWNAKKTPQTPEESALDKLVKSGIQSGEKENKDDADAGGDAEPKSAWETMTDRLGTAEGYFSSSDWSADWSAVFKDYISPGWTFFSPDILRNLQRELSMAPGSVADDVWKEACDPSFNPSIVEEASVRIGGTLCSEEEAFLSDRRKVVARNLASYLGLPEDEVHPDDVPVIAMCASGGGLRALIAGTGSYMAAKEAGLWDCLTYTAGVSGSCWLQTLFNSSIGGQDFGKMIDHLKARLHTHIAFPPEALDILTTPPTNKYLLRGVIEKLKGDPKADFGLVDVYGILLAARLMVPQDTAALNDSDLQLSSQRAVVKGGANPMPIYTAVRHEIPKPSKPGASEDELEEISKRESWFQWFEFTPYELFCEEFAAGIPTWAVGRNFKNGKGIAAAHGYAVPELRVPALMGVWGSAFCATLAHYYREIRPAFMGLAGFSSIDALIEGKSEDLTRVHPIDPATVPNFVLGMEGKLPDSCPDSVFQDSHLRLMDAGMSNNLPIYPLLRPGRNVDLIVAFDVSADSKEANWLSVVDGYAHQRGIKGWPIGAGWPKSNASPEETADIIAEEAQLTKEEADKKVAAAQKASKERTPDSRGNDPDLTFCNIWLGTTEERISSAEPPPSKRLFHEAALNEKDSEFQLTQPHAGIAVAYFPLLPNPACLALPDPDKDEPDAERKILDPLEEDYLSTWNFIYTAEQIDSAVHLAKCNFSEGEDQLKRVVRGIYERKKRERLQREKDTARTSASYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD97</accession>
    <name>D4DD97_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020797.1">
        <property type="nucleotide sequence ID" value="XM_003020751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD97"/>
    <dbReference type="GeneID" id="9577548"/>
    <dbReference type="KEGG" id="tve:TRV_05105"/>
    <dbReference type="HOGENOM" id="CLU_020105_4_2_1"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="53065" checksum="E6F40AECA40BD983" modified="2010-05-18" version="1">MYHTYIWINALYAAMYTNILNYIAVIATSGPSSTYPKRAYRNPTEDLVRFLDSKHGEDWSIFEFRAEGTGYPDDEVYGRIHHFPWPDHHPPPFGLIPSLMASMRNWINGEGKGKRVAVVHCKAGKGRSGTVACSYLISEQGWSAEDAMKQFTERRMRAGFGAGVSIPSQVRWVNYVERWKNVFSKIYVERPVEIVEIHIWGLRKGLKIDVEGFVDEGRKMKRFHRFGKDEFFYQNGGSVPQDTSSSGEEEQDKGADKPDVSSSNASSTPVQSARELTEPEPVTEAAWSALASAPADSTDNVVLRPKNPVIVPTSDVNIDFERRAVVSYTDWSMITSVGHVWFNAYFEGGHDHDSGVFEIDWEAMDGIKGTSRKGIRSLERLKVVWRYHKPAKEEESPSVGKEPEAQVPGAPPPGKVISEPGPGEEVPEGRAADWRGQEEDVEGGEERELLEPRRQQEGEKKESDSTAAQSTPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDJ2</accession>
    <name>D4DDJ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020677.1">
        <property type="nucleotide sequence ID" value="XM_003020631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDJ2"/>
    <dbReference type="GeneID" id="9577376"/>
    <dbReference type="KEGG" id="tve:TRV_05203"/>
    <dbReference type="HOGENOM" id="CLU_024513_1_1_1"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="28796" checksum="7F87DD26ADC5179C" modified="2010-05-18" version="1">MAEVQRIADRIVSPGTPRDPNFTKFAFSDFVAKSFSFALASDVPVCKAYREGHCPLGPLCAERHPTPSRISTSSSPAIAPSSTHGSLVCKHYLKGLCKKGLKCEYLHEYNLRRMPECQSFSRNGFCPNGDDCLYQHLSGDAKLPQCEHYDQGFCPLGPICAKRHVRRKLCRFYLAGFCPAGKTCTEGAHPRWSENLPKPTVRVEKTQEEIESERARIREEQEREEEREREWRRENRGRDGRYPRGRYRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDU6</accession>
    <name>D4DDU6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020588.1">
        <property type="nucleotide sequence ID" value="XM_003020542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDU6"/>
    <dbReference type="GeneID" id="9577287"/>
    <dbReference type="KEGG" id="tve:TRV_05310"/>
    <dbReference type="HOGENOM" id="CLU_287609_0_0_1"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="774"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117541" checksum="73D0FCAA7F52D808" modified="2010-05-18" version="1">MFNRPHPTKMQYMSLRPIPLALGDKHTTFDKGGGGSSGETTLDEVEVAEREARAQTSRLIAKRRLVTVVKHVPSSKEQALPVLINQINCSFEMDRLLQSNIGLIGTRPKRALSVSQRVVESATTAWGVVLWGITYVVMVWIYPIITKGFIACLIGHRVIAEVVLRILEWRAAPDAAALKDISATAQQIDIRLQQFCYWPIQYLTLRKRKDDWESVTNSHPDYIRFYNSLWLVANDVIIGIALGSYIVDNADNVASEINAVLTGWTVDGLQQTISWLMGWPAGLKLNNELAVFLGDLFLWVIAHWASKKNPLLYLLVDVLRPAVHLHGAHLQLLHSVSPDLQLAADDHHLAVPSLPRPQAQHPAQPHRLLRLRPGPTAAGDDPVHPAVLPAADGAGVLHHLCVCEDGHYLPEGRAGHLSGLSQPFPLVCTDAAPQGLSTTPWYALLLLSLCGGTRFELRRPSLPPPPNDQLEYTETSYIHLKSVPLSLREMFDQYFRLGQRIRQHYLSPRVILCLATGQFVPPIHRRNLYSLQYSMLPAQRVGIVDVWSRLTAKSSTGPGSGGGSGPAGSSSGAPLSFPRGDSPPSPLSPFSSQHLHPLTIPSPSLCYPLHHPLHCYLHHPLHCLLPLSCMTKNPSLVVLPRRRPPSLPSSSFRIASSGYKIPSSSSVVDASFCLLSLSFLPYPPSWLQSAEKSSADAARRQAKAKASLYKDRRRPSTSPSFFLFFLLSSLLFFFLSFCSTTSRCITSDTRQRRETALSFLLVTYPKEREARLRQTSKMHGKWTDEEDFAIVALRLGTNLSWEGIKAKFDAAFPPANCKDLESRWNKTLRPTLSPGLGNRIACAFDDYRHYRPRHIEDGEQRRLVLGVLRALADHPAERIVPPHPEELESSGEIQPAAAAPALQPSGSATQLSAPPQQPPAPEQQQQQPTDPAQGTGASGQQQHGSGPTSTTAPDSPLFVPQDDNNVDVADSADNTTAADASAANTTTTTTEEAGANSTVAVDTQTYPQSLLQQRVEQSPPDQPMLEINAAVPPPPPSPTPQQQQQTPQQPSSDLGPVVVDPNIDPQLYGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDV0</accession>
    <name>D4DDV0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020592.1">
        <property type="nucleotide sequence ID" value="XM_003020546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDV0"/>
    <dbReference type="GeneID" id="9577291"/>
    <dbReference type="KEGG" id="tve:TRV_05314"/>
    <dbReference type="HOGENOM" id="CLU_008830_0_0_1"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="648"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="761" mass="82131" checksum="F05AA74D2A84F7F7" modified="2010-05-18" version="1">MTVPEQQQQQREQREQRKEPSPGPATSVPTLNGQPNGQPLAGQNGIASHTELASNHGTNDVTVTEQHRHQQQQQPQSAVHYAHSHTSSVSPHNTNTQPAAASTPNRTSVVSREGSSTHSSNFDEMQHPESDGDHYQTDNEIEMGGTGDAGPSGTGPAGTSGAATTNSITAAANAVTAAAVAAVAATANAAGGPPSKKKKGQRFYCTEFPPCNLNFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNENIPCDSLAASGTRFQRQVRTDRVRHNGRARAGTAGSHSHSHSRNLSTSSISSNMSSYAPQHQELRRRPQPLMMAGSGAEHHHHTRSRHSLSLETRAEPPKTPPNQSSAPGPTFTPSSATYDQSSPYYASPSSAYGSSHWPDRNVGRRLSVPTSTRPFDPSHQNYPSQPPYTRMTHPPYPSQSIAPAPPPVMAPAPTDPAQYAAVTPTSAIDSGFEADPRRRTWHPSSYTGFSRPPQATSGLWYQQSAEAPGATPGGNVNVPPLSSPSQPTTTRLPGIESFDHVPPRLEYNREREVSPRSYDRHHYQPQPYSQPPPPPSHLMGSTPFAPTFNAGPRPAPPFSGAEHRRGQLSLDTTLQRTLTRLDLHGNSSSGGSAKDATSWSQATMGELQSIGSRPSTGAGTGPLKEDEDEMEADEGPGPSVPTETSPTHHQPAQYEMNAADHHSHNVHQLLLQQQQEQQHQQLLPTRPSGGVGLGRLQALVDIATSETEQAKYKPDDPAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY9</accession>
    <name>D4DDY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000279">
        <property type="protein sequence ID" value="EFE39936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020554.1">
        <property type="nucleotide sequence ID" value="XM_003020508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY9"/>
    <dbReference type="GeneID" id="9577253"/>
    <dbReference type="KEGG" id="tve:TRV_05353"/>
    <dbReference type="HOGENOM" id="CLU_2122854_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="114" mass="13259" checksum="76C64EEC910FD609" modified="2010-05-18" version="1">MLSLRKHNPIHLPLSLSLSVAFSSLMQPCFSFPWSFGFSFLQNTLHKKQIRVAKRTKAKKKKEGQEEIEGGEGEAQQEIISWCLDGPRGRNGRTDQTRRRDEMRRDETRDGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE63</accession>
    <name>D4DE63_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020463.1">
        <property type="nucleotide sequence ID" value="XM_003020417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE63"/>
    <dbReference type="GeneID" id="9584202"/>
    <dbReference type="KEGG" id="tve:TRV_05429"/>
    <dbReference type="HOGENOM" id="CLU_015869_2_0_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="443" mass="47349" checksum="D14A651E7E4E2764" modified="2010-05-18" version="1">MIDLGLARISRLVPASSLAWKAIHVAGTNGKGSIAGYLSSLLTAGGLRCGSFTSPHLVDRWDCITINERAVQESLFRHVEEQVKRRDASLGIGATEFELLTATAFEIFRQEDVDVGVVEVGMGGRLDSTNILTSESVLVSVIANIGLDHQAILGSTLAEIAAEKAGIMKPGVPCVVDGTNEEQVKSVIRHHASRANTTATFVEPDSIVSAYPQLRQRFHDLAAQPHQRSNISCAVAALEHALPRLRANLKPTDLLPFLPLNPRAGRLQLVDLWPLIPRRDSPVLLDGAHNPQSAKVLASYVDQTLRRPEANITWVIAASQGKDLPELFGSLLRPGDNVAAVQFGPVDGMPWVRSVPTAELLATARSITTGSSRGTTTQFGHDIPKALQWAHLTAADNPVVIAGSLYLVSDILRLLRQTTAAEAEEAEAATAADTAVARTAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEP5</accession>
    <name>D4DEP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000304">
        <property type="protein sequence ID" value="EFE39685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020303.1">
        <property type="nucleotide sequence ID" value="XM_003020257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEP5"/>
    <dbReference type="GeneID" id="9584041"/>
    <dbReference type="KEGG" id="tve:TRV_05615"/>
    <dbReference type="HOGENOM" id="CLU_035537_0_0_1"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="329"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="538" mass="58292" checksum="C60CA6C8C045A48E" modified="2010-05-18" version="1">MAPGKSKKSKKASAVPLQPPPPPPPPVSGSSLDFSYAIPEAEPAPDHHGYSIFNEALDAPYEEDKEFAAASSSAAARRRAASRASEPAVALPAAAAPIPTTSSIPATSIPSSIPAPAPISTSAAPIEPAAAVFSYLDHPLDEQMQMKPPSSHSRKASEPVLPGAPRPKDHTRKASLSQLLRTVSGGSSSTAKDKEKDKERDLSPSRSSSASKESEYQPITPPDMLFDPINLNIPGTKGMSKSHMAGSYMTDLESLLEGPTSAAPAFMSFSHPESFYMPKSMLSYSMAPPPPTKQQQQLQHSDRAPATEASRRRSQASLPEQFEWTATPETPHHVYRKFERLNHRVLRHLQEEIAQLEDDLLTIDDIEAARAGASGSRASSRQKQLAAKYRDQIQDHSVLQNKRTDLLDKIILKTDQYMIKNLPAASDDDIDAYRTFLRSPAGASTKSERKLLDQRSDLVTMAPRPASALHSNPLYSTVAAIFAAILFPLLAFGAITEFFGRIVVVSFVAGSFAWWASNGPPGHDYLIEPQDGWKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DER6</accession>
    <name>D4DER6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000307">
        <property type="protein sequence ID" value="EFE39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020277.1">
        <property type="nucleotide sequence ID" value="XM_003020231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DER6"/>
    <dbReference type="GeneID" id="9584015"/>
    <dbReference type="KEGG" id="tve:TRV_05656"/>
    <dbReference type="HOGENOM" id="CLU_042165_0_0_1"/>
    <dbReference type="OrthoDB" id="4158501at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="428" mass="49421" checksum="96D9B2657DD03A85" modified="2010-05-18" version="1">MEFLQPVRYIPGSNEAEFCGPQTFEDSKSERQGRAVMAYSKVYGVAKMISEILKAFGSELDDTPTDIKFHIARMEKELTQPYSAKLLAAVEDLFYILLARVKSEIRQIDIEESFEFDYRFARTNSRLLRSKGLPEIKHLRLIFEACKCLLLSEEVCGVLNTELIRHQEEDYIQQTMLMGEEAGYFADDPVSYRQYIQSLITDPDSPYRMKWSGLNPVYDASPEMIFATLREKYMGITAREKKQGKCADVKVRSPPPAWKSNPAYAEERRIQANREAACAMLHGITVGEFRRQNSQEVVRLYVQQNLCVCLENCTCSRRCTAKGWRICPCTSRMNLLYEEDLGLRRPFVEKCADMAVILFEALSASYQGIGLHGMTCFLSRGLEFFHDEVTHFRDHYWRAVAQDSYCFDFNMDFQYPQGIRDGVHRGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF01</accession>
    <name>D4DF01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000318">
        <property type="protein sequence ID" value="EFE39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020191.1">
        <property type="nucleotide sequence ID" value="XM_003020145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF01"/>
    <dbReference type="GeneID" id="9583961"/>
    <dbReference type="KEGG" id="tve:TRV_05742"/>
    <dbReference type="HOGENOM" id="CLU_084522_3_0_1"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="175" mass="19346" checksum="C501D3F76BE88D44" modified="2010-05-18" version="1">MVRPLKELQVTERLIPAWGNFPNTSIQEKPLLIYQSVFDSASPDAVREHLEAVGAVVPQWTYSMYPANHFHSKTHEVLSVVAGQARLCFGHEENPDRFETTVSKGDVIVVPAGVTHCLLADAQGDFAMVGAYPPGKQWDLCYGEEEVDKQASVIRSVGWFDRDPIYGDSGPVFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF32</accession>
    <name>D4DF32_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Forkhead transcription factor Fkh1/2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000328">
        <property type="protein sequence ID" value="EFE39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020159.1">
        <property type="nucleotide sequence ID" value="XM_003020113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF32"/>
    <dbReference type="GeneID" id="9583928"/>
    <dbReference type="KEGG" id="tve:TRV_05777"/>
    <dbReference type="HOGENOM" id="CLU_007090_1_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="344"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="344"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="78409" checksum="FBBD2CA1EA1A333C" modified="2010-05-18" version="1">MQVEHTSQPDFERTVEPAASADENDDEHDNEMAANQDLVDSVIANLAVAREPVAVMTLHSNARTQQENKESVEAYAKIAGRDWTYYVKTLHVNIGRPPDRDQRLDAQSSPITVAAQALPDVHIDLGPGKFVSRLHAEIYYDRDDPPCWRVRVNGRNGVRVNNTFYKRGTATQISCGDILEIANTQMMFVTPRDKAVIDPAFIQQAQNGVHTTRETDETAWDGSYHSHPTTANAGTSSSAGAGAGAPRRMSFALNSREPADTASVSAAAANSTGGAATANGSRRAAEIANAATVTPKRQTTPSQRPLSRDTIEPSSKVSPMYNRGLMMESTEEIDYSEDAAKDIKPPFSYANMIAQAIFSTEEEKLSLSNIYKFIMQKYAFYRHSQSGWQNSIRHNLSLNKAFQKVPRRTDEPGKGMKWQIVPEHREEYWKKQAKRSGQSSTPASPIGKERGGNSAYQPINGHVATNVEKNIDASAAALAARPSPQANTTASPGYHSFSVAPIEAYTPDRGSRNGLGINGAGTHDFDEQSPLPNGPRNNAPTRPYGLSDNAVASPPVLSSSYYDDAASSMITPAPLRQQPRLAPPSTAQVPSRYMQLSSPAQFWKLADTGNTPARPMPDISPLKPSIGTSESSRWKTLNPIPSSSPPPANLGSPTKPPTSSLRGRGGVSPLGRDVRERESSTIKRHQDSWDEDDDDNDGDDTGFDLARFVPLPSNAICEPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF88</accession>
    <name>D4DF88_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020061.1">
        <property type="nucleotide sequence ID" value="XM_003020015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF88"/>
    <dbReference type="GeneID" id="9583825"/>
    <dbReference type="KEGG" id="tve:TRV_05834"/>
    <dbReference type="HOGENOM" id="CLU_2759627_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="70" mass="7960" checksum="4051A62989DE3D22" modified="2010-05-18" version="1">MIVPENLKGSHDNVFTFPAPALDLAFDDGLIDQVKQVWKAIMGDEVDENNFLKFDDREGMIDEEEANETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF94</accession>
    <name>D4DF94_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020067.1">
        <property type="nucleotide sequence ID" value="XM_003020021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF94"/>
    <dbReference type="GeneID" id="9583831"/>
    <dbReference type="KEGG" id="tve:TRV_05840"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000061">
        <property type="entry name" value="Metalloreductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="48871" checksum="E9C68CCC8E16A97D" modified="2010-05-18" version="1">MYELFVTLHIPISLIFIAMMFWHCNNFLTSWHYLISSLALWGVSYLARVFYLNWLNPFRLSFLIGEESAVTILPDNAVKVTIPTQMKWRPGQYVYLRMPGISMLQNHPFTIASLCSDDFPSSYGSKYRDMTLVFRPFDGPYGGVRRELSSFDDVVFFAGGSGITAIASQLLDLIKRMRDGKARTRTVKVVWALKRPDTMDWFKEELRICRECAPPNSMFCNFYLTGAKRYDKNAEVVSHPRPQSGDFHDKLNDVFQGVASKRNSAYIREEAGGDEDKERELRRENEDSISALPNAHLAARPRIQTGHINPYFPETPNSMMSSPEENDGPNFGFPSTPTMLQKNLMRFAFFPRQKRDGWKTEYGRPDIPFMLKQFSKEFGRRTCVFVCGPPSMRVDVANTVAKLQTTVMNDPNKDELFLHTENYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFB7</accession>
    <name>D4DFB7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020090.1">
        <property type="nucleotide sequence ID" value="XM_003020044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFB7"/>
    <dbReference type="GeneID" id="9583854"/>
    <dbReference type="KEGG" id="tve:TRV_05863"/>
    <dbReference type="HOGENOM" id="CLU_060131_6_3_1"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="24703" checksum="CD777D0FF6B815F6" modified="2010-05-18" version="1">MSTLSDVPGLILEQAQESDAQHIVDIHIKAFSSNLMLLAQFPTATAQEGLKTFLIDLIIQEIRDPGYAVFVVRDAQGCLVSFARWCLPRYTPDPHREAPSQLPEGTDMEVLNAWSARVLDVTRKVIGDTPHYHMTFIATDPKYEHRGAATLLMRQALEQCTKETVPLILEGTLNAIPFYMRLGLVDEGSISMDLEGIESKHGPSLYEERLFVFRPRHAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFI8</accession>
    <name>D4DFI8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leukotriene A4 hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05938</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019970.1">
        <property type="nucleotide sequence ID" value="XM_003019924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFI8"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="GeneID" id="9584723"/>
    <dbReference type="KEGG" id="tve:TRV_05938"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="367"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="460"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="679"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113115" checksum="A2B3A67CBE8EF084" modified="2010-05-18" version="1">MVMVVALALRCGGRAGRSVAAAKHGVRRHAARPASYFSSAALPLSSASSLSPRPLLISSPSPSPSSSFSSSFSTSSSSSPARSLASLSTVRPAAARKSAGLAIPLQKRSCSAEFRTMNPSDRETLPDVAKPSHYHVSLYDLTIGGNWGYKGTVKIDTKITRPTKEIVVNVKAIDVQLAEISAKDGSAASKATEISYDRKSERAIFKFDSELQPADMLLTISFTGTINNYMAGFCRAGYQSAATPGPATPKVGEQHYMLSTQFESCDARQAFPCFDEPNLKATFDFEIEITKGLTALSNMPVKSKREGSKPDLEFVSFERTPIMSTYLLAWAVGDFEYVETMTKRKYNGASIPVRVYTTRGLKEQAQFALECASQTLDYFSDVFEIDYPLPKSDLLAVHEFAMGAMENWGLVTYRTTAVLFEEGKSDEKYRNRVAYVVAHGMLSTPFPRTPYPHLTNQYIELAHQWFGNLVTMDWWNELWLNEGFATWVGWLAVDHFHPEWNVWSQFVTESVQQAMKLDSLRASHAIEVPVRNALEVDQIFDHISYLKGSSVIRMLSSHLGQEVFLKGVAKYLKAHKYGNATTNDLWSALSEVSGKDVTSFMDPWIRKIGFPVVNVTEQTNQINVDQRRFLASGDVKPEEDETMWWIPLGIKSGPKAESANVRNLTKKSDSVADINCNEFYKVNKDQCGFYHTNYPQDRLVKFGDSRNLLSSEDRIGLIGDAASLAVSGEGSTVSLLALVEKFQDEADCLVWAQIMTSLGNLRSIFGTHETISKGLKAYTCKLVTPAAEKIGWEFKDCDDFLTKQLRQILITAAGRSGHEGTVAEAKRRFKAWADGDKSAIHTNLRSAVFSINMGEGGRPEYDLLVKEYETNTTIDGKEICLGALSRATDPELIKEFLEFLFSPKVSGQDVHTGGSGLAANPKGRYLMWDFIKANWNRIEEKLGANKVLLQRFLRLSLIKYADKEVEQDITKFFSDKDQEGYDRALVIAADTIKSNASYREREEKAILEWLTQRGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFY3</accession>
    <name>D4DFY3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019888.1">
        <property type="nucleotide sequence ID" value="XM_003019842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFY3"/>
    <dbReference type="GeneID" id="9584639"/>
    <dbReference type="KEGG" id="tve:TRV_06086"/>
    <dbReference type="HOGENOM" id="CLU_144283_0_0_1"/>
    <dbReference type="OrthoDB" id="5216128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="137" mass="14177" checksum="35B262199D71BD7F" modified="2010-05-18" version="1">MAISNSLPVLVVANLFAAMCVGFGINAILRPEHGVSFFELAPPTVDGPEKTLFNSLMAVYGARDVFMGVAIWAATLTGERKALGWILLGVSAVAFADGAICAVNGAGEWNHWGYAPVVMVVGLLALGVLDGSKAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGE6</accession>
    <name>D4DGE6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000353">
        <property type="protein sequence ID" value="EFE39079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019724.1">
        <property type="nucleotide sequence ID" value="XM_003019678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGE6"/>
    <dbReference type="GeneID" id="9583622"/>
    <dbReference type="KEGG" id="tve:TRV_06249"/>
    <dbReference type="HOGENOM" id="CLU_3260848_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="42" mass="5061" checksum="240EDC250DEDBBE3" modified="2010-05-18" version="1">MLEEKMEKKMFGEGEEVAGMQMQTSRDRDMHRKRQTEGKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGE7</accession>
    <name>D4DGE7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000353">
        <property type="protein sequence ID" value="EFE39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019725.1">
        <property type="nucleotide sequence ID" value="XM_003019679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGE7"/>
    <dbReference type="GeneID" id="9583623"/>
    <dbReference type="KEGG" id="tve:TRV_06250"/>
    <dbReference type="HOGENOM" id="CLU_3260849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="42" mass="4904" checksum="554802A6C3DA2E36" modified="2010-05-18" version="1">MRSEKKKKKKKKKSPSSRLDSLACPSSCSFSPTKRREEKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGG7</accession>
    <name>D4DGG7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cap binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000356">
        <property type="protein sequence ID" value="EFE39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019700.1">
        <property type="nucleotide sequence ID" value="XM_003019654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGG7"/>
    <dbReference type="GeneID" id="9583599"/>
    <dbReference type="KEGG" id="tve:TRV_06271"/>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="270"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="478"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="87523" checksum="F3D057ACBAAE1B75" modified="2010-05-18" version="1">MIAENYSDESMKVAFEDLVLQMILEQPLKIPFIAAVILVLNTLKPEATAPIISNIGEQAALYVGQGHWRNAKLMLRFLGCLQGLFEGDGIFPVLEELFSRAVDLQTGSSEDSLGLELVSVILYTIPYVMASSATGFEPQASALLEKTDIIASTPHTLEAIVDPFPKKQGEDEGGRLSSLGLLQKQLQGEAAQSWKLTCIPRPWKEPLTQKEPKEDGNGEEKKENEETPKTITKHAFPTIAVPNPVKTGPRAIFPEIYFSVYTHQDIDTVPPTSDIASSLVRDALVDTINVLDFNRNATAKFLIDVDCYFAPDTFVKRAVPLDQLRDSPSPQKSTWKPEDVAVDAAFSQLLRLPFPEHKLVYYHSVLTESCKIAPAAVAPSLGRAIRFMYRNIDKLDLSLAYRFLDWFSHHLSNFGFTWKWTEWVADLELPDVHPKKAFIIGAIDKEIRLSFAQRIKGTLPEPYHELITEGKEKDTPDFKFSQETTPYSKEGQELMKLIRQKSSDEEIEAVITSIEEQAKTHGLTDPLIASTDVYMTSICYVGSKSLSHFLSCIERCKDRLLAIGPKSDAARRQIINSVMEYWVDQPGIGINIIDKLLNYTILTPLSVLEWALVDNLAAGSTLAKPHIFEMISATMRKVTNRMRQIVAARTQPTLYEPQLSILDETLKKEKADMLSMFQLIEDTLVPVAGGYSDGMMERTEDDSLQPENVMIQQWGSRWLNVFRRKVAVERAFIDEAMASAPALGTMAPPAPPLGIDEKTEESKTLEEPAMDVEEMHDTAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH60</accession>
    <name>D4DH60_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019435.1">
        <property type="nucleotide sequence ID" value="XM_003019389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH60"/>
    <dbReference type="GeneID" id="9577885"/>
    <dbReference type="KEGG" id="tve:TRV_06515"/>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="31873" checksum="6E7CDAB7AAFF4442" modified="2010-05-18" version="1">MANFASSKQELLNIHNAFYQGQYQEVVDFDTSSFSSENTLAARVLKLRAQIALGQSNEVLKSLGAKRDTPELDAVAALAEHVSGNEEEALKLAEDLAAKHEDNAAVQVLAGQVLHAQDKTAEALALLSKHSGNLEAVALIVQIHLQQNRSDLALKEVQAARRWAQDSLLVNLAESWVGMRVGGEKYQAAFYVYEELASVPSTTSALSIVGQAVSELHLGRIPEAEAALQSALQKYPEDPQVLANSIVLNAISGKDKEELTERLSKVQPDHAFLTDLKEKSDLFDTAAAKYSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH94</accession>
    <name>D4DH94_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000375">
        <property type="protein sequence ID" value="EFE38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019418.1">
        <property type="nucleotide sequence ID" value="XM_003019372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH94"/>
    <dbReference type="GeneID" id="9580134"/>
    <dbReference type="KEGG" id="tve:TRV_06549"/>
    <dbReference type="HOGENOM" id="CLU_2122855_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="114" mass="12965" checksum="9C287F1CAC4DC2D2" modified="2010-05-18" version="1">MPGREMEKAALQDPFSSSVATSVRTASYHSQPSDRQPGRRQQFKSYRLNGEYERPWLGDSRLKRSRVGSYIIWGFIGLGLALSAYINFTVTQKVSKHQAGYIHTYMFITCLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHM1</accession>
    <name>D4DHM1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019273.1">
        <property type="nucleotide sequence ID" value="XM_003019227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHM1"/>
    <dbReference type="GeneID" id="9577514"/>
    <dbReference type="KEGG" id="tve:TRV_06677"/>
    <dbReference type="HOGENOM" id="CLU_018687_4_0_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="199"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="51246" checksum="78411FBF370ABA3C" modified="2010-05-18" version="1">MLKVRDANRGKPAKRTSSSQHPYTSFLSQGSGGLVPDIDDDDDGDEIGYEDDEDEFGLPSVTNMRRQRAKPSPGYSLPVKTTQSTPEPSSHVNASNLIPSMHRMRLRANSTDIAEERSNLTYPTANKSEGKILRPQYKDILKDPANSLNLINHSPPPPGASAKETEAHSTRISRVNKFKRILQSSTVSLPELRDLAWSGIPEEVRAMTWQLLLGYLPANSDRRVSTLERKRKEYLDGVRQAFERNSSIGSKAVPATSSTPNLGGGRGIDEAIWHQISIDIPRTNPHIPLYAYEATQRSLERILYVWAIRHPASGYVQGINDLVTPFWQVFLGSYITDSDIEQGMDPGQLPQPVINAVEADSFWCLTKLLDGIQDNYIYAQPGIHRQVNALHDLTRRIDLALTKHLENEGVEFMQFSFRWMNCLLMREISIKNTIRMWDTYMVAYPRKALDPKGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU6</accession>
    <name>D4DHU6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019204.1">
        <property type="nucleotide sequence ID" value="XM_003019158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU6"/>
    <dbReference type="GeneID" id="9577201"/>
    <dbReference type="KEGG" id="tve:TRV_06753"/>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="485" mass="56333" checksum="2499682A4416BC1C" modified="2010-05-18" version="1">MLLEDQRFIHEDLERLEQGISDRVAEEPRNEQSQRLLDIYEDANGLRAKEIQSLTVGDPMDEFYKHLEEIKDFHRRYPNEPVENLEKAYRQGSGENDAAIQEIENMFTGEESLGQFFDLTKLHELYLNLPGVKRLTYLQYLDLFDTFTQPELPVKRANKLTDQYFNYVGELAAYLEGFIKRSNPLEPLDELFASFDTEFAELWEAKKLPGWTEESQSKNGTGPKTEGTGEGIWCADCEKEFTNENVYKNHLKGKKHIRAAEAKKANGDSETQQSQSEKSKDALVRVLKERAVAEREHRISSLAKALKEERQATRVNVERKQGMTERERQMELDALFADTGDKGPGKRRDSESESDNDEKVYNPLKLPLAWDGKPIPYWLYKLHGLGVEFSCEICGNFVYMGRRAFDKHFSEARHIYGLRCLGITQQTSLFREITKIDEALRLWETLEKERKHERDIKENVVQMEDAEGNVMPERIYLDLQKQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIS8</accession>
    <name>D4DIS8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000412">
        <property type="protein sequence ID" value="EFE38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018897.1">
        <property type="nucleotide sequence ID" value="XM_003018851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIS8"/>
    <dbReference type="GeneID" id="9580068"/>
    <dbReference type="KEGG" id="tve:TRV_07089"/>
    <dbReference type="HOGENOM" id="CLU_816290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="340" mass="38605" checksum="158C34173B0576F8" modified="2010-05-18" version="1">MADFSSMSIESFAELSRLIVEVSKTYFTYLPIEPPPDILAKIPSDIPQFLDNTPASRELRAAYVQHVISKTLTYRIFQPFLFTLGRRYDKADTFFQMLSIDIRRKSVRREAFWRQQTLKAAYTTSDAKQAINVVAAVIVDEIVDHIRHFTDPTHLDALLTNVRKIVKLAAETWRLARVERELITATMPSAEDEQTANEEWEEFDYESNAPLPGGEGAAEPPLMPKKFRRPLLRMLPRIFRGAVHEDFLTEDDHEKASPCTYLRGVILYSDSPSVLARRAEMFKKKPEAVGVIDDAEDARLRAASATPPNASGRSPSPKSPLGNRSPRSRRSRERAFGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU9</accession>
    <name>D4DIU9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018884.1">
        <property type="nucleotide sequence ID" value="XM_003018838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIU9"/>
    <dbReference type="GeneID" id="9580056"/>
    <dbReference type="KEGG" id="tve:TRV_07110"/>
    <dbReference type="HOGENOM" id="CLU_060351_0_0_1"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="30080" checksum="3631EAA75D2B6157" modified="2010-05-18" version="1">MAVSTANISTRVSLRWPPEPSYETTDTASLSVGGWYVDLRIHRESGKVEWAMAGQRVVESASPSIVVFTHAIDSLQLFDTADIGTFKKLSNGDDLETGKMIRHDLPGAPVCEYEELWRSLDIPKTVPKGHGYAWVLESEEMLPNISMLKQEYEGVKVVKTFLGRVPGHYIALRQTQWYQEKQVDGKPVLTKAGGEVSGRREIWDATTGQNAAVKYAVGAECDNLPSLVAAGESLQFSGEGEGPWRSPGRVVIVDGTRFLVRAFEELPITINGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI8</accession>
    <name>D4DJI8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein Rnp24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018666.1">
        <property type="nucleotide sequence ID" value="XM_003018620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI8"/>
    <dbReference type="GeneID" id="9580819"/>
    <dbReference type="KEGG" id="tve:TRV_07356"/>
    <dbReference type="HOGENOM" id="CLU_027451_1_1_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12396">
        <property type="entry name" value="RRM1_Nop13p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034225">
        <property type="entry name" value="Nop13/Rnp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="199"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="43864" checksum="5632F68F9A64C655" modified="2010-05-18" version="1">MSDSSSSSRTPSPQPSRKRKHVPDEPPLEIDLNAPEPASKKALRKEKKAKIKSSSSGTTVPAVSEGTEKGNETQKPEKNDSNKKQRTGFGVWIGNLPFTATRETLRTFLTSKSGILDSQITRVHIPDSGTKRKGVKQNKGFAYVDFTSQEIVERAIALSEELVGGRRVLIKDATNFDGRVVKEADGDDLKTAGGNPPSTKIFVGNLSFDTTKEHLEEHFSPCGSISNIHVATFEDSGKCKGYAWVEFESTQSSQAAVRGFVKIPDPDDEIEEAEEEVEEEEEEEDGAEGANGAGTKKKPKKRRMKKVWVNRLQGRNLRMEFAEDSTTRYKKRFGKEKTETKEEAGSNNRPASEATQGSVNLKQKSKKPIKSYGQYSTETVQKLSGAIVEAKGTKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJQ1</accession>
    <name>D4DJQ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018574.1">
        <property type="nucleotide sequence ID" value="XM_003018528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJQ1"/>
    <dbReference type="GeneID" id="9584503"/>
    <dbReference type="KEGG" id="tve:TRV_07419"/>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="646" mass="70372" checksum="3C7EB819F2684F88" modified="2010-05-18" version="1">MQMFQSSFLPAWTAIQSISDIFGFHSPAVSRFNPTEATIQSVHKALFANISNPETRLTCREVVTAFLTQIDTYNPRINAIISLDANSLAVADDLDAWLQDSLEDDDGSYTPDNTSSNSWSDITSLMPLYCIPVLLKDNFDTANQSTTAGCAALSGSPPPVHDAPVVKALREAGAVILGKTNMHEMALEGLTVSSLGGQTLNPYDTTRTPGGSSGGTGAAVASSFAVFGLGTDTVNSLRSPASANGLFSLRPTRGLISRAGVLPVSYTQDTVGPIARCVWDLAVSLNVMTAGEWFDERDNMTALRPRHVRGLDYTASLSRYQGENGGESLLGVKFGLIEGFMNRADNSETTPVNKAMDAMVCRLKKAGAIVIPVTDSMYNSTAILGLDVQAYEYREMVDAYLQGLHGEESRSPRTMADLYSEIDNEQDSFLVIPHQYAFVQSALVSSPLNVSYAQKQLAINALTLSVKRTFSSLNLDALIYPQQQNLPVKIGSRNQYGRNGILAALTGNPVVTVPAGYSNRDIFRNIPSGVPIGMEIMGLPWEEERLLSIAARIEALEKIRRPPVLKAKTRNADAGKWIESVPKVVPDRKNIHNMYPLGVYRNHFHGLSVYPKHHIREAAALLPSTIAKEKFPFSSYEQTLSFVQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJT5</accession>
    <name>D4DJT5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018507.1">
        <property type="nucleotide sequence ID" value="XM_003018461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJT5"/>
    <dbReference type="GeneID" id="9584436"/>
    <dbReference type="KEGG" id="tve:TRV_07453"/>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="540" mass="59722" checksum="FCAB8610CB5C9C09" modified="2010-05-18" version="1">MSGVYSKDDVASHSKGDSVWIIIDGDVYDVSKFLDDHPVLQRMGGKDASKQFWKYHNAGVLKKYQPKLKIGSLDSKKAEAAPAPAPAPTPAPKKEAPKPQEQSSPVPAAEALDPYGELIPFSDPSWYHGYYSPFYNESHAALRDEVRQWVETEIEPYCHEWDEAKAVPESIYKQMGERGYLAGLLGLSYNKDLVKNQVKSVSPEKWDLFHELIVTDELSRAGSGGIVWNLIGGFGIGCPPVVKYGSKELVERIVPGILAGDKRICLAITEPDAGSDVSNLSCEAKLTPDGKHYIVNGEKKWITNGIMSDYFTTAVRTGGPGMGGVSVLLIERSAGGVSTRKMDCQGVWSSGTTYVTFEDVKVPVGNLIGKENKGFKVIMTNFNHERMGIIIQCLRFSRVCYEESVKYAHKRRTFGKRLIDHPVIRMKLAHMARQIEASFNWLENLVFQCQNMDEDAAALRLGGAIAGLKAQSTTTFEFCAREASQIFGGLSYSRGGQGGKIERLYRDVRAYAIPGGSEEIMLDLSMRQSLKVHEIFGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK52</accession>
    <name>D4DK52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018419.1">
        <property type="nucleotide sequence ID" value="XM_003018373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK52"/>
    <dbReference type="GeneID" id="9584347"/>
    <dbReference type="KEGG" id="tve:TRV_07573"/>
    <dbReference type="HOGENOM" id="CLU_013364_5_0_1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055631" evidence="3">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="468" mass="51349" checksum="23C65CB6C4F7C485" modified="2010-05-18" version="1">MLLSRTFLSICFFARGLASPVTTSGRNQSEGKISWGPCDINATLPIQCGSLGVPLDYTDSKSNATLNLQLLKVPAINGASKGSILFNFGGPGFGARAKLAGAAKILQTGTETTLTFSCFKDNNERLAAFSNARYEELLSPKERAPLGRLWSTASIFADICDRYPEANQRGKLISTAFTARDLMQIVDALEEDGLLRYWGLSYGTVLGATVAAMFPERIDRMIIDGVVNFHDYYNGYDIEVWADTDKVFSAFLQQCVKSPDECALARPGLTAPRLEESIYKLLDNIKYQPLVFNDTLIDHSVAKNLIRPNLYAPPTWPLLSKALENLRTGNLTGFTENSITLSPPWENGIPTESPFGIPCSEKVTGLNRLDQIQFTIKSLDQKSKLLGQVGIPLAMTCTRWKTKAKERYSGDFKVKTKFPILVIGNTFDPATSFPSAQNASATFDGSVLLEHGGYGVSLLQSSGEYYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK70</accession>
    <name>D4DK70_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018397.1">
        <property type="nucleotide sequence ID" value="XM_003018351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK70"/>
    <dbReference type="GeneID" id="9584315"/>
    <dbReference type="KEGG" id="tve:TRV_07591"/>
    <dbReference type="HOGENOM" id="CLU_394801_0_0_1"/>
    <dbReference type="OrthoDB" id="4173387at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="836" mass="90490" checksum="519ACBEDAA79B77B" modified="2010-05-18" version="1">MPHNSVQSEFEGSRLSIGSQYQHQQQPQQQQQHEQQQQQHSLTIPETIPRVKSLKFDSQPFSVSFMGEVAHIMSNGDEKRPRDSKRYSGRGLALITEERPVSHTLETSEPHVQTDVPNNQPMPLPDQPMQSPGIPEINLPTSTPNIEPVSATASDRGSGESGVVSVLADEKDIEKGRLSFAVSEVDVKPTRESSVISSADTLDDSKQIEAEIIVTNGNQKQNLPADATEQQQGLGLRKFSFELEPEISPPIDSPPLVDHQQGSSTPQTTNWQSEYKFPPPGTVPPPPVTDVSNSLPSNPVHPAHARTWAQTDQRSVSPLPSTHARTDTNGSGISIQAPGAATPRTHNQQTNDRNANYYYSQVGAGCPDPGVYHPPDEQKKRRSSLGFTGIMSKVNLGRSKGQPADRPSSPALKKGSKMFKTLKFDLLHGKNKNNNGPTSEEPAIPTVHTATASHARQFQSVENRDALQRNTPSALSNHNTVNGSVPHLNSGVYDEPSPPMSNRPFSPETVLSPARAFSDDRALSPSRAQSPAPSVNVNQRTPNTSTAEEGPKQTSGNRPTRFYKSVNSVTSRIPGPSNTPPMSRQPSPTKEFSEGPGGRVAGEHTGLFSPTAVPSGSNFVSNNQVIITPPLSQAMYSPTGSEQTTKSPTHSPHAKDLHFRSRSPLSRPPDTADSPSLAPDTQDPAQRLGAFHASVPHTPRVGDQETPWTITLPQDEKHQNPQIPSSTSQYAMSTTTSPGLRHVSSPQPISPPKGSLNGSYSYFETRPTPASNANFTVPSGDASNGSRIPEQTRLVHVASMEPVELPTNDDSSEEIVMSSTSYPGQEWQPAYLGQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKB0</accession>
    <name>D4DKB0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000459">
        <property type="protein sequence ID" value="EFE37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018361.1">
        <property type="nucleotide sequence ID" value="XM_003018315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKB0"/>
    <dbReference type="GeneID" id="9584289"/>
    <dbReference type="KEGG" id="tve:TRV_07631"/>
    <dbReference type="HOGENOM" id="CLU_073350_0_0_1"/>
    <dbReference type="OrthoDB" id="4207353at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="41230" checksum="CEFA26E43942CA91" modified="2010-05-18" version="1">MAINKSFCPGNIPIAIQRFRNDDELAQFRSNTLTQPLSGGHCQVYRLGFFDDVDWAVRIPIHLSSCSEEEVVSVLMTEIETLKNLEDCQFPWSPRVIGYDMTFDNAIGFPFLVLTWIPGEPLSWTATTPRKRMDRERVVDQIAKIMLSLISCTRKDGVSALEYFTDKIDQKVIRICQGRLPELEINHCLLLKCVLPEILHPELDNAPSFIDHGDLSAGNIIVDSEYNVKGIIDWGFANYQPFQLAASLPRFLAVEHPPGLELYLMLQKDRANFLKALRRELPNSSVIVSLLLKMYSAPDVDYRRLILEAIVSKGRHKWFADRPSLYSDTPVDLKWEVSEFFARQGGQKSGLHATALMERLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE5</accession>
    <name>D4DKE5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018322.1">
        <property type="nucleotide sequence ID" value="XM_003018276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKE5"/>
    <dbReference type="GeneID" id="9580024"/>
    <dbReference type="KEGG" id="tve:TRV_07667"/>
    <dbReference type="HOGENOM" id="CLU_007901_1_0_1"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69983" checksum="B4DEC822AF44CF56" modified="2010-05-18" version="1">MSNRCLFSYQFPHRVYDSKVYPIQSPNGSTVIIYGHDFGIRILWRGGKNFKKQKAQQDDAEAKAPVNGVDNNDSIMIIDSDDEEPAPTPQPEIALPEFEDDEEEIDPSRPFENIIQYLDVKLDTKVLGIAVPSILPGAARFLSSISPILSNMIVVTAVCSDSSVRIVAVPLIPPPPGTVDAEFWKPQIISLGEGSVQGPPATAAITSTRQTPTDEDGNRRSQSRGRAMQDTPPSVGNWEILVAIHTSDLSGKLSIYRIPFNGEMAQGKLYSLSTEPQLPIRQQFLKSPASSISFSPCQYPSERHSQLLLSFTNGSVKVYSCLSTPQVSNLDRKRSGTNAETGDATGRWLVTLYTDFDQVPGEVPRRKGIVDAKWALGGKGVFVLLSNGEWGVWDIDSSQGDNAHQGRSTSSLSSFAIAGRVGPSERTVRSQGHADTSESKLVQFAPLTPSTRRIREEALFKGVPNSATQHATRGSICIIPSNQTWDQPADESVLLWHGTRNAYIPSLAGLRRNYGKQGLFGNNQAGPKPTLIEHINLLGEVQKGIRFLSLPTPANQFNLTPIPTILITAERRLIILAENILDSAEAKQKAQQQGNAPVVEEDDQTMLQRGELDITGMGRVLAGMAASSEASFGRGMQTSSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKG2</accession>
    <name>D4DKG2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018305.1">
        <property type="nucleotide sequence ID" value="XM_003018259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKG2"/>
    <dbReference type="GeneID" id="9580001"/>
    <dbReference type="KEGG" id="tve:TRV_07684"/>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="143"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48969" checksum="54575F9F7AF97C27" modified="2010-05-18" version="1">MPTVFSFFPIFRNIMIREQIEVVHGHGSLSCFCHEAILHARTMGLRTVFTDHSLFGFADASSILTNKLLKFTLSDVDHVICVSHTCKENTVLRASLDPMMVSVIPNALVAENFRPPSYTESVSGSLNNRPLTHRMPGPRLLGPDDTITIVVISRLFYNKGTDLLIAAIPRILALNKNVRFIIGGSGPKAIDLEQMLERKVLQDKVELLGPIKHEDVRDVMIKGHIYLHPSLTEAFGTVIVEAASCGLYIVCTRVGGIPEVLPQHMTTFAKPEEDDLVQATGKAIAALRSNKVRTEKFHDQVRMMYSWTDVARRTERVYDGICGAISEEEFYGNFPKESWTGSRRREHSFALIDRLKRYYGCGIWAGKLFCLCVVIDFLLYVFLELWMPRSSIDIARDWPKKPVGREGSQLLDVRQPMDNARHHPGNETWQEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN7</accession>
    <name>D4DKN7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000477">
        <property type="protein sequence ID" value="EFE37581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018226.1">
        <property type="nucleotide sequence ID" value="XM_003018180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKN7"/>
    <dbReference type="GeneID" id="9579602"/>
    <dbReference type="KEGG" id="tve:TRV_07759"/>
    <dbReference type="HOGENOM" id="CLU_731949_0_0_1"/>
    <dbReference type="OrthoDB" id="4174439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="456" mass="46536" checksum="1E264B9F6E6E6E8F" modified="2010-05-18" version="1" fragment="single">RPGKPGETLPSPLSRCLALLVLFLSLALRARGWRAGGDSRPSRRRLLHKAAVPCLSFSISLSCLFPLFSLSLSLEYPSVYLVHLPRLSCKMARLLSFLALVALCLALVSGEPLRQPLLRKHHPRDAAEDNAVFSLHNLSLKLFHKRAAVADPVPGAAGAEEAARRKVLRRQNTGDIPTATPTGTDSDSASASPTASPSPTASPTASPPASPTASPPASPTTDGSSSSPADTPTKPPTNSPTSNPPTNPPTSSPTNPPTNPPTNSPTSRPTDSPTASPTDSPTSSPTQPPTRPPTSPPTSSPTNPPTSSPTDSPTNSPTSTPNETSNQPTSQPSMTSQRPTSQDTTLVTETSPSPTRASSETSRPATTEPPSTTTRPRSSSTSTSIGVVTEADGSVHTYTSVVVVYPTPSDGGNGGSPASPTASPTLQNGAAPVASVGLTGVFAAVLGGAVGVALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKP6</accession>
    <name>D4DKP6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000478">
        <property type="protein sequence ID" value="EFE37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018223.1">
        <property type="nucleotide sequence ID" value="XM_003018177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKP6"/>
    <dbReference type="GeneID" id="9579593"/>
    <dbReference type="KEGG" id="tve:TRV_07769"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF302">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="268" mass="28253" checksum="F6FC9D6F0CEF4282" modified="2010-05-18" version="1">MALANLVITLPVAISAPPSRSMARRPTLVNIRLAKKPAFILQSLAALLQASGNFVPMTFLPEFSTVIGYSVSFGATLLAVNNGINAVSRVLMGVTADKLGRQNTLVLGVAGSAASVWCLWLAAAVNGGKAAWLTFVVVYGILAAINPPSPPSNRHNCSGMTANSSVIGAFNALFPTTITEIFGVHAYASVNGFLYFVRGLGALFGSPVAGFILGDSRVPSPGQETSTLLHDYRNLIWYDGGLLLASSLCVIGVRGFDALEKRKWAWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL20</accession>
    <name>D4DL20_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000489">
        <property type="protein sequence ID" value="EFE37458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018103.1">
        <property type="nucleotide sequence ID" value="XM_003018057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL20"/>
    <dbReference type="GeneID" id="9579312"/>
    <dbReference type="KEGG" id="tve:TRV_07894"/>
    <dbReference type="HOGENOM" id="CLU_069188_2_0_1"/>
    <dbReference type="OrthoDB" id="5207784at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="260" mass="28595" checksum="E345C61110DAFA80" modified="2010-05-18" version="1">MNNGAKTDLGGSLNKMATTPKPEGLQAQEGRNLPTDVDGNLPSYTQNPSKDDQLPPETLLLAGDAIHGTSTPVSCSTPLYKLSLDISFLRKNNTKVELSRFENRIHNRNTAGSPEVSARERHIFNLTRPPTVTTPLFEYHLEPASHGSLGHIGLKRYHHILSSGYQAWKATIPCPGADLEAKDIVFTAKTHGKGRLEWHEAGNGAPLLAYDTIDDGIFRLDIVKSMPQNQRDALVGVWCLRIWREIANSNIEPVGWDGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLD3</accession>
    <name>D4DLD3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_08007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018003.1">
        <property type="nucleotide sequence ID" value="XM_003017957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLD3"/>
    <dbReference type="GeneID" id="9579131"/>
    <dbReference type="KEGG" id="tve:TRV_08007"/>
    <dbReference type="HOGENOM" id="CLU_041802_3_0_1"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="330" mass="36574" checksum="FE7A49A26789FB09" modified="2010-05-18" version="1">MVFGEITTKARLDYQKIIRDAIKDIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYDEALEKLGAGDQGIMFGYATDETPELFPLTIQLAHKLNRAMKDARKDGSLPWLRPDTKTQVTIEYAHDNGAVKPVRVDTVVVSAQHSEEITTEVLRKEILEKIIKKVIPANLLDDRTIYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYVARWIAKSIVHSKLARRALVQLSYAIGVAEPLSIFVETYGTSSKTSDELVDIIRKNFDLRPGVIVKDLDLAKPIYFQTAKNGHFTDQSFSWEKPKTLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLK7</accession>
    <name>D4DLK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_08081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017915.1">
        <property type="nucleotide sequence ID" value="XM_003017869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLK7"/>
    <dbReference type="GeneID" id="9579793"/>
    <dbReference type="KEGG" id="tve:TRV_08081"/>
    <dbReference type="HOGENOM" id="CLU_012821_0_0_1"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="196"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="564" mass="62328" checksum="78573D4A5E6FBFD7" modified="2010-05-18" version="1">MTHGGQQKLTAEERRKREQSLSEFAEYVEKQQEKRYLRSQNRDGSVAPSDSGYSTTAISTAHDDHSELDILDQLGLSDHPSSVQLKDLLLDNSPDAESNISRITSVVKGRLEEGQGETIFDLGQEDNGDWMGFNKEQWNYALDRLRQAARELRADCRVLLTYNVGGPEEAETKSDRIKCAYGKVLIRQAPETVEKVIETRIAVVGNVDAGKSTLLGVLVKGKLDDGRGKARVNLFRHKHEIETGRTSSVGMEIMGFDTHGEIVGHGQARKQTWEEIGRQSAKVISFSDLAGHERYLRTTVFGMLSSSPNYCLLMVAANNGLIGMSKEHLGIALSLNVPVMVVITKIDICPPHILQQTVKQLTGILKSPGAHKIPIFIKSREDTVNTATQFVNHRICPIFQVSNVTGECIDLVQTFLNMLPHHGRYDSGAPLEFLVNDTFSVPFVGTVVSGVVKAGAVHTGDAVLVGPDSLGQFKNTVIKSIERKRIHVHACSAGQSASFALKGVRRKDVRKGMVVLPKLDRPPKVYREFVAEGMTTHVVAGSITFTDLDFCFSIDTFTRHYYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLP8</accession>
    <name>D4DLP8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_08122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017866.1">
        <property type="nucleotide sequence ID" value="XM_003017820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLP8"/>
    <dbReference type="GeneID" id="9583761"/>
    <dbReference type="KEGG" id="tve:TRV_08122"/>
    <dbReference type="HOGENOM" id="CLU_014420_3_1_1"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="162"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="507" mass="55971" checksum="7B804229D85E4C2C" modified="2010-05-18" version="1">MTTGGEKAREKAKRTKREYKKRHDAKRQDTGDGGYERKTTVSSSSSAIPSLELPMLMPIPVADPRPADVLHPKPRQMNLSCTKKSEIIGQEYKFYDIADKYTYAIEDPGFPHIRYRQTDVPPYHSRFSFEDSPACITFTEDARGVSTSDPWHSARANVCAREGTYYYEAKVVSGVIRGSQPGPSPRGNIRLGFARREADLDVNVGVDCYGYGIRDVNGEVVNRMRCEYFFPKDESICEGDVIGMLITLPPLELHKKVVEGTYESPAEGDEMDVDHPTPQPVPINFIRDRIPFHLKSDFMYQQSHVFASKHLRDYAFNLKETPTYGPPSPGNAEDASLRTLPGSSITIFKNGVKMGTPFQNLYAFLPPASRFAQASNNLGIGERENADDGMIGYYPTVSCHNGGAVDCRFEAPWFIGPPTDEFPNVKPFGDRFNDQICEDILADIVDEVDAICTGWKLELPVAHTAGGTNASTPAPSNLREASVASAPTSVTIDGAPDTPSAMSQAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLT3</accession>
    <name>D4DLT3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000521">
        <property type="protein sequence ID" value="EFE37189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017834.1">
        <property type="nucleotide sequence ID" value="XM_003017788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLT3"/>
    <dbReference type="GeneID" id="9583730"/>
    <dbReference type="KEGG" id="tve:TRV_08157"/>
    <dbReference type="HOGENOM" id="CLU_039745_0_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="3">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="3">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37960" checksum="0C7820120444C72F" modified="2010-05-18" version="1">MPRPDLEALGVKYRRIPVLSIGKDVYCDTRLIIKKLEEQFPDGRLGATDGEGQALENLLETWSTDGGLFLNAVLLMPLDLPSLRDPAFLKDRSTFLTGPKWKMEDMPSLRGEAMVQVKRAFDFLESTLLADGRDWLRKTEKPTLADIHGMSLICSLFLLACPGHVVGCLEMVSMDSIGRLTFSLALFFFFFPYLAIWALDWVLDMGSLEDSIISEASHPKVFAWITRFRQALSHAKGKMEEMLVSGSEVLDGLQHESFAQIDAEFDDSDPLGLEKGEEVLVWPTDSGSTHQDAGALIGLNSKEIVLQRKTADSRFDIRIHFPRLNFKVVSAAHVQQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZI6</accession>
    <name>D4CZI6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025588.1">
        <property type="nucleotide sequence ID" value="XM_003025542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZI6"/>
    <dbReference type="GeneID" id="9581826"/>
    <dbReference type="KEGG" id="tve:TRV_00228"/>
    <dbReference type="HOGENOM" id="CLU_2074847_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055197" description="Cell wall protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="11821" checksum="860128F87563E651" modified="2010-05-18" version="1">MQFSAVILLGLASAVSARPFNWFNMFNFSSSTDLPLPTATGVPTGTGTTFTVIPTGTGTGVPTPTGTGTGVPMPTGTGTGIPIPTGTGTLPYPTGTVTDTVAPSGTYHFPTAIPTPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZS7</accession>
    <name>D4CZS7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025557.1">
        <property type="nucleotide sequence ID" value="XM_003025511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZS7"/>
    <dbReference type="GeneID" id="9581795"/>
    <dbReference type="KEGG" id="tve:TRV_00320"/>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="170"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="434" mass="49008" checksum="43B2A2BF6A698C25" modified="2010-05-18" version="1">MLSGILIFNQKGENLIFRSFRNDCRPRLADIFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAVTKSNANAALVFEFLYKLIMLGKGYFGKFDEEAVKNNFVLIYELLDEILDFGYPQNTETDTLKMYITTEGVKSSIVNSATDSSRITMQATGALSWRRSDIKYRKNEAFVDVIEDVNLLMSATGTVLRADVNGHIVMRTYLSGTPECKFGLNDRLLLDNDDANGLPGKPRTTRAAAGSVTLEDCQFHQCVKLGQFDADRIISFIPPDGEFELMRYRATENVNLPFKVHPIVREVGTTKVEYSIAIKANYGPKLFATNVVVRIPTPLNTAKITERTTQGRAKYEPEHNNIVWKIARFSGQSEFVLTAEATLTSMTQQKTWSRPPLSLAFSLLMFTSSGLLVRYLKVFEKGNYSSVKWVRYMTRAGSYEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZT8</accession>
    <name>D4CZT8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_00331</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025462.1">
        <property type="nucleotide sequence ID" value="XM_003025416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZT8"/>
    <dbReference type="GeneID" id="9581733"/>
    <dbReference type="KEGG" id="tve:TRV_00331"/>
    <dbReference type="HOGENOM" id="CLU_000288_127_1_1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="493"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="778" mass="86397" checksum="9E06A7772B935477" modified="2010-05-18" version="1">MQQKKQRRTRKKQRADAMRQPVEVHERRAWPCSVVQRRASSTSQRARRQGKPDSRQGLDLMPTASLPPALALALCSLLLALALTLLLCAMIQPHQALAWLFLTQNLLLLLVSSAARRFLSRLFPTHSPATRTADTPPARRRDCQRHRQRQRDAQHQCSLPFCRLVDRRALPGLLCSLTYFLTSSARLLPYYGLLITSTTFTTNQPATSSTAATITTDTNTFPAPALLMNSFTPLSSPSPSSVSSSTSHSQHEDPQLTRALEDSRQPAPPTTSAPAPAPGPPNTASSTATTASLLSAASSIVPQKPPKAKMTNRLSRMFSQTRSSAPSASVSPNRQSLDPSPRQNGDSTIASTMMMPPPSSSPATGPTDRKADQKVGEKKPDGKPADKRAEKGKDAVQPIKRFELLPDGTHKHTLKSARRQEKLSDMLRDMIGAGKKKEDAAAAHAHPPGQADDQQQLSLVSTWVDQLKNEKEKMAADKKGGPNSTASLVDKYGKCHEIVGRGAFGIVRISHKIDPKDSKTEHVYAVKEFRRRPQETVKKYQKRLTSEFCISSSLRHPNIIHTLDLMQDAKGDYCEVMEYCAGGDLYTLILAAGKLEVGEADCYFKQLMRGVEYMHEMGVAHRDLKPENLLLTTHGALKITDFGNGECFRMAWEKEAHMTAGLCGSAPYIAPEEYVDKEFDPRAVDLWATGVIYMAMRTGRHLWRQAQKEEDEFYDRYLEGRRDEDGYAPIETLHRARCRNVIYSILDPNPGRRITASQVLKSEWVRDIKLCKAGEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D030</accession>
    <name>D4D030_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_00424</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025363.1">
        <property type="nucleotide sequence ID" value="XM_003025317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D030"/>
    <dbReference type="GeneID" id="9581599"/>
    <dbReference type="KEGG" id="tve:TRV_00424"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="54"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="530"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="567" mass="63465" checksum="6673CB1B99E5B5E7" modified="2010-05-18" version="1">MSSTNANTVDTSVESGSIPPGIIQAVNEMKPKPSRKKLHGREFYESIGSPKMVVAPMVDRSEFAWRMLTRSFMGEGNPTPILAYSPMFHARFFNEAPAYRTQHFEPVRQAKTVGTDETTAEPYLDGNPKHDRPLIVQFCANDPDELLKAARHVEAHCDAVDLNLGCPQGIAKKGHYGAFLQEDPDLIYKLINKLHNELSIPVTAKFRILETKEKTLEYARMILSAGASILSVHGRRREQKGHNTGVANWEYIRYLRDNLPPETVIFANGNILNHSDISRCLEVTGADGVMSAEGNLSDPTIFSTPPAPGEEGRMYWRGRDGRGGFRLDYVLRRYMDIIYKYVLEQDPPQRAPLYHPDDEPASESNGQIQTDEAVEDESEQPPRKKQKQGKRAKRTPSTNLSSMQGHLFQLLRHLVSHRTDIRDALARCHGGDMPNFEKVVKLVDHAVKQGMQEYEQNPDWKHVVPASKPGVVKSEESKATMEKYQRPWWVCQPYIRPLPEEALQIGSLQLKKKDKLAEEAQLIDIKAGAVKGEHGNGNGVPVSSLEPVNGKGDENNVTITPDPLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D092</accession>
    <name>D4D092_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000024">
        <property type="protein sequence ID" value="EFE44737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025348.1">
        <property type="nucleotide sequence ID" value="XM_003025302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D092"/>
    <dbReference type="GeneID" id="9582959"/>
    <dbReference type="KEGG" id="tve:TRV_00487"/>
    <dbReference type="HOGENOM" id="CLU_018186_0_0_1"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="183"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="674" mass="75177" checksum="6980D658A05940D2" modified="2010-05-18" version="1">MADCFFLGQSRNQLNASSAESSKIVQQELLQRIRNLEDLLKKHVGAHAIVGGQAGQDEPVSPPTTNASASTEADCGSNKSFSNSNNHNSNSNSNNNSSELPQSLLQNVGSLSISPQGHVRFEPQSSKLDFHLAQISASEYRNQVNSVNEEKPSGFPFGCDDPASRDRLLARLPPSRYCDALKDTYFRVFSPLFHILHDPTFAEEYERFRQDPGSVSLSWLALLFVVLAIGVTSLSDDDPLLPDLGREATPSANIRVISEQYRSAAMQCLAADQVLSRHSMKTLQALVLLIYALTHSSQPSWVLIGMTHHVAIAMGCHLDPDNFNLSLVEAEERRRCWAGLIMLHMIQKISFRNLDRQRLSRDVRLPLDANDLDLMKNSGLTMDQLRHPTGPTQMTYLLFKFRLYDIALAICNEIFSSEASPAVIAKLDNDITSQQELWTARYHSDTSVEPLPSQHFAHINILFGYSHQLRLLLHRPALNRYLTGDINDRTHSSRNRCLDAAKGLLSIQKTLAESPQYAPYKWYTAGLASFHAFHAAVVLTVIMMNPESQAEYDEIHALLVDALQVFHLLSSRSSLCEKGIPILSQLLEMASPQPQHLSIPQQQQPSQPELMSNTVPSPQDTPISLLTHGGSVSEPTFDFANTHTETIQSQLQAQYWVTASSIPWNNWGFLIHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0C3</accession>
    <name>D4D0C3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025338.1">
        <property type="nucleotide sequence ID" value="XM_003025292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0C3"/>
    <dbReference type="GeneID" id="9582949"/>
    <dbReference type="KEGG" id="tve:TRV_00518"/>
    <dbReference type="HOGENOM" id="CLU_009555_1_0_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="557" mass="61649" checksum="4A91162CD1215AE9" modified="2010-05-18" version="1">MLPSASFIRFWSTDLTRDAFLSQVSKEDLANLRLVCHDFSVHVEPILFSELNVSFRSSTFTRPARMDALERIGRHVKSLKLTISHSPSTFLPPLLDPNTGEEQTFVYTPQVYPSSPFSSRLSGPKYGTWEMTDLLTKQYPPLFHAATNIGSFIRAFKALDGLTKLTLSCPNQSAPHRYRRSVVDYALISIRCAVEHSPLPCLASLTLLPMHPGALLYLRPTAVGIGTSPASCKRWRRITDLHIEMDAFPYSGGEPTDHLKFLDSYLQCFPLLKRLKFRWLGARGPSPLSLSTEPCLTTNKQNQFSSAQPKRVKALIFPSLHRLEIENVHVDASQVSSFIRNHRNALREINFEATTLRSGTWDDALAPLAPSPKKAKPSPSPPPPGQKSVATKEVEVMDVPLVLSAAGMEIKQLQRLVLEEAGRRKKGRRNKTGSSIRLWGRGKAISTVGSGSTVSAGSGTGAGSKIGYGQVQLQKATDRTRELLGPFFCLLFFSFFLPLCRASFFVLFYFYVYNGHSLRPFFMFLLRYLVASGVVGVAASESVWGTSAVFLGGGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D161</accession>
    <name>D4D161_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025004.1">
        <property type="nucleotide sequence ID" value="XM_003024958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D161"/>
    <dbReference type="GeneID" id="9580496"/>
    <dbReference type="KEGG" id="tve:TRV_00809"/>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="270" mass="31295" checksum="3AC7CCB30E5826A9" modified="2010-05-18" version="1">MSQYNQPRPQDPNAILNQCRDVDRGIDDVNRYVDQLSTLYRRLLSDVDPARENAVREEVEDLANQTKRLYRNLVDRVKSIKQMPESGSPRNSSQVGKVERSLKAAITRYQQVQADFRKESESQMARQYRIVRPDATDAEVREAVQDSSNQQIFSQALIQSDRRGDAQKVSQMVRARHEEIQKIERDFVELTQMFHDLEAMVIQQEEPIAHIDQTGEEVRENVDKANEEIKGAIDSARARNRKKWWCLLICLLIIIIIVVVIVVVVVIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1E7</accession>
    <name>D4D1E7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024976.1">
        <property type="nucleotide sequence ID" value="XM_003024930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1E7"/>
    <dbReference type="GeneID" id="9580468"/>
    <dbReference type="KEGG" id="tve:TRV_00897"/>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="612"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="877" mass="97098" checksum="B720B7CECFBCB3C5" modified="2010-05-18" version="1">MPTNGEPETDPLDGADYNPIEHLNAIFSHPSTLAAVPKTSQVLKVYQDELDENISALVEAQAASNLESVERIHNAKEDMAELFKKIEEVRERALKTEQAITAMTADIKQLDNAKGNLTLSMTTLKRLQMLTTAYEQLKALSKSRQYRDCAQLLQAVIQLMAHFKSYRSIDQIATLSRNVADIQRELLEQVCEDFEIIFAKGETAQKRNILAEGCLVMEALGEMAKSRLITWYCNTQLREYRQVFRGNEEAGSLDNISRRYSWFKRMLKTYDEEHMTIFPASWKVNEVLANIFCEGTRDDFKGLLSRSVRSGQTMDVNLILSCLQESLDFEQYLDRRFTNASRASTDTFASSETPIFSQTISEAFEPYLSLWVSAQDKQLDTLIRKYREQPIKPEDEEYSPQLVVHSSTELFTFYRLSLAQCAKLSTGNSLAELTKVFARYLDQYAQQVLLHYISDRPGNQASSKLPSCEDLTMVLNTADYCYTTCNQLEDKIRSKIDEPFKQQVDLQSQADSFMGIASAIVRLLVRKVDIGMEPAWREMRNTSWSAQDGVGDQSPYVEVLLSNLKSKSDETLGMLHKQQYQRAFADNLVEHTSTSYISNIYQCKPVSEAGAEQMLLDSYGIKTGLTGLLSPAPTAFVKRVHQSSQKIDTLLKTLQVRAVPPEALVQAYLIHIADRNDNNFRKILDIKGIRSKQEQNRLVELFQAHKTSNRHASNLQESNPLISYLQPPAPPAPTAPTVAQGLGLGNLGGTPTSSSGANTLPTRFDPSMLGSALISAARDGVDRLGTPGLGNLGNTPGGISASSGRAVAGSVAQSGSGTPLSNQNINSTGQNADASEGASSAAANLNENLKNIGKFFRRDLSGLGGRFGIGGDDSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1H0</accession>
    <name>D4D1H0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024915.1">
        <property type="nucleotide sequence ID" value="XM_003024869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1H0"/>
    <dbReference type="GeneID" id="9580406"/>
    <dbReference type="KEGG" id="tve:TRV_00920"/>
    <dbReference type="HOGENOM" id="CLU_3088986_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="52" mass="5636" checksum="1E4A4A670B7AACED" modified="2010-05-18" version="1">MLLGYKKYSAHMGINSWQSLSPFPGPEFSSSSHGTSKHKAENDIPSLQKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K8</accession>
    <name>D4D1K8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024884.1">
        <property type="nucleotide sequence ID" value="XM_003024838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K8"/>
    <dbReference type="GeneID" id="9580375"/>
    <dbReference type="KEGG" id="tve:TRV_00959"/>
    <dbReference type="HOGENOM" id="CLU_074603_1_0_1"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="29075" checksum="ACB1C9E9161991D3" modified="2010-05-18" version="1">MRKHKANRHRKLEEKEEKSPAKETPRDARQPTRRLEVLRKESERESYEAITMAANETKISGITTNALTGERHIPASVRADGSQRREIRIRPGYSPPEDVELYRNRAAASWKNRGKTGVPGAELAVSENTASSAKNTKKKDTKPKTKASSEGISPKTGKETTALDKDSWRSTAGKDAASEVRQKEEPEADPAIEREKKARNLKKKLKQARELRDKKDKGESLLPEQLEKIIRINELVRQLESLGFETDGEKKADSTEPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2D2</accession>
    <name>MEP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable extracellular metalloproteinase 2</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fungalysin MEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEP2</name>
        <name type="ORF">TRV_01237</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase probably acting as a virulence factor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="ACYE01000067">
        <property type="protein sequence ID" value="EFE43987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024598.1">
        <property type="nucleotide sequence ID" value="XM_003024552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2D2"/>
    <dbReference type="SMR" id="D4D2D2"/>
    <dbReference type="MEROPS" id="M36.001"/>
    <dbReference type="GlyCosmos" id="D4D2D2">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9579926"/>
    <dbReference type="KEGG" id="tve:TRV_01237"/>
    <dbReference type="HOGENOM" id="CLU_012703_3_0_1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397728" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397729" description="Probable extracellular metalloproteinase 2">
        <location>
            <begin position="245"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="632" mass="69836" checksum="06B76A188521A3EA" modified="2010-05-18" version="1" precursor="true">MHGLLLAGLAAALPLGVAGLPARQQSGLSPRGIDINPYRFASMAKYSEHKATSQMVHSFSYSKDDDYVATATKLVKSTFPNMTFRTVKDHYIGTNGIGHVHFKQTAHGIDIDNADFNVNIGRDGKVFTFGNSFYEGEMPKTNPLTKRDFSDPVKALHGAIKTLKLPVKPQSAKAMPMKEAETFKFEGTSGALSDPMAKLVYIQKDGKLHLTWRVETDVGDNWLLSYVDSKETETVHNVVDYVASADYKVFAWGLNDPTEGQPTMIKDPWNTTGTGSPFTWHGDGQMDYTVTRGNNIAAQDNPSGGEQWENNYRPDSPELSFVYEYNEQMEPEQYKDFAITQLFYTTNTFHDVLYSLGFTEEAGNFQMNNNGKGGEGNDFAICNAQDGSGTNNANFATPPDGQNGRMRMYTWTTAQPSRDGDLEAGIVIHEYTHGLSNRLCGGPANSNCLTELEAGGMGEGWGDFYATAIRLKQDDTHDTDYTMGEWAANMQGGIREYPYSTNMQTNPYTYADVQGMDEVHGIGTVWATILYEVLWNLIDEHGMSKNIMPKFVNGAPSDGRNLAMKLVLDGMTLMPCNPNFMQARDAIIDADQALTNGQNKCALMKAFSKRGLGANYKHGKTRVNNFDMPADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H5</accession>
    <name>D4D2H5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024568.1">
        <property type="nucleotide sequence ID" value="XM_003024522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H5"/>
    <dbReference type="GeneID" id="9579892"/>
    <dbReference type="KEGG" id="tve:TRV_01280"/>
    <dbReference type="HOGENOM" id="CLU_008570_0_0_1"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="785"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="785"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="864"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="925"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1232" mass="132731" checksum="43533ACA247A84DD" modified="2010-05-18" version="1">MSSSQAVAASLMGPPPPDAVPERSSFDRLDDRHQQHPQHHREQSQRQTTPTPASTAAEEASAATLPSAANTSETKLSSEDGPDRQRSPQSESQKQAAASTLLAQLLSSQTTAAAAAPNTDTSVTATTTTTTTDNNSNNTSPDHPVAAANSDGNAWSNSSEQKQPEQDKKPEIAATQPNATDASAVNDFHGLPKMGDLSASDALPAIDMQADPSMLGSLDNVDLKVSDLNAHNFSDFSALATTPVNPRDAIDQNALLTSGAAYYDDSPTMNGGGPTPRIVGYPDFSNSTDVKGREGSESVAGSEPRIQAFAKLEFDDGHFYVNTYSFILGRDVRAARAAFQREYQAKQNNKAHSSSGHKTRTPSRVKREGSAYMGSVISDKGGIMGFDPDIPQNGPPQMSWKSSNSSADQVARPLLHISQGESQENSEPREMTDYNALAMQSLQRGHHEPKRVDTLSLLPSPEACPTIPIHPPMPAHGGSSHRAISRKHVKIAYNFHKNVFEMEVIGRNGAFMGADWLAPGQVRPLHSGDFIQIGGVRVRFLLPDVPIGDTGADAAPSSPPEMGQGLPDQPDNEEPEASVERPTVEKESERSEADEPVKAKGKTQQQQRPDPKATVAEPGQAKRRGPGRPPKDGIMSKRERAEIAREQKLAAKREANGAAAATAISPPPAGTTAGKKPAKAAKEPASASATAPPAAASAISPEDPSTAPVKVEKRKYTKRKKPDSTPGETVMQSIEGGGAGIAANMEIQQHTEPIRPPAPKKRKPSKSPSPDYPPESFYTPKELAKPPYNYAVLIFDALSESPTPMTLKQIYRALKLKYPYFRFKCETEGWTSSVRHNLNGNTHLFMHAERDGKGWSWKLIPGASVDKEKKRRPSPPPVQDVSSNSQQRFLPPNTPGAPYNAPPGQFNNNRRQYPPYQQPPPNAQFPPHQQQQQQQQAPLQAPSATQPSQPVAAAKPPPLPPPPQPPAAVAVPPAHPPTPNLPPQLLKSLPPALSVVNLTPYRSPYILASPFPPPQQRPPHQQPIQPHPPPPTHPPIHHQQQQPRSLPPQMQQPHHSQPPPQQQQPPPNQYRFHNQILPPNHGQPHRPPQQPQPPPPPQHAQAPPPPPLHNTPVTSAPASQPSHPPPTTAPASTQPNASVPAPVPTPAQTPVQKPGGMDPAFLARANQAIDNFEAVLIEDYEDKDYIRNVLRSARDRVLHNAKESSFPGGETKDETVIIDALRGIIGSLGQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X5</accession>
    <name>D4D2X5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024365.1">
        <property type="nucleotide sequence ID" value="XM_003024319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2X5"/>
    <dbReference type="GeneID" id="9579631"/>
    <dbReference type="KEGG" id="tve:TRV_01431"/>
    <dbReference type="HOGENOM" id="CLU_014853_0_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="206"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="423" mass="45439" checksum="F5B05682A4093915" modified="2010-05-18" version="1" fragment="single">MASSTVSQVNGHGSGLLSSPELANGHSTSTPGGTLDHSNGDGDSDIYNASSVAAIKATLSQLQDREALVTARLDALVASQKDLSRELGRLDLLRAHLGTQASTTRSISHEMLSGAASSAHSLSSAVRKLDLEQSRVRSILDMVGQVAELKACVLGVAGSMGASQNWEMAASYMHRASKIPEEVVNSPFAAEIVPTTEVPDTPNVTLSNAAESLCALFLREFEQAVKENDGAKITRFFKLFPLIGKSDVGLDVYGRYVCQGVAARARSNLNAGTGGAQAKDDFFYANALTRLFEHIAQIVDAHGALVERHYGPGKMGRVVERLQVEADVQGGIILESWAEERHVDRKLTDIKSYAFTFLVQSFLPAARGAGTPRSNSPASWDTPQRNSEDEGVDMKEIDSILNEISIMLGRWSLYGRFLASKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Z7</accession>
    <name>D4D2Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNF2 family helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024387.1">
        <property type="nucleotide sequence ID" value="XM_003024341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579527"/>
    <dbReference type="KEGG" id="tve:TRV_01454"/>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="OrthoDB" id="4169731at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1856"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1360"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2047" mass="231178" checksum="E3DED4ED868A9276" modified="2010-05-18" version="1">MKLSRKRGKYTILPGERPKPGLDRSLPPICKIEDIFEDLTAQALKNGFDSFLKHIGSRELRVATMCSGTESPLLALEMIQSSLRQITGKTFRLHHLFSAEIDAFKQSYIQRNFSPEIIFRDVNELVAEEATTAFGSVKKVPTDPDLLVVGFSCVDFSALNFYRKTLEEMGESGHTFYGVIRYMQRCRPALVVLENVCSAPWEQIKTILQEINYNGYHMKIDSKNYYLPQTRERGYMICIDQRRLVTEPVGEAKSKKLSAFAQLMKKLERPASSPVTQFLLSQDDIRLQDAVNDISANSNKDRQAVDWTRYKARHLGYRMREGLGDKRPLTKWQENGTCQMPDFYWHGWSRTQTERVWDTLDVNFLRTIARGYDINSKSRVIDLSQGLDRELDQRASGVAGCLTPRGQHFITSRGGPLLRIEALALQGIPIDRLLIGNDGQRDLHDLAGNAMTSTVVGAAIITALTLGYQALPLPTTPCDHDDSELIFQQRSIAPNHTMVPLLANIADDNGILTGELYQLSLRTARLCYCDGHTGTRSDIILTCVACGHTACSKCGKNPPHCYIPVETDELKLRLPPIEFETQVKTRLPMCLQISGLSVDMFQDLRESDMPPDVNDAWDTFINSIKHSLSDVLKFQGVMRQSGWTITYEGTNSFLKLTCTSIGLQWLLYVIPSKSEPSNSPLRQMLSRPIAKMTPRGSSLFDGTWLIGSPISSQFDLLVAGGGDLVDSLPARSGLQHPSFRNLKTWSILHIDAKTEEMRNLEIDIRGAYELLPDCGAASGSLRKRLNSPGSPVYLFLDPTEIGPHQLDSWVFSLEHERLGFGQARNTIAEVRPNWSPLYLSHGQDIVPCWYRKWRESASVALSVYRISPPPQFSIPGPSEVLASCSCTCDGSYSTIIQCSVPAGLSDLEIVPGMVKKENLLESASMLKKFGWVLQRAIGITQFEDWETVQISFPDFKLDCSTCAPEKPRLAWALDEKDRVYAYENPEDAASFERSIKSRPAPFLGFTTLDESSILHLQICLNVLSLLHRAAGNLGVKDNVTLQWRLCIDTTGFIPRRLLKLLEKNNKLDAPHTQPPNFRRHYLRPEQLRSLQWMCNQESDHAPVFVEEEVVEALLPIINWRAEGKASTEKMVLGGILGDEVGYGKTAISLGLIDVQYEKDGATVPASVNGRIPIKATMILVPSHLFDQWKREIHKFLGNTYRILEVKTNFSHGSTTIRDFEEADIVLVSTSVLKGTAYYTMMECFAAAPELPKGEGRIFVEWLHDALGSLSEQVDRLLTSGALSVLKYIEDRKEGLRQGNGLSKYKPSRRLKGQKFQEHLQKMRQAAGITDHETTVKDTADGNVDSIDSAVELGKRKREASPVGQVMEIQQEPKKPKKAAQTRKDGGNISVEIFHLCQSSTDWRKVRSPLLHMFEFNRVIIDEFTYSKDRNYAAALAISSRKKWILSGTPPLNNFADVKSFSPFLGINLGIDEDDGRKVENERLRTIQRERTEVEQFQPLVTRRSTVWHERRHQIAQGFLDQFMRKNIPDIDDIPWTEHIIGVSLSAAERAVYLELFMQLMSQNLRLRKHGRGLYDSEEIARLDEIIGNSSSPEEALCKRCSLFVYNDPLSSSDSASPEETNEMKLVDDNPLIHTRRKQISSLAADIMSRVRRGLWLRGQLDEGTTHFDRLLESIEQDRFGDLLVTAGIKMLLKRAKAISDSNDGSMFYLATLEKKKNPDDPRPEFPKNQTELISDLNYCTDSLRRLVYETIAHTRALRLYHAVQCFQDPPPSSKFICYSCSSEREDPRSLSILGECGHSACESCIERCQLHERCLLEGCSGTVHEYRIIKWTDLCHPEWHTQTDKLAKYGSSKFTAVIELLEDTEKVPADDQVLLFIQFPELMDAASKALEAASIPHTVIQPGDRTPTSKISEFQNGKESVKSKVLILNLGDVTASGLNLQNANHIIFFGPLVARSQYDYDSGMAQAIGRSRRYGQLKHVHIYHVLALRRVEVNIFEQRRKQYLAKRGDRFITVQKSEIEETDKIDWKGFPLEGSNAESYQDDFDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D343</accession>
    <name>D4D343_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024363.1">
        <property type="nucleotide sequence ID" value="XM_003024317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D343"/>
    <dbReference type="GeneID" id="9579502"/>
    <dbReference type="KEGG" id="tve:TRV_01500"/>
    <dbReference type="HOGENOM" id="CLU_2544244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="83" mass="8843" checksum="19C08D7FA84F1212" modified="2010-05-18" version="1">MGEKSPASGPVSLSHPAHCLTAEAATRELATNADDGLTAQEAKARLEKYGQNKLDDGEGVSVIKILIRQIANAMMLVKRPIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3A3</accession>
    <name>D4D3A3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024283.1">
        <property type="nucleotide sequence ID" value="XM_003024237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3A3"/>
    <dbReference type="GeneID" id="9579403"/>
    <dbReference type="KEGG" id="tve:TRV_01562"/>
    <dbReference type="HOGENOM" id="CLU_2361257_0_0_1"/>
    <dbReference type="OrthoDB" id="2935237at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="96" mass="11215" checksum="DFE2DB2316658635" modified="2010-05-18" version="1">MPHPHLGAVKDGRLLEEAFEPKKYMVRLEKGKFIPALDKDPDGRVKWRAMSPYNYRLVFDKSPYPAGEHWKDPEICDDAKSAHEWKEFHAGSTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3B0</accession>
    <name>D4D3B0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024219.1">
        <property type="nucleotide sequence ID" value="XM_003024173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3B0"/>
    <dbReference type="GeneID" id="9579394"/>
    <dbReference type="KEGG" id="tve:TRV_01569"/>
    <dbReference type="HOGENOM" id="CLU_102995_0_0_1"/>
    <dbReference type="OrthoDB" id="4172922at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="156" mass="17791" checksum="D675ACEE31F32A4B" modified="2010-05-18" version="1">MKPGTPHKDKAIFYTARTLFSALHLIQRFNGQGISDTDNGEKVMDMEGGPFAESTKLFLNDKDTWDDDEKDIAVGQVSRAFAERAKGIVRVVFPEDYSPHIRPNTWTEYEWPALKENPDVTKVLAWWVKKGGDEPMGDGTEIWPCDMTTDPRRQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Y1</accession>
    <name>D4D3Y1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024027.1">
        <property type="nucleotide sequence ID" value="XM_003023981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Y1"/>
    <dbReference type="GeneID" id="9582720"/>
    <dbReference type="KEGG" id="tve:TRV_01794"/>
    <dbReference type="HOGENOM" id="CLU_426538_0_0_1"/>
    <dbReference type="OrthoDB" id="4492028at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="646" mass="70671" checksum="B670249D4E6E14BF" modified="2010-05-18" version="1">MSRCHYYVVDDDEDDDVQIVGVNSLNPEAAPGPQLGEYRLDAPRSFYQGTSYLSQPFYTGLAAHEMLATSAAGLGGVAPLIPFPAASYQSFSGQLSAAESVSAGQFFPPAAQTGHIVDLGSVAASEAAPISESPAASASASGSSSSLSSSSTSSYGQATRSDYELDPTSSQTQTAPAPVLATIHEQSPTGDTVGRSAWSGIAYGNILKILIGPRNCDTTTNPDQFPPSFFSDLASTIVSSFPYEDFAYKHRCTVDEVNHALVAQVVAPLIQCHSVDKKQMADTANDIYNRWVPSDYQYHDQHASPSSQAIVTTPNLSEPHETSASEKCPSPQLTREETLEYARVLLEGIADYAFGTNNDTQAQNNAVPQAQTVGTPKPVPTSNIQAPSEVEPVNKNEHIFTTPSPPRSQTKDTNSSRRPMKHAKSPSCLTRVSSSTSSSTHSAPIKPKRRYEDIADPESPSPQNQLSRNEREDTPRPTKKAKPDFNCPPPSPKACEKQSHPSLPKLQNSEKAKKMDVCPAKPHTYVPLTDETRIKRQRVTVDPFGKFKKVSPYLEPNRNYTNILLERGVPLENHPRTKRPLTERDIETIKKGQKNFFKYAMKLQCEHMDRLGLPHPIPKEHLIDEGEDEASAPEDFYHWDDEGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>D4D415</accession>
    <name>D4D415_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ABC metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01828</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024061.1">
        <property type="nucleotide sequence ID" value="XM_003024015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582754"/>
    <dbReference type="KEGG" id="tve:TRV_01828"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="303"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="623"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="974"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1292"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1527" mass="171084" checksum="F9443889212C8EBE" modified="2010-05-18" version="1">MAGIDGEQAVLALSSSEIADVVAGPLAHARHFCGDAEGWGPISSIRYGLTPCFLDVFICFVAVFGLVGSAGALWLLLRHRTAENIPRNWHFYAKLSLIWALVIVVGLQASLQIENLPHVWASDFRFWTTILLLLSFVCIYAVQYHEHWRSRQPNGVVLFYWLFFLIAHGVKLQSLASRQYYRDHLPYFITFNVGLGIALLEFILEYFVKKKQSVYHALGDEDECPFEYADIFSVLTFSWMTPLMKQGYKSFLTQDDMWNLRERDTTRVTGEKLQSVWEDELRKKKPSLWMALFRAFSAPYFRGALIKCLSDILAFVQPQLLRMLISFVDSYKTNNPQPAIRGVAIALAMFIVSVVQTTCLHQYFQRAFETGMRVKSSLTAMIYTKALKLSNEGRATKSTGDIVNRMAVDQQRLSDLAQFGTQLWSAPFQITLCMISLYDLIGWSMWAGIAAMVLMIPLNGFIANVMKTLQVKQMKNKDQRTRLMTEILNNMKSIKLYAWNTAFMSKLNHVRNDLELNTLRKIGATQAIANFTWSSTPFLVSCSTFAVFVWITDKPLTTDIVFPALTLFNLLTFPLAILPMVITSIIESSVAITRLTAYLTSEELQENAVQYQDAVTHTGDEAVSIRDATFTWNKYESGNELENLNFSARKGELSCIVGRVGAGKSSLLQTLLGDLYKVSGEVVVKGRIAYVAQQAWIMNASVRDNIVFGHRWDPHFYELTVAACALLDDFKTLPDGDQTEVGERGISLSGGQKARLSLARAVYARADVYLLDDCLSAVDQHVGRHLINRVLGKNGILSTKTRILATNAITVLKEADFIALLRNRTIIEKGTYEQLLAMKGEVANLIRTAITEDDSRSSGSSKDDGLGGSESSSTMIDIEDDSPIASDTEEAQERFAPLAPIRSAGGVKPRRESTTTLRRASTVSRPNFRGKITDEEEVLKSKQTKEGMEQGKVKWSVYGEYARTSNLYAVSAYLIILVMAHGTQVAGNFWLKQWSELNEKEGINAEIGKYLGIYFAFGIGSSALVILQTLILWILCSIEASRKLHERMAFAIFRSPMSFFETTPAGRILNRFSSDMYRVDEMLARTFNMLFSNSARAIFTVVVIGISTPWFLVLVLPLGYVYLRYQKYYLRTSRELKRLDSVSKSPIFAHFQESLGGISTIRAFRQQKRFAQDNEWRMDANIRAYFPSISANRWLAVRLEFLGSVIILAAAIFAIISVTTHTGITAGMVGLAMSYALMITQSLNWIVRQTVEVETNIVSVERVLEYANLPSEAPDVIFKNRPTLGWPSQGAVTFNNYSTRYRPGLDLVLKGINLNIKPHEKIGVVGRTGAGKSSLTLSLFRIIEAAEGQISIDGLDISKIGLQDLRGRLAIIPQDAALFEGTVRDNLDPRHVHDDTELWSVLAYPDSWMPRYTKQGQRQLVSMARALLTPSNILVLDEATAAVDVETDALLQQMLRSSIFENRTIITIAHRINTILDSDRIVVLDRGTVAEFDTPAELIRRGGQFYTLVKEAGLLETGTSSPAALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4D431</accession>
    <name>D4D431_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000097">
        <property type="protein sequence ID" value="EFE43394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024012.1">
        <property type="nucleotide sequence ID" value="XM_003023966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D431"/>
    <dbReference type="GeneID" id="9582704"/>
    <dbReference type="KEGG" id="tve:TRV_01844"/>
    <dbReference type="HOGENOM" id="CLU_2456384_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="89" mass="10120" checksum="A5F09352482766BE" modified="2010-05-18" version="1">MKKKRIRNEKEEKKVLQNSSGENILGLGQAENRRPKEGMGGIRQEHTWRHQEVGINVNVRMGIANERSNGQEKKGDKAIYGQSIKYTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D435</accession>
    <name>D4D435_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023987.1">
        <property type="nucleotide sequence ID" value="XM_003023941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D435"/>
    <dbReference type="GeneID" id="9582680"/>
    <dbReference type="KEGG" id="tve:TRV_01849"/>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000281">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000008">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="329"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133610" checksum="A0280161029B0937" modified="2010-05-18" version="1">MISLRSSKRKAAQDNGGNNTTNIGNCPEIPEGSVQEEVEEPRPRHSTAEAGHATESSSISLDQSVRTFRLFEVLRSGDTNAITKAVKEYQESGGQEGATLGTSILHLAIQCADPQVVEFVLASVDDAGINARDREGNTPLHLAAQLGRLPVVRELLERPAINDAATNFQGQTPLDLARNPDIFQHLQLARSLFVDTKTREIQSLVGQEDYEKLERVLVEPRVQGMVDMNAPELVTDRTTYLSGGTLLHEAVRKKDTKLIQVLLMHGADPFRRDRKGKLPQDITKDDRIRSFVKKSPAAVMAQRGIQEKAILGNNFAQGSGEVFIGGKDAREIKGYLKKWTNYTTGYKLRWFVLEDGVLSYYKHQDDAGSACRGAINMRIAKLNMDAQDKTRFEILGKSSVKYHLKANHVVEAKRWFWALNNAIQWAKDEAKESDKRRTKDVEVLRQAKMEQIERQDQDTMPTAGNKLNDKTLAPPAASLGSTTTPSGSKLSLQISRGGTDNGFGDDEGSVTGFNDLSTSQSNMARVISHVTTNTAEGDGEDDYADYTSSREMRPASDKDAFSITAQSVRLQLDILRGVSSAINAEKAKNPSVTLSDPTIAQGLTTYGRAVDTLNSLIVDLLKISRDRDAYWQYRLDREADARKMWEDSMARVAREHEDLQNRMGESEDKRRRTKKALREALENVSVPQSRRLSQTVPSSQVRTSDTVEVVQDSKEEKRPEQTEEAPSPVLSRKKTVLEEMNLSDSDSDDEEEFFDAIDAGDVEVVVPTKEEKIQLDESSARAKKELEIAPSFKGYEDEIRKRLKMEADDRPKVSLWGILKSMIGKDMTKMTLPVSFNEPTSLLQRVAEDMEYTDLIDAAADCPDSLERMVYVAAFAASEYASTIGRVAKPFNPLLGETYEYARPDKGYRFFVEQVSHHPPIGAAYAESPRWDYYGESAVKSKFYGKSFDINPLGTWFLRLRPASGGEELYTWKKVTSSVIGIITGNPTVDNYGPMVIKNWTTGEVCNLDFKPRGWTAASAYHVSGKVLDKDGVPHWSVGGRWNDKIYARKLSRDASLSASEITPDGNSPHAMLIWQSNPRPTGIPFNLTPFVVTLNAIPDNLKPHLPPTDTRLRPDQRAMEDGEYDFAATEKHRVEEKQRAKRRDRESKGEEYQPKWFAKGVCETTGEEYWVYNGSYWKSRAARDWSVCEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D491</accession>
    <name>D4D491_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock protein/chaperonin HSP78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023964.1">
        <property type="nucleotide sequence ID" value="XM_003023918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D491"/>
    <dbReference type="GeneID" id="9582657"/>
    <dbReference type="KEGG" id="tve:TRV_01906"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="202"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="603"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="775"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="415"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="96832" checksum="843302F92DF0322D" modified="2010-05-18" version="1">MEGKKRKEEEKDFFPSERSGDRGGRLPWATRRELGGELHGWDRTAAFWSLREGPSTRGRPSQRLDIIYIYIKGKAWYVGLQQVKAHTMSCRLVMRGSRQLLQAPRAAAHINTTARRGLYGLLPRQLSKQYVPASGFVRHYANGRPHPPGGTHRMNLGGEPEKPALEQFGVDLTARAKDGKLDPVIGRDAEIHRTIQILSRRTKNNPVLIGAAGTGKTAVLEGLAQRIVRGDVPESVKNKRVVSLDLGQLIAGAKFRGDFEERLKRVLKEVEDAQGGVILFVDELHTLLGLGKAEGSIDASNLIKPALARGDLQCCGATTLNEYRQIEKDVALARRFQPILVEEPTVPDTISILRGIKDKYEVHHGVRITDGALVAAATYSNRYITDRFLPDKAIDLVDEAASALRLQQESKPDAIQELDRQIMTIQIELESLRKEKDIASVERREKLEELLKTKQEDVGKLTEAWDKEKAELEAIKQAKEDLERARGELEQAQLEGNFAKAGELRYSTIPNLEKKLPQEDDTGSTGTQGQSLLHDSVTADDIAGVVSRTTGIPVNKLMSGEVEKLIHMEDTLRKSVRGQDEALEAVANAVRMQRAGLSGENRPLASFMFLGPTGVGKTELCKKMAGFLFSTETAVIRFDMSEFQEKHTVSRLIGSPAGYVGYDDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGFLTDAQGHKIDFRNTLIVLTSNLGAEVLVSADASEGEDISPEMKSAVMGIVQSSYPPEFLNRIDEFILFKRLSRSALRDIVDIRVKELQDRLDDRRITLSVSDEIKDWLCEKGYDPKYGARPLNRLISKEIGNHLADKITRGQVVSGQTATAIFNEDKTGLDIATEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4B7</accession>
    <name>D4D4B7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase type 1 complex subunit Hex2/Reg1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023882.1">
        <property type="nucleotide sequence ID" value="XM_003023836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4B7"/>
    <dbReference type="GeneID" id="9582514"/>
    <dbReference type="KEGG" id="tve:TRV_01932"/>
    <dbReference type="HOGENOM" id="CLU_020417_0_0_1"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="463" mass="51792" checksum="74C723A521ED7D20" modified="2010-05-18" version="1">MACRAADDSFVEREPSRHVDYLSHSWREEDVWSSWRYIAARKDEYESGHRLENAAWRSWARIRFGLGWFPAEALNWQKDIDVTWLYGPLQVPGDETDDRSSTASPTPSSPGASNSSLIDKKPILKKRTISQSILQRPHSTHTFLRLANALIKAQDGADGRYIADYPVSRQEVEKSLGLPSESSVSNFFFQESRGDIPDKRHISFSNEVAQCVAVEDDDEPFDGEYYGYYSYATDGSVVEEDEASDDGVVMARYYPERPPLSFQSTPRSSFSSDSRIIAHLPSTTLKYRPDTPEPKQETPRPVRPTLSRSSSAETLRPSNYHAAAARTSSHGDFFLDEEYGADEDWNTGWDIEWNAQQSSSMNQTSSPPSSSTITTSASLPSLASQWFSNSKAKASISEEGKYYSSSGVFMPFGYGDNSPDGDLDGPEETEETNSSRGVIDRVIDTVNTARDIAHVIWNVGWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H0</accession>
    <name>D4D4H0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein (Ish1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023865.1">
        <property type="nucleotide sequence ID" value="XM_003023819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H0"/>
    <dbReference type="GeneID" id="9582476"/>
    <dbReference type="KEGG" id="tve:TRV_01986"/>
    <dbReference type="HOGENOM" id="CLU_022672_1_0_1"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055232" description="Stress response protein (Ish1)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56714" checksum="71387BCE6087C57F" modified="2010-05-18" version="1">MKWLLTGLIIALTVSEAVGSRDWFSKAVYNKWHETELERWLSDHDVPYPSPADRKDLEELVKSNWESYVAEPASKTAEEISGSFNDAKEWIFDSWSDSQLKAFLDRHGIPCPQPKKRDTLLSTARRNYEAIAQKLGQSVNYPGNWLYEHWSESELKEYLDSHGYPVPQPTTRDKLIAAVRRNSRRAGIEGQKSAAAASASMAAAQETLAEALFNAWSESDFKKFFDEHGIKVPQGSKRNELLALARKHRQALLEKPSASMASVYGAATSKAGNEFARATDDAQLKMEDAFNQAINGWSNTRLKAYLDARGIPVPQSDKRDELLAKVRLHGHKAASGYTAWTFDTWNKENLGKYLSSQHKKALEGVEYTRVELLKQAQDAYNRASKTGGPDFTSITNYLAQVTGSMKDTNFNTWSKDDIENFLASYGIKPTRGSSIEELRRQAKDNADYFRYGITRQEASMFSRLQSLGQWAWDQLKIGALSGRAEGQKAAQEVKEKATKANDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4L1</accession>
    <name>D4D4L1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023831.1">
        <property type="nucleotide sequence ID" value="XM_003023785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4L1"/>
    <dbReference type="GeneID" id="9582406"/>
    <dbReference type="KEGG" id="tve:TRV_02028"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000038">
        <property type="entry name" value="Probable 2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="157"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="307"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="50952" checksum="596EBE05ECFD4950" modified="2010-05-18" version="1">MNTSKRLWARLRSFSSINETYPRVYTHTHTWKTKMGSIHFFSTGRPLQHSSSNNNNNMHKKIHIMGVGNIGSFVAHSLAARPVSERACITLLFHHPAFYKDWNRFGRVVAVKRHGIPEQRSGFCINVLQDHQWYYPSEIEGAPNDLVEEEFSLRQGKEADSDGNLTPADEEGIEHLIVTVKTTQIERAMKSVRHRLTPESSVLLLTNGLGVLEEVNEKIWPDESERPNYLFGVTSHGLFKSGLFETTHAGVGATTIGVVRQSPRDDIEDTADGSSTTFAPSTNFLLKTLTQTPELACISTNATDLFLLQLEKLAINCIINPLTLLMDCKNGELLYHYNLTRVQRLLLIEISAVICALPELQGVPGLQSRFSPERLRTIAVGVAGKTGENTSSMLQDARMGKESEIEYMNGYIVRRGEEVGVRCALNYMVVQLAQAKSRIAGRQRNEEVPFDLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D510</accession>
    <name>D4D510_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023671.1">
        <property type="nucleotide sequence ID" value="XM_003023625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D510"/>
    <dbReference type="GeneID" id="9582218"/>
    <dbReference type="KEGG" id="tve:TRV_02179"/>
    <dbReference type="HOGENOM" id="CLU_033922_0_0_1"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="571" mass="63628" checksum="4A703FC4D333DB57" modified="2010-05-18" version="1">MTSMAGTFTLALDPTTHFGFSEDGSHTDYELAISPRSDDIRAMLGSNDFPYDLDAAGVMNQKQNMTKAQPLTGFEQCASAFPANPQRDVEIYNSPYHMETTIPWETDCMMYTSLPQRMVRYTSPLGSCGGDQSTSDSSMSEYSWNSPKLYPSVNDVFDSPITEKCQFSDGIDNALSRSLSGSQLGSECSVSSKDVQHYPDPVPTQSPTFEELMLSNKPPRSIPAFMSQSFSLQNLDSRLGQDDMVFGDHLQTGNNEIVDPALGEAYFDRQNSLSGITSAGFSGLVHKRVKYNEIKADSSVSIPSPPLSPSGSESGVRKNRAKPKQRQSPVSKRTTRRTPSKSSSFSIPRNRQSAADRIFSCVFAPYGCTSSFASKNEWKRHVLSQHLQLGFYRCDIGHCKVSKPSNSMVSTPYSCDCPASISSSPSHSCTITTMRTPNDFNRKDLFTQHLRRMHAPWLTLPSPHEPTKGEREAFDKQLDEVRARCWVQQRQAPQRSQCNYCSHEFVGPHSWEDRMEHVGKHCEVMDTEEREDVALREWAIEEGVILPYGPGKWLLASILNGSGKKFCGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D522</accession>
    <name>D4D522_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_02191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023683.1">
        <property type="nucleotide sequence ID" value="XM_003023637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D522"/>
    <dbReference type="GeneID" id="9582230"/>
    <dbReference type="KEGG" id="tve:TRV_02191"/>
    <dbReference type="HOGENOM" id="CLU_003637_1_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="241"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115921" checksum="7C8FE0B4C7258E6B" modified="2010-05-18" version="1">MDEETQPSTQPYADPRRKGVNNSGLSQQDVADIICILHPNSPAAHKSASITADRNPQHILQRDEFDSDLDACESTYDIALRFSSLVKDPSMGFCFGRSSTRSDIIFYPDHRVSNTHFRIYLKTDGILMLQDTSTNGTIVDGKSIRRDGGDNSPTTQMLMSGSVIHVTGNDLASAIKFVVRIPARDELQAQYTRNLTWYLNRIRQLSTKVGDVGRGEMPAPGIVVAHTNHSHGMHWNGGAKYNVTGQIGKGAFATVYKLATKNDGAVFACKELDKRRLTKNNVLDHKVDSEMRIMKDLDHSAGLLPEDQVQKISRQLLHALQYLHARKITHRDIKPDNILISSYDPFIIKLSDFGLSKVSQEETLMKTFCGTLLYCAPEVYPEYDTYKHHLPRKRRRPGDPLPRTSPYDQSVDMWSFGAVAFHILSGHPPFMGRGDDRGAQMLRNIMTTEADYSLLENVGASEEAIDFISRLLNRDPKARPKEPECFRHPWIAEVPDEFEYEEVGEPIQTGPLTELIAVPELSEEEDQDDKDVWARAWSLERELEDKREAYYRQQDVEAEQRLSSSDQNANAKKPRVTLEQDIEEKHVQHVDDVRYPSLPQLSSYQYEAKAEVKSSPNGPRLFGEITPSLIKSSGVLGEDYSEDMDIAGLGEDDADDSSDQYVISNEGSSLSKDIFAEVGQPHPPLTMRPPPPPKASDPSLMGAESLVGHLHMRSAGQNGMASGGRSDDDTDIGKPLDGDSQNSKKYASSNGTAKGNWAELKVGTGPDPFSSTNRHSPLGDKLTSYRSVPRDMNSSVETDKPRSPAPSERTGNQDEIPNELACTIDERTGLEVPSQSQPNQDIDAHAEEDKEKGNGFVKPVAILGKLTPLPGSILDQPIRLESRMTSWGRGTQATIRHPDSMDFRIPSYALELTFWAPSIEARIAAGEDWLQMTDVVTLISTKTSQCIWVNDVELRKESRSKDAFLFGRIYTGDIITVYRSKDQFLRFRCEFYHGKSRLERPAGEKRFLIEESPKSYCNTRTEGNPASKSERSPVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D592</accession>
    <name>D4D592_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor (Con7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023515.1">
        <property type="nucleotide sequence ID" value="XM_003023469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D592"/>
    <dbReference type="GeneID" id="9583535"/>
    <dbReference type="KEGG" id="tve:TRV_02262"/>
    <dbReference type="HOGENOM" id="CLU_030366_0_0_1"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="461" mass="49858" checksum="B8BD2E0AE75F283E" modified="2010-05-18" version="1">MDRPASDYAQAGLSPQYPSLPEAQSEQSTADQATASAAVASPTQTEARRTPQSQYSAPPEPRSGGISASNTPQPDYNLHQNSSHPPPPPAAARPSPYPEYLTRQPQYHHAPHTQAGGPPGMAQATSPSMNPQDGQQSDHRSPAQVKSDTEVPIDPSIAASSPSYPPPYSPYAPQSHDMAQYQSHPPQMYARPDWPHQYGAHQPGMPGPYSSPASVSSASPAATAGPRPGQVFSFVPIPGSQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRSPDGLYSLFILLSLCLIEATLYFPCRLPAIYPLASLSLCNRSLGRCSKPASWWKFKEIRKEWKARKKEEDNQRKAAEERERAAAQANQVDSNGAPSGSGQPSQPTTSYAAGVRPQLPPIGYQPADGQVPGQYGAPPGGLVYPPGNGQMPATYSPSYPHSPYGQGSQVYPQPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5G1</accession>
    <name>D4D5G1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02331</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023584.1">
        <property type="nucleotide sequence ID" value="XM_003023538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5G1"/>
    <dbReference type="GeneID" id="9577056"/>
    <dbReference type="KEGG" id="tve:TRV_02331"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="14">
        <location>
            <begin position="125"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40635" checksum="A19B8D6B40BB978D" modified="2010-05-18" version="1">MVANTGQPGEHTFYLYVREKDTRAELWEGARSGTQAAMDVFNADESGDIDHLKDYLPEILSGASEIYTDISAGRGRSAFSRFISSFSDSASSASDAREEAMEKIRPLSPIINELRVFKSDAEIANMRHAGRVTGRAFTESMRHGFGTESELDAFLEYQFRRQGGDGTAFVPVVAGGSNALSIHYVRNDNVLRYVPWLLVQYAGYISDVTRVWPVNGKFTPAQKELYTAVLNVQRSCISLCRESAGLSLDKIHDIAERSLREQLDSIGFNTSGGLQAMRTLFPHHVGHHIGLSVHDCGGYSRQEMLRKGQCITIEPGVYVPNDERWPEKFRGIGIRIEDSICVGDDNPIVLSPEGVKEVRLVVITVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Y4</accession>
    <name>D4D5Y4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWI-SNF complex subunit (Snf5)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023405.1">
        <property type="nucleotide sequence ID" value="XM_003023359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Y4"/>
    <dbReference type="GeneID" id="9583425"/>
    <dbReference type="KEGG" id="tve:TRV_02507"/>
    <dbReference type="HOGENOM" id="CLU_018784_0_0_1"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="94892" checksum="09E343DF3439EEA8" modified="2010-05-18" version="1">MPWPEAEENTGQPDGALQGSHSHSHSPQPVAPAAGSSEQPAESPQDQQLAPGGHNGAIPAGILEGKQNARAIMGASELPDGPAHAAEGGGEEGSGGGSGGGGGGGGGGGGGDGDGDEPARQGGASSPSPQETSITNGNGVSRKRSRSGSIIQSTAAAPASAAAAAAASPVIEDDGLPRKTPLEKVLLEDYLYREWGHSALAATRNTHQEVLRQKLQERDYYLALNQERQANPAAIFGPGYEGYGNTRTDLRSQHPQLLYPSNRRRPGGRKAKELRIPREDMLTQSDQDEHLVPIRLDIDWEKVKVRDTFTWNLHDRVTPVDVFAEKLVEDLGLPLESCGPLVRQITQSIHEQLADFYPQVFIEDEPLDPHLPYSAYKNDELRVLIKLNITIGQHTLIDQFEWELNDPHNSPEGFAIQMSQDLSLPGEFTTAIAHSIREQVQLFTKSLYVVSYPFDGRPIDDPDLRDAFQPSPIPSTFRPFNVAKEYTPYLYELNEAELDRTEGSISREQRRQKRVNRRGGPILPELKDRQRTIRTMIVSSVIPGCASSIEESRLFKRSSTSRRGRTSTGHRDGLEESESSESEESSIGSPAMSRLNQGTARTRGMRQASSMAQSAIRGQMGRSATPETTVSHSHETRTSARRQNYREESSEAPENLIVKLKINPDKLRRLMRDLKSGSRQYTGSPGGPSSTPTGKSSARGSMGPPPSQGQPGSATKKPTNPPQFHGVIDAPHPLPPGTQPWLIQGLVGLKRQYPNDSFEGTMRYTAVDPNTNLPIPNAAQTHPGQKLPYKYFPRIRCNDCPGKLYTPGPAMTVENFEVHLKNRNHKEAVAARLAREKGGSGPPPVRRTPSNSSATKESSAPTGTSTSAGNDSSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6A2</accession>
    <name>D4D6A2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000135">
        <property type="protein sequence ID" value="EFE42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023236.1">
        <property type="nucleotide sequence ID" value="XM_003023190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6A2"/>
    <dbReference type="GeneID" id="9583260"/>
    <dbReference type="KEGG" id="tve:TRV_02626"/>
    <dbReference type="HOGENOM" id="CLU_2387753_0_0_1"/>
    <dbReference type="OrthoDB" id="10488263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="94" mass="9858" checksum="BAB843A1E8BE15F9" modified="2010-05-18" version="1">MSNPEQRAYEVEMAAAMAAAEAEAAAQAQAEAEAEAQAAAQAEAEAQAAAEAAAREQARQDSAEVTRGLMDPVTIRQLSSSGHFAQRAREGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6B4</accession>
    <name>D4D6B4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000137">
        <property type="protein sequence ID" value="EFE42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023223.1">
        <property type="nucleotide sequence ID" value="XM_003023177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6B4"/>
    <dbReference type="GeneID" id="9583247"/>
    <dbReference type="KEGG" id="tve:TRV_02639"/>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="559" mass="61403" checksum="55123BE452F7763E" modified="2010-05-18" version="1">MAESYKARKEAFVSNLSGSSVWDIHTVSAVVPSAVLLWSVLQSRRSLFTPYELPAVIADFLLTVVTVLFAVTAYSSSPIVLNILLLSPAALLLLSTKPKNVRQKAKPPPGSAKSTTHQGQGSSDAALDALPQRPFLTHYRASLMISTCLSILAVDFTVFPRRFAKVENWGTSLMDMGVGSFVFSGGVVSARSILGRGSAASQGSFAKRLLASARHSIPLLVLGLIRLYSVKGLDYAEHVTEYGVHWNFFFTLGLLPPFVEIFHAMTALIPWYEALSLLVIGAYQVALESTSLKEYILVSPRGPSLLSKNREGVFSFLGYLAIFLSGRAAGLRIIPRKPRRTLLIQLVSWSAVWATLFTLNSSYFFGYGAGIPVSRRLANMPYVFWVNAFNMTHMLLYCLIETVVFPSVEKVSNKKEEAEQSDFATSRVMRSFNKNGLAIFLIANLLTGAVNLSMNTLDARKELAMAVLMLYSVILTAIALALDFWNLLCYLVTFELSESTKLRDGFFGRGWFALVDSSAAMAAKVNCLTSFQTEGIVTSRHPLTNNNNNSDDDDDIDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6K4</accession>
    <name>D4D6K4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023151.1">
        <property type="nucleotide sequence ID" value="XM_003023105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6K4"/>
    <dbReference type="GeneID" id="9583159"/>
    <dbReference type="KEGG" id="tve:TRV_02730"/>
    <dbReference type="HOGENOM" id="CLU_047042_1_0_1"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="260" mass="30097" checksum="801220A8EC65343D" modified="2010-05-18" version="1">MTLTHNKLHANQIYERSYFQNGQSGTAQEKTAAVNKIFDKYRDDPDSPDEIGINGAMKYFGDLQVRLDEVACLAVAELLRSPSMGEFTREGFVEGWRGTTESASLKPVYSALIYSQLSRCDTIEKQASYANGLRKLLLDDPNYFRRVYRYTFLLCRMQGQRNVNIELAVEQWQLFFTSENGGVAWETKSVPWLKWWIEFIETKHKRPINKDLWEQTEVLMRKTMEDESMGWWSPDAAWPGAIDDFVAFVKEKQGATAMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6L7</accession>
    <name>D4D6L7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023123.1">
        <property type="nucleotide sequence ID" value="XM_003023077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6L7"/>
    <dbReference type="GeneID" id="9583143"/>
    <dbReference type="KEGG" id="tve:TRV_02744"/>
    <dbReference type="HOGENOM" id="CLU_024064_0_0_1"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="84286" checksum="F4947C3BACE2733C" modified="2010-05-18" version="1">MALPQLYKNLTLTSYGQIRYNEDDLPEGYGSASPFSMGLNALVTRNVAPLVRSITLRGEWREDGLEEHARVGRVPDSSMMLNICVRAAIDKMAGLESFRYAVVIAICNNLTMFSTLDWEISNTKALETVCQGLAQLQNLQSLTLRFPSSRHPRPTTIIPPMPNLRVLKVTDIDPLCYPDDISLLLFGSKKLCDLRMHWSPRMRESQEPSVALSDYFRRCISAKSPLRLKKIAFQNFFALHPGESGPGVTHSSLEEITMLTNSSENAAMTFVEASWPAPGPREEMSMLKTFRVDRVEKRGIDFLHQLSPLENLYFVNPLREPIDYVNNSRPGVSYQPSPSTTNSSGGNQSMASEYQQNHPTPPGPGIQPSTSRASLREMQVSTIISVHGATLKRLLLPARMNMPVPLVVKLVHACPNLEQLAIAVDGNSLEVMGIVLPFLKKLEALRILIPTLQDNDLRSTTPTGNVRTCGRGQSGINSNIINRSHKSNCFPRPDLSLLPPSDSRDLARLVDINDSFHIQILSLHLAEPIYNNIKIVGIGWKAWQIGGLYKESTPTRNNTPPASGDTSNGNGTIADPPVGVSNSNTNGHMPSNLMNTPLMRPESYGPDSSNPPAWPTQQQQSISSPPENRNPLGKRKYNSQQNSSAPLPPPEEAYTPIMEPIAKKQQQNRPSAGSNISSGHPNIPENTTNGNEKSAFPALSFLDEQVFAQIPENLRQSLNDCFTQVRGNADQPFVWKRHVKRVGWDVLKHWEIWGLDVQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D784</accession>
    <name>D4D784_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-3-phosphate phosphatase (GppA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022916.1">
        <property type="nucleotide sequence ID" value="XM_003022870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D784"/>
    <dbReference type="GeneID" id="9576954"/>
    <dbReference type="KEGG" id="tve:TRV_02964"/>
    <dbReference type="HOGENOM" id="CLU_045011_26_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22838" checksum="546C71059A36DCD9" modified="2010-05-18" version="1">MLKILAPEKATWECESSHQHISAVFPPIGYPRGGAEKEGGEEKKKIGRTRKVNVSMIEGRIPKDLGNHATEIPGARRILTSLEEAGAPWAVVTSGSNALITGWLGVLQLAHPKYLVVAEDVQVGKPDPSCYLLGRSRLGLEHSDSMLVIEDAPSGVRAGKAAGFKVLALATTHVVEELKEAGADWIIKDLDSASLKKFADGKVEIEVWDTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7F5</accession>
    <name>D4D7F5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oligosaccharyl transferase subunit (Gamma)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022813.1">
        <property type="nucleotide sequence ID" value="XM_003022767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7F5"/>
    <dbReference type="GeneID" id="9581537"/>
    <dbReference type="KEGG" id="tve:TRV_03037"/>
    <dbReference type="HOGENOM" id="CLU_052855_1_1_1"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38272" checksum="827F84214F681F50" modified="2010-05-18" version="1">MTPFRHLRALVNRNDRITPNMRLFSLILCAIWPIALALGASSKAGDKYSKFKTASRSTGAVTLDDASYHELTAAPRDYHTVVLLTAMDSRFGCEICKMFQPEWELLSRTWSKAKLGDSKLVFGTLDFLDGKGTFQQAPITSQLDMTSAGECEFKGSEGMNSELNDASSSPVTAEQMHLWISRHLAGVPTPKLVRPINYTRMMGMLIGMLAVISLITVSSKYVVPILRSRNLWTALSLLAILLFTTGHMFNHIRKVPYVAGDGKGGISYFAGGFQTQFGLESQIIAAIYGVLSLGSIALAMKAPRILDPQSQRVTVILWSAVTWVMYSFLISLFRVKNGSYPLSIPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7P2</accession>
    <name>D4D7P2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation repressor/antiviral protein Ski3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022744.1">
        <property type="nucleotide sequence ID" value="XM_003022698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581434"/>
    <dbReference type="KEGG" id="tve:TRV_03126"/>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="159237" checksum="3AB2DAB8FC025C07" modified="2010-05-18" version="1">MAPKSALKAIRADLDAGDYSQAAVKASELCTQDPKNYHAEKLNEYDASEKAYESAIKIKDSDKTAWQGLVALYESQGRKRLEAYETAVERLCNIFADTYAYLLCLLKYNDEMTNPFASEEYGRAHGVLEKYINFVKLHGSKLQYIHALQLRLPTSPIYKCVEGLAPRPSETYLRVAELAEQEEKEFINREIGERRTRLGARIDQVTTEVKREAFNRSVLNELYQGIIDWTHDDETRRYYEEKLLQRHYDHLRILPSKEKPTGRELVVKAARDMVIIKHPFELAWRITFDWTDTEELSSLDVTLLRDFIRLFPDHGLSKILNGFLYTNLSPFPYQNLYNDVDGTNTTENPEIEAQYMVADHLLIMAEGLDQASDSVLAHRIMGAVYSHLGEFQTVIKVSRSGLAINSTIRHDTGLKLQNIDDSLNILLATALIPHQSPRHHPEAKAIFQDILSRKPQEDNCLLGLGLILEESHDFAAAMDLLAQALIRDENNAKVRSELFWCKVQNGELAAALKGFEETLPLVQCPGSRWHNLRAEVLYRIGFCEWELDPSPSARKTRNGAYSKFLAAIQADMNYAPAYSSLGVYYADYKKDKKRSQRCFHKAVELSSSEVMAAERLAREFAAQGDWDLVEAIAQRVVDSGKAKPSPGSKRPGYSWPFAVLGVVEINRQLYAKSIVHFQTALRISPNDYQCWVGLGESYYNSGRYIAATRAFRNAQSLECTLPESERGQIWYSKYMMANLERELGNYAQAIMMYEDVTHLRIEEFGVSVALLQTLTESAWKAAESGFFGEATETAKRAIETGLSITNYHPNGFNLWKSIGDAFSIFSWISNKSSYLPIAPFRAVLKTTCDVTAFNILSNLDGIGENFDTLFESLLGSNETAQVISIYSTILAFKYALSATAKDTHAQALAWYNLGWAEYRAHMQRSSFLKGPRSNKRTGFIKAATRCFKKAIELEAGNADFWNALGIATASQSPKVAQHAFVRSLHLNERNAFVWANLGAFYLLNDDYQLANEAFTRSQSADPDHSNAWLGQGLLAMLIGDAVEARELFTHAFGLGNSSGAFAKQQYAISMFDDISSSPEPTPAQLLQPLFGLRQLRSVDPSELFHYHLSSLFAERTGDLEDCISDLETVCSGVEAAYESTESIGSLLKYAQASADLARIQLGRLEYKEAADSAETALNLMVEEGIHECHGGLYQVIRLSAHLTAGLAFYYLGRMDESIEMFRDAIQGANNSPDVTCLLAQVLWAKGGDEERLVAREQLFECVEKYPEHVGAITLLGVIGLLDTDEDTIEAVESDLQAMRARTDLDTHSIGKIVKLLASIPALRYEAEAEATRTSEMLKQATTSVMISPSQPQGWMALSSVSTERYAAEMAVRTALVSIPPRGKLDAEALCQAYSLVGTRKSALSGVMVAPWSKNGWDELIQCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z3</accession>
    <name>D4D7Z3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Gamma-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022640.1">
        <property type="nucleotide sequence ID" value="XM_003022594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z3"/>
    <dbReference type="GeneID" id="9581299"/>
    <dbReference type="KEGG" id="tve:TRV_03227"/>
    <dbReference type="HOGENOM" id="CLU_092556_0_0_1"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="221" mass="24764" checksum="0BA315293F86216C" modified="2010-05-18" version="1">MSASTTTLRYPGYMHNDLVSVIASLIPIPRAHFLITSYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMMSITPGKSSCYISILNIIQGEADQTDVHKSVLRIRERHLASFIPWGPASIQVAIPKKSPYLQNTHRVSGLMLANHTSVATLFKRIVSQYDRLRKRNAFLEQYKKEAPFADGLGEFDEAREVVMDLVAEYEAAERPDYLGGGAEGDHGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D809</accession>
    <name>D4D809_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022587.1">
        <property type="nucleotide sequence ID" value="XM_003022541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D809"/>
    <dbReference type="GeneID" id="9581252"/>
    <dbReference type="KEGG" id="tve:TRV_03244"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_1_1"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="298" mass="32000" checksum="F25A0C1F14404E39" modified="2010-05-18" version="1">MAMCIGSSVAELVSAYPTAGGMYFVTKHVVPKEQVPIFAWIQGWCNLLGQTAGVSSVAYTVSQMLLAAASMNSNLDDDGNYSFKPNKTIDGVYNRTALQTVLLSIALLCIMGIICSLTTKSLHRIILWFAPINILASIGICIALLVLTPNKQSAHWVFTNVTDGSGWHSKAFSFLLGFIAVAWTMTDFDGTTHMSEETHDAAVRGPVAIQTAVVVFGAFGWMLTVTMCFCITDLEAVLKSPTGLPAAQIFLDAGGKTGGTIMWSFAVLVQFFTGCSAMLADTRMAYAFARDDALPFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D820</accession>
    <name>D4D820_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spindle-pole body protein (Pcp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022598.1">
        <property type="nucleotide sequence ID" value="XM_003022552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D820"/>
    <dbReference type="GeneID" id="9581257"/>
    <dbReference type="KEGG" id="tve:TRV_03255"/>
    <dbReference type="HOGENOM" id="CLU_002168_0_0_1"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="714"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="959"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1244" mass="143549" checksum="EC674855DB8D627C" modified="2010-05-18" version="1">MAFPYIDTPRTEVDGNATFISQGQRSATRHNLSALDSVENSFVSPTKDHDILRETSDSRNRQRRVSLRTPRASQILKSARLDKRTLPNSALPKGEFTPLMNSVTKNNFLRTGGDRARGVPATPALSKIDESNIYEGASMNSSAYDATPVPQGAPSSGQSTPLPTLPQRDGAGGIINKFDKENFGLKLKIHYLEEQLRKAGPELNQAALKENTELKVSKLTVQRDLHRCKKSLIHAERDLESCQLQLQELRAKLTSKQSDGASQETIKWMRQEMESKDADIADLQEQLRSAESKRAEEAANLREEINELEYTIREKDRHIEEKEEEIDNLQSKHADENANMADLETELEDARSKIEDLQDSLERARTETEDAETACEQALQEKEQAVEDLRELQDEMANKSISASGLTRQLEERANKLESELTSVRQQYVTLQEKLDEKAQFEHRLQEQIKDLRQENSSTERELIFLQKEHASCQGNIEDKMHSENRLQERIEDLKQELSSAKSDLQHELEQARHEKAIAIRDQKSTLARLQALEDELQHKGETKTLLQTRHDALTNESKALQGDLDRAKRVIAELEEDAAAERQESLNTLEEMRNRHKDEIDRLNLQITTLRREVDKKDSLFNSDLDKWENIKRSLELERDRALQQAEAHKRTVDSLQQMETTKSGREKRLQDIIDSEKQRRLQQEELLTRQIKELNDDISSRREASETQRSELLSLKEQLRVSRREEQTLKEKVQGLEDEIIVLQASLEEEQQYALAQRKAGSLDTGGHLQSIAQEKQALREELTATKSALNELRVTLAEVEAERDGLQDELAQYDHVGDATRVDHEKLELKKAKLRLERDVIRLNTEKISLQEAKDALQNEVDNELVRAAAEEERLAAEISRLQDKLFMADDKKDRELLSYRSKTTRLEARLKELEAHLHNPVPPEPASPPDHADVSIFRQCLAETRERERIILQRESDLKSSIRLLKTRITDLEKENHDLQIAKYEGSSPIPSSPASRLEEELRNLRAQNIEAHKALKELKAKNRELEQQRYSANEESQNFSEVLDLSTFDPESIAAKLSRREARIRELEGDIQRIRGERSTALKNLNAADRRIRLLQDRHPKAIQDMSKQLEKQKSRHDRELEVLRMELLWNQVRLIRAEQFRRDLAWYKEVSQYREQERIRTTCAQIERQMIANMGIVVSEATEQLSPIQKFRAGISVALFIARAKRVTIEWKKNSQIGDLVKRAKKDQHRKHGRVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D884</accession>
    <name>D4D884_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000171">
        <property type="protein sequence ID" value="EFE41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022558.1">
        <property type="nucleotide sequence ID" value="XM_003022512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D884"/>
    <dbReference type="GeneID" id="9581216"/>
    <dbReference type="KEGG" id="tve:TRV_03320"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33396" checksum="B87FAC74A2D24AF0" modified="2010-05-18" version="1">MPQPSFATCTEVGPACPVVATTYGYYPQLGSNAFLTAFFAFLALVQLGLGVFTRTWSFLIALFMACALEAIGYGGRLLMNKNPWSKDAFQIQIVCLILAPTFLAAGVYLTIKHIVIFVGPEHSRIKPKLYTWVFILCDIGSLILQSVGGGVAAAATKSNYKLLNVGNGIIIAGIAFQVATMSVCGLLALEFFIRAFRSGKGFSSSGLPHGAAARKSFWIFCAADAFAYTAILIRCIYRLPEMAGGWGNPLMRNEKDFLLLDGMMIALGAATFTIFHPGFWFPPMRKGGAGSKDLQGIPPSEGTSVNDAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8A5</accession>
    <name>D4D8A5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alanyl-transfer RNA synthetases family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022542.1">
        <property type="nucleotide sequence ID" value="XM_003022496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8A5"/>
    <dbReference type="GeneID" id="9581119"/>
    <dbReference type="KEGG" id="tve:TRV_03341"/>
    <dbReference type="HOGENOM" id="CLU_004485_3_0_1"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000018">
        <property type="entry name" value="Alanyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="265" mass="29206" checksum="E74A06D6835A0DC6" modified="2010-05-18" version="1">MARTLLAFQHHAKLYTLQTLVTAMRPFAALEEANRQLFKQGSEEDHVVVTEKTIFHPQGGGQPSDIGMITSPSGSSFTVTSVRMDALQDGQVLHFGRFGPSTFAPGEMVQQEIDVEKRLLYSRLHTAGHVLGAAVKHLVEKEVEGFEELKASHFPDSAACEFRGLIEGKWKPSIQDKVNEFIAAAMPVEIEWWDEDDFRSRGLERLIPDPTLVPPGEKSRVVNIVGAEVYPCGGTHVDSTDLCGQTTVKKISRSKGTSRVSYTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8A6</accession>
    <name>D4D8A6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ergot alkaloid biosynthetic protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fgaFS/easG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022543.1">
        <property type="nucleotide sequence ID" value="XM_003022497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8A6"/>
    <dbReference type="GeneID" id="9581120"/>
    <dbReference type="KEGG" id="tve:TRV_03342"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_1"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019901">
        <property type="entry name" value="Ergot_alkaloid_biosynthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03649">
        <property type="entry name" value="ergot_EASG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="285" mass="31665" checksum="1018E1C4D90F3C20" modified="2010-05-18" version="1">MAILLTGGTGKTSIRLARFLQNANIPFLLASRRGSSAAPVGMPAVKFDWLDKETWKAPFGGKPISAIYLMEPLVAEPWKPMIEFIEYTRNVHGVTRFVLLAGTSTDLSRPGMGVVWKHFLETGVDHCVLRPSWFMENLTDEAPGPLIREYSKIYTACGDGKIPFVSAIDIAAVAFRALTDPKSHNCDYRILGPELLTYDEVAEKLSAHLGRRIEHVKLSGDERYKGLTDAGVSDYFARFLTNLEVAAADGFETHMNNTVEEVRAGHPGAWTTLLMKIYIRGSRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8A7</accession>
    <name>D4D8A7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022544.1">
        <property type="nucleotide sequence ID" value="XM_003022498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8A7"/>
    <dbReference type="GeneID" id="9581121"/>
    <dbReference type="KEGG" id="tve:TRV_03343"/>
    <dbReference type="HOGENOM" id="CLU_2160243_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="111" mass="12335" checksum="4F82D0C472BE6E37" modified="2010-05-18" version="1">MVQLRHHQRCEDLVEWRTNAHSIQPDDTIKEETGNIQHVIAENNNDTIPRVSSEARKTTTIQAKCVVGSDGAHSWVRHQLGIPMEGTSTDAVWGVIDAVFITDFPRAGCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8C6</accession>
    <name>D4D8C6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022520.1">
        <property type="nucleotide sequence ID" value="XM_003022474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8C6"/>
    <dbReference type="GeneID" id="9581096"/>
    <dbReference type="KEGG" id="tve:TRV_03362"/>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="393"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63868" checksum="6F4AF9554FBB0911" modified="2010-05-18" version="1">MRFIRTYNAAAGLGLRGAVRPRYATLPQLRRHYGSQDVAPGGPPQPGKEGPDPDESSREKSSNQQDNSLKATLLRMFESSATTFASIAVLGAAGYSYHKYYKHLVLKKMDNAFEPGDPMLELAGVKDPKQDPKGSKDMEKDPDHWLERDEQGRIDEIINGAIGHYYLLIGEKGTGKTSMILNAMRKVDGSRVAMFEAHANLEIFRIRLGKSLDYEFHEDYIGSLFSIRGPRDTTALLDIERALNKLEKVAIKRRNVNQNPLILIINSLHLVRDDDDGRDLLEMLQQRAEQWAASGLVTMVFNSDDYWIYERLKRYASRMEVIPVPDLPKGKALGALRRYRSRYFKENPPQSILEEVYNKVGGRLTFLNRVAKSEDMIATCNEICEAEKTWFLNKCWILGEEMDDDVMDEQKYSSAAMVLAKALVDLEKDMEKTYDDENGHILPELPLHKARQIMTRADFIQSYDHDNIFTIDSKARVRADSVPMQNAFREICSEPGFDQYLEDTLDRISAIESLGRTREITVKDFWNEGKFKATMRDTKGRETGTLEIGVVKPEKEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8D5</accession>
    <name>D4D8D5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ab-hydrolase associated lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000174">
        <property type="protein sequence ID" value="EFE41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022508.1">
        <property type="nucleotide sequence ID" value="XM_003022462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8D5"/>
    <dbReference type="ESTHER" id="trit1-f2rna8">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9581084"/>
    <dbReference type="KEGG" id="tve:TRV_03371"/>
    <dbReference type="HOGENOM" id="CLU_010974_5_0_1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="442" mass="49637" checksum="5B3F55A62655013C" modified="2010-05-18" version="1">MLTASAAQPIINLCYRQSKRLFHVLSAAQPRRPKQESISGEIAKASEFTELCDLFGYETEEHVVQTKDGYLLGLHRLPWRKGETHVYENSNDVDNEASRKPVVYLHHGLLMSSEVWVCLTEEKRCLPFRLVELGYDVWLGNNRGNKYSKKATTMSPSYSAFWDFSIDQFAFHDIPDSIDYILSVTGQPSLSYIGFSQGTAQAFATLSIHPTLNRRINLFIALAPAMSPAGLSNGVVDALVKASPDVMFLAFGRRSILSSTAMWQAILYPPIFVRIIDTALLFLFNWSGKNISTVQKLAAYVHLYSSTSTKSVVHWFQIIRNKSFQMYDDNAGSKLSIAAKSRFYKPAKFPTKNIKTPIVLVYGGSDSLVDIDVMLEELPAHTTATEIAHYEHLDFLWARDVDELVFPHVFKALSSQTRTAPAKLTEQFDGPADDTCFVDYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8M5</accession>
    <name>D4D8M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022398.1">
        <property type="nucleotide sequence ID" value="XM_003022352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8M5"/>
    <dbReference type="GeneID" id="9580945"/>
    <dbReference type="KEGG" id="tve:TRV_03462"/>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000006">
        <property type="entry name" value="Electron transfer flavoprotein alpha-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44426" checksum="214C74FBFB7941BF" modified="2010-05-18" version="1">MAVSVVKTGPKYQLDADQVLRASTALLSHIKAEDQRKAADSTVKKLPLGDDSDSEDYGSTGEHSPIWLILTTKKHLVDKNRMKPGKIAVPHSLNPSSTLNVCLITADPQRAFKDTIADPAFPPELAAKITKVIGFSKLRDRYKSFESRRQLLAEHDLFLADDRIILRLVNTLGKIFFKSSKRPIPVRLEEIQKVDGKRVKAADKKRPPTDEKIASVAAPAVVAREIERAIACVPVNLSPAATAALRVGWSNWPAQKLVENVSAVVEAMVDKYVARGWKNLKAVHVKGANTAAMPVWLADELWLEEGDVKEDEVKKVEDSSKKRKSIEGADAGKKSKKSKLLTSTVVERDEEEEEELKARKAKLKAQKAKAVAKVNGDALLLPQEASSSSSKKPRTKLAKMKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S7</accession>
    <name>D4D8S7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022304.1">
        <property type="nucleotide sequence ID" value="XM_003022258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S7"/>
    <dbReference type="GeneID" id="9576907"/>
    <dbReference type="KEGG" id="tve:TRV_03515"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="11">
        <location>
            <begin position="95"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="261" mass="29575" checksum="29C7D952F759E2F0" modified="2010-05-18" version="1">MRWLFWTSDNDKDECNCNSKPSSNSNEKPSTLSRATKDWNALSNATNWSHFIEPSNLIPTILLTSGILFAVRIHRRYLRRIPEAPNISPSYLRQRSILGKVTSVGDGDNFRIYHTPGGMLAGWGWLRKVPTSKKDLKNNTVRNLSINIVISLVEISNLLTDSHPPDQYSRVVATVYAYRFLFFPQDIGLQMLREGLATVYEAKSGAEFGGPEQEKKYRNAEALAKKKGKGLWKTKGSNNWESPRDFKSRMNTMDQEKGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D993</accession>
    <name>D4D993_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000188">
        <property type="protein sequence ID" value="EFE41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022203.1">
        <property type="nucleotide sequence ID" value="XM_003022157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D993"/>
    <dbReference type="GeneID" id="9579088"/>
    <dbReference type="KEGG" id="tve:TRV_03684"/>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="201"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="724" mass="79618" checksum="499CA216ABF4DF0E" modified="2010-05-18" version="1">MAALRSGGAGSSPNGMSSTPPAGANVAPRQAALANRLNSALAASYADSEFRDALETLDSRGIQNTAETRRTLRLDVQKEVIDSNGKIIQDFGRVAEQLSRIGDVIANLNTICQDMRDRLSVAHKETGPVLEEASTLTTKKEEAETKQALLNAFNRHFILPEEDVQVLTSLSEPVDDRFFSILGRTKQIHKDCEVLLGSENQKLGLEIMEQSSKNLNSAFLKLYKWIQKEFKSLNLEDPQIGGTIRKGIRVLAERPSLFHSCLDFFAEAREYILSDAFHHALTIALSGEGADANTKPIEFSAHDPLRYVSDMLAWVHSATVSEREALEALFVSDADDLAKGMEAGIKSEPWSRGEEGEPVFDGQKALRELITRDLSGVARSLQQRVELVVQGHDDIVTIYKVANLLAFYETTFSKLVGADSALVDTLSSLERFAMEHFESLVRDRVKTASNDSAGLLPPDDLSPPEYFTECIESLEQLMKAYDSSFSHAVLNKSFGEGEEGNEFTPILRSTLDPMLDLTRKSTNLLKDSFSRTIFETNCILAARTAVSAYEFASSTHLGSLSNTLANLRAELHKFQHDFLLEKSGLDTLLRALEGYNARSESDNSSSKNKLETVAKLPEFQPAALSAVSQQLDDFLPAALVDATDNLKRVNSAGLVKGVTEEAVEAFASDFEFIEGMIVGADEAKASVGDTDKDAGEERDEEEEQEWSLRALFPRTTGEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9I7</accession>
    <name>D4D9I7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator Medusa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022093.1">
        <property type="nucleotide sequence ID" value="XM_003022047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9I7"/>
    <dbReference type="GeneID" id="9578988"/>
    <dbReference type="KEGG" id="tve:TRV_03780"/>
    <dbReference type="HOGENOM" id="CLU_013895_0_1_1"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="384"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="661" mass="71972" checksum="D9800824586B45EA" modified="2010-05-18" version="1" fragment="single">FELQSPLIFDESLDFSDPEESRFVGAYSDNLLAKPGNLLSMSALDKSQKIEFLDSDETSSALRETSALLACPPGSYGTSMYNPMLDGSFISDDDSANYVQNSVYSGSPFDIRRSPSLESNCNPVPEVTSFSPSTGFEGTKLSIYVESFYDLLNPPTWSFSVLFGSCQCDCTISPLLVEESRFQYVLTVTAPTFVSTTCAGLSVPLQVVINDQEASTQHFARIGSFTYDQEARQMSPRKRRMSSASDGSTAASTHSASAKQIRINDGVKVERLSTSPYSPYLPTPSSMSGYSGQYQQVLPQGQYEHQIQMRATAPSPLASSWSPCISNATAVSCSPPISVTPIGQEMEVNPGNPTLVRTSTIQQALIGAPNPNAPFNPYAMYPSKAVLKLNGDLDAMALDWKPEECEAQRRLVQFTRRQEGSTIHADFKPVSPSERAPNSICISCIQWAGKKECYVTSVDTIYLLESLVGVRFTVEEKNRIRRNLEGFRPMTVSKAKPDSEDFFKVIMGFPNPKPRNIEKDVKVFPWKILTHALKKIIGKYSASYSSTAAALPAPLRSNYSGSPNMPSASHVDVRSGSPAGHQQSAGVTNTLPSHTAQLTPSSYLSVMGTNAGSHPSLTAAYNYSGLPSRHIQPSPVIVPSQASFDFSAYIGHNQMPAYQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9L3</accession>
    <name>D4D9L3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022065.1">
        <property type="nucleotide sequence ID" value="XM_003022019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9L3"/>
    <dbReference type="GeneID" id="9578949"/>
    <dbReference type="KEGG" id="tve:TRV_03806"/>
    <dbReference type="HOGENOM" id="CLU_095741_3_0_1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="181" mass="20109" checksum="20913A3DFF3D39E2" modified="2010-05-18" version="1">MFRLSPAKPSSSGTNPKAPPTSAEYDNGLRVEAKNVYMVLSSTALPRKYDWGILIASNELGGVIFHQTLNGTVWRYIVEFEDITRSTALLVVLKLGEVPDITAEWMDAIKQCIQATEVPGDEFTCRTWALAAIYELANCGFIGMEPSWDIMKKIEEEANDIATDALFSNQKLVMDSHQCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9P3</accession>
    <name>D4D9P3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03836</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022019.1">
        <property type="nucleotide sequence ID" value="XM_003021973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9P3"/>
    <dbReference type="GeneID" id="9578903"/>
    <dbReference type="KEGG" id="tve:TRV_03836"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="240"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="461" mass="51776" checksum="A89705CB10F7083F" modified="2010-05-18" version="1">MSTLEDLDDLEREDKNQKDDRKEGDKKGADKDGDAEMKEAEKKEEEDLIDEEILRSSTRDIINRRKLIENDMRIMKSEFQRLTHEQNTMKEKIKENFDKIENNRQLPYLVGNVVELLDLDVEEEAAEEGANIDLDATRVGKSAVIKTSTRQTILLPLIGLVDHEQLKPGDLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTEQYSDVGGLNKQIEELLEAIVWPMKEADRFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTEATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRVKVLAATNRIDVLDPALLRSGRLDRKIEFPLPNEEARAQILRIHSRKMTVDDKVNWPELARSTDEFGGAQLKAVCVEAGMIALRKGVNKVSHEHYVDAISEVMAKKKDTNVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9P5</accession>
    <name>D4D9P5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022021.1">
        <property type="nucleotide sequence ID" value="XM_003021975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9P5"/>
    <dbReference type="GeneID" id="9578905"/>
    <dbReference type="KEGG" id="tve:TRV_03838"/>
    <dbReference type="HOGENOM" id="CLU_040078_3_0_1"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="34810" checksum="DFEB9F6A6A31CCDC" modified="2010-05-18" version="1">MSGPGAGHQFPSEDVSWMKRDILLFANSIGCTADELHFLYTADWLLQELHPNFAAFPTYPVILPFKHTSQEVIDFYSSKASRAIPGVPPLDPKRTVDGQRRMIFYKPLPVTSEGRKFELQSRVIGVYDKGKVGTVVEVEYLIVDKETGELYTRMIGSAFYIGQGNWGGPKGPASVNFSPPQGKNPDAVHEYQTTENTAMLYRLNGDYNPLHADPAPGKKMGFGGVIIHGLFSWNMVAHAVLAKLGGSDPKNMKEFQARFASPVRPGDKLTTEMWRTGKIEDGFEEIIFTTKNGQGKVVLSNGRALVRVVGTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9W1</accession>
    <name>D4D9W1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021956.1">
        <property type="nucleotide sequence ID" value="XM_003021910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9W1"/>
    <dbReference type="GeneID" id="9578854"/>
    <dbReference type="KEGG" id="tve:TRV_03904"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="430" mass="49910" checksum="1E87CD1D62652C58" modified="2010-05-18" version="1">MLRTSLKSHLCPIKVLRRRPWPPPTAIPSKLSLTQPLEEENSPYYDPYCFYPAKLGEVLHGRYQIVNKLGHGSRATVWLARDLYQWRWLKEKFVAVKINSNNDTRKIPGDSEVDILYHISAANPKHTGWNFIRQILDTFPLENPTSKKSHSCLVFEPLRESLERYCRRWNDGVMPPEIFRIVLQMILQALDYLHSDCHVIHTASDLKPDNIMVKLEDTTLLSQSAREEYTNPLPQKHYEDGRIIYCSRRNYGPLKKITGLVEILDFDLSVRGDGPVTHDGCIQAEIYRAPEVVLDKGYSYSADIWSLGVMLWDFLEGRALFQDVDPLYVEDYDDERHLALITALLGPAPKDLLASGKRTSMFYRADGTLRNPSLIPKDFTFQNTICNMSGERKKRFINFVQRMIKWRPEERSTAKELLSDPWLHEDFPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAK6</accession>
    <name>D4DAK6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIF1</name>
        <name evidence="18" type="ORF">TRV_04153</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000210">
        <property type="protein sequence ID" value="EFE41118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021736.1">
        <property type="nucleotide sequence ID" value="XM_003021690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAK6"/>
    <dbReference type="GeneID" id="9576817"/>
    <dbReference type="KEGG" id="tve:TRV_04153"/>
    <dbReference type="HOGENOM" id="CLU_001613_0_1_1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="271"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="15">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE41118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="780" mass="87918" checksum="4798EE1B9F03371F" modified="2010-05-18" version="1">MFTRAVQEHPERQKKPNALQPNRDRLNSTLQSRNLQSSSQRKADFTSELSRSALDDLHDAVYFGENDSENEEFLEIAYQISKPTQSKSSSHNSSIVDANSRKNDNSTPTEAMPSSSFPIPWSSSPPREQERPNPPHQQPKKRTLPWDDAMQDNKGQFGFSSGYLITNRNTSFKKPMLKSHDVQPTPQPIPFDDQTVKTEQIPVKEKKHMPWDKTFSDVKEEQKELRKQMKSKSLAASEKKLNNVQRPSNTRVPSIFFSEEQNQVIETIVKKGKSVFYTGSAGTGKSVLMREIIRQLRLKYSRDSDAVAVTASTGLAACNIEGVTLHSFAGVGLGKESTQELVKKVKRNLKAKTRWLKTKVLIIDEISMVDGDFFDKLEELARKIRNNGRPFGGIQLVTTGDFFQLPPVPEGGKEAKFAFAAGTWNTSIQHTILLTQVFRQRDPDFANMLNEMRLGRLSPSAIQAFKDLSRPLTCSDNIEATELYVIERAVFYICWKLMVTICRFPTRAEVDRANSERMNRLSGSVMTFHAADSGAIKDEQFRAKLLSNCMAPATIHLKKGAQVMLIKNKDETLVNGSLGTVIAFMDEAGFDNHIREGLKRENGYYDFDDEPSQAKQKIKSMAFDQKANTGSVNTSRQYPLVAFILPDGSERQLLCMPEAWKIELPNGEVQAQRLQIPLILAWALSIHKAQGQTLQRVKVDLGRVFERGQAYVALSRATSKDGLQVSRFDPRKVMVHPKVTEFYQNLSSISDINSGRKPRVVVDGNHSDVEDDFDSIAQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN0</accession>
    <name>D4DAN0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021720.1">
        <property type="nucleotide sequence ID" value="XM_003021674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN0"/>
    <dbReference type="GeneID" id="9576803"/>
    <dbReference type="KEGG" id="tve:TRV_04178"/>
    <dbReference type="HOGENOM" id="CLU_3175711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="47" mass="5231" checksum="BEE134809D18AF72" modified="2010-05-18" version="1">MKKRKKKKQKDDRVRMDHVGGACMHGRDRQVEGYESSPASAVSGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN4</accession>
    <name>D4DAN4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021671.1">
        <property type="nucleotide sequence ID" value="XM_003021625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN4"/>
    <dbReference type="GeneID" id="9576790"/>
    <dbReference type="KEGG" id="tve:TRV_04182"/>
    <dbReference type="HOGENOM" id="CLU_065203_0_0_1"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="300" mass="34039" checksum="4A6FD58852AC1783" modified="2010-05-18" version="1">MASLLRECSAKSSMALCRSYTAPGAQSRLFSSTARMMVGPEAPGYIDVPQSIQPDLPRRPQVKGTLPVPRELFPSRRPDKPTESYIADATPLPSSDTPKVAPGHPQYEQLEWRRKMAGVRRKHLREGLLELHERKKSAHQRMVARSNAKEKRRTQILNQPERDDDRLTASTTVSAMKPMKCKVLPNPGAEERLARSMAKVKDIQEARRHDVVNSIHELYLNAQQFIVNEEQLNAEIDRVFPIDNNPDWANGRRTGENIWNLGPPPTMAVLGNQTKDELTKWETVQRRTKRLAEELTGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAT4</accession>
    <name>D4DAT4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021652.1">
        <property type="nucleotide sequence ID" value="XM_003021606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAT4"/>
    <dbReference type="GeneID" id="9578613"/>
    <dbReference type="KEGG" id="tve:TRV_04232"/>
    <dbReference type="HOGENOM" id="CLU_029797_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58228" checksum="90DFB269076DB605" modified="2010-05-18" version="1">MGFLPFGRQRASPPTVPTDTIIPFHYWDDDHHTRGLSFDIVFRFDDILDHDKLRRALSRLLEIGDWRKLGARIRRNTDGGLEYHVPQSFSNERPGFAFSTTGYGINLTEHPQASRLAQPHNLHAAGRPSVFSTAYAATPEFRSFIRTADFPDRLEGWLCSDSPQLGVKIVVFQDATLVTISFLHSLMDMVGFNDILDAWTAVLRGQENRVKPFIGFFQDPLAGLSKTKTNQLQKYVFTDTLLMGFAWFLFALRYILTVELFWHRREEDRVIFLPAKYLHKMRDKAIDELTSNHVGDSSRLPFISEGDVLFAWWTKVVLQAESPSPSCTINMRNTYCCRSVLAELGHIPSATSALVTNAVFAALTFLSVRQVLSKPLSFTASEVRKSLIQQRTPEQLQALDAIQRNTLDNAHHPALFGNPNMYMIMISNWVKAKLFQVDFSSAVRREGMSLDKRSNQLGRPSCIQGTGTRDYATRNTGVVIGKDASGNWWLLYTLRKQTWPAVEEQILSMAEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB11</accession>
    <name>D4DB11_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021568.1">
        <property type="nucleotide sequence ID" value="XM_003021522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB11"/>
    <dbReference type="GeneID" id="9578529"/>
    <dbReference type="KEGG" id="tve:TRV_04310"/>
    <dbReference type="HOGENOM" id="CLU_1332776_0_0_1"/>
    <dbReference type="OrthoDB" id="4182065at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="206" mass="22655" checksum="23304405EE1F795A" modified="2010-05-18" version="1">MPSSVLFPAMRTLLLLKYVFSLIYLNAICCQTVSAISVVSREGLPMTLSDKCAEALISDVACDPNVLDFKPGYYYSPEILQRACTDTCKSALDSYLDRVKSSCGTETIVGPFDLEASALIVPGMRKDLFQKTCLQDNGRYCNNVAATAAVIADPGGMAWFKYFCFIKIGCQSSREVQFLDSIISARFLQEPFHQILVTCASSKAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB52</accession>
    <name>D4DB52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021504.1">
        <property type="nucleotide sequence ID" value="XM_003021458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB52"/>
    <dbReference type="GeneID" id="9578452"/>
    <dbReference type="KEGG" id="tve:TRV_04351"/>
    <dbReference type="HOGENOM" id="CLU_1876952_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055449" evidence="2">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="136" mass="14110" checksum="464B282260B121B3" modified="2010-05-18" version="1">MAGGALYLRRLFSLVTAVSSSASASAAASASSSASASSSSSSAAASPLRFFDVKKEAQRISHVINTQGRQRQPSTSTPTKSQKGRQDEKKQRKGQGKKGTKRTPSLLFPAGIPFRGLCALVGQPIIAAGEPGVPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS0</accession>
    <name>D4DBS0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor TFIIIC complex subunit Tfc6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021324.1">
        <property type="nucleotide sequence ID" value="XM_003021278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS0"/>
    <dbReference type="GeneID" id="9578168"/>
    <dbReference type="KEGG" id="tve:TRV_04568"/>
    <dbReference type="HOGENOM" id="CLU_018776_0_0_1"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="674" mass="74123" checksum="D770AC19C0EA241F" modified="2010-05-18" version="1">MDAMSAAEQQIVAAETNGSTPIPDPDYEDEAVTQYPASEFSDEEYEADEGINKRRKKEGRNLDRQKNMALAQKKDQPNTQTYSRGLLKPSNHSSKTLQLRLTFGSGDQDILPIIHTRDNWSGGLDLTFPSRESLQVCIGWNSRGSKDIFGVDRETNIRESTTGWDWFYSDIGARFRGKQQTLPITEDVANTHLPSKEIPKTTVLIGPSDAQTTFLLGRGESFDFSSAWPSTESIAIKQESEEAPVSQANERASDAPNRVKAREGWIINLGSKIQCLSWAHNCNGNSQFLAIVAPIHDSQKAQFDDGNIRGAPAFTPSPPYPAAIQIWRFEARDPKSGLRKLNMNKPPFLHMVICTEFGTISRLCWCPISVNRDSDDGNDSKTTRPRPALLAGLWSDGTVKVFNVDLSDSKSETKYAIGSANGFIGVWSLVQSARRESITNPEPYLYVPIHDTYILNVASAYPTHPYIIAATSVGGQTRLVSLQDPAAEVVDALRLRIGTQCLVYSPFLRSFITNDEGDFVRLLPLRRFFSSLAALKSRSIATSLATASLHHPCILAGNAGGAVIGNNPLRKLIHSKEKQWQQTWFSQEWINGGNNNITPGPVVKFYDGFKAETASLAKGSSAQDKEIGQVGMMTVYEEQTAITAIAWNPNASCSGWACAGMGSGLLRVEDLAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBW4</accession>
    <name>D4DBW4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conidial pigment biosynthesis oxidase Arb2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021302.1">
        <property type="nucleotide sequence ID" value="XM_003021256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBW4"/>
    <dbReference type="GeneID" id="9578147"/>
    <dbReference type="KEGG" id="tve:TRV_04615"/>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="60"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="354"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="495" mass="56243" checksum="63662DEAC15F648D" modified="2010-05-18" version="1">MFDGLFGAMYIRYLFDHYLAFYGHALTFNRPKPTAPAPWSLISNNPKDIESMKKAVANPHVVVVSDWTRFKSWEYMKAQEDSGYTIFCVDSILINGKGSVYCPGEDFLVNHTMDYMKWAIYPRHVNDKGCLPFVRSTENKYLRDGHPETIPLHLQQGCVPSEGEQAVFEVDPADEWVSFNFVDAATFKTPVFAIDEHEMWVYEADGHFIEPQKVDTVKFYAGERYSVMVKLHKNDARDYTIRVMDTGLTQIIGSYATLRCKRNPNDKNVHEAKESKGILNYGGLNTTHVVTLDRDNLPPYPPSAPAPHADALYLLDTHRVKTAWTYTMKGGAMYQEDRSAYAPLLYYPDSADAMDESLVIRTKNNTWIDLVVQVGSLPNQPQEFPHIMHKHSGKTWQIGAGEGHWNYSSVEEAMKAEPTKFNLKTPNYRDTFITSFDGPSWIVLRYHSNNPGPWLMHCHFEIHLGGGMAIAFMDGVDAWPKVPPEYGPGKGGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBW8</accession>
    <name>D4DBW8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRm160/300 splicing coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000233">
        <property type="protein sequence ID" value="EFE40650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021268.1">
        <property type="nucleotide sequence ID" value="XM_003021222.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578113"/>
    <dbReference type="KEGG" id="tve:TRV_04619"/>
    <dbReference type="HOGENOM" id="CLU_001976_0_0_1"/>
    <dbReference type="OrthoDB" id="5408934at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="644"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1791" mass="194125" checksum="34ABD7EF17B9D669" modified="2010-05-18" version="1">MPTPRTPRRTPNRGSARPAQFKEIKPLDLGEALGPHDSATVREKVRKWQQLGGGAVIAPDVGAGSDEDESSSGAAKVKEPKQTPNKSPAASKRPTTPKDKTTPEPERKTKSPTKTKVTPRTTPRSTPRTTPKKRVVSDAHWRRNRSPPPSSSAPSSAHATPTRRKDVLQRYEEAKEKAARSSGIKDNDGIAVYPGPLRVPETLKSTSSAWSSDVGSSAGEGTPDYSGHEKTSPQKRTPKRTLRPNYCVNDDRPRLGSPRRKIQSPDIPRASSPRKKSLSPNQAESPPEPAPAKPERAEPVRRSEIRPHNLLSGNIISQVIDESKKMFASIKPPEPSPPPQQHQSPPGPSVPHGSKVEAWLSSTANADPFVDDNTSTISAPEPLRSSTTRSSIPHKEHSDSECEHESTKKRPSPSSDSKIRPAKPVRGKYDYSDGSDSDETHRAKSTPRRRESKSDMSVDSVTDSQPSTLNRGKASSKSRRHLSASTEAERMSKLRESVEEALQGSSLDRPISSDGSEVSAVDRPPPLMLKRPFPSTGGHRLSTIASVDTLTSSTNTSTTARETSSHPLTQSELTSQLDDGNDDAVSDSEKRDKFDPSSLPGPTQPLKRRLTKHSDLMSVLSIPGGRSRSIRSARSIRTNRSRLANATVSDIMRELASDEVKYMRELRTLVGGVIPVLLTSILSRADSAIAAGLFRRTADPADQENFTRPIINMGVSLEKLKALHKRLPLNNTDALLSWAVSAQKVYADYLSAWRLGFQDVIVNLAPPDPEDPLKAETQSLCAGMAQDENGDVIDGDGERVDVAFLLKRPLVRLKYLSKTFKGLNYVQPSPKAGEVAETYQKLVTDARRRANEERSRLEDDAAASIDASRARDIHTLAILKDVEVNQTRRVRARDFFDLSLLHSTGQQIDCRAELLLRDNAPGEAPGGDLFICEVDETDRWLLFPPIDCTCISARNGDEQGEIVLMVRASAGNSTEWYELLSFITDDEQIGFEWVQMIGLNPVPPKINRSLSFVNRAKERKEKLAQARQASHNGTIPIRDYDPSEVDVPIGEKATVVGEDIGHKKESTSNKHDTAPPTTPSRGPGETVELTSSVSPLTLKRSKANRRSKYDFASPTSPASSDIQSPNRESSNRPSSPLLSKEDRRGRDRTPSPTYSSGSKQAKRPIASLVQPHGRRSLSPVPSLEFPTIPKLRKSSKDSPPTSPKNVPLPASPVQKPEDKVEQSTPSKGRKSLANGEKPARASSDDQVSSEDAPIPPPHSTPSPVSSKQLKSPVISPPAPPYARHRRTSSPLKHEYAPSTASESSGSDTSSIHRYDVDSSSETSDEELEDDDIPTPLPPITRRLSKRAPPLESVDVTPTNSRPTSAHRSSPKSIHSSSDRASKTIASVFYWHDKGSWEPLHLNECHIIVSPGLIEAFELGSSHSRPSSQGNGSAPESTRPSGRPLVALELTPLVPIRRGTAIDISIRSPPTARSKVSSGSNVMFRSRNPDDCDKLYGLINHSRINNPTYIALQNAVPYPSQPTSISRQNSTRSTKGGWFSWHGGFSKSSYRASTAPPASLAAGTESSVGTMSSAFSALKRFGAGSKMFSIARSTLTSRNGRDDTSLYTSTSTGSGSGRRISSTNPETAKMAAEGGIGLTNAKIRLYIRESAAKWRDLGAARLTILPADPTPSNTPPNHPDDQEPSGTSSPPSGSAGDPAALLAGRTGAPVKDEKRILIKSKISGETLVDACLGESAFERVARTGIAVSIWEEYDGIASEGGVVGGCFKVYMIQMKGEAEAAYTFGLVGKLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC14</accession>
    <name>D4DC14_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021234.1">
        <property type="nucleotide sequence ID" value="XM_003021188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC14"/>
    <dbReference type="GeneID" id="9578079"/>
    <dbReference type="KEGG" id="tve:TRV_04666"/>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="242" mass="26468" checksum="64498A44A256AC0A" modified="2010-05-18" version="1">MSRRHIVLTGAPVPSSLCWEEDELETAGSKTHHAAAEARWRSLEKVRETTVLTGPIDEGEWFFTAGAVQRYSGESVSGLETTALSAFYEQSFALHEGISSGSFDNDDTRSFGDDDSTAGLIDSPEGDASSLLPTGSQLRSTVRPHLSDLEDIPKAVYVNGLAPRVVTVNLIVAVISVEQRRRVRTRWGRAMDLVELLVGDETKSGFRISCWLPPRDDLHQLQQQQQQPKQSPLGVPGGSPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI4</accession>
    <name>D4DCI4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021063.1">
        <property type="nucleotide sequence ID" value="XM_003021017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI4"/>
    <dbReference type="GeneID" id="9576710"/>
    <dbReference type="KEGG" id="tve:TRV_04839"/>
    <dbReference type="HOGENOM" id="CLU_047749_0_0_1"/>
    <dbReference type="OrthoDB" id="10431833at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055762" evidence="1">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="36522" checksum="04F17062849607BB" modified="2010-05-18" version="1">MLFVLSVAGLLAVFLYYVGRCQADERARAIEYQQRLRKVRPVSSDRVRCWPSRSRLRRRRLLLRLRYPVVEPVAVELPATPSPVSSVASSPFILSPVSSAVSSPFILSPVSSAVSSPFLLSPVSSASSSPFLLSPVSSASSSPFLLSPVDSVVSSPFIVSPVESGVSSPFLSSPLSERSVSSPVPPVELSVRLAALRARVLALSSGPAADHTPLPASAPSRRVARIRQGVPLVVRPTRIPTPVPSRVFSALPLVLERDARPFAETLGPVAATPMDIRNILRAQRLVANVAAEARSSNSLPRKSALRTTTSVENTKRVSFHEAVTVVNVEKWVVPGVHSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCK4</accession>
    <name>D4DCK4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sad1/UNC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020994.1">
        <property type="nucleotide sequence ID" value="XM_003020948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCK4"/>
    <dbReference type="GeneID" id="9577846"/>
    <dbReference type="KEGG" id="tve:TRV_04859"/>
    <dbReference type="HOGENOM" id="CLU_006633_0_1_1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="215"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="874" mass="96583" checksum="3799A57A46554510" modified="2010-05-18" version="1">MAVDKSNTICQARVSDLGAEYIRYPICLETRWNAAASASASAAASATTGSEGPSTTRSASGIYADSKDTSGSVTVPVPGTASSDSSSSKETGSSGNGDDADVESPLDNSNFLSFEEWKNQNFAKAGQSAETMRRHRQDKGQQARRRHTRSPQMNDPLDGLGEESEIDLEFGGFSTDESGVASWERKDGGRASPDNIDSVTAPGGAIVGGKEDKHPSQPIFELDGQDAENMPRKGIGRRKHAGTTCKERFNYASFDCAATVLKTNPQCTGSSAVLNENKDSYMLNECRAKDKFLIMELCDDILVDTVVLANYEFFSSIFRSFRVSVSDRYPIKADKWRVLGTYEAANARQVQAFAVENPLIWARYLKIDFLSHYGNEFYCPVSLVRVHGTTMMEEYKNDGEAARADEEEDANAQEEAEQQRQQDEQQQQLEQKEADVVVHPDVSVPEVVINDQMVPLSNLSDRELDELRCFVERNETESILLGLVSSKMCAIQERAAHIASQPVTATRVKDEAAAPASGSITSTNTPEQIRSVSSTRTPTTSDREETRRSSTGSSIAANGSHTEPTRMNSATYSPSPASPPPNPSTQESFFKSVNKRLQMLESNSTLSLLYIEEQSRILRDAFNKVEKRQLAKTSTFLENLNSTVLQELKEFRQQYDHLWHSVFIEFEQQRQQYHREVYSVATQLGVLADELVFQKRVAVIQSIFVLVCFGLVLFSRSSGTPYLEFPRNIVTRTRSFRSSSVTYGSPAPSASPSPPPMSRMGSSILSRSEADDDNLHHNHSRHHRSPSEQTDYEVGNPTFTYSPPTPTSRTTTPERTRKLRFSSEPQSGLAASETGSPATMSDPELSLRKRPIKSVEVKHESESDAEQAEGDSFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD24</accession>
    <name>SCPA_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Carboxypeptidase S1 homolog A</fullName>
            <ecNumber>3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Serine carboxypeptidase A</fullName>
            <shortName>SCPA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SCPA</name>
        <name type="ORF">TRV_05031</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular serine carboxypeptidase that contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6"/>
    <dbReference type="EMBL" id="ACYE01000255">
        <property type="protein sequence ID" value="EFE40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020871.1">
        <property type="nucleotide sequence ID" value="XM_003020825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD24"/>
    <dbReference type="SMR" id="D4DD24"/>
    <dbReference type="ESTHER" id="triru-SPCA">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GlyCosmos" id="D4DD24">
        <property type="glycosylation" value="14 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9577701"/>
    <dbReference type="KEGG" id="tve:TRV_05031"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397825" description="Carboxypeptidase S1 homolog A">
        <location>
            <begin position="20"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397826" description="Removed in mature form" evidence="2">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="652" mass="71675" checksum="09B03AAF0D8540FD" modified="2010-05-18" version="1" precursor="true">MRLAASIAVALPVIGAASAQGFPPPVTGVTVVKSKYDENVKITYKENDICETTEGVRSFTGHVHLPPDNDYFGVYQNYSINTFFWFFEAREDPKNAPLSIWLNGGPGSSSMIGLFQENGPCWINDDSKSTTNNSFSWNNRVNMLYIDQPNQVGFSYDELTNITYSTINDTISVADFSSGVPAQNLSTLVGTGSSQKPWATANNTVNAARSIWHFAQVWFQEFPEHKPNNNKISIWTESYGGRYGPSFASYFQEQNEKIKNHTITKEGEMHILNLDTLGVINGCIDLMFQAESYAEFPYNNTYGITAYTKEKRDAIIRDIHRPDGCFDKLAKCREAAKEGDPHFYSNNATVNAICAEANSDCDKYLMEPFQEANLGYYDIAHPLQDPFPPPFFKGFLSQSSVLSDMGSPVNFSHYSQAVGKSFHGVGDYARPDVRGFTGDIAYLLESGVKVALVYGDRDYICNWLGGEQVSLGLNYTGTEAFRKAGYADVKVNSSYVGGLVRQHGNFSFTRVFEAGHEVPGYQPETSLKIFERIMFNKDIATGELDIAQKQDYGTTGTESTFQVKNEIPPSPEPTCYLLSADGTCTPEQLNAIENGTAVVENYIIKSPAASKGNPPPTTTSSPTASPTAGSAMLKAPVAMLAISALTVLAFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD71</accession>
    <name>D4DD71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020852.1">
        <property type="nucleotide sequence ID" value="XM_003020806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD71"/>
    <dbReference type="GeneID" id="9577603"/>
    <dbReference type="KEGG" id="tve:TRV_05078"/>
    <dbReference type="HOGENOM" id="CLU_619589_0_0_1"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="435" mass="46444" checksum="46445CB1596DD238" modified="2010-05-18" version="1">MITIPMASEKPINLTSVEPEATSPGRSSSPALSSSSSSYSSTALSPASFSSSHSSATAYSPVISPSEDYHQPPTNMLKVATQPAVYPTVPSIAPPLTPIRNQVGPNINKRPKLSLQTSCVPVTFGKSSTALSLAVSSNSCQSPTNRNTFKNAYESFHRINSPICRSPLKGPSRNRQRAPSSPARAGPVRAAEPPYKLPKGIRGILRNSPIPSPAQAEEQLGSPEATASTPSTKRVKYRYPLDEIIKTVKFTAKHSDIESTDASGASSPLDTYTYSSSEEDSDSSDSASSGSTPSEDESENAVKSPKRTRKQTRSKHKSFRSQRQILAAGVRDGILPSREDSLPPQTPIHQRTVQREWRWTLGPIKDGHVQSSSPPSSDLATPPAEASYEVPSTPHTEKKNDDTPLAFADMTPPPSQGSGICSSPVVKPGSLRLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDH2</accession>
    <name>D4DDH2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein SUAPRGA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020732.1">
        <property type="nucleotide sequence ID" value="XM_003020686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDH2"/>
    <dbReference type="GeneID" id="9577431"/>
    <dbReference type="KEGG" id="tve:TRV_05183"/>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000007">
        <property type="entry name" value="Regulatory protein SUAPRGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="291" mass="32903" checksum="F7EA2640A3D2B62E" modified="2010-05-18" version="1">MFSIRSLTRSVPRTLSRSIATSAARPLQRSAFFQPTWKLMSRPSYAAFSTSRPRFEAAGQVDVELAAKFQEELALETESGETEELPESVKYFLDNGPFEIIDKAGEEEVVLTRKFGDENIRVSFTIADLQNINPEEDFADSALQDELEMDQSRSNKDASPEENIDEQPLEPGYLARVDVTIEKPGKGAMHVDAVARDGLIQIENVSYFSKAELATAETPDKEWERQSLYAGPPFGNLDEELQTLIERYLDERGIDTALASFVPDYIDFKEQREYVRWLGSMFLLPLTIIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDS9</accession>
    <name>D4DDS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020614.1">
        <property type="nucleotide sequence ID" value="XM_003020568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDS9"/>
    <dbReference type="GeneID" id="9577313"/>
    <dbReference type="KEGG" id="tve:TRV_05291"/>
    <dbReference type="HOGENOM" id="CLU_031393_0_0_1"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="35827" checksum="BE5E0CC5DCF41A65" modified="2010-05-18" version="1">MAAGFGFSVGDFIACTKVAKSVYLAFREGTGASSTYQRFVADLNGLLCGLEEIRCLEFDESQKYQKLALQEAADQCQQTIETFLLQHAKFKASLGKEHTASKFKTRFHKVDQATLEQSALLMKETQNRIGQTHNMLGTQADTLSRILNILEVSNTQPNIRDVRSVMMEAFDMNMKVYRMALDLQKSQSQPHVDYQAPALPPQIERQRPVELEDAHGRVTPFHVEFINSFEALQAVLEARFRHVPGWKKVKNMEYVMKESNSKRQLDFKAPWESVFLPGRSVTMSMVFWMPPPSGLRCPGCQLESKESATGYEIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDT2</accession>
    <name>D4DDT2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020617.1">
        <property type="nucleotide sequence ID" value="XM_003020571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDT2"/>
    <dbReference type="GeneID" id="9577316"/>
    <dbReference type="KEGG" id="tve:TRV_05294"/>
    <dbReference type="HOGENOM" id="CLU_085820_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="229" mass="23566" checksum="6EE0922A916731EF" modified="2010-05-18" version="1">MTTNRPFLANFLAAFRAQTAYKTAPSKPPSPGPSSSHIGSSYSPPSSSSNTTGTRTIASKATANPAPSNPQQPNTNSIATAAAASSTSNHFSSHHHSHHHHHTHAHAHTHSHTSSPSSRAPISSTSHTSSSAAAQTPAVSNSTTSPIPVPTPSSSTSAVPFSSYDRNRRGSDSSSGSGGFRDALGPEKWYIGGRTTSGEERLYQLGMVTKGGGRLGGGMRVGSVDQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDW9</accession>
    <name>D4DDW9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000277">
        <property type="protein sequence ID" value="EFE39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020564.1">
        <property type="nucleotide sequence ID" value="XM_003020518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDW9"/>
    <dbReference type="GeneID" id="9577268"/>
    <dbReference type="KEGG" id="tve:TRV_05333"/>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="392" mass="41863" checksum="F645429346269340" modified="2010-05-18" version="1">MAGPKDAAIPSWQQAASDNSSTATSSAAATESRDTLLEQARRFLQDESISEASTDKKIAFLESKGLSNDEIHTLLGISRNTEATASASDNAGSNSSTEESESQSKKERAGESSSQPTQSPAAALPAPTPTASPSKDVPPIITYPEFLLRQSKPPLITFQNFLYTLYATAGITASIYGASEYLAKPMLESLNCARHEFSETVQENLKGLNEKLEGSVSKVPASSTARPKGISMDKESEDDNESVTSDPTELFHRDIATQTTDLEPTAPSQTAVGTEIQTVSPQTVIEEHHSRLQSLSSSLASVVTTEKYSDSTQGYAKDRLSELQTYLDSLTYSAPLYLTSSLYGSYDDSADAKKAANGEDEAIAAFKAEIRSVKGTLLSARNFPSGSGGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEJ4</accession>
    <name>D4DEJ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000298">
        <property type="protein sequence ID" value="EFE39718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020336.1">
        <property type="nucleotide sequence ID" value="XM_003020290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEJ4"/>
    <dbReference type="GeneID" id="9584086"/>
    <dbReference type="KEGG" id="tve:TRV_05561"/>
    <dbReference type="HOGENOM" id="CLU_2499501_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="86" mass="10159" checksum="05C0AA1A09F00736" modified="2010-05-18" version="1">MSVDVAAGRDGDVVVVMLEVVDVMMQARHRWSDDVEARQRIEERREKREEEEEETWEEDRKKKRRRSEDVISESESEPEAKAKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEQ7</accession>
    <name>D4DEQ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000305">
        <property type="protein sequence ID" value="EFE39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020292.1">
        <property type="nucleotide sequence ID" value="XM_003020246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEQ7"/>
    <dbReference type="GeneID" id="9584031"/>
    <dbReference type="KEGG" id="tve:TRV_05646"/>
    <dbReference type="HOGENOM" id="CLU_127259_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055477" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20068" checksum="1EC1C59B408D58B3" modified="2010-05-18" version="1">MTQVQLSFFFLFFLLSRRPLPGSASNASLVVAVFLCWRKGKKGRKKKKRSIHAAALRASPSRCALSSALLNITFTCQKVERRKETNKTKKDEEREKDGGERSSQLSQHDERASEDSLGVPGHTTRAAFPAALLAVSPPDQDPPAPFYRTRRRRRCSGAAGRSRTVCAICQGPETVCYAAGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF30</accession>
    <name>D4DF30_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000328">
        <property type="protein sequence ID" value="EFE39539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020157.1">
        <property type="nucleotide sequence ID" value="XM_003020111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF30"/>
    <dbReference type="GeneID" id="9583931"/>
    <dbReference type="KEGG" id="tve:TRV_05775"/>
    <dbReference type="HOGENOM" id="CLU_2518852_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="85" mass="9641" checksum="1AA6C002DA88F1C6" modified="2010-05-18" version="1" fragment="single">PGHGLFLRVLASKEASQDTDSLLLRFTILLHWIQLPSTANFTCQQHTFSPAFLPLTTYTSNSSSCSLLISSYKKKKRKKKIEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG49</accession>
    <name>D4DG49_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000346">
        <property type="protein sequence ID" value="EFE39182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019806.1">
        <property type="nucleotide sequence ID" value="XM_003019760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG49"/>
    <dbReference type="GeneID" id="9584557"/>
    <dbReference type="KEGG" id="tve:TRV_06151"/>
    <dbReference type="HOGENOM" id="CLU_2225115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="106" mass="11241" checksum="59B1C0AEE3363C66" modified="2010-05-18" version="1">MEGTILRGRKSGRHQRATGKDEEGREGLRAKQAGWPEQQPEKQPEMTADRRENMTQVDSPGDGGGGGAAANDDDDDDADDVTNRTGKDGGEDVGFWAGLQGEGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGB3</accession>
    <name>D4DGB3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000350">
        <property type="protein sequence ID" value="EFE39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019734.1">
        <property type="nucleotide sequence ID" value="XM_003019688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGB3"/>
    <dbReference type="GeneID" id="9583655"/>
    <dbReference type="KEGG" id="tve:TRV_06217"/>
    <dbReference type="HOGENOM" id="CLU_1876954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15588" checksum="9A7200AB7A08C877" modified="2010-05-18" version="1">MPLDDNYILFFPPFFFLPSLCFSLFSLISFQNPAAALHEFIFTTVLCSLSLFYLDKTKSEKQREERNGRKREGVGGSRRDEGMVSWSPGMLNAVSFAPFSAVLCLVGRWFWYLLTRLEGPLQAGELDREMQRANDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP2</accession>
    <name>D4DGP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019629.1">
        <property type="nucleotide sequence ID" value="XM_003019583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP2"/>
    <dbReference type="GeneID" id="9580159"/>
    <dbReference type="KEGG" id="tve:TRV_06347"/>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="446" mass="50755" checksum="7716C4F21C1CCFD0" modified="2010-05-18" version="1">MSSIETVHLPLPRLPEGWAAADKDFKAVGCLSAATRRNVEPVGPHFLAHARRKRHRRTFSEDERILAQENVKKIEEDDADEISEPEDPMMLQRDAKDWKGQDHYAVLGLSKYRWRATPEQIKKAHRKKVLKHHPDKKAAAGAGDENDSFFKCIQKATEILLDPVRRRQFDSVDSAADVEPPNPKKKGDFFKLWHPFFKAEARFSKIQPVPMIGDDNSTKQEVETFYNFWYNFDSWRSFEYEDEDVPDDNENRDHKRHIERKNANARKKKKTEDTARLRRAVDDALAADARIKKFRKEERAGKDKRRLEKEAEAKRLAEEKEKAKLEAERLEKEREEAAKAERAEGKKAKEAAKNAAKKNKRVLKGSVKEVNYFAEGDPSAAQIDSVLSDVELIMSKINNDELATIASKLTAAGKDGAAVKGIFSAEVTRLVGSGALKEGDIKTLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGT7</accession>
    <name>D4DGT7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019596.1">
        <property type="nucleotide sequence ID" value="XM_003019550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGT7"/>
    <dbReference type="GeneID" id="9578370"/>
    <dbReference type="KEGG" id="tve:TRV_06392"/>
    <dbReference type="HOGENOM" id="CLU_013984_0_1_1"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026797">
        <property type="entry name" value="HAUS_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="624" mass="70680" checksum="CB54E5C0E8FC3854" modified="2010-05-18" version="1">MRVSTVSSGAETWPQAPPIAVFIRNLKLLRLDLRPDWPGIVPSTLSDNQNNLRRRVQAVEWTLFYLFQLWDPELTRNKLQPFFPPLEPLQSSNLRAALFRSLSELTKNGTLGRERILRKAMLEECTGEKFDEILAEFSTIVLRKVVASSREYRTGAPPLSLPIGKRGPPSDTQNLLPMIIAYRASLHSMIDQKNELNSTCRDLKQFLHLKSNELANSRRMPKPLASELRYQQQIQDSINRSWHGDINWANTILNGDPQAVSEPLLEMDFSQVWSGMKKVEVKNDIESPNHPDLLAELEDRLSKQKSRLQKWRKFKDSLELDSLRTRLQRSEDYKEPEVVPQEQDGTIDPLAEHDETQKTPTRSANIDINSMVPLEQEIYYTPDASPNPKTINDTKPVQRETSVSHEASEATNLIKADTSGNLSTEDLLAMQLGALSLEKDNHPELPETNPKIDDHPIIGDKRGIQDDGAQPQHDEDPVSRAATLLERTRQSMLFVSAATPRPWKPISENRRQSQLLLPGDPFETPEKRAENKEKPNAEATDEDRYSDYVDYDSVFKSRPKVAASPIPFESAQSKTSGEENQEEGCSLSELGLDSSPLGKVKTRPRAQTAIRHPIPPEDNAETTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGY7</accession>
    <name>D4DGY7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019568.1">
        <property type="nucleotide sequence ID" value="XM_003019522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGY7"/>
    <dbReference type="GeneID" id="9578342"/>
    <dbReference type="KEGG" id="tve:TRV_06442"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="28387" checksum="6ACF37DA5DED6686" modified="2010-05-18" version="1">MDVTNHPAAMCHRLPSSISDVQGALLEPLAVCLHAINRSNPPTAADVALAKSVAAANGGAAPDSETAVLIFGAGAIGLLLASALAITQHFTTIVLADINQARLDIASSLPFGCIKTCVLDPPGSTATSAQEEDQAAKDLAATLLRRFGFGHGFSRVFECTGAPACVRAGIYASSAGGVVVQIGMGGPSLPSIPMSASALREVDLIGVFRYNGRCYPAAIQLASSPVFGQVADKVATHTVELGEDDGQKAFRLAASDRDDDGKTVVKVVVIGGGGSSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH40</accession>
    <name>D4DH40_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000370">
        <property type="protein sequence ID" value="EFE38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019480.1">
        <property type="nucleotide sequence ID" value="XM_003019434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH40"/>
    <dbReference type="GeneID" id="9577930"/>
    <dbReference type="KEGG" id="tve:TRV_06495"/>
    <dbReference type="HOGENOM" id="CLU_756916_0_0_1"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="41207" checksum="3A2A6D58D5677BDF" modified="2010-05-18" version="1">MYAGAGRTRSAGTLGAREKVFFFFIFIFIFFSSSEFPFYIPIQPSIHIHILVSPLSAILVPVHDHVHVLKTQYRQHQQQQQPPTYTDRPAHVFNGSTYPAYPPASSATTTTTADKRAAEDDTPNHSSHHQQQFKDLPEGKRRKFILVEDPQRSCRVRVKVMLDQVDMKEIPDSYRKANSVFPRTYVPVHSPFAHHRRKGDRFMNDDDESQPAGRLVAGSSSADADEDVTAGKTSVPMAMLEGEEVLVPRLTRAKKEREELLNDMGYRMSWGQSRVFAGRMLFLQRSMDAYRNKMRNSMLTAGHETSEIAPYFETRVGKRRWLDRGRKADAKDKDSTAATTAVSAVSAASPPAVLTTASSRSAEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH54</accession>
    <name>D4DH54_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000372">
        <property type="protein sequence ID" value="EFE38820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019465.1">
        <property type="nucleotide sequence ID" value="XM_003019419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH54"/>
    <dbReference type="GeneID" id="9577915"/>
    <dbReference type="KEGG" id="tve:TRV_06509"/>
    <dbReference type="HOGENOM" id="CLU_042952_1_0_1"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="47870" checksum="0E3736CCD1D0B2C3" modified="2010-05-18" version="1">MLSIRGQGQENLVNAHQTAAASKPLNQGMRHLLPKTPGKLPPKTPFRLPLHDENRPLTFGKGLGAGIGKSVVLKGQDENAALQGKGKGAEKKALATPAGTIKQRSAKRGSTRKVKKAAPLPEQAAQEKTVTVEEEEEPEREIEYMPPKPKRESIWSALPDDDGYITYDTTFPHFKGNNFARGWEKLYEDTSVGEDGLTAKQREEKELDDAYNKHIEELIQAQIDSIGTLELEGEGDDAKAEAEESRPVSRATTKSQRSERTVSTLRSKSAAQALALDPKESVRTRSSARLAAKAAAKAATATTTTTTKQKKTTEPTNPSSMRHTAAVASSRSTLGYSKGREALAALREVTDQPKSSSKTNRSTNNAGGQENETDHLSPELYMQLYGPPAFGTEMWSRCKIAGYFDDEVKTTEELLGIDSTNVDDAFVEDEESANFQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH67</accession>
    <name>D4DH67_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019442.1">
        <property type="nucleotide sequence ID" value="XM_003019396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH67"/>
    <dbReference type="GeneID" id="9577892"/>
    <dbReference type="KEGG" id="tve:TRV_06522"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="148"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="647" mass="70989" checksum="2C07B715988D1CDC" modified="2010-05-18" version="1">MKQGRSKEEADVHLTSTVDFLFSFFSLLLFFSSPCDRSCTSSSSSSSSSLLPRPLSLPFFVPFSCVSGISRDTTLPRPSPPLPSRRNPIHRERKTMDEKTDMAPAYDNGPHKAVDVKNAAYGEAADLYGDAEAAERYGYVARGLKSRHIQFIALGGTIGTGLFLGIGRALTQGGPLSLLIGYTFVGLAIFAMMMSLGEMATWLPLPGAIPQFCARYVDASVGFAVGWNVSLSPASLITLNAAAVIIQYWPGAQDVNVAAWIGLVIAIIVFLNVWAVSVYGEAEFIFASIKIITIVGLLLLALIIDLGGSPTGDRIGFRYWKNPGAMNQYFGTGDKGRFLGFFSTLVNAAFSFGGVEAVACAAGEAENPRKNIPKAVKRVFWRILFFYVLGALFLGMLVPYNDKNLLTAQKNNEPGAAASPWVIAIRRASIPVLPSIINAVILTSATSSGNAFLYTGSRYLYGLAQNRQAPRFLLHCTKQGVPIYAVGVTASISLLTFMAATTGSAQVFIWFQNLTTVASLFNWVSVLVAYIRFHAALKAQGVERNTLLLKSPFQPYLAWVALIFFSIIIFFNGFDTFKPFRFQSFFTAYIGIALYFALLIFWKVFKRTRWIPSAEADIFTGKAAMDAVEWPEQIPRNIFEKIWFWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHF5</accession>
    <name>D4DHF5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019330.1">
        <property type="nucleotide sequence ID" value="XM_003019284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHF5"/>
    <dbReference type="GeneID" id="9577652"/>
    <dbReference type="KEGG" id="tve:TRV_06611"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25657" checksum="511F844BFC9DBE80" modified="2010-05-18" version="1">MKLLIFGATGAAGGLTVRKAIDHGHEITLHVRDRSRVPEAISSSDRVKAIYEGSLSDESSLSAAIKGQDAILSCIGPKSIFGDYGRQFSDGYRLILELMRQHGVTRIIAMSTISAYDARDQFGFMRTAAYWTVYMLGRRSQREILGIGEVFKEKGEGLDWTLYRVGVLGDSQEDGRVAQTGWIGDGKTTIYLERRDWANWMIQEVEREQPQWVREMPVIYSPYPGGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHK7</accession>
    <name>D4DHK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLL-like beta propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019319.1">
        <property type="nucleotide sequence ID" value="XM_003019273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHK7"/>
    <dbReference type="GeneID" id="9577641"/>
    <dbReference type="KEGG" id="tve:TRV_06663"/>
    <dbReference type="HOGENOM" id="CLU_059884_2_0_1"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007132">
        <property type="entry name" value="DUF346"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03984">
        <property type="entry name" value="DUF346"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLL-like beta propeller" evidence="1">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="38726" checksum="90D7D06F1A7E0E54" modified="2010-05-18" version="1">MRLGKAAENALPLLNQIAASAISWSSGRIDVFGLGTNNGLYHKWWNGAWGPSTTGWEYLGGVFSAEPTSVSWGENRTDIFGLGTDNQMYHKYWDGQAWGPSQTGYEALGGVFSSEPTAISWGENRLDIFGLGTDNACYHKSWNGRAWGPSQTGWENLGGVFVSKPAAVSWGANRIDLFGIGTDNQMYHKWWDGSRWGPSASGWEALGGVFNSYPVVVSWSENRLDIFGIGTNNGLFHKWWDGQAWGPSQLGWEDLGGVLSSPPSAVAWGANRLDIFGTGTDNQMYHKWWDGSRWGGWEALGGVFSSGPSTCSWASGRLDIFGLGTNNAMYHKSWSGRWGPSQTGWENLGGVFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI23</accession>
    <name>D4DI23_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019146.1">
        <property type="nucleotide sequence ID" value="XM_003019100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI23"/>
    <dbReference type="GeneID" id="9580094"/>
    <dbReference type="KEGG" id="tve:TRV_06830"/>
    <dbReference type="HOGENOM" id="CLU_032409_2_1_1"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="36308" checksum="AB2504CB990D76E0" modified="2010-05-18" version="1">MFLSRFRSDDEEEAEDLLASFLPILFPDSTTTCVGQPGQQLVYSSPAFGELALTIPVHPRDQAKGKAEAAEAAEAPRGEGVDRACMLFAHFLWGSSLLVTDGIERASSSSSSTSSTSINSPFEAAADGSVWSVKGHDILELGAGAALSSIVSVLAGAESVTVTDHPLAPGLYGSIQANIDRNIPKHLAHRISVQPYQWGVLGQGGSVDEEELETAYLDQMAGFAAANRARFSRIICADCLWMPSQHENLIQTLLWFLAPSSGSPAGIAWVVAGLHTGRHIVASFFQKAVSAGLKIEKIWERDMNSTEGETTREWKPVREDEGPENRARWCIVGLLSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIW7</accession>
    <name>ECM14_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ECM14</name>
        <name type="ORF">TRV_07128</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks the conserved Glu residue in position 512 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018860.1">
        <property type="nucleotide sequence ID" value="XM_003018814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIW7"/>
    <dbReference type="SMR" id="D4DIW7"/>
    <dbReference type="GlyCosmos" id="D4DIW7">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9581504"/>
    <dbReference type="KEGG" id="tve:TRV_07128"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000453253" evidence="3">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411192" description="Inactive metallocarboxypeptidase ECM14">
        <location>
            <begin position="185"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="220"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="418"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P15085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P38836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="596" mass="66596" checksum="209CE2DBF708C4F5" modified="2010-05-18" version="1" precursor="true">MHFSVRLSLFLTLASSLPLVSAVPQHEDQAYTFSSSGRSATTDTDPALDVRQETLRTPSAWTRLRDSLVESVWGLPQRSEGCESRPRNRAKTVSRAPATLQARYGEDVVLRFTIKNQEEVKALVEASNILFLDVWGSHDDWVDIRLSRDVIPSLLGLLPPSLQTSHVPLIRDLAQTIYESYPKAGSAPPSQQGPTTRRFSPSASTSKSKPHEAKNIFFQDYQPLSVLLPWMRLLVSMFSSHTTLISVGTTAEGRDIPALRVGVHPTNNAQQAPRRRTIVISGGTHAREWISVSTVSYIAYSFITGYGKSKSITKLLEQFDYVFIPTVNPDGYAYTFSTDRLWRKNRQQTSLSFCPGIDLDHSWGYEWDGNATRSNPCSESYAGDQPFEAVEAREIASWARNEVTVNNVHFVAFVDLHSYSQQILYPYGHSCAHLPANLENLEELGAGLAKAIRKSSRENYDVKAACRGIVASCTGDKDADEPVTSSALERTAGSALDWFFHDLDVRFSYQIKLRDRGSYGFLLPREHIVPTGKEIYRAMVAMGKFLVSPHVLEEDIDGLRASEEPQDYDNDLEDGEDDKDEQDSTVFRAQADDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIZ8</accession>
    <name>D4DIZ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosyl-DNA phosphodiesterase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018803.1">
        <property type="nucleotide sequence ID" value="XM_003018757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIZ8"/>
    <dbReference type="GeneID" id="9581380"/>
    <dbReference type="KEGG" id="tve:TRV_07162"/>
    <dbReference type="HOGENOM" id="CLU_007773_0_1_1"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48366" checksum="4FDA548AAB6A448A" modified="2010-05-18" version="1">MDHDLQAAIDASLRDAVRSQTSLQRRKSSVVDLTGDSDGDASAARRAGKAAEEEAGDDDYDAELKRAIQLSLQSGRGPEHETIDVDTLEAGKATATPEPKRAASTWIAGFDRKKMEEERLARLAKKRKTGEDGSALALPAARPLKASRREPPSGTSSSSAKISSIPPATATVAAKSVPGVPSTEPTIQFPEGAVKKTWAFRCERKDDIKLEEVLQPSDLELAVLSSFLWDMDWLLMKFTNPSTRFLFIMGAKGEERRTQLLRETASMSRIRLCFPPMDGEVNCMHSKLMLLFHANHLRIVIPSANLDPYDWGEKGGVMENMLFLIDLPRKANETIDDTTPFRDELVYFLRASTLNEKIIDKMLQYDFSKTAKYAFVHSMWVLFLFIFLLFFPFALGVKLRCLNTLTFFFIFYFDFDFLQHLKFCFELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI3</accession>
    <name>D4DJI3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018661.1">
        <property type="nucleotide sequence ID" value="XM_003018615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI3"/>
    <dbReference type="GeneID" id="9580814"/>
    <dbReference type="KEGG" id="tve:TRV_07351"/>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="207"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="881"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="963" mass="105811" checksum="7B9A9A5258A356B8" modified="2010-05-18" version="1">MAGMEELEIHSKPHKKSLNFGIFKHPGASGLAVNSAASTYSQTTGSDINDLSKENNGPAKQTDSSLLITEKLKGVGLKPIEWIGKCEADKISQGTYDVGASEGGNYALVFDNTFSKQISKTVTFVLLTYPTSCPPRSGHQVHHTQAIAGPIGSQAPSRPSPKLNATETEAEAKARAQQRGRPGFGAAAAGNSNGPLPTTDSSTSIAPSVHTGILSKRRRKRHQGYARRFFSLDFNSSTLSYYHDRNSSALRGAIPLSLAAIATNENTREISIDSGVEIWHLRALNNVDFQAWKEALEKASKQGDTAGEEDGSLKVPTLITRKHSVNKPKSQDWKTIERLVESVSASREKVRQLAKDTDPKYLMPTPDYEGNQSQANGVRRVSQPGDVSESKEKRSFWKLKGKSDSGSSTPNQRPALSPLGPQQTPPLSNEGSYFDGSSFKSGLGAGVHDDLMILLHDLNAVVSEFNALLSDRTRSRTPIAIRPAHSVTADSDSEEFFDAVDGGNVSPLLTIHQDSGEEDSKSVVTAVDDDAASSSGSDVDDRDEFLRGDFKLDSSSSLFPVKARSLAPLPMDAPPRRSRIEPPIGLPPSLISFMRKNIGKDLSTISMPVSANEPISLLQRAAEQFEYSQLLDKAANATDALERLIYVTAFALSQFSNSRIKERTVRKPFNPMLGETYELVLPERGFRFIAEKVSHRPVQLAMQADSRDWSFIQSPKPTQKFWGKSVEIITEGKSRLTLHSSGEHFSWSAGTQFLRNIIAGEKYVEPVGEMCVLNETTGQKTIAVFKVGGMFSGRSEEVTVKAYDTHGEELPLGLQGTWTSSLQLTEHGNLTNKTIWAAGPLVDKPQKHYGLTEFAVALNEITAVEQRKLPQTDSRLRPDQRALEEGNVDEAEDIKARLEEAQRFRRKEMEQSGETWRPRWFTHVDVDGLDGGDDIWKLRTGKDGYWEERAKGEWTGTTPIFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJK1</accession>
    <name>D4DJK1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018609.1">
        <property type="nucleotide sequence ID" value="XM_003018563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJK1"/>
    <dbReference type="GeneID" id="9584536"/>
    <dbReference type="KEGG" id="tve:TRV_07369"/>
    <dbReference type="HOGENOM" id="CLU_000288_120_0_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000465">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="294"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="576"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="661" mass="73418" checksum="6FD32BFDE686B1DC" modified="2010-05-18" version="1">MSWKLTKKLKETHLAPLANTFSRSSTASSPKAEPSADEGAPLSKTPTASSSTSSIAASEATANPPTDSLKPGILIVTLHEGKGFSLSPHYEQVFNSHYQSSSGSYSASMRPSSSSHASHIPNSFAHPIRPQSTSGGINAAPTNHGRYSTKHLPYALLDFDKLQVFVDSVSGTPENPLWAGDNTSFKFDVSRVTDLNVQVYIRNPAARPGSGRSDDIFLGACKINPRFEEPRRFVEDPKASKKEREKAAAAFAQKEKQLGQLGSEWIDLQFGTGSIKIGVSFVENRQRSLTMADFELLKVVGKGSFGKVMQVMKRDTGRIYAMKTIRKAHIISRSEVEHTLAERSVLSQISNPFIVPLKFSFQSPEKLYLVLAFVNGGELFHHLQREQRFDINRARFYTAELLCALECLHGFKVIYRDLKPENILLDYSGHIALCDFGLCKLGMKDEDRTNSMYHKPEPFCLPPFAFVNGNLSLLAFCGTPEYLAPELLLGHGYTKAVDWWTLGVLLYEMLTGLPPFYDEDTNEMYRKILHDPLTFPGPEIVPGAARDLLSRLLDRDPHRRLGANGAGEIKGHHFFANIDWRKLLQRKYEPSFRPNVADARDTANFDVEFTSEVPVDSYEEGSGLSRTMQKPFEGWSYNRPVAGLNDGGGSVRDPAFGSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJR2</accession>
    <name>D4DJR2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018585.1">
        <property type="nucleotide sequence ID" value="XM_003018539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJR2"/>
    <dbReference type="GeneID" id="9584514"/>
    <dbReference type="KEGG" id="tve:TRV_07430"/>
    <dbReference type="HOGENOM" id="CLU_573891_0_0_1"/>
    <dbReference type="OrthoDB" id="4207736at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="476" mass="51810" checksum="62467F05D87E22F0" modified="2010-05-18" version="1">MALPAHRSHTCNLKYDTSARPSEMGSIFSDHASYTPLGHLDSTPDYWSSISSIDDDTLSIAPVSQQARLEDIIGITLERTCYGFAPSQGRRCRNPIAQHSLNNALGLLNLGNEQLCNGQDISQTLERLATLVLCRRNHQYQAVTVARRWAEMVASSLAQGQPAYVTPTRSPPSQRQSAYASQPRTRRVRVPIPPRSVVFGGRTSDQRDTSSGHTTVVPVPRPTISRQSTSQPPIAHLPTAQSNSSRTTPVRYGTRKFIKPNEDCPRNGNDRLAITFNLAVPAEEEEEEEESTTDSNDSRNTTQPLPYASRGSSEQDSSGQSNEEQLEDEETSSEDSNPAEENPVAYTLSDNGGSAASSIEAVDQVEPGGAGTDLENPNIEYHTLLPENNNTSTSALIPAPDSTGETPSQPILEQYISPSVDSSIAGTYTHAATQTEISIPKYINRDDKDDDPDHGCCLGPLVNIWHRVSSTLLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJW8</accession>
    <name>D4DJW8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018497.1">
        <property type="nucleotide sequence ID" value="XM_003018451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJW8"/>
    <dbReference type="GeneID" id="9584426"/>
    <dbReference type="KEGG" id="tve:TRV_07511"/>
    <dbReference type="HOGENOM" id="CLU_367688_0_0_1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="758" mass="84778" checksum="0BE365AAE9DAB64A" modified="2010-05-18" version="1">MVAGELAAGPIGSPLPASRICHSRRSKLLPLCRQALCFFLLPFSPFLLLTTWMGPRSEDMPLPPNHRLADGNIKRLPQSTSRRTSTKAKWRVDMAPPIARAWHPVRHWAWYSLFFLFLPVFALALFFFIFLVLELEALGLLLVSVAMQIWENRHQKTQSPRDQRPFNQRIYTLMLSRCLLNIPSPRFLFDGRCFVCSSMVNSSNTTSSIINRITLPIMILATVKESVRTSWGMFSAVERRNIFLYILGIAFYKFGLEAFNGSILALATNRYDYDAYLKHRPAKTFERVGLLSGLNQACQCVGSIMIAPLVRRAPARLVLVVSVVLFGLFTGILMVVDAATGGTIMPPEFRGDHPAMDFHYYGDYNTDGIIPIYCVTGLVYGMVELIRRIIPRDIVGGNIQKLRRLDAMVHVFYETSGTASAFCTALALIPTLGNNYSFIITPVFFAMAGATWFFIKEADTFQPPPPPLMGKRPTYIKAVFVSFYLFGESIWTGSKLLLTNRRFIWLIPGYSIAFYGHRYLENGLAPAVARRYLGHSAWANIIVGGSNLGELLGALFVFLFTNLVTTPIPWVRLDAVMLLGVWYLSFWTPPPDQVAYAWIIGATFLPISFGWAAGDVSLAAYIQAALARHESKAQNVSPLGAVMACLYTTYIVTYAITSPLLGQYIDSVYIRTGGRDGGDIHSAIHNVAGVQYSVMAVIIFASTFIPQGAWRINPKMLFNQNLDADLEVTEIGDGIDLKKKSHERETSLSTNPRDRESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJX8</accession>
    <name>D4DJX8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018473.1">
        <property type="nucleotide sequence ID" value="XM_003018427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJX8"/>
    <dbReference type="GeneID" id="9584400"/>
    <dbReference type="KEGG" id="tve:TRV_07485"/>
    <dbReference type="HOGENOM" id="CLU_1636644_0_0_1"/>
    <dbReference type="OrthoDB" id="10419248at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055628" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="162" mass="18211" checksum="AA1683EC70652259" modified="2010-05-18" version="1">MHLFNLSAICLVAFLAQTCLCLTGNFTFLENYNHDGLTISPLDGLVEIKPNATDIWRIEPIPPDRGSHIIRHPKTNQFIYFRQTEDGTTATLSKNAATVITIAANNPYHCLLYGLRLRSSSGSPYYCTMEANSNTDPRQVLRLYQKKPAVDFAFLPEAFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK84</accession>
    <name>D4DK84_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018369.1">
        <property type="nucleotide sequence ID" value="XM_003018323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK84"/>
    <dbReference type="GeneID" id="9584312"/>
    <dbReference type="KEGG" id="tve:TRV_07605"/>
    <dbReference type="HOGENOM" id="CLU_2549372_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="83" mass="9116" checksum="29FA3BAE6A2AEF40" modified="2010-05-18" version="1" fragment="single">NLLRYCALGFSERQRVGNPLRRIEGGGGLVYDSSIEVDEADERAGEADDDDDDDDEGLWITGPRDLAAFEIPETTEAYLPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF8</accession>
    <name>D4DKF8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018301.1">
        <property type="nucleotide sequence ID" value="XM_003018255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF8"/>
    <dbReference type="GeneID" id="9579997"/>
    <dbReference type="KEGG" id="tve:TRV_07680"/>
    <dbReference type="HOGENOM" id="CLU_324440_0_0_1"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055604" evidence="2">
        <location>
            <begin position="21"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="890" mass="93258" checksum="8932FE847EA4FFB0" modified="2010-05-18" version="1">MRLTTSVLLWAATSVLQADATQTYRSPTGPEAYGAYPPRYTVSYTTITSTSTIHSCPPRTTTIFTSSPPPDDGCKFPGCPNQPPKPGSDVHCDIYCWAKGCSLCKNDTCPEQGGIYKRREDMKNIFGRSSGSAEGYNYTPETTCCCCCEPGGGKHTVTVTKTKTETKTETASITKIITDYVTKTVPIPTTVLEPTTIIDPTTVPTTVPTTIPTTVYNETTIHDSTTVSTTVIQPTTISDTTTLTTTFTTVVPTYITTTTFGTVTSVVTVMVPTTITSTYVSTMYTTLPGTTLTTSVTVPGPTVTPPPVTLPPETKIITLPASTVTKVTTLPASTMTVTSTLPASTITQSGTTVTLPGNTTVITSTIPASTITQTYTEPGTVSTITSTPPPETHVITLPGSTITKVTTLPGTIMTVTQTLPASTVTQSGTTVTIPASTTVITTTLPASTITQTLTEPGKEITVTKTNTVTTTTTSFSISLCPTRTANPTYTPLAPLPSNYIWGCPPGQLCRPKRTPADGQCNFEVGLPSQNFVCSPDECIPSPPRHPPQKWTPGKVEKWVVSPGYFNIDPRKFGLTFDIFSFENVTATSQGYFRRSLSALFKRGPEIVAGECYDECDSAATEAEAVGADPALCKPDSLFMKLVGQCKKCTNDRSNGTYSEFDTVLFPEFQKWLDYCDTLPIPSGPTTRPEPGMTSSTTSSPTHSTVITSMTSMTTSESSTPTRSSSTVTTSETSSPESSRSSSESSTESSTDSSTTERTRTTSTAESTETTEPTSTDASTESTSTATHSSTGSDPEPTNTRHPPSTASGSTTTRSGGGGHGSSSSEGPIPTSMGTPTTTGGGSIPSSGTGIPPSSSTDPVPFPGGAGSLSPSTWGKAVTCISSMALLVAFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKQ4</accession>
    <name>SUB8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Subtilisin-like protease 8</fullName>
            <ecNumber>3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SUB8</name>
        <name type="ORF">TRV_07778</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-"/>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018203.1">
        <property type="nucleotide sequence ID" value="XM_003018157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKQ4"/>
    <dbReference type="SMR" id="D4DKQ4"/>
    <dbReference type="GlyCosmos" id="D4DKQ4">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9579574"/>
    <dbReference type="KEGG" id="tve:TRV_07778"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000406382" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000406383" description="Subtilisin-like protease 8">
        <location>
            <begin position="135"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8" evidence="3">
        <location>
            <begin position="144"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="490" mass="52363" checksum="CFF02C25618ED80A" modified="2010-05-18" version="1" precursor="true">MKGLLSLSVLPVLAYASPMIVDSIHQNAAPILSSTNAKDIPDSYIVVFKKGVTSTSALAHQNWVQDIHTSVESKRMKKRNQFTFKNEAFDGLKHTFDFAGGFLGYSGHFDEEVIEQVRRHPDVEYIERDSEVHTLKAATENGAPWGLARISHRDKLNFGTFNKYIYASQGGEGVDAYVIDTGTNIDHVDFEGRASWGKTIPQGDDDVDGNGHGTHCSGTIAGKKYGVAKKANVYAVKVLRTSGSGTMSDVVKGVQWAAESHLKSVAEAKKGNRKGFKGSVANMSLGGGKSVTLDRVVDQAVAVGMHFAVAAGNDNADACNYSPAGSKNSITVGASTLADERAYFSNFGKCTDIFAPGLNIQSTWIGSKHAVNTISGTSMASPHICGLLAYFLSLQPASDSAFAVAEITPAEMKENMISIASKDLLSDIPSDTPNLLAWNGGGSDDYKKIIGGARENDTTEFSSTLTEKLEKLAEEGLTAIYNELKDAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ9</accession>
    <name>D4DKZ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000485">
        <property type="protein sequence ID" value="EFE37471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018116.1">
        <property type="nucleotide sequence ID" value="XM_003018070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ9"/>
    <dbReference type="GeneID" id="9579327"/>
    <dbReference type="KEGG" id="tve:TRV_07873"/>
    <dbReference type="HOGENOM" id="CLU_051198_0_0_1"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="476" mass="53568" checksum="93FBCADF2C331522" modified="2010-05-18" version="1">MLPSIDPPQAEMKPASKYSLMEQVETPCGNLLVTGGSEEYSAEYPPKIATFYYLGELNDEMKPIYSQGNGRSFTIRGNVYHIFGKTIWKDAKGEVVGEAANSLALVSDPEVNPIANIAMPISRGMAPFLPLTKNEEELEKSHNHKIVLEMPGGFCKPEPDAIGGYIWFQKYIQIRSTEGIVETAFQGVSLAIAVRNRHTEEVRAERIMHDELLFTDSEPAFGSFCSVLESYYFYVWGKLGEDIYLARVEKYEPQNRSAYEYWDGYNFTQDISTAVPVFSGYSSGTIMRSKIFGHLYNWMFIGGTESNMPVVTIGVAHDIQGPYIMHSLIKSEHVHPMLRQVHSVYAHHWAYTERDGQLLITWNERKTGNIIGTKLQFSMSAISSMIMDGKELIISFARAKKAACRIDYDMDGETIIRVFSGDVESVNAAVDSICNLIRRWCNEFLDEGKAAKASSSLKGMLRWPFSIFTSLSLQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLL2</accession>
    <name>D4DLL2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_08086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017920.1">
        <property type="nucleotide sequence ID" value="XM_003017874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLL2"/>
    <dbReference type="GeneID" id="9579798"/>
    <dbReference type="KEGG" id="tve:TRV_08086"/>
    <dbReference type="HOGENOM" id="CLU_045732_3_1_1"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="420" mass="46965" checksum="F22C56B4D26849F9" modified="2010-05-18" version="1">MAPSDDLKSHAASSHDFYGLLGLNPTAVDSEVRRAYRRTALKYHPDKIANPTPADIEKFHLLQIAYDVLSEPPVRQLYDNAREARERKKRENELLEGARRKMKEDLEARERGVKRPWGFTGSGGDHDDLQAADDKLEQEIRRLAEDGKRRRREKEERMRSQVLEEEERLEREKEEPEAKKQGTSKNGATPINVGGTTVPEIDRTVKVRWIREGVGLDMDKAKLESLFSTFGKVESAFTLKDKRQRVGDQREKKTVATGVVVYSSVVGAHAAVEDRFKHKGDAWEVIESVAWASNKQPDWDAYRASSPVTTDMHSKAEASAGAAASEPDNLHPPSPNRPKRFTMADLDPRKEKSEDVNKVGKAPSFGSFSSANAKGGFGASGPSLEELTLIRLKNAERKRLEEQIQKEDEAAALADAKSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLQ6</accession>
    <name>D4DLQ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_08130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017874.1">
        <property type="nucleotide sequence ID" value="XM_003017828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLQ6"/>
    <dbReference type="GeneID" id="9583769"/>
    <dbReference type="KEGG" id="tve:TRV_08130"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="116"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="442" mass="48165" checksum="6B1FB9803E4254FD" modified="2010-05-18" version="1">MLNFDIDPRRSRLRDPRDHLVSSTSRQQKKRTSTFFATKQAEAADEEDDDDDDARPAARSTRRNPEAAQILRPASRLLAPRSSLPAARFSAFRPAVFTQPVAQRRSYAAPSGVKEVTVRDALNEALAEELTSNEKVFILGEEVAQYNGAYKVTKGLLDRFGDRRVIDTPITEQGFCGLAVGAALAGLHPVCEFMTFNFAMQAIDQIVNSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYAAWYGSIPGLKVVTPWSSEDAKGLLKAAIRDPNPVVVLENELLYGQSFPMSEAAQKDDFVIPLGKAKIERPGKDVTIVTLSRSVGLSLQAAAQLKSKYGVEAEVINLRSVKPLDVEAIVKSVKKTGHLIAVESGFPMFGVSSEILALAMEYGFDYLQAPAIRVTGAEVPTPYAEKLETMSFPQEDTILSQATKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLS4</accession>
    <name>D4DLS4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAP family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000518">
        <property type="protein sequence ID" value="EFE37208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017853.1">
        <property type="nucleotide sequence ID" value="XM_003017807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLS4"/>
    <dbReference type="GeneID" id="9583747"/>
    <dbReference type="KEGG" id="tve:TRV_08148"/>
    <dbReference type="HOGENOM" id="CLU_038163_0_0_1"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50696" checksum="FAE786A4FD2F5172" modified="2010-05-18" version="1">MYNSANAAKLTKKICLFPTLKLRPSPASHQPSTIIKHQLQLQLSIGHRDLAGDATLGYTDMADAGDDQVPLLERVEMPSKLPKELQREMTLLQDEFADAQVEHMRVGVNLMRPVYAKRNELIASKLKDLDFWPRVFSNLPAEIDEFILPSDAQILASCLKNFNIERIGVDEATGQGEPRSLRFTFEFDTGDDNIWFTNEKLVKDFHWRRELKITAAGKRRVWEGLVSEPVRINWKPDMDPTHGLLDAACDLAEAEKAFIKKEKKDKISEDERMNLPEFEKLVELAAKVEAQAAPDNEGEEDGDEDGASPAGLSFFAWFGYRGADVSEKESEAARKEDKETTEKRRKGEDIPGEDDDDDDDDEEEEDSLAIAEIFADGQNVAIAFGEEVWPEALQSYVDSYMVPDDFEDFDELDVEEMEALVAGGEDDDDEETGEKADKEERPRKKAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX1</accession>
    <name>D4CYX1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025805.1">
        <property type="nucleotide sequence ID" value="XM_003025759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYX1"/>
    <dbReference type="GeneID" id="9582048"/>
    <dbReference type="KEGG" id="tve:TRV_00008"/>
    <dbReference type="HOGENOM" id="CLU_1428956_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="190" mass="21242" checksum="931C24C532E39582" modified="2010-05-18" version="1">MSSASPPKEPEVEPVTQSGDEAEPMEREHHDIQTQGQGEFEVKEQDRWLPIANGLFIPFSLLALLLSIPSSSFVEVTHLPYLTTFSSLNSFRTQKKPRLARKKDTPKGLDTNTSRRQYTNSLLSSPKSLLQGKDSLMSMLSPPLLPKASYMRIQSISLKLMRCNLESGCSLVQSPKTSISPMLLLPHVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX4</accession>
    <name>D4CYX4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025808.1">
        <property type="nucleotide sequence ID" value="XM_003025762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYX4"/>
    <dbReference type="GeneID" id="9582051"/>
    <dbReference type="KEGG" id="tve:TRV_00011"/>
    <dbReference type="HOGENOM" id="CLU_006329_4_0_1"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="697" mass="80285" checksum="50CE789B5E27DD81" modified="2010-05-18" version="1">MSVLDITAQHQHQHQQHHHHQQQQQQQQHRQRQQQQHEAQLEQDRDQKEGSYPAASVMDYRDISPDEEESSERDKQLAKLIDDESTHRKIQKNVRVIYVGQDVSNLNFLLRQQHVDRDDEVYHFATNEISRKYIECGFEQVPRDAFVLPEPALADELVDAYFKHVNPGFPILAEDIFMAQYKGRDSSDAPSLLILQAVLLAGAHVSRPRPMRDTLKAAFFRRAKLLFEARVERNRDIMVQAALLLTWYSDPVDDDVAANAHYWVGVAARIATGLGMHRNSGSSIFVPHDKRMWRRAWWILVQFDVMVSLQYGRPQAINLDDCDVEPLREADFEGCGNNIQKDYVIQFTELCCMISFIVRERFGLRIAPERRKSILSEADKALANWSIKLPDTVRMSTSDMHAWPALLHLTYNNFLILLHRPHPRASADTYAHNDAEICSAAAGVIVSIFEELREKDRVKYLWSSAVNTLFTAMIQIRVELRFFNPVLAINALRRFDSTLVSLRALSEYWHNAESILHLFESSKRLKYDMQMVKSKQTNASLPHKEGDSVSKSTEGPSPQVEAPLPPPQLHTWWPKAQLGERLTYFSHSEPMGPVSAPHHPHPQPQPQPHPQRQSQAQAQPQPQPQQQQPQQPRARASEHIPSPGQGPDWRQLFTFESDACGAVVPENLNDMEDEWRELYLHDPGLTDYFQESTWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ13</accession>
    <name>D4CZ13_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025788.1">
        <property type="nucleotide sequence ID" value="XM_003025742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ13"/>
    <dbReference type="GeneID" id="9582031"/>
    <dbReference type="KEGG" id="tve:TRV_00050"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE45177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="542" mass="59652" checksum="403AFCDB8ED05F19" modified="2010-05-18" version="1">MADTILPRHSPRADIELANDSHPEKSCETPAKDGQAPAAVDDGDDGDGAMVQAVEYEEERILCSRLDIRLLPVLAVMCMFAVPSASSADRRRLIEADLFNALDKANIGNAQTNGLSEDLDFADGEYNLLLSIFFIPYVIFAPSIAMIGKKYGPARVLPICMFCFGSLTLLSAAVHNFGGLFAIRWLLGMAESAFLPLVIYYLTTFYRRGELARRLAIFYAASNIASAFSGLVAFAAFQLPSTRLEGWRYLFLIEGACTVCFSIFAFWYLPHTPAQARFLTAQEKTLAFHRIQVDSSSVVNEKFSFRDALGVFKQPTSYCFILIEICLGVPLQSVALFLPQIIQRLGYGTVKTNLYTVAPNCTGAVMLLILAFSSDAARLRSPFIVLGFLLSFSGFMIYASIDDVKNNIRLAYFGAFIMTWGTSAPSVLLSTWYNNNVAHEGRRILLTSVGVPVANLMGLVSSNIFRGKDSPKFEPALITTAVFGATGCRSSRSLATSIWSQTSNILPDSSSFSYFDALMLKLPKKKVNEKEKKKPIKVIYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ52</accession>
    <name>D4CZ52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025718.1">
        <property type="nucleotide sequence ID" value="XM_003025672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ52"/>
    <dbReference type="GeneID" id="9581961"/>
    <dbReference type="KEGG" id="tve:TRV_00089"/>
    <dbReference type="HOGENOM" id="CLU_1644945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="17904" checksum="00847E1467566B49" modified="2010-05-18" version="1">MRDVRRRERIAGLKRVSKKASKKHEVGAALGSTASVQRQTDDQEESATGAVADVRPPPSWVAFKSKDESKVLYIFNNPLTTAVYQTLDPMDTIKGFEGIGNVVGNLVHYINHCLIPMTFPIEARKEEETKKRLAIMRVAALSSSASFFCPDDPQRRAQSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ55</accession>
    <name>D4CZ55_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025721.1">
        <property type="nucleotide sequence ID" value="XM_003025675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ55"/>
    <dbReference type="GeneID" id="9581964"/>
    <dbReference type="KEGG" id="tve:TRV_00092"/>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="305" mass="31840" checksum="7D9F32C28A09B6E8" modified="2010-05-18" version="1">MAGFYQQQQHQPYGVPPQQPSAQNLQFYPSSYSSVSGHTTPAQVSYGGYGGSSSSSAYPPLGSGGASFGGSAGFGGGADAVSGRMGEQGGLRMGWLAAFGTEGYEDEPPLLEELGHLMDDNDLYGALLYILLYGTFLLLSGKVFYGYIYGVAVFGSVIIHLILSLMSPTLDPSTNGVSHDSTGMNMNMNPSDAGHGHGAQGGHFSSTLTFPRSASVLGYCFLPLVLTSLVGILIPMDTVFGYLLTTAAVGWCTYSSSGMFCAVARMRGMRFLVAYPLALFYVVFGIMGIFSSRGGGTLVAKATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ96</accession>
    <name>D4CZ96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">TRV_00137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000006">
        <property type="protein sequence ID" value="EFE45076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025687.1">
        <property type="nucleotide sequence ID" value="XM_003025641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ96"/>
    <dbReference type="GeneID" id="9581929"/>
    <dbReference type="KEGG" id="tve:TRV_00137"/>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE45076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="54619" checksum="908009017CE3F0B1" modified="2010-05-18" version="1">MRSLLGGALRPYICTSCKRGLQAQRRRFASSLSQQPDIYDIVCVGGGPAGLALLTALRSSPITSKLKVALVESQDITKAKSWNLDSENFSNRVSSLTPSSVAFLKSIGAWQHIDSSRVQPYEEMEVWDGVTGSNISFNWPPGLIDHDASSKTIATMTENANLIRGLLTRIESLGNDVSIFSSTKVTSINNGTDIPDGPDLSAWPVLTLSPSSSTETTSKLPTIAARLLVGADGINSPVRSFAGISTDGWDYDRHGVVATLKLSHSAASSSRPVTAYQRFLPGIGGPVAMLPLPNNFATLVWSTTVQNAAYLKSLSPEAFTAMVNAAFRLSITDLKYMFSLPSSPNQTSSETIYGHADELSWRLQHTPVPSYVPPEVETVHSNTVAGFPLRFRHASTYISPRVALVGDAAHVIHPLGGLGLNLGVGDVISLHRAIEYAVQHGMDIGSLLSLEQYAADRWITNAGIGGACDLLHKAYNVPGYGPFAWARGVGLSAVNSLSALKEVIMKRASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZT9</accession>
    <name>D4CZT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025463.1">
        <property type="nucleotide sequence ID" value="XM_003025417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZT9"/>
    <dbReference type="GeneID" id="9581699"/>
    <dbReference type="KEGG" id="tve:TRV_00332"/>
    <dbReference type="HOGENOM" id="CLU_000288_165_0_1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="706" mass="77856" checksum="3E7CD1507F3FD74A" modified="2010-05-18" version="1">MLDTLLPHAYVKETLNAQSTYTNSQDDNTAEHRINQYLIKQEIGRGSFGAVHLATDQYGQEYAIKEFSKSRLRKRAQSHGLRRRPGRHPGVQPAGVGFNSPLHRHPSGIDEGENGNSLYLIKEEIAIMKKLNHSNLVSLIEVLDDPTEDSLYMVMEMCKKGVIMKVGLGEQADPYSEENCRCWFRDLILGIEYLHAQGIVHRDIKPDNCLLTNDDVLKVVDFGVSEMFEKTSDMFIAKSAGSPAFIPPELCVAKHGEISGRAVDVWSMGVTLYCLRYGRIPFHTSNIFDLYNAIRNDKVELPGETNEHFKDLMTKILEKDPAKRITMPQLRAHPWVTKDGTDPLLSEEENTATLVGPPTEEEMDTAITRNLGHALIVVKAVQKFKRLINDGSPLQMESILGEGEESHFVQPPLLMGEEEEEEFSAVLHHRNMQEHVYPRRPTQPKRPSQATTDNSPLVSTPPLEICTSPSPQLQSTPRADTPMRQTGSEGTRGHARDPLEEEMPFLHIGPSNFGPEAELNQTKQDDSPLESGGIPIPARPTLTESPMVVSESPPAADIDIYETAYKEIIERITSRSRAAQSPTPRVYLNRRVDKKATASSGLWSQVRRNSKLAGVPSPSTATPVPGSPPPRPSPIKRFTAAAASFAVSSGRQSPSPSPLATSVKVNDVVDSDKVVESSPLDTSAAVIETTASPTALSPVDDAKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZW6</accession>
    <name>D4CZW6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025490.1">
        <property type="nucleotide sequence ID" value="XM_003025444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZW6"/>
    <dbReference type="GeneID" id="9581727"/>
    <dbReference type="KEGG" id="tve:TRV_00360"/>
    <dbReference type="HOGENOM" id="CLU_1361297_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22802" checksum="67C224658E6289E7" modified="2010-05-18" version="1">MPAGFVTKPATAARKETAGKQCNPDFSGTNILRCYACRRPWFVSQPASQTELTGWVWSSFHHRLAQSFSSVPTFARWTNQRLTHDPCAPLQQTLFQPHLFDFISSSSSSSFHPIFFVFIFIFIFTIFCRLDYSLSAASSVQVLASRRWSSRTPRRRSELPVTASLTSLDLPRLPRSSGCGVFHIIYIGFQVFFLDSEPFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D023</accession>
    <name>D4D023_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025356.1">
        <property type="nucleotide sequence ID" value="XM_003025310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D023"/>
    <dbReference type="GeneID" id="9582967"/>
    <dbReference type="KEGG" id="tve:TRV_00417"/>
    <dbReference type="HOGENOM" id="CLU_056425_0_0_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="246" mass="27951" checksum="EE1753DDDD945604" modified="2010-05-18" version="1">MHEVVDNDTDRCMVLEYLDADLWSLRTRAQKLGEPFLKAAAKSILEAVKVFSDMDGHITALHTDINPNNVLVSKADSQKPIIKLADLGAVIPSQGFDDFRLQGTEIRAPEIWKGVLPMPPCQIWSIGVTLTHFVANRVIFGNWDQDCRVQELPLEVDRCAWAIGKIIKLVGRLERDEDPKYQLEFALAELFVQKDLIKARSLEEELAKASVPEDCVHFLRYLLHLDYKTRPTADQALQHPWLQNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0K1</accession>
    <name>D4D0K1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000034">
        <property type="protein sequence ID" value="EFE44619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025230.1">
        <property type="nucleotide sequence ID" value="XM_003025184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0K1"/>
    <dbReference type="GeneID" id="9580722"/>
    <dbReference type="KEGG" id="tve:TRV_00596"/>
    <dbReference type="HOGENOM" id="CLU_010672_3_0_1"/>
    <dbReference type="OrthoDB" id="4199792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="562"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="757" mass="85083" checksum="472A39247225996E" modified="2010-05-18" version="1">MEKQIQELLARAEAAERRQQEEQRRREEAERLHQEEQQRRLEAEAQLQPVPLPVFLQSCHELLLSINIVTDPTKTTKGPVTKPANRRVPSRMLIWDTFAEEQAAVWEKLYEHPSFLEEKLFPSEHQLEYVRQFISPINSEMDLRYFERETVENHVRIIIDRITEHEDLKAALGLRGSVTFESHTNLGATKKKPLQREEARGTLIDEAAAAETGPPAAASQGSNSQTRDAITRGQADRFCIYRQEGDEHVPAIAIEYKAPHKLMQTEIATGLTQEIQPARDVIDKESDDTEFYCKRLVAAVITQLFSYMVLKGVRYGYVCTGEAFIFVYILDDPSSVQCSVCTPSQDVKGTDDKDLQSTAVAQVLAFTIKALSSPPVSQQWHDAVDGLDVWPVEYADILEQTPPDSRPKRISPPYRGRRPRDLPRFRMSLRSRCRPSEDGDRSSSSPSPSPSASSSRLSSTVRRARAKKKAALRSKSSGKSTETPNQKETTNASKFPIFAPIPAIKTRPYCTQQCLLALRNGGRPDTSCPNYRDHQNYKGKIRPGNFRSLIRTQLATDRGPDADCRPLYKVGSCGALFKVRHSSSGHTLVAKGVESWNLHKLKHEMQIYNKLKSLQGKCIPVCLGIVDLVPKFPYYFDEGIYTHMLFLSWAGESISKTGVVPQDADVSTMVHNALQSIHSKGVLHGDAEPRNILWNPTSQHVMIVDFERSVIQNALSDVSANSGSKKRKLADTCFTKELQRIDAVFENKAPNARVGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0L1</accession>
    <name>D4D0L1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000035">
        <property type="protein sequence ID" value="EFE44610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025221.1">
        <property type="nucleotide sequence ID" value="XM_003025175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0L1"/>
    <dbReference type="GeneID" id="9580719"/>
    <dbReference type="KEGG" id="tve:TRV_00606"/>
    <dbReference type="HOGENOM" id="CLU_669381_0_0_1"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="411" mass="45348" checksum="7EDED2BAAD0F23F0" modified="2010-05-18" version="1">MDELALPFPFEVAVSRYPSLHRSPATNRRSITTAAPSSYVDTGSLWEVPDDQPNQTPTGYQFHSTIETIPKEHYELDTVLEGPEQDVDPISTIEEAPRNCENIYPEGQNVLRLDHGLDPAIDVEEAPRIQDDIIQGDENIHPIEPTHTSPEGVSPSQPQNVSIVEPKKRSLNRAKKNQKKKVKRGKTTSAVVRKTVESDVEDDVIWINEEKPRSAIIDDTDASDDILDLNDNDNLFTPNSLAHEAELVPKSLPKIEVQVQVPTNVADKSGQAGPAPKKRGRKRKKTDQEDISHQKSPPRPVESIISDDSVENRNNNIIPSATPPPLSSPAIVNQQTPEPKADNHNLHTSVEISESSVDKKIEPAPPAETPKKPTVKGPDKHSPIAVTAKVAYRVGLSRKARIAPLLKVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0M3</accession>
    <name>D4D0M3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FRG1-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000036">
        <property type="protein sequence ID" value="EFE44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025213.1">
        <property type="nucleotide sequence ID" value="XM_003025167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0M3"/>
    <dbReference type="GeneID" id="9580706"/>
    <dbReference type="KEGG" id="tve:TRV_00618"/>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28664" checksum="77F98A4B928958B4" modified="2010-05-18" version="1">MVKPLSFKGDKKTKKRKRQPDDNEGSATTEPSKTSAADIEATADDNGQNWVSADIPAEIAGPVLLVLPSTPPSCIACDVNGKVFASELENIVEGNPGTAEPHDVRQVWVATKVVGSEGISFKGHHGSANSSAISALESFVPISCPNSPGMISLQICGGDIEAFISSKETPSAASKPSIEIRGDATEISFNTSLRVRMQARFKPKTKSAAAKESKALEKISRKELEEAVGRRLDDSEVKRLRKARRKGNYHEEILDVRVQGKHDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V1</accession>
    <name>D4D0V1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP transcription factor JlbA/IDI-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025118.1">
        <property type="nucleotide sequence ID" value="XM_003025072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V1"/>
    <dbReference type="GeneID" id="9580626"/>
    <dbReference type="KEGG" id="tve:TRV_00697"/>
    <dbReference type="HOGENOM" id="CLU_901844_0_0_1"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="30262" checksum="B5FDC9E2D771CF0D" modified="2010-05-18" version="1" fragment="single">SLFSHPSLSSSTSISSHFSPFPPTSSSLAPPIADSSSPFPSPDHFAAFFPDHTTYLAQDQYPLSTGQNILDLSSQSWELYDDPLQALLSTEELDLSNSQSQILTPSIDHSPIQTPVSKNGSLHSMKDSDPYLLDIHIAGDAGDSFRDVNNVPTITTRNSARTPLSRPEFSSTTVPEIGLSPESSSSSTTKSNSNRKRPRVDDDSRSTEEIANEKRHRNTMAARRFRKRKEDRICSLEKQLADALRERDELKLQVARLEGQNMMLRTCQDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V4</accession>
    <name>D4D0V4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025121.1">
        <property type="nucleotide sequence ID" value="XM_003025075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V4"/>
    <dbReference type="GeneID" id="9580613"/>
    <dbReference type="KEGG" id="tve:TRV_00700"/>
    <dbReference type="HOGENOM" id="CLU_093235_0_0_1"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22942" checksum="049B84D2F09BDE9B" modified="2010-05-18" version="1">MDNGHFLDDILGLEDEFYAEGYRLGTLDGTKAGFNEGSVFAIEKTFEKFQVIGKLYGKGIIWAKRLPNQPEIVKSSTVQPPHTGSDETRDSVLLSGDAKLGELEAHPIPAQDLPALPSNPRLEKHIATFLSLVNPLTLSMENNEEAVADFDNRLKRAAAKARIIERMLGEPSEHTAERSAGASNIEDINSLPVHLTGSQQTRNSAPVVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D103</accession>
    <name>D4D103_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025091.1">
        <property type="nucleotide sequence ID" value="XM_003025045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D103"/>
    <dbReference type="GeneID" id="9580583"/>
    <dbReference type="KEGG" id="tve:TRV_00749"/>
    <dbReference type="HOGENOM" id="CLU_033465_0_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="320" mass="35931" checksum="1FDB5F020AAE1F03" modified="2010-05-18" version="1">MSSKEDTLRELYHYLPSKPAAIIFAILYIASSFLHEYQYKATRPQKFTMPFVLGTTFSSIGFVTRSLSALKIGDPRTLWRISTMFTIGAGPTYAGADYFVCGRIFSYVRYAAPISPLRTVRTFIFFDFLAEIGVWVGAGINDSKDPNSARAKLGVNLVRAAVIIQLALFACFVAVVLLFQIRATSRGFWRASHQQSGGTPGWVKVIYTLSTEAPFLCLEALVMFINAAMFNVIHPGVLLPSNPHVYLLADGMEAEDDSPEGTLEDTRPLKMKILDPLDIKGLFRKKQQLKPYQQRPLGGDDENMSESMIMLENRQREEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D163</accession>
    <name>D4D163_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4E-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025006.1">
        <property type="nucleotide sequence ID" value="XM_003024960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D163"/>
    <dbReference type="GeneID" id="9580498"/>
    <dbReference type="KEGG" id="tve:TRV_00811"/>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27475" checksum="BEABA1AC9D8E7078" modified="2010-05-18" version="1">MAAENGTKPEQAVNNENSTPDGTEAQNKDEQITVFHDPINFNVKHPLMNEWTLWFTKPPSGKGDNWNDLLKEVVTFNSVEEFWGIYNNIAPTSQLSFKSDYHLFKKGVRPEWEDQQNKHGGKWSYSFKFTKDRNQVPIDELWLHAQLTVIGDTLENDGDNEVMGVVVNVRKSFYRIGLWTRTIGRASNERSQDQAQKILLAIGRRFKEVLKLKDNELLEFSGHTESANAGSTRAKAKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1G6</accession>
    <name>D4D1G6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain protein (Adg3)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024911.1">
        <property type="nucleotide sequence ID" value="XM_003024865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1G6"/>
    <dbReference type="GeneID" id="9580402"/>
    <dbReference type="KEGG" id="tve:TRV_00916"/>
    <dbReference type="HOGENOM" id="CLU_026108_1_1_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055161" description="SUN domain protein (Adg3)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="51128" checksum="2FE2AC2B2688F9D9" modified="2010-05-18" version="1">MLRIPIWASAVLFFLAGPSQAGHADFHSYTSGFSRHHGGGHQRFHRSVPALEAHGVSYIEKRGGQCQFPADAGLVAVTPNAMNAGWAMSPDQPCKPDSYCPYACPSGQVMAQWDPKATAYTYPASMNGGLYCDKNGKISKPFPEKPYCVDASGPVKVKNSCGGVVSFCQTVLPGNEAMLIPTSVQDTADLAVPDPSYWCSTAAHYYINPPGTDTDTACVWGTNANPWGNWSPYVSGANTDHSGQTFLKLGWNPIYLETATPFRDESPKFGVKVECEGCNGLPCEIDPAKNKVNEITGSGTDGAGGAAFCVVTVPKGTQATIVVFEGGNSGGSGDYGHGDKDEKPKDDDKKEPKPSSSSSSPAPSSTPSSSSSTQSPTPTSTSASSSSESTPTPTSSYPSKSSSTTSSSATAAYSTTSKSPDAYIPSPHVFIESPSSSVHHPTNGSSIIMPTPTNSEKAPAPTHNNAASAAAISVMSLTLSFLIVTIFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D210</accession>
    <name>D4D210_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024705.1">
        <property type="nucleotide sequence ID" value="XM_003024659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D210"/>
    <dbReference type="GeneID" id="9582880"/>
    <dbReference type="KEGG" id="tve:TRV_01112"/>
    <dbReference type="HOGENOM" id="CLU_045192_0_1_1"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055515" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="29094" checksum="D5D6200B91E05DA6" modified="2010-05-18" version="1">MQLRVALCLLPLAVRAANIVSSNDDGWAEVNLHTLYNALTNSGHSVVVSAPADNKSGTGSSDANPTPRNTPCEFDSCPAGSPAVGYDQNNPRFNYVNSFPVTSMRYGIQNVAPRFFGGRPDLAVAGPNVGANLGRTVQISGTVGAATEAALEGVPAIAFSGSVGHLTAYWDYTPNYSEVYATLAAQVTNALLQNAKPILPPGIFLNVNFGAVSDYDCTSPDDFSFVLTRILPTSGNPDVNICGNGGRLPTESDIVKSDGCYVSISVATARGKRDADSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2I5</accession>
    <name>D4D2I5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS sugar permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024578.1">
        <property type="nucleotide sequence ID" value="XM_003024532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2I5"/>
    <dbReference type="GeneID" id="9579902"/>
    <dbReference type="KEGG" id="tve:TRV_01290"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="524" mass="57214" checksum="AC0A3D58A4B7295E" modified="2010-05-18" version="1">MATDDSNKNLRQSPMECLRDLFNWKVRVEETDPVTGVTTVEYRDPEPLKNPFAMAAQLSASNWLFFLAGLFAWICDAFDFHALSIQTVKLSKYFHRSKTSISTAITLTLLLRSVGAAVFGLAGDRWGRKWPMVANMLILGALQIATIYCATFSQFLAVRSLFGLFMGGVYGNAIAMALENCPVEARGLMSGILQQGYSMGYVFAACANLGVGGGTDSWKVVFWIGAGISCLSGVIRIFLPESKQFLAARKERKEGKKSGASPGKFWRDTKEMLAKDWKLVIYCIFLMTWFNFYSHTSQDSYTTFMLTQKALNNSAASRASILMKAGACVGGTIIGYMSQWFGRRRSMVLSALISGILIPAWILPHGERSLSASGFMMQFFVQGAWGVIPIHLNELSPPAYRSSFPGLTYQLGNMISSPSAQIVNAVAESVSVRGDNGKPAPAYGATMGVATAIIALGIMVTTAFGPEMRGRKFELAKVAGHLHDGEQEHAGKEDLESGMVGRSHDEKRSEEAEVSESEKAVDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D358</accession>
    <name>D4D358_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024317.1">
        <property type="nucleotide sequence ID" value="XM_003024271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D358"/>
    <dbReference type="GeneID" id="9579425"/>
    <dbReference type="KEGG" id="tve:TRV_01515"/>
    <dbReference type="HOGENOM" id="CLU_028760_2_0_1"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="339" mass="38042" checksum="CEB01B00C1636344" modified="2010-05-18" version="1">MVLWLDEIEKKKKMLMGASVAISANFWLVGEDKELSPKKYFIIIPAMFGNGQSSSPSNTDLSPFPAVAVYDNVRAQYKLVTEHLGVKHLRAVLGWSMGAGQTFQWAAQYPDFMDIIVPFCGSAKTSLHNQVFLEGVKCALLSAKRFRSAGSGKDGICSEGIVGRKWAEEERDIGLRAVGRVYAGWGMSQPFYREKLYETVLGYKDLEDFLVNFWEKYFLSKDPENLLIMLQTWQNADISQQEPYNGNFEAALKGIKAKALVLPCKHDLYFPPEDSEYEVANMAPGVGELDVFPSIWGHWAGGPGENKEDVKWLNDKLVDFFKRTPISDSLTAALKDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C4</accession>
    <name>D4D3C4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024233.1">
        <property type="nucleotide sequence ID" value="XM_003024187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C4"/>
    <dbReference type="GeneID" id="9579271"/>
    <dbReference type="KEGG" id="tve:TRV_01583"/>
    <dbReference type="HOGENOM" id="CLU_052067_0_0_1"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1746" evidence="2">
        <location>
            <begin position="118"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="34514" checksum="E431B273FA233CE3" modified="2010-05-18" version="1">MRETAKTNETDVLRLKLANTNAAFCDGIPPLFPSLTRNISMTTQAPITDAEYITDVLNIPSIPGSEDAESNASGTGQPDLGSRRVTFAKSKSLFLDRLTRDFDLLIYCELSALYYMDNLVCIFLHIASANPSAGEASRGYLHGGLFIDFVGQKGPTSKLQLLAVDLLVICLQILMVGAILEKEKVSALTSSRRTAETIPSSTVPEQDHDSEEQGLLRSSQNLSNQEDVMGNRQVSGIELSDLGGERGVNAVVGMHPRDYFHSGEALIMNLNIGRTLRQQWQNRTAAIAPPHASLSGTRVPASTFIRRQLGIQAEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C5</accession>
    <name>D4D3C5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024234.1">
        <property type="nucleotide sequence ID" value="XM_003024188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C5"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="GeneID" id="9579272"/>
    <dbReference type="KEGG" id="tve:TRV_01584"/>
    <dbReference type="HOGENOM" id="CLU_058707_7_1_1"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="14035" checksum="19178572BC900092" modified="2010-05-18" version="1">MTYIQSPVSTICVGQAASMGSLLLCGGEAGKRYCLPHSSVMIHQPSGGYFGQATDIAIHAKEILRVRHQLNQIYKRHLTGKEMTLEEIEKLMERDYFMGAKEALEMGIVDSILDRRMPSKEESTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J1</accession>
    <name>D4D3J1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024218.1">
        <property type="nucleotide sequence ID" value="XM_003024172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J1"/>
    <dbReference type="MEROPS" id="C19.092"/>
    <dbReference type="GeneID" id="9579256"/>
    <dbReference type="KEGG" id="tve:TRV_01651"/>
    <dbReference type="HOGENOM" id="CLU_008279_0_0_1"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="60"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="744"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="876" mass="96714" checksum="26647CFC5185AA23" modified="2010-05-18" version="1" fragment="single">ANSTSANGTAASKKDSAPLPKTPLQKLLSDAGPLKSDGSDKFFGMENSGTFSSLWDIIMSFLTGLTSHSYCNSILQCLYYSAPFRESVINYPQRSPPESLKHALSTNFKYPDPDISLEEALLQTKLKQQQLATSNGVRPTLNPQNQIPKAEDKDSPEYKKKVAMHTLPVLETTDNSQNYGMQESLFTSLKDIFESIAASEERVGVVRPQHFLDVLRRENEMFRTAMHQDAHEFLNLLLNEVVNNVEAEANRTSMLEADADSESSTATSTSVATTLATSVGGSAKSPYSTRWVHELFEGKLTSETECLTCEKKSQRDEAFLDLSVDLEQHSSVTSCLRKFSQEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDQQRLQKLFHRVVYPYYLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTEDRGWLLFDDEMVEPVDKSYVRNFFGDKPGQACAYVLFYQETTFEAMQRELQSDERMSAASKSQDADLAPLAALDLKTTGNQPIPTPPQDISRVRSAIPQLPTTTDNSTAGSYNPIKLIPSAPQLSNIGDAPPTALPTTAANSQPATAPTPSYNKLPISLPRIPLMSRTPDRAAEIQSKKERAREEKDRKAQEKETQKQKRKEQEKAEARLRELAKKEEQQIKSALDASKLTAKEEKKRLSSEKKRLSSEGASDSANGNGSTNANGNGNTNGIANGFTNGINGIAGGLGRLKLGSRTLSYSRKHKDNKDNKDKVPALPTASASAMNGNPTASDITITPKNFQPRELDTSSSAINDAANQPPASGSASGSGTGEQPHLASRVLAQAEQEDFSSQQQQSQITSLPQPPPTPSPPKQPTPRRSRFSLRKKSFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3J3</accession>
    <name>D4D3J3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024154.1">
        <property type="nucleotide sequence ID" value="XM_003024108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3J3"/>
    <dbReference type="GeneID" id="9577151"/>
    <dbReference type="KEGG" id="tve:TRV_01653"/>
    <dbReference type="HOGENOM" id="CLU_023210_2_1_1"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="452" mass="50851" checksum="1E755B9736976EC2" modified="2010-05-18" version="1">MRSANRTGFVETVLSEAIPMTGRMIHGRNSAGSLWEASQDYDVHGRYINSIDRGKLNTTLLDELEKEPNVKIFFNHKLTGADFKNKKAWFERKNPGDTPGFRSTSNGDDKSINLTRAPELEVPFDLLIGADGAHSAARYHLMKYTRMDYQQEYIDCLWCEFSIAPSENNDFQISPHHLHIWPGGDFMFIALPSPDKTFVCTLFAPAEHFATLESDPKILLKFFQTHFPGVSPELIPPEDLIKQFNTNPHLPLISLKSSPHHYGSSAVILGDAAHAVVPFYGQGLNAGLEDVRVLFEHLDKQGVYSASNADNSQRIASLRAKALDAYSLQRIPDAHAINHLSRENFIEMRAGVKSPVYRMRKALEEALYKYLSGLGWSTQYARVSFSNDRYSEVVKATKRQTNVLSKAMLTTFVSLVGFSTIGLWKWPWSRDIITRMLHATTRIAKGIEGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3N0</accession>
    <name>D4D3N0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024191.1">
        <property type="nucleotide sequence ID" value="XM_003024145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3N0"/>
    <dbReference type="GeneID" id="9579229"/>
    <dbReference type="KEGG" id="tve:TRV_01690"/>
    <dbReference type="HOGENOM" id="CLU_1144970_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="243" mass="28189" checksum="1F71F9919AEA6855" modified="2010-05-18" version="1" fragment="single">GGRGRGGERERGREEERKREEEKGGGRLAFFLFLRGGKLKKTRARQARETTNGRRTSLISLLLQAGWETNEREEERREREREREGEEGEGREIKELSLLGDEKKKKKKKKRRERRRRGRRRDEEDAAKRAMDGGAGFAQRAEGATDWTRGDKGRQGDLLPLAYTLTMQALLFFLKAEGEAAKRQTPRGWWWQAEKDDRDRKLKKKKEMMIEQTEGAGFAGLPACIYVFLLAVSPFFPPDEYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3V8</accession>
    <name>D4D3V8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000094">
        <property type="protein sequence ID" value="EFE43454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024072.1">
        <property type="nucleotide sequence ID" value="XM_003024026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3V8"/>
    <dbReference type="GeneID" id="9582775"/>
    <dbReference type="KEGG" id="tve:TRV_01771"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="413" mass="45125" checksum="C4FA39AAB8AD2424" modified="2010-05-18" version="1" fragment="single">ISYAVESRKPFVVRGGGHSNGFSTISSPGIVLDLSQMRNVSIDIEKKVAIVQGGATMGDGLRAAASEGLAIATGTCNEVGLVGAALGGGIGRLLGHYGYAADTVVSMRVAVVGSSGRARIVEASREINPDLFWALRGSGHLFGVVVEATFRVFPWQHETWHSCLAFRPCDAGRVAEAVDRVSYRGGMQGRLVFCAPNKQPIVLLQLWYLGNPEEAAEKFEPLLGLPFMADHPLHSIGRLIPYVNLNDSSERICSYVGRKNLAAFGMRSISEASCMAALMVYMDFITQYPEALRTHILTEFYSMDVVSELDQDGEETSIPGKMRRAVKYWVMPLAWYEDAALDDACAGLNGAVRDAFLTNTDGSRAESIAYINMPFEREDASDIFGDKQHLERLRSLKQKWDPLNIIRGTVGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D455</accession>
    <name>D4D455_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000099">
        <property type="protein sequence ID" value="EFE43359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023977.1">
        <property type="nucleotide sequence ID" value="XM_003023931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D455"/>
    <dbReference type="GeneID" id="9582679"/>
    <dbReference type="KEGG" id="tve:TRV_01869"/>
    <dbReference type="HOGENOM" id="CLU_057784_2_0_1"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="179" mass="20765" checksum="AC6DC7FB5CA42EE9" modified="2010-05-18" version="1">MRSILTVSLHSLDLFWNFTGSPYNTIFKILFISSSAYTIYLMLNDYKPTNDPNIDTFKVVYLLGASAVLGVLFPYKYTASEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGIYRALYIPNWIYRYFSDGYFDPIAVVAGIIQTILYADFFWIYFQKLVSLSLMIQLIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I4</accession>
    <name>D4D4I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023804.1">
        <property type="nucleotide sequence ID" value="XM_003023758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I4"/>
    <dbReference type="GeneID" id="9582377"/>
    <dbReference type="KEGG" id="tve:TRV_02001"/>
    <dbReference type="HOGENOM" id="CLU_011276_2_2_1"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="522" mass="56341" checksum="395E975D0E49AE7B" modified="2010-05-18" version="1">MTGSPAGSGRRIPLLAAIDSGSHIHLIIGSNPLAAARITKSIDSGATPILISPPENKLPSTLSERIEAGQVQWIQRGFQDSDLLTFGREEVEGVVDAVFITLDKTYPLRKGGSLASRIRREIASFLPPGLGTAVENLGLLRKRIWEEDAIEEEADKDSFEDDSDDSTAQKHTFNTLVVDAAATSKTRRIRWLSQICEYWPLRQLASVTLPGVEKMLEAYGVGKNPLTNGKSIGPEAKKGKIILAGSGPGHPDLLTRATYHAIKTADLILSDKLVPAAVLDLIPRRTEVHIARKFPGNADKAQEELLELASEGLSAGRIVLRLKQGDPYLYGRGAEEFSYFRAKGYEPIVLPGITSALSAPLFADIPPTHRGVADQVLICTGTGRHGVAPSPPNYIPSQTVVFLMALHRLASLIESMTTYTGDSKDDVTPSRSLWPKDTPCAVIERASCADQRVIRSTLEHVCLAVQEEGSRPPGLLVVGTSCEVLHQPGRKWIVEDGFKTLDGLNKDLNLNAIAALGGIDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4M8</accession>
    <name>D4D4M8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023848.1">
        <property type="nucleotide sequence ID" value="XM_003023802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4M8"/>
    <dbReference type="GeneID" id="9582460"/>
    <dbReference type="KEGG" id="tve:TRV_02045"/>
    <dbReference type="HOGENOM" id="CLU_879901_0_0_1"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="320" mass="34413" checksum="FE7F25FAC59B2DE2" modified="2010-05-18" version="1">MELPLSSTSGVDGVAGDREKHEKITCYSYDSKREYPNYVKCPDSDSCCETIEQCRPDRLCTSKEDPKTLIRPPCAYKPWTNSCAQVCLYDNKDSPVLPRAVVCEQTGPSSGSYCCDDNRTCCIDRAGFFLDENGLLIGRANETDNSTLSPKPIGVSVTALRSMGSASATSTPAHSPIKDKTGLSTVDKAGIGVGVGVAVLLAIIAGTLLFLRSQRRKRRTRADSASTGGNNSTGPGTADTDAPTDTWGDDKEPLPGDEQRREKEEERAYELMGDGGTPELESVESPRHEAPPSELPVVGVQQTEPIELPADQPTGKPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q7</accession>
    <name>D4D4Q7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023784.1">
        <property type="nucleotide sequence ID" value="XM_003023738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q7"/>
    <dbReference type="GeneID" id="9582357"/>
    <dbReference type="KEGG" id="tve:TRV_02073"/>
    <dbReference type="HOGENOM" id="CLU_064135_1_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7735" evidence="2">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="24342" checksum="E6C23BE09C3F38B8" modified="2010-05-18" version="1">METSVQQAHLPDHTAPYSHSFILTQIHILISNMRVTFLFVAAASAASATVSVSVSDMTDTTLLSTAPPAGTTSGPSYCTASDLSQYSSLPKLTGSLLDEFYSFHSELQQDCTATESGIGAQSCSVLESSYWCSFSTAVPSTLLSDYSSYASSAEAKRQADADRTTMTTTTMAAGTPGATTGQTITVPSRSGSTTGGPKATKATAKPNGALGHRGMTGIWMVVSMGMATALVNMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4U0</accession>
    <name>D4D4U0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023720.1">
        <property type="nucleotide sequence ID" value="XM_003023674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4U0"/>
    <dbReference type="GeneID" id="9582288"/>
    <dbReference type="KEGG" id="tve:TRV_02107"/>
    <dbReference type="HOGENOM" id="CLU_021768_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="305" mass="34849" checksum="CFA5D58EC816F862" modified="2010-05-18" version="1">MSSRALPSAESATFLESSYFSRNGAEAALPSPANVREQSVLQGPASQAKRDYGFKPVRYEHLGLIVKYGRAPEVTVAEGQLLWALRRTLPTVPVPEVYGWTHDNGQVFIYMELIKGVTLEQRWGFLGPAERVAICEQLREIILDYRRLQHAPGDFFLGHVNREPLGDIIFTSGNLPPAGPFYSVTELHDWISTVLKMKVQPYHWQGKELSEIPDPYRSRLPDDAKVVFTHGDLHPSNIMVSEVTNKIIAVIDWRQSGWYPDYWEYCKADYTAEINGEWATTYIPIFLKEPECLDAWDFYPRSFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4W6</accession>
    <name>D4D4W6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">TRV_02133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023746.1">
        <property type="nucleotide sequence ID" value="XM_003023700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4W6"/>
    <dbReference type="GeneID" id="9582281"/>
    <dbReference type="KEGG" id="tve:TRV_02133"/>
    <dbReference type="HOGENOM" id="CLU_026794_0_0_1"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="443" mass="48848" checksum="44D0D94C807040CE" modified="2010-05-18" version="1">MSIDINWEAATSGPDGEELAERIRCFIHDKFQQIALPRFIRSVEVNSFDFGTVSPELQVRDICDPFNDFYEEDEDGADLSDSSEGDEPVPSSMSLSQSTLKGDAGSPGSSNDDGSGNSNGRSGYFQRRRGSREYSGEIPQPLMSPINLGESFNPYLFPRTGTPGIPGGTSHIGYYNMPRGGLSGTQTPLASVASVARGGPLSLAEGWPPPARQRERARSSDTDVDSPQSRSRPSTSSTRQVTPVEGGTPRDPAEIPESESIITGHLDSALPARRMREQKPDDFQVLCRLQYSGNMRLSITAQILLDYPMPSFVGLPLKLNITGFTFDGVAVVAYIRKRIHVCFLSPEDADTLLGADDKMTTTEDYHEHHGHHSHHSGSANTTGSRRSNESLLREIRVESEIGRKESGKQVLKNVGKVEKFVLEQVRRIFEEEFVYPSFWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5B0</accession>
    <name>D4D5B0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023533.1">
        <property type="nucleotide sequence ID" value="XM_003023487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5B0"/>
    <dbReference type="GeneID" id="9577005"/>
    <dbReference type="KEGG" id="tve:TRV_02280"/>
    <dbReference type="HOGENOM" id="CLU_049078_2_0_1"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50542" checksum="BF0F8B1801E9898C" modified="2010-05-18" version="1">MFDTCLTLHRVAEVEVVEVVEVAFRVTTGWIRTSPVWASRSVRRLLSFFKLQPKTIAWSKLTKEPCFYSPTLSGKSVLPEMENYSLLDQADEAITDGLHKSRLLNVEEKPFKRITKRLLAPNSLISSPGSFLATPPPEATPGNADAIQEHEAEKQKMLEKWRQLREDITLDFTAFESSLVRIQLLLASNEKERERYAAEKLEIMATAQEVRDNTTELRLQLEEAQNTLALRKTYDELADKITSNRLLRPRDDQQANLEKLHAEIAKLEKESSEYAQTWAERREQFGRIVDEGMHLRRLIRDEKEEVERREGMEEDDDGDEGDASSKGKRSAASTPRPDPENSVTPSQQTGTGIGAGGEETNPVVAKLQAEKSGPATRGGTPLRQTITASETSTPEEKRISKDDGDENMVDEGEISGDEGGAQEGTTSQAMEDDFEGEEIPDSRSTEKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5F2</accession>
    <name>D4D5F2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023575.1">
        <property type="nucleotide sequence ID" value="XM_003023529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5F2"/>
    <dbReference type="GeneID" id="9577047"/>
    <dbReference type="KEGG" id="tve:TRV_02322"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64147" checksum="06226E75336C7DDE" modified="2010-05-18" version="1">MGNSQGKLSSPDHPVNLNQFRLLRVVGKGAFGKVRIVERKDTGLTFALKYIRKDEDGVSIISMIIVILTISRYIVVDLMNGGDLRFHISRKCFTEEAIRFWMAELACALHYIHGQGIVHRDVKPDNILLDSEGHVHLADFNVASDFKPSKPLTSRSGTMAYLAPEVFQGGGYLSNVDWWSLGVTFYECIYSKRPFDGRSHSSLSEAIMRTQPKYYVTNPAVTVPCLHALSALLEKDPTKRIGAMNFESFTTHAFFAPIDFDALQRKEIEPVFVPSSDKTNFDATYDLEELLLEEAPLEARARRQKPRAELKDDATAKEIREDELHRIIETMFEPFDYTTMNYETTAAAAIAASANPEDCLNLTTSPSQRRRHRHTNSQGRSGSSSPSVRTDRSTRTDKSTRTEKSYRSTASDAHGQNNVPVDSVNPGSPSSDRGGALSRSPPTQPPPGPPSLPSQRHANRSHTIASTNQGVPQFSPPPPPPAQLSQPQPRGATRNRSKSGGVQMVLEETGSWSGLADQTTNGDALPNNVNGNSLPNGTGSTTGAYGNTSGGMFSFFSRKKGRERSPKPSERGVLGKEGARVVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5F7</accession>
    <name>D4D5F7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023580.1">
        <property type="nucleotide sequence ID" value="XM_003023534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5F7"/>
    <dbReference type="GeneID" id="9577052"/>
    <dbReference type="KEGG" id="tve:TRV_02327"/>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="35010" checksum="24C8E4A35332E29B" modified="2010-05-18" version="1">MASGIPEADLLSFREHLKKSKRILALVGAGLSAASGLPTFRGVGGLWRSHRAPDLATPEAFGVDPGLVWQFYSYRRHMSLVAHPNRGHYALAALARKIPQFWTLTQNVDGLSERADHPESQLHRLHGSLFTVKCASEYCTYSRDNDFQDPLVPCLAIPKAGPQLNPSTDDKTGEQAAKAIHAALDEKISPSRGEDLDISDANVPIPSLTEDDLPHCPKCSTGLLRPGVVWFGEELPNDTLDSIDKFLNEGPVDLVLVIGTSAQVFPAALYIEEGRDRGARVAVINMDATHLPNGGLEPTDWLFQGDSSVILPEILKEVIGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M8</accession>
    <name>D4D5M8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023464.1">
        <property type="nucleotide sequence ID" value="XM_003023418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M8"/>
    <dbReference type="GeneID" id="9583482"/>
    <dbReference type="KEGG" id="tve:TRV_02401"/>
    <dbReference type="HOGENOM" id="CLU_828937_0_0_1"/>
    <dbReference type="OrthoDB" id="4316405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056002" evidence="1">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="37470" checksum="6F05AD1E4B4A0E88" modified="2010-05-18" version="1">MRGILITFLLTWLLSLSSYATGDKPKITDSQVAHVFERIWLWEMYDFICDLESPVKQGKIFPHDKTYNDWKLNIGKKRKDKRLTYAEFQKRLQGGNPHDGTLPTIDSPADGDPFKSAKQLLDLRWHGEFAPHEVDPSLPKPKKPDLEGLNTKNYLALVGKIEKEYSKFRIGLVKHPFGNVDDPVRIQRIATTTKAIQTFRYQSRVQYVAGSVTSTDEGGLGLAKVKTDKHPTALTYNGTPLGPADYEKTNYVETYKANCIGEDETRPGPELKALGVKSKKDFTEIMSDFGRDYDEYSSRSDKNHLLVLKRWTQVNDKAHKSAEELKQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z1</accession>
    <name>D4D5Z1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear protein SDK3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023412.1">
        <property type="nucleotide sequence ID" value="XM_003023366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z1"/>
    <dbReference type="GeneID" id="9583432"/>
    <dbReference type="KEGG" id="tve:TRV_02514"/>
    <dbReference type="HOGENOM" id="CLU_049352_2_0_1"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="44145" checksum="66CA5890F7240869" modified="2010-05-18" version="1">MAESSIASAVALPEPPQYPGPEALSKRRQSISSNSSSKRRRLSADEFSERANQSSPPSCSNTQRLNGSSDVKAADKPKPGRDEERKRGRRLFGALLGTLSQSSSTPAQRKRSEIDKKQQAKLELQDKEYNELTKKKYEDLMASRRKDQALYDSQSAEIRHSNKLAMAHFLRTKAEPPLYYRPWYLRPQDETKIQSQIAEAKSSIEKEIMDSSSHYKQHESTIHKREITVDNPDDNSAEDKATKDTTDLIGSNTNDPLEQTSEAPQRTLIDTNLVPVPPATQGPSGLDEEHPGEVLMENTEDADIPPYVLVFFILSGCFSLPPTSIFRSTFNIFQSIISIVLGEIMVAIHTAHLRQSRMCNPMSQQVHISKSNPSRTVLESGVQLTSSKQSDPVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D680</accession>
    <name>D4D680_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023269.1">
        <property type="nucleotide sequence ID" value="XM_003023223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D680"/>
    <dbReference type="GeneID" id="9583277"/>
    <dbReference type="KEGG" id="tve:TRV_02603"/>
    <dbReference type="HOGENOM" id="CLU_085403_0_0_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23138" checksum="7F66301CD5FA1FF1" modified="2010-05-18" version="1">MAKFEAALKKIDDIHSEDPKLARVKTDAGEDEEIPDELHYANRMTEYLLQHDPNPSELLRLAVRAQHLQRWEIPRADYPMNRMGYLFWRTAQKKRQATHAEEICLSCGYSTEDAARVAALVRKEDMKRDAECQVLEDVACLVFLADQFEKFEQEHGEDREKIVNILRKTWAKMSERGHELALQIKMSNQAKGLVAEALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6G9</accession>
    <name>D4D6G9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023172.1">
        <property type="nucleotide sequence ID" value="XM_003023126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6G9"/>
    <dbReference type="GeneID" id="9583192"/>
    <dbReference type="KEGG" id="tve:TRV_02694"/>
    <dbReference type="HOGENOM" id="CLU_084528_0_1_1"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="232" mass="26680" checksum="0E2C4BA0ACBBA262" modified="2010-05-18" version="1">MGREEQAEEKETLQSIFPDELTEISDNSYRISIRLDVTSQDGEEAEPPTLILQVTYPEDYPDVAPRLELSTPPNAPKYPHLDIQEDRDRLLESLQSTIEENLGIAMVFSLVDSLKEGAELLISERQTAIQALKDMEAAKAEEEENRKFQGTRVTRETFLEWREKFMAEMKEAEERRQEEKEAEEKKKKGANKEPKKLTGRQLWERGMAGKGDYEDDMDDSIPEKLGKVELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6H2</accession>
    <name>D4D6H2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein (Rad1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023175.1">
        <property type="nucleotide sequence ID" value="XM_003023129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6H2"/>
    <dbReference type="GeneID" id="9583195"/>
    <dbReference type="KEGG" id="tve:TRV_02697"/>
    <dbReference type="HOGENOM" id="CLU_042937_1_1_1"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="215" mass="24995" checksum="64026121CCDE72BA" modified="2010-05-18" version="1">MKSCGKGDATSIERVDSLIAGTEPFLERYKQKCARLAREREEKELEDARKKQNKRRFSAKRVLESVLARPYPTVSGIRRVPRFACARGIPFLRIKKPQPKNLSVAIQIRQDARWKNILRRQELGVDSLFAKDEDLWDQITSRTETDSWDKAIQQNINRVVETIKNGDERDLELARKMWNVVVAERRLAEKEARQREKMGQADETKTGSSESTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6P0</accession>
    <name>D4D6P0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023077.1">
        <property type="nucleotide sequence ID" value="XM_003023031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6P0"/>
    <dbReference type="GeneID" id="9583097"/>
    <dbReference type="KEGG" id="tve:TRV_02767"/>
    <dbReference type="HOGENOM" id="CLU_009290_0_0_1"/>
    <dbReference type="OrthoDB" id="5354164at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116081" checksum="8FE98EAAA6A18045" modified="2010-05-18" version="1">MSLLSSFKGSILSATNENTACLANLKFDFSLVKVEAPLEFQPLGSALTFRRRDEAEYGPQHQTARRLAALFEPLIPSTPKLISAYGTRVSEIIESPGVNPTGSRAHGPFKEYVGADGTAVWAAATSGVAALGIYLLSCLLARAWDSGKAIAIWVELIEERKREIQSAFERNVPISTASAMSSLQPIARHDIALWDASSRSWLRSADQAKQRDHDQLLLISKNVRMPFVGGSSTYEQVVSTWKRAMLAVEDLLCGRPQSILDAGVVLAMSSWHLYPDMIVLRNETVNVKFKDPLFPSTGVCTIGLEGSDDEGAEGVRWSLALSHLQYYGSAVKVTGPRDNSRVTISQLCIVAFGGLLGHWGVGSKDIEDTIQLFCCIGDILNSSASEEQPELHIQKPERWINPIIHACRKLSSSKGEEKEENTRLLRYGQRRATKFLRRDEDKIPPYFGLCNQLLLSALSGDDCDLTYLRGLAQSMGYASSDCLIVQAHWIGRGWKSGKPHYFEYATATPLWIKATGKRGSEGEEIYHEMHAKWYSICSDSSGSTEKVEKEINSRVKRINLDPTTNERCFFTKHGQTASDSELLSVKWHNPPPLFRCREGQEPARGPAAISDMACLVADEPASTCNCFELELPNTFVSTAGKAYSGFINVYGSRRFALFVRDTPNSRSQHDKFVKCGAISPKQAVQQLCRHPIQLTKMNEYLNMTHPKKPVTGTDLFILRNSRIVSSHTSAALHSLYLATLIYSKLEGLTVLLRIASQPLCDASWVLDASSSAMRSKARKTHPQAPSRQEAFACIAHFDSGQANIRPSDLDSTLAICNQNSIFVAAVVLSDPLEKVEDYEIRRLVGNIGKRGISMLVAPHNPQIREPKDDYCIVNHAPYDGKRENNFNDTSLHLSFTEWTLPLATADSQTIDQDVFLVESVISVRDRGEWVADLDILGIKSRMLFGNGFDCPSLEDDEDDENAMLMYGYTSIDSWEELLDPPLGVGIFRAQGNWVARLAAVSILMQRKKGIDMAVFGKNLSLRSFEARLQFDVEARGAKPPESFICID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6P3</accession>
    <name>D4D6P3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023080.1">
        <property type="nucleotide sequence ID" value="XM_003023034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6P3"/>
    <dbReference type="GeneID" id="9583100"/>
    <dbReference type="KEGG" id="tve:TRV_02770"/>
    <dbReference type="HOGENOM" id="CLU_007199_0_0_1"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="839"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="898"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="927" mass="102053" checksum="CB74950E74A32B72" modified="2010-05-18" version="1">MPPPKSKAESQLQKEKLVNSYHELLNEFSSKELRNVGNYALGKLIGKGSFGKVYLATHKLTNGSKVVLKSSSREDPNLAREIHHHRQFHHPHIARLYEVIVTEKLVWLVLEYCPGDELYNHLLQNGPMPIEKTQKIFTQLVGAVAYVHSKSCVHRDLKLENILLDKHENVKLCDFGFTREYDGKASYLQTFCGTICYSAPEMLKGEKYAGEKVDVWSLGIILYALIAGELPWDDDDDQVTKSRILTEEPKYTDRFPDDAKSLINLLLSKRPLLRPTLSDVLAHPFLAEFAPQQQANLKLTRPPPFSTPLEKATLERMRSAGVNTEQVMQNVLAQRCDALAGWWTLLIEKEERKERRRERKRREKEAEAKNLRRLSAASSRLERISAALVEVDEEGHPEDPRSRGRRERRSLTSQQLNVPDLPKLPETAPSSDGLLTPPLPPPPPVEKDFPRPPRSTSRGRPVPPPKERRISKGSNYHLSASQPDLTRPQGILRRQGARRRQYPIISQLAQLKHWIIESTKRAKSPHPKAFSSSTRKFLSNHSSPPKKGDTPNKDAAVTPTSPNFPQNQQTPTAKRSSNASSLALSNASYPGARRTSSHTQRPLNTSSSHNRNSLSPSPLTPRNSYRRSSAGLRGRKSTSSSVSSIRTVHHAHSHSKTSSISSNSIDTVSTPTGPSAKALGRSPHSSIKILPATPTSMSVFPSNIRLVRGGPNNSLTSAFNEAAPALIPSPSSGPIFARRKRATFKGPTLSSTHMLSGAGPGTPSLMRSRASSVASGEIMMAGARKSQIIEEEEDEVLPDDTTEEVDCFSPTDERGPGFPESSSLDAKYANAIAAAATMDPANLRSGSERDGSPDSRQLLPAAEITELPSFSKIPSTEHDRSPLRPPRSSSLREAKNGSPGSLNASDSLDNIAETSPTLKKTSTATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D7</accession>
    <name>D4D7D7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022857.1">
        <property type="nucleotide sequence ID" value="XM_003022811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D7"/>
    <dbReference type="GeneID" id="9581581"/>
    <dbReference type="KEGG" id="tve:TRV_03019"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="374" mass="42686" checksum="A50E395DF428FD52" modified="2010-05-18" version="1">MPGLPTSIDLDECIERIYKRELLADSVIEAICSKAKELLMKESNVVHIAAPVTVVGDIHGQFYDLIEIFKIGGFCPNTNYLFLGDYVDRGLFSVETISLLICLKLRYPERVHLIRGNHESRGVTQSYGFYTECARKYGNANVWHYFTDMFDFLTLSVVINNQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDTERDEFSLSPRGAGYTFGAQVVKKFLEVNSMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNLASVLEVSDTGERFFNIFDAAPENNDVHRGDQATQQGKDGQNPSRKKKKKKKKAREIPHPIQPDELPRSFSLDRFLRGYFLQQSVISQSGTKADTEKKREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7I0</accession>
    <name>D4D7I0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022838.1">
        <property type="nucleotide sequence ID" value="XM_003022792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7I0"/>
    <dbReference type="GeneID" id="9581562"/>
    <dbReference type="KEGG" id="tve:TRV_03062"/>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="405" mass="45198" checksum="8EE6F36128D75732" modified="2010-05-18" version="1">MLQARRLGKELLVGVHSDEEISDNKGPTVMTLAERIAAVDACRWSTKSIPYAPYVTSLDWISHYGCQYVVHGDDITSDSDGNDCYRFVKEAGRFLVVKRTPGISTTDLVGRMLLCTKTHFIKSLLAYITGKEGSGTPEEMEEAGKSHFQRIRDYATDETGLRPGPEVWHWNGPSTLSSTPATGGAHEQLQQLVEGVKPKPGQKIVYVDGGFDLFSSGHIEFLRCVHSAEEKEGDARGWFHPDQVAQRVKEHGEDYGPAYIVAGVHDDEVINRWKGLNYPIMNIFERGLCVLQCRYINAVVFAAPFTPTEAYLSALPFGMADVVYHGPTTFIPLTFDPYEEPRKLGIFKEIGNHQFQNVNAGEIVQRIMTARAAFEERQRIKMLKSINEAEVKKQEEAAKLSGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7S3</accession>
    <name>D4D7S3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein (Pet8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022696.1">
        <property type="nucleotide sequence ID" value="XM_003022650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7S3"/>
    <dbReference type="GeneID" id="9581354"/>
    <dbReference type="KEGG" id="tve:TRV_03157"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="120"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="231"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="36175" checksum="2C25DEEE0F632BA7" modified="2010-05-18" version="1">MAGQKDESHATQSALWTRSLLAGAAAGLTVDVSLFPLDTIKTRLQQARHKTQGSSVARSLNGSANGLKVLRQTFRGIYAGLPSVLLGSAPSAASFFVVYDGVKRYFLPPTTSPSTVPWQHTFLTHSVASSLGEVAACAVRVPTEVIKQRAQAGLFGGSTLLALKDILSLRHGNGSQNGSLLVIRELYRGTSITIAREIPFTILQFTMWEGMKDAYASWKKEKNPGAKVIGISATSSAIFGSIAGAISAGLTTPLDVVKTRVMLARRGGNPESGMGKVRVRDIVKGIWRDEGASAFWKGIGPRVAWIGIGGAIFLGSYQRAWNLMEGHHTEQKLQSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D895</accession>
    <name>D4D895_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022532.1">
        <property type="nucleotide sequence ID" value="XM_003022486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D895"/>
    <dbReference type="GeneID" id="9581109"/>
    <dbReference type="KEGG" id="tve:TRV_03331"/>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="272"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="526"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="598" mass="67385" checksum="E0E2BAFB7DCAF621" modified="2010-05-18" version="1">MKRKQQEISSDEDPLQSELSNTPKRSKQTSRKDNELNGTPTKHSAPDTPSGRLRSRLTKQTPTKNVDFAPDLVSPLKTPTARALFKTPTKLKNVDNGTPNGTPSRIRNADRSAKRKSARVLLDPNEDDLWDGSNKLAREIWDVPSDDNAVPQVDTVAMGGTNRPKEPDSKPEHAAKEVPKEPPVTPRKRGRPPKVRGPEEQTPKTTKTPRTPRRNERVTTPDGDLPPQEKYFFQTRTGPVQTSNNTMAKSSLFTHEEFFEHLGKYKDPLQEEKDYLLELHGRSFPQWHFEMTEGFNVCIYGYGSKRKLVQRYADWLYEHCNQPPAIVVVNGYTPDITIRSILATVAMAILGPDDTSKLGVQPNDVLESIRAALLKNPPPQPITVLINSIDAPPLRRAQQQSHLARLAGIPHINILATTDTPNFLVLWDITLRDKFNFVFHDCTTFASYNVELNVVDEVHSLLGRKVRRVGGKQGIGFVLKSLPENTRKLYRLLITEILMMLGDNQDGEEEDEAQIEADDPESDNRSGKVAAIEWRALFHKASEEFISSSEMMFRTQLKEFYDHQMITSKLDPSGAELLGVPLSREEIESILEDLVIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8M1</accession>
    <name>D4D8M1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022394.1">
        <property type="nucleotide sequence ID" value="XM_003022348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8M1"/>
    <dbReference type="GeneID" id="9580941"/>
    <dbReference type="KEGG" id="tve:TRV_03458"/>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="498" mass="54910" checksum="60C3EE1E3A9EADDC" modified="2010-05-18" version="1">MDSSPPRKVPQGQSTAGVKRAALLPPFEPCSSPPLPRPAKRRVLKGEDSFSTYPTPVPTSSTAILSSSPSRIPPALQRTQSVTSERAPLSDVPCVMLEEDGEPITMGRSSASCSYQLSPNRLISRVHVKAYFKPASHPFDRDKIEILCMGWNGIKLHCQGKTYELAKGKTFTSDIRDADVMIDVQDSRVLVQWPRPERKDSNSEHTWDESSPIRNADSRSRHGYSESPLKSRERLLSPVSPSPAVQALGSADPLTSSRSVPNAVVVYEDESSPVRPKKSTTDPKSTSQSTERASISSDANARNSISSNLTKSDELSEHDEENDPIVFSFGPYGENLLPRMAAVNARDTPTASPHQKPLKRSASARESSSTKESTDSSRSAIQNHIINQLAFSRLSSTPFSTIVSNLPSDLVGTGSSKKPKVSNTFIRSIIEDTRCIGTVNRKGKDAAGKQLECEYYYTPDLDTDEMRKQAVVNELRKPGLRNCRKQHKQYFWKRPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8N1</accession>
    <name>D4D8N1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RSC complex subunit (RSC8)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022404.1">
        <property type="nucleotide sequence ID" value="XM_003022358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8N1"/>
    <dbReference type="GeneID" id="9580951"/>
    <dbReference type="KEGG" id="tve:TRV_03468"/>
    <dbReference type="HOGENOM" id="CLU_004447_3_0_1"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="406"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="78190" checksum="BB2094436197FACE" modified="2010-05-18" version="1">MDQSTGDSGNENKPTATSIDAQSGADETMASPSRPTGSQSGGVSPEKATPTQNPSDNPLDAPPSPKGQNDEMEDEEMGGTNDSKADNDAGDEGDTSMLQQQTDGNVDGPADQSKAATEASARSNLIAQTHAIILPSYTSWFDMNTIHPVEKKALPEFFNSRNRSKTPAVYKDYRDFMINTYRVNPVEYLTVTACRRNLAGDVCAIMRTHAFLEHWGLINYQVDPQSRPSNIGPPFTGHFRITADTPRGLQPFQPGPNTMVTAGKPHPSTDRAAAATPLSKSDLNLEIRRNIYDDKGKEVTPSESKDKETNGEDAVTNGTPAESSTKAMEASAKESKKSLNCYACGIDCTRVRFHYAKSAPVSTTTNPSELKYDLCPNCYLQGRMPSSHQASDFVKLEDSQYTTIQDREKPWSNSELLLLLEALENFDDNWQQISRHVGTRTPEECVMKFLQLEIEDKYLEDPVEGTSSMLGSAGGREPVSQLENPVLSVVTYLAQMTEPSVAAAAAGRTVEEMRRDLQKQLDKRTASTTKEKDTEKTGEKGKEAESMKAEDSMEIDTANEGQEASASSTSQGKTAQATIASIGLAASAARAGALASHEEREMTRLVGAAVNLTLQKLELKLAQFSELEAVVEAERRDLEQARQQLFLDRLGLKRRIKEVEEAFKAASLEGNEAGAAVAAQAQTIGLGENYTFQQTSADNGVNAVQPYSASGGPDYKSYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W6</accession>
    <name>D4D8W6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022343.1">
        <property type="nucleotide sequence ID" value="XM_003022297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8W6"/>
    <dbReference type="GeneID" id="9580890"/>
    <dbReference type="KEGG" id="tve:TRV_03554"/>
    <dbReference type="HOGENOM" id="CLU_040208_1_0_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="420" mass="46474" checksum="FD83A869A2E5E4D4" modified="2010-05-18" version="1">MAPLTSRFPLDDAEDENPVSFVNRDRAGIDTEQSTYQPHTMTSSYLSSVSVPATPSVLSQSRNVSQTDLARKKKDSQGMLLSESRLYALDVAGPLHHQQLRHHKRSKSYNPRSGMMGSSGTSTPRNQDGEWILRTGLALASSTREEKGQSWLVKRESSTSLVSHDEDGRKTHSRGRSDFQGCRSGMSTPLAQSRRGSHSHAPSKRSSRVDLAMTPSFPTVHPHQSGIVTPRSRDIPGLVPDFLDESIREELAALQTHLPENGNTDNNETGQNSTLPFASQEYYESDLSEDDSEDEEISEIEVHRLTQERGFGLGSWIDRLVEWTVFGSEDESVQPPVIHGSYRPGQRANLNVDSNTQEITELNPTDQLETASNSGMEKNDDPGSDTEKFSTTMKIIPADEEGGWANDVRWLLRVAGNAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y3</accession>
    <name>D4D8Y3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022360.1">
        <property type="nucleotide sequence ID" value="XM_003022314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y3"/>
    <dbReference type="GeneID" id="9580907"/>
    <dbReference type="KEGG" id="tve:TRV_03571"/>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="374" mass="41403" checksum="2DFD4BFFF2D7C738" modified="2010-05-18" version="1">MPSATATGADRPSGAHSRQHNQGNQDRKYTPEQKAAVLRVRKCSATAFYEILAVEKTATDGEIKKAYRKLSLLTHPDKNGYEGADEAFKMVSRAFQILSDADKKAKYDRFGGDPDNRFNAGASTSSPFGGFGGFQPHPGRQYAYEEEISPEELFNRFFGGAAGGGFGPFGIVSQASNGHFGNVRTLSLTNTAGGGIFDGGPQFVFNMGGGPGFRVHQFGGNRPRRRPRDTNEPDPSQTPPGVASLTQFLPLLLLFILPFLSNLFSSTSPSTPSFKLHTPDPPHTLQRMTPKLKLKYFLNPTDIEDYSPRKLHQLDQRIEVDYVANLRRECQSEINYRDRLVQDAQGWFFPDVEKMREAQDLELKSCAKLKALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9E7</accession>
    <name>D4D9E7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022135.1">
        <property type="nucleotide sequence ID" value="XM_003022089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9E7"/>
    <dbReference type="GeneID" id="9579032"/>
    <dbReference type="KEGG" id="tve:TRV_03738"/>
    <dbReference type="HOGENOM" id="CLU_054785_2_1_1"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29984" checksum="5F6113CE59F4A4E2" modified="2010-05-18" version="1">MSQSSNVITTLADNADISISDEGTIWYWVVTGIFSLSAVAFLVGSFVVRNPNVRLQYYLSALSSYILSMAYFAMGANLGWVAVEVEFRRVGQFVVIDNGTENPTRQVFWIRYAGWLLATPLLMTQLLLLIKAPLKLILHEVFMVSIVMMTGLGAALIPNAYKWAYFVYGFFACAALGWTMLKSGYNHVRATTPSLKRVYLMFCIAVSIIFLLYGLAWGMNEGGNFMSPTGEAVFYGILDIWGGPLYCVFLLWAAHRYYRTEMLQLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9J0</accession>
    <name>D4D9J0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022096.1">
        <property type="nucleotide sequence ID" value="XM_003022050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9J0"/>
    <dbReference type="GeneID" id="9578980"/>
    <dbReference type="KEGG" id="tve:TRV_03783"/>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_1"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="55"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="288"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="46701" checksum="6529337F2BA7A5FB" modified="2010-05-18" version="1">MKLGVSEDMLGRVFDGSGRAIDKGPKVLAEEYLDINGSPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVKKPTKDVHDGHEDNFSIVFAAMGVNMETSRFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFIDRQLDNKGIYPPINVLPSLSRLMKSAIGEGRTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERTFISQSAYESRTIEESLDLAWNLLRIYPKDLLNRIPKKVIDEFYQRSSKGRARPTKDTRDTAEPAARADNNLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9T6</accession>
    <name>D4D9T6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55 superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000199">
        <property type="protein sequence ID" value="EFE41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021985.1">
        <property type="nucleotide sequence ID" value="XM_003021939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9T6"/>
    <dbReference type="GeneID" id="9578869"/>
    <dbReference type="KEGG" id="tve:TRV_03879"/>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13736" checksum="795FC73B0E423247" modified="2010-05-18" version="1">MPGLKTIIALSFVLAIGFLLVILSAALWHNYLPLLVVATYVIAPIPNWICSRCASSDDFMESSNSGAVDFGRWFTGFLVVMGIALPAVLAHSGSIQVPAMIMSILGGLLIYGTIISFSMFFQETEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAD4</accession>
    <name>D4DAD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000207">
        <property type="protein sequence ID" value="EFE41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021813.1">
        <property type="nucleotide sequence ID" value="XM_003021767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAD4"/>
    <dbReference type="GeneID" id="9578691"/>
    <dbReference type="KEGG" id="tve:TRV_04081"/>
    <dbReference type="HOGENOM" id="CLU_465361_0_0_1"/>
    <dbReference type="OrthoDB" id="5355510at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="689" mass="75408" checksum="D00F0D302D50E8F6" modified="2010-05-18" version="1" fragment="single">APSPLFFLPASLFRVGFCPFTHTTQSHTHIHIHIYYPPSFSSLWCFFYSDIHLHCQQLEIDIPFLLLSLSRAASSYITLSLSLYLTKFGIPYTAQFIMTMPLRPLHFLSREDGTLTALVAVDELPHYVSIRGVPRTLSHSDTQGMTSLGTVKSRGQFYLIDSAIQHTSKSVGEKTNNPGRQVVTAAARGLEDFGQLAPAPQNSTADASAAQNPDWTPVTTGGTQTSTKHSSGHRHGKGGQNGNSAKKEYCSFWLRHGECDYQQQGCIFKHEMPTDKPTLDKLGLRDIPRWYREKHGVKGLGGAGGRNRHEGNGRNWRTENHHHSHHHLPAAAANPADRRDVNGHRVMTTETQVERPRATPTPPQQPNLSVLPHGHPTMYNNIPGTIHGPPMGLSAPVGLNMNMPANNPPLEGPKFPNRCDLISVDDFRKTPTPDHTVQDGAKPSLGNFPGNGNKSHVKIDLMDQPFPTGPGLLPTVPATSSNNVQGQNTVSHNNNLMLSHSYAPASLPLPGSTSLWTITGNEGDNWNLLPLTPFLPVAGAPPVNQQSNGQGTQIKKKPQRSRRLYQRRPSVDGNDGTDEEKNLRATNILPINTAITNLDFKGPASRAISPCFSSHPQSGSYASSPCSPRSGLTTNRFPDNFEFRGNGNHRYGSRGSPNSTQSTQTNRGINYDLFDLGLNNPITITAKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAJ7</accession>
    <name>D4DAJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000209">
        <property type="protein sequence ID" value="EFE41128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021746.1">
        <property type="nucleotide sequence ID" value="XM_003021700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAJ7"/>
    <dbReference type="GeneID" id="9578626"/>
    <dbReference type="KEGG" id="tve:TRV_04144"/>
    <dbReference type="HOGENOM" id="CLU_090091_2_0_1"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="27344" checksum="987A5322845409B5" modified="2010-05-18" version="1">MAPPRQRPVSTTATSAGAGAASSGAAAASTSAAAAGAVPDDSRSEASSTRERQGTTKGRKPAAGTTSSAAANTSAPSTGSNATLKEGKAPAADQRMDESGTVESQASINWSTMPLSVLHEYRYAYNLPCPSAFSSQINSILLSQGPGLGSATAISIRRKQLLQQLQSDRQQHDDSMQIDTDMDVKPRQEASNNTGRQDKVVHRLSAPAQGRVSKAQLASAVRKHFNNTAISEQDAIARFLYKVNEERRGKEFRLRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAQ6</accession>
    <name>D4DAQ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021693.1">
        <property type="nucleotide sequence ID" value="XM_003021647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAQ6"/>
    <dbReference type="GeneID" id="9576776"/>
    <dbReference type="KEGG" id="tve:TRV_04204"/>
    <dbReference type="HOGENOM" id="CLU_1038968_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30529" checksum="31965430F5D6BACF" modified="2010-05-18" version="1">MSDVGAKALSGEWERISNRLLEMKEDMIMSFEGRPCNIVDTENNLVEHLKVSKSEEVEKVESFFNPHPDSTLSGRIQRNQVCDESTEVVTKMEKLEPIAFTKEMDESAGNLGPRTEQSALGSLYYLINYGFELYGDRCIDPDNPREHGFKMASLLQSMIFPELKGDPFIDDIIHKCWHNKYRKVADLAEHTEALLVKESSAAKDTEAGSSEDVTWKKVLCQDLENCGLLEFLCSDEPVKLCFPLGWYIYSETADGPSEVEVWFTFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB96</accession>
    <name>D4DB96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleotide binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021548.1">
        <property type="nucleotide sequence ID" value="XM_003021502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB96"/>
    <dbReference type="GeneID" id="9578509"/>
    <dbReference type="KEGG" id="tve:TRV_04395"/>
    <dbReference type="HOGENOM" id="CLU_024839_6_1_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23487" checksum="ED31EEB0EDC5A48E" modified="2010-05-18" version="1">MSMGYLLPPPPEDVRHLTDDPSSPLMDTTPISWRGLMVSKAMNQLLHSVSWGPLDVLILDLPPGTGDVQLTINQEVVVDGAVIVSTPQDIALRDAVRGFGLFEKMNVPVLGMIRNMAYFACPHCGKQTKIFSRSNNHAAGDEGHQLSHGENTGVVAACKRLGIDFLGDIPLDARVCEDADRGMPTVVAEESDDRSARRNAFLDVSKKVAEKVGLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBM5</accession>
    <name>D4DBM5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021370.1">
        <property type="nucleotide sequence ID" value="XM_003021324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBM5"/>
    <dbReference type="GeneID" id="9578250"/>
    <dbReference type="KEGG" id="tve:TRV_04525"/>
    <dbReference type="HOGENOM" id="CLU_1788217_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="145" mass="15770" checksum="B83764D4F605F888" modified="2010-05-18" version="1">MLASLFSSSSSSSASSSLSTPEQDETMTFYMSIKWIAPDEPFSAPGDSGSLVYTFFDNSIVPLGIHYGSDGDESQAYLLDSWFTEIEAILNCDGYFCELTECKLGSVTSSASFLTQLNQATIIVMASYVLNLSSQKENNFSVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBU0</accession>
    <name>D4DBU0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021278.1">
        <property type="nucleotide sequence ID" value="XM_003021232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBU0"/>
    <dbReference type="GeneID" id="9578123"/>
    <dbReference type="KEGG" id="tve:TRV_04591"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="226"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="654" mass="72769" checksum="55D461B0BB7C21B1" modified="2010-05-18" version="1">MDAFDTPGQFVAALYKPTELLPIARHRQSLLYAIEKYPVVVLVGETGSGKTTQLPQFLDQAGWCSGGKKIAITQPRRVAVTSVAARVAGETGCQLGQKVGYSIRFEDVTSASTRIKFVTDGLLLREALVDPLLSRYSVIMVDEAHERSVSTDVLLGVLKKIRKRRPELRIVVSSATLKAEDYMQFFAGHDATEDNETARIITLDGKMYPVDCLYLESPAEDYVERAIKTVFDIHATEPEGDILLFLTGREEIVSATQQISEQAALLPQKAQALLPVPLYAGLTADQQLSAFEPAPENTRKVIVSTNVAEASVTIEGIVYVVDCGFSKLRAYDPSTGIEKLTTVPISRASATQRAGRAGRTRPGKCFRLYTEQSFLSLPQETTPEIQRANLAPIILQLKSLGIDNVVRFDYISSPPSELFVRAFQLLSSLGAVDDYAKLTKPLGIQMAELPVNPMMAKVLLSSTKFGCLDEVLSIAAMTTLQDNIWFNQDEKRGISPSIRQFAVEEGDHLTYLNIYQAFVTKGRKEAKWCRDHSLIHKSMMKAVSIRVQLENHLKRFGIDMARRQAATTEQIQRCLTTGFFAHAAKMQPDGTFRSITGGLTLHAHPSSLMFNRKAEWVIFNEILQTGTKTFIRDVTKIEKAWLLEYAPEYYEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBZ5</accession>
    <name>D4DBZ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein (Cwf19)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021215.1">
        <property type="nucleotide sequence ID" value="XM_003021169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBZ5"/>
    <dbReference type="GeneID" id="9578060"/>
    <dbReference type="KEGG" id="tve:TRV_04647"/>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="468"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="600"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="82410" checksum="D684993C04D7905B" modified="2010-05-18" version="1">MTLEDFERELAENNRKEREREEREHERSRRRHRHRSDRDRDEDSKHRSHRHHHRHRSPHGRHGRREEDEDDDERRRHKRSRHSTSNGEEREHRHKRRHRDRDGDRNRSRSADRDNTKEEPQEPAVESETRAKLQRDSWMEGPSAQDIDYIHRPKEKPQETPAARMLQVDFGQKLHEKELNRHLLDVAEDADTTRKSDPVEVDYTFGDEGSQWRMTKLKAVYRQANESGKTVDEVALERYGDLRFFDNAREEEIELDRRERYGKDYLGKEKPSGELFKARKLDMEPTRRNDSAIPAAELEPSAQGEPVKTESAPRETTALDASALNKLKAQMMKAKLRGASDAAELEAQYNAAVSGAANRKEADIVVLGVMDNRMLAGGNRAEVRAVETKRGRERGQVEENEDMTIEDMVREERRNRGGAGEGQRFAERIAKDAKFDNDLDYMDENASKLAKRVHKSEINLKNASISEFQKMNRILDNCPLCHHEDTGKPPLAPVVSLGTRVYLTLPTEPELNEGSTCIVPIQHRTNLLECDDDEWEEIRNFMKCLTRLYHDQGRDVIFYENAARPGQKRHAAMEAVPLPYSLGETAPAFFREAILSADEEWTQHKKVIDTLAKARQGGGKLAFRNTLAKEMPYFHVWFELDGGLGHVVEDPNRWPKGDLFAREIIGGMLDLGPEVIKRQGRWRSGTDRRVDGFKKRWKKFDWTRVLTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC45</accession>
    <name>D4DC45_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021180.1">
        <property type="nucleotide sequence ID" value="XM_003021134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC45"/>
    <dbReference type="GeneID" id="9578024"/>
    <dbReference type="KEGG" id="tve:TRV_04697"/>
    <dbReference type="HOGENOM" id="CLU_1511681_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="178" mass="19680" checksum="C15E94710049FE26" modified="2010-05-18" version="1">MSSAVAELDGYLHSMLSLKPPGVSGSKINGITSLCTANVQSESVLIQKIYTHFKRAPGTHKLGVLYVVDSVTRQWVELARKAGQQIGGSAPDGTYAAGVNRVTELLPVLMTDIINNAPEDQKVRVLLDMNQTQYLLQGGKRNLLCSAEYDRPRHLPAWRCLKTPKSPYHETPFFPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL5</accession>
    <name>D4DCL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sucrose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021005.1">
        <property type="nucleotide sequence ID" value="XM_003020959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL5"/>
    <dbReference type="GeneID" id="9577857"/>
    <dbReference type="KEGG" id="tve:TRV_04870"/>
    <dbReference type="HOGENOM" id="CLU_018303_1_1_1"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="632" mass="68510" checksum="125E85A7058F1DDC" modified="2010-05-18" version="1">MAYPGDREDNSTSPLLDDPERRSGEIWDDAAAVAKQAEKEEEAKSSWYLFLLALSIGGLQIVWSVELSNGSPYLLSLGMSKSLLAFVWIAGPLTGTLVQPYVGIRSDNCRISWGKRKPFMIGGGIATVFSLLALAWVREIVGGILSLLGAPPESSGVKVTVIVVATLLMYCLDFAINTVDNAPAHQQEAANAWASRLTGIGNIVGYISGYLKLPEIFPFFGDTQFKVLCVIASLCLGFTLLASCSYITERDPRLEGPPTSENPGVLAFFVQVFKSIRRLPPRIRKVCEVQLCAWVGWFPFLFYSTTYIGQLYVNPIFDQHPHLSKEEIDAVWEKATRIGTLALLIYAITSFVGSIVLPLVIVPGYRPPVASEASSPPQNRPYLSNRPSTSTLSFTASAGSAIEPAVIEPIHDPSRSDERGWGRWSSILSKLQVPGLTLRKLWLISHILFALCMFSTIFVSSPAAGTVVIATVGLSWALTLWAPFALISAEVAQRDAAHRRQRRSLRPRTASDPAPIGPRPRPLQSDVGAHERDVEEESSASVVDHDAGDKDETVDQAGIILGIHNVSISCPQIVSTLISSVIFKALQKPRGAAWDDSVGWVLRFGGCAALGAAWFTSTMGDGPSQGTEDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV4</accession>
    <name>D4DCV4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000252">
        <property type="protein sequence ID" value="EFE40319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020937.1">
        <property type="nucleotide sequence ID" value="XM_003020891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV4"/>
    <dbReference type="GeneID" id="9577768"/>
    <dbReference type="KEGG" id="tve:TRV_04959"/>
    <dbReference type="HOGENOM" id="CLU_057188_0_0_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="41058" checksum="B567A2613EBB380D" modified="2010-05-18" version="1">MEVPWSLPTRLPLAVHIDEVILARKIGRNGLLISVWTLFAITTLLLISRFAIRLRVHRQLFWDDILAGLAYIFLLCHNILATLAAPTIYLLLDLFTDNHGFMQPDILGKIDRLVKLVLSSNFLFRICIYLVKASLLALLWRLFRSLPKFRRAWLGIIVVTVIGFALSMILPPVACSDFTALGCISPRQIRLAAIDIYVSTVFDVLTDVLIVSLPVAFVLKSSLPMPQKTGLIVLFLLGLAVVIISILRTIETDGKTKLSPPSWLLFWSSMEATIAVMVSCFASYKSLFSARSRPSTYNPHGHTASVVAPTPAEVRKTRILNESDSREEIIHRTEFEVSYEMAPAGSSNRANPYSIPSNKSLQALPSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDC8</accession>
    <name>D4DDC8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000262">
        <property type="protein sequence ID" value="EFE40136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020754.1">
        <property type="nucleotide sequence ID" value="XM_003020708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDC8"/>
    <dbReference type="GeneID" id="9577452"/>
    <dbReference type="KEGG" id="tve:TRV_05137"/>
    <dbReference type="HOGENOM" id="CLU_025891_1_0_1"/>
    <dbReference type="OrthoDB" id="4173993at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57328" checksum="2B667CE85BC12F43" modified="2010-05-18" version="1">MSLAPIPVPGTDRQASPSITLGSNNPFRNRAASPSTPNSLLSPGLRPQRPLSTNPFLDETESFSPSSLPSPGMADASDLFENLSLEDRKRRPPPRPENIPPLSSSSLNAGRPLPQHRRPSNHEASRSRSTKTGQLIDVFADPSESTLVGSSAASHSAAAARPERRPRRNSDSSLMERPKLLDPEEDRRRRERRHREREARHRDGKSSRSRRGNNYKLDIIDKLDVTGIYGPGSFHHDGPFDACNPHRNRKGSRAAPMQAFPKDSRNMAIGGAGPNNNKLDLNQIHGRGQEGYSDFSTGISSGSAISSSAMKADAAVAFNPTSQIEQVHSDISMGLGTSTFLEGTPASRAAIQRKESESDTMQAGLQRKKSLAQKIRGINNRSISSGRVMSPEPLLHRRPSEAADNPPRHAPPPPPPRATSSRRANTNDKNPFFSNNTNSTSNNNGFGSSSQDYDDAYDMKSARIQNHRLVDSDDGYGGRPRAMSSPRGRPERKESSDGMTSPTAEDPKPASGFISRVKSLRKPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDJ1</accession>
    <name>D4DDJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020676.1">
        <property type="nucleotide sequence ID" value="XM_003020630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDJ1"/>
    <dbReference type="GeneID" id="9577375"/>
    <dbReference type="KEGG" id="tve:TRV_05202"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="121"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="481" mass="52680" checksum="DF4B34BA66892FFE" modified="2010-05-18" version="1">MHARAFSSSFTPDRYFIFCWSRVHLPEGASLNTNPACFSLPPPSLSLSSPAPLLLLCRLSFGKDRSRVFLRLLSPMCFEMFRFKPSSWFSSRDTMDSQAPQVGAAASISCIEQSLCQIPIFSNAVYYPNWRIYKSSPPSSLKLGYVSHVFYAFAWVKPDGTVYLSDEWADEQMPVDGAKGCIRAFTQSKRQYPQLKVILSIGGGGAGSENFAAVAADPVLTANFVETAKNLVDKFSLDGLDVDWEHPSDPQQGINYISLLAALREQLPAPQYILSSALPAGQWALQHINLHLAQYYLDVINVMTYDFSGPWVPQCGHQSQLFAPEQPHNDAAHLSCSSAVSYLLAQGVPPHKILMGIPVYGRGFPGTNCVGQYSCPAPDGSDKPVDDGAGNEKEIVFDYCDLPVPGSIEQHDPEVGNAAFCVDNEQNSGFISYDSPQSVKLKAQFVKQTGLAGLFYWHIAADSTTAARSLIATGYNTMHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDM1</accession>
    <name>D4DDM1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020706.1">
        <property type="nucleotide sequence ID" value="XM_003020660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDM1"/>
    <dbReference type="GeneID" id="9577405"/>
    <dbReference type="KEGG" id="tve:TRV_05232"/>
    <dbReference type="HOGENOM" id="CLU_015502_1_1_1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="616" mass="67521" checksum="03CF15312C61BE7C" modified="2010-05-18" version="1">MSFATTNRSGEKPSSLACLACRRKHLKCDGVMPICGRCRKGQLGCHYTPSRRGYKPGSRNQYAVSYTPVPLLTPSSEYTAPATLQLTPQLSTFSFVSTPLPGTVSTADDFSSDQSSSVPTWQTTDHHSNNTHSSSNGNNSNHNGLYNQTPICVDKPVAAAAAAPGLAGGSQYGVTDLQGDSYLIDFYYAYFHDSHPILPPAHFLPRLYPLPTCLEATLKFIGAHFVSGVSPDAYRPAVISSIAKSEVSCYKVQSLLLLSITLHGRNERAEGVKAFTEAAGLAMKLGMNMRTFAPSVVGEDAVLCENIRRTWWEVYMIDAMFSGFDQTPCQISSSVIMDVPLPCDDLSYSAGIYLTESPTAAQFYDRIFEDEDGSSEYSSYCHAIEASRVLKRTLDLTYAPEDPEYDQIESIDASIGSWFHHLPPSRRDILAVDDQVDQVMFRAFMIIHCASIYLHTPQSNLLSTPVAMSSIPCARRWIRLLRTNPSSNLTHAIKSIKAANGLANLAALRSPSIKHSPFFICGMVLSALVQLCACSIRASDTLEPRRDRIALLIGELKALGPTWSISRLVMRHIKMVAREVLDIGVRPPSYSTVEDTGPDIATIVNNDIWLGDIPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDN2</accession>
    <name>D4DDN2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020645.1">
        <property type="nucleotide sequence ID" value="XM_003020599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDN2"/>
    <dbReference type="GeneID" id="9577349"/>
    <dbReference type="KEGG" id="tve:TRV_05243"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="313" mass="34436" checksum="EF2BABBB21320D64" modified="2010-05-18" version="1">MSAFSGAFGGLVANGISLIHTTIGHWRVLFLVEGLPTVAFAFVVLFFLPDRPETSKFFKNEEERQLAIRRMNQGQQSEGHNSLVMKHVIASLKDWKVYGVCIVKMGHDASLATISIFLPTILHSLGYSKTAAQYMTIGPYMAGWVVMVSFSLLSDRLRTRGPFIIGGTALAIIGVSLMYTFPAKENPKAALGGVFLLVIGIFPCIPLEVQWVSDNAGAESKKAMALCMIVIAGHCLSILASKSFPEQEGPMYIRGYAIVLSFLCLSFVTSVVLYTRHQIVNAQRDKKYGKPNPLHRVDTSILADKAPMFRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDU4</accession>
    <name>D4DDU4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020586.1">
        <property type="nucleotide sequence ID" value="XM_003020540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDU4"/>
    <dbReference type="GeneID" id="9577296"/>
    <dbReference type="KEGG" id="tve:TRV_05308"/>
    <dbReference type="HOGENOM" id="CLU_204096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="53" mass="6251" checksum="696DF94F3A9AE2CA" modified="2010-05-18" version="1" fragment="single">KKEKKEKKKKKEEEEKKKVGKLKKKKRRKEEEEEESRKGLREGGGGAWPVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC6</accession>
    <name>D4DEC6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020375.1">
        <property type="nucleotide sequence ID" value="XM_003020329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC6"/>
    <dbReference type="GeneID" id="9584114"/>
    <dbReference type="KEGG" id="tve:TRV_05493"/>
    <dbReference type="HOGENOM" id="CLU_020434_0_0_1"/>
    <dbReference type="OrthoDB" id="4346289at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="767" mass="82140" checksum="B27DF7B86C1DA9B5" modified="2010-05-18" version="1">MAEPMTFAAPYGRADERMADMVTPDGHGYAEPMFNEPVMEPWMDGVLDETLMMAAPSSWDNFDALDTAVSQATATPNAFDSMLADCSLPADSQASSNGDLTVSPDMLNISSNLALPDSEISSLLGTEFSNSFSTFDSPTTNNTSFSTQTTPESTAGDNCELVFEQVASAFKDLARARAAADPRPISRKQKQRDASIALYLERLRDTCNEAVAALNSGADSTTAMGHSAAWFNSNQVSMSSQHSSSGTSSFSTSSPSEGFTEFHSQSQSTRSSVPSQSPTLDQSRPQFQQPSPPAPPSGGIELVMDLNMNTATSLPRKHRPRTETQRQRYLAVRNQGACEKHKKQHKRCTCIDKAIPLVSTCTATSTASSSPQAGAGASTGIDATISVLSHTKGRHSVRKTSPLRRVPGVRGARDSLSPTSGEDNWSGLGHGGEVLIRNNRPDGIAKGEAGMDCSASYLLQRQGKLDQCRDSGHDIGNSHDKGVSRHRVASSERVSTLPTNTGNVAWSITPQAVLDSNINVRSRTTGGCEPARNRDAGGHGYYARCADSSVSATMCLGNRDQGRRAISTASSFVFPDGTWQCPHGQFATSSQSHSANIGGSSNIDGSRQAQISSYLHLRDKKEDKQKHTCFHTWSNGDCNSSSSSATTGANARAHNINNNCCTNAAAHLRRTTDLVFSTITNSQSLKNRSAIRDECCAGSMSSALLQPSASNISSAYAGLRWYIQAYINDSVRSSLKRATPHQLEFALWCFIWISMLVLSAIFKGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET3</accession>
    <name>D4DET3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000310">
        <property type="protein sequence ID" value="EFE39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020261.1">
        <property type="nucleotide sequence ID" value="XM_003020215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET3"/>
    <dbReference type="GeneID" id="9582802"/>
    <dbReference type="KEGG" id="tve:TRV_05673"/>
    <dbReference type="HOGENOM" id="CLU_005249_4_0_1"/>
    <dbReference type="OrthoDB" id="4172309at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="755" mass="84210" checksum="5FECB0909229E2AC" modified="2010-05-18" version="1">METSDFEVRIPVHPGDKEDYNDINMLDTSSSDAGFSSDEETPSNGQISQEAKPSVTIVNEELEELEGKSKEGFHILTKLETILKKHPSSTGATEALRKQILETMDQGKSHPTITIGVVGATGAGKSSLINALLGEKRLVPTSGMRACTAAITEISYCHGPWNYEAEIQFVSRSAWEEEMRLLFEDMQDGLDELPSTYDSEFGIACAKFRAVYQLDPRNTQIEKIMEVPNVATVLGSTKYVSGNNATDFYNELKKYVDSEPRRLVSDQDIIDTNDTISQNKSMQLWPLVELVRLHVKAPVLSTGVVLVDLPGLLDVNTARGTLAQKYIKNCSSLWVVAPITRAVDDHSARTLLGDGFKRQLQLDGGMGQLAFICSKTDDINLSEAADDPGLKHAREALDNFCEEKKQQAKAMGLKIQSLKQKDKRIRLKLENLIDFAIQDDTKVAPEINPIQSPSNHGAMNISPSPSPSPRKREFMVSKKSLTEKQATVKAQLQSLETEVLSVRKEIKLKQREFERCCIEKRNKYSETRIREDFVAGLLHPRNTSQDEEGTMAKEKLDVFCVSSKAFQILEGRLKEHKVMKGFIVPEDTGIPQLQRYCLNLGVTARMAKHASFLNNLGQLVNSLQLQASGQDKLSLRSKQDDQELLQAEFNNLKEVLNTTILNLSNALLEIRQHLYASLGMSHFQTASRSLKLICVDNAAIAAKNAAERTLSRWNRVKKHGGISYPTYKAICRRFGEFRDGKGNHYGANISTTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFB5</accession>
    <name>D4DFB5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020088.1">
        <property type="nucleotide sequence ID" value="XM_003020042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFB5"/>
    <dbReference type="MEROPS" id="S10.014"/>
    <dbReference type="GeneID" id="9583852"/>
    <dbReference type="KEGG" id="tve:TRV_05861"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="540" mass="60084" checksum="15D397787CD62003" modified="2010-05-18" version="1">MEYKFQRISHLCCLYSFIHQEQHIKKLNLLFYLPQRKHKAVLNMRFTQIVAAALCLGATEAAVAPIDRARKVLGNQHAFDKRDASGDTAKAPKHLTSKNKKFYVDPTSIPGVPFDIGESYAGNLANTPAGNSSLFFWYFPSENPEAKNEITIWLNGGPGCSSMIGLLQENGPFLWQPGTDGPVKNPYAWSKLTNMVWVDQPAGTGFSPGPPTVKDEIDVANQFSDFWKNFMDTFDLHHSDVYLAGESYAGQYIPYIASGMLDRKDSEYFNVQGITIIDPSIGATEVIIDAPSVPALHRFNNIIDLNETFVNDITKKWESCGYKKFMDDALKFPPAGPMTVPGKSAGCDVWDEIIAAVKEVNPCFNIYHLRDNCPSPSNVMNGPKNFFNNKQIQEAIHAHPTDYRLCGESQIFGPHRNDRSVPSSYGPLASVIERTNNTIIAHGDLDFLLFTEGSLASIQNMTWGGLQGFQKEPSDKFYVPYKDGSEVGGAGFVGKTHRERGLTWVTVDLAGHEIPQYAPTAAYRMLEYMLGRVQSLTETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFD0</accession>
    <name>D4DFD0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric-chelate reductase (Fre2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020103.1">
        <property type="nucleotide sequence ID" value="XM_003020057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFD0"/>
    <dbReference type="GeneID" id="9583867"/>
    <dbReference type="KEGG" id="tve:TRV_05877"/>
    <dbReference type="HOGENOM" id="CLU_010365_1_1_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="130"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="489" mass="54582" checksum="42DCE6C9776E641A" modified="2010-05-18" version="1">MFAGRNNIFLWATGWSFRMFNIFHRQAALAATLLAIAHSIAFTIFFFLIGSGIYIKRFTEKWFCMGVVGTVVMSFLVIFSCLWLRRKTYELFLLIHIALSTVTIISMFYHISVYGGEYDPYLWPLVAIWGFERTLRIIRIIYCNLRVRFAGGGLQYTSSVAYYDEVSDIIRLEVTPAATGISQKPGRYYFLYQPFRWTGYESHPFTLGAWAETSKVATEKLSETGSSSPVENSKSDGVQQVANVSKDQNPRGSPSNETTYVFWIRPYNGWTRQLRDQCLKSSGTAISTTLLLEGPYGDSAPLWAYESVLFIVGGTGIAAAVPYIQDHIRRASATGTGTCTKDMTLVWSARQASYVHNVASRELQPALERGDFSASFYLTSGDKSAASAVPSPACTNTTSSLDTNVLDELTKDSKLQSLTAIPKYEVKYGRPDTKSIILERAKSANAANSRLAVLVCGPDSLADEAREAIHNAMLQGYRQIRYIEDAYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFD7</accession>
    <name>D4DFD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020110.1">
        <property type="nucleotide sequence ID" value="XM_003020064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFD7"/>
    <dbReference type="GeneID" id="9583874"/>
    <dbReference type="KEGG" id="tve:TRV_05884"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43276" checksum="711AD23800602F4C" modified="2010-05-18" version="1">MLTFGSDIKEEDEEDDPTGWRTRNNQTRIPWPTMEGLFFNVDNGCRWIYALSLDDSGRRDSLRCARADHVNTDVKLQLGPSYGGFLAALPPNPSTSALAGKATDKLVAEFRYLQAQASGSTAKFMEYLTYGYMIDNIALLITGTLHERDTRELLDRCHPLGFFETMPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIIRNTLYKNYLEDFYRFINTDPELKDSPTSQVMCEALEFEADRRAINITLNSFGTELSKAERKKLYPEFGKLYPEGSLMLSRADDLEGVSLAVTVVADYKAFFDTVGLNQSGSGAGSEGKSLEDLFYQREMELLKLVFTRQFTPAIIYAWVKLREQVSSYRYSVLCQAYKLIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFL7</accession>
    <name>D4DFL7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_05968</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019999.1">
        <property type="nucleotide sequence ID" value="XM_003019953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFL7"/>
    <dbReference type="GeneID" id="9580168"/>
    <dbReference type="KEGG" id="tve:TRV_05968"/>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="343"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="559"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE39375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="819" mass="92345" checksum="A8C070CCFC41158B" modified="2010-05-18" version="1">MGLFGYVGAKGRASKRATPNPTSTPQSVSSDEYVEPEGSDGEDDNLKGMLYVVEKFTLQSYSQKSQAVKQDPHFGYKDFSSLALKPDHANRPLWIEPLKGTITLESFSPLASQAQDFLTTIAEPLSRPTHLHEYRLTGNSLYAAVSVGLLPTDIINFLDRLSKTPLPETLKSFIINFTKSYGKIKLVLKHNRFFVESSDTATLQMLLKDEVIGPQRIESSEITQQAAPKMGGLVIPGTKDAAMMKQAPDQRAAQVSERPAQSNEDDILVNLREEDDDEEQAQVHSFEIPNTAVESVKARCQSMGCPALEEYDFRNDEINPTLDIDLKPIAQIRSYQEKSLSKMFGNGRAKSGIIVLPCGAGKTLVGITAACTIKKGTIVLCTSSMSVVQWRNEFIRWSNIDPSDIAIFTSDNKEKFRRSTGVIVSTYSMVSQTRARSHDAEKMMEWLQSREWGLMLLDEVHVVPAFMFRTVTSAIATQTKLGLTATLLREDDKIKDLNFLIGPKLYEANWMELAEQGHIAKVQCAEVWCPMTTEFYTEYMREKSRKAALLYIMNPRKFQACQFLIDYHEKRGDKIIVFSDNVFALERYALKLKKAYIYGGTPQNERLRILENFQHNEQVNTIFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTDEMFYSSKRQAFLVDQGYAFKVITHLQGIENLEGLAYATAEERLALLADVTLQNETSAAVEENADDLFNDRSAGGKSRGNKKSVRRNAATLSGLAGGEDMAYIEHNKSRNKQLKERSSFFKKIDRDRAKRKKMLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV7</accession>
    <name>D4DFV7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019862.1">
        <property type="nucleotide sequence ID" value="XM_003019816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV7"/>
    <dbReference type="GeneID" id="9584613"/>
    <dbReference type="KEGG" id="tve:TRV_06060"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="130"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="29843" checksum="5A25ACE5D6DC9452" modified="2010-05-18" version="1">MATTNGEVVMGDMDYDGRVIIYIIKADQTSYINYMKPLILAEELQFPHVLSVIDTRDEWFYSIHPERYVPSLKDQDPVTKEKVIVFESTACLQYLTDRFDTDGFWTGRTAAEKGAILSWTAYQTAALGYAPITTAIIISIIPTTNNGAVPRPSTGFTSRKGIPLGLIQLNSPVQLRSELHANTIRQWDILEKRLKEPGQDYIALKDRPTVADLSYFPFAMPWMFSFFGVDVKDWPHIQRWGERMLSRPAIKRVLERAPTLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG07</accession>
    <name>D4DG07_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019821.1">
        <property type="nucleotide sequence ID" value="XM_003019775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG07"/>
    <dbReference type="GeneID" id="9584572"/>
    <dbReference type="KEGG" id="tve:TRV_06109"/>
    <dbReference type="HOGENOM" id="CLU_042679_0_0_1"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="44696" checksum="A72660923EAC46AF" modified="2010-05-18" version="1">MAKAPQTKGAFLPTEIVITILSFASDEDTVNENWQSTLFSCCLVCQQWYSAAIPFLYSKPVISARNYDSFAGTLDVRGKARHNIQEPLGNFVKHLDLGGLAHSGSKSVTARLLRACKEELEVFVAPASTFSLTPMSKCLNLRIVDLSVLMTIVPFLSIPHAVRNLKHLETLRFPPEMSHKGLPKVNDPHNERSPPLYQWPPKLKRLQLWRVHDSIILGNFIWPETVTAVTIIESNHYPFNTILQTLSTDGACHRLQRVRILSSRQTDEVSTLAPLCFQMEKLKFLSLQGCGCDPGFYRRIITMSPEMAPLEILEISPLPLEHKLRVELVRDLKAVCAVAFPRVRLLGIAASCIDYVSEWFELEMDKVLMENARNSGHYDKEKLENGRIQTGVYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG52</accession>
    <name>D4DG52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019777.1">
        <property type="nucleotide sequence ID" value="XM_003019731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG52"/>
    <dbReference type="GeneID" id="9583700"/>
    <dbReference type="KEGG" id="tve:TRV_06154"/>
    <dbReference type="HOGENOM" id="CLU_3320326_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="39" mass="4211" checksum="6A77739C154A4214" modified="2010-05-18" version="1">MAMKSGEKITARRAESVDLDVDVDGDDDVDVVVVVVRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG75</accession>
    <name>D4DG75_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019754.1">
        <property type="nucleotide sequence ID" value="XM_003019708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG75"/>
    <dbReference type="GeneID" id="9583688"/>
    <dbReference type="KEGG" id="tve:TRV_06177"/>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="14">
        <location>
            <begin position="118"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="13">
        <location>
            <begin position="414"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="602" mass="65654" checksum="E488AF760D9A0F12" modified="2010-05-18" version="1">MVTVEGEVEAVEAGIIREMKLSRSIRVSSGDAEEEKKKKKKKKKSQRGCLNKRFWWENASLGRLQPRMSSSYTASSLSLSLSFAALATHYSLSHYSAALLLYLYTTTASTLLLLSTMSAKSIYEADGKAILNYHLTRAPVIKPSPLPAADTHNPPPKLASLDFQPDTAVEAVLDQAEATYPWLLAPGARFVAKPDQLIKRRGKSGLLALNKTWAEARAWIAERAGKEQQVETVVGVLRHFLVEPFVPHPQDTEYYININSVREGDWILFTHEGGVDVGDVDAKAEKLLVPVNLKQYPSNEEIAAGLLSKIPKGLHNVLVDFITRLYAVYVDCQFTYLEINPLVVIPNEDKTSASVHFLDLAAKLDQTAEFECGTKWAIARSPAALGLAATTASTSSKVTIDAGPPMDFPAPFGREMSKEEKYISDMDAKTGASLKLTVLNANGRIWTLVAGGGASVVYADAIASAGHVSELANYGEYSGAPTETQTYNYARTVLDLMLRAPLRPEGKVLFIGGGIANFTNVATTFKGVIRALREVAPVLVEHKTQIWVRRAGPNYQEGLKNIKAVGEELHLDMHVFGPEMHVSGIVPLALSGKTTDIKEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGA8</accession>
    <name>D4DGA8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000349">
        <property type="protein sequence ID" value="EFE39125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019749.1">
        <property type="nucleotide sequence ID" value="XM_003019703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGA8"/>
    <dbReference type="GeneID" id="9583672"/>
    <dbReference type="KEGG" id="tve:TRV_06212"/>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="243"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="573" mass="63741" checksum="348D24C0C5D0BBCA" modified="2010-05-18" version="1">MEDKGPEAAALASHFAARDALISKELSLRSDTAFRNALSPVASQACAIVSHIREAEHASIWKHDPSNPDNEEGIELYPGMMFGLAKRKLESTHLWRIAKRMPKGALLHCHLGAMVEVDWLFERILAVEGMHVCSSEALDTEAARARAVVLFKYVTPKPGSSHVSIWSSAYQPDTYVPAAEAADAFPSTGRQGFVNWLYDRSVISERSSIEHHLGVDEVWRKMAAAFPTLGSLLGYEPVYRLFLRKMLQNLAADGVRWVEIRDVFGSPFAREGQDVPDTGFNYRVAVMGEEIEAFKKTEEGKNFWGGRLIWTALRFLDADSIVASKLIDVEKANKRDPGMKDCLEAKKAHPHLVAGFDLVGQEDLGQTLAALMPQILWFRQQCISQNLNIPFFFHAGECLGDGDSTDRNLYDAILLNTRRIGHAFSLFKHPHLIDIVKQRRIMVESCPISNEVLRLTATVLAHPLPALLARGVSASLSNDDPALLGQGTSGMSHDFWQAVQAWENLGLAGLGSLAENSVRYAAFEDEDDEEWVGGIDTGYEGGGVKAERMKLWRQEWEAFCQWIVDEYGAEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGL5</accession>
    <name>D4DGL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polarized growth protein (Boi2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019648.1">
        <property type="nucleotide sequence ID" value="XM_003019602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583548"/>
    <dbReference type="KEGG" id="tve:TRV_06320"/>
    <dbReference type="HOGENOM" id="CLU_246457_0_0_1"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
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        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1497"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
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    <feature type="domain" description="SAM" evidence="8">
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            <begin position="247"/>
            <end position="313"/>
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        <location>
            <begin position="734"/>
            <end position="885"/>
        </location>
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            <begin position="74"/>
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            <begin position="1529"/>
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            <begin position="103"/>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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            <dbReference type="PROSITE" id="PS50003"/>
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            <dbReference type="PROSITE" id="PS50105"/>
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        <source>
            <dbReference type="EMBL" id="EFE39003.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
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    <sequence length="1549" mass="171656" checksum="59462EED8F40C832" modified="2010-05-18" version="1">MPQRPTNDFDARGADELTLRRGDKVELLELDEGFGDGWYLGRHVTENRTGLFPGGGIVYTVIAPKIGVRKTKDATLSAEPPWDPATPEVGSSSLGSSCDPVSPVSNDETTPQPSRHVSAIDMKPLSDAEAESGSGVATSHLSQQRPASAGSAQPSPTIQRTISETLGNMSISGEESPVLNETLSVIDEHITNFSTPRHSIATQENHSVHDSSSEYSSYPDHRMSYIRGEETDEEEEQIPSEAQVRKWDHRQMARHLREIGVDPKHCDIFESQEISGDVLLDMDQEFIYMREFDFGVMGRRLKTWHKIRAFQEEIQGPRHLRKGSSHGPEDYDRSQTKSVMSGSYLPRIPSLGERHHHNPRSSRDRSTVKYRDTSYGTQASAPPLSQPHDADATTRPSADSIRRSNHHRYSSIENTSVFPLADSSAFSASRKAPAPPHEKKPSFDRGWTMNAPLTANSSSNGQRPSSSLAATKHFYKTESNKTDDSSNGFGSPDIDRGYFSGGDVEGQKQRRVLRKRDSSKRSYSHSRHSSLAAVADDKKKRHTRFGSTGSMRDLTSMKPLYPKTHSQDITNSALELLEDESHSPTVTNLETTPESPTGFLSSIVGYGKSHEASGRSSPLPSTSSLKAITPKVRRTIGLRAISDAVTGSEKTRISSPIPSSGRDLPQSPTRTDSSTPSGTGTSRSLEMDSMESSRLESLAVMKNGNGSQRSKSKKDTSAYRRGLEKKTPKEQMKDADYYGWMKKKSFNLMTTWKPRLFILKGRRLSYYYSEDDTEERGLIDISSHRVFRADQDAITSLHATLTRTKPLPTTTSNNDIQHEETEPEEKTGGSRRNSSAEPPFIFKLVPPKAGISRAVQFTKPAIHFFQVDNIQQGRLWMAAIMKATIERDLNLPVKTTNKQKTITLKQARLLAQSSPTPPLDSKSRPPKPEEESSRNTSTSNSATLATTAETSTTDFQKIAIDTGSTSLFPDSVSVDQTQTSTSTNGSASFYPPYTGDAYLNTVREHVGLRDYTQQSPKSAPFRLLVLADPQLEGDTSLPKPDDAFLPQIKKHWEDVTSAGSISECYFATVKGIRDVVLTDIPRLGGTIRKRLDLLGNDYYLAHIYRTLSWWSRPTHVTVLGDLIGSQWVSDEEFNIRSKRYWNRTFRGGVKVPDDMMATGRDGYTQQTGVSMGQEIVLDIDTDTWSNRIINIAGNHDIGYAGDISQKRIDRFEREFGRANWDVRFNLPVTELALDLNDTHRKSGSIPSIHLVVLNTLTFDTPALDVSIQGKSYQYLNDVIDRSRPVEDRTTFTLLLTHLPLHKQEGVCTDPPYFSFHNEDDQHPKDDQPRFKAGGLKEQNHLSDYVSHNGILQGIFGMSGDLNAPYSGKGRNGLILTGHDHTGCDVLHYVDRKTGSDGESGDAESGDAEGERISNAAWSWNAKKYPTEVPTGVLESTSSASGFDSAFTPTPAIREVTLRSMMGEFGGNAGLLSVWFDAESSQEWKYEITTCQLGIQHIWWVIHIVALATLIAALTWVTILIVPSRSPLVDKRKVSKGATEEKKNKDSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH48</accession>
    <name>D4DH48_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06503</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000372">
        <property type="protein sequence ID" value="EFE38814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019459.1">
        <property type="nucleotide sequence ID" value="XM_003019413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577920"/>
    <dbReference type="KEGG" id="tve:TRV_06503"/>
    <dbReference type="HOGENOM" id="CLU_003364_1_0_1"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="297"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1305" mass="146940" checksum="F2C6E6307AC8EE87" modified="2010-05-18" version="1">MDDHHSTYIPFEGLDTYKPVKEPDTLPPQFTSRPPLSDPSDPVDRDASSVIILNPLLSSKPTSLRKIKSIGGDLDEMLINLDVSLSAGMFKRASLLLRRLAAAYPQESPELLDLHNKYLRSMITYMIVNRQPDLVWYAQRWYEVDMGLLSVKPDAITLAWMLRMSLRMLAGPKRERTVRRYWQSAVSRGIHEDILQSSILPESELGLLSEICFHVSESSAGNVEPDLAGPDMELDLKPKVTDESVLPPNEILNTDQKGLGLESLRESLSLFNPSTEFTPKKLWGRTPEEREQNRKRLRQEQLERDSLTSAIERWRKESEGVIGQRRQVEAKLNAFMYEWYQGVLGKIKEELELAKRSESKKKLTPEESERCEYIPFLLAIGPSKLAAVTILSVLGSIGSSGMDKGIKLSSLFTNIGRAVKDEYIIETTRRSAVEEAQSENEVYYLNKTFRQMKVYNSTGKFRSYMQKHTKDQPPVHWPASTEIKIGALLSSMLFSTAEIPTSHKDPVTEKVTYAKEPAFQHVYQLQKGHNVGYVQLHEKVVERLRKEPSGNLLAKHLPMVSTPRPWVSNNQGGFLTQPTQVVRTRHDDAQSQYLQAASDRGDLDELYKGLTILGKTGWKINRPVFDVMLEAWNSGEEVANIVAANLNLAELEKPDADDHEAVKAYYRAKTRADNKKMGNHSQRCYLNFQMEIARAYLNESFYLPHNMDFRGRAYPLPPYFNQMGADNCRGLLLFSEGRVLGESGLRWLRIHLSNVFGFDKASFQEREQFAIDHVDDILDSANNGLKGKRWWLQAADPFQCLAACVELKNALSLPDPTQYVSHLPVHQDGSCNGLQHYAALGGDAIGARQVNLEPGDRPSDIYTAVAEHVKASIASDAKAGDPIAKLMDGKITRKVVKQTVMTNVYGVTFIGATRQVRRQIEDHYPELAESDEISKCAVHVSRAIFSALNSMFSGAHDIQFWLGDCANRVTRSLNPSQIEEIRKELDSPSKTDLSKKLKFNNSVIWTTPLKLPVVQPYREAKARQIPTSLQLCTIKDIRGANEVNRRKQLQAFPPNFIHSLDATHMMLSAIKCDELGLTFSAVHDSFWTHAGDIDKMNRVLRDAFVRMHSDDIVGRLAAEFNARYSNNLYLAQVRPNTPLAKKIKALRAAKGRSGKQDKVYELLEEYKRIELLKSEDPAEQEQGRNMTTPGSLFAATEGADDTLVSVQSLGVAGMGHVPPPEEQKALEDAMTAESSSSPVDAVPEIPEVKGPQECEADAELSTKPKKKSKAQAASVWVWLPLTFREVPKKGEFDVRRLKESQYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB6</accession>
    <name>D4DHB6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019405.1">
        <property type="nucleotide sequence ID" value="XM_003019359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB6"/>
    <dbReference type="GeneID" id="9580121"/>
    <dbReference type="KEGG" id="tve:TRV_06572"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="41070" checksum="FD349C0ADF75D035" modified="2010-05-18" version="1">MENKQYLDFTAGIAVTSLGHSDPGLSQVLSEQSEILIHASNLFHNKHTGKLSQALVSTTLTSGAMRTATQAFICNSGTEANEAALKFARKVGHSLDTTGAKHEIVSFQGSFHGRTFGALSATPNPKYQAPFAPMVPGFKYGKYNDIEQLPTLITDKTCGVIVEPIQGEGGVNVASAEFLTALRARCDQVGAVLIFDEIQCGLSRTGSLWAHAHPSLRPKDGSKPAHPDILTTAKALGNGFPIGATIISSDTVGKYIKVGDHGTTFGGSPLACAVGNHVLTRLANKDLQDSVNSRSQTLIKGLKRLQERYPDAVSEIRGRGLILGLQLTAPYISKVSDILGSARDKGLLIISAGEGCIRFVPPLVITDAEIEVGLGILDEAMSEVVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHX3</accession>
    <name>D4DHX3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019174.1">
        <property type="nucleotide sequence ID" value="XM_003019128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHX3"/>
    <dbReference type="GeneID" id="9577171"/>
    <dbReference type="KEGG" id="tve:TRV_06780"/>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121214" checksum="82F4BE80CAB6AB50" modified="2010-05-18" version="1">MARSSQESDQDRSEYADRRASEGYGQATPNSNRGGSLDQTPSPSSDFLLQRRHRKQGSSTFRLESPTGPPSSNSPWAGVSRRGKDTIRHQSDDSELVIPKRNSQQRRQLHTPKPSIGSSPLSNVVSHEENDQRDAPYTPDGQSRVHHRQSPSVGLDTDPAQIVNLALSLSDSRNRVSSSRTVSSGIQRTRLSSSMIHSKPQGLQSPRISEIETPTRRPSTSQGTVDLRYGATHYGEVQLSHATLARAEKAKQHFELFEHYLRLLPHLPPLPSPGDASGRHQTNRGYQEDTPEGRQYNPLQYLRNRKVRYRERQAIDSEAAGWGDVEKVSEWVDSIVQAPNLHLREPDEYIDLPEFQPSASRVDPEDKSDRTLTHTKSGEVLRRRPRMDWATTPLDLLADIVWYEQNGNKAKVEDRHGKKLFPRGIITRHHTDPRAIQVESPGSTEQSNAQVDASSEIDDIQYLSTPTPAGSRSQQNAERGRLRHRLAHSINLTPNHSRSRKQSKSPVKKRPRSSSESSRHSYGSNNSESWRRISKTKTREFGDNGKNSRRNAAVLDTGRPVTPNQASLDTENIHKNHLRVPNTPENTLLPNPDFESNPHISPRHEYSASNSSLASDGGINGSRDMPNQDDSGPFQTPGPRGFFPNMSISLSPLRGRSTSPSRRHPFHLGHSRKPSRQKQGQILDFTESQGDLGTLSHRRTTSNLSPPGSPSVPEGQKTPVFRRADSSPAKNTRSSGQQDWKRLLKGTRIAELVGSEVSRVGDLIRKKDNFSHSRRSSASSLSEYVDADTKIPTEDDSFFCPAQKVDSDNSKAHQGQLPDFTSSSQTKPLNDKDDVAEDEMTTETQDPDSNMGLTSQDISTSMSLDEITRNWTPRYIPCSGRVSKRDISFARARLLSSGIKALEICRYAESSSTPFADSWLNDPVKYNNIGPYILSTGAAALRTRRTVAEFDERVTAYNKTIMDFTKVKAPPMQSRIRNLEMQISSTLTLRIIPLTTRAETLANELGTKCTLPVKRLENILNKGLRKRSRRIRSMITLLSAIFEWMLMGVFWVVWISVMIWKLIRLLAFGAFRGVRWVLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI64</accession>
    <name>D4DI64_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019093.1">
        <property type="nucleotide sequence ID" value="XM_003019047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI64"/>
    <dbReference type="GeneID" id="9582579"/>
    <dbReference type="KEGG" id="tve:TRV_06872"/>
    <dbReference type="HOGENOM" id="CLU_061830_1_0_1"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="30669" checksum="37854FD578FDC516" modified="2010-05-18" version="1">MAASSSIPSFLLPRGGLSQSSLQYLRTTPRRTLLRHANFSSSSASHAAPTKPRVLEKPDKFRPPSHPARRVVNPNKSPRNYPGPPPTAKEIEDRKTKRYPNMFPPEGTVLFKFLTNKGIHVWISMVSIGVNLSSHTKILTVFEQSVLFSLAYFTWSTNFKRTSPYAHLLPGWSQLFSSPISTISQFFTVMKMHAEHTTVISKEKRKRISDDIDKRKEYRIAHGLEEDDRVKADDAQAAEGAENAVVEGANNVQGVSSEGTAPMRKPKRWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIE4</accession>
    <name>D4DIE4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018941.1">
        <property type="nucleotide sequence ID" value="XM_003018895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIE4"/>
    <dbReference type="GeneID" id="9582099"/>
    <dbReference type="KEGG" id="tve:TRV_06952"/>
    <dbReference type="HOGENOM" id="CLU_120074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF1">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE STCW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="15970" checksum="0A21B2387BE541EF" modified="2010-05-18" version="1">MEAGSYAVKFIRKIQNEDIHSISPRQDVTDAFNEHVQEWTKHTIWADRCRSWYKDYKTGRVNAIWPGSSEHFIELMKQPRFEDYTITYRKKNMWSFLGLGNVPANMTEGVDRSPYLSVDAIDPRWLAAINRERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH3</accession>
    <name>D4DIH3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018970.1">
        <property type="nucleotide sequence ID" value="XM_003018924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIH3"/>
    <dbReference type="GeneID" id="9582131"/>
    <dbReference type="KEGG" id="tve:TRV_06982"/>
    <dbReference type="HOGENOM" id="CLU_832062_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="38271" checksum="9D9E82C62C928A86" modified="2010-05-18" version="1">MANYKPSLGVLNSEKDVHRTDRHIPLFAGEDTPHPDPDSPFAETGTNVHLEQMKDMLLTYNEYNTELGYVQGMSDLLSPIYAVMQDDAIAFWGFVGFMNRMERNFLRDQSGMRQQLLTLDQLLQLMDPKLYLHLQKAESTNFFFFFRMLLVWFKREFEWVDCLRLWEALWTDHLSSNFHIFVALAILEKHRDVIMAHLHHFDEVLKYVNELSNTIDLIPTLSRAEALFHRFEKKVEAIDKKYNFPQAPVRQRTTRPTPQANTTTSPARDSSATATGASPSGGTGAKPSSTPNTKPDSEATSVQIITPDLRKLLSREVEVMDAKEVRQHTLLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIL8</accession>
    <name>D4DIL8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019015.1">
        <property type="nucleotide sequence ID" value="XM_003018969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIL8"/>
    <dbReference type="GeneID" id="9582420"/>
    <dbReference type="KEGG" id="tve:TRV_07028"/>
    <dbReference type="HOGENOM" id="CLU_051898_4_0_1"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="182" mass="20640" checksum="139A64A8B4BB1B07" modified="2010-05-18" version="1">MQPAWLSDINTDSDLLFHVFFLQRYSRLLEESAGRSPAFFSWLLLYATSILLLASPFLSLPFLGSSLSASLVYIWGRKNPDTRLSFLGLLVFTAPYLPFVLMAFSLIVHGTIPKDEICGAVVGHIWYYFTDVYPQMYGGVRPLDPPAWWRRLFESTNTQDQRATNAAHINNDMAAIAARDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIP2</accession>
    <name>D4DIP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018920.1">
        <property type="nucleotide sequence ID" value="XM_003018874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIP2"/>
    <dbReference type="GeneID" id="9582079"/>
    <dbReference type="KEGG" id="tve:TRV_07052"/>
    <dbReference type="HOGENOM" id="CLU_164170_0_0_1"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11385" checksum="8C13B0AA1F3A6431" modified="2010-05-18" version="1">MPVHKVLFWSGFGVAVRLWQLGIEMRPFFNKESLWVYPLFATVGGSFGYWLEGVEGRQLKMLAERKRILLEKRQRRAERDADDTVGLGQAEQGGILASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ24</accession>
    <name>D4DJ24_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018787.1">
        <property type="nucleotide sequence ID" value="XM_003018741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ24"/>
    <dbReference type="GeneID" id="9581184"/>
    <dbReference type="KEGG" id="tve:TRV_07189"/>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="512" mass="56828" checksum="739B5BDC96D056F7" modified="2010-05-18" version="1">MATTAAAPSLQRLDPSIPHTFMRPVKKINDHQDVETFLSSVAYRDIMIFVLQLNRCMFPSKASSESGSSNVEVWTLDSDSVDFSEPVRRLQLLLSKLESLIDEVAPDTGPRRFGNISFRKWCEEMESRAASIMDECLPPEILQRKSEEGETVTAKEELMAYLTGSFGSSQRLDYGTGHELSFLAFLACLWKLNGFAQADPGVEERGIVIGVIEPCVSPFYLTHVPYGSLFLIRYLRLIRRLILTYTLEPAGSHGVWGLDDHSFISYILGSAQLSPPIGPTDPTPTEGSLPNAPATSDVTKSNIVEKERKSNMYFSAIGFIYDVKKGPFWEHSPMLYDISGIKDGWGKINKGMIKMYNAEVLSKFPVVQHFPFGSLFVWKQDPNATSTAPSAHTSSGPQIRTQIPTSPSLSAQSNAGTRAPWASKPTSVEMGDLRGGVPSSHQIPATRAPWASQGGQQRNLPQREPFPPANSSEREVYRGKFYISTTILNRASLNKREVFFIVKKPTLPEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ80</accession>
    <name>D4DJ80_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SacI domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000425">
        <property type="protein sequence ID" value="EFE38096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018741.1">
        <property type="nucleotide sequence ID" value="XM_003018695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ80"/>
    <dbReference type="GeneID" id="9581137"/>
    <dbReference type="KEGG" id="tve:TRV_07246"/>
    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056315" description="SacI domain protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="261"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="4">
        <location>
            <begin position="704"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="107079" checksum="A99F10059749D7D4" modified="2010-05-18" version="1">MPGLARKLLIIAAVDGLILQPYHNNTRSSANLVQVDYKTHHIHSPARVSNYQYKNDACLESHGLIGLLSVASYSFLISITQRQQVAHILGKPIFVITGVSIIPLSGQAEASKAIRQAQRALENSPDAYELSDSESDNSEDFLADEHNNFDAISPEGDLYPPVDEPSNEISIAEDVIKKRGRYGRFTAEWFARKGWGSIGLPDSRRRSLISSSDGSVHAESMELKNLGADALDGLESKETSENTAVTDARTHDLLPKLLKYTKMMFGSRSFYFSYDYDITRRFGPVDPASTHVPLCHQANPLANKPEFQQYFWNRHLMKPFMDSGRHTFTLPIMQGFIGQHEFTAESVMRSSPEGDSQVKYPEESDENTGKASEDASVDGNRNFLLTLISRRSVLRSGVRYLRRGVDDDGNTANSVETEQILSSPSWNPAEKVYSLLQLRGSIPLYFSQSPYYFKPVPIMHHSAQTNLVSFTKHFHDVQRRYGKVHAVCLVDKHGVEVNIAETYGRYLESFNKAETSEDKKVPYQWFDFHAECRGMKFENVSRLVDRMSETLVDFGDTVVQNNAVVRSQSGVIRTNCMDCLDRTGVSQCAFGQWALEKQLKEEGHYIDLQGSAATQWFNILWADNGDAISKQYSSTAALKGDYTRTRKRDYRGALNDLGLTLTRYYTNIFTDYFSQACIDYLLGNVTTRVFDEFETNLQSADPGISMEKARQSAIETSCQIVISDENEEFIGGWTMLSPRQPNTLRTLPFEQTVLLLTNVAVYSCRFDCNTEKVTSFERIDLTSITGIKYGTYISSTLTDAQRDEKRNMGLAIAYRPGTSNSLRVNTTSLHSLFAEKPDPAPENQDIIDWDLSTLFKGSDRSSTHFLAFKLPNTSSAVARAPKTPEVSEADAVRAICEEIERMVNRATQSPSIHAERPSIVEQTQIISLENARRQTGYFEHLFFDIKKLVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJP4</accession>
    <name>D4DJP4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018567.1">
        <property type="nucleotide sequence ID" value="XM_003018521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJP4"/>
    <dbReference type="GeneID" id="9584496"/>
    <dbReference type="KEGG" id="tve:TRV_07412"/>
    <dbReference type="HOGENOM" id="CLU_1628240_0_0_1"/>
    <dbReference type="OrthoDB" id="4169726at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="163" mass="17665" checksum="A009E05ABE015370" modified="2010-05-18" version="1">MPTCPDGLPHHASAGGAAVVGDGKSIITYERMGSKISHLAPHETCHIYMSITNPDSKTAKLKRIQVECEGGNGGKIMGTWIYFGHHHVLEVHVPNVDSDYEIVPSIGHQIPNSQPFGTNVTFVLHLPNHDSFIKIISVALGFGHDHESDPSLEVSETKVLISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJY5</accession>
    <name>D4DJY5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphate transporter (Pho88)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018480.1">
        <property type="nucleotide sequence ID" value="XM_003018434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJY5"/>
    <dbReference type="GeneID" id="9584409"/>
    <dbReference type="KEGG" id="tve:TRV_07493"/>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19567" checksum="A9342B46CD36CFAE" modified="2010-05-18" version="1">MMQVSKKIPFDNPDVLLGVRTMYIASNIAIAALYYYIYTVIVQKKDLKTLKYVEPPAMGSQDEPRPVVTTVQEYDKQQLRAALKSQLMGVGMMAVMHLYFKYTNPLLMQSIIPIKSALESNIVKVHLFNVPAKGDLERPWKAAGGMMGMGQPPVKTDKASVESAEKNWRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK76</accession>
    <name>D4DK76_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018403.1">
        <property type="nucleotide sequence ID" value="XM_003018357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK76"/>
    <dbReference type="GeneID" id="9584321"/>
    <dbReference type="KEGG" id="tve:TRV_07597"/>
    <dbReference type="HOGENOM" id="CLU_013394_0_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF301">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="306"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="484" mass="54472" checksum="BB1C03DE63B4013D" modified="2010-05-18" version="1">MANAFSICSLSQDWRAELGTVGTGNLPKTVKDPSWLAITINSVSLGFALISNLSLLLNMARRVRFSVSQPITIGGWYIASALLVGLTVAVPRVTDLHGRQLTQAYYYAIMAAAIYFFVSSLLLVTVYGANTGRYSKHFHLTTSQRSLMLQTILYMMYLLIGAAIFSRVENWSYLDALYWADFTLLTNGIGDLAPATHLGRSLLFPFAVGGILTLGLVVMSIRSMMIERARTQLTARTTEKTRKLVTEQLQSGDIKKRMLQPLANQDNSLSDKELQQEEFQLMHRIHKTCAWQLRWLSLLISAFAWAILWLVGSVAFWLAERDAGWTYFTSLYFAYVNLLTIGYGDVVLGQSWGKPFFVLWSLLAVPTTTILISSMGDTVAKLFHDATIFAGDLTLFPHETGIKNRLFSFIHGMVESLRHRGRHTEYISGQPISDHPHTYHSASMENLTPQHPEYQDGALRDAALFPRYLPQMRNYPMRKGLAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK83</accession>
    <name>D4DK83_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018410.1">
        <property type="nucleotide sequence ID" value="XM_003018364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK83"/>
    <dbReference type="GeneID" id="9584328"/>
    <dbReference type="KEGG" id="tve:TRV_07604"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_11_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="19554" checksum="43287BBA5D9CACD2" modified="2010-05-18" version="1">MNEEGHTDDIMPDIYRAPEVVMHMRWNVKVDIWSVAMVAWDLVAPHPMFNRQHPETGEPDDRYLIAQFAAILGPPPVEFWSQSKLCQAFWDENGNWKNVVPLPEISLEGLAADIEGEDVPGFLRFLRRILRWLPEQRPTTEELIYDPWLLAGLGSGIQGQIKADKDPLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKA2</accession>
    <name>D4DKA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000457">
        <property type="protein sequence ID" value="EFE37723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018368.1">
        <property type="nucleotide sequence ID" value="XM_003018322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKA2"/>
    <dbReference type="GeneID" id="9584296"/>
    <dbReference type="KEGG" id="tve:TRV_07623"/>
    <dbReference type="HOGENOM" id="CLU_032571_2_2_1"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056336" description="Endoglucanase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25689" checksum="C0E43813BCFFCBBF" modified="2010-05-18" version="1">MRASTFTLYALCAAGSAMAHMEMQWPYALRSKFNKENTNPDWSMTGPLNPSGADFPCKGYHKDPFKSVATYEAGQEYNLTLAGNTRHDGGSCQVSLSYDNGKTFKVINSYLGGCPMKDTYNFNIPANAPSGKALLAWSWFNLAGNREMYMNCAQVTVDSKSASTTQFNSLPDMFVANVGNGCTTVEGQDIVFEDPGKQVQYADGVTAQTQVSPKCPKKSAKRSEKCGGTHSAKFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL12</accession>
    <name>D4DL12_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ABC multidrug transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_07886</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000487">
        <property type="protein sequence ID" value="EFE37465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018110.1">
        <property type="nucleotide sequence ID" value="XM_003018064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL12"/>
    <dbReference type="GeneID" id="9579318"/>
    <dbReference type="KEGG" id="tve:TRV_07886"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_8_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="140"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="383"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="703"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1026"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE37465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1270" mass="138748" checksum="6B42FD76A324A16E" modified="2010-05-18" version="1">MTGELQPVVAVLRDGEGGLDTRAPTEAGSLGEEAPKKETDGIVDVPDAEQQKQEAPQQGFSAYVVSISAANCDIQLCQQQLKIISRNYGLGALPLMTIIFGKFVNIFNDFGVGKISGDDFRAQISKNALWFVYLFIGKFAYIRAILRQEMAYFDTYTPGSVATRISNNANLIQTGMSEKVGTCCQGVAMLIAAFVVAFTQSWRLTLPVATSIPTAVTLVGITVALDAKLEAKILDIYSKAGGLVEETLGSIRVVVAFGAGDRLSKKYDNHLEAAKGFGVKKGPVLGVQYSSEFFIMYCAYALAFWYGIKLLLQGKIGSGGDILTVLFSIVIGTSSLTMIAPTLGEFTKAGAAANDVLNMINRVPEIDSLSTEGLKPSSVKGDLELSNAVFSYPARPTIRVLDGVNLKIPARKVTALVGASGSGKSTIIGLLERWYDPASGSITLDGVDIKDLNVGWLRRQIGLVQQEPVLFNDTIYTNVLYGLPPDEIARMDEEKRRELVRQACIESNADDFIQGFPKGYDTVVGERGSLLSGGQRQRVAIARSIISNPPILLLDEATSALDPTAEAIVQAALDRVSQTRTTVLIAHKLSTVKKADNIIVMNKGQVIEQGTHESLLDTKGQYWSLVNAQSLSLASDDSSSDTDKETDAQPTEILEKHATTKSTHSNVPHEVAAESEDVARKFSLFKCLLIIFYEQRRHWLFFLLGGLASIVGGGAFPAQAILFSRIVTAFQLPRDQWQKEGNFWALMFFVLALCILLTYASIGFFLTVAAFRSSKFYRSEYFKAMISQDIAYFDKPANSSGSLTARLSTDPQNLQDLLSSNIGLILIVIVSLLAVSLLALVTGWRLALVSLFGCLPPLFLAGFIRMRMEMQAQDKNAKLYLESARFASEAVNSIRTVSSLTLEPTVYNNYGDRLKKPVARSLKYTTIAMIFFGFSDSVDTAAMALAFWYGGRLMSYGEYDAQQFFVIFIAVIFGGQAAGFIFGFTMNTTKAHAAANHIIHLRGQVAPINGSTGEEPASTEDSDVAVEFRNVSFSYPTRPDQPVLRKINLKIRHGQNVGLVGPSGCGKTTMIALLERFYDVTSGDILINGKPLTDIDVTKYRETASLVSQETTLYQGTIRENILLGVTRDVPDEEIHQACKDANIHDFIISLPEGYNTEAGSRGLSFSGGQRQRLATARALLRNPDFLFLDEATSALDTESERVVQAALEHAKRGRTTIAVAHRLSTVQDYDAIFVLEAGKIVEQGTHQELLRRKGRYFEMCKAQSLDREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL39</accession>
    <name>D4DL39_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_07913</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018077.1">
        <property type="nucleotide sequence ID" value="XM_003018031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL39"/>
    <dbReference type="GeneID" id="9579286"/>
    <dbReference type="KEGG" id="tve:TRV_07913"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="18">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="17">
        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="401"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="494" mass="55046" checksum="9B0371006F5D0037" modified="2010-05-18" version="1">MAATTGKGDVADYSIKPEAVAPPIPTSEWPLLLKNYDKLLVRTSHFTPIPNGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWMKRMLRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFARALETLSGALFQRPPLISAVKRQLRIRTIYESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDEKDGMVTLHDVLDAQWMMDNHRDESYLRKVIRPLESLLTSYKRIVVKDSAVNAVCYGAKLMIPGLLRFEAGIEIYEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKLKADGKLDKYGRTNASTPAKWQAEYKDYDAQAAGTPNAAPAPGATTPAKSTPAAPAASSPEKEDEEVDDADKKRKRKDGETAEEREERKRLKKEKKEAKEKKKQEKKEKKEKRKSKQAEDASDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLE2</accession>
    <name>D4DLE2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol dehydrogenase ArbD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017965.1">
        <property type="nucleotide sequence ID" value="XM_003017919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLE2"/>
    <dbReference type="GeneID" id="9579843"/>
    <dbReference type="KEGG" id="tve:TRV_08016"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39329" checksum="DC2D4D5A48E4A4B1" modified="2010-05-18" version="1">MFRLSARSSLLRAACGPSSIIRGPSAAATAGRFGVQQAAYRRNISSSTALYKDNEKVPAAAIDAEGGLARTDDSVRVEYPPDDEMPQTPIVQGRGGRHFKRTLASFSLEGRVSVITGGARGLGLVMGQALVASGSDLAIVDLNKQEAELQAKKLLEQFEKENPGLDRLPKITAHYADVGDPESVNASIAEIISKHTKIDHLVTSAGFTENFDAISYPYDRIQKLWKVNVDGSYLFAVEVAKHLMERKAPGSMVLIGSMSGSIVNVPQPQAPYNAAKAAIRHLAASLAVEWAGAGIRVNCISPGYMLTALTQKILDDNPDLNQKWTSLIPQGKMGVPEDLMGAVVFLTSDASKYVTGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLN1</accession>
    <name>D4DLN1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000515">
        <property type="protein sequence ID" value="EFE37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017881.1">
        <property type="nucleotide sequence ID" value="XM_003017835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLN1"/>
    <dbReference type="GeneID" id="9583782"/>
    <dbReference type="KEGG" id="tve:TRV_08105"/>
    <dbReference type="HOGENOM" id="CLU_036615_0_0_1"/>
    <dbReference type="OrthoDB" id="3549121at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="364" mass="38611" checksum="4E83E9D671172B92" modified="2010-05-18" version="1" fragment="single">QQQQQQQQPNGVGGAANGYGAAPGGPPGAPGAPGPATAALPSTNGGLMTPGVNPHAAAAAAAGGMQTPMASLPGRPSLPSQAAPPSAAAPAAAPARAHSTPKAKQARQSTSSLPAPPLDDVHAAFVEFRAKEEDKVGLFFTPFYSIIYPCLSVQCIYCQQVRAKNTSRQRQHLLECPTYLNVMKDSIPANNLQHTFPEGDIARSLQLPAPTLELDFRMSIKLNPSVSLGHSIWGQRDWVTFVGGQWAGRWGKGVVLPGGQDSQVVVKELATSMKSSYLLQTSDEPPAFIMVKANGWMTGAKEVLEKVADPTVADSINPNTYKYRVNISMETGDERYAFVNTIMWVGSGCRRGSEGISLLLFFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLU1</accession>
    <name>D4DLU1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000523">
        <property type="protein sequence ID" value="EFE37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017829.1">
        <property type="nucleotide sequence ID" value="XM_003017783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLU1"/>
    <dbReference type="GeneID" id="9583723"/>
    <dbReference type="KEGG" id="tve:TRV_08165"/>
    <dbReference type="HOGENOM" id="CLU_747972_0_0_1"/>
    <dbReference type="OrthoDB" id="4174374at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="446" mass="50567" checksum="4E460DB9FCDEF2FD" modified="2010-05-18" version="1">MHRATERARRSEDRRHIPADGFISSDAGSYSGSSSEIESIRTASSVAYGEDDEDETLRRAFEESLRLEKDRQRQRREAEWEAMLREEEVRRQSLREARAEARRAQWAARAEEAAIRTAMQASEREQEEARARRIRENLCLFQQTVEQSRRENMAGNVRGSRRNLQRLSRDLPSTIPRPRREQGAEAGRNAGQSTTRELTRLSREERGAQAARPRSHRVRDAMRDAVTRSRAFSFGRSSPEWQDSERAVPPYTASSRPSANTTRASNPTRPSNPTSPSNPVGPAQSPRSRSPVAPAGSGDRRRIANPGHYSMLLVTPVDPTNYRVRDVIRRSRREFHARAAATEAGEGFDSDLQRAINESAEQHRDEEEEAVQRSRGIPTYEEACASVRYRPSPGMRYSFQGPEVIEIPRENGPPTKLSIVGDMDLGEAMRIANQRVKRKRGQAQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYW7</accession>
    <name>D4CYW7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025801.1">
        <property type="nucleotide sequence ID" value="XM_003025755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYW7"/>
    <dbReference type="GeneID" id="9582044"/>
    <dbReference type="KEGG" id="tve:TRV_00004"/>
    <dbReference type="HOGENOM" id="CLU_019094_0_0_1"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="673" mass="74584" checksum="0E9E2F5E3BC68495" modified="2010-05-18" version="1">MAGRCINCHITASSSSSRPGGKKDVRLALLRTQFTFDAYFTVLYIFLFHVAVSSHSCPPSLPDHEREEPSSRWFPFPFSFFFFFFVLLVLLVLLLVFCATMSSTSAPKDDIDIGMPLINTPDSPLTQRVQRGLSEPRSLPSASSQHTPATDLPPVKCTWCGLEFPSGTSESEATTGNSLDSLKQHMRDEHPDIAKDLFNNLVAEENLTPSLESDQGSRLPVASQSEGTPNVEEELERHWTMHDVRNFTEDYEGKRDDIKSRWEGAFDGFERPQPYESASTAPGKFLTLTDPNIYIDIMKDPSTLSTKELYAITVNAAHALRVWQDEHMALEKLIKRATRSSLKKTSNPRELEDPQVFEDKKEAMLYGYKHDPKASQIGYQDPFAQGGFIPTADQMRKMKLSGTEPWKMNRWATVKENGVECVPKLRPPPVIKPKKRAPNVAKAEAEAKALLVPKRVTRYGGSKPSSTGDTSQAPSEPGSPGGPSRSQSRHATPQSSVPTPVRKSTRPLAQALYALSTSAPRSAPVKSPKSPKSPAPTSAGTSKASTPFYPDPLQDPKNQLKIKNSKHPKRTEAMILHWAKFNQEGRTRNPKRTKAQIEAARVAEREASLDPSVASLASRKRTAANSAERTDSHPPSIKKMRRDANGKTEPVTPISEHGEGSSFHYHMHTASHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ45</accession>
    <name>D4CZ45_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025755.1">
        <property type="nucleotide sequence ID" value="XM_003025709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ45"/>
    <dbReference type="GeneID" id="9581986"/>
    <dbReference type="KEGG" id="tve:TRV_00082"/>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="227" mass="25616" checksum="CD7A89B016465AE6" modified="2010-05-18" version="1">MAERILMNEYKSLVKEKWLNIELSNDDIFNWDIALIVLNPDSLYHGGYFKGKITFPRNYPYSPPQFRFTPSLWHPNIYDNGYVCISILHKPGEDEMSGELASERWSPAQRVESVLISIISLLDDAEVSSPANVEAGVQLRSNPAAYKKRVKAEVERSLKDIPDGYEMPTSHEASIAPPTKPVERDEDFWVDSGDEDSFEEMFGGSDSDCELDDDQDTGSEPETGSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZE6</accession>
    <name>D4CZE6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000012">
        <property type="protein sequence ID" value="EFE45026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025637.1">
        <property type="nucleotide sequence ID" value="XM_003025591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZE6"/>
    <dbReference type="GeneID" id="9581874"/>
    <dbReference type="KEGG" id="tve:TRV_00188"/>
    <dbReference type="HOGENOM" id="CLU_886203_0_0_1"/>
    <dbReference type="OrthoDB" id="4173863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055461" evidence="1">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="314" mass="34319" checksum="091CF5BACF7539CB" modified="2010-05-18" version="1">MSCFSITNFVSSLPLLFLFSSSSFPSQPTPAPTRYLPVYRSSVSPSLQHTISHTGQQEYPARMGPQTLGLFLIVLFVATRTSRVMSAPALTARDSPTAGGAATGETNGQIAARWMVYFSPLVGLIISVLSVTVVPKLVLWFKNLGKTGDEIIKSQEEQIETIRRDVSALKSVVDNIKSHVEPNQQNYNDLKTSVDEIKTSINSHLKAVEARLSSINTRLAILGRKCEALKAGQDTIRSTLDNLMQKVKDGEPFRGTTSDSLQKVIEKQDGFKKGLDAFNDSQKRTLETLDRLIEFIPALVGQPANPQVAGQGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZI0</accession>
    <name>D4CZI0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025582.1">
        <property type="nucleotide sequence ID" value="XM_003025536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZI0"/>
    <dbReference type="GeneID" id="9581820"/>
    <dbReference type="KEGG" id="tve:TRV_00222"/>
    <dbReference type="HOGENOM" id="CLU_022194_1_0_1"/>
    <dbReference type="OrthoDB" id="2128708at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056039" description="NodB homology domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="205"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="389" mass="44160" checksum="704453C98CE2380D" modified="2010-05-18" version="1">MGPSNWFQLLASMAISSVILMNANSSLAAPVAKYDPLVIDTFRSPETNDLGFWHGVDEGMPSEYGEDFLRLSPTNADMNFYTQIATSCLDMTAYKDSYLHVVFKGSDKFTISVTQHNAECDQERAPFPETWDSVEASRYSRGGHIYVPLSHFYIDFMRPNSIGFHGFYTRKDVTLFKVEIVSSLPKGIKLPDKLPTGTLALRCKRPNSFAFGIDDGQPQYAQEVMKMIAEENILVTFFTVGNGLLDEAANFTNVYKDMLDRGHQVALHTYSHPMMEGLPTTEKIDEEFKKNMEVFKEKLGIETLVTDPYIINWSVDIEDWLWAGSPTPEKQLEAFKRDLEKGGDIAVMHYLNPTTISYFREVFQLVKKSGRRIMRVDQCMEDPSAPPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZI7</accession>
    <name>D4CZI7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_00229</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025589.1">
        <property type="nucleotide sequence ID" value="XM_003025543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZI7"/>
    <dbReference type="GeneID" id="9581827"/>
    <dbReference type="KEGG" id="tve:TRV_00229"/>
    <dbReference type="HOGENOM" id="CLU_007818_8_1_1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056040" description="chitinase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="21">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="349"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="653"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="356"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="746" mass="78999" checksum="DA09A6B36072C472" modified="2010-05-18" version="1">MALPKTIMAFIAFISLLVSTTFAMDVFSTTNVVTYWGQGHNQKRLSHYCQQVEHDIIVIGFVNVFPDQGKGGWPGTNFGNQCFMGTYITPAGEETELLSSCHKIIEDIPICKAAGKTIMLSLGGQAVDGSKTYSVKTRESAVYFADFLWRAFGPVSPEWDGPRPFGDNVIDGFDFDIEANGGANYEYMVERLRSNFATDSSRQYYLSAAPQCVLPDGNLGNVISSSAFDFIFVQFYNTPSCSAFNWAQNPSKSGFTFDSWVQFIRKGASRNAKLFIGLVGDHTRVSPHGEYTKDDSNYLALPDADKLIKAYMNKYRANFGGVMIWDALTSDENKLVTGTYASNIKRLLLNNDPSRPTTTSKAMSSTKTSMPTTTSISTATTSTISSTSKISSSTGPIPTMTTSTRNTSSTATRSSTMATPSTSPSPTSSTSTTSGHQNTTATTTETETQTSKTFITTTSIWSSGTGIGTGTGIPTITTTPRYPNTTFTSDTTGSPTMSDTTITLTTTSSMHQSSDTTVTIPTFTTTPVQTSDISISMPSGITTSSKHQSSEITIPGPPHMSTTIVSPSPTKPGHSTTTAIVTTTFTSVCPTGITTVTTTYTTIYCPEATPMPTAGNSSPPPGMEWTTIVTTCTKCSSTSAIMTVTYPVTVPSEPVTPTQVPGTLPPPGAPGTGSGIPPPKTPNNEPGSPGTLTGIFPPKPTMSVPPEMGGDGGDTTPVYTGGAGVVSPSFSVVVMILGAIVYHIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZX5</accession>
    <name>D4CZX5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase family T4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025429.1">
        <property type="nucleotide sequence ID" value="XM_003025383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZX5"/>
    <dbReference type="MEROPS" id="P01.003"/>
    <dbReference type="GeneID" id="9581685"/>
    <dbReference type="KEGG" id="tve:TRV_00369"/>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_1"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42353" checksum="A228AFB9CD991F87" modified="2010-05-18" version="1">MPILSAGFSLKATILIIPRYLRAHNVSPVFYNICTTQVRCSRILSQWPNNHPRHRGCVSENFYQLFISVTSLPARSTLTDVPGVKVNTQEVHGDDGAINTGVTCILPRDNWSEEFCYAGPFSFNSAGELTGANVVNETGLLISPIVLTGTLEIVKPEHVVAGLENASAERVKEGNTGGGTGMICHRFKAGTGSSSRVVPRGDGKPGVKGYTIGALVQTNYGKMKDLRIGGVPIGRILAADAAKDEARKAALEDLAREKDRKDGSIIVVLATDAPLHPLQLQRIAKRATVGLARVGGNGHNTSGDIFLAFSTGNSIPNMDVLGPRKGPTPLAIEVIDDKTIDNLFDATADVTEEAIYNALCMAETMTGYLGRKVEALPLDRVKEIVTKSDVSSEYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D017</accession>
    <name>D4D017_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025421.1">
        <property type="nucleotide sequence ID" value="XM_003025375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D017"/>
    <dbReference type="GeneID" id="9581657"/>
    <dbReference type="KEGG" id="tve:TRV_00411"/>
    <dbReference type="HOGENOM" id="CLU_2591508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="80" mass="9760" checksum="F564A0D9B632BC98" modified="2010-05-18" version="1">MKGWEKKRKDSRHLTNWQRRRKNARCTHKKDILINEPPFAITMQVDKKKKMNEMEVDIKSEETKARQPNTKIKRKGRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D061</accession>
    <name>D4D061_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025394.1">
        <property type="nucleotide sequence ID" value="XM_003025348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D061"/>
    <dbReference type="GeneID" id="9581630"/>
    <dbReference type="KEGG" id="tve:TRV_00455"/>
    <dbReference type="HOGENOM" id="CLU_032571_2_2_1"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055136" description="Endoglucanase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28344" checksum="706497F93001230B" modified="2010-05-18" version="1">MSIMNTVALVGLLATSATAHMMLHYPPTFGAENNPHRTDPVDPYLDNPYNCCGRKTVYPCRGYLDLLGTDQGRPVVSWEAGSSQSFSLTGRGTHWGGSCQAGFSTDQGKTWRVVRSYEGNCPHREGSNQNPEEQTFDFKIPSDMPTGDHVFAWTWFNREQEFFMTCASVTITESGNGGNTSQPRAFVPRGSSARPTPDDDKSSSVPFDQLPDFLVANTDNGCMTPRTNAEVKYPNPGPDVAKGDGAYPLELPSPMDKCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D064</accession>
    <name>D4D064_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025397.1">
        <property type="nucleotide sequence ID" value="XM_003025351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D064"/>
    <dbReference type="GeneID" id="9581633"/>
    <dbReference type="KEGG" id="tve:TRV_00458"/>
    <dbReference type="HOGENOM" id="CLU_1620262_0_0_1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18172" checksum="13A6686054B72F89" modified="2010-05-18" version="1">MESQGISRGEPRRQTYTVRRIKPSDFPAAAEILANDSSLGKTLHSGKEAHHSDPVDGFIQSIRSRYLSPGWVIYVAVAVPSRDDTTGLNEIIVGYAAWKRTGTSPAAQAWSDNNEWKLNGMNALLLFSCGWMAGSRKRLRLRSPGIPFQLTRQSNPMLSVKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0D6</accession>
    <name>D4D0D6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000029">
        <property type="protein sequence ID" value="EFE44681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025292.1">
        <property type="nucleotide sequence ID" value="XM_003025246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0D6"/>
    <dbReference type="GeneID" id="9582903"/>
    <dbReference type="KEGG" id="tve:TRV_00531"/>
    <dbReference type="HOGENOM" id="CLU_1723651_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="16960" checksum="D872E4F13ADF3DA2" modified="2010-05-18" version="1">MEVDLVNYENLSGGYPDTHPTGTMEHWNSDELTSTEGVETSFAKADDIMKNDLPYHCAFNKKATMAISPRYTDIYASPTDTYISPQNASPESLSSHPDLGKREEFVSSDIPVDDEFTVRPPSSTHVSFALVLLTLCDLFPFCLSFHTKIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0G8</accession>
    <name>D4D0G8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025247.1">
        <property type="nucleotide sequence ID" value="XM_003025201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0G8"/>
    <dbReference type="GeneID" id="9580739"/>
    <dbReference type="KEGG" id="tve:TRV_00563"/>
    <dbReference type="HOGENOM" id="CLU_029404_7_2_1"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="428" mass="46578" checksum="5F2F35962180DE12" modified="2010-05-18" version="1">MATVALSSRAASCLVQVPRYGLYNINILPQRTPRVCVTTARRKYNGGRREFSSGSPLESRPKISFRLAVSSSGKGRRFSPDRNFYNFHPQVHDALGIQSPNYYDRKANRPDSGEDSFFISKIGYDNEAFAFGVADGVGGWSESGIDPADFSHSFCGHMAETALNWESSPESLRAMTLMRLGYEKTLLDKAVFAGSSTACIGVARNDGSVQLANLGDSGSLLFRLAAVHHYSVPQTHDFNTPYQLAAVPELIRRQSYLFGGKQFEDMPQDAAVTNCSLQHGDVLVLATDGVFDNLNNQEVLKLVTARMMATGAWTGTSDMGISASDNLEALTKPGGLKFGNNRIKPKKAIAASEEADPQGKGHTLQALLAVTIAGEAKIASMDFRRDGPFAKEYQRYRPWDHYRGGKPDDITVVALVAVEEGRSSASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0S2</accession>
    <name>D4D0S2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025142.1">
        <property type="nucleotide sequence ID" value="XM_003025096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0S2"/>
    <dbReference type="GeneID" id="9580635"/>
    <dbReference type="KEGG" id="tve:TRV_00667"/>
    <dbReference type="HOGENOM" id="CLU_057180_0_1_1"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30069" checksum="48D2EDC1A0213768" modified="2010-05-18" version="1">MLLIGLTGSIATGKSTVSSLLSSPPYNIPIIDADVLARKVVEPGTAGYRAIVDYFEPTTPDLLLPEEQPGKGRPLNRPVLGRRVFGDSPERKKDRSVLNGIVHPAVRWEMYRALLWYYIHGHWAVVLDVPLLFESGLDALCGTVIVVGVKDPAVQMQRLRARDPHLSAEDAENRVRSQGDVQGKVERAEFRGTENARGVIVWNDGDKSELEVEVRRAITHISSTSPQWWAWVLLLVPPLGVGVAAWNLARNYREKARWEEKQRSDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Z3</accession>
    <name>D4D0Z3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025081.1">
        <property type="nucleotide sequence ID" value="XM_003025035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Z3"/>
    <dbReference type="GeneID" id="9580561"/>
    <dbReference type="KEGG" id="tve:TRV_00739"/>
    <dbReference type="HOGENOM" id="CLU_058677_2_0_1"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="332" mass="35397" checksum="428C1ADCEDF4B44B" modified="2010-05-18" version="1">MSNGAHMSNSPPTTPIAPRGRRASITEMFARPGNAAPPPLNTNTSSTTAPLFTAAASNAQQQPHRRRMSITTLGLSGSPTNQSAPFGQTAATATPTAAAGTTVPPPNGRRRRGSVSSSILSSSPTRDQAVVEEEDEEDTPMPTSPPPFARRVSFSFRDRAASLNGIYQSLSIPDKHSIPSFKQLIITPSIYCRGGSLGEGFNWPEALRSRAERAPSLAGSFSMHQQQQGQGHGQGQQHPSSVSGSSTSNTSPSSSPSLSSSFSSASFPGKHHRSASVATMEAYKPPPKELLERHPSSPPPPSQQQKPPQQQPKPRPKPDYFQEKILRADFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K2</accession>
    <name>D4D1K2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_00953</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024878.1">
        <property type="nucleotide sequence ID" value="XM_003024832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K2"/>
    <dbReference type="GeneID" id="9580369"/>
    <dbReference type="KEGG" id="tve:TRV_00953"/>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000008">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="11">
        <location>
            <begin position="15"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="D-3-phosphoglycerate dehydrogenase ASB" evidence="13">
        <location>
            <begin position="338"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="571" mass="59940" checksum="1F14C3F2DD2FFA7A" modified="2010-05-18" version="1">MAAPVTNGLPPRPKVLVPEKLSPDGLALLKSSLDVDERQGLTADELLGIIPEYEALLVRSATKVTASVLQAASKLKVVARAGVGVDNIDADAATKQGIVVVNSPSGNNVAAAEHTIALLMCMARNIPDACSSLKSNKWERSRLVGVEVQGKTLGIIGLGKVGLIVARLAKGLGMNVNAVDPYASSAVAASASVTLMPSLAELLPTVDFLTIHTPLIASTKGMISSAELAQMKPGSRILNVARGGTIDEPALLNALETGHIAGAALDVFATEPPTSGSASAQLIAHPRVIPTPHLGASTVEAQENVSIDVCEQVLQILGGSLPRSAVNAPLILPEEYKKLQPYVHLVEKIGSIYTQHYGSAKSPLSNRNTFDLIYEGEVSEMNNTKPLFAALIKGLMSPISKDLNVNIVNAELVARERGIVVNEQRSRDSPSHSYSSLITLVARAAKVNGDSLGSSHQHDYIISGTCSESQPLISRIDRFATSFVPEGTLLICHNFDSPGKIGVVGSILGKRGVNLNFMSVAPISKGKKQQKEIDSSDEALMILGVDRTVDECVVKALVNEGGVLSASVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Q7</accession>
    <name>D4D1Q7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024835.1">
        <property type="nucleotide sequence ID" value="XM_003024789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Q7"/>
    <dbReference type="GeneID" id="9580313"/>
    <dbReference type="KEGG" id="tve:TRV_01000"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="146"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="416" mass="46203" checksum="93E25F7C527BA730" modified="2010-05-18" version="1">MASNGARRWQQLFQELILIAGTSLSTYFVVRFLLSKLELDPDSQKREEAKRKSAAVLKRLDREEDSDNDSSGSEKKNGKRRQRKEKLVLTQYEQTIAMDVVAPEDIPVTFEDIGGLDEIIEELKESVIYPLTMPQLYRTTSSLLSAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTLTEKWYGDSNKLVNAVFSLARKLEPSIVFIDEIDAVLGTRRSGEHEASGMVKAEFMTHWDGLTSANAMGQPQRVLILGATNRIQDIDEAILRRMPKKFPVTLPLAAQRRRILNIVLKDTKLDKDNFDLSYLVNVMDGMSGSDIKEACRDAAMVPVRELIREKRDAGAMIHSVNPEEARGVRTTDFFKKAGAVKSSIHSTTSLRKSLSEKDWSTESGQDEMVDASAIIPVAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1S4</accession>
    <name>D4D1S4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000058">
        <property type="protein sequence ID" value="EFE44199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024810.1">
        <property type="nucleotide sequence ID" value="XM_003024764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1S4"/>
    <dbReference type="GeneID" id="9580300"/>
    <dbReference type="KEGG" id="tve:TRV_01026"/>
    <dbReference type="HOGENOM" id="CLU_017851_0_0_1"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="672" mass="75084" checksum="53BEDA2F9F1627FC" modified="2010-05-18" version="1">MARFSLPSPAFDFFQPPPNLDTKPMFARDEEMSVLDDKILDTSAQDMSMDSSRRTSFDQATDEFSRRESVWSDMAQHQTDAQSRHPSQLSTPLFEPVSNPFVRLDAPTGAFAQQQHPHHQHHQQQQPLWPVSNESGSCTPTPIYENFPQEFDGAVANPFTGGAVGQVQPMSYQQMQFRASPPFAAPNSIPMSPQSSQGWVSGSSEVPEVQSRPVRTSGGYRNSAASLTIRRDGIRKKNARFDIPAERTLSNIDLLISQSNDEDEIKELKQQKRLLRNRQAALDSRQRKKVHTEQLEEDKRRSSTHINELQEALQEMKLREAELIREKNEMLERQQQLHQFVEQLHMEKEELIRTHTLETGELRKKNTILREHLERMEMNSSNPSDSGSTVRNDFSDYGGLNMDNPSWESFSLSDEFSLDTEQRPQPRSPTPTPARHPFTLDFSSKKTEKQAEKPLTQSDSAFSWNAFYMCLLFGAFIASNSTSTSQPAIPALSEEYRAESANVLRAVLASGSPEGNSASIVGPSPSSSALLPTTISNSEMAQITSGPTGGAATNLDVLHNNLVAPSKEQEDAQAFAMTTKQYQALTTLGDDEMGEDHVAPPSNLQQAYAAMRNNGLQNRAAFKGNGNPDIYSRSLMWDRVPQKVLQDFNNMVRECAGKTVKAEEPGRESATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1V6</accession>
    <name>D4D1V6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024776.1">
        <property type="nucleotide sequence ID" value="XM_003024730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1V6"/>
    <dbReference type="GeneID" id="9580266"/>
    <dbReference type="KEGG" id="tve:TRV_01058"/>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="116" mass="13904" checksum="D2416823F0BEF7E9" modified="2010-05-18" version="1">MDIEMSRRNKKPRLLLDSEKQKLEEFVDSIHYSARWANTPPRLLAESPMLTGYMTRYSDNEYEYRHVQLPKPMLKKIPTEYFDHSKGTLKLLWEEEWRGLGITQVRATATWTEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B4</accession>
    <name>D4D2B4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024648.1">
        <property type="nucleotide sequence ID" value="XM_003024602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B4"/>
    <dbReference type="GeneID" id="9582823"/>
    <dbReference type="KEGG" id="tve:TRV_01217"/>
    <dbReference type="HOGENOM" id="CLU_041826_0_0_1"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="504" mass="56143" checksum="7FD87B775861D7A8" modified="2010-05-18" version="1">MVEPKRTYAGGSFCNSARIYEIQASIHRASKVFPFLLFLTGPGLVRSRRVVGGRSSILYIYTLAARRPLSLLSPSPSASFISTSARTEEEVPTSFALPPTSTSLLTFFFFFQIYLTSSSSIFFIIYFILSFFCLSFLFFFALDLLLYNRTIIYKNLDPATDLLPASAAAFAPRASPTVVLSRVEQWMTVTLKRVNKVKRPLNNVGQHTRCLTEILSHQNAIWNLCSIMLPKAPESKLPKDENPLVDALFNYQLAHMEAYVVHVDMVSQNEVAFKLTPETIETLIDHHKEIYSVDTASKTWDWPEKEIQLKKLQEEFVQAVNRFVYRTSASALEGMEEEGAGELLCGLADEAKAAIMGLFVPLLPPPPRIVDVVRSTPLVPSSTGPDDWWHHSPTQQSPSPVDSWDVLPSSPSTTTSDSHPNMWPNIGYNDMSLSSPPASHCQPFSAAAFTTSEFYECPTTLASAVPYLLPDMLVQHQCGTAAGMDGFVWADRYPEFALQYGTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2D4</accession>
    <name>D4D2D4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_01239</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000067">
        <property type="protein sequence ID" value="EFE43989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024600.1">
        <property type="nucleotide sequence ID" value="XM_003024554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2D4"/>
    <dbReference type="GeneID" id="9579923"/>
    <dbReference type="KEGG" id="tve:TRV_01239"/>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="75"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="22">
        <location>
            <begin position="521"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE43989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="657" mass="73040" checksum="F0AB2A3AAE74BAE1" modified="2010-05-18" version="1">MSVLEKIGSMASMAVAGPAAVAIFAYLNAKLAISHDLGLITRYVRALIRGALKDRSNKWNHFYLLEEFALDPKKAKEVFIVYQGKEWTYRQTYDIALRYGNWFRNVHNVKAGEVVAMDFMNSATFVFVWMGLWSIGALPAFINYNLTAAPLAHCVKVSTARLLLVDSEVRHAVPPEMVEKLGAPDFREKGGAVEVVFHDESLQAKILQREPWRAPDTDRQGQARSDAGILIYTSGTTGMPKAAILPWAKLLLAGTFVSKWLGFSKSDRVYTCMPLYHSTAAVLGFFACLASGTTLCIGHKFSASHFWDDVRGSNATIVQYVGETMRYLLATPAQKDPETGEDLDKKHNVRLAYGNGLRPDVWDKVKERFGIPTIGELYSATESTSGLWNLSSNSFTARSIGRSGLIADLILGTSAAIVKLDHDTELPWRDPKTGLCHRVPRGEPGELLYALDAANIKDKFQGYFNNPNASNTKVLRDVLKKGDAWFRTGDVIRYDAEGRWYFSDRIGDTFRWRGENVSTNEVAEVLGSHPQVHETNVYGVLLPHHEGRAGCAALIMEGVDPDAEKLEPSAAFLSSLGEHVTANLPKYAAPLFLRITRALETTGNNKQQKTSLRAEGVDPNVLESKNSKDLLYWLRGKTYVPFEKKDWEKLNAGQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2E7</accession>
    <name>D4D2E7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024540.1">
        <property type="nucleotide sequence ID" value="XM_003024494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2E7"/>
    <dbReference type="GeneID" id="9579763"/>
    <dbReference type="KEGG" id="tve:TRV_01252"/>
    <dbReference type="HOGENOM" id="CLU_009666_3_1_1"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000291">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="563"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="783" mass="84840" checksum="8015FC8D690D887C" modified="2010-05-18" version="1">MASSAGNEGHIYSATYSNVGFFSSSSSSPPPPPLPVPVYEYKLGTENVMRRRVDDWVNATHILKAAGLDKPSRTRILERDVQRGVHEKIQGGYGKYQGTWIPLAEARALADKNNVLDKLRPLFDFMTGDTSPPPAPKHSTAASKPRTRGGGAGSRRGAAGSTRGSFSAVGHHMPPVPPAAPPANSAPASFNQEPQQHQHQHQQYGVSQSFNETSSIMQGSPEASSLIADEDLAQMSPESTQSRKRKRGDNDVAMSIIEQNHILYGDQLLDYFMTVGDDPSASRVLPPVPPTHFQVDRPIDDQGNTALHWACAMGDIDIVKDLISRGADVRVRSKHDETPLVRAVLFTNNYEKRTMGELADLLHSTITFRDWFGATVFNHLAATTRSKGKWKSSRYYCQTLIDKLSQVFPRHEISLLLSSQDANGDTAALTAAKNGCYRLATTLLAQCPEAGDLQNRHHETANEVLMALYKRRKENPPPPSSVTYAQDMDGDVDFAATTPTAGNYTGSAVATEATNALLVRIGSIMAEANRRLARAYGEAKTPPHSSGTGPGGGEDMTNPKGLYEQLEADRENIRSQIEALQAKEEESEDLDAQLARFNEIKARYESLLNQTHDLELTSLYESNGITEDAGDSDANHELAPEEMLELYTLANELAQAQADRDEAVAQLIRQRADAGVSTKLDVHRKLVSLATGLAEEELDPMSSELADALEFDRANEKRSGPAPNTARQLMATGEPDPESPGTRSRSVSQNGHDGIGGGGNSNANETTNGLDNDHAVDASSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2S1</accession>
    <name>D4D2S1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_01377</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024414.1">
        <property type="nucleotide sequence ID" value="XM_003024368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579636"/>
    <dbReference type="KEGG" id="tve:TRV_01377"/>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="771"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1513" mass="166545" checksum="3237F71AF5BFE5E4" modified="2010-05-18" version="1">MAGITTAAEAVARVAYLSSDVVLSVQPTKETDSVFSGTLSRLAQQQVKNVLSDAVPEQGQTVSVTTTSTVLLAAIPHLYRLANYSIVIHVHLEPSQFADYSVISSIRQCGFSFLHSETLQEAHDIGLTAHALALTSGKGVIHFFDLRISEKDQPVVAEDAAFVKDILEISPVRATHTPVDVPQTIYADSGRVAIVTDQGFGGPVINPADASASADTSLPIPSPKSAAPSVDPSSVGSSRRGSILDSHVPSSSATTAETITTRPVDAADIFQIVSIIWDAFSARVGRNYHAIEYSGPQNAKLALFIFGSTGVFLDTLNNPAHKDEFKDVGIITARLYRPWIGSQILRAIPDSVERIAVLEQVRKTTRWGPSFLDLLSSVSQPPSSTRPTPTLVGYRLGYIESATASQAVRGVIQNLTLEAPVQNLDIGTETIPQPDTQLQQPSHENAYTKILKQLFSDRLYIANQLGSQNAGISATIAASPEYGFGSLLARKERRVNLKKDVEEAVKANGFANETSKQLLSKWALNESNSAKVNQIAPDVIDALTADGSGPAEDLLQSKELFFKESQWLIGSDAWAYDLGNSGVHHVLASNENVNMLIIDSQPYSQRTAADPTRRKKDIGLYAMNFGHAYVASVAVYSSYTQVLQAIAEAEQFNGPSVVVAYLPYHKESDSPLTVLQETKKAVEAGYWPLYRWNPENAEKGLPNFSLDSERIRRELEEFLRRDNQLTQLMSREPKFAASLSESYGSEVRALKKRAAKKAYDQLMEGLLGAPLTILFASDNGNGENLAKRLGNRGKARGLKTMVMAMDDYPIEDLSTEENIVLITSTAGQGELPQNGRGFWETVKNAGDLDLSAIKYSVFGLGDSHYWPRKEDKLYYNKPAKDLDARLAFLGGKKLADIGLGDDQDPDGYQTGYSEWEPKIWKALGVDNVEGLPDEPAPLTNEDIKIQSNYLRGTIAEGLRDESTGALAESDLQLTKFHGTYMQDDRDLREERKAQGLEPKYSFMIRCRLAGGVATPSQWLQMDEISSAQGNETMKLTTRQTFQFHGVVKGKLRAAMQAINRALMSTIAACGDVNRNVMCSSLPELSTYHSEVHAVSKLISDHLLPATTAYHEIWLKDENDNKVQVAGDAVVDHEPLYGPTYLPRKFKITIAIPPHNDTDVYAHDIGLIAIKGADGHLEGFNVLVGGGMGVTHNNKKTYPRTGSMLGYVPAKQAHIVCEKIMLVQRDHGDRKNRKHARMKYTVDDMGVDVFKGKVEALLPEDLRFAEPRPFKFDSNVDTFGWIKDEKGLNHFTCFIENGRVEDTSDFLMRTGLREIAKLNKGEFRLTGNQHVIISNIKDEDLPQIKALMAKYKLDNTSFSGLRLSSSACVAFPTCGLAMAESERYLPILITKVESYLEENGLSRESIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRSSIKEAEILDIMKGLLKRYALERQTDGDQPERFGDWCIRAGIIKETTEGKNFHEGVAEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2T3</accession>
    <name>D4D2T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024426.1">
        <property type="nucleotide sequence ID" value="XM_003024380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2T3"/>
    <dbReference type="GeneID" id="9579648"/>
    <dbReference type="KEGG" id="tve:TRV_01389"/>
    <dbReference type="HOGENOM" id="CLU_2401270_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10351" checksum="93487321145F735A" modified="2010-05-18" version="1">MDGQRNARQPAQADFNNCLLTGLVDLSTSFRGCWFNSVVFLIHLPELTALIRILVFAHLFSSVSSSSSSSSCLFVFFVSLFFLSRAEKKPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V1</accession>
    <name>D4D2V1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_01407</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024444.1">
        <property type="nucleotide sequence ID" value="XM_003024398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V1"/>
    <dbReference type="GeneID" id="9579666"/>
    <dbReference type="KEGG" id="tve:TRV_01407"/>
    <dbReference type="HOGENOM" id="CLU_056971_0_0_1"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="95"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="35496" checksum="03F819F673B5D803" modified="2010-05-18" version="1">MTDPNGTSQANGADKSLTETALHGAKQLSKETTDILEPPTLPPLSTVTRNLHNQITAFLAEDHDPSSLLYRVQQQTRISLDVIRESLTRYPIHELSISYNGGKDCLVLLLLFLASLHRHCASTSPSCSSSIASNQSHSSNSPPSHPTYIPAIYAQPKHPFPSVEQFVTQSSQAYHLKLTRHSTDPPHSTIRSTFAEYLSSNPQVRAIFVGTRRTDPHGSKLTHFDRTDHGWPDFMRIHPIIDWHYVEIWAFIKHLGIDYCPLYDQGYTSLGGTNDTHPNPKLKVEGTVENGGLNNHVVTYKPAYELIEDEEERLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D311</accession>
    <name>D4D311_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024401.1">
        <property type="nucleotide sequence ID" value="XM_003024355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D311"/>
    <dbReference type="GeneID" id="9579623"/>
    <dbReference type="KEGG" id="tve:TRV_01468"/>
    <dbReference type="HOGENOM" id="CLU_047036_1_0_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="122"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="29531" checksum="1652E0B89ED72447" modified="2010-05-18" version="1">MDTVYPKIEAGWASLVSSYSPTTIEFVGTSLVQLVAFWIPSAIYLSLDKWAPAFSQKHKIQPAPKQPTAKEIWHCFFYVLKNQLLSTSLHILLLTLVHKNIIPPSYQVLPTLPPFAIVARDFVLSILMREALFYYAHRLLHYPYFYVRIHKRHHKFTAPVALAAQYAHPLEQIGANVLPITLPPQILNSHIITFWLFMGYELFNTATVHSGYDFLSGKAKMHDLHHEKFNLNYGSIGFLDWFHGTDRLRSKEKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3D5</accession>
    <name>D4D3D5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024244.1">
        <property type="nucleotide sequence ID" value="XM_003024198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3D5"/>
    <dbReference type="GeneID" id="9579364"/>
    <dbReference type="KEGG" id="tve:TRV_01595"/>
    <dbReference type="HOGENOM" id="CLU_2074848_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="118" mass="13615" checksum="064AE63489F5B101" modified="2010-05-18" version="1">MADGCTEYGVASQRAGRLPGEADWRQFHRQTPTRQAPLLQLCTSSSTSPQSSLFFSILSFFFFFIFASSASFLISKKKSREKKKKKNRRKIEEEKMKRRKGRRREVHAIISRPVSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3K6</accession>
    <name>D4D3K6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024167.1">
        <property type="nucleotide sequence ID" value="XM_003024121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3K6"/>
    <dbReference type="GeneID" id="9579205"/>
    <dbReference type="KEGG" id="tve:TRV_01666"/>
    <dbReference type="HOGENOM" id="CLU_034574_1_0_1"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="321" mass="35235" checksum="644FC5DD082FDDCF" modified="2010-05-18" version="1">MGKGGRFACIFLPYILSIGTLVCLALVGLGCYNTNTLTDVYFAKVNMKDINTSPSGLNSQLQPLAHGLEQAKAKGDIHDFYIVGMWNYCYGDSKDGSDKVTFCSPRRMRFWFNPAEVWGVDDTIQQLYPSSLQRGLNTYQKVAGWIYVAYAVAISASAIQLLVGISAIFSRWGSFFTTLIAGAKKKLTIFHQVAAVFTIGGAATASVLYGILVGAIKAGLRPFDIKADVGTRMLAIYWLGGLFTLAGGFFWLLSVCCCSGRSPYGHRDDRRGITAEKAPYTYERVASPYGVHPGSAVPMHNMPPHHTQDTAYEPFRHDHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Q1</accession>
    <name>D4D3Q1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000087">
        <property type="protein sequence ID" value="EFE43520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024131.1">
        <property type="nucleotide sequence ID" value="XM_003024085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Q1"/>
    <dbReference type="GeneID" id="9577129"/>
    <dbReference type="KEGG" id="tve:TRV_01711"/>
    <dbReference type="HOGENOM" id="CLU_040048_0_0_1"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="371" mass="41341" checksum="93474E3C173C4255" modified="2010-05-18" version="1" fragment="single">HRRAMTLLPEGPEETPAEQSPGLSDEYLIANLAHRPLHQLAGRISISNPAKFSALLPCEGPSSMGYLDCLPLEILQAILNLLDFQALSRLSCTSHRARRAVEYLPAYRELMEHAPDTLTALGKSCLITAHSAAKLRAALRTESCVWCGEYGPFLFLPTCERCCYECQRSNPSLWVMTADLAKYCFRITAAKLREIPIMRSIYGVYDVSHELSRRRRLKLVSVRVAKELSLTVNAGSAPSNMRNNAHLIHLAHFLNAPLAPEGQNNGSGVTSRIRYCTLTDECCGMGSICFPSLQPDNTVERGLWCRGCFRASEQYRFSSPTADLTTRNVYPLRALIGTNLCARSKMQFLEHIKHCDGSLELQANLRKGLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3T5</accession>
    <name>D4D3T5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000092">
        <property type="protein sequence ID" value="EFE43485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024103.1">
        <property type="nucleotide sequence ID" value="XM_003024057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3T5"/>
    <dbReference type="GeneID" id="9577090"/>
    <dbReference type="KEGG" id="tve:TRV_01747"/>
    <dbReference type="HOGENOM" id="CLU_064985_0_2_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="77"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="27532" checksum="9DB9210D4404AA29" modified="2010-05-18" version="1">MAVDYRHGVAIFSLIVYLPCFFIAVYIALRHGFAKSAGWYFLVVLSLVRVIGSCLELATIANPTEGLIKGAAALNRGRKGIPPIIFRVVGLLVLLGLILSIIGINSQEDGATSYKPNAKSKAAICVTLGVWVITVGLAFIINSNKHSLPAGEKRLLLAVAISLPFILIRLLYSLISAFSHSRRFSAVSGNVTIYLVMAVLEEMVVVITCLGVGITLQPDGVAAYRGEPASAEEEMKVFQEARDNGYRQSVPAPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3X8</accession>
    <name>D4D3X8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD binding Rossmann fold oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024024.1">
        <property type="nucleotide sequence ID" value="XM_003023978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3X8"/>
    <dbReference type="GeneID" id="9582717"/>
    <dbReference type="KEGG" id="tve:TRV_01791"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_2_1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="395" mass="43716" checksum="7E1985B14EFBEB58" modified="2010-05-18" version="1">MAAKAFNVGVIGYGMSAKVFHIPFISALPEFNLYAIVQRTPSASDDAQKDHPESKVYRSAEELVNDSAVDVVVITTTPDSHFSLAKLALEAKKHGTVYSPSIKACPSGHPANRCVRYIVVVEKPFTPTTKEANELIELAKTQNKLLTVYQNRRWDADFVTASKLIKDGSLGRVVEFETHFDRHRPELNIKKAWKGKDIPGGGSIYDLGTHLIDQAVHLFGLPNEITGFITAQREISTENYEDSFTVLLHYDRLLVTAKSGVISPEENQLRFWIRGEKGSFKKYHLDPQEDQLQAGVKLDDAQYGCEPSDRHVSYSISKLTSTLGVLTTFAGGKFSSQTVRPEPPTYKEFYRSLAKALSGQGQVPVDPADSGTVIRLVELAKESSKKRSTLPVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Y6</accession>
    <name>D4D3Y6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024032.1">
        <property type="nucleotide sequence ID" value="XM_003023986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Y6"/>
    <dbReference type="GeneID" id="9582725"/>
    <dbReference type="KEGG" id="tve:TRV_01799"/>
    <dbReference type="HOGENOM" id="CLU_028982_0_0_1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="163"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="294"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="587" mass="64824" checksum="74C2AFD0F611ABA4" modified="2010-05-18" version="1">MDYSSITNDPDPTDSSPWGSTSPRAARPFSASSDVPPAFPSQHQSPYTTDQEGPYQHNDEGGERVHSPGVSDHPADSHPVGSPEAQAAYRHDSQHQQEYRQQQQRSQAPSRYQTGARQQARPNAPKYKLQAKVTALERTGKRDPVIRFDVHTNIPKFRTTQFRDVRRTHSEFIKLGDHLISSNPEALVPAVPPPLTPAGAGTEEDEVRVKASMQRWLNYVCSNDVLMVDDEMILFVESDSGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELHDARPVVKLFYLGTMEAGQKVDRVVKARRALALAESDLGVKLGQMHVQETHAGLANAYKKLGKIIQTTGDYHAAQGTAEATTLGDPLNYHSSDAFIVKETLTNRHILLRELIQAQQTASSKRAAADRLKASTSVRPDKVDEAISALDDARGHEEYLLKKTQRVTNNLLQEKRRWFNRTANDLLLSLREYTLREIEAERRTLSTLESVRADIRSIDSSGGLSRLGRESHPAARRASLASSQGPKGDAWSGVARRGDSLSRSISGSFVAPVPEVDDDVNGTIHGTGRRSRSGTIMEEDDDRVDAKNAASRLAASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D479</accession>
    <name>D4D479_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_01893</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023952.1">
        <property type="nucleotide sequence ID" value="XM_003023906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D479"/>
    <dbReference type="GeneID" id="9582645"/>
    <dbReference type="KEGG" id="tve:TRV_01893"/>
    <dbReference type="HOGENOM" id="CLU_013424_1_1_1"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055969" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="55"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="440"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="634" mass="72787" checksum="561CCF5A6C12312B" modified="2010-05-18" version="1">MAPCLLRFPLLLLLTAVGADAAALNIQDEAQVPLVTAVDEADNVQGEGHSGLHGRFLHITDIHADLFYKAHTKIKNDCHRGHGIAGFFGTPGTDCDTPETLLDATFDWIGNNLRDKVDFVIWTGDAARHDKDERRPRSEKEIVSTNRLVFDKFVKTFHKPKDELGNTLKVPIIPTFGNNDIMPHNIMERGPNKWTRIFSELWGAVIPEEQRHSFAIGGWFYVEAIPGKLAVISLNTMYFYRANSAVDGCNSKYEPGFEHMEWLRTHLQLLRDRGMKAILIGHVPPAQNKKKKNWSGSCWQKYAIWMKQYRDVVVGSFYGHMNLDHFILQDFDDIKYIIGDESEYDTSHEKSGKDVSITVSMGYLRKLKKLWSKLPQPPWAEQDQANTAGYKKELKKYYNEVGGPWAERYFMSFVSPSVIPNFFPSIRVVEYNISGIEHSKKWPQPPYLSPNQDNTPLSYLDEDDRDDDNDQDNTSIDISKKHKKRKKHKKKYPKFTVPNPPSRTSPPGPAYSNQPLSLLGYQQYFANLTELNQAHDEKSLELSEVDATKKSKAPKDFYHLEYDTRTDPYYQLPDMTMNSYLELARRIAREEEVPVHDNEKSSDGDGPSILKRTVSLWTVFRQRAFVGFFNARMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I3</accession>
    <name>D4D4I3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023803.1">
        <property type="nucleotide sequence ID" value="XM_003023757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I3"/>
    <dbReference type="GeneID" id="9582376"/>
    <dbReference type="KEGG" id="tve:TRV_02000"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="248"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="471" mass="54470" checksum="3A4E25A565E17DC2" modified="2010-05-18" version="1">MSDGTLFKPEKDFTKDVDQQIPEAEALAKASDLPSTSRLLVGIVTICKNAREWELLNEQVIALSKKHGQLKQAITKMVQVVMEFLDKTPNLETKLALIETLRTVTEGKIFVEVERARVTRALSDIKKSQGDIDAAADILCELQVETFGSMARREKTEFILEQVALCIKRKDWTQANILSRKITTKFFARKPKRTPEQIEKDNKEAEEKEKKRSPDDPPVEKPEDVTDLKLLYYEQQIILANHESKYLDVCKHYRQVLDTESVEENPEQLRAVLQRVIYYVILSPFDNEQSDLLHRIQADTRNSLVPVEARLVKLFTINELMRWPMVAEQFGPHLCSTDVFSAKTNHTADDQAYQRWQDLRKRVIEHNVRVIAKYYTRIEMGRLTQLLDLDEEETEKYISDLVTSKTIYAKIDRPARLVNFAKPRDADDVLNEWSSNMKSLLGLLERIDHLITKEEMMARILPSKAGRSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D560</accession>
    <name>D4D560_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023655.1">
        <property type="nucleotide sequence ID" value="XM_003023609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D560"/>
    <dbReference type="GeneID" id="9582201"/>
    <dbReference type="KEGG" id="tve:TRV_02230"/>
    <dbReference type="HOGENOM" id="CLU_2086544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="117" mass="12541" checksum="010C87C8AAD90E6D" modified="2010-05-18" version="1">MDMDMGIGIGIGIGMGMGMGMDRQHGGMAGERHGMAMDKGRAWASAWGMEMGQGPPGRFGGRGQRAGRVSASFRVVVVVIVAEKRSRGGRGGRLDGVLERLKYQSQSEKEEEVEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5A1</accession>
    <name>D4D5A1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrin-binding protein Sfi1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023524.1">
        <property type="nucleotide sequence ID" value="XM_003023478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5A1"/>
    <dbReference type="GeneID" id="9576996"/>
    <dbReference type="KEGG" id="tve:TRV_02271"/>
    <dbReference type="HOGENOM" id="CLU_007577_0_0_1"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="3">
        <location>
            <begin position="354"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1064" mass="124307" checksum="2B5B77ECDBF260A9" modified="2010-05-18" version="1">MGFLLAAGELELIQSYNTTDVELLHEIVTRAEQHPDADILPFRVIFSAYDAVLSEHGIPVESDQTYLPFLFQLGAERNGTISERFESLLASLGIRLEYGEDAESNEPLPTNGVASRSREDSARILQQRPNGILPRRAEDRRRASFDSVYDTTHDFEQRFANRPNSRSSMSRLEDGTIRSLDFDAEIKRLYPYKSDRSPQHEGLGDAVGRDVNGIASQDSDGGANSLSSESSENSSTQEFGSAHRMNSNKILEHQYSENALSIASDETPEPPQVPPELFYQPSNTQRIRDASVFDMYRRRNALRLMLSSWSKSAKRKRELVQAMEQRAIYYDSKTLVVQVLDLWKAALQDKREVAEAEREAAQNEKFFNNLEERAARARDIYLLTKAFTHWSQIASEEVHRTEAARRHLLCIKYFNAWREITAVDELKAQRFMLRKPLKLWSGRHQQIAPLDSQAEEFRQRSLKRYGYSHWFWSFCDRLAPRWNKERLKQRSFIAWLRALRTQRERDLAIDSNRSLNSLKITFQTLVQKYREVSSAEKSANNHWKYHVTSNYLTEWSVKQKYRRPFAELTSLLNTRLVRSCLEDWSQQTRMERRARDADRLRVMRNCWTTWNDHLRCQALSSRTEERIVLQSLYKWILIGRLRLLDRIHQQRLKASYLKTLMENSRSLYNELLVKEARFRTDRKRKLAQATFSYWKQRLDIQKQRELVSRAFYAPPVQQEVLQNWKARSEHLATLDTWAKKSEYFFLTTKTLKQWRSAAAESSKRRRLEAYAAIRRKVKMNLATAVISAWRSRCATVREIHQRSTEMYGEKLIAIGTNMFHLWSEKATQRAQHLADAQLYYNRQLVYNNLTHWAGMQRSYQMLDEKATRFLEIHVSGIALAQIRKLSLRIFEVKTRLETADALYGRNTRKHYRNMIHHWREKARISKDFDSFPIETPSKNGHSIQVNDPHGWPRIDHPREREEPPIRQPDFTSHTPISTPGYLNSPSKRAARARALVQMSTTPATPLPTSFPSKLWAASEPRLQPIYSTRRSAFKRGATSTNVRFAIDEEPESPTEGRSTGRELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M2</accession>
    <name>D4D5M2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000123">
        <property type="protein sequence ID" value="EFE42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023471.1">
        <property type="nucleotide sequence ID" value="XM_003023425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M2"/>
    <dbReference type="GeneID" id="9583490"/>
    <dbReference type="KEGG" id="tve:TRV_02395"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_1_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="229" mass="26339" checksum="9EBCAE2F4EE02A22" modified="2010-05-18" version="1" fragment="single">MSEFGRQRVGRDHGAEEEEPGHRQSPRGRHEAPQKGVQDPPLRYYLFLLLIVQLMIAVLRGAGSGESGKSTIVKQMKIIHQNGYSVEELSMYRLTVYKNLLDCAKSLVWAMHQFEIQPSSAKVRDFMDYLLDYNIDPDPNVALELKVGDAITYLWNDPSIPAVLERQNEFYLMDSAPYYMLIADSFFEEAKRITMPDYIPNEADVLRARTKTTGIYETRFTMGQLSIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5R1</accession>
    <name>D4D5R1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023450.1">
        <property type="nucleotide sequence ID" value="XM_003023404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5R1"/>
    <dbReference type="GeneID" id="9583470"/>
    <dbReference type="KEGG" id="tve:TRV_02434"/>
    <dbReference type="HOGENOM" id="CLU_043453_2_0_1"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28501" checksum="2AB746ACBB474CB2" modified="2010-05-18" version="1" fragment="single">ARNSEKAQSMLFRFRAAQAADLGILDIGRTRRPKAITSIDSIPVCEKWRGQVLKEISRKVTRIQDLSLSDFQIRDLNDEINKLMREKWMWEVQIRNLGGPNYTRGGGRVYDEDGKEIPGGGKGYRYFGRARELPGVKEMFEAATKKRSASELDDTGGRKMDIEMFKKHVDAAYFGYGLDEEDGSLLAYEKKKEKEAFEAVLKKGDDKPIDGWEPLPGDAGDGVEWQLPTLDDVQEELVERRRRKLLDKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5V8</accession>
    <name>D4D5V8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023379.1">
        <property type="nucleotide sequence ID" value="XM_003023333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5V8"/>
    <dbReference type="GeneID" id="9583399"/>
    <dbReference type="KEGG" id="tve:TRV_02481"/>
    <dbReference type="HOGENOM" id="CLU_024934_5_2_1"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50005" checksum="84B45A626384EAD1" modified="2010-05-18" version="1">MSSRRSHRKSRTGCYQCKRRRIKPPNSFYASFVPLPTTQPETTSDSPAPVIAPPIAPSPITPASGPTDTPITPATSAPRHTPTIPPTTSAPIQFRSIAPSATQLPAILNQGPPPSPAWATGIERHSIFSSIPDRFREDKSLNLEDLELLHHYTTKTYQTLSNNNEHEEIWKNVIPGEAIKHPFLMHGLLALAALHIIECHDPDDGEIRRKYSALANKHQNLALATFRPELNNITPSNCHAVFAFSSLIAALAFAFSRSERNSQPADHIEQAVQDFYLFRGVDKVLHAQWSRIVKGKLGALVRRPADSSAAYPLSKDVIDNLDYLHSCNGDSAAHIPAEEKAIYNHAIRELRMSFERSPSSWEGVFRWPMVVPEPYLGLLNSRKPMALVILGHYCVILSRLDMCWWSEGWSQHLFEAIYKSLHPSWRTLVQWPMQMIGLSEQLAHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D664</accession>
    <name>D4D664_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023253.1">
        <property type="nucleotide sequence ID" value="XM_003023207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D664"/>
    <dbReference type="GeneID" id="9583286"/>
    <dbReference type="KEGG" id="tve:TRV_02587"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="549" mass="60194" checksum="ACFB23FA4CA28F0B" modified="2010-05-18" version="1">MTQAQESLARFQARREEALSKVDVDLSRIPEKLSGNVTDIPRQCLSQEDIGITESSAQSLLASLAQGTLTATAVTKAFLRRAVIAQKLVNCVHELLPERALARAKELDEYFAKHKKPIGPLHGLPVSVKAHMGVKGCDTSSGFVAWAGRPSPDDAELLKILIAAGAVEYVRTTEPQALLMLETKSNVTGETVNPHNIALTPGGSSGGESALQALYGSPLGIGTDMGGSIRSPASNCGLYGFKPTTHRIPLTGWTAYNIGVETIWGTAGPLCPTFEGIDLMMKVILDAEPWRKDPSLHQMHWREHAQCINPKGEKKFRVGVMWDDGIVKPLPPVTRALHEVVAKLKLVPGVEVVEWKPFHHDEAMEILAGLYSPDGGKSYEALLQEGGESALQLANWVAKESPAVKAHDLPALWNLLKRREAYRFNYLTEWNKLEPDMDVILCPAHPNVAPVLSTSRYWGYTSIWNILDYPAIVFPVTRINAQLDTKETGYTPRNDDDALYQDNYDPVIQASAPVCLQLVGKKMQDEMVVQAMKEIKDAIGLPFVNCLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E5</accession>
    <name>D4D6E5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-C domain protein HetC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023207.1">
        <property type="nucleotide sequence ID" value="XM_003023161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E5"/>
    <dbReference type="GeneID" id="9583227"/>
    <dbReference type="KEGG" id="tve:TRV_02670"/>
    <dbReference type="HOGENOM" id="CLU_010063_0_0_1"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056019" description="HET-C domain protein HetC" evidence="2">
        <location>
            <begin position="26"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="87293" checksum="3525C025C2CC53E4" modified="2010-05-18" version="1">MGFNPTTTILLIALLLVVLPARVEAFGAGNIASVSAVEGKNWRHGDIEDVIKTLAFIKGHKWTANMVKRVYFGNWLRYYSQAVDVGTLKNVPADSVRVLVWVLSFMTFGYATAEFEVTSERLGVYRPEEHIDNPKGYADDADARQYDPRLRGPVQRVELEIDHETGMKNYIANERGNWATSAAYVKYSFSRSIHFARQYINGGHLRRGNDEDLYEALRCLGQGLHTLEDFGAHTNYCELALREMGMLNVFPHTGTNTMMNIKGKHIFPLVTGTFGMVDFLHSVLGEASDHVTQSEISELDTTLENAEVGGATTGSVNALTSLLSKVPGMGDLIAEAEKLKASSQAQAQANSNAGYGYGGASRGLDDGQTQAYGAAGGYDQTSRAGPGGLPSVDPQKVISQIYPILVFRDNVVRRISSVVSKIPGLESLVEKITDTLSVFIFSLLSPFVRPLIKVATSQLQTGSSGVISTSEQHQYEPWTDPNCTDPTHSLLSKDHFSNILNEPAGHVAAAILKYVVPRVLYAWQHVDIPVDDVLADCMRVFHHPALRDMNNEAHRTMFEAVQNWARSRRDGGASLDTILNAQSVREGKNHTGGNPHLQGGGHGHGSGHGSGHGSGHGYGQQPMHGGAHGYQPPYQQQQQHQSYNSPHYGQQSYPHQGGGSSHHSSNPLSNIPGLSALAGLAGNSSHHGAGHSNAGSAASSIPWDKLSHLPIPGASNIGKIGGFLSGSGGRTRDIGDETSRGIAPEEHPASRSTTPQPDMPPPAGYEHYHQQREDFVRNQTETDARAGPRKTEDPIRKRPASEAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6V5</accession>
    <name>D4D6V5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023011.1">
        <property type="nucleotide sequence ID" value="XM_003022965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6V5"/>
    <dbReference type="GeneID" id="9583031"/>
    <dbReference type="KEGG" id="tve:TRV_02832"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="483" mass="52204" checksum="0C0001C1C638EA84" modified="2010-05-18" version="1">METGSAYLLTGCVLQLPLALLYKFFTPKWVFIFMLIVFEIGSAVCGGAQNSVSIIVGRAIQGLGGAGIFSGSMVLIVEAVPLAKRPMYMGFGGATFGLSAVLGPLVGGALTSNASWRWCFLINLPIGGMVLLVLLWFFPNTHTMDEQCGPQKENSVQKSIQEKFLDLDPMGIIFLVPGMVFLMLALQLGGSVYVWSNGRIIVLFVVAGILFVSFILNEIYQRERAMLKMTVFTQRTVFGSFFYSFCVGGSMMTIVYYLPIWFQAIKGASAVKSGEMNIPLLLSLMIGTLLAGMLVSKIVGYAAPFMIVGAIIMTIGAGLFSTFGISTSHAKWIGYQVVYGFGLGLGMQQGAAAIQAVIPKHDTPQAISFLFFGQQLGGAIMLCIGENLLNSSLVRNIRTSLPNIDPGHISNSGATDFRNTVSGPDMIKLLQAYNGALRHVFFLPIAVSGLALVGAFPVEWKNLIKVEKEQSAEKDRLSRVTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6W9</accession>
    <name>D4D6W9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_02846</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023025.1">
        <property type="nucleotide sequence ID" value="XM_003022979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6W9"/>
    <dbReference type="GeneID" id="9583045"/>
    <dbReference type="KEGG" id="tve:TRV_02846"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="229"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="433"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="677" mass="72107" checksum="F5D3A79AE5E725B7" modified="2010-05-18" version="1">MADNLKIGNLSLNDSQHAPNQTGRSAYIPPHLRGQARQAAAAESAAGPTVDGPDGPAPGQNGRPAGMNASAWAPGAPNNAPGWGAGDYGPRGGPAVNGNSGWGQPAGSRRTFDPHAYGHPGHQGQQGGNYGGGGAARGSGDGQWRDGKHIPGPSNARLERELFGIPNDPSKQHTGINFANYDDIPVEASGQNVPEPVSTFTNPPLDDHLISNIKLASYKVPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQAFQNGPSPAPTQQGGQFSYGRQRKAYPTSLILAPTRELVSQIYDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLCNIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPPVAGRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDNDKRSVLLDILHTHGAGLTLIFVETKRMADSLSEFLINQHFPATAIHGDRTQRERERALEYFRNGRCPILVATAVAARGLDIPNVTHVVNYDLPTDIDDYVHRIGRTGRAGNTGISTAFFNRGNRGVVRDLIELLKEAHQEVPSFLENIAREGSGYGGRGGRGRGRGSAGANRDMRRMGGGMGGPPSYGGGGNYAAPQSYGGGGGNYGGGPYGGGYGGGGYGNPSGPTGPSSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D778</accession>
    <name>D4D778_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02958</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022910.1">
        <property type="nucleotide sequence ID" value="XM_003022864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D778"/>
    <dbReference type="GeneID" id="9576948"/>
    <dbReference type="KEGG" id="tve:TRV_02958"/>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21692" checksum="E8C0B80A3B0351C8" modified="2010-05-18" version="1">MSQLPSKPSEDENRLEAQIQDILSRRETLISQLSRLLDSESALTASALKQNNLSRHREVLLEHRQELKRLKATISDTRDRVNLLSNVRSDIDAYRASNPAGAEADYMLEERGRLDNSHNMMDSVLSQAYAVNESFGFQRETLASINRRIVGAASQIPGVNNLINKISAKRRRDGIILGTFIGICCLMVFFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7C3</accession>
    <name>D4D7C3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000156">
        <property type="protein sequence ID" value="EFE42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022866.1">
        <property type="nucleotide sequence ID" value="XM_003022820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7C3"/>
    <dbReference type="GeneID" id="9581593"/>
    <dbReference type="KEGG" id="tve:TRV_03005"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_13_1"/>
    <dbReference type="OrthoDB" id="4172657at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="292"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128169" checksum="4954361AA829280C" modified="2010-05-18" version="1">MEKSKFASRGPSAKNGASDIFEIVSLYEPAKVEHAVADILLIPGLTGDPVNTWSYGDICWPRDLLPQALSSPVRILSFGYNPSRHSNVYPDIEDSALHLISELERVRPVKIASINKYRKALILCSDKPSLRRIPAALSGIVFLAAPHRGSSLAGTANRLMRQLRIRLPRKFISALKKNSVELERIATDFQQIANQRSLPIFSFYELLPVRGRLSCFVDIVVDKDSALLRIPSESALGVYTNHRDICRYRDFDNPIFRDVTRHLQQLVDLGPQHSSARVFLPFDGTPHFVGRQDYLQQIHNAFNGSDNRQVIALYGEGGAGKTEIALKYARENANHYDYVFFVDSTDTQSLESDFIRHHRKLGLPPSNSCALNDIKQFLRLERFWLMILDNDNNWLALNWLGFPEITHGHIIITSRHREHTSDSRVTKALSTNPLGPMDARNFLLSRAGIDVEEWLSWETKAESVAKHMGCQPLAVDSAAAYMLAYGVTVDEYLNALTGSRVSRRLLFYRPNASIYKTSVESIIQLALDEVKKNPDAFRLLNILVWLDRTKTTISFLKRAVSRQPRWGHDGQVEMRDPLRSYVPPDLVRLINGPSFHIALKELQSCSLIASGKMFEDGRSPRCKDTIVLHPLTYLYIREALPPTKMLENAIHALSLVVHAYPVAQAGLDQSLNREYLAEENIDLIKAIEKVDIRADEERTFAEITAEMFMEVARGYGEGSSHLENTLPRWIKTLINSLEKAGLHARLWCTRLPLEFYSKGKFTDGCEAAAAFLRDAKFSPGDKITNNDNAQAGFLRHMSVEYLARDDSLSDREEWEKRAKYIEAWKPLDPHAPSELERYAQGMGIRMRGKLAKDFGLFNEAYFSLKLFIEQYAKRGSREEGWAIGDLGQVVLELEGADEDCDALSDFMTTGINCGHDQSIPETDARPCEVITQIYSQAIESRTIARGSSSQYDRDNVRESDTMFLEINCAVSILREGIFRPERYAEAEQKLIRLKDRFENMLTTGTLWHDDQTRHFSVLAYLAQISHLQMDWEVAQSRWIETIDYGQSSVRGWDGDHYYIDVARYSLANAQLRAGGEPDAIVAKLDKIVHRLNAEVVTWNLGLGTFWLEYIRKSMTEVKKLRGKGDVGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L3</accession>
    <name>D4D7L3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAS small monomeric GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022799.1">
        <property type="nucleotide sequence ID" value="XM_003022753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L3"/>
    <dbReference type="GeneID" id="9581476"/>
    <dbReference type="KEGG" id="tve:TRV_03096"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_2_1"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="37363" checksum="5A3F4217A01BE105" modified="2010-05-18" version="1">MIHREDEDEDEDDEEGQSNRMRCYRRLLLGDSDGRRAAEEYRGLWAASNLNSDAFLLVYDITNEPTLETLGHFMEMIDMETENREEQNIRLLKQFYRDYPDQPPEDVPTLGMPPPVKIVAGNKCDLKEARVISSRRGLEWARSRGCGFMETKARKLHREQQIAQLHAFKEAEQLSSASRFFSAACRRATEPIALSQTAPLTTEERQDPTGRSVSSGARSRRRSIWLIVQQALTRRANAANSKRPRSGQPILNPNQWENQSQGQGHSQGQSRPGTLSTHSSKKPDPDMGEPGYPNNYPHSDHRHAGLGQFKPSERVSIPWWKTLCCCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7P3</accession>
    <name>D4D7P3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022745.1">
        <property type="nucleotide sequence ID" value="XM_003022699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7P3"/>
    <dbReference type="GeneID" id="9581435"/>
    <dbReference type="KEGG" id="tve:TRV_03127"/>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="637"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="85741" checksum="981FDFE430DAA055" modified="2010-05-18" version="1">MAPLRLRVEGNVFRDPHNREVILRGINLDATAKYPRIPDVPSHEVNGFFDADDVSFVNRPFTLEDSHTHFSRLKKWGYNHIRYVFTWEAIEHTGPGQYDEEWITFTIELLRIAGLYGFYVYMDPHQDVWSRFSGGSGAPLWTLYAAGLDPRNFHDTQAALVQNTYPDPAAFPKMIWSTNYTRLVCQTMFTLFWAGKDFAPKAIINGMNIQDYLQTHFIAACKHLAVRIHEAGDLEDDVVIGWENVNEPHRGMIGIPDISVIPADQQLQLGTSPTAFQGMMIGSGFPCEVTQWEFGTFGPHQTGRTLVDPEGKSVWSKVDRADQYGWKRDPQWKLGECIWAQHGVWDPATLTLLRSNYFGTHPRTGQALDYEGFINTYFLEHYRKYRDALRSVHKDTIMFCQPPVLEIPPTIKGTVDDDPNMVHAVHFYDGLTLMSKHWNRYYNVDVVGILRGKYWIPAFGLKIGETAIRNSFRDQLHYLREESYKNMGNHPLLLTETGIPYDMDDKYAYKTGDYSSQISAMDANHFGIEGCGGNGYSLWTYASENSHKWGDNWNGEDLSIYSPDDLELPIAKSLESGMTLLDPSSPSFSQSRADSQAIRVEPSNLKAALPAASITTKPQLKESGEHRGFRAVEAFVRPGPEAVHGRITKHGFDLQNCTFTLSLTADSPTASGAPTLIFLPELHFPKDRSTVNVSGGKWEIFSLEFQHGSIQFLNWWHAAGDQTIQIHGVKRELSAIVSPHDDEGYIEQCKQHSCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Y6</accession>
    <name>D4D7Y6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000165">
        <property type="protein sequence ID" value="EFE42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022660.1">
        <property type="nucleotide sequence ID" value="XM_003022614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Y6"/>
    <dbReference type="GeneID" id="9581318"/>
    <dbReference type="KEGG" id="tve:TRV_03220"/>
    <dbReference type="HOGENOM" id="CLU_1918587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="132" mass="14665" checksum="18A0924A5FD6ECB5" modified="2010-05-18" version="1">MVSAMASGSDEKTRRCMEGQSRSAVSVDVDVDVADGGRKRERNSEEIKNLAGCSKGIFVCSSLSLAEEEQAWKRGNAPKVEGGGQKSGRRRLRYLWKEHGRCCCSFLTFGTFRKQNNPAQEHDDGYQETIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D881</accession>
    <name>D4D881_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">RNA helicase/RNAse III, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_03317</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000171">
        <property type="protein sequence ID" value="EFE41937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022555.1">
        <property type="nucleotide sequence ID" value="XM_003022509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581213"/>
    <dbReference type="KEGG" id="tve:TRV_03317"/>
    <dbReference type="HOGENOM" id="CLU_000907_4_6_1"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000032">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="64"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="420"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="20">
        <location>
            <begin position="635"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="998"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1186"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE41937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1468" mass="166100" checksum="B5BB933B2C14CC06" modified="2010-05-18" version="1">MAAAKPELPGQMLALEEHKRGRKRPRSSSGSNGMPQNEAARKASLEGLEDALGSIRPRGYQREMLEASIKQNIIVAMDTGSGKTQIAILRIRHELERCSNDKLVWFLAPRVPLAEQQYRAISEQLPAYQTKILTGADNLERWSTQQIWDAFLLNTRIVVSTPQILLDVLSNGFITLRRIALLVFDEAHHCVKASPENKIMRNFYHARIDQLSETNDLPSILGLTASPTSKLIEDSLSRQCECSLLMESRQLEQNLDAFCKTPAIHREEMMQYVHIPELRKISYQKDSIIPHNMKVKFLHMLDDIDIESDPFFQRYKGKTDSKSTERFLRALARKTPGLDQLKRCFTKVSHMYGELGHWASSAFISEIYRRTREERAKLVDHSWSEWDRDDSSFMCNALEPVVAIMGERCWNSTPDAVSQKVEHLVDLLSSELTGSSRGIIFVEQRATAVMLSHLISRYPELAHIKSDYFLGNSAFSARKADLTELSKPGDMKNSIDDLKSGKKNLLVATSVLEEGIDVSACDLVVCFDPPKQLRSFVQRRGRARKKSSKFVIFYAEDDTATYKDWEAMEDIMKERYLSNKEFIDRLREEDDEEEVEYESLRIESTGYGVTPGLLLWDCLLTIYYTVRALLTLENARAHLSHFCSTIPCEFTDTQPDFIISKTGIKDMLTAKVLLPTVLDLQFREFEGIQAWKREKMAKRDAAFQAYLQLYKASLVNDHLMPEHCRTTDEETAHIEKRSSMTTCSEVFNPWKMVADRWHSTDTFYQSSIVISSGTEELPKMILILPIPLPCDFTVKLFWNETSTLSASVSPQELTVSDEDIVSAPLATHILLSSVFPSRMNGTSRDFSCIFVPELARGHGGHESWCTKVNKSILGRDIESGGLGSIGDFGLARRTDIYARAWVAERFVWMKRVREEDDSESVEDEEEEGEILHVEGEKWPKRADFLHPVANSTGSKPHHTARNCIPARQSCISMLPVGFAKFALFIPSLIHTIGRYLLAEELSKTILSPIGFQNIQLVLTAITATSAREDTNYQRLEFLGDSALKLHASMQLLAEHPLWHEGILSKKKDSIVSNSRLWKAAVDTGLDQFILTTCFTGAKWRPLYNSTYTNNAGKIGEKSTRKLSTKTLADVVESLIGVAIIDGGENKVLRCLELFLPEINWLPSGERIEILYDSAPDFNDDCPRDILSKIEPLIDYSFTKKALLAASLSHPSNPISGMTYQRLEFLGDSILDNIVTRALFRCKREIPHQDMHLIRTALVNADFLAFLCMNTSTDETREDVCVSPTGEVEVTSSTRQVSLWQYMSHSSTDIVETQQAMARTFEELRDQIENALRSGARYPWTLLSTLNAPKFFSDIIESILGAIFIDSRGSILACQKFLTRIGLMDYLQRVLEDDGIDFMHPKQRLGVVAQSLSVQYVVSEVHVKPGVTQWKCQVLVGDEEISRVDDGVSQNQARAKAADLALEVLRTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8C4</accession>
    <name>D4D8C4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022518.1">
        <property type="nucleotide sequence ID" value="XM_003022472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8C4"/>
    <dbReference type="GeneID" id="9581094"/>
    <dbReference type="KEGG" id="tve:TRV_03360"/>
    <dbReference type="HOGENOM" id="CLU_042059_1_0_1"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="367" mass="39622" checksum="0F6F1C6D56A11AE3" modified="2010-05-18" version="1">MGPKSASTASPGKRGRPSTKAGTATSTKVSVEVPVPKGAVARETSSFSLESVLHFALLASSSLLLSTALFSLSVPITKGDLAWTSKRLDSWRDVMVLLAWRVIELAVPWFSGYDAWDALCFIGLIHLPAYSLLLNFYNIRPTTIIAVATFTILSSTIPFSYFRPLGPAHSGSPAVNRAILADGLTTAYITVASTLVYTTFIYLSFVTWLPTHLVTYFNGLPDITAAHAGPKGFVSLFLSLLPAGYGARDLLFVTSASQPPEKKTEPKTTRRRLRSSDSRNEEEEQREESCIASLYKKAWLGLSPASRTLISRSLALALMTLANTFVQLAGTISGVEPKGALGWGSIWSLATLVNAFFYGWVQEASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8G0</accession>
    <name>D4D8G0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022446.1">
        <property type="nucleotide sequence ID" value="XM_003022400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8G0"/>
    <dbReference type="GeneID" id="9580993"/>
    <dbReference type="KEGG" id="tve:TRV_03396"/>
    <dbReference type="HOGENOM" id="CLU_039952_1_2_1"/>
    <dbReference type="OrthoDB" id="5398854at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52037" checksum="F3AF356F65C6FC46" modified="2010-05-18" version="1">MYHYPSPPSGWSAYDGYTPPSPHYSSYYGPPPPSASASASAQAAQAAAAAAAAAFATGSPHATPRSKKHAYRASFSAGYSQQTPQQNYQYSWQPPYDRPEYFSTPRKQHSQPHHDHVSPDYYYYHHSHHGYGKQTQHSPNHHQRPKHRRKMSVPDNVSDDGSIPGLDEYDGYYYQQPRRRPSATTYYTRRRASTNHYHYPQTSSAAAAAAAAYDDPLDTPKRSRARRASTFTRPTHSSAHDPYSQSHSASKPKPSAYHSASHSHHAQPAPPKSPPRATEADAIHHNIPPGYSIKNWNPKEAPILLLGSVFDANSLGKWIYDWTAFHHGATAPMADVAGDLWLLLIKLAGKVKRADECAPLIRSTEAREMVEDFLESGERLWARFKRLLKACEHFMWKAAKREHAARGGSPATITMGRNAGCEFVDSIFGRDRELENTEKLMNSVRLWNMRFDANCGELLREVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8L2</accession>
    <name>D4D8L2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022385.1">
        <property type="nucleotide sequence ID" value="XM_003022339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8L2"/>
    <dbReference type="GeneID" id="9580932"/>
    <dbReference type="KEGG" id="tve:TRV_03449"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="90"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="194"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="37818" checksum="B71143D1FA48846E" modified="2010-05-18" version="1">MIAGGIGGTSGDMLMHSLDTVKTRQQGDPHIPPKYTSMSSSYATIFRQEGIRRGLYGGVTPALCGSFPGTVIFFGTYECSKRWMLDVGINPSIAYLAGGFIADFAASFIYVPSEVLKTRLQLQGRYNNPFFKSGYNYRSTADAFRTILRTEGFFALFSGFKATLFRDMPFSALQFAFYEQEQQLAKRWVGHRDIGFQLEVLTAATAGGMAGVITCPLDVVKTRIQTQQNPDAAPRPTVTPNGHVHAPSSPSTSTSKSSAQTRFISTSSPSTSTVKPGAAILDTSSVLTGLKLIYKTEGVAGWFRGVGPRFLWTSIQSGTMLVLYQYFLKQLESYQQLRELRSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8P9</accession>
    <name>D4D8P9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022422.1">
        <property type="nucleotide sequence ID" value="XM_003022376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8P9"/>
    <dbReference type="GeneID" id="9580969"/>
    <dbReference type="KEGG" id="tve:TRV_03486"/>
    <dbReference type="HOGENOM" id="CLU_075862_0_1_1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055674" description="N-acetylglucosamine-induced protein 1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22636" checksum="E6996E96D2047785" modified="2010-05-18" version="1">MYGVKWRAVALILSFIASNQLELLKRKPSDLRRYAAWSSTIKARYGNIANFLCKERLHWPIDRDPQTLCQNPTLFADPRDYKILRNDWPYGLTPDITHMCVWVKNRIDTTPETGDVTEESRALIDDFVHRTFTSHLSGFSDAADRVIWFKNWTALQSIRSLEHIHVLVRDIPDKVIVEWTGEEARELSQPDGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Z9</accession>
    <name>D4D8Z9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022265.1">
        <property type="nucleotide sequence ID" value="XM_003022219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Z9"/>
    <dbReference type="GeneID" id="9576871"/>
    <dbReference type="KEGG" id="tve:TRV_03587"/>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_1"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="50227" checksum="D96B8E3E87E9832D" modified="2010-05-18" version="1">MKITGFTSHDVRFPTSLDNTGSDAMNAATDYSAAYCVLQTDSTHTGHGMTFTIGRGNEIVCTAIDALATLLVGKELESLTADWGKTWRYLVSDSQLRWIGPEKGVIHLALGAIVNALWDLWAKTLNKPVWRVVADMTPEEVVTCIDFRYITDALTPEEAIKLLREVEPGKRQRIEEAESNQAVPAYTTSAGWLGYNEEKVKSLLEKSVQDGYRYFKLKVGGDLDMDKRRLAIARDAIGYDKGNVLMIDANQVWSVPEAISHMKELAQFKPWFIEEPTSPDDILGHAAIREALQDTPHGAIGVATGEMCQNRVMFKQFLQSGALSVVQPDACRVGGVNECLAILLLARKFGVPVVPHSGGVGLPEYTQHLSTIDYVVMTGKKSVLEYVDHLHEHFEYPARVRNGYYVTPMEPGYSVQMKAHSMEKYSFPGEDGKSWWRSEEAKPVLQRARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D921</accession>
    <name>D4D921_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved glutamic acid-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022287.1">
        <property type="nucleotide sequence ID" value="XM_003022241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D921"/>
    <dbReference type="GeneID" id="9576890"/>
    <dbReference type="KEGG" id="tve:TRV_03611"/>
    <dbReference type="HOGENOM" id="CLU_1687990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="148" mass="15971" checksum="527806BA8687E851" modified="2010-05-18" version="1">MVVDGEADADADADADVGVGARFDDESDFEGEEESEENEDEEPAEEPEPSAKRRKTGRAAAAKKAPVDDEEEDEEEIEEEEEQEQGEEEKDEEEEAEGDDEEKDGDAEDDDEVAEKPASDKKAAAAAATTAAAAGGEEEEEEEEEANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9H0</accession>
    <name>D4D9H0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000193">
        <property type="protein sequence ID" value="EFE41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022118.1">
        <property type="nucleotide sequence ID" value="XM_003022072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9H0"/>
    <dbReference type="GeneID" id="9579003"/>
    <dbReference type="KEGG" id="tve:TRV_03763"/>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="345"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="580" mass="66466" checksum="4E93EB3F7D70D888" modified="2010-05-18" version="1">MASAVNGELKGSKKRKKSDSESARRSMKRRAVEGENGKDKLEIEHIQELEDQIAESRKYYNNIVTLLSKLDDASTDKAGKKALAVSLCRVFCRLLAGGQLNPPKSAVENETKLVAWLKERYQEYKTALVGILRDGEPSQQITALSLSMQLIKEQVAHYTGSDINVWSSGYFNDILAAVVQPGNDKLRAHFMDSFFQKYHDITVYTVLRLAYVFFTYQLTKHQLYALTPTKNRTYLSEQRDAETLDSTVDLLSNIGEPTDLQQRFETTYTDTSKISPKNKGPFTSENSFKIRVQTAWLAVLRNPMTKSQRKHLLRIMSHVVVPWFAKPELLMDFLTDCYNEGGSTSLLSLSGLFYLIQEKNLDYPQFYTKLYSLLDRDVLHSKHRSRFFRLMDTFLASSHLPATLVASFIKRLSRLALNAPPAAIVAIVPWIYNMLKSHPTCTFMIHRDLKKHDPSLYEEIEEEGMDDPFDACEPNPTLTNAIESSLWEIETLQSHYHPNTAALARIISEQFTKQHYNVEDFLDLSYQALLGTELGKEEKAFKKAPVVEFQIPKRIFTDRGLEGREEDTEPGHMLRELWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9P2</accession>
    <name>D4D9P2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022018.1">
        <property type="nucleotide sequence ID" value="XM_003021972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9P2"/>
    <dbReference type="GeneID" id="9578902"/>
    <dbReference type="KEGG" id="tve:TRV_03835"/>
    <dbReference type="HOGENOM" id="CLU_008827_0_0_1"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="89026" checksum="8A89C0D6FB8FB719" modified="2010-05-18" version="1">MSIVATASPGSQRMSSNTASYQFTPPHNPSVLPQSPRSPVRSPTFPLLYSNHAASSSVPSLYSPATVRYSFYPPTKHGRTSPQDQQPMQVFTNRLPDEAYECILSHLWSLHISSCTEGCLTCYMRDLYSLSLTDRAWEKAVRAANGYRYNKIHLHGSDSPGPLKKYKWKRGSRLKLLRRTLRERKALANMVFELRVPELDAPLITGKQHLVLQEYRDLVASVVMVCPNLERLLGLSIPYNHEFDRLTHALSTRKKLKEHAWIIGPNAEVTERSQNKATEVLDQAQVYQFLSHHTSWSKLESMVLHSMDSKGILEHGVFIRMFNFLPALQNLSVSGFEADNFTDRTLLFLPALASLRLEGLQGVTENGLARYVGRPEARGLKSLALIEQNISSLLILSKILASLGCLERFTIVQSSVVPSLPEGGMVFQPLLASATLKHLHWDVACPNGADALNQIDTVPFSKVLNTANTPNSHLAQSILHVGFPSLERLRAPLDIDPLGALQNVCRPSKNGLIMVPADRHNLPRSSHGSLPKRPLAMPAGNNLSSARIRSQALIDMAAKENDEGVKVIITDHSEDFLTPNVVIQPGYVSSEAILALNDGKAQTPALKILEFLIPACMGRVGISNKSNTTALTPRFTLQPDIPNSDADGGLISHKHLFAANQTSLFASCSSSSTHPAIPAVSQHSKRTNTNSSFSDEISSPSTATTTTSSSSRFSVWGGSNARSNHSNSKSTSSNPPMPPKTPTSPTKGTSWPTTGGNGDQPFWARDTCNGSWNQGHKYGKEWWSHAERERNIGGIKKPNTSAALLGVSDIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9P4</accession>
    <name>D4D9P4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022020.1">
        <property type="nucleotide sequence ID" value="XM_003021974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9P4"/>
    <dbReference type="GeneID" id="9578904"/>
    <dbReference type="KEGG" id="tve:TRV_03837"/>
    <dbReference type="HOGENOM" id="CLU_021859_3_2_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="206" mass="23388" checksum="16EC458CAB3849CB" modified="2010-05-18" version="1">MKDTAYTSQHLNAHTDTTYFTDPAGLQLFHILSHTDGKGGETLLVDGFKAARTLLEEDPVAYQTLSDIKISSHSSGNKDVCIQPATSFSVLNHMSDSSELYQIRWNNDDRAPGKGNSLETIHRWYQAAKKWNAILKRSDMEIWLKLEPGTPLSKCLLPRMKMIEKEGKLTAFHHPVFDNWRILHGRSAFTGKRRMCGGYSEYSRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9X9</accession>
    <name>D4D9X9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021974.1">
        <property type="nucleotide sequence ID" value="XM_003021928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9X9"/>
    <dbReference type="GeneID" id="9578847"/>
    <dbReference type="KEGG" id="tve:TRV_03922"/>
    <dbReference type="HOGENOM" id="CLU_2063185_0_0_1"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="119" mass="12973" checksum="08F52D0EC38C655A" modified="2010-05-18" version="1">MSSQPASQGAAKPQSAETAQSEKAQNLSAPLEEDDEFEDFPVEDWPQEEAEAPSGGSGNDHLWEESWDDDDASEDFSKQLAWKLPSDDLAVVKEWTLICAATSFLLVSSSASWVFFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA05</accession>
    <name>D4DA05_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021919.1">
        <property type="nucleotide sequence ID" value="XM_003021873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA05"/>
    <dbReference type="GeneID" id="9578802"/>
    <dbReference type="KEGG" id="tve:TRV_03949"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="538" mass="61005" checksum="607189B5DC077BC3" modified="2010-05-18" version="1">MLMSGEMSGDPPRNLNMKEKFDRWYALSSWPDDGVPLANVVTTGWLTMGGEDLGMLNYSLKDNLSKARGLLGSSYAVARAAALVLHFDVAVILFHKSIAFHQITAWSIVFFSLLHTIAHWVNFARIAASEGLGIKGFLQLNVTTGPGWTGYVMLAALVAIALTSLEGPRRANHERFWNTHHLFIIFFLFWSFHGAFCMIKPDLPPFCDGTGVFYLYWIFGGSVYLLERLMREVRGKHRTIITKVIQHPSNVFEIQLQKEKTKMRPGQYIFINCPVVSIWQYHPFTLTSAPEEDYISVHIRCVGNFTKDLAKAVGCDFDEKEQPSYERRTRRESTVIGVDANTSEQDVDPRLSRILPRIFIDGPFGSASEDVFKFEVAVLVGAGIGVTPFASILKSIWYRMSQRQNKTRLKKVYFFWVCRDFGSFEWFSSLLLAIEAQDRYSNIEIHTYLTAKIQSDDATNIMINDADADRDAITGLRAPTNFGRPNWDMVFRSIRKIHAPAEAGVFFCGPKALGSVLHVKCNMYSEPGFNFVWGEENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB67</accession>
    <name>D4DB67_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acyl-CoA oxidase</fullName>
            <ecNumber evidence="6">1.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04366</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.6" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021519.1">
        <property type="nucleotide sequence ID" value="XM_003021473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB67"/>
    <dbReference type="GeneID" id="9578480"/>
    <dbReference type="KEGG" id="tve:TRV_04366"/>
    <dbReference type="HOGENOM" id="CLU_014629_4_2_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="160"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="276"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="417"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="13">
        <location>
            <begin position="639"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="827" mass="92573" checksum="4EFCE73CE9276997" modified="2010-05-18" version="1">MHAKLGAGKKLVMKKHCARDFQRLKPRRMVFSLPKPLSTSASFFRLPGASAYREIPKIRPGDAEEEPASCDQKALLVSCLLVLISGSSLPRSLLPQFLPFCFPSSPAFVRSLASLYLLSELLFIYIITMVSSPDWVKKLAPAGPQGSELLKHERGQSNISVDKLAELLHTKEVLERQDRILSLIQHEEVFDKSQNHSLGRVERVKKALARAKRLEQLKRQHNWSEDDFIMANNLISEPTPYGLHASMFLVTLRNQGTPEQHKLFLEPAERYEIIGCYAQTELAHGSNVRGLETTATWNPEDKTFTIHSPSLTAAKWWIGSLGRTANHAVVMAQLYINGKNYGPHPFVVQIRDLKTHEPLENVHVGDIGPKFGYNTMDNGFLLFNKVKIPHINMLARFSGVDPNTNKYVRPASPSLIYGTLTWVRSTIVLQSGGVLARGVTIATRYCAVRRQFQDRDAPANAPGDNQVLDYKMVQIRLFPLLAATFALHFSGRGMMALYNHNQAIMKKSASNQASGRGAGPEELNPGADLLADLHATSCGLKALASTIAAEGLEVCRRACGGHGYSSHSGIGPWYSDYLPNTTWEGDNYMLTQQVARYLLKSARSVFVGKPANNDTCAILQSYLSRRETGAAFDILENDADIVAAFAWRAAYLTFEALKHRDVEKRSWNSLLVDFWRLSTAHSQYLVVKNFYEAVFPSGSSAEVAASLGIDEPTLDVLRKLFRLHSLHTLERESADFFTSGAVTTRQIILTRTKAVMRLLDEIRPHAVRLVDSWKFPDWQLDSSLGRFDGKVYEDLFRRASEENPLNELTFDPYPMSNTLVKNEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB74</accession>
    <name>D4DB74_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021526.1">
        <property type="nucleotide sequence ID" value="XM_003021480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB74"/>
    <dbReference type="GeneID" id="9578487"/>
    <dbReference type="KEGG" id="tve:TRV_04373"/>
    <dbReference type="HOGENOM" id="CLU_002149_2_0_1"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="338"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="639"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="723"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="845" mass="93905" checksum="F65CF81822C81DE7" modified="2010-05-18" version="1">MEGEGLFSQARICIVCSAQLNAEQAEEISSALREHGGEVVINEPQTPLPPVNEFSHIISPTIDFQGHDAACDALIPVVKPQWVQMSISKQKLANPRQYNPDPRLFMNDVIVTCEDIPEGDKDAIIGGVLAMGGLYTSRITNSTTHLVTLTMNERCMAAKKRGLATKIVLPHCRFDDCLKLGRRIDERPYLLPNPEILRPENERPPRIAANRDVMGASTPEPNALPDRAASPGGSRKELSIFKGKTVMISSDLGIAEHMASSIEELIREGGGQTTNEVSKCDIFICRYREGEDYKMASRAGKEVGNLSWLFHLITHNAWTSPLRRLLHYPIAREGIPGFNKFKISLSNYAGEARIYLENLIAAAGAESTKTLKQENTHLLTAHKNSEKCTAAKEWNLHIVNHLWLEESYAKWQQQSVTDPRYTHFPRRTNLSDVVGQTRIDRYTVEEHFFPPEPAPGIKKPATLPQKGNNATLNRSSGNVKTPRSGRKAINEGPDMPGPEPDNTTKVTKKLKEKPLQTPVPSRFADLGKENETPSTTGSRKSKDIAAAKLHNLAPDISLYEKELKRVGGVIYGGRRKSAGEPDSAKKRSAEPDSASASEDAIETKRIKTSKPPIAIRLVITGFNRWVEKPNIEDSERTQLRDLGILVIPDPSRCTHLAAPSIKRTQKFLNALAHAPVIINSNFITDCLEKKELLDPNDYILKDKASEKKYNFTLEKARQRAKKNQQKLLSGHTIYCTDKVNGGIEAFQAIIEANGGQCVPYRGRPGTMISSRRLAADGPDQSEADDVYLISGTDKSSVKLWDKFRTMARNAKRVPRVVSSDWLLDIALSQEWRNGDSYELPDENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC2</accession>
    <name>D4DBC2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000221">
        <property type="protein sequence ID" value="EFE40862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021480.1">
        <property type="nucleotide sequence ID" value="XM_003021434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC2"/>
    <dbReference type="GeneID" id="9578441"/>
    <dbReference type="KEGG" id="tve:TRV_04421"/>
    <dbReference type="HOGENOM" id="CLU_2628775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="78" mass="9041" checksum="852C35EB7EFACEE4" modified="2010-05-18" version="1" fragment="single">MRKAARVLCWRKEEENIDRPACRFRFLDEVEECPSIYPRETSLSLDEDSVLAEEEKTIGPTVATSSLLPFPEDFIVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC4</accession>
    <name>D4DBC4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04423</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021450.1">
        <property type="nucleotide sequence ID" value="XM_003021404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC4"/>
    <dbReference type="GeneID" id="9578411"/>
    <dbReference type="KEGG" id="tve:TRV_04423"/>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056364" description="Oxidoreductin" evidence="20">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE40832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61833" checksum="2DE18B001CF95D18" modified="2010-05-18" version="1">MGGASKLFYLAVFSLLAPAHGEDNSSRSRSCAIDARSTVSDACASFATFDGLNNQITPVLKSLTQHSDFFSYYRLNLFNKQCPFWSDDAGMCGNIACAVSTLESEKDIPLIWRAEELSKLEGPKAGHPGKKQQKERPKEKPLQGMLGEDVKESCVVEYDDECDERDYCVPEDEGATGKGDYVSLLDNPERFTGYSGPGARHVWNAIYRENCFIKPMQKSRLIPNNVFGVPMGSQLRAVDDFRHVLESHEVNQVVSGAVRDELYPLDDECLEKRVFHRLISGMHASISTHLCWDYFNQTTGKWGPNMQCFKDRLHTHPERIANLYFNFGVLTRAVAKLQKHLQGYSFCISDPDQDYETKQKMNSLTQILATHPQIFDETTMFQDTVANGLKEDFRNRFRNVSRVMDCIGCDKCRLWGKLQTAGYGAALKVLFEYDETKNGENPPLRRTELVALVNTLARVSHSLGSIQKFEDIIKNEIAANEAGTAKVEKQEEQPVSEDIDDEPEIYTHSEGDDVSPSIMTMIKQEAALIWRAYIFIVKSWINFPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBE3</accession>
    <name>D4DBE3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000223">
        <property type="protein sequence ID" value="EFE40829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021447.1">
        <property type="nucleotide sequence ID" value="XM_003021401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBE3"/>
    <dbReference type="GeneID" id="9578409"/>
    <dbReference type="KEGG" id="tve:TRV_04443"/>
    <dbReference type="HOGENOM" id="CLU_1171343_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056584">
        <property type="entry name" value="EF-hand_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23617">
        <property type="entry name" value="EF-hand_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="237" mass="26118" checksum="67103BB5BB510B86" modified="2010-05-18" version="1">MVVEVLFVGGGRTEEANETRGFPLKAGTSSASAPTSTQLHPFSPPYINKQDQTSQSHLELDIKLLPVPKMASPTTSAPAAPSTYKVDSFNPAVLDHLRRIYESLQSQGQTPTGPDGATLSASAHFLQNIQKDQHFKADQPRGGQQHGVLDSFSSFLDYMSTASAMPQFSDTQAYEEDLSFPMPNYFINSSHNTYLTGNQLYSESSTEVYKNVCGWICFNDFFSPHPLLPFLLLLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK8</accession>
    <name>D4DBK8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endosomal sorting complex protein TSG101, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021434.1">
        <property type="nucleotide sequence ID" value="XM_003021388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK8"/>
    <dbReference type="GeneID" id="9578394"/>
    <dbReference type="KEGG" id="tve:TRV_04508"/>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SB" evidence="7">
        <location>
            <begin position="400"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="466" mass="50477" checksum="321F41724DD8566D" modified="2010-05-18" version="1">MPDGLCDPNVRDVAHWAEARDRSTLVDFLLILKEVFAKEPPVISKDAPFRRQPTPSQQSTPPAVPPLPAELARPSPSVAPSTQPQTPPKLPPKPGGERHQAASERPAEDTVTARNVPPPLPPLPAELQSTTHQRDGPGLENRGNQFLPQRSSALRSEVTPAPQPPPPTHPSQHQTQGFILGAHDRRPSNVQSPPVGSTPHAPQYQQAYQPPYPRQQFSPQHNNTIMHPSQQHAIHHQHSPLHVPQRDAQSPLAAKSSPKKGETQDLLTSPFDLELPAQLPSSSPPPIPPNPEKDVLLQTLSGTLTQTIHANVEQSNSRIEPLNSQSKALHDAISTLRSEIAAVNAFHANIQSNTQILQQSLRRADGVIADAKSRISSSSASSSKHPAGLPAIDEVLVPPTVVGKQIYDLVTDERGIQRAIYALQSALVRGRVGVDVWAKSTRNLAREAFLKKALIRKAANGMGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC35</accession>
    <name>D4DC35_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021255.1">
        <property type="nucleotide sequence ID" value="XM_003021209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC35"/>
    <dbReference type="GeneID" id="9578100"/>
    <dbReference type="KEGG" id="tve:TRV_04687"/>
    <dbReference type="HOGENOM" id="CLU_066296_1_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056376" evidence="2">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="275" mass="29791" checksum="71F07642607AA3FD" modified="2010-05-18" version="1">MGKSVLKAWMLSWAMVHETKGLVLLPNERIIYTSPLRTSIALKSIHPGPDKQSFARQASTGHVHLTNQRIVYLPSQPTQEFQSFSAPLLNLIDTHVAAPFFGPNVWNAVVQPVSGGGIPASFAAIQLKLTFKDGGAFDFHSNYEQIKERLQQAVERARESGLMSGDGAQVGGSGRDGGAFGVVDFANVHLEDLPAYESNSTTGNNHDISGTLPPQTTTTTTTTTTTATATSAANEDSRSGRQSFETPTDPPPGYEEVQQQSVANELENQLRRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC56</accession>
    <name>D4DC56_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021191.1">
        <property type="nucleotide sequence ID" value="XM_003021145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC56"/>
    <dbReference type="GeneID" id="9578035"/>
    <dbReference type="KEGG" id="tve:TRV_04708"/>
    <dbReference type="HOGENOM" id="CLU_591962_0_0_1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="52968" checksum="5FFE5F653912B68C" modified="2010-05-18" version="1">MPVSPADEGRKNVTGYRRHVAHVESTLRPLIALLLVWITLTIDRHLLQCSYPRVSRISQLKVLRERLQALENVMATKDSAAFTQPQDMQIAASPITASSIQEIGLPQIYPVESQWYMPELLRFYSESIALQSQGDGSFTQLDTLRNIWMTTSLTDECMFHATLYAASAYLDLLRGQSGNVITLYHQTETLRLLSSQLAAPNLQVTDALIAVTMALSQTEALSGNVCVSGVHRAGLHHLVKIKGGPENLGMDGLLAKLIYVGDAMDCLLYGTEQSFQWATNPTPPPMALLSNVLSWETSAHKTSPTCQSSANILGLVQQSMLLIDNLPSASVENVIAPSFIQKFIHLHDEFSSLCRDNTIHSSSDSSAEVYINECCRQTALLHWRLVNDKGIFSTEDTILADGKDLKVAMGKMDIPTWSKVAPRVFIWAGVTGAAASKECAERAWFAARLGPVVMAQGKDGIPTLKQGMALYHWLKAPVVGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY4</accession>
    <name>D4DCY4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020914.1">
        <property type="nucleotide sequence ID" value="XM_003020868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY4"/>
    <dbReference type="GeneID" id="9577735"/>
    <dbReference type="KEGG" id="tve:TRV_04990"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="50141" checksum="C2C004FE37F7FDDF" modified="2010-05-18" version="1">MDLSREDQLDSRLPANQYIQEPQVKPEKIGGESIMGRAENPLEPATWPGLPKIEEGLAYITRQSKKTFVAFVGLLTLFNSVFDSTIPSGGIRFIAAALNVQGESQLALPTSVFLIGYVTGPLAFGPMSEVYGRRVVMIGSFVLFTIFTLACAVAPSWLALIIFRSLCGIFASTPIAVTGGIFADIYRSPLTRGRVMALSMAVTAAGPQFAPVIAGFVATAGWKWIFWVSLIVAVATLVPVLFLPETFQPALMKQPQRRGEGVVTKALARPLYMLFCEPILSFTCLYLSYASAIFFAVGAGIGLGIFLAYDSFLQRAKSRRTSWSSIEEYQRLPLACLGGPLYMVALFWLGWSSSPDIHWIVPMLAGIPFGMGFFLIFVALINYLIDAYHEYAASAMAAASCCRSIFGAVLPLAAVPMFRQLGIAWGCSLLGFLSLLMSLIPFVFIRYGDKIRSRSRYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD10</accession>
    <name>D4DD10_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020878.1">
        <property type="nucleotide sequence ID" value="XM_003020832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD10"/>
    <dbReference type="GeneID" id="9577709"/>
    <dbReference type="KEGG" id="tve:TRV_05016"/>
    <dbReference type="HOGENOM" id="CLU_2238576_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="105" mass="11900" checksum="21DD0B885D3027BB" modified="2010-05-18" version="1">MGAKQKPGLSTVLKQQKKKKTRDKDQTARDSPLSLSYQSFPLSSGRQKRADGVPGRASGESSALLLPDRKEKKRDEKREEEEKKKKEKNKVTALTMFPGVYKYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD41</accession>
    <name>D4DD41_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020822.1">
        <property type="nucleotide sequence ID" value="XM_003020776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD41"/>
    <dbReference type="GeneID" id="9577593"/>
    <dbReference type="KEGG" id="tve:TRV_05048"/>
    <dbReference type="HOGENOM" id="CLU_3260409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="42" mass="4814" checksum="DFB6B4A0B3328FB7" modified="2010-05-18" version="1">MQFGLVQQGEEKKTEEEKKEKEELYLRPVSNSPSSSTNNVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD76</accession>
    <name>D4DD76_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GARP complex subunit (Sac2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020807.1">
        <property type="nucleotide sequence ID" value="XM_003020761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD76"/>
    <dbReference type="GeneID" id="9577558"/>
    <dbReference type="KEGG" id="tve:TRV_05083"/>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="201"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="376"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="718" mass="80059" checksum="8C590B837ABE3B2C" modified="2010-05-18" version="1">MWPDRGAAGQGGPVASASAGSLPYSPARRQSQLSAANKPGRPSFSPRSSSLSFSPTPNASTTSLPGAARAANGLSRQPPSAMRNQSYPDPVDVLNGIIGQRRSSSTSGDEAASPPEKPDVLCENIDFGGLSLEEFAHQMETLPARRNYGQGLQSFEQYENDRNIFEELHNSITVCHISRFHSDLSPDTTKRPPQLIIFALQGCDEILKSVESYLTKFQAELGAISSKIESLQSRSFRLSSQLENRKNVERILGPAVEKVSVSPHTVRSISDRPIDQEWVKALSELDTLSSTINADTSTPENIKAIEDVRPLLKNLQEKAVERIRDFLVTQIKAIRSPNMNAQVIQQQSLLKYKDLYTYLSTHHPTLSEEITQAYVNTMRWYYLSNFTRYSQALDKLKLYSIDRNDLLGGDASSQRTGKSYFYIYILQAHGGSGGRSPALAAHDPLALGRRMDILKSSSHMALSSYLAEEDKSTHGLEIVFRNFNLALIDNISAEYSFMAEMFSAKTIHYTSQKVTEIFEPTFASGQAITKQLIDTTTDCIGILLCVRLNQQFAFEMQRRKVPVADPYINGINMQLWPRFQMIMDMHFESLKRISTASTRSGLSVLALTSTDAQSSAPHFLTQRFGQFLHSILTLCNEAGDDEPIFNSLGRLVNEFDALLTKLSKSSGDAKRRERFLFNNYSLILTIISDTKGKLATDQKEVRAYYKQFIVVFDILTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD89</accession>
    <name>D4DD89_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020789.1">
        <property type="nucleotide sequence ID" value="XM_003020743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD89"/>
    <dbReference type="GeneID" id="9577540"/>
    <dbReference type="KEGG" id="tve:TRV_05096"/>
    <dbReference type="HOGENOM" id="CLU_010811_4_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="298"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="918" mass="100867" checksum="2E1E71EED8FA2910" modified="2010-05-18" version="1">MDPLGPGNGSGHPPNRLRKTPTLQINSQVQREPSNPFADASSSSNNNISSASTLAGPSPITPRALISPQQRTFSPSPAPADSLSRNESTERLAVPGPGGSLPRSRAYVDDSQSGYPYPTSQNQQQLQQQRYSGGNGGGGGAYGADYTSFSSRRTSWSSDAASRHASYGYGGYTYSSPFDDSRVPSRAGSSDDEGGITTQTVTEKFAIFPDGDLIVYPHDVEKDDELHNPDPNDKERKCDIWHKRGITNIGALIFLIGGVLTLFIGYPVISYIQGLTSIKGGCAGDPMCIDADIPLLKNIRTGLIDPDTPKSAMKKKSANGKDLELVFSDEFNLDGRTFFQEDDPYLQAVDIWYGVTQDLEWYDPDAVTTKNGKLELRFDAFQNHYLNYRSGMVQSWNQMCFTGGRLEASISLPGRGDVSGLWPGFWAMGNLGRPGYPATTDGMWPYSYHDKCDAGITANQSDPGGLSFLPGMRLPACTCDDADHPTPGKSRTSPEIDVIEASVHALHGEKKPINVIGDVSQSCQVAPFDVWYMPDYGKGKNQLTKADFTELYDPEITIMNAYRGGVYQQAISGVTNLNNNWYNGKEYQVYAFDYIPGDKGEITWYVGKEKSWKLDARALGPNGNVGQRVIPREPMALIANLGMSNSFAALNLTGLAPLFPATMRIDYIRIYQEKDKKSVTCDPPGMETTDYIRKHKDVYHNPNLTTCGRGRAGGSYIHPSYSNKSLPRIPDPPPPSPRPAFRLFCSPIQSPKSEHATRQATRTFRAPALLTVGFLFLFLQGGYGLSLAEEQLRAWLWLSHLAGTAPFSRAVVDGPGKYISHLPPRQTRDVYCWMTRRCLDPCLPPTSIVQLGATWLKTHHTSSSSTKNTTHATSRRHAMPCHAMLCHLKPARIESSLNNRETRTSTTNNHTSTPENAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDM0</accession>
    <name>D4DDM0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020705.1">
        <property type="nucleotide sequence ID" value="XM_003020659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDM0"/>
    <dbReference type="GeneID" id="9577404"/>
    <dbReference type="KEGG" id="tve:TRV_05231"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="620" mass="68735" checksum="D526183A73C5783C" modified="2010-05-18" version="1">MGLDLEANGDEHPFLMNETVEHLSWKGVTVSVKDRETKQPKAILRDATGYVNKGELMVLMGPSGSGKTTLLNVLAGRANSLRDGVNGEVLVNGRAASKETFRHLSSYVEQEDVLIGSLTVEETLYFAAQLSLSRSIPKKDRIQRIKYLLNSFGIQNQAKTLIGTPIRKGISGGQKRRVSVAAQLITCPKIIFLDEPTSGLDSTASYEVMSFVKALARKNNPSTSMFESFDKLLILSAGKTCYFGPGKDMKAYLDKTGHPMPVQINPAEFVLDLVSTDFATDTEEAEAQLAKIHQEWEDSEESSNVNLEISRLTTLSEKEENITLSADQLQHVNIVSTIVTLLHRSFIKGCRDVVAYGIRVAMYLGLAIMEGTVWLRLGTGQENIQPYINALFFCSAFMSFMAVAYVPSFLEDRATFIKERANGLYGATSFVISNFLIGMPFLSDPIAVMITIIFSVVAYWLVNFRSGADTFFTLVMWLFLDLLAAESLVVMIASLFPNFVVALALTAFTNGIWMSVGGFMVAPAILNVFWRYVFHYIDYQTYVFQGMMVNEFSGRVFDCGKSCQCMYASELASQCQISGKGILNSFGYATDKQAQWAGILISITAVYRILGWIVLYMKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDM9</accession>
    <name>D4DDM9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIY-YIG catalytic domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020642.1">
        <property type="nucleotide sequence ID" value="XM_003020596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDM9"/>
    <dbReference type="GeneID" id="9577341"/>
    <dbReference type="KEGG" id="tve:TRV_05240"/>
    <dbReference type="HOGENOM" id="CLU_030739_1_0_1"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Structure-specific endonuclease subunit SLX1 C-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="32082" checksum="B853DBB0257BA384" modified="2010-05-18" version="1">METKVRICSKTGRRLATKSSNPRESMTSTMARLHVLLRSPYFSSWPLQVRFFNTDIHRVWRGWAESASTFVPEHISFETDFDDGALSGEGLPLQNTLRKLDVSGKNLRSYREKTQFLLDAGDKLDCGVCRSRLRLNDDFVVVCSSEMCRCTSHLLCLSSRFMHSEDSSNDLVPMSGRCPGCESIIEWHILMREMTLRIRSHRRGTFDNDDSLEEEDEAGVELSEDARIQSPIDLLSSEDDDFGPSTSTYDLNVDYRRQHQPISNTPGKGKIDDWDDVDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE37</accession>
    <name>D4DE37_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020507.1">
        <property type="nucleotide sequence ID" value="XM_003020461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE37"/>
    <dbReference type="GeneID" id="9584255"/>
    <dbReference type="KEGG" id="tve:TRV_05401"/>
    <dbReference type="HOGENOM" id="CLU_051385_2_0_1"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="274" mass="31345" checksum="54968F830E917550" modified="2010-05-18" version="1">MSREPKYSVLLVWQIANALALHRITDTKVANLKIWRNVVFGSEAYPFDPNKRPEGAAEDHTHQWRVFVRGINGEDISYWLKKVQFKLHETYAQSVRTIEAPPFEVTETGWGEFEIQIKLYFVPESMEKPQTLWHGLKLHPYGSDVEGKKARRETVVSQNYEEVLFNEPVEQFYDLLTGGTGVAQQQTKGKSTKGKQAQLPPTALGKRTAEIPHTDSPKNPYSRKSEAKEVDRIIEATKTVEKILKDEKAKLLEREKVLAGLKETEGTSLLQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH0</accession>
    <name>D4DEH0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_05537</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020366.1">
        <property type="nucleotide sequence ID" value="XM_003020320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH0"/>
    <dbReference type="GeneID" id="9584105"/>
    <dbReference type="KEGG" id="tve:TRV_05537"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="58684" checksum="16884D60DD60DBCB" modified="2010-05-18" version="1">MLNIFLGRADSPNYRVVTPPSGELQTLIVKPETESVRPYVAGAVFRNIRFDQARYNSFIALQDKLHQNIARQRTLVSIGTHDLDTIQGPFTYEALPPKDIKFIPLNQTKCMDGEELMEFYEKDKNLGKYLHIIRDSPVYPVIYDSKRTVCSLPPIINGDHSKITLNTRNVFMEITATDKTKLEVVNNIMVTMFSQCTDEPFTIEPIKIVSEHNGESRQVPTLEPRTTQASIAYINQCTGLSLSGPETCKLLKKMALSAKVSETSDDTLDVTIPVTRADILHQADIMEDVAIAHGFNELPRSFPSKSGTIAQPLPINKLGDIIRGEAAMAGWTEVLTFALCSHDENFSWVNRKDDGTTAVKLANPKTVEFQVVRTSLLPGLLKTIRENKNHSLPIKIFEVSDVGLKDLSLERKSRNERHFAAAWYGKTSGFEVVHGLLDKVMMMMKSGFIVGEEGLDNAAVKGSQYWIEELDDPTYFPGHAASIHLRMDGKESVIGTFGILHPTVLENFDLRHPVSALEINIETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH2</accession>
    <name>D4DEH2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020368.1">
        <property type="nucleotide sequence ID" value="XM_003020322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH2"/>
    <dbReference type="GeneID" id="9584107"/>
    <dbReference type="KEGG" id="tve:TRV_05539"/>
    <dbReference type="HOGENOM" id="CLU_001839_5_1_1"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17666">
        <property type="entry name" value="PTP-MTM-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="139"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="424"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="769" mass="86413" checksum="165B6074EAF88C3A" modified="2010-05-18" version="1">MGAHVSQVDEVTLFRRGEKAIGSLHLTPHHIVFSYIPPQKESSREHSKDKPTVGHKEIWITYPIICFCTYRPASLASRQPASIRLRCRDFSFMCFTFPNEARSRDVYETIRTWTCKLGSIEKLYAFTFQPPAAELALNGWELYNPRKEWARLGVGRADQDSNWRISCINTDYKLTFPGKFSPTYPALLPVPSNISDNTINYAGRYRSRARIPVLTYLHPVNNCSITRSSQPLVGVRNNRSIQDEKLLAAIFSTSRQDRPLANASPPSLETESSNSSAEEQFGIHSDFEFSNAEELEDEVVASARNDIKDYKTQIYGAQQNNLIVDARPTVNALAMQAVGLGSENMDNYKFAAKAYLGIDNIHVMRDSLNKVIEALRDSDISPLPPNRDQLLKSGWLKYIAVILDGAALIARQVGLQHSHVLIHCSDGWDRTGQLSALSQLCLDPYYRTLEGFMVLVEKDWLAFGHMFRHRSGHLNSDKWFQVENDRGSDSARGAFEGGVAGKALENALLSAKGFFNRDNVSRESLVEGDGDRTDPDSSNSKRATSNPKSPVSDSDMTKPKETSPVFHQFLDATYQLLYQHPTRFEFNERFLRRLLYHVYSGQYGTFLYNSEKERVDRGAKEKTRSVWDYFLARRSQFINPEYDPLIDDNKRGSERLLFPRTYEVRWWAESFGRNDSEMNNPRIANSGVLVERDCPSGSMTPMVAVETADRSVTPVAVSQQLAAPQSSTTGPTTSITSLAANISGLSLPVGKGDGPGTINAREMEAVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEL2</accession>
    <name>D4DEL2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000299">
        <property type="protein sequence ID" value="EFE39717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020335.1">
        <property type="nucleotide sequence ID" value="XM_003020289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEL2"/>
    <dbReference type="GeneID" id="9584072"/>
    <dbReference type="KEGG" id="tve:TRV_05579"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="184"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="304"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="391" mass="42050" checksum="E07BD027AC6FA911" modified="2010-05-18" version="1">MASLSTASGMHGGARLKGHGSDSNGSDRVHTNRSVLVQSGEIDDVDVAPGREKVEKPAVKPWAHFLAGGLGGMTAATLTSPLDVLKTRLQSDFYQAQLQQLRAQHPLPPASSSIAALTRSAAVHFSETIQMLRSIHVHEGWRALFKGLGPNLTGVVPARAINFYVYGNGKRILNDYFRYDPNESPVAIHLGAAAIAGIATGTATNPIWLVKTRMQLDKNASQQQGGGQAVRKRQYANSLDCIRQTVRHEGIQGLYRGLSASYLGVSESALQWVLYEQMKRVLAQREARLAADPTHVPGWMDDVISWGGKLVAAGSAKLVAAVATYPHEVVRTRLRQAPTAPAGSGKAQLKYTGLAQCFKVVWKEEGMAGMYGGLTPHLLRVVPSAAIMFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DER2</accession>
    <name>D4DER2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal brevianamide peptide synthase FtmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000307">
        <property type="protein sequence ID" value="EFE39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020273.1">
        <property type="nucleotide sequence ID" value="XM_003020227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584018"/>
    <dbReference type="KEGG" id="tve:TRV_05651"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="783"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1945" mass="216144" checksum="A4B3963A2E42E8EF" modified="2010-05-18" version="1">MTIFNPDVCLTASTRDNKPSQSTNICVFPKLNHRPVKLEHEKTGFVELKPLDLHQSNVCLKSTLKIAWSILLARYTDTNPVAFRTVTRYQRNDILGIGCGHSDTPSCFEQLVASIDEQKQGFLAVSLSQIEDSGYNASFNTGLLFGPCESLQGCDDLKGLEVIVNLNESAPVPRISLWYSRYIVDDAQARNLASELERILKSLIDEPHCTLADHNSIISNHHLQQIISWNSQAPSEPLDTNIPTLIRQQCLMRPNSQAVCSWDGDLTYRELDRLSSVVQAKLRDRGIGLGAIVPLQFEKSKWTPVAILGVLKAGAAFVLLDPSYPRSRTEAICRDIEATVIISFAEQRATSSSFIETVIVVDNTIKNDERIHIPRQASVRPDDVAYIAYTSGSTGVPKGIMIEHASFCLNSISSSNAHNLDHSSRVLQFASYAFDVSIHENLTPLILGGCVCIPSESQRVNQLQDAIVGLGVNWMELTPSVARLLRPEDIPSVKTLVLGGEAMLPADISMWSDKVRLVCAYGPAECTVVSTVLSEDCQPGNIGRSYAGTCWIVDKDNHHQLVPIGVTGELVIGGFIVGRGYLNRPQQTASAFIQNPDWIPKVFPMGSNMRLYKTGDLARYNSDGTIMCQGRKDTQVKLHGQRIELGEVEHHTQKWFPDSVVAAEVVVPASQKEKSPSLVLFVAEEQGIQEHIGDSLVRPLNENFRVIAQEMKDKLRDELPRYMIPTAVLPLVKMPLSRTGKIDRKILRNAVANLPESDFQQYRSALQRSSLKENMGSRILKAAPTTDSERLLQKLYSKVLGLSEDEVGREDSFFELGGDSISAITLVGMAREEYNLQIKVASLFAAPAIYEMAQTMEFVTQDSMQICAPFSMLKASELQTVTEQAIEQCQISRDQIEDIYGCTPLQEGLMSWSARNPGSFQARFIFRLPDTIDTQKFHEAWCYAFNSTPILRTRIIQTDASFRALQVIVKDKLRWFSSEDRDVAAADPMSYGTPLVRCIMDNSCHQKNEAPIFTLEMHHALFDKWSYEQILQIVEVAYESRTVELFPFSPFVHHLSAVNPEYTKTFWKNEFQSLKAPVFPLRMPEGYVPREIAVASRNVPLGASTGVGGFTASTLIRLSWAMLIAQDTQSNDVVHGATVTGRNAPVPGIEKIVGPTIATFPVRTVLDRNDPIKVALGKVQNHATALIPFEQTAMQGIRSCSPEASIACDFQSLLVIQPSSKNNQNPQTWLLKLGESLEDETKFCTYVLTVICELEVESVSVRAIFDAAVLSLDKVNAMLGQLEYLLTRLVDSVDSQTLGEVMDMCKFGSSVHDECKVEQLNSQKTRLAAIEAAARNLIGNRHVYAEMITPKLMSSPRKTLALLKRQLHTATEFVAAPPICIPLGYMWDNGICAQDRQNLKEALTRLTSNEIEAWLQKSGRQQPKSEAERKLASIISRVLHLNPEEVGADEDFFALGGDSISVMQVVSQCQRDKLSITAMDIFEGRTVSLITARSKKAAKLPPSTNLARYKRTKRFEWEVENLLGSSTTMSIEEVYPCTPYHEGLVIPQLGNDAYVSHTIWKVERIGSTSQIDPVQLQKAWYQLAQRHAALRTILVEAALEDVEGGTLTHVVLDSYPREVKILSCTDDEAMRVLRHPTLNSRDNAGPVLPHVFSICQTDTGQVYCKMEGKHAIIDAVSVILLIKELALAYEGKLPSRQGLEYSSWVSYALSLPDCMDFWLEYLAGAKPCHFPRLSREIQPVTGFLNSVEVSLGHPSPPRKLCALNGLTITNLLQIAWGIVLRQHTGSDDVCFGTLVTGREAPLPGVHDIVGSIFNVLACRLTLSENMSLRECLQENQVAMANRLSNQYCSLFEVMQRIDSTGSLFNTCLSVEQPLSNSNQKEPGVHFEALETREATEYDIVTVVTVGEAEMTANITYWSSVLTREQAIAVGREFRLAISTITEHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEU9</accession>
    <name>D4DEU9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020250.1">
        <property type="nucleotide sequence ID" value="XM_003020204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEU9"/>
    <dbReference type="GeneID" id="9582791"/>
    <dbReference type="KEGG" id="tve:TRV_05689"/>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38474" checksum="5607351F512BE79E" modified="2010-05-18" version="1">MLCADVFDRSISIACWVVVFSPQIIENFRRSSADGLSLEFLIVWLAGDVFNIIGAVMQGVLPTMIILAVYYTIADIVLLGQCFYYRGLGISESTKPPEPEAGRASSSSETAIQTVPSSERTPLLHNTPGGEHNGSNGRPATKQRRESLTSVASLRNHLTAVDGTHLSPAVPLRKEVTDTPPRPSSTFQIIAFNTFSITLVCAAGILGWYVSATSRKRHHKGDDIPKSDGTLQFDITGQVFGYLCALFYLASRIPQLLLNWRRKSTEGVSLLFFLFACIGNLTYVLSIFAYSPVCQGKNGRCLPGERQSIYGRYMAVNASWLLGSLGTLFMDLAIFSQFILYRSKDECNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF58</accession>
    <name>D4DF58_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000334">
        <property type="protein sequence ID" value="EFE39509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020133.1">
        <property type="nucleotide sequence ID" value="XM_003020087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF58"/>
    <dbReference type="GeneID" id="9583897"/>
    <dbReference type="KEGG" id="tve:TRV_05803"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_3_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="71" mass="8165" checksum="6668D950FA3000D4" modified="2010-05-18" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRLQYTRRFVNVTMTGGKRKVRFIHLEMMDISRAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFR7</accession>
    <name>D4DFR7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-specific adenosine-34 deaminase subunit Tad3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019917.1">
        <property type="nucleotide sequence ID" value="XM_003019871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFR7"/>
    <dbReference type="GeneID" id="9584668"/>
    <dbReference type="KEGG" id="tve:TRV_06018"/>
    <dbReference type="HOGENOM" id="CLU_024580_0_0_1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="443" mass="49013" checksum="62AF83ACE4905830" modified="2010-05-18" version="1">MAVEERLRGIKPLQGELDTLPSVQELRPVDSFEEAYVAEIDIKSSNVVVKLLDTHYPRNPEVSRSHLRRLLRPENLPEPLRQELEEAQGPKPTASIHVLIPPPLPETSELQALLAPYTPRISPPSHSGSDTTTTTTEQPSPEKLPTVRIQKTLISTKPPTTPAEALEWSCTKWSTIYNPAARVAAHAPPQVQLVRAKASIYPRAGYFLALAKEVANETLQSGRGRGVGVVIVDPELTVGKPDDTNDLLNAVVAVSGDTRWWKASLGHEHENEHERKQQQHQEKEYSIDDEAGPESHAVMRGISMVSRKRIALNKPVTDEVEEEVSAPSEVESAPLSSTSLESHFFQLPNLLKSSKGGYLCTGLDLYITHEPCICCSMGMLLSRFRSITVLNSGMRRSAESNALDAVNGYGLHWREELNWRAIGFEFFESGGGEGKAEREEFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFW7</accession>
    <name>D4DFW7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliotoxin biosynthesis protein GliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019872.1">
        <property type="nucleotide sequence ID" value="XM_003019826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFW7"/>
    <dbReference type="GeneID" id="9584623"/>
    <dbReference type="KEGG" id="tve:TRV_06070"/>
    <dbReference type="HOGENOM" id="CLU_030506_1_0_1"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="33909" checksum="7C803A5432CE4CCB" modified="2010-05-18" version="1">MFVSPSPLPKAEAAKERLVWYLAYGSNLSAKTFREDRGMTPQAAVAVKVAGWRLAMSSAGFPYREPCYASITEYKPATEKIVENGVDDDEVLCGTAYLITWAQWIEIIGSEGGGIAYDEALVAAQPVHPAHRQRWGDQIRVLTLVSTMERWPEARPTERYLVSLIISFFPPFLSVSKSWRSTQNKLTFLPPRSRSFKGLILDGAQAANFPPSYIERIRQKYPCYQPPSTAWERMGAAIFLAFWTPVMSLLSTLTHSTARTGPGKDGHVPPAVRALVRFAMLAMWWLHDTIWAGIWGRGDGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG67</accession>
    <name>D4DG67_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible dual specificity protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019792.1">
        <property type="nucleotide sequence ID" value="XM_003019746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG67"/>
    <dbReference type="GeneID" id="9583715"/>
    <dbReference type="KEGG" id="tve:TRV_06169"/>
    <dbReference type="HOGENOM" id="CLU_049471_0_0_1"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="363" mass="40236" checksum="4341D3E04F3D6045" modified="2010-05-18" version="1">MASVPYYIPNQEYSNAGLNNISDCVHSAMEIAEKCPLAIPIKHDLPPGVYACPEFMNMFSGVQIKPPIHLLDWTYDRRRTAQDVLPYLYLGPNNAMRDAEFLAKNGITLLLAIRDRTRIQAVTVNGDRVAARLGIESDFVEIDSAQELITKLPDIIRRINNHVCPCPTHQPEGHGRTRKVLVFCDTGNDRSACVVAAYLMAMLQTGAAVASSHIQVRRLSTNISPVFVDILKAFEPILDAQRAIARNTLDNHGTSGLLNSGNALSRKRSFQVAEESHNADGEAMAMDLCRPSLPPFRDRRKARPSGGQACVKFAELALSTLNDFMARCSLEARILLFLSLPLNICGSTLLSFSSFFFVYFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGD0</accession>
    <name>D4DGD0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000352">
        <property type="protein sequence ID" value="EFE39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025830.1">
        <property type="nucleotide sequence ID" value="XM_003025784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGD0"/>
    <dbReference type="GeneID" id="9583640"/>
    <dbReference type="KEGG" id="tve:TRV_06233"/>
    <dbReference type="HOGENOM" id="CLU_088027_1_0_1"/>
    <dbReference type="OrthoDB" id="4172893at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="30922" checksum="6CE20B8C0713B44C" modified="2010-05-18" version="1">MPKQTPARSSKKSGPYPSPKRRRALSSQTRVGIAASPSVPEPEPEPEPVRPAAMNTSRMATGASATMASQAANPWQRTATPVYSMPPPLSYTQRLSMPERLPIHPPPSPGTPGHLPSASTPWSAQDDEILLAARAQAHGWNQIQRDNFPTKSSNACHKRYERLIAKRRGSDWNDERVDKVASYYMQLREKTWQPLAEAVGEDWRDVEKLVSQDELVRPLSQVHFSVYLDFYSAAGPRSIPFSRKYRLELEKRLMQDIHSALSGAQGPFSQHWDSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ0</accession>
    <name>D4DGJ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019665.1">
        <property type="nucleotide sequence ID" value="XM_003019619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ0"/>
    <dbReference type="GeneID" id="9583582"/>
    <dbReference type="KEGG" id="tve:TRV_06294"/>
    <dbReference type="HOGENOM" id="CLU_072876_0_0_1"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="242" mass="26457" checksum="4B402746B9A66DFC" modified="2010-05-18" version="1">MGVAISPIQTAYAEAPPHSSSPSKKPMYDVDEEESTNSSIVRKIEKPAAQPATSQPDSASPQAPTLIKTRSPTPTDQLAEQIRHARLFLYRHSLVAENSFNDTVARVLRAESQFTSTIASLAPPRESGERLLPGGIYVLVSAMAGSIVSRNRGILLRTASPIAVGTVAAWSLLPITMRNVSDLVWEYEKKVPALAENHLYLQYVAEHSVQQAIRVSGDARVWMESKIGQGRETLEKWISKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGR4</accession>
    <name>D4DGR4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019573.1">
        <property type="nucleotide sequence ID" value="XM_003019527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGR4"/>
    <dbReference type="GeneID" id="9578378"/>
    <dbReference type="KEGG" id="tve:TRV_06369"/>
    <dbReference type="HOGENOM" id="CLU_050708_0_0_1"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055566" description="NodB homology domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="163"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40195" checksum="0C56D9BCE2212D73" modified="2010-05-18" version="1">MLCRLFTLFITAALACCVAAIPLQGQQSNSIIERTPGRWPWHPHRPRPHRPRPHWPFPKPHWPKPHWPKPEPEPTAVPTMAPEPTTVPPTEPSGTYPPDTTPTVEPTVVPTDVPTTFPSMTPTADPTVAPTGTSVPTGVPTGVPPMPGTIPFGTVINQCTVNGTIALTFDDGPYDYTGPLLDIFAKNGAKGTFFVNAMNFGNIMDYADVIKRMYKEGHMLGSHTYSHADLSKLNSTGIALEMKKLDDILAPIIDGNRPTYMRAPYFAYSDTVSKTMAELKYHMIDANIDTKDYEHATPDGVPISVENFKKGLEAGGTITLCHDVHQTTVELLIQQLLDEIKKRGLRAVTVGECLGDPQANWYRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH71</accession>
    <name>D4DH71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019446.1">
        <property type="nucleotide sequence ID" value="XM_003019400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH71"/>
    <dbReference type="GeneID" id="9577896"/>
    <dbReference type="KEGG" id="tve:TRV_06526"/>
    <dbReference type="HOGENOM" id="CLU_048445_1_0_1"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="360" mass="39765" checksum="1BA8DA009E564E5C" modified="2010-05-18" version="1">MSRNLRSHFDEDAVTNEDLISFREKILGIPRSEQPAIPRPEPKEEEEDFSAINAAIAAFSMSVNQGSPSIANNTNANNTSSAAASSSSASGASTSGLFTNLFDSSNTANASGNSPGMSAPRHSNSAPPSPAMMNGTPAMPAMNASFPMNAGHQMDLNHLYAMVNELSEVLKNNRDLTSGIIKSAEDIARRAAAEGTTPNLQEVNGEISATRIAELERALAREKRRVETLRHEQVENMKLIAEYENAVGTMVEQIRNYCCNNEGHFLSQKRRYNDLLQAERDAHLASRLDRDYWHAQTMKCAEMIRTAYRLRCEEEELPLRIVAGLQNEVRAYRNALGMDPEKPEEEWGWEILKDAPPGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHG4</accession>
    <name>D4DHG4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019339.1">
        <property type="nucleotide sequence ID" value="XM_003019293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHG4"/>
    <dbReference type="GeneID" id="9577661"/>
    <dbReference type="KEGG" id="tve:TRV_06620"/>
    <dbReference type="HOGENOM" id="CLU_010564_0_1_1"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="177"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="723" mass="82346" checksum="746E65C9631F3F47" modified="2010-05-18" version="1">MGEKMASKKKKTRSSGQSSANVISDPRFANIQSDPRYRLPSKKHTHAKLDKRFSHMLRDSDFSKNAPVDRHGRKLARDDTRKQLEKFYRVDDEDDQEEDKDSEEEYISVDDDEEVQKELRRVERAGYDPARDGGFDSSSSDESSSDEEEEEDVAGNMEMEIPGPGQQDADIPTGEYTERIAIVNLDWDNIKSQDLMAVFTSFLPPGGVIRKVSIYPSEFGRERMEREEMDGPPKEIFSHNTKSQDEDFLSDEQDEEEEEEKIKKSLLVEGNGDDFDAGKLRQYQLERLRYFYAILTCSSKEVAKHIYDAVDGTEYMSSANFFDLRFVPDSTDFTDDIPRDECVKLPDDYQPSDFVTDALQHSKVKLTWDADDRARKEAQERAFKGSRKEIDENDLKAYLGSDSSENEEDEAEAAGAAEAGAAPKLSKKEAERARVRALLGLGDKPAAGKKESKPVGEMEVTFSAGLTAAPARDTVFENEPEKEETTREKYVRKERERKQRRKAKLKASRSGEGVSQEEGGGKDRQETKEAEEDLGFDDPFFTAPELDAVKAAKQRKEDRKKLQEQRRAEEEASASKRAELELLMMDDEKSTPISHFDMNEIEKAQKRARKSSKHRKGKKSVVETMPVDNFEMNVKDPRFQSLFESHEYAIDPTNPRFKQTTGMNLLLEEGRKRRRHVDDTGPDEEKSGEKLKKNKKSKSSLTVADDGEAISKLVQKVKAKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHN2</accession>
    <name>D4DHN2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019284.1">
        <property type="nucleotide sequence ID" value="XM_003019238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHN2"/>
    <dbReference type="GeneID" id="9577525"/>
    <dbReference type="KEGG" id="tve:TRV_06688"/>
    <dbReference type="HOGENOM" id="CLU_2607750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="8527" checksum="C7232B11998826AB" modified="2010-05-18" version="1">MGLESTLTGCHIGINPGLVNLGWVDDGLISISDFAYQPKLAISTRQPERSMEVNTAGKRGGAGNSSQKENNLELHLQWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHS3</accession>
    <name>D4DHS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019241.1">
        <property type="nucleotide sequence ID" value="XM_003019195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHS3"/>
    <dbReference type="GeneID" id="9577481"/>
    <dbReference type="KEGG" id="tve:TRV_06730"/>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055871" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="136"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40047" checksum="369A936853EEC637" modified="2010-05-18" version="1">MARLSYLLLASLSVFNGVLASKSAVLDLTPQNFDDVVMKSGKPGLVEFFAPWCGHCKNLAPVYEELGHAFGANSEKVYIAKVDADAHRPLGKRSGIQGFPTLKWFDGKSDKPEDYSGGRDLESLSEFVASKTGLKPRLKKAQPTEVMMLTDSTFDKTIGGDKDVFVAFTAPWCGHCKTLAPTWETLATDFILESNVIIAKVDAEAENSKATARANGVSSYPTIKFFPRGSKEAVAYTGGRTEKDFVDFLNEKCGTHREVGGGLNDKAGTIETLDAIVAKYISGTSFEPMVKEIKEAAGTLSAKYADYYVKAGNKLQENAEYAQKELARLQRILNKGNLTPEKIDDLVSRSNVLRRFLGEEKAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIA2</accession>
    <name>D4DIA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019085.1">
        <property type="nucleotide sequence ID" value="XM_003019039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIA2"/>
    <dbReference type="GeneID" id="9582571"/>
    <dbReference type="KEGG" id="tve:TRV_06910"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="27819" checksum="C7B6AB4D410F63DF" modified="2010-05-18" version="1">MARRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGYDPLRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACGMAVKVLSKTMDSTKLSSKKIEFATVGKTKDGKIYHHLWGADEIDALLKEHDLAKPDDQETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ67</accession>
    <name>D4DJ67_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione reductase</fullName>
            <ecNumber evidence="4 15">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_07233</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 15"/>
    <dbReference type="EMBL" id="ACYE01000425">
        <property type="protein sequence ID" value="EFE38083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018728.1">
        <property type="nucleotide sequence ID" value="XM_003018682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ67"/>
    <dbReference type="GeneID" id="9581147"/>
    <dbReference type="KEGG" id="tve:TRV_07233"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF1">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="7 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 15" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="165"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="514"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE38083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="629" mass="69048" checksum="6C7F5A77C2E100AE" modified="2010-05-18" version="1" fragment="single">ESDAWSEKPPAAKAQTGRRRKRRRPETTRRDSQGPSWSFFFFLFARPCLCPFPAAIQGMPSLPTPPSASTLLSQLGRCTRHKNSLLPPAVISPPFYSSIRRYHIQQRPHSGLFSPLAARNRTLATRKVTVTHSSPRLGAIARQLSSTPASQDKMAPIDMEGVEKYDYIVIGGGSGGSGGARRAAGWYKAKTLIVENGRSGGTCVNVGCVPKKMTWNFGSINEHLEHAKHYGYDVPKNIKYDYGYFKRTRDATIERLNGIYERNWNREGIDLVKGTAKFVEPKVLEIDLMDGSGKKMVTAPHILIAVGGYPIIPDIPGAEHGITSDGFFEIEELPPKLAVVGAGYIAVELAGVMNAVGVETHMFIRGDTFLRKFDPMIQETMTKRYEAAGMHIHRGYTGMKKVELLSPGKGAEKRLKLTFDDGSEMEVNELLWAIGRAPAVTKLGLKEIGVKQKESGHIIVDEFQNTSVDGIYALGDVTGQAELTPVAIAAGRQLGNRLFGPPELKSSKLSYENIPTVVFSHPEVGTSGLTEPEAIEKYGKENLKIYHIKFTDMFFSVFPAEEKEKNPTEMKLICAGPEEKVVGLHILGLGVGEMLQGFGVAMKMGATKKDFDSCVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJC4</accession>
    <name>D4DJC4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000434">
        <property type="protein sequence ID" value="EFE38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018684.1">
        <property type="nucleotide sequence ID" value="XM_003018638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJC4"/>
    <dbReference type="GeneID" id="9580837"/>
    <dbReference type="KEGG" id="tve:TRV_07290"/>
    <dbReference type="HOGENOM" id="CLU_011914_0_0_1"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="3">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="619" mass="69139" checksum="033AAE622C63314F" modified="2010-05-18" version="1">MTRTVTSPPSCSTRTKTQRQHHQQHQQHQQQRDQAPPGLAEPPPPTSASPVPPPPHQAHTHANTHQFIYAHDEPPPKRTKLHHSPPQVSGQLALRARDAQGQSSVVARPHSLPQRHIQTQLVTIRSPRNGDDSPGNRAGGCLSFAKPDATTNSATRTSDSTLVRPTRASLRHSRSTQVDDGDMPLVQRAPGGGEDADMQGVEATTNNEVHLKTPQGPSATTPAGGEKRSLRSHDGGTRPSKSELAMYFPNYEQILSLEPAKQEFLCAETTVTLVDDLTEPITLDHEGLGTSSLPQNPLENLHNAEVVDVGSFEGTDGKDPLDEDTFFKAHRRLERQEKQLRNLEKERAQYEKTQLDHLLGELQGHDWLRVMGINGVTDSEKKLYEPKRDYFVGEVTALLEKFRAWKEEEKRRRIEREQALLAEEDEQSDSQEEDEDDDEEEAEEEDDDEEDEGESGLVEGSSERTSTTAIGSLPDPDDVDRLAAHQLYQEVISATKNKKLKVQKSNQTSQPAKQSKAQPQQQPTGNKGLDSSKPAATYIEPNPWPTGPFLSFYSKPHLRESALKKHKRGRTRMAFGKPLPELVEASFRLPDEILTPEAIRAAQRRNRRMRREDGKPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJK6</accession>
    <name>D4DJK6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_07374</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018614.1">
        <property type="nucleotide sequence ID" value="XM_003018568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJK6"/>
    <dbReference type="GeneID" id="9584543"/>
    <dbReference type="KEGG" id="tve:TRV_07374"/>
    <dbReference type="HOGENOM" id="CLU_006714_1_0_1"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="535"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="734"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="84074" checksum="D27A1FFB90371A41" modified="2010-05-18" version="1">MPGLDKPPQTLYDKVLKDHIVNEQKDGTILLYIVISRDSQANIASQQAFEGLKNAGRKVRRPDCTLATVDHNIPTTSRETYKDVAGFVQESDSRLQCMTLEENVKEFGVTYFGLGDKRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLITKRSKNMRVQVDGELPPGVSSKDVVLHVIGVIGTAGGTGAVIEFCGSAIRGLSMEARMSICNMSIEAGARAGMIAPDEVTFEYLKGRPLAPKYGSAEWKKAVAYWSSLKSDEGAVYDKEVFIDAKDIVPTISWGTSPQDVVPITGVVPGPDDFSDEVKKASCRRALEYMGLTAGTRMEDIPIDKVFIGSCTNARIEDLRVAAHIVEGKKIASNVMRAMIVPGSGLVKRQAESEGLDKIFIDAGFEWREAGCSMCLGMNPDILSPRERCASTSNRNFEGRQGAAGRTHLMSPAMAAAAAIVGKLADVRKIASTIPISQKKSSPKFEIHPEVEDEEELDRILDYPEDNEPHTNTTAEKSPAGLPKFTTLKGIAAHLDRANVDTDAIIPKQFLKTIKRTGLGSALFHPLRYNEDESENPNFVLNKEPYRNAKILVSGENFGCGSSREHAPWALLDFGIKCIIAPSFADIFFNNTFKNGMLPIAIPDAATIQQLAAEADAGHELEVDLVNQRINDAAGNKLADFEVEEFRKHCLINGLDDIGLTMQMESLIRKFEGQRTRETPWLDGSGYLKRQNGNGTGPAMVEAAPVPKTNRGEIKGEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJS9</accession>
    <name>D4DJS9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000444">
        <property type="protein sequence ID" value="EFE37901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018546.1">
        <property type="nucleotide sequence ID" value="XM_003018500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJS9"/>
    <dbReference type="GeneID" id="9584475"/>
    <dbReference type="KEGG" id="tve:TRV_07447"/>
    <dbReference type="HOGENOM" id="CLU_094271_0_1_1"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="227" mass="25465" checksum="1B8030FEFDDF7426" modified="2010-05-18" version="1">MADILTQLQTCLDQLATQLYATLCYLTTYHDHSPAIPPPNVPTAIPQLKKIPKNAPPNTPAAQPASGQAQGQDQKDQTPQQQQQQQQQQQQGGEASGGAQDQNKDLPPRPDSPNTFAQRQRELARDLIIKEQQIEYLISVLPGIGSSEAEQEARIRQLADELREAERIRRRKRKQMKKLAERVDGLLEALIVCICMKTKWPFSGNIVSETEHLKNRQRESDGCCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE3</accession>
    <name>D4DKE3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018320.1">
        <property type="nucleotide sequence ID" value="XM_003018274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKE3"/>
    <dbReference type="GeneID" id="9580022"/>
    <dbReference type="KEGG" id="tve:TRV_07665"/>
    <dbReference type="HOGENOM" id="CLU_885590_0_0_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33218" checksum="79E04A3B9749DE1D" modified="2010-05-18" version="1">MYGGKTALQSMRAKPESDRKNIERNFQAVPITQYAGRWLFLNTTYWDFGSSPDRPLEEPESLTQLYGAGRWTCSFVPSLRAPPGHPLTSFSQTERYLLDYFIEGIGPNCSLSPFYNPYLSLVTPLALSHAPLRNTLLAIAANQFYRLGNVKFEKEAYIYKQRALAGLQKEINERKPSFGAVATVLMLCFHDISDGCTPSWKTHLRGGMQLLNLLPLKTAEGHMLKQFFVMYFVAHDIMGRTAMEDSSEAETLENAWLADDDLEEVRGPSCFLLFSSKPLAYHPGRLICLWAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF1</accession>
    <name>D4DKF1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018328.1">
        <property type="nucleotide sequence ID" value="XM_003018282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF1"/>
    <dbReference type="GeneID" id="9580012"/>
    <dbReference type="KEGG" id="tve:TRV_07673"/>
    <dbReference type="HOGENOM" id="CLU_052897_0_0_1"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="243" mass="25001" checksum="DE816F86885863C8" modified="2010-05-18" version="1">MPAKKAASGKSATHASYKDMIKDAIINNAMEAGKLSSSRLVAGDVVMLTRCSRQALKKYVQNNNAISVTSQATFDAQFNRALKAAVEKGEFTQPKGPSGPVKLAKKETKPTAKPAAKKSAKPAAKTATKKATTTKKAAAKTDKADKADKEEKKPKKAAATTKKAAAPKTPKPKANTTKQRKATSSAPAVVDVPKVLGKTKSGRVTKSSAKPAGAKKAAGTKKKAASSTKGTPKKAAAAATTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH5</accession>
    <name>D4DKH5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7102 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018293.1">
        <property type="nucleotide sequence ID" value="XM_003018247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH5"/>
    <dbReference type="GeneID" id="9579989"/>
    <dbReference type="KEGG" id="tve:TRV_07697"/>
    <dbReference type="HOGENOM" id="CLU_422224_0_0_1"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="340"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="650" mass="72940" checksum="54577E7B08DACC85" modified="2010-05-18" version="1">MLSYDNNNFHQQNTTEESNRGTNTNHNMALDGLNPPNSRTMNHSELHCFVEDDQKGALESIQGIDSAKIPLTRASSELLSYVLRLHKEYMNTNPRTLSHTLLPDWYKVEQLKISSSIPEQGASRGTISALTFLMRDPSNLQTTLEKLNVEPDEGLEFPTLYTDLKDKILAEVAGEKLVCRPTTASLILETLSHEKVRKLEYQKPTYHHQPNDKLENFELCPRIEKSKETNHSSVVKNATNTGRQLLPAVPRGPLLPGLFSASDSVSSFIEAHGKRPPWNNNNMSNSKLHSFANFHNTKVPDQQLQTAEFLIPRKTSPEAGLYTIPLDELPTTISSQKPMVLFLSTDLLRTHGPLVHKLETLSNPPTLIFQDHSTPHSYNMGEGLCLRDADITLSPTVGMLLATTIDFMQLHLPGHSIQLESDIKLNSPFQEKIYRTCKKYDELYIFTLHHADPSTPLVSVKQNTFNAMATIGAFCNSMNIYSKVRVLNVTSDVTNLAHWVINLGKRHQNLVLQSDIERIISGLNGLPPQRHSGASDLEPISSTLDEQFLTQCLALNHFAAALVVHILLPSLEQTQEIDQGLLLTASCPDEESTTFPVSKRLTIGLGRLIDGKPEEKAYAVYLLGERAFSRVRDRRRRMLLSPFVPMLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL54</accession>
    <name>D4DL54_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein Nap1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018092.1">
        <property type="nucleotide sequence ID" value="XM_003018046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL54"/>
    <dbReference type="GeneID" id="9579301"/>
    <dbReference type="KEGG" id="tve:TRV_07928"/>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56721" checksum="5DD28552548549EF" modified="2010-05-18" version="1" fragment="single">PVQPVHPPAILKRIKQKKAAFAVDVRHAKPGFPIRRSLVHAKRKKSSPPKVNLLDKSSTQKKYNNHRLLARSLAPSLPPHATSRTSSLACSTPQNTPANHAPISSHAQQPGIASIKEEGLDPATAASIFAKNPGLVSMIQGKLGSIIGRSSGYIESLPASVRRRVAGLKGIQTEHAKLEAAFQEEVLQLEKKYFAKYTPLYQRRSAIVNGAAEPTDEEVEAGKRDEDEEEDEKKEDEAKQLPVESEETPASGIPEFWLSAMKNQISLAELITDRDEGALKELTDIRMEYLDRPGFRLIFEFAENEFFTNKTIAKTYYYQEENGYGGDFIYDHAEGEKIDWKEGKDLTVRIESKKQRNKNTKQTRVVKVTVPTESFFNFFSPPKPPQDEDDDVASDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALRYEEIEENFEADFEDDDEDDDDEDDDDEEDDKRGDDDEDSDEEVCYPLRLQTMCHTNPALRIERRLKAQEGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLA8</accession>
    <name>D4DLA8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000500">
        <property type="protein sequence ID" value="EFE37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018010.1">
        <property type="nucleotide sequence ID" value="XM_003017964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLA8"/>
    <dbReference type="GeneID" id="9579139"/>
    <dbReference type="KEGG" id="tve:TRV_07982"/>
    <dbReference type="HOGENOM" id="CLU_126899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="194" mass="22517" checksum="62DCFC271F4388C3" modified="2010-05-18" version="1">MAWLGSLSVSDIINYTIPYQIAALSVGLLVVLILLIDHADILLRSRHVKDLYCVTSQTLFKTRFRKKLSGTELENALRYAYNNYTKQGKPFATKADLESWIILLPPKAMKEWCNLPYSHLNFTRYLQDVRYLPNYFWFVVEYSANYQCFVGCCHGVSYPGGLPNPPSRRHGVQSEKTFWLAFFKHPLLEHTFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZQ8</accession>
    <name>D4CZQ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SsDNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025538.1">
        <property type="nucleotide sequence ID" value="XM_003025492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZQ8"/>
    <dbReference type="GeneID" id="9581775"/>
    <dbReference type="KEGG" id="tve:TRV_00300"/>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="151" mass="16814" checksum="F3C86E5721CC10C1" modified="2010-05-18" version="1">MFRQSALQTLSKAARPITTPVSRSFSSTAIRDHARLTVVGRLGAQPEVATSSNGREYVKYSVGTNYGPRDNQQTSWFRVTSFVPEGPGRDHLLNLPKGTLMLVEGDATMRVSEDNEGRKTSMLGFVQREPIRSIYGIFNIYIINDLISFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZW7</accession>
    <name>D4CZW7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025491.1">
        <property type="nucleotide sequence ID" value="XM_003025445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZW7"/>
    <dbReference type="GeneID" id="9581728"/>
    <dbReference type="KEGG" id="tve:TRV_00361"/>
    <dbReference type="HOGENOM" id="CLU_096147_0_0_1"/>
    <dbReference type="OrthoDB" id="4174404at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="27824" checksum="D543C42D6B22D71C" modified="2010-05-18" version="1">MVYPLPTFAKYYKNPEKLLARCVKGHKNGPRLIQPQPPETNDVSKSDPPASLLNSHLPPEELDPEELDNYDNASYLDSDSDNIVIDLEDDDSFHKHSICSYVSVTSDEIVCNLDDGSLMPQLIEAYDMLFPDELEIGIADGTISLDISLEEDDDDDSEEDEDSSSASSDEMGPEDINQDFPRPGIGEKKRFVERIFTWMKRVPATDESELSVSLSEKNPSEKSAESDLKRKSSMSDLHHAYEATEGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D024</accession>
    <name>D4D024_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025357.1">
        <property type="nucleotide sequence ID" value="XM_003025311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D024"/>
    <dbReference type="GeneID" id="9582968"/>
    <dbReference type="KEGG" id="tve:TRV_00418"/>
    <dbReference type="HOGENOM" id="CLU_030431_3_1_1"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50243" checksum="9F8FA6E6B66E4320" modified="2010-05-18" version="1">MAASKQDLSSWDTFQWKRRMERFGDTDEPVIALGPKGEVDGICQLGELTDKGRQTTLELGQRLRHLYIERLGFMPEIISNTDNMYLRSTPVPRALESLQSVFWGLYPSSARTADFATPSIIVRSAAEETLFPNEGGCHRFRQLARLFAQRAADKWNESEEMAYLNSLWSKWMPENSPRVAVDSRPRLSGILDTVASTYAHGPNTRLPAEFYDQKAREVADRIAVDEWFSGGQESREYRKLAIGALMGDVVERMVHVASHKGWRPMAGAYQSGEKSPAVKLALSGCHDTTLASMLASIGAFKNERWPPYTSSIAVELFKDVSERGASGSPAGAILEEFSGPPSQKPASEKSSFFSFLTGKKSQAASSSGVARTPQVNQPALSNHYVRIRYNDKPVTIPGCAANPAKHLPGDKSFCTLEAFKEIVDKFTPANWREECGLNLDKGMFPDGEEQPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D058</accession>
    <name>D4D058_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025391.1">
        <property type="nucleotide sequence ID" value="XM_003025345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D058"/>
    <dbReference type="GeneID" id="9581627"/>
    <dbReference type="KEGG" id="tve:TRV_00452"/>
    <dbReference type="HOGENOM" id="CLU_095741_3_0_1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="158" mass="17638" checksum="40F3FE46AC4E54F0" modified="2010-05-18" version="1">MSYDNGARVERKGAYMLLWSTSAEFLYHWGILIATSETGGTLFHQTYNKEMWNLAVEIRNITRSRSLLCALKLGDVEDCSGTWMNAIEACLRQTKVEGDFTCRTWALAAAFELADGGFIGMEPSWDRIGKIETEAKFLAGDSWQSGTVHVEASAQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D059</accession>
    <name>D4D059_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025392.1">
        <property type="nucleotide sequence ID" value="XM_003025346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D059"/>
    <dbReference type="GeneID" id="9581628"/>
    <dbReference type="KEGG" id="tve:TRV_00453"/>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="29625" checksum="9F6E18DB846A719F" modified="2010-05-18" version="1">MMKLIVWAQDRWSSPYNKSLRYLPFGLCLKIGPRVMANEANALRLVERHTQVPAPQLIGFAKDGLGDGYLLMSRIPGVPVDAVYYRMTYEERAQLTKDLKDHILQYRQIRNTSPYLICNTLGGPTYDHRTDTGDVWGPYRTKDEFTNMLTEGLEDLRDQPPLSALYKKHHRIFFTHSDLHYSNLFIHKGRLCGIVDWECASFKPEYWEFTRAVWSFMADRQREQNYRLAFVENYEEELEAERLIWSKNPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0B7</accession>
    <name>D4D0B7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025332.1">
        <property type="nucleotide sequence ID" value="XM_003025286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0B7"/>
    <dbReference type="GeneID" id="9582943"/>
    <dbReference type="KEGG" id="tve:TRV_00512"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="47287" checksum="D8EE1FDC327A3F8E" modified="2010-05-18" version="1">MTEAKPHTPERVRVAICGGGIGGLTMAAVLRRLDISYVVLERYAQITPQGAGISLAPNCLRALDQLDIFEKLAKHSQAMREVHIYKNNEFWGSQKFGMTNEAFGYYVHKIERHQFHHLLLEATGGNDVVRLGFNVNDIVDEEDAPYAIVRAEDGREVHADIIVGADGIRSYTRRVLAEKSGMKATNNIRFTGRVHMSGYTKPLTHLTTKDEGVGHWMLYDDAILTTWPCKDNRQWFIGVAAAKLKPGEQPDRSVWKGATKDTINEEYGERFHPFGEESKMKSIIDASERVIASNVFMELDVPHMVKGRIVLVGDAIEDAVELGNALYEHFRLNDPTAFDRYSEVRQKRASDLVQFSDNFAKVHTARLPYGLGPLVRKILYKYVPTSIWVWYFTWLFNYQPVIKYPLLDLPAGQAASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0K6</accession>
    <name>D4D0K6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000034">
        <property type="protein sequence ID" value="EFE44624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025235.1">
        <property type="nucleotide sequence ID" value="XM_003025189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0K6"/>
    <dbReference type="GeneID" id="9580728"/>
    <dbReference type="KEGG" id="tve:TRV_00601"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="540" mass="59156" checksum="476725A7CE7A4F06" modified="2010-05-18" version="1">MGQCYKEISAAARKRRDDALAAFWSIPDVKEDELPQDLRSYPQTSGLLTAEELEIINSDASVLLEKLRTRKLSSVTITTAFCKATVIAQKLTNCVTEVLFDEGLKRAKELDDHLERTGKVVGPLHGLPVSLKDNFMTVPHPSSIGMAAYTIEPTVKDSVIVTGLRDLGAVFYVKTNVPTAMLMAETDNRIWGETRNPVHKGLSPGGSSGGEAALLALKAAPLGLGTDIGGSIRVPGAFCHLYGLKPSFGRFSTLGGRAAIQGQEFIPSVCGPMATSLDTVKLFCETILSEQAGQWNADPKLLPIPWRKDVIQPKGRKLRIDILGNNDGGMTCYPPIERALNIVSKALKEAGHDVFEWAPTGHTEVLRLVMEGFKVFGTSAILPQLEKHGEPLFKCMEKTFSTLKEDQLDAVKLSDMIIERNGLQRAYLDRWMATKTDTAGPMDCIIAPAAVAPAARLGYGETVQYFGFTAFGNLLDKAVDLKRDASWNPLNEDDKIMQSEYDPEFYHGAPVSLQLYGKRLEEEKVVEMVEVVADVLKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0T7</accession>
    <name>D4D0T7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025157.1">
        <property type="nucleotide sequence ID" value="XM_003025111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0T7"/>
    <dbReference type="GeneID" id="9580650"/>
    <dbReference type="KEGG" id="tve:TRV_00683"/>
    <dbReference type="HOGENOM" id="CLU_022271_0_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57069" checksum="13E9D16495548EAE" modified="2010-05-18" version="1">MAYSGPDEPASGYLDDSTSQIELLLGSEDDGRAFARLKEHGRRRAWTVQRCYRCLENLLRDLILHQRRRFRCRASSPAHTLWLLLKILIFLVGGFVLVSLVQAIFHPSYQRPPEHYAQLQRRILASSEPGRANQRNEKIFIAANIIREDLIRGAWGASLLELVDLLGEDNVFVSVYENDSGKATSEALIELQDKLPSYLAEVRNRALRPLDATYTPTSAESEKGFRHATEKFDRVLFLNDIYFSATDAVQLLFSTNAEKTGHADYRAACAIDFTANVMFYDTFVVRDNEGYGMGLMFFPWFPVVGKSESRQDVLAEKDAVRVRSCWGGMASFDAQVFQKSSGNHSELALTFRHEPEPFWEAAECCLIFADMESTSLESNGAGVYVNPYIRVAYTENTWVWLGFFRRYERIFANLQWIVSKIGYPEYNPRRLHNPGQMVKEKVWVQGDDEDQLGSFQMLERKAAVGGFCGQRRMFVMKDDINDANKKGEKNWEKIPIPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0X0</accession>
    <name>D4D0X0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="8" type="ORF">TRV_00716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025058.1">
        <property type="nucleotide sequence ID" value="XM_003025012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0X0"/>
    <dbReference type="GeneID" id="9580570"/>
    <dbReference type="KEGG" id="tve:TRV_00716"/>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="518" mass="56856" checksum="45218617D13FCA1E" modified="2010-05-18" version="1">MLQVLDQLQVPHVERYIPVSTAKEGWHVIKEMHVRGAPAIAIVAVLSLSIELTELMDHDKLSAEANEVEAFILEKLDYLVTSRPTAVNLSDAAIKLKALVQKRKQIGDPKGKDLAEAYVEAAEKMLIDDAMDNHRLGDFGAAWIMNNTPVGKDGKKVGVLTHCNTGSLATAGYGTALGVIRSLHASDKLEHAYCTETRPYNQGARLTAFELVHDKIPATLITDSMAASLLAQKGTGLAAIVVGADRVVANGDTANKIGTYQLAVLAKYHGVKFIVAAPRTTIDLRTKEGEDIIIEERAKSEVTRITGPRISDLGRNEENITLETVNIAAPGIDVWNPAFDVTPYDLIDAIVTEVGVAEKNADGLFELEKLPILFFFFLLLLLLLLVVVFGYFVSVFLFRFNRSKKTIYLLLYAQVSNAVTLNGAGSGLGIVEAIPSPGATRRSRSHYIRPSYLYIFLSLTRMSPWSLNGWLFYLVAGFFLARNKLGGTSTKLISHVTESCSSHDFEREMHFASPLELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D141</accession>
    <name>D4D141_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025050.1">
        <property type="nucleotide sequence ID" value="XM_003025004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D141"/>
    <dbReference type="GeneID" id="9580542"/>
    <dbReference type="KEGG" id="tve:TRV_00788"/>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="684"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="942"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135854" checksum="A6B08AE99A02A671" modified="2010-05-18" version="1">MAPNKKKKKAASNPARGFATVSVPSKVKPSASSEPVGPEEIAHKPEALAEKPPTGDGQNDKAAAQTASHKPELHELTPDELERHLEEAELQIIVDKHGTKCKGDAARYSTKMVAERRLLRPQASQLENVSDWLSPDLLNKILEKEKVEAKRQPVISNKSAEYNGQLGLATEENTCVNLWILQLTLSTLGFQETDIHEALKGLLLHGPLEIVSGKDPIQALDLAFYYLALYLDKEKLALYDENKPTEAVGKVVTVGDDSISILSERIASGSSSPAGPARSNTPSKSTEATSTLLSRPLSPDSEGDSGIHDPEMLIPEFLALRSRLYELDPSVFNKTKSKKGVKQTSKQIQDPGQDPAITIIKRKISRIEQDILFDSHEAEERWAGTLEELRRTTGEILKNTLNLPASTPGTPRTESHGTEVKDARPEEDEGIFGEMFDSELNDTGSQTLLGSQNTSTKSRDFGNTVGVGPRKVLDDFCHSRDTNVILTYHKLSDNAFLHRHAIEISWSKDQDIMFEAPLKDISYRISPRSLVIDMTGISAASDVQAESYISTVALFIISSHAWKDNKAFIKLSGVWKEVWDEISLEKKEHDDQIDRQVIKTFKGYIQEYEAHIEEDVVLVHNFRQRYGTGDVTPSTEGTPKRYNADSFSPELRALWHSRSSSPNFQRMAAARAGLPIWSFRDQIIDALSSHQTIIICGETGSGKSTQIPSFILENELAAGKECKIYVTEPRRISAISLARRVSEELGENKNDIGTNRSLVGYAIRLESKFTASTRLIFATTGIVIRMLERPQDFDSVTHLVLDEVHERTIDGDFLLIVLRRLLSARRDLKLVLMSATVDAKRFSDYLNGAPILNIPGRMYPVETKYLEDVIELTHYRPNKDDSYTDVTDDTSEDEKSGASEDTTTLKSTLTNYSRQTQSTVISFDEYRLNYKLITDLLSSIASLPELIDYSKAILIFMPGLAEIRRLHDEILSIPMFQNGWVVYSLHSSIASEDQEKAFVVPPPGIRKVVIATNIAETGITIPDITAVIDTGKEKVMRFDERRQISKLVEVFVARANAKQRRGRAGRVQEGICFHLFSKYRHDKLLSEQQTPEMLRLSLQDLILRVKICNLGDIEGTLSEAMDPPSSKNIRRAIESLKTVKALTGTETLTPLGKQLAKLPLDVFLGKLILYGAFFKCVDAAVSIAAILSSKSPFLNDINRKSQIEASRKAFERGIHILTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K6</accession>
    <name>D4D1K6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024882.1">
        <property type="nucleotide sequence ID" value="XM_003024836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K6"/>
    <dbReference type="GeneID" id="9580373"/>
    <dbReference type="KEGG" id="tve:TRV_00957"/>
    <dbReference type="HOGENOM" id="CLU_027088_1_0_1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="522" mass="56972" checksum="7310CC7D373A6F02" modified="2010-05-18" version="1">MSVSVALNTPLADALNEVVQPKLVELGWSTGGGDDSALAEYVILMLVNGKTQDQISAELANDLLSLGPEDTEAAEFSKWLFDQVETLDRRLNGGSKERAHQEQLPQAIPSFSEETNGGNGNATPTDVPVPQQDMVMDDGVGPGIDASVPTGPRNARNQKQNGRGRGILGQLSRAMDRSNESVLHRVRNQQGTERINSHRDNSRGGRGSRGGHRASMGRQMGSNVPMGMGMGMNMGMGMNHNQMQNMGQQNMMNITPQQQMQMMSMFEEQARMMSQLIPGFVAPAINPAFQNGPPQQAQGRSLFERAEFQPGRRNQQSPQTTAADVEMDGSESKPAEEQPAREAPGPDTVCRFNLRCTNKDCPYAHQSPAAPEGASVDVSDNCPYGAACKNRKCVARHPSPAQKAVHQAEEICRYFPHCTNPKCTFKHPNMPLCRNGADCSTEDCKFTHLQTPCRFNPCLNRTCPYKHVEGQRGAFTDKVWRADGAKPETPHVSERKFISDEAGEEELIKPGSTPSNDAGIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2C6</accession>
    <name>D4D2C6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024613.1">
        <property type="nucleotide sequence ID" value="XM_003024567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2C6"/>
    <dbReference type="GeneID" id="9579939"/>
    <dbReference type="KEGG" id="tve:TRV_01231"/>
    <dbReference type="HOGENOM" id="CLU_1209551_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="222" mass="24746" checksum="A72399FA67D79161" modified="2010-05-18" version="1">MDNQEQGDINDSQSPGQLLDRARTKLLAEEMALLKSLTMFSDFTRYEPPIGGRFPKETYDNIISAIQAILTSMDLMALATRNLERMSGYSPATDVVDDNSPGARRRPSRTAASRHQIAEGERWIQHLAEAANSPEFRSGVITSVLYHLSAAVTNCLCLPPYLAPPHPFPLARRLRHINEDLLKFKNVENPSFAAIIAIEVLSSMVSSNLKTLMRFALPFSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2K8</accession>
    <name>D4D2K8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024483.1">
        <property type="nucleotide sequence ID" value="XM_003024437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2K8"/>
    <dbReference type="GeneID" id="9579711"/>
    <dbReference type="KEGG" id="tve:TRV_01313"/>
    <dbReference type="HOGENOM" id="CLU_054590_0_1_1"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="189" mass="21341" checksum="A9461780EB33F071" modified="2010-05-18" version="1">MSTSDAERKYRVFIPDFFDGSPADIAWYPPDTDEKKEKWGAFFKDRAPPPNTLPRIPQVVEEINKNHCPGGAGFKSWGIVGYCWGGKITSLLSAKDTLFKAAVQVHPAMIDPKEALEVTIPMCILASMDEDPNEIEKYKDNLKVEKLVETYGDQIHGWMSARGDLKNPTVKKEYENGYKSVIAFFRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L4</accession>
    <name>D4D2L4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024489.1">
        <property type="nucleotide sequence ID" value="XM_003024443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L4"/>
    <dbReference type="GeneID" id="9579706"/>
    <dbReference type="KEGG" id="tve:TRV_01319"/>
    <dbReference type="HOGENOM" id="CLU_1027413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="271" mass="32616" checksum="1DC59172051FD6C7" modified="2010-05-18" version="1">MMMKTIDRDREERERDRQRRTSPCKDVEGEEGEKKRREEEEEEEEEKLLKIERLEIEVEDQKKKKKKKRRKRKKKKRQKKAKRAKKRQKKDRKSDEPVFDGDFLGDFWVVRYAQAQLASPQEQAWQVTLEAAIHSQYQIKYDIRWNRRGDRREDRREDRREDERKRRKEEEEKKGYWVKGSMLAEVKRALAAAVMRPSTLSRLVHGPLSPSPAPLRDGRILAFSFALLLSCLAIFQGHPAPFTEYVLTYTYIQIQRQKRKDKKKKRACLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2P9</accession>
    <name>D4D2P9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024524.1">
        <property type="nucleotide sequence ID" value="XM_003024478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2P9"/>
    <dbReference type="GeneID" id="9579747"/>
    <dbReference type="KEGG" id="tve:TRV_01355"/>
    <dbReference type="HOGENOM" id="CLU_113770_3_1_1"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14154" checksum="B21876004C72AC07" modified="2010-05-18" version="1">MNICSTISVPLPTHRLASSALRALQVDLELSPLVKRTFRLTNPESSSIITRQNEIQVNRTAGEPKTGQAATDDNVDVSDESLTVLETEYRATTNRMLRVAVNAFMDSLGVVVGVMEELDVDVLGNELGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2U4</accession>
    <name>D4D2U4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024437.1">
        <property type="nucleotide sequence ID" value="XM_003024391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2U4"/>
    <dbReference type="GeneID" id="9579659"/>
    <dbReference type="KEGG" id="tve:TRV_01400"/>
    <dbReference type="HOGENOM" id="CLU_025524_5_1_1"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="2">
        <location>
            <begin position="109"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="413" mass="45515" checksum="EC1D761159C710B9" modified="2010-05-18" version="1">MDKEIQLAELPLTQLCAICRTCSLACSKRHKLWSQCSGIRDPAEYLKRNELATPAAFDKDFNFLTGIERSLERAEVDAEARGIDLVPNSDPDGGKAKQRSDMARGELPLQRGMENSGVRIVKAPKGMTRNKLNTSHWHRKRRCLSWAVEWIFPDGQKTITKCLENTSVGTALTRVPLVKELGFASRLNDEKITEPPAKKRKVSIEKIVRDGAIDPVEASTVTSCTLEGSVSVEENGDPAPDDVSSSKTLSPGPALPSANESEPPLTPLPVALTSTAPPAPEDNPLTNNDGSSTQLHIYLHRPQTCAKVPVLIPVTDQSLALGAVLRDRTVLEFPTFYVLEHSPDQISGEKYLLEEQYVTQYKDDIDPDGSGEEGEIDEGEESEEAKRLAELNALKVMEVLRRDLEENVASYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2U8</accession>
    <name>D4D2U8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">TRV_01404</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024441.1">
        <property type="nucleotide sequence ID" value="XM_003024395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2U8"/>
    <dbReference type="GeneID" id="9579663"/>
    <dbReference type="KEGG" id="tve:TRV_01404"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="276"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="450"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="468"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="485"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="613"/>
            <end position="614"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="619"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="694" mass="77517" checksum="72BEFF8C6EF46D50" modified="2010-05-18" version="1">MAQVDTLDMLVLAVILVGTIAYFTKGKYWAVVKDPYASSYAATNSAKQGQTRNIVEKLEETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADLEDYDYACLDKFPEDKVAFFVLATYGEGEPTDNAVEFFQFITGDDASFEDGGSPEDQPLSKMRYVAFGLGNNTYEHCNAMVRIVDKALTKCGAKRIGDAGEGDDGAGTMEEDYLAWKEPMWKALAEEMGLEEREAIYEPTFSVIEEADLNTESENVYLGEPNASHLKSRGQGPYNAHNPFLSPIVESRELFSVKDRNCLHMEFDIKGSQLNYQTGDHIAIWPTNAGQEVDRFLKVFGLEEKRHTVIRVKPIDVTAKVPFPQPTTYDSVVRYYIETCGPVSRQFISQLAAFAPDEETKKKMIRIGEDKDVFSDKVSAFYFNIAQALQSFTDKPFTAVPFSLLIEGIPKIQPRYYSISSSSIVQKEKISITAVVESLRVPGAGHVVKGVTTNYLLALKQKQHGEPNPDPFGLTYAISGPRNKYDGFHVPVHVRHSNFKLPSDPSKPIIMVGPGTGVAPFRGFIQERVHQAEKGETVGPTILFYGCRKSTEDFLYKEEFEEVSKKLGDSFKLITAFSRETSQKVYVQHRLKEHAELVSDLLSKKANFYVCGDAANMAREVNVVLGQILAEQRGLKPEKGEELVKHMRNTGSYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D394</accession>
    <name>D4D394_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024274.1">
        <property type="nucleotide sequence ID" value="XM_003024228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D394"/>
    <dbReference type="GeneID" id="9579410"/>
    <dbReference type="KEGG" id="tve:TRV_01553"/>
    <dbReference type="HOGENOM" id="CLU_2489566_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="87" mass="10619" checksum="E9ACDCF7E612C75F" modified="2010-05-18" version="1" fragment="single">TLVYPWRRTKRKNIGPLPSRANFFPHFGDFDKLTRKAFEADFLFFFFFFFLLFLLLFFFALISPSPSSSLLLQLHQLHRPYRYLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3X6</accession>
    <name>D4D3X6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024022.1">
        <property type="nucleotide sequence ID" value="XM_003023976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3X6"/>
    <dbReference type="GeneID" id="9582715"/>
    <dbReference type="KEGG" id="tve:TRV_01789"/>
    <dbReference type="HOGENOM" id="CLU_2252012_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="104" mass="11993" checksum="0437CDC20B5C8F0A" modified="2010-05-18" version="1">MTEYKDIEGSEVLPIKPLTSSKQPFGCGTRRNWKHIATLTIDLATIRNIQWMYDIKANLSMSGIDMSSVYLPRPCRDSSTKNAMHTKENIYQKHTYQPSKDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4J1</accession>
    <name>D4D4J1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023811.1">
        <property type="nucleotide sequence ID" value="XM_003023765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4J1"/>
    <dbReference type="GeneID" id="9582386"/>
    <dbReference type="KEGG" id="tve:TRV_02008"/>
    <dbReference type="HOGENOM" id="CLU_044089_0_0_1"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="15">
        <location>
            <begin position="254"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="53773" checksum="962A114770F53F69" modified="2010-05-18" version="1">MCSYQKPKTLPVGGLYRTGLLSIWILLFLSLFSIINKQLTTDQDSPLLKTTFAIISLQQQLVWLIFFAFIPILLLHHTYNKFTTTTTTTTTNMPASVHSNEPVDEIVVTKVVEGFAAPVQEPVAAPAVDAPAAVVDGPVEAVKEVTVVETAPIVEAAPATVQEINDVAAEPVSAPVVTADEIFEKPAAPAPVEDAKEKELESGYASGSGSAAANEEPIPELIFTKQHLQFLNQRLQFLEPQEVLKWCVTSLPGLFQSTSFGLTGLVILDMLSKLDIPRHQQVDLIFFDTLHHFQETIDLRDGIQKDYPHLTLHVYKPQGCNTAAEFAAKHGEKLWETNDELYDWLAKVEPAQRAYRELGVTAMLTGRRRSQGAKRGNMDIIEVDEAGLIKINPLANWNFDQVKEYVSRRNLRYNALLDRGYKSVGDWHSTQPVAQGEDERSGRWKGQAKTECGIHNPRSKYAQFLMEQERKKQEEEALKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4N4</accession>
    <name>D4D4N4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023854.1">
        <property type="nucleotide sequence ID" value="XM_003023808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4N4"/>
    <dbReference type="GeneID" id="9582466"/>
    <dbReference type="KEGG" id="tve:TRV_02050"/>
    <dbReference type="HOGENOM" id="CLU_060785_0_0_1"/>
    <dbReference type="OrthoDB" id="4219700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="37048" checksum="AF1017563D20DCFB" modified="2010-05-18" version="1">MLEIPPPPPPKPRVVLPWSEYDPGLLNGDGVAVRKCSTDYLASIYKTCLDTYRPNEVNLSPEEAERLTESVRHELTRLTSHPDLFPTPTAHERFFKLLQESVARVVKKRQDKENESIEESIRLRANILAREEEEILQEINRPSFKPGLKPWEQFLLKGSPGSGVVLPPDPPNGYVQMMPIGGVALHLRWLRENYTASKEYAEASQITQFLSNPPSADSSTEARDPEETISLTPNPYFEVRMVCLNISIYLDDLTPFKRRMPIPKHDRVIDRLESFNALIVRTNNDKERLEGEEPTNYNGDPSGVRAMLYRTIVEDIPDNTEENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D500</accession>
    <name>D4D500_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023661.1">
        <property type="nucleotide sequence ID" value="XM_003023615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D500"/>
    <dbReference type="ESTHER" id="trivh-d4d500">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9582208"/>
    <dbReference type="KEGG" id="tve:TRV_02169"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005126462" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="31"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="564" mass="61495" checksum="3567866410883901" modified="2010-05-18" version="1">MWSLLTAAVLFARLSIAVPTAAAPAIEKRAAPTVQLDYATVVGSSALGIDSFKGIPYAQPPVGKLRLKPPQPITGDLGTVQATGLPRACPQIYLKSDDIPDDILGRFINTPVFQKITHAGEDCLTINVQKPSSATPESKLPVLFWIFGGGFEFGSTQLYDGTSLILRSMSQRRDIIFVAVNYRVGGFGFLPGADIKNDGSANLGLLDQRLGLQWVADNISKFGGDPEKVTIWGESAGAISVFDQMALYDGDNTYKGKPLFRGAIMNSGSVIPADPVDCPKGEVVYEKVVEAAGCSKATDKLDCLRSVDYTTFLNAANSVPGILSYDSVALSYLPRPDGKALTASPDKLGRSGLMAKVPFIIGDQEDEGTLFSLVQNNITTTEHLVDYFSTYFFHGATKEQLRDLVDTYPNDPSAGSPFRTGNLNQLYPQYKRLAAMLGDLVFTLSRRVFLDIANDKFPEIPTWSYLGTYGHIIPILGTFHGSDILTSFGYTPGIPSTSIQNYYLSFVNNLDPNKGTPLGFPKWPRWGEGKMLLNFEAVKNSYLKDDFRADSAKYLEEHSDILHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D559</accession>
    <name>D4D559_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023654.1">
        <property type="nucleotide sequence ID" value="XM_003023608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D559"/>
    <dbReference type="GeneID" id="9582200"/>
    <dbReference type="KEGG" id="tve:TRV_02229"/>
    <dbReference type="HOGENOM" id="CLU_2051363_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="120" mass="14316" checksum="583373C34723B37B" modified="2010-05-18" version="1">MAGQGMKGYYQREKKRRRRRRRSERRERKRKRKRRLMMFKDEAEEAAEAAAAEEEEEEEEKGETTWWKLSSFSFLRPSLERYTLTRRLLSSTNSPPAGLPLACCWPLLLLLLLLFFSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5G8</accession>
    <name>D4D5G8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023591.1">
        <property type="nucleotide sequence ID" value="XM_003023545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5G8"/>
    <dbReference type="GeneID" id="9577063"/>
    <dbReference type="KEGG" id="tve:TRV_02338"/>
    <dbReference type="HOGENOM" id="CLU_069412_0_0_1"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37861" checksum="B011D5562D816C8D" modified="2010-05-18" version="1">MELITIPFSEVQTALQEAKEAWADTDKFNTHGHSFEDINALVPETQNLKHIKPGLFSTLYQHWVSLIMSSQGAEEWHTFELPRYLAFETTEMYQVWIARMSSRPSIFDGLVEMFPKQSLAGVKTEEIFGRHRKWFLRLDSCSTKDGENGMKPITSVHDLIRQLCTSMRGRRAILDTLEDGVSKPVVYLVPYNEQMDPSREFRVFCPPPGNGIAAISQYRWTSPFSVNNMEDAVKVANRVHLDSLQIHSRIMETARHLPDVLVHEMMEREGFTFDVLSVPDGSTQLVEINPFGAMSGCGSCLFHWLKDSKSLYGLTGNIPVKLALPDSLLDANAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5N2</accession>
    <name>D4D5N2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000125">
        <property type="protein sequence ID" value="EFE42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023451.1">
        <property type="nucleotide sequence ID" value="XM_003023405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5N2"/>
    <dbReference type="GeneID" id="9583478"/>
    <dbReference type="KEGG" id="tve:TRV_02405"/>
    <dbReference type="HOGENOM" id="CLU_022271_0_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="581" mass="66034" checksum="045476757C8EE28A" modified="2010-05-18" version="1" fragment="single">PLLFCSSQTASSAQESLIDEERRQEERRRETRRTSRVLSDVHWPLTGMSGSRDSCDSDAFILDDFDYLGDGDGDGDGERARGDGYQRTNRSRYGYSYSYSYLLDGSTAWSSRILRLLPPRWRRKFAARRHSKPASRLSPSGTYRRTLRWLVTASLCLTAAVALLWPSYTHRPAHYNELKRLAVGSETPGRGNPRNEKVFITANIYDPDGSLAQSQWSRSILQLIDLLGPENSYLSIYENEMNEQARGALQRMADETPCNHSMVTEEHLDTAGLLHITLPDGSRRLKRISFLAEVRNRALRPINQAGMPRFDKILYVNDVFFDPVDALQLLLSTNLAEDGGATRYRAACAVDFINPFKFYDTFASRDLEGYSMGLPFFPWFTTAGNGQSRRDVLSQSDAVRVRSCWGGMVAFDAKYFQNQHQHQHQHQQHNTTRFRAEPDLLWEASECCLVHADIQDPPSAGGEPSADTGIYVNPYIRVAYSPFTLSWLGVTRRFERLFSLPHDIINRLVGMPWHNPRRTEKPGDLIEERAWVENERGEGSYQTVTRAAGTGGFCGNRALQVMKPHPQPGEKTWELISPDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Q2</accession>
    <name>D4D5Q2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023441.1">
        <property type="nucleotide sequence ID" value="XM_003023395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Q2"/>
    <dbReference type="GeneID" id="9583461"/>
    <dbReference type="KEGG" id="tve:TRV_02425"/>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="528" mass="58956" checksum="982B006F4419E040" modified="2010-05-18" version="1">MASLLNLEGLGVRNEAGPLEDRDGGSGLLTLLHSNSPGHIYSAGCCSGSEGWSCLSRVAWLLSIFDPIAGDEVDVAGLAVGNVTRRSPFLPPPKHAPDPPPPAAPSHPQPRPAYITPNPPAFSLPFLPFFHSVIPLRLLFLLFAFFFFFFFFLTVPGANMISFRKCVVIAFFILSGIFLLHTAHIKPTLAKAEPGTHRQRSEPQNARLTTKLGSKADSTSEQEPEQVSEPEPEKEPEPEPTTLRGRLKYHFPYGVKAKFPGYIWQTWKYTPADGEFDPMLRPLEASWTELHPGFVHQVVDDESAIYFLKYLYSSFPEIIEAYESMPLPVLKADFFRYLILHARGGIYSDIDTTALRSATDWIPSTFDRSTFGLVVGIEADPDRADWAKWYSRRIQFCQWTIQSKPGHPVLRDVIASITEDALRMKEEGILTKKGMDKSIVEFTGPAVWTDAIFRHFNDPLAFPSEDGKHRNISAHHFTGMTKQKQVGDVVVLPITSFSPGVQQMGSEEADSDMAFVQHEFSGMSTYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Q8</accession>
    <name>D4D5Q8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023447.1">
        <property type="nucleotide sequence ID" value="XM_003023401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Q8"/>
    <dbReference type="GeneID" id="9583467"/>
    <dbReference type="KEGG" id="tve:TRV_02431"/>
    <dbReference type="HOGENOM" id="CLU_004869_0_0_1"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="689"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="972" mass="109611" checksum="EE2977FF9172E5B9" modified="2010-05-18" version="1">MAEAWHDVESDDGDIINNSSFGSNSNSDGEAEGGLEVDVISLPSVEDENSSGSESDISRNWVTVMDTFTFATSTQVALPIRAKICNLEGRQKQIPFSVLLKNPELRHLGSNQSPTSDLYVTAQLWSSCKPLGMPMQTAYKSFKTTRTWNEWLEMPVLIRDAPQNTQLALTVWDLSPLGGEEGHDHSVPFGGTTIALFDEDGTLKKGKQKCKLYRHKAADGFSYTTTPSTPPPKRRKGNFVEEGPTPIELELERLEKLLKKHEMGEIPRVDWLDQLVFRAVEKIKIEAEDAAKKRALRNKAAREKAVVEPNGDSGVSSQDDEEENFVLYVEFPRFDFPIVFQDFEYPPPPVSSLAQHTPSGSTVALKPPPEVRLGPDIEGAADDEGNYPIIRIYDPEVGQRGNPCEDKHRRLVRSHRTGIMDRDLKPNPKIRDEINEIMSYGPTQELNAEEKDLVWKFRFYLTRDKRALTKFVKSVNWQDASEARQAVEILPKWTEIDVDDALELLGPLFDNPEVRAYAVDRLRKSDDEELLLYLLQLVQALKFEAIPKSSTDETNEAAHDSSLTNFLISRAANNPILGSYFHWYLMVECDDTAPGTLSTHRKFFASVEFYFMLELEKVNPAQRKVLLRQGELVTILSKIAKDIRFARVNRPFKIEMLKKFLGDPKNDILQIDPPLPFPLDPTVSIVGCHPEEANVFKSSLSPLFINFKLLDGRKYPVIFKVGDDLRQDQLVIQIITLMDRLLQKENLDLKLTPYRIIATGATAGAVQFVPSTPLSAATAKYKGSLLAYLKANNPDDSEPLGVRKEAMDTYIKSCAGYCVITYLLGVGDRHLENLLLAPDGHFFHADFGFILGRDPKPFAPMMKLCKEMVEGMGGANSPNYIQFKQYCFTAYITLRKSANLILNLFSLMVDANIPDIRVEPDKAVLKVKERFHLEMTEEEAIRHFDELIINSVNAIFGAVIDRIHDLVQGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z4</accession>
    <name>D4D5Z4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023415.1">
        <property type="nucleotide sequence ID" value="XM_003023369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z4"/>
    <dbReference type="GeneID" id="9583435"/>
    <dbReference type="KEGG" id="tve:TRV_02517"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="575" mass="61857" checksum="97FADF6E04E40865" modified="2010-05-18" version="1">MTSFEATALGNAPHVDDDELFINDVNLRDARDGQRKDNGGGRERLRLEEEIPSENEFRTTGLRLFLILSSLLVSVFCQALDDTIIATAIPPITDQFRRLSHVGWYGSVYLLTNCAFQLFYGKLYKIFPLRWVFMSALFIFELGSLVAAIAPKSETLITGRAVAGIGAAGITSGAMTIMAHTAPVRWRPTFTSMIGAVYGVASVVGPLLGGVLAEKASWRWIFYLNLPLGGASAFILSLSLKRLPPSAGGQNLTVAMTVKRLDLVGTFTFIASIACLLTALQYGGTTAPWSSGLVVALLTIFSILLATFILAQVLQKDENATIPTHIAKNRNVAFGAFFAICQGGAFNIFIFYLPLYFQVIKGANPIRSGINYLPLILVNTIGIIISGLLTTKLGYYMPWIWFSSMTMPIGAGLLTTLTVDSNPSQWVGYQLVFAIGSGFGLQQPFVTAQTSLPLEEVSTGMAIMLFSQLGGGAIFVPVAQSVFLSELVTSVGRAGIPGLDPHQLITLGATQFKQIIPPADIPKVVLAYNSGLQQAYKVALVLACVSIIGPLGMKWVSLKPATQKENPGIADLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D605</accession>
    <name>D4D605_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000130">
        <property type="protein sequence ID" value="EFE42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023332.1">
        <property type="nucleotide sequence ID" value="XM_003023286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583351"/>
    <dbReference type="KEGG" id="tve:TRV_02528"/>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="883"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1872" mass="208609" checksum="DC3453FA6B715266" modified="2010-05-18" version="1">MVLSELSKGMHSRDLKQGNVETGSIRSASGSTHEPRPKSASTAPSQSSAASSSYRACLLSVHDENFSREDVLFNRQALGDWAVKVGDLIELSALYGEPPSDSQLEGESTNITNSQQEEPGANPTRGQSGGGTGTGGRYSPLPSHRDSCRGDGALPNSSHAVGNFLFIVKHMQPEILNRHPNLQISVSNQVANRFGFKKRSRVLLTVKPRSQCSATHVELVFRDQFLLRADMWRMAMSELLDRPLYKGQKIVFMNTVKATVKSIFQDGRKVMAGYFTPRTIPIFRSESARYVLFIQMSKEMWDFNTEGTGDILFSRVVDGLLPELFKRWATIDAHHLVTIVMFTRVQYDHNIPASDEFIPMNLSSSSLNPNTTGEAGASVQDFYRVVVNDMPSGRWTAILDELKREFRTFLRDILIPSPQTSGDEVSELEGSPPIATAGTSPTIAGHLTSAIKGNILEAINIASSYLDFEYVGRDLVRTGTSIVMITPGSGTFEVGFDTLALTSDVLGSRSIGIDLICLSPMPLHSVPLFKYKIPKRRSSHSSVSTINSDTASIVGPSEVASPTSTKTTIAAWPPTPKPTHLSDTLSRATQSSSAVKTSLNPEEWGYGIPYWIDISFWGAHNYQDKKWKKNNVTPPAFGTVAPQPKLFQPKVRMYEIQMMGVMESEQSNISIPNLHVGHSVIDETAVRPRSSELGTLNSSSNLASHTSSHKPQTRDRGQPGSFMYSFKDSKKLIMSSQEKKRTNISEWMDSYDELAFHVRSKKRPSKRHHKPKSPSLSNLSLSSRRAHQQQPRTPVRQKSSTTLVPARPAAISPISTVSGTNLAKGLPTLPTASKSNNKSNLKDTSKPSTSRSTRSISFALLGFGRAPPTATASTQVKAEYAKALPTASGKTPDENIYDPKPEDHPQSPSSLTPAIAEPQAQHGDEGSRSELLPSRPISIRTAVSHNPEEPSVAAASLDGSFTAHVPELRHEPGSLYESHAAGLKRTGRRLDMANNSISGAGPAFPSPEKALSPWIKHVKPWNPPKHLPTRESWFGRWHHVYPRKPTTSSVNWKSLKSPAALPLTTEDFPTEEELETNYLQKPYTVYQDEDSDVSESPKTRDALLREMISLRLSHGFQLVLRNQRDDLTFGDTIFDLSALSKDNVTIYMSMGGIIHRLVCVGGGEIEVTQFTRKPLNGYLQDAKELEVAYRPAVKTIQGTQYRKSCIRLALSQLEYNWNFADSFLAGHRDHLADSLRQLKHWRTRFVLIPTHMSTHSRRSNSSLNEDNEEERHLMGIYQLTQVWQRYKYTPPEEKKFQSTSSKKKDQNPLNILYQTCDPSVVVATELDRLLLEDPGLDNPPAQLLPESELLQKSSVSLSSIAQAMQSEKGVRMMDRRWHWRLHYNCFVGMELTTWLIKNFSDIDTRDEAVQFGNELMKHGLFHHVQRRHNFRDGNYFYQITDEYRISRPESKGGWFQSLKGDKSTPGTPMEKDGVRDSPSSFRSRSEKSSDDGGGRNEPLPPPPRSSGRGKVAIWLAKSMKYDLDPRKRSDRPEIIDLHYDRIHNPENCFHIELSWMNATPKLVEDAVVSWAGLAEKYGLKLVELPLSEASSIVESQVFRRPFPIKLKHQPPDPPSGNLFTSTSFTSQSTPDRHFYHKAILKKFDFILDFEPFSAFPTDVEVSYSWGKPDYRFPQYVHRSGAILAQITDEGNFLLLTNRLFNTYHPSVMIKESNKFERGEYFRPRASTIVDSALYDRGSPHLSPVVRSSGLNGFSPSVSPQTQQQPESINVYQTAADLKDKLQAFCNDKEKLDAFFATAAAHVQPVSTKASPTNTMTSDSLIPSLVLPDSVVRHSTSSSAGKMPQRSASIDSVVVQHTPRYGPAHDSPGTTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6F1</accession>
    <name>D4D6F1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitotic spindle checkpoint protein (Mad2B), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023213.1">
        <property type="nucleotide sequence ID" value="XM_003023167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6F1"/>
    <dbReference type="GeneID" id="9583233"/>
    <dbReference type="KEGG" id="tve:TRV_02676"/>
    <dbReference type="HOGENOM" id="CLU_050394_1_1_1"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="26604" checksum="C70533789601514F" modified="2010-05-18" version="1">MAESSRPPETYAALASAFSSFLAVSIHQILYLRSIYPQSTFLSVRQFNQPVRQSRHPKVCSWVNDACAAVETQLIKSTVTSVAIVILSVSSNKAVEKFTFDLSQIPQVAPGDIHTPFASSRQQQQREGMSIPQVDLEAQFRAVLHRLTAACGRLAPLPPDEEYLPTLHMVLGPDADAPAGMDKDDQQWIAAEPEPERIRYGPGCSQAKTVPVRAIDAGEMKLEVWIEEARDKFDVDNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D749</accession>
    <name>D4D749_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022941.1">
        <property type="nucleotide sequence ID" value="XM_003022895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D749"/>
    <dbReference type="GeneID" id="9576967"/>
    <dbReference type="KEGG" id="tve:TRV_02928"/>
    <dbReference type="HOGENOM" id="CLU_1367118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22042" checksum="B3F70D8A0DDDF2FA" modified="2010-05-18" version="1">MYSSYLGASPASPCLIGRSRTATKKEEAQPRRSKKKVGPPAVFSRPSSGLFLFWATRDCLLKRPETCLTSSTPAAAGKAQENFAFFLSARKTRFSLLLLLLFFLLFLSLPLPLLLSSVYSYLPLLLLLLLLLQLTVSSLFLLLGSVACLLALAAAALVSSRLSLLLIASIYPSKQDLSRCYLSSWWVHRSNNNNINNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7C2</accession>
    <name>D4D7C2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000156">
        <property type="protein sequence ID" value="EFE42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022865.1">
        <property type="nucleotide sequence ID" value="XM_003022819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7C2"/>
    <dbReference type="GeneID" id="9581592"/>
    <dbReference type="KEGG" id="tve:TRV_03004"/>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="280" mass="31756" checksum="1D79FF1FEFC61A73" modified="2010-05-18" version="1">MKEGLEAKALRQFDALVERGDVIYSHRDPVHVPTKPFNIQFRIASSLTKKPQIPIKDAEKKPPVNKASPFANDPPEFVIEHVGPDHTLRLNKFCVVRTQFILHCNEFKPQIEPLEAVDLAAGWSVLTRMESEYLLIYNGGLQGGWSLPHRHMQLLPRPPRDVHNLFPDIYGIENGRVPNIPFQHVVRRLPASATAEEVYETYTDLLAAAGVDENDYSHNLVLVKDWMMIIPRSRASQEGIKIVNAAAMVGMIWIPSDEVLDLWLQSGNPMETLARYGKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7G7</accession>
    <name>D4D7G7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_03049</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022825.1">
        <property type="nucleotide sequence ID" value="XM_003022779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7G7"/>
    <dbReference type="GeneID" id="9581549"/>
    <dbReference type="KEGG" id="tve:TRV_03049"/>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="65"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="216"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="697" mass="77137" checksum="35101C55FC3AA67C" modified="2010-05-18" version="1">MSKLAIEASSEDDQYDVATKIVCLECGVDKVEDCPPKAAEVVDKLMKAPTFSRKEEVKAWEQELVPCEHTIGLQQGSNQGIRIREPSKCYGCDLQENLWLCLECGTVGCGRAQFGGIGGNSHALAHSNEKSHGVAVKLRSITPEGSADIYCYTCNDERTDPELAQHLSHWGINIAEQEKTEKSLTELQIEQNLKWDFSMTSNDGQVLNPVFGPELTGLKNLGNSCYIASVLQCLFSLPEFKARYFKPNEEPPSSSAPAEDLETQLRKIADGLLSGRYSVPDPAAAGSTSDVVYQRGLLPSMFKHMIGRGHPEFSTMRQQDAFELLLHLFKIISVSTHSASDPNPVESFRFAVEQRLQCTSCKKVRYKVDEQDNISVEVPAIRLNHFMPGPGTDQKWETVPLENCIDLFTREEHVELTCSGCGNKQFSKQTLFKTLPQNLIVNARRWEVVNYVPMKLDIPVVVGNEPLDLTQYLSKGKQEDEEVLEDEPESAAPEFVPNSDAFAALCGMGFPENRVKRGLFSTGNSDQEAALNWILAHMDDPDIDQPLVTGAGSASGAQKPADGDDKINQLADMGIERDRAEKALGATDWDVTRALDWVFSHPDEPLEPNPTAATNSSGPSGSIPGSSEKPALFDLQSIVCHKGTSVHAGHYVAFIRKQVPPEKEPRWILFNDEKVVAEAGDIKEMKQFAYIYIFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7J8</accession>
    <name>D4D7J8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022784.1">
        <property type="nucleotide sequence ID" value="XM_003022738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7J8"/>
    <dbReference type="GeneID" id="9581519"/>
    <dbReference type="KEGG" id="tve:TRV_03080"/>
    <dbReference type="HOGENOM" id="CLU_151395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="100" mass="11363" checksum="64FB727C3726D2A3" modified="2010-05-18" version="1">MKTGVLRKVQDSPESCHFCPDEEHSLWDCTSADERYATAEKATFTFDQGELEFQEANTPNEEDRSEDPMESREPLGYSSIGISSLFFFSLLLNCRISEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7J9</accession>
    <name>D4D7J9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022785.1">
        <property type="nucleotide sequence ID" value="XM_003022739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7J9"/>
    <dbReference type="GeneID" id="9581520"/>
    <dbReference type="KEGG" id="tve:TRV_03081"/>
    <dbReference type="HOGENOM" id="CLU_068528_0_0_1"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="211" mass="23847" checksum="60B2352185A5B2BB" modified="2010-05-18" version="1">MWREEKEVESSEEEEEEEEESEEESEEDEDEGPVKEEMTREQRKAAAKARKEAAIRKKRQVAAEPGDLPPSDSEEDEDDDDMPANPNHTAKARSQAAKAATAPADGAASAAKKTDVSQLSRREREALQAQQARERYLKLHSEGKTDEARADLARLAIVRERREAERARKEAETEEREEREREKAKEREAREAKLRAAALGPAANKKKGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Q4</accession>
    <name>D4D7Q4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022756.1">
        <property type="nucleotide sequence ID" value="XM_003022710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Q4"/>
    <dbReference type="GeneID" id="9581446"/>
    <dbReference type="KEGG" id="tve:TRV_03138"/>
    <dbReference type="HOGENOM" id="CLU_026803_0_0_1"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055384" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="94"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="57289" checksum="46E0D0F93ABC7840" modified="2010-05-18" version="1">MVSSLIYSLCAVSGLLATTVNGLPKKGHRSETSLPIVKQTKCGSHTYQYNGLVGYGTVPSNAVDKYGDTLGGFGSSIAIEQASWKKNSDGTYEGIAWAIPDRGWNTQGTLNVQSRIQKLSLKLTLAPSATVSNPSDPNLEIKLLDTLLLTGPDGTPMTGLDADFSGNISYPGFPGMPVATYPGDGFGGSGAGGRRISLDSEGIVIGNDGAFWVSDEYGPYVYKFSREGRMLQAIQPPDAYIPRRNGKVSFSAASPPIYEPDRQTDPEDPETGRNNNQGFEGLAISRDGKTLYVLLQSALNNDGGPKKRYRKQARMLEYDISGTTPKYTHEYVVTLATFVDPHEQDPSKVTITASQSEIHYLPTGDFLILSRDSNAGRAAEYTESVYRHADIISKSAQTTDIKSKSNDKADGSIASSEGVLDDGINPLDYCSFVDYNLNSELGKFRLHNGGAQDEHLLNEKWESLALVPVDPSKEFEDDGKNEYFLISFSDNDYITQDGHLNFGKFKYADKSGFNVDTQVLVFRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Y5</accession>
    <name>D4D7Y5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000165">
        <property type="protein sequence ID" value="EFE42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022659.1">
        <property type="nucleotide sequence ID" value="XM_003022613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Y5"/>
    <dbReference type="GeneID" id="9581317"/>
    <dbReference type="KEGG" id="tve:TRV_03219"/>
    <dbReference type="HOGENOM" id="CLU_032488_1_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="544" mass="61359" checksum="F5A99555382D3B8D" modified="2010-05-18" version="1">MNSNSVNMPQSELKCNICPRKPKFSDVSHLLTHVSSKGHLSHYFKLQVRSQQEPQAGELLAAYDRWYKQNKLANLLSDRMLAKEARTGKGSRASNRSSLPVAFSHQPSTTVAPPTNRNAPITSSPRRGSLPSFLDPQLSQNYYTYDAQGNRISGRTYSPMSVSSMINPNPQPGYGWHQQTQYQPQTTLQASSVQTVWKDGDETESDGEGSPLMARRMRRASLLHPSLRFVRRSISPDPFIDDDAAYEYDDQEDQSQRGSDEVNRLKGVFWPGMDIFDSATEEMRRKRNQKKDGSIIKQMEETSESVEPTELVFSPNGTLRKQRVISGMVDDSSPLKGETPISKTKVTRPRRRPMSQLSGNVQMAQNRYRMRIREQSRAAQLEKLSQQALLLGGHGDPMNYPPLDTHRNALFNTSKYGLENSANAPYYGPFKPPSTEAYRGKENIDPMFSHERNVQKQQYYYGYPSQNENDNYGYSTNPLSYAASQQSCDSGSNRAGIRDTMTVDTRDLFGQQTPGVFQNASPKSPVAEMGHDDIARMYFNGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D845</accession>
    <name>D4D845_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022623.1">
        <property type="nucleotide sequence ID" value="XM_003022577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D845"/>
    <dbReference type="GeneID" id="9581282"/>
    <dbReference type="KEGG" id="tve:TRV_03280"/>
    <dbReference type="HOGENOM" id="CLU_069188_2_0_1"/>
    <dbReference type="OrthoDB" id="4196148at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25380" checksum="EA762FBA67A107A8" modified="2010-05-18" version="1">MSNVHTPPPSYGESAQTPAPPPLGRPELSPLTLDGNLIYPVVPPTTALYELTHELDAGYRKIGISRLCPNRNTAQHGNVREKHIYDFSQPIFSSSVEITGKRKSCLSAALCLRMSRGIIKRGWELFRLRLNGQTDDLIFRIRPRHSPEKQETLQWEDANQSLVAIETVCIPGGSNVRPVFHIVCDMDDRFIDALITAWCAKIWIGHQFSAAAMRDPEGDMGASRTFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D899</accession>
    <name>D4D899_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000172">
        <property type="protein sequence ID" value="EFE41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022536.1">
        <property type="nucleotide sequence ID" value="XM_003022490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D899"/>
    <dbReference type="GeneID" id="9581113"/>
    <dbReference type="KEGG" id="tve:TRV_03335"/>
    <dbReference type="HOGENOM" id="CLU_460185_0_0_1"/>
    <dbReference type="OrthoDB" id="4173308at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="600" mass="67401" checksum="DF775E2AAB0F8BD9" modified="2010-05-18" version="1">MATKGRHRDKWHHWASSPRHAPTSTVRSLVSRMKSKLSPPDSTKMGAADSICEEPSPRDMSTCSKGEIETSEESPCVEGVPSTPAISTASSSVDIGNSTMVSPFSPPDRACSTTPSEERCTKQDVQGSSGSPSPSADVDGDDVFGPSEPESQGEPEDDQVPEETGEIGNAAEVEVGSNEKVPVEEDLEEDLDYATDTGASSEFKEIPREDSVDDEGYSDKEADEGGKKEDGGNEVQEEEEEMIPSREVDFLLENAEVTRRNDLAALQDEFDDEIRYLANERNQLLTEKMFWQTKFVTAIKGREKQRSRASSLTEDNSRMDAINKMLQREMGLIQDIIDKQYKEMSEIKSNCLGTVAQLTQACEVTKTYIDKAKEENMKTAKELAILRKVVMKIRQPSKKLTEFSMHHDFKQALEVNQELKSKTEAQQEELDKLQAQLAERDAKIENLQASNTKLEEQLDDLETFNSKYMNKLEEASRSLTYYQKSLLQARDKETQLNDRLATALGEWASKKKKFKNELLECRAKLQLKDTMINALHGQSSIYLENWKETINMLSEKSRGDELSVKLADCLQETLDRNEALEIELGELREKTLTVLNQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8F9</accession>
    <name>D4D8F9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022445.1">
        <property type="nucleotide sequence ID" value="XM_003022399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8F9"/>
    <dbReference type="GeneID" id="9580992"/>
    <dbReference type="KEGG" id="tve:TRV_03395"/>
    <dbReference type="HOGENOM" id="CLU_012074_0_0_1"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="853" mass="93684" checksum="79334B5B1CDD2003" modified="2010-05-18" version="1">MTATPGTTKARKPSTKGEGSSVVPRKRRRRAVGSGAADDCFTCASRQVRCDRRRPYCTPCLDMGRQCSGYKTTLTWGIGVASRGKLRGLSLPISGAKKVTQSTEPRSVPTQPAEAKAAEKSRPVQKETEPAPTQTPTPNSPWSAINLTPPRSTSSSGSNSSITGSVAGSISMTGSATTSEPTYANLAAYNSTYSPIDACGLPLYRAVPEPLNINTSTSTSTSISISTTNTHGTSGTSSTSTYVELGSPYGSPYSATTTHFSPLEVYSTPVTQKRHIEEELDESETAVSSDVPIYNANTNNTYHYQPYPTASFSLSQPFSTTWIGRNPRMRYLIGYYTEVIAPVIVTFDSPNNPFRLYLLELAKDSEALQHAIAALSLSNLRQRRRNWGLLSTGKTDPSRRSLQAHCRMTERAFEEAFGVTTPEEQLREESYHKGMAIRSINAQLADPVQRRTDSVFATLLMLCLFHMCDTGLASFRSQFAGVKKLFMIRGAGRDRGSQDSDVMKWFMRMFTWFDTMTATINDRDSQMNGCLLEVTTSGQDEWALENLAGCDPRLFRAVAQLGRLNQLSQAKPVDNSTARMERPVPTAAIPQSLTHYPLPTTSATRSTNTANTSTPPLVDMPAIPVSQLDPRTEFWREWHVVRQKLESWRLPDLPGAHAHAHNHNLTHSPAPSLASTISTATTSTTSTPTSTSLFTAPLPASPLSHVNPANLPEISNISESFRYSALLYLERLAHPTTPSRHPRFQTLVSAALHYIQAVKSDVFLLWPLFVVGSECMGEAERAIIRERCCDIQRDSGFVNNLSCLQLLERIWQEEDPNESGSGAPPSGELLGGAAFRWRRIIDSQRLTDEYIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8J8</accession>
    <name>D4D8J8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000178">
        <property type="protein sequence ID" value="EFE41824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022442.1">
        <property type="nucleotide sequence ID" value="XM_003022396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8J8"/>
    <dbReference type="GeneID" id="9580990"/>
    <dbReference type="KEGG" id="tve:TRV_03434"/>
    <dbReference type="HOGENOM" id="CLU_1363336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21985" checksum="7EC32B1CFD6B32DE" modified="2010-05-18" version="1" fragment="single">MHDSQDAILRSQYLDFLFITNITPRRPPYIATMPSPRDSSAHWESHLTDVAPCHFPRLGASPSGPKRPMTIKVALDQTQALKELCESNTATLPAALRAAWSLVLRYYTGAEDVCFGYQDATTTAVLPVARLAVEDDTEMSRLIETALIEYEDSLPFHGDVPSSANGPVGHRLYNTILSFRSAAKVGTAPPSRAANMALPED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8P3</accession>
    <name>SCONB_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sconB</name>
        <name type="ORF">TRV_03480</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022416.1">
        <property type="nucleotide sequence ID" value="XM_003022370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8P3"/>
    <dbReference type="SMR" id="D4D8P3"/>
    <dbReference type="GeneID" id="9580963"/>
    <dbReference type="KEGG" id="tve:TRV_03480"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000397257" description="Probable E3 ubiquitin ligase complex SCF subunit sconB">
        <location>
            <begin position="1"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="592"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="663" mass="74769" checksum="11057FDC385F4F79" modified="2010-05-18" version="1">MDTDNSTLPTEQSAVRETCDRDVTMSPRKRRRLSVSLEPELTEPEAAGTPGERCSTADTPESTASEPRSLFNSTPTEGNIAPFLTKHIKDQHASRNRFAPIDSSLPRRKADSKYCYRHRPDLKCRRQAAEPTVDQMQRDLSTLSQNDQQSIAHFWSLFSAAPSKHRNLMLQGIVAQCCFPQLSFLSASVRDLIRIDFVTALPPEISFKILSYLDTASLCSAAQVSHSWRALADDDVVWHRMCEQHIDRKCEKCGWGLPMLDRKRLKDTKRQVQLRAAGKEIAPNQRPQQQHRPWKAVYMDRFKVGTNWKYGRCTTTIFRGHTNGVMCLQFDDNILATGSYDATIKIWDIETGKEIRTLRGHESTIRCLQFDDTKLISGSLDRTIKVWNWRSGECISTYTGHQGGVLCLHFDSTTLASGSKDNTIKIWNFHDKSTRILRGHADWVNSVKLDTASRTVFSASDDLTVRIWDLDTGKCIHSYAGHVGQVQQVLPLPREFEFKHQSNCADDRSDRLSGSESPDHRGSHGYGSNNAPDQQPNTSAPPTEPMSPLFEALFTEDQGRPAPPRYMLTAALDLTLRLWEVHTGRCLRTFFGHIEGVWGLAADTLRFVSGAQDHMAKVWDPRTGTCERTFTGHRGPVTCVSLSDSRMATGSEDSEVRMYSFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D946</accession>
    <name>D4D946_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022233.1">
        <property type="nucleotide sequence ID" value="XM_003022187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D946"/>
    <dbReference type="GeneID" id="9576835"/>
    <dbReference type="KEGG" id="tve:TRV_03636"/>
    <dbReference type="HOGENOM" id="CLU_015534_1_0_1"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="796" mass="85288" checksum="E6A9A16C3C68A427" modified="2010-05-18" version="1">MDMRLTSTPSILISDSAAEQIPARHRYSSTRNSASSGSCISSSTGRHQAQPSYSDSTPPSPSYGPMAIPRSQETIAPPPLPPPRFIEELANGHDSGWRWGNTFHPGGPGVSGAAAGPAGTEMDSRDTSTSRDTAAGTMLPPINPGSSLFGGGHARPPLRRRDETFRLDADEQRAVDARRPGSASMSEHETALGPRSAPLIGSYGDGNAFSPTSPLTRPSRSLSQTGSLSRTLDTRILPSTRQKPLSEKSVEHSINAYDRNLLSKIGGPASPPRNAVLGLTTTPRDPTRVQTSFSALTLTDETLSPQDIRWGSGPPSAGISPGTGGSGFSDYIAFRNQREGSSSGLSPMEVDQFSQAREKYAGGISSGPVRYGEVAHSLPLHSGRRSHDRSFFPDLDTEMSMDEAHSSSVHSKTTRQRSLGERMPSYAEGISPLSNHGMKRRASSPPQVARHEDAALSTSSADRRMSGFPFNNGICTSPGGARYQSSHGSISSISSASMRTGSYASSTGLSVGASSMSSYDRPSPGGISPTDVDHYDRGGLMSSPAQKQSTSAPILSMPRPAQYPEPSPTSAADMKKNSVSAGSGRKGSHTCPNSSKNPQRVGRSYICDCCHTKPKKLDSLEELRAHEMEKQYNCNYCHKRFKNKNEAERHRASLHIRHHSWSCGSLAGYESAFHPSSSSSNGQASGSTTSTHDTCGFCGMEFPNLPAPQWDVRIEHLTSVHKFGECNQSKKFWRADHLRQHLKHIHAGSSGKWTNILENACMREEPIADPGLPSIGETPDGKMETDMMGHDGDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D979</accession>
    <name>D4D979_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000187">
        <property type="protein sequence ID" value="EFE41600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022218.1">
        <property type="nucleotide sequence ID" value="XM_003022172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D979"/>
    <dbReference type="GeneID" id="9579103"/>
    <dbReference type="KEGG" id="tve:TRV_03669"/>
    <dbReference type="HOGENOM" id="CLU_1344111_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="204" mass="23321" checksum="8CD5152778A00592" modified="2010-05-18" version="1">MIKKRKRREKEKGVGWKKKRKNEGEEEAKKMLLHSKMGETREICKEAANAATVQRDQVSSSPGEEEEDEPEQLTAPSMQWRSRCFDTGRQLKTKPGKKRGRGEPAGAPKPEPATALLRPKQTDRQPLTAETSRVSTPQVNRRPVSRSPRARRRRVVESRKVEEALLLSMFVSSLDFRRPRPSAFRPAQGKKRRDPRSCDVPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B5</accession>
    <name>D4D9B5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022182.1">
        <property type="nucleotide sequence ID" value="XM_003022136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B5"/>
    <dbReference type="GeneID" id="9579053"/>
    <dbReference type="KEGG" id="tve:TRV_03706"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58441" checksum="29200ABEA85C436B" modified="2010-05-18" version="1">MAEPGSPAAAAAGNQAAADQSKVKQLFNFTQIFFFSLTFMSSWESMALNLTAVFTNGGPRALAWGIIVVVAGGLAQSASMAEMASMQPIAGAQYHWTHYLAPQKHRKFITWMQGWITWFAWVSLLAGVANTTATMIQGLVTVNFPDYQPERWHLTFIIFAMLIVEGLMNMYTFWLIPWVELLAGILHVVLFIVFVVVLVSMAPRHTPGWVFGDHSSSSGWNNEFISWNLGLLTPTWGFVGFDGAVHMSEEVRRAKQAVPRSMVWTVATNGVLAYAIIITILFTMGPIDGVLKSNFPIIEICRQATGSVKAATAMVSGLLIISLAVNLASIASTSRLTWAWSRDGGLPAWFSVIDQRHCVPVRAVWLSIVIVMVLACLNIASTTAFGALIALSTIGLFSSYFIAIGCMVIARFSRDRPLELGEWNMGRYGLAVNIFAMFYTAYVTIWLPFPSLLPVSAQNMNYSLPIFAFSTLSAILYWFIRGKKHWAGLNKEVIRLVVERAEEAISSIFHLLYFQKVSSISAVDGRIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9J5</accession>
    <name>D4D9J5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022101.1">
        <property type="nucleotide sequence ID" value="XM_003022055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9J5"/>
    <dbReference type="GeneID" id="9578985"/>
    <dbReference type="KEGG" id="tve:TRV_03788"/>
    <dbReference type="HOGENOM" id="CLU_095067_0_0_1"/>
    <dbReference type="OrthoDB" id="5421247at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="261" mass="28898" checksum="F82CC6DEDF2D3649" modified="2010-05-18" version="1">MPVSPAPATAHAEKGIKGKTSDFSLPLLFSFLSSLTYQPEKAAKMITTPTFAEMEDTARAVILCLKKCPDLAHTKVAIIGGAAICRYVAERQPTDDPELTEEQDVDFMITIPNAEVAHRRLLQAFDTMFTEYEGCLYYSHPGGKQIKVDFSTNCRLPYMPMAATIVRDVDINCLPYIGPTDLLVLSIRLCGQRNSEYSHIDRDSADAVALAETIVKEGPVVLSPIQRQVIREELAEVVHWGPKDETWWRGVLAAALSSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9K6</accession>
    <name>D4D9K6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022058.1">
        <property type="nucleotide sequence ID" value="XM_003022012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9K6"/>
    <dbReference type="GeneID" id="9578942"/>
    <dbReference type="KEGG" id="tve:TRV_03799"/>
    <dbReference type="HOGENOM" id="CLU_428226_0_0_1"/>
    <dbReference type="OrthoDB" id="4173149at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="444"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="639" mass="70879" checksum="2F6B480DED240342" modified="2010-05-18" version="1">MDSVKSSDGRGGEHASAPLSKFQQLVQQRTEQILAERRAQEAHRADMERARLNYKPQQSQRFQQMLKDRVQKALAERKVQPSFQSPISTESDCGGDSERVASSSPLSLDNGTLEEKSSTINAVEGHGISPEIVATSVTETILPTRGHKEPEKSDQSPQSPQTQQDKPSTILLQPQTSNQQRARVPHIQPRSATDPGELEQSPSPHQNTLGTKRRMDSLTTVAIYQHSNEDSNGAIMQLAVPETQEAQYTKAAPAAQETSEPPTKRIKKSTSPKNNPACTCSISTKCEVAAANGVKDCRAIARGVIQKSISRSKSARSNSEILEILSLIKKIEARTDLERTIPRLRDRIHFLELYEIPESSIESMKAKFLDLNNGLPAIIRNHNSIPWDIRLDCSAILKRMEEGNFHVDLSRGILTKRTFRENGKSSVSRVLDKNYPFKQSAFVVGDRHLRNGQWFPWQICALRDGAHGEIEGGISGNKVTGAVSIVLSSSGGGGNQMYADVDQGDTVWYCGTRGKNGEVSANTALLLQAAGRKSDIRVLRSSKLPKVNPYRPSEGMRYDGLYKICSYEILDQETALHRFKLERVEGQTPIRYKGPEVRPTAREVEELRKAYRHNAESKPAKEPKMKQPVAAPPVVEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9K9</accession>
    <name>D4D9K9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022061.1">
        <property type="nucleotide sequence ID" value="XM_003022015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9K9"/>
    <dbReference type="GeneID" id="9578945"/>
    <dbReference type="KEGG" id="tve:TRV_03802"/>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="533"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="753"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="808" mass="90266" checksum="4924994CCDB4CC1B" modified="2010-05-18" version="1">MAAQSTLRRPEDPLVILFRHYSQLLLSRVRNSSRTVKLAATVALLLSIIGTGYGGYSWWKDWSKERVQGRQLLRKNSGLRGKDGSRIIYVPYKSSLTSSSTSKVTIHPTKSTTFDAHRRLFLNPPRAAGLRDGYGGAPPPSTKPGLNLAFLHQLLSLLSIMIPRWNSKETGLLLSHGVFLMLRTYLSLVVARLDGEIVRDLVAGKGRAFIWGILKWCSIGTFASYTNAMIKFLKSKVSIAFRTRLTRYVHDLYLNDNMNYYKLGNLDGAIGQGVDQFITQDLTLFCSAVASLYSSLGKPLVDLIVFNYQLYRSLGPLALTGILSGYIGTASLLRGHSPPFGKLKAVEGKKEGDFRSLHSRLLANAEEIAFYGGADIERVFLSKSFANLQRWMEGIYKLKIRYNMFEDMLLKYSWSAFGYLITSLPIFLPAWGGAGGILEMATPGAGINRERGRMKEFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRVHANSYHQPRGSQIELYSLSDVQGTIHSGFDGVRLENVPIVAPGLFPQGGDELIESLSFIVHSGEHLLISGPNGAGKSAIARIIAGLWPVYRGLVSRPRNFGQDGIMFLPQRPYLSTGTLRDQVIYPHNELDMRESGRTDNHLMEILEAVHLGYLPAREGGWNGRKEWKDVLSGGEKQRMAIARLFYHDPRYVFLDEATSAVSSDVEGLLYERAKERGITLITISTRASLKKYHTFNLTVGLGADGMSWEIDRIGTEKEKMGVEKELQELRRQLDNVDSLKARRQEIEDELQRVWEGEQETVALASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S5</accession>
    <name>D4D9S5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022007.1">
        <property type="nucleotide sequence ID" value="XM_003021961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578891"/>
    <dbReference type="KEGG" id="tve:TRV_03868"/>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1364" mass="149955" checksum="6D7999A50FCAEA88" modified="2010-05-18" version="1">MKTATMTTTTTTATATTTGTRQRLSKATARPLSYSPSLPFQEDELSLPNFTLPHSATEPNIRSRAKSVSRTLGRSSVFGSLRSLKSMDDDQNSTRTRSRSTSSNEDDLPIMREAGNSRVHKLQQLQHHNSNINNNNNNNPPLVNRSFGIKVLHHGEVQTAGAMWRKRSHYLVLTESHLVRFKSQSKAAEVFPSIPSSWGRSAGAAAASNRLSMVSLASLHENQLTGGAAALGGGGEGGIGIALNNIIAVHRLDDGKPYFSVEVCYVDEKNPRGSAIHIQFADPQEAQLWLMGIRAAAETAISIEPPVFDDDTINYVTNVLEQERDYDPGCFGLYRVVHRMSTKQGNRASTDDITKLASNTCLLAIGVHKIHILPTNTKSSNRASMASLVELDLDACLGIMALSSISVQASDDTFQLIFRIPFKSPSIVNLSSSYSGEIALFLRQRAEYLRPGWIHQPFAFNVPPHVQARVMPPLTFEEDYGCFDRTLIAYCAAYDVDTSKIRYMVDYHCEDAPAFQLLPREGCPDGGGYLLLELLAVFRALRYNESFATISFARVNLDILQQMRDPYGPDFDAMRTRSNVAVHIPGQEEIASLTQEVRALALKSRTLQRMDFSYCLTRSAKAAGGERDPGCGIPEAVFPLCRRNLTRVDWLALNGIELGDSDLDYLVDAASQKASALRAFEANNCGLQVHDLNLILSTLRIQKDTLKCLQISNIVGRLSPDQFQQQAGCLRNIRKLELSQVLRTSKSEPLLSAETLLNWELEELCLNNTTVNEQTVESIAMYLASPESKNLRELHLNQCGITGGDVATLLYFMVDEELKPRDIHLHVNDNRLAIDCDLMFASISQNRTPTHLTMRSIEFQRDEDFRHLVEALVQNNTLRYLDISRLSIPHDAGAETSKALQRMFEQNSAIQELDISSEQAHLDVSRFGIGLNLALTGLKKNNTLKVLKIEHQKLGVQGANTLASVIEENNSLVEIHCENNEINLQAFTIIVNAIQKNKTLLHVPSMASDCKRSLARVQREMEADVKETGLRSSLSTASSIRRSVRAAFSGSYSSSGSSNSGGNKLVKSHPSVSQGGASPGVRRASSATLGAMNCVQPGMVASATVPQFTRPEIKFAIEALQNKWNIQEARLQRYLYRNYNMLHGYVDQAVGDDDTKSEGRPATAASLATFLNQLSLAPVEDMSQRDGTSVAAETPSSDASALSRSASFKTANNYIIEDTDTSKDDIGAVDFNLDWSFSQPCSKQSALIDRVLPGSGFSSQSHIQTDELAVPVSTQPRPALLRPTSSVRSSNSTSSVSIKTNTSMTMDRALVNGRKFGTTRTPSLRGMLTARSTSKRETQKNSDLLGSSNIPPQLDWNLPDINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA23</accession>
    <name>D4DA23_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021937.1">
        <property type="nucleotide sequence ID" value="XM_003021891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA23"/>
    <dbReference type="GeneID" id="9578820"/>
    <dbReference type="KEGG" id="tve:TRV_03967"/>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="252"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="59031" checksum="EAF1B447A4340112" modified="2010-05-18" version="1">MSDDDDFMQDSDQEEYDFEYQDEDDDDSGDIGIENKYYNAKQIKVDNPEEAIEEFLGIPPLEQDKGDWGFKGLKQAIKLEFRLGRYDDAITHYKELLTYVKSAVTRNYSEKSINNMLDYIEKSSDDVTAYHCMEEFYSLTLESFQNTNNERLWLKTNIKLAKLWLDKKEYAQLSRKLKELHKACQRSDGTDDPSKGTYSLEIYALEIQMYANTKNNKRLKALYQRALKVRSAVPHPKIMGIIRECGGKMHMSEENWKEAHSDFFESFRNYDEAGSMQRIQVLKYMVLATMLMKSDINPFDSQETKPYKDDPRVSGMTDLVDAFQRDDIHAYEAVLRNKPDLLEDHFIAENIGEVSRNMRTKAVMKLIQPYTRFTLAFVSKKLKISVAEVQDILSFLILDGELADAKINEEDGIVEITRRCDIDKERSNALLLWNNNLRMLYDSTFSQAEGFRPENVHNMHPLMGGFGGMRYANLYSHESAISGTNFGMGDRSFKYPKGKTGRSSWGKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAL6</accession>
    <name>D4DAL6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000212">
        <property type="protein sequence ID" value="EFE41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021725.1">
        <property type="nucleotide sequence ID" value="XM_003021679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAL6"/>
    <dbReference type="GeneID" id="9576808"/>
    <dbReference type="KEGG" id="tve:TRV_04164"/>
    <dbReference type="HOGENOM" id="CLU_049915_2_1_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="252"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="391" mass="42832" checksum="568D20FDEA7592DF" modified="2010-05-18" version="1">MDSKGETRDDMMLLGLSEPLALLVARRFAAAKNAGSLVFSQTEVTSLQSSTVPPLDEAALSILSLYADVDWQFQLRYCPALAVKPTNNSPLQPASTAASLPAKPKKVDPFENPHTDLLVAQIPASDPTHILVLNKFPVIPNHFILATKVFKPQTHLLEADDLHAAFACLKEWEKPTGELRGDENVQAAKQRKRLFAFFNSGEHSGASQPHRHLQFLPVEDMHQADDVANWQPLIDGGNHAEEKDNSEQLQQPKLPFVTYTAPLSPNPTPEELHRSYLSLYAMAVTAAAQHSESLLNGISASRALGTEGEAAISYNLAMTTSKMMICPRRSEHAWLPLEPEMKKGLVDEGLVKLNGTILAGTLMVKAEAEWNTLRQQPSMLENVLSSVGIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAX8</accession>
    <name>D4DAX8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021603.1">
        <property type="nucleotide sequence ID" value="XM_003021557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAX8"/>
    <dbReference type="GeneID" id="9578564"/>
    <dbReference type="KEGG" id="tve:TRV_04276"/>
    <dbReference type="HOGENOM" id="CLU_028621_0_0_1"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="489" mass="55121" checksum="9B27219501E621A6" modified="2010-05-18" version="1">MLDENLPSMQPSPSINPAFFVKPSSENPKSYSTLFVAQHGKEPQPAYTVRHLDPELQTSRNRYAVALYDAFCPDALYGEVLIVPKWTYPTFSQEAIRANGGVQPPPEPIMPTEFIIQLYNPEQQVLVRHKPKTWNTPATWAFEMPQKTFREPSKSQLDKTLTTPATSDATSRLRFNWRKDGRMGSKDLGCYLSGKVVGPSGNSKKNREPDITVAIFSALKEITLYEPNFSRVEMEDYKGLEIVLMLGAMVIRDVFFTPMKEAFNIVNPPSNPTSPVDKQSSTLVPPRPLNGSAGYPSASGPPSRSQPPAKPLPQQSQQPPPQPPRQNIPPADPRTQWELDAEANALKQQSEAEKRARLKREKEAEKKTKKLLEAEEKEARKRQAQVDKETERLRKIYGKEESKVLKLQQKQQANPRPPQPPRQTQNHPVPPHPRVQFAPPRPQSVAGGLRPPPQQQPSQLKEKRSIFSFRKKESGAPPNTLAKKRSSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB42</accession>
    <name>D4DB42_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021494.1">
        <property type="nucleotide sequence ID" value="XM_003021448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB42"/>
    <dbReference type="GeneID" id="9578475"/>
    <dbReference type="KEGG" id="tve:TRV_04341"/>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000035">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="428"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="780" mass="89131" checksum="985E6141CD7D7D03" modified="2010-05-18" version="1">MRRRVTEDSILAIQIFDQKKFKKKNQGFLGVINIRIGDVIDLAIGDDADIFALEMLTRDLKKSNDNLVVHGKLILNLSTNLSTPVPTSQTGASRPINNRTSTSPVPAAQTTTTSSVSTPLTGPRPTSTAQEPLVNNSSSHLVPTHPSSSASTAVAPLTTSPQQPTAPARPNVGSTFEDSQGRLPTGWERREDNLGRTYYVDHNTRTTTWNRPAQNYNEQTQRTQMEANMQMERRAHRSRMLPEDRTGANSPDSQQQARTPPTAPTANAVAMMASNTTTPGTGELPSGWEQRYTPEGRPYYVDHNTRTTTWVDPRQQQLVQMYGPDNGNHLASQTVNHLGALPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPGLRIMSGQCHVKVRRGAIFEDSFAEIMRQSPADLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVTLQDMEGVDEDFHRNLTWTLNNDIDGIIELTFSIDDEQFGERRTIDLIPDGRNIPVTNENKKQYVELVTEWKIQKRVEEQFNAFITGFNELIPAELVNVFDERELELLIGGIADIHIDDWKKHTDYRGYQEDDEVIQNFWKVIRSWDAEQKSRLLQFATGTSRIPVNGFKDLQGSDGPRRFTIEKSGDINALPKSHTWYVYFLFPYTSSTFFTNRNSFNRLDLPPYKTYEALQNKLTIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBX1</accession>
    <name>D4DBX1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cholestenol delta-isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04622</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000233">
        <property type="protein sequence ID" value="EFE40653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021271.1">
        <property type="nucleotide sequence ID" value="XM_003021225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBX1"/>
    <dbReference type="GeneID" id="9578116"/>
    <dbReference type="KEGG" id="tve:TRV_04622"/>
    <dbReference type="HOGENOM" id="CLU_731951_0_0_1"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="149"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="378" mass="43089" checksum="50A7DD14DEBD6EED" modified="2010-05-18" version="1">MQLAREAEEAAKNSWGLYPALMSKRIRNKAAMPGGAPGESKAKSIPAVALFRFSPFFCFFAASTSQPRHQFTFTGQRLTEKSERRETRDERAAMEPAHPYYPLDAKVVGYLANDWDVPTLVCAFLGGWGALLLLTLAVVSVARPSLKMGDKVAILWFVLKMRDLAANGRPGGSIHFFFEGYFVYNHTRMAPAQDFFGQLWKEYSLSDSRYLTSDPFVLCMETITAVCWGPLCFLLVYLITVDHPLRHSFQVIVSLGQIYGDILYYATSMFDHYFHQVSYCRPEGYYFWFYYFTMNAIWIVVPACKSTPTGLSSIHTDCDRLHVPEHRHHYQIDPVHEGRYHQPQNPVISPSSTQSYLMDSTTVLRAPCSTDIFSLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC54</accession>
    <name>D4DC54_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021189.1">
        <property type="nucleotide sequence ID" value="XM_003021143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC54"/>
    <dbReference type="GeneID" id="9578033"/>
    <dbReference type="KEGG" id="tve:TRV_04706"/>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="138"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="388"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="533"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="886" mass="98884" checksum="83B78082B4164130" modified="2010-05-18" version="1">MNSGNPKPRNDYFTTSRNPRRDYDYNYDYDYGASNNGSMNSPAGYGRGREGRGGGYGGGTYLESPSPGDSMEQLSPQISVRSRGRDIDDGPSWGGRKDEGRFRGSERQRREENARQRSASRSGRSGGSGREIKGGEEIDGVVQAIEDEWDFMADSECIPVQVGLQLMDTSTLGRADREPEFLQIHQRIQHALRSVVNEHHHGFNNLLGTYHNIQGSLQSSQHQIRTLKAALLEAKASLLTMKPELKEQAMASQSYDEILQLFELIEHAQSLPEKLEARMSDKKFIAAVDILKEGTALLQRPELAGIGSLGDLRTYFSNQETSLTDILVEELHDHLYLKSPYCCDRWKPSSDRDGASASASGTSWEKPFYQYLSSLDATTHFVEDISRNPETDTFYYIHLLLEALHKMGNLDVVVDRIEQRLPVELYSVVDKTGAEVNNSHPNFQKDTRKAGPGAVPDSASERRHLLSEFLWNLYAKFETIAEGHRLLYEVISGIVKRDKLANEVHLTSSFQELWKLYQSEVCTPYIKSAVIILMSTQMRSLLHDYLSTDGAESFRATTRATDNGYAHSSVKRDKTKKLFKMSEVDQAASDLKAEQDELAEILRASVPGLVPKSRQMFSTSDNNSSNQQNSGTGHKLLIEPSVFNISLLLPPALSFIHRLKEIVPPSSDIAVGALTSFLDEFLINVFQPQLDEAVSELCAINFISVDAYTEDPQWALHSPRPIFRGTINFMNLIKTFSRMLDSIPHDQAFTQLIIDQIITYYEKCCGWYKGKCVNSPIVSAIGSNEARTALMTRISPNHPGGVALKTSAAFAESQDIREVGRKLWECSASEKQSLINREIELLLSATNETSLKGYDMVADPKIVGSLSLLYNSMVNSSLGFAGCDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC63</accession>
    <name>D4DC63_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000237">
        <property type="protein sequence ID" value="EFE40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021167.1">
        <property type="nucleotide sequence ID" value="XM_003021121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC63"/>
    <dbReference type="GeneID" id="9578022"/>
    <dbReference type="KEGG" id="tve:TRV_04715"/>
    <dbReference type="HOGENOM" id="CLU_042557_2_0_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44882" checksum="24FE40F3420728F3" modified="2010-05-18" version="1" fragment="single">MTGPRYKFPNGQMVDKFLDVKNKSWEWEKKYGKTYRIWAATIPEKANILPGCWKSVITDPADVEVLYRQSTDHLKASQANAGWLLTQLLGSGLGLINGGRWTGLRKALDPTFSHQASMNLLRESLNVGAAEYVADIHKFAFPGKQGIDGDEFIINATESLQRYPFFEVASIFYGKMSKDEQERLWELGRRYSEVFASVVMGGIHRLKLTKYLNTATWKKTRQYQEAWHQFNNDMYKSREIKDPSCAIVTLMDAANKGELTQAEVYDTIAESTFANLDIVTHVISSCIILLADAANVQTELFAEIEKNKGDSEAYIPRKDTLLHYCLMESLRLRPVLTFTFPENPPREKTLGGFVIPKHTTIIVDAFAINIRNPFWAPDNRSYRPSRFATIKQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCA3</accession>
    <name>D4DCA3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021141.1">
        <property type="nucleotide sequence ID" value="XM_003021095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCA3"/>
    <dbReference type="GeneID" id="9577984"/>
    <dbReference type="KEGG" id="tve:TRV_04756"/>
    <dbReference type="HOGENOM" id="CLU_444078_0_0_1"/>
    <dbReference type="OrthoDB" id="4755622at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="62897" checksum="DDCBBFA07D391F7E" modified="2010-05-18" version="1">MFPTSGQGLATPERTSSSDTNPFRPQPPKINTNVPHITVNGKQVEVIEISSSPSPQDTIPASAQGIPAPGPPQGQPAQQPMHTQHGSPSSFAAAPAGSSQGPHTIFKPIKIHTAKCDVCNKHNKSTLQRCIDCGWQICTPCWNARGGNGAHGSVRKFTGTIYRSSDDELPQKKPRKKGKNVNNGAKDTPPDKGKAAAKDIASTSTRPNPDIEDNRNPSVVPIFSTVSANSSPGQLPMAAGDSRVVLQSGLGSFKIPSSSGPASVKPASSRNDLPRQATAGCSKAPRTPENIRQAIADNLSSSSSLTSLGALEEDCGYRGDEENENEDDDATDIDPENEDVLIADGRAYQKRVFKGLNPKAQTRMNWLLIAAEQALKEREKDQKQSRERNEGPKTPVPATRKFDPPARSWILTPSQHSSPAPKQDPAPEPSTVAVASQPPPSTPVPTQIRTIGATTVVRPVPISLYFRSPSPVPEHMRGIVQAPKRRILVQPLDLIEYVAPPAVPVSELIPRPDPMDIDQPRPGSNPSAARHPRMPLHQREVPFGLRDILPGDRETKKNETSERERHEAEKRILKAHGRAWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCB4</accession>
    <name>D4DCB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021152.1">
        <property type="nucleotide sequence ID" value="XM_003021106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCB4"/>
    <dbReference type="GeneID" id="9577995"/>
    <dbReference type="KEGG" id="tve:TRV_04767"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="49397" checksum="920522F283A284C7" modified="2010-05-18" version="1">MEISNHVAKLLVELSKSQDEEIGDGTTGVVVLAGALLEQAADLIDKGIHPIRIADGYDQACDIAVAHLDSISDKVEFSRNEQENLFKVAKTSLGSKIVSKAHDQFAKIAVDAVLSVADLERKDVDFELIKVDGKVGGSLEDSLLVKGVIVDKDFSHPQMPDEVKDAKIAILTCAFEPPKPKTKHKLDITSVEEFKKLQAYEKDKFTEMIKQLKDIGANLVICQWGFDDEANHLLLQNDLPAVRWVGGPEIELIAIATNGRIVPRFEDLSAEKLGTAGVVREMTFGTTREKMLVIEDCANTRAVTVFVRGSNKMIIDEAKRSLHDALCVVRNLVRDNRIVYGGGAAEIACSLAVEEAASKVYALDAIPLALAENSGWSPIETLASIKSKQVKEKNSRLGVDCMQTGSNDMRDHFVIDPLIGKREQLLLATQLCRLVLKVNNVIIAGEDNDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCH0</accession>
    <name>D4DCH0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-mandelate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021073.1">
        <property type="nucleotide sequence ID" value="XM_003021027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCH0"/>
    <dbReference type="GeneID" id="9576720"/>
    <dbReference type="KEGG" id="tve:TRV_04824"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="45"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="125"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="315" mass="34905" checksum="2B56DC57B80791F7" modified="2010-05-18" version="1">MAQQKPKVLCLSYPEFTDKAYLADFQTKFELHSLTSPARAGLVPELAARVREDGPFDAVIVRIGTIVFEPFDAEMLSPLLPDCRIIASASAGYNEFDVDWMTRNGIWFCNSRNAVSECTADMAIFLILAVLKNASVAERCAKSGVWRQGIEGVSRSPRGMVLGIIGMGSIGKYLAKRADVLGMKVVYYNRNRLAEDVEKQYNARYCSTLDELLACSDVISVNCPLSKETTNLLGREQFEKMKNGVYFVNTARGQIVDEEALVDALKSGKVKMAGLDVFPNEPNIKLSELECFENIKAWYATGVPISPVNEIEKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCH6</accession>
    <name>D4DCH6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021055.1">
        <property type="nucleotide sequence ID" value="XM_003021009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCH6"/>
    <dbReference type="GeneID" id="9576703"/>
    <dbReference type="KEGG" id="tve:TRV_04831"/>
    <dbReference type="HOGENOM" id="CLU_588193_0_0_1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000013">
        <property type="entry name" value="Similar to TBC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="30"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="465" mass="51286" checksum="47299E0DD72E8A41" modified="2010-05-18" version="1">MLQRIWDDYVFPDWDRVIAEPRTRELWWRGITPRSRGAVWQRAIGNELALTEESFVKALERAEQLRSKTGDGYKWAHERFAAIRKDAASAFPALNVFAEGGPLHDSLVQVLDAYAMYRSDVGYIHGIHTIAAVLLLQLHTASAAFLTLANALNRPVALAFLTSDPGATARAYSLASATLRLKFPRLSTHLCENLCLSDSQIWEPMFRSLFTNGLDVDHVSRIWDCWVFEGDRILFRAGVAVLGCLETQLLGLVPGEEGQRGATDVLGWGSKRLSRRGRSRLSGRQEGDLSSPLLLFFSSSSSSTTSSSFVLSSCTSASLILICNNQCLINLSSINVCLLYLISDITPLSVHPGIVAEKQRSGRVALAAFEASSIKVEGRRAVQQLSAPPAIQRHFPGCDRRVLLLLLACLLLFLPVCLCLVVLFVSSGELGDGETDGEQMAYMSTWSISRREKSSKSRYPFGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCP9</accession>
    <name>D4DCP9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021039.1">
        <property type="nucleotide sequence ID" value="XM_003020993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCP9"/>
    <dbReference type="GeneID" id="9576686"/>
    <dbReference type="KEGG" id="tve:TRV_04904"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="33688" checksum="C52BB7E6A72B840B" modified="2010-05-18" version="1">MHNQEFNYQTNLYPTIRKLARLRAQLLEPTGGSGSGGGAGFDVSKSGDARISLVGFPSVGKSTFLSKITKTKSEVAAYSFTTLTAIPGVLEYGGSEIQILDLPGIIEGAAEGRGRGRQVISAAKTSDLILMVLDATKKAEQRALLEAELEAVGIRLNREVPNIYLKVKKAGGMKITFQSPPKYLDEKMLYNILRDYKVLNCEVLNLFDSSNRPIPSLYVYNKIDSVSLDFLDQLAREPHTCVMSCELDLGIKDVVDRCWQELQLIRIYTKRQATPWSHLFVLNVIVIANRSVEKEWTPTSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDS6</accession>
    <name>D4DDS6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020611.1">
        <property type="nucleotide sequence ID" value="XM_003020565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDS6"/>
    <dbReference type="GeneID" id="9577310"/>
    <dbReference type="KEGG" id="tve:TRV_05288"/>
    <dbReference type="HOGENOM" id="CLU_042426_1_0_1"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="218" mass="23738" checksum="E5B7627EDBD5DC99" modified="2010-05-18" version="1">MAPTAKPTLAPLKTSKSPTFPSELHDSPLFSGKTESIKQEDFLRTPITPPTAYTDFLKTVTPIVASPSSSKDKSFDRLAVSISHPSTATSPYFCNCSNSCRKSPTVASITSSPVALHHHYRSSDGVRKTPTSAKPLRISAPSPKLTSPSFDSPRCCSARSPLPPPDWITESTTRQTETPRCSSCSRPISVRHVITRTITYKRTALEPAPKGKRRKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDV6</accession>
    <name>D4DDV6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000274">
        <property type="protein sequence ID" value="EFE39966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020584.1">
        <property type="nucleotide sequence ID" value="XM_003020538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDV6"/>
    <dbReference type="GeneID" id="9577284"/>
    <dbReference type="KEGG" id="tve:TRV_05320"/>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="16584" checksum="7496740C5D75FD0D" modified="2010-05-18" version="1">MSDWDSVTIIGKAARGGSAPRETVVKGRSALNAAARSGMIVGTEKKYATGNSASRPAVEGQHLTKVDRSDEIVKPKTVGHEVGDAIKRRRNEEGIKLSQKELATKCNTTVSVIQDFERGTAAPDQKVLAAMERVLNVKLRGSGIGQEKFPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE64</accession>
    <name>D4DE64_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020464.1">
        <property type="nucleotide sequence ID" value="XM_003020418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584203"/>
    <dbReference type="KEGG" id="tve:TRV_05430"/>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000212">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="86"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1244"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1371" mass="154601" checksum="B58A13ED62E0AD8A" modified="2010-05-18" version="1">MVVSRPREREQQDNGDASATRTSNTPTRRMSRADSSPPKKDRERERDRDRDRDRQIKSSAKDVAELTDFVCLLYLAVSEGERERKREEGRELTDSEWMEWLIALNWGTGETVAVKQIRLADLPKSELRVIMHPNIVKYHGFVKSAETLNIILEYCENGSLHSISKNFGRFPENLVGLYMSQVLHGLLYLHEQGVIHRDIKGANILTTKQGLVKLADFGVASRTTGLHESSVVGTPYWMAPEVIELSGATTASDIWSLGSTVIELLEGKPPYYKFQPMQALFRIVNDDHPPLPQGASPAVRDFLMQCFQKDPNLRVSARKLLKHPWIVNVRRCDSVVPKKSTEYEEAVRSVQEWNEALRSPNSNAIRKPSQHPQPGIGSSPISTQKELNPLTIPNRDTSSLLNMNAAEKYRSPENTNDDNWDDDFASAISPGALHLPHLKPQDNFDGMLSPEKLKAFASLEGITELCQTDNPGIDNDGQINDAMNNDEPDPLQTIRPRSRRSFDDEVMPPRSPRRRHRQYPVSAFRRGPIISSTSGAAKPIRQRPANFYEESSVEDYSDLIEANDEVLESKLSAMPGIGQDESAAHTQPVMGQEIFSGDENTPVKPSVRRRKRSEFARSRSAIEIEMYAEDEADEDFSDILGDNENTLVKLESEEGSDRSALMLNSKLSTNSWLGDIDDEDDPFAQLEEGLDELDLEANIARDKYARLRNQVEGLVSSLKTSQDDEVLVDISEQLMTIFSDMPETKSVIMSAHGMLPILEILDTCRRRDVISNLLKIVNAIIYNDYEIQENLCFVGGIPIINKFASKKYPREIRLEAAAFVQQMYQTSTLTLQMFVSAGGLNVLVEFLEDDYEDERELVLIGVNGIWSVFELQGSTPKNDFCRILSRNSVLDPLSLVLSRVLDEEEGEMAEVCEARISNIFFIFSQAESHVKEMVAERTVLHRVLKELKRMSPSPQITMLKFIKNLSMLSTTLDSLQNSNAIDVLTELLRSTMKKPHFREVSNQILNTIYNMCRLSKSRQEDAALNGIIPLLQKIVKTERPLKEFALPILCDMAHSGKVGRRELWRNKGLTFYISLLSDPYWQVTTLDAIFTWLQEETAKVEEYLLDTQHGDSSFTIAIIRCMTISKANAFENLLEPLQKLLRLSPAIAATFARPDMFERIGQKLQHTKPSVRVNLLRILSTICDSSQEQCGLLRRYGLLDAIRELQKDSRVLVRELAGQLVKNSEDSDNASLNGSKRRQRRRSTSTAAPPSLISSHSMPASPQVTRPISQKPYYEGRESSRRQNGLDSSLNLRPGSRDGGRPPNIHPGLSGNGSTGLPGKTPRLNHRLSQQLLPGSPQKEEIRTPTTTRTPSLLQPSSRRRRQTNTSSNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE89</accession>
    <name>D4DE89_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000287">
        <property type="protein sequence ID" value="EFE39837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020455.1">
        <property type="nucleotide sequence ID" value="XM_003020409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE89"/>
    <dbReference type="GeneID" id="9584194"/>
    <dbReference type="KEGG" id="tve:TRV_05456"/>
    <dbReference type="HOGENOM" id="CLU_102602_4_4_1"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="84" mass="9383" checksum="4B2B0E3CE6F3D538" modified="2010-05-18" version="1">MTKTFTVAEVAKHKTPESGLYIIVDSSVYDITNFIEEHPGGSRILKRVAGKDASKQFWKYHGDGVLKKYGAKLKIGEVKEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC9</accession>
    <name>D4DEC9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-classical export protein Nce102, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020378.1">
        <property type="nucleotide sequence ID" value="XM_003020332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC9"/>
    <dbReference type="GeneID" id="9584137"/>
    <dbReference type="KEGG" id="tve:TRV_05496"/>
    <dbReference type="HOGENOM" id="CLU_098356_0_0_1"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="178" mass="19570" checksum="F76CEE0A2C2AE956" modified="2010-05-18" version="1">MPDVAKWGSAALRFIQLALAVIVMALIGNMIDDAIHGSSSVVNYNLFVPAFILLSLLYLIPASLSDKIMLHPILMFFIDALCCIFAFCGAIALPARQHVHSCSNKDYTSTNTVSSGSKSGEKTCREGQAATAFLWFLWFAFLLSTLYSLWRVKQRFSGGGDRQRTSPNRGQPPTMSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET1</accession>
    <name>D4DET1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000310">
        <property type="protein sequence ID" value="EFE39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020259.1">
        <property type="nucleotide sequence ID" value="XM_003020213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET1"/>
    <dbReference type="GeneID" id="9582800"/>
    <dbReference type="KEGG" id="tve:TRV_05671"/>
    <dbReference type="HOGENOM" id="CLU_001265_17_1_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055480" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22907" checksum="6191D2217B8A1204" modified="2010-05-18" version="1">MSSSLACSICFIAITISLSLSENGHGDKYKLGIVAVSFFFAFFASFGMGVLGVPWLYPTEINALEMRTKGASLAMATNWIMITLPGIENLGWRFWIIWAVICFSFIPITYLFYPETANRTLEDIDRYFEANRGIIVAFNKSKAFPVLIKYLYANSIPLAATQLSRPDEYIRMDEEISQRDTVEKSSASTSMRNRQSEEKISQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET8</accession>
    <name>D4DET8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020239.1">
        <property type="nucleotide sequence ID" value="XM_003020193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET8"/>
    <dbReference type="GeneID" id="9582780"/>
    <dbReference type="KEGG" id="tve:TRV_05678"/>
    <dbReference type="HOGENOM" id="CLU_026445_0_0_1"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="564" mass="62270" checksum="53F8CFFC71AA4BCD" modified="2010-05-18" version="1">MGFFRRKEGRAASNNNNIHNIHNIHHHFEKDGQESVFSNSSSRASSTSARLPVSSIRSSNNSPTSHPIPEAPMAPPPDPNLDPAAYLRSIHAVRQRCGLVMEKAKENQLNHFDVDMSKFQTTAQYIVSIIKRDYAPDFQSIPDHGRWQHFDVGGKPRINQLLQSWPSTIDNLERARRLIDLFLVSVLLDAGAGNTWSYKSKESGKVYRRSEGLAVASLEMFKAGMFSSDHTEPCQVDGAGLRRLTVGALAKRMQHSEENPLAGLEGRAGLLARLADALNNQELFGVDARPGNMLGRCFAFDLSSPTTHCYSANPLLDYLLSHPSTLASSVPIIPVPLLWNVLMDGLSPIWPPSRTQIDGISIGDAWPCKAMPSSPPAEPWENIVPFHKLTQWLCYSIMAPMTKILNIRFSGRELLTGLPEYRNGGLLIDMGLLTLKPEDTNRGLEAYKANAMIKGQPNVEVVPLFSPDDDVIVEWRALTVGFLDQLLAEVNNLLELKDGQQLSLAQMLEAGSWKVSCLSILPCFPLIALTSTDINLQGGREIAEVSRPNTKQPPIMIISDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN2</accession>
    <name>D4DFN2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020014.1">
        <property type="nucleotide sequence ID" value="XM_003019968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN2"/>
    <dbReference type="GeneID" id="9580183"/>
    <dbReference type="KEGG" id="tve:TRV_05983"/>
    <dbReference type="HOGENOM" id="CLU_1448713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20252" checksum="58CAC1A3AF82CA10" modified="2010-05-18" version="1">MGLGAKGTTTPSSSSSQVLDSGTAASQHLENYSPSQLPGEEPVYSSQEYPIKCILDESGGKYLIAWEGSFEPTWEPKSCASYAAVRAWEVEKQKRYISAKQYKEQRPRRTCQTPRRKPLDLVSSSSPGIFTQQSIEASQPSSTNPNSSNPSFSQATASSGSIFCPETQSQSTQASRESSGRSGIQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFW5</accession>
    <name>D4DFW5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019870.1">
        <property type="nucleotide sequence ID" value="XM_003019824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFW5"/>
    <dbReference type="GeneID" id="9584621"/>
    <dbReference type="KEGG" id="tve:TRV_06068"/>
    <dbReference type="HOGENOM" id="CLU_000604_6_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="158"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="470"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="725" mass="80894" checksum="A8EE65C79BE39214" modified="2010-05-18" version="1">MFLVAGLLPDPDEPFSPSLSHAHAWILAAVTEALQIAMFCFQFGKDPINSGMESVQLGLLMLRMGFFVAMAAIYLQPMYAWSHIKLGETDPLLGEIAAKPVRDAQHGGWLDYVVGFSTLFPYLWSVIPNPPNISHFPHHANGNIYRPSDSRRLQLRAVFCFFLLILQRIVNIMVPRQLGFVVASLGSGTIPYKQLAIYLVLRGLQGQQGVIGSIRALLWISVSQSTYRRLTSSAFEHVLSLSLEFHLGKRIGEVMSALSKGSALNTFLDGLIFQLFPMVADLWIAALYFLIEFGAFYALIVISVTWLYLFVTIYMAKYRGRARREMVNREREMEAANRFNGLIKSFQGAEYFVFFSLNMLNATQNLLFTAGVAIVCLLCAYQISADMQKVSMFVTLITYLAQLQAPLNFFGSFYTQVQNNLIDAERMLALVSLVMTAETVLMLTAIQFKEKPLIQDGDNAMPLNYCKGKVEFKNINFAYDGRRPALRDVSFVVEPGTSTAIVGESGSGKSTILKLLFRFYDVAGGSVQVDGMDVRDMTIASLRSHLGVVPQDAILFNDTVLYNLLYARPEATMEQVYEACRAASIHDRIMSFPDGYETKVGERGLRLSGGEKQRITIARTFLRSPQILLLDEATASLDSQTERQIQGALEKIAKGRTSITIAHRLSTITKADQIIVLHQGRVVEKGTHTELLSANGMYSQMWEKQTKAKVKADNENDGNLLISPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ5</accession>
    <name>D4DFZ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019809.1">
        <property type="nucleotide sequence ID" value="XM_003019763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFZ5"/>
    <dbReference type="GeneID" id="9584560"/>
    <dbReference type="KEGG" id="tve:TRV_06097"/>
    <dbReference type="HOGENOM" id="CLU_062645_0_0_1"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31086" checksum="B365A1F59D364175" modified="2010-05-18" version="1">MERIKRMAQEELRNFLALAKDGLRSGAYIYPFQGIAYFLSHPSLYKPMLSKLAPTLSLTLAVTGAMFFFTYIPQAAILALTSGPLIAPFSAALLVLSESSTIISYLAKSGYVFDQDTLLNLFDGTLLSCGNTQLVSKDRKLKSASDPMARLGHFIKKGGGSLMNAMSLSNMFRSLLYLPLNFIPVVGTLMYIGAQGTRIGPMLHARYFYLKGWGAMEHDQWLERNRGAYASFGAAAFVLEMVPFASLFFTYTNTVGAALWAARLEKTFATNPGLRGATEMKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG19</accession>
    <name>D4DG19_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019833.1">
        <property type="nucleotide sequence ID" value="XM_003019787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG19"/>
    <dbReference type="GeneID" id="9584584"/>
    <dbReference type="KEGG" id="tve:TRV_06121"/>
    <dbReference type="HOGENOM" id="CLU_019189_13_0_1"/>
    <dbReference type="OrthoDB" id="4206040at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="565" mass="64946" checksum="4D065F46BAA6B01D" modified="2010-05-18" version="1">MFSRNPGHRNRFSRFFTKAIWKMATQKDWNSTESFYNYTRGRFVVNEAEEMRQRHVRFDVNELARLAANTVGAKEVVNIEKCADGLFNKAFVFTFEDGKQVVGKVPNPIAIIPHLTTASEVATMEFMRTVLKTPTPRVYAWSSRVDDSKNSVGAEFIIMEKISGIPLGKVWERLSGSDKMKVLINIFKYQNEWASVAFSRFGSLYYSGDVDILPADYLYIDKNGNQVNNPRFVVGPASHNEWFIHGRDSVSCDRGPWNTVIDYRKAIAHREITASRLLPFPRQTLLIYGPRPLYLPTVEKKVAALKCSLQSLETFLPEDPALLRGHLWHTDFHHENIYVNPGKPTEITEIIDWQSTPITPLFDQPLDLPFVNYDGPDIGENLEIPVLPDDFQSMQEDEKKKVHKNYMDKSAVVAWRLLLKHKNPAYYRAVLFKHTPIGLTLELSRQVFTIGESSLRTIYAEMGEDWQEYAPKGSDMNPVPCPFNFSQAEITEIDEDEEATASSTRIAAQIQEHLGPLYPHKGVIEHENYEEVKKILGEIKQEVIEHLFESTEDIQTFDSQWPYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG58</accession>
    <name>D4DG58_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial outer membrane protein (Sam35), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019783.1">
        <property type="nucleotide sequence ID" value="XM_003019737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG58"/>
    <dbReference type="GeneID" id="9583706"/>
    <dbReference type="KEGG" id="tve:TRV_06160"/>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="181"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="396" mass="44165" checksum="6681B93B3A3AB57E" modified="2010-05-18" version="1">MERKKKKKGDVKKKRTKTAARDAGTDDEEDDDGNDGDDDEDEDDEEDKHELMPAKTDSAMKTAEEGPKSWLPAIPKPVKRLFDQFPLVTYPPNTAPASSSSTAGPASSTGTDTNVGANERPGEHRLYIFTSADAARNGRPSVNPQCLMWQVSNPSSSGARSLLSVAFDRLPDLHFADKVEQAYLRFRGIEFRTVPSNNHASPDGALPFLLPAGPGGDSEPSCVAPSKLQNWADTNAKHQYTEAKISGVLRTYKSLLERNIRDAWLYTVYLDSSNFESIAKKAYVNPSTTNPLVRATLAYQLKEAAKDQLQRKETYIDPDDILAEAKQAFKSLSSLLGDNDYFTYDSTPCWFDAAVFSYTHLILDKTLGWKFNPLASYLEEHPNLVQHRQRLLDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGK0</accession>
    <name>D4DGK0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019675.1">
        <property type="nucleotide sequence ID" value="XM_003019629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGK0"/>
    <dbReference type="GeneID" id="9583563"/>
    <dbReference type="KEGG" id="tve:TRV_06304"/>
    <dbReference type="HOGENOM" id="CLU_1490053_0_0_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="181" mass="19645" checksum="0C5A1070D4FF8138" modified="2010-05-18" version="1">MSGHVDLQLFTGGDRFTTVTPDDHGGILWVASIICAIYVVLSMGLRAYVKREFYGLDDLIALFATLIAEAQYISIFFGLSDGLGKNDESFGMVHIRRIGRSLALSEVFFLLGLLLAKVSLILLIRRLFSPDMRSHIMTCDAVLLLSILWGVGSMLGALINCSPTGMMAFIHGACKGIVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGV0</accession>
    <name>D4DGV0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019531.1">
        <property type="nucleotide sequence ID" value="XM_003019485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGV0"/>
    <dbReference type="GeneID" id="9578305"/>
    <dbReference type="KEGG" id="tve:TRV_06405"/>
    <dbReference type="HOGENOM" id="CLU_1004614_0_0_1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="34029" checksum="0490C283D4184654" modified="2010-05-18" version="1">MAPRNYSELGRSLGLLGDQLPWYWKVVSVGSAWSLLTGYVMCFLFVLISAAAVEVEVEVEVDFILFPFAMEPNGAELGANKNALLGTAVILLTLAYLLSALYYVRWRRSIYLFNSLFFACFTSSILGMFNVVINILVRKLLPMSMLSTIIVAISCVSTAAYGLLAFYFSDYWLTVTCSRQRRRARTRAASEVAPDDAELQRRQLLRLYLRPDRAPSVELSQSTFRIDLPDPQSIAGTEEEMLVTPPQNAYERSLHSVSAPSNYPFEVHSSPTSAYKLNPLRYWQPQRSHRDQMRPLAELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH16</accession>
    <name>D4DH16_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000368">
        <property type="protein sequence ID" value="EFE38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019492.1">
        <property type="nucleotide sequence ID" value="XM_003019446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH16"/>
    <dbReference type="GeneID" id="9577941"/>
    <dbReference type="KEGG" id="tve:TRV_06471"/>
    <dbReference type="HOGENOM" id="CLU_015166_15_0_1"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13941" checksum="0F4DBF760DDF5EDD" modified="2010-05-18" version="1">MTIPFTAAQFMAYESTSKIMNPTKRYDPFTHCIAGGLAGAVAAAVTTPLDVIKTVLQTRGTAQDPEARTAKGLFNAAKLIKNQYGWAGFLRGMRPRIIATMPSTAICWTSYEMAKAYFKRITSEESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH64</accession>
    <name>D4DH64_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019439.1">
        <property type="nucleotide sequence ID" value="XM_003019393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH64"/>
    <dbReference type="GeneID" id="9577889"/>
    <dbReference type="KEGG" id="tve:TRV_06519"/>
    <dbReference type="HOGENOM" id="CLU_025005_3_1_1"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="516" mass="59546" checksum="54809C24E5814127" modified="2010-05-18" version="1">MARKRRLMRREITFSSASKKETDILHALSFYPQSVTFFTRLQTNLSLIQQAAAYHLRLSPEACFVPSDFNDWHWGSFNVCIPIIVAGSRRALIRFPLPHRVGELFRRGNADEKIRCEAGTYAWLQENCPSVPIPKLHGFALSTGQTFTAIENLPIIRRYIEHIRRFALGLLAYPLPSTYVPRGRTGTQSLAYAVGAGYILIDYIEEAEGTMLSRTWEDRRSDARLRSNLYRGLSRILLDIARIPLPRIGSFIIDDHGYIQLSNRPFTLEVADMENCNIPLNMPREVTFSSADSYLASAISLHDNRLRHQPNGAIDRQDCIDQMSALTMFRVVAPRLFRPELSHGPFVYMLNDLHRSNILVDKDWNIKYVIDLEWACAKPIEMLHPPEWLTSQAVDEINDDAYNTQRLEFMSVLQEEEQRMCGGSDSISKTMHQGWSNGTFWYSLALQSPTGIFSIFYDRIQPQFERSHATDPNFYRISYPYFTTDAHAFIAHKLQQRADYDRQLRTEFDMPQLPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHF7</accession>
    <name>D4DHF7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019332.1">
        <property type="nucleotide sequence ID" value="XM_003019286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHF7"/>
    <dbReference type="GeneID" id="9577654"/>
    <dbReference type="KEGG" id="tve:TRV_06613"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44574" checksum="5A818ED7E9C05670" modified="2010-05-18" version="1">MPLPILAEGATRGLSAIPYGYTAMKTAAGLAVIAALKRYFGGATNKSDRVMHSKVVLVTGGTSGIGAAVVRELAIRGAQVIILTQHLPSDPFIVDYIEDLRTLTGNELIYAEQVDLSSLYSIRLFATKWIDNSPVRRLDMVVLCANTQKPSSSRTSHGTSEGLQEEWQINYLANYHLLSILSPALRAQPPDRDVRVIFTTCSSYIGANKLDLKVLEKATVIQHSVDSSTKQKAKKGPESLVSSSSITPGTRRWLTGGSLWGLLFYLITWPIWWLVLKSSEQGAQSILMAAMEANFSGVGNTAAVSLDEIKKMAGENSDMTGRMKVGIEGGTLLKECKERHVLRSEIMDEKAGKELWEFSQRQIEQKEKEAALLRAMEKKAREEEEEEKKKQPKTETSTEGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHQ2</accession>
    <name>D4DHQ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000383">
        <property type="protein sequence ID" value="EFE38620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019265.1">
        <property type="nucleotide sequence ID" value="XM_003019219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHQ2"/>
    <dbReference type="GeneID" id="9577504"/>
    <dbReference type="KEGG" id="tve:TRV_06709"/>
    <dbReference type="HOGENOM" id="CLU_110291_1_1_1"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14234" checksum="AC6881AD3CDB40F4" modified="2010-05-18" version="1">MQGRRESSLNASVHKLYNSIQLLTNWPPPQPKADAFNCAQRAHTNYLENAPQTMLLTLVAGLKYPAATTLIGATWVVMRVLFLYGYVYSGQAAGAGRKYGGGFWFAQMALWGMTVFGVALPMMQAPASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV9</accession>
    <name>D4DHV9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fusion protein (Ugo1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019217.1">
        <property type="nucleotide sequence ID" value="XM_003019171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV9"/>
    <dbReference type="GeneID" id="9577214"/>
    <dbReference type="KEGG" id="tve:TRV_06766"/>
    <dbReference type="HOGENOM" id="CLU_029376_1_0_1"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58665" checksum="3E6E589E480575A1" modified="2010-05-18" version="1">MNSTPEGPNPLRPYYVPPPIGLSGSHAASKVVSSAAAENITSFGTSARDILSDFDYSDYLGDSSPSVTESIKQLFENAARRYSRVLMSQPFEVAKTILQVYVAEDAAAEVAEERRKLDRQQMEQDEENVFGSDDENNYFTSAAPNASTYATSSSRVRAKAPQRVTDRAGYIPQSAQPKYMLKVRDSSSMLDVLSQLWTTSGPTSIWKASNTTFIYSILLPTLNTFVRSLLSAILGYPEDSFSSFPASDILTSTSPGTDLILSCLSSALSAIILSPIDTARTYLILTPHGHGPRSLLHSIRLLPSPSYMISPHLLPITILTSTLPNLISTSAPLFLKSYLSLDPTLNPSTWSLFSLMAQGLELTVRVPLETVLRRAQMATFTSSALRRPGVTYSTPSIPSPTSSGPSTTLAESSSNLNTPLPTIVPSPQSYRGIIGTMWNIIYEEGTNPTPTDLDTIEQVLGRPPQVGRQGSRQIQKRRKGQGIQGLYRSWRLEMWGIVGLWGSSFLGTLLSGEEDDIAPDSMGKMSLGSTGGHVGTEKGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI07</accession>
    <name>D4DI07_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019130.1">
        <property type="nucleotide sequence ID" value="XM_003019084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI07"/>
    <dbReference type="GeneID" id="9577158"/>
    <dbReference type="KEGG" id="tve:TRV_06814"/>
    <dbReference type="HOGENOM" id="CLU_022670_4_2_1"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="40535" checksum="9A0FFBCF1AC23ED7" modified="2010-05-18" version="1" fragment="single">IDITTPYAIQAIMSTTEQRESGPGPAEETLAENFSRVSVNDQPEAEAPPKTEEEYAQSMLTLRAIVSSKEAGVIIGKAGKNVADLRDETGVKAGVSKVVQGVHDRVLTVTGPLQGTSKAYSIVAKSLLEGAPQMGMGGVVQNNGTHSVRLLISHNQMGTIIGRQGLKIKYIQDASGVRMVAQKEMLPQSTERIVEVQGTPEGIEKAIWEIGKCLIDDWQRGTGTVLYNPAVRASVGSGSGQGAVTGTNSSYGGSSRSYNRTGNGADFSDHPSSYSRRGNNDNPNRGIPLVTEDGEEVQTQNISIPSDMVGCIIGRGGTKISEIRRSSGARISIAKAPHDDTGERMFTIMGSAQANEKALYLLYENLEAEKMRRSQQQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI70</accession>
    <name>D4DI70_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019099.1">
        <property type="nucleotide sequence ID" value="XM_003019053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI70"/>
    <dbReference type="GeneID" id="9582585"/>
    <dbReference type="KEGG" id="tve:TRV_06878"/>
    <dbReference type="HOGENOM" id="CLU_021115_0_0_1"/>
    <dbReference type="OrthoDB" id="4198732at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="315"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="729" mass="80329" checksum="48A91113731B3381" modified="2010-05-18" version="1">MAYDGYRASFDPPGFNPNASTSNSYTSSSSNINNINTNNGGGSTSSSANISSTKPSNAPYPGYLQPSYGEYPVEQDPSSHPPPPPPPPPSATPAAAAAATTASAIPCGISSTRPGSRAADAVKQPFSRTSSQPEPPTPRVPDPNYPSTDLIAQVTAAVIQQLRAPGPGNAPPPPSHPSQQQAQQQTVYQPPTPALSQSSYNRQSPNPNSLSPPIATSPYGPPQPSIPGQPDLSNAPAQSSYPPISSRVDGSAYNGPQVQNPADNGQQQTTSPGIDRARGSSIGSFNGGRNGTNPSKGPSRHSTVTNEAISEKPWGTLFDKDDMPTSRAGQLLRGIALHMIETYPPGNTLVITPEKLQKFYRDHRVSSDSYPWQDIFDNRTSSISRLFRSLSIEHHLVQDQLDERPDIPGLTPRGFERWMSMMIQAHPEREFERVKNIVQNIPITNPDDRTERFPKELRRKLFPQLPDYDIKETLDRWITTHCHVELTQGMLGGPPMRQPRAKSTVDNTSTGIPSRPASTDVRPRQFPPAATVEDAIDEDDHVIVASADVADVDAAAQPVQPIERERKPYSMPGGTKGYREDTSPHPTTSTSRHPDSNSGVSFGKKHVVVYSGDDDDDFSSPRDDVNSKYSSSHHGNTHPQSHAHTHPHQHSHPHTHDDSKRHHGRDKDRDRDRDRDRDLDWDGDKSRRRTSWGSDEDFYRNPVSDRDRGRKRTESRTRFSDYDKFWEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH5</accession>
    <name>D4DIH5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018972.1">
        <property type="nucleotide sequence ID" value="XM_003018926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIH5"/>
    <dbReference type="GeneID" id="9582133"/>
    <dbReference type="KEGG" id="tve:TRV_06984"/>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60999" checksum="A441D74E5D643C42" modified="2010-05-18" version="1">MPEVRQALPLLRVHLSRWFSGRKPAENECAVNYLLLVAATRKRKKTTSSHSFNQRTTSWLDDFYTPYDLIYGFVVGFPENSSYLRQASGLLVFFFFFFCNQLCPGTSWASWTLLVSHRRQAAKLHREGGIRSETTRGLQGRKGQKRKEKRESSRASSCLWLLLAPDDEAYRMRFKSQLTNVATFSKFTASLSSLGKVCWVRLEDEVVRFSIIPDQGTQVWAQLPIHTVFDSYSFSSVAKVINLEVPIGALHRALKSATGATSAQLRLTKKGNQPQLALTVVTSSWTSGKGASNSDEPARASGSRPANPQSLENGGALSGIPAAELLQDGPRERETIVTQEIPIRVLHPSAVEGVHEPRCRDPDVHIILPSLIQLKSISERFTKLATDAASSKAGNVSAGGNGNGPALAGGSHSSGPKLELSANMHGSLKLAIATDALRISSVWAGLVNPPLDQADMTQSEIAQLPSERMRARAADGEEGWAKVRIDGKDWGRVLSVGRLSPKVVACKYFYSSFILVVPSSSADPVGFIHETALVLYVYLPGGIGGEDSCLTYYINSYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIM8</accession>
    <name>D4DIM8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019025.1">
        <property type="nucleotide sequence ID" value="XM_003018979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIM8"/>
    <dbReference type="GeneID" id="9582430"/>
    <dbReference type="KEGG" id="tve:TRV_07038"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="551" mass="64230" checksum="741BEFDDDE6F05CF" modified="2010-05-18" version="1">MTKKSSSRWKSHFNPSKLFFYFIFYGIQIGFFAYGWWKQVTDQRLATLNTLTFSVWMSRGAGFVLSIDTALILFPMCRTLLRYVRPKVKWLPLDEAQWFHRQIAYSLLIFSVIHVVAHYVNFFNIERYQTRPEAAVQIHYTQAAGITGHVMLLCMLLMYTTSHHRIRQQSYETFWYTHHLFIPFLLALYTHATGCFVRDTPDPISPFAGKRFWDHCIGYEGWRWELWGGGLYLIERLYREIRAARDTEIVKVVRHPYDAMEIQFRKPSLRYKPGQWLFLQVPDVSRTQWHPFTITSCPHDPYISIHIRQVGDFTRELGNRLGCGPEQAKDIDGLDPLGMYEIAMQNGQTMPQIRIDGPYGAPAEDVFSNDVAILIGTGIGVTPWASILKDIWHYRAGPNPPTRLRRVEFIWICKDTSSFEWFQALLSSLEAQSAEEARSGQEFLRIHTYLTQRFDQDTAANIYLNSVGQELDPLTELRTGTKFGRPDFARFFRALRASIMDRTYMSNLEATRRADVGVYFCGPNQAAKQVKKAAKECTSKEVKFKFWKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIT4</accession>
    <name>D4DIT4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI transamidase component (GAA1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018869.1">
        <property type="nucleotide sequence ID" value="XM_003018823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIT4"/>
    <dbReference type="GeneID" id="9581513"/>
    <dbReference type="KEGG" id="tve:TRV_07095"/>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70407" checksum="03EEB8EDECCB8E29" modified="2010-05-18" version="1">MTTIATLVAKLRHDPRPLYKLPPYISVLLILVGAVWLLLLPLNEYSRETYISENALLPGQVHTYFAGSEQNIFRAYRQELDTVKDRDYSFISEKLQSVFRESGLKVATQNYEYQSSGNVYTGQNVYSVIHAPRGDGTEAMVLIAAWKTVDGELNLHGVALALTLARYFKRWSLWSKDIIFLITPDSKSGAQAWVDAYHDMHPPSVQPLPLKSGAIQGAIAFEHPQNHRFESLHILYDGVNGQLPNLDLFNTAIAVARGQMGIPVDLQHVWNHDNKYQKRLQTMLKGMIRQGLGHAAGVHSSFIPYHIDAITFQTIGSGWEDEMALGRSIEGVVRSINNLLEHFHQSFFFYLLMHTKRFVSIGTYLPSAMLIAGNFTIMAIGLWLKSGRRTPNAPLETHLTPLDSKSGEEKLNATTIAIDGVNRAVERHMSLPLALVLGLHFLGAVPLYTFNSLPHNLLSYAAYIFAVANIAIPLVISVVVVYFLRPTTQQFILTKSFSLVLLGLFLSALATLNFSLSLLLGLVCTPLTFIGYMESSATQMGRSKVQPQTEAERDARALLLVKTAFGILLLNLLSPTALLLGICTVYNIPVELVLSEAAFGWNVWGMWTQVAVWCIWWPAWLAGCVLHFSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ10</accession>
    <name>D4DJ10_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018815.1">
        <property type="nucleotide sequence ID" value="XM_003018769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ10"/>
    <dbReference type="GeneID" id="9581375"/>
    <dbReference type="KEGG" id="tve:TRV_07175"/>
    <dbReference type="HOGENOM" id="CLU_006533_5_0_1"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="387"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="727" mass="80545" checksum="43CAF4ED3BAB0C85" modified="2010-05-18" version="1">MNCTICHLRDCRKDGGGDVSYRLLLSEAFLVEKGQKLTGLANQMQASNFNIFTGRYTGTPSTSLLAYDAIKSDIPIICVSAMSGRRLLDAISFFNASRGVAKKHIVLQRHALDRHARTSSLTKEAKTQIQRISLAVQAASDLARKLDDDPTPGVTLADYNNARGRGVSRSEPSKVDDNTGTTGTKIESTEAPGVGVKAGFSTVPDEGPNSEQKEDVATNEENEMSDEMMQQLFRSRKVTRSLFKNQIHKPGQVNLKSETIPVLKPQTVGPEAVLETKTQAEGVKLDSAGNAEVQSDVINTNNVAPQDAYQMVQSRVPSSRIGRLWEYGGLATSMAMGVVGAGFRRATGGDDSGSLLLSPANIERLVAKLSKMRGAALKLGQMLSLQGPNWRDLFESFDEVPMAAASIGQVHGAVLKETGQRVAVKVQYPGVADSIDSDLNNLSILLTASRLLPKGLYLDKTIANARTELAWECDYIREAECGRKFKELLKDDTDIFTIPEIIPYASGKQVLTMERLDGIAVTRVHSFTQSQRDWIGSQIMRLCLREIGEFRYMQTDPNWTNFLYNSATNRLELLDFGASRAYPAAFISLYVRLLAAASRNEREKCRELSQELGYLTGFESKAMVNAHVSSITTIAEPFMKSSPEVYDFRDQTITDRVREFIPLMLRERLSPPPEETYSLHRKLSGAFLLCARLGSRVRCRDMFEEMLEKVEFVDERYKGRDDIPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ39</accession>
    <name>D4DJ39_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018769.1">
        <property type="nucleotide sequence ID" value="XM_003018723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ39"/>
    <dbReference type="GeneID" id="9581164"/>
    <dbReference type="KEGG" id="tve:TRV_07204"/>
    <dbReference type="HOGENOM" id="CLU_891950_0_0_1"/>
    <dbReference type="OrthoDB" id="4174095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056313" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32317" checksum="5406C1B920D25D9E" modified="2010-05-18" version="1">MGIFLHILFLLSHNAIHSLALDCRPVRIDGPSVGQRSNYTWEEGLPIQFGGWSDEEIKTCIGKADAYNIWLVSEDPDCPVVWPVFDTFLPKEDLKWSPFHFDLRKQTNEWYVDETLFARSQAFFIHGDGDEATTLYTTITSTSTSSYTTLTTATSTSASESSVPTIATVVVTRTLEPTATGPVPISHEKAGLSTGAKAGIGTGVALGSIAIAAAVYILILLRRRRNSDKVIPMVSGKDSNKYSPPGPPEMHDEVPGSLPVVSETNDPQKRPASEMLGSIPVGKPTGRVGDDIVHHELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ71</accession>
    <name>D4DJ71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000425">
        <property type="protein sequence ID" value="EFE38087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018732.1">
        <property type="nucleotide sequence ID" value="XM_003018686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ71"/>
    <dbReference type="GeneID" id="9581127"/>
    <dbReference type="KEGG" id="tve:TRV_07237"/>
    <dbReference type="HOGENOM" id="CLU_007003_4_1_1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="540" mass="60344" checksum="4AE4AB812A0788B0" modified="2010-05-18" version="1">MKMNGPYFSEILLNAILSHSLRWCRDEPKIARMLDAYDGGQQFRQRAVTGLFESLKGGNGQITVVQTLLLLSAQECGRGNRTQAWLYSGMAFRLLEDLGITIDSRKYSGSVQFSDEDVEIRNRLFWSCYFWDKLVSLYFGRSPIIQDTPVSPPRILLDDTAEIEIWTPHGVVFPEGMHYPPTQAHSTSCFMKMCSLAEILNQIIIHIYDPVRQSTESQIQECVDKQGANLEKWWNELPPFLKLIPNNLPTYCPPSHVVTLKYVICPCSSSVPLTNSSISCIYHTTNILLHRPMLCSRPFRSRANAASNANHLVQCLSSASSNITLYDLFRRTFGDSHVVLSLAYSLYTAASIFILEIQALKYASPSTLEKLRYCILALERVKAANPANLELVIHTALGLIEKELKKLRINIFDTPANPDQQTIPAVSPQTTTSSPPSSLDPLHSQHMYTLPPHGAFSITPPPADPQQAHQQQQQPLPHQNTTFMMDTPPLPDPPDFIAQDRMYEIAPELFEAFSYAEPNTPGGVGAGFDSTNWAGTGPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJD6</accession>
    <name>D4DJD6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000435">
        <property type="protein sequence ID" value="EFE38037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018682.1">
        <property type="nucleotide sequence ID" value="XM_003018636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJD6"/>
    <dbReference type="GeneID" id="9580835"/>
    <dbReference type="KEGG" id="tve:TRV_07302"/>
    <dbReference type="HOGENOM" id="CLU_064525_1_1_1"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="224" mass="24435" checksum="236B79CF010AF8F5" modified="2010-05-18" version="1">MSNQNNISIAMTNRSLRNIRTELEFLADSSVITPAQLSSILEQLPSQTQLHAPLHQPVTESTFSPPAAQLSRVSLNEKAESPYSSPPPPPTYSSAPPVLSLASALYAYTPTDAGDLALQPNDRIQVLEHMNNDWWRGRNERTHLEGIFPRTYVSVIEEKPIIHSPQPISYNNMPLEISQSGSSSHGKVPSKFEENGKKFGKKMGNAAIFGAGATIGSNIVNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJT8</accession>
    <name>D4DJT8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane channel protein (Aqy1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018510.1">
        <property type="nucleotide sequence ID" value="XM_003018464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJT8"/>
    <dbReference type="GeneID" id="9584439"/>
    <dbReference type="KEGG" id="tve:TRV_07456"/>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="173"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="91855" checksum="635F97AC18A16E63" modified="2010-05-18" version="1">MAQDLGTKYIPGHTLAKNFGVEYVILYSFEDQDASRELQRLLRTLYSVGLEAAVRPGKGQCLVVLVRPREDKLKAMAYRTRIKDWLYGVRTSQPTKDINDTQGVPWTEAERLRTIYDMMTLPRADGGADITPGYGYWKNVKSIFPLHDHDMNSEWIKSWSRKTLLDNDDLEQIRVKLGEKVAFYFTFLQTYFRFLMVPAGLGLFCWVFLGHFSIFYAVLNSLFCLVFVEFWKRQETDLRLRWQVKGVSEIKARRKEYKHEKEIIDPITGETVYVFPASKRLVRQLLVIPFTMAVVVALGTLIATCFAIEVFINEIYSGPFRTYLVCQSLPLTRFLYQTANKQQAFVPTIILSLCVPTISAILTKVATQMTEYENYETQDSHDIALTRKVFILNFVTSYLPIFLTAFVYVPFAPTIVPYLDVFHLAVKPFQPNEKGATTASAATEIKEFRINRARLRNQVIYFTVTAQIVNFALETVVPYVKRKFFRKYEEMSEARKNKEDSKSASSSSTDLLLDDVPEEAEFLKRVRNESELSDYDVTDDLREMCVQFGYLALFSPVWSLVPVSFLVNNWVELRSDFFKICIEYKRPTPFRADSIGPWLDSLSFLSWMGSLTSAALVYMFSSVAGAGNDEPHDDIKGWLLLLTIFFSEHIYLLARLAVQVAMSKLETLDTRRDRAERYLMRKGYLDRASSGHANINDTDENHYQRRGEEMLAEVQASAGVGEAVGDFDELGSDYVEEEIGQITRSSLEEDARKFSMPDATPSELFWARQQGWKESARIGAAIIQAGAQKETKEPKETKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJZ9</accession>
    <name>D4DJZ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II transcriptional coactivator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000447">
        <property type="protein sequence ID" value="EFE37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018466.1">
        <property type="nucleotide sequence ID" value="XM_003018420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJZ9"/>
    <dbReference type="GeneID" id="9584397"/>
    <dbReference type="KEGG" id="tve:TRV_07519"/>
    <dbReference type="HOGENOM" id="CLU_104273_0_0_1"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="177" mass="19320" checksum="B075F17EF1640F29" modified="2010-05-18" version="1">MGLKRGKRASSEDVEPAVSEDRSKRAKTAGDAGKAGPNAQISSTLDKAPKTDSNGDPYWEISRQRRVTISTFKGRVLVNVSEYYEKDGQELPGKKGISMTLEQFNSLVTLLPEISAVIEQKGGKVTRPDFSESAATIGEEDEEMSDVDEEKSKSNSKAKKPSPTKNFEATSDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK12</accession>
    <name>D4DK12_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000449">
        <property type="protein sequence ID" value="EFE37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018454.1">
        <property type="nucleotide sequence ID" value="XM_003018408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK12"/>
    <dbReference type="GeneID" id="9584383"/>
    <dbReference type="KEGG" id="tve:TRV_07533"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="46"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="591" mass="65421" checksum="CEDCD519D9E66E60" modified="2010-05-18" version="1">MATWEQKDGPLSETMQTKEEFSDQTGEIQYESDPNTSLHRGLKSRHITMIAIGGAIGTGLIIGTGAALAKAGPGSVFISYLIVGFVVWIVMSALGEMAAWLPLASGFTGYAVRFCDPALGFALGYRLVTTCTCMNAVLFFFFTLSLLTCCDNSYYCKYIIITPNQLTAAALVIQYWVKRDKVNPGVWITVFLIVIVAINYFGIKFFGEFEFWLSSFKVIIILGIMLLTLILALGGGPDHDRKGFRYWKDPGAFNTYLTHGASGRFLAFWSTMVQATFAYLGTELVGVTVGEAQNPRKTIPRAIKLTFYRILFFYCLSILFLGMVVPYNHPDLLFANKSSNSASASPFVVAIQIAGIKVLPSIFNACILVFVFSAANSDLYIATRTIYGLAREGKAPAILARTNRSGVPIYALALSTMFALLAYLNVSDDSKVVFGYFVNMVTMFGLLSWISILVTHIYFVRARNAQNVSETSLAFKAPLGVPGSYGALAFCILIGLTKSFNVFAHSPKTYGNFDYKNFITSYLGIPIYLILLFGYKFYTKTSGVKAAEADLWSGKDEIDREEAEFLAQEALRREQQGDAGWFYRTFVSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK39</accession>
    <name>D4DK39_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018432.1">
        <property type="nucleotide sequence ID" value="XM_003018386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK39"/>
    <dbReference type="GeneID" id="9584361"/>
    <dbReference type="KEGG" id="tve:TRV_07560"/>
    <dbReference type="HOGENOM" id="CLU_168399_0_0_1"/>
    <dbReference type="OrthoDB" id="4199986at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="92" mass="10316" checksum="1F359503E667E563" modified="2010-05-18" version="1">MTSRPTCNPLPACPNPIKWGVEGRIAELQAIVDTPQIKEGQKINLQAAINLYHEKKPPPPPPSLFKKGKVISLQDLNTTYPFWIEVMLPPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF0</accession>
    <name>D4DKF0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018327.1">
        <property type="nucleotide sequence ID" value="XM_003018281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF0"/>
    <dbReference type="GeneID" id="9580011"/>
    <dbReference type="KEGG" id="tve:TRV_07672"/>
    <dbReference type="HOGENOM" id="CLU_174231_0_0_1"/>
    <dbReference type="OrthoDB" id="5243597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="85" mass="9533" checksum="C6847EF76330601C" modified="2010-05-18" version="1">MTNSITSTSTSNSTSTSTSTIDKLKAFTHSFTRNKETKVDFYLKNYGFVPKNVMTEAEWAKARRDAPKVKSATGLKATAYQGHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH7</accession>
    <name>D4DKH7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018295.1">
        <property type="nucleotide sequence ID" value="XM_003018249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH7"/>
    <dbReference type="GeneID" id="9579991"/>
    <dbReference type="KEGG" id="tve:TRV_07699"/>
    <dbReference type="HOGENOM" id="CLU_037985_0_0_1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="189"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="41260" checksum="41AFE6289D374DC0" modified="2010-05-18" version="1">MSAPSEPPSRTSTPRSFTNQSTTAEDLFKSQTVGLVKLSDYRKRRAEVLEQKEREAHDKSLGRFTPGTSRSGTPSAGDKADGEQSDEPLKKKKKKVRALAKSKLSFGNDEDEGETEDTPNISRDPSERRSRSGTPRESSPKPSRRLAPNPHLTLPRPKLVTKSALEAESKARDALWREFLALQEVVKATEIVIPFIFYDGTNIPAGQVTVKKGDPVWLFLDRCRKVGAKLGLAGAGGAARGRKDHRREWARVGVDDLMLVRGGVIIPHHYEFYYFIANRISNFSGNGGLLFDYSDAAPPTSSDNNSNATPVLEGKDADPTLTKVVDRRWFERNKHIFPASLWREYEPGPEFEEKMRGVRRDNQGNAFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKJ0</accession>
    <name>D4DKJ0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018262.1">
        <property type="nucleotide sequence ID" value="XM_003018216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKJ0"/>
    <dbReference type="GeneID" id="9579872"/>
    <dbReference type="KEGG" id="tve:TRV_07712"/>
    <dbReference type="HOGENOM" id="CLU_030506_1_0_1"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="80"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="367" mass="41217" checksum="8A161C57EFC80D69" modified="2010-05-18" version="1">MKEAPEDKRAELETQASIGAAWDFPEISIIPHTSTDRQHAAAHDEAISIHALEAERELISEEPDKKALLEEEETQKTILYLAYGSNMCAQTFRKTRKVTPLSQANVYVPNLCLTFDLPGVAYLEPCFAGTQYRDQKTGMPIYPGKPQSPSDGEGLWHKPLVGVVYEVTMKDYARIIATEGGGASYVDVVIDCHPFPEDYDPAKPVPDIPDTEPFKAHTLLSPATAGKSHRKGTEKKSSLFNARFNRSRPNYARPSPRYMKLLITGAEEHDLPAEYRQYLASVEPYRPTTSRQRVGQFIFGVVWVPPLLLNLRLNAIFANEDGKAPGWLAVFQRYIFAGAWVTYDYAFKYIFGDGERTIPQRTGVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKQ5</accession>
    <name>D4DKQ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018204.1">
        <property type="nucleotide sequence ID" value="XM_003018158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKQ5"/>
    <dbReference type="GeneID" id="9579575"/>
    <dbReference type="KEGG" id="tve:TRV_07779"/>
    <dbReference type="HOGENOM" id="CLU_053539_0_0_1"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="51"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="415" mass="46833" checksum="EBA728316EF2D459" modified="2010-05-18" version="1">MLQWRLLLAGLYPVEFRDFFLGDMYCSQTYAMGNIALFFCLYANKWDNPPMCNSSHSRVFGFVTTIPSIWRGFQCLRRYYDTRNAFPHLVNFGKYSFSILYYLTLSLYRIDKSTTLRGIFITFACLNAIYASVWDLAMDWSLCNPYSKNPYLRDFLGFRRRWVYYVAMVIDPILRFNWILYAIFIHDIQHSAVLSFAVALSEVCRRGMWTIFRVENEHCTNVGRFRASRDVPLPYDISMTVSDEEAISSIPGASTSYKGRESRGSLPHALGRIPTGGTAVSSGAASQMPDLESGDGGDESTSSLRRRRYSQREGGTPPSGTLARVGTMLATAHAQDFERKKRPSILDEGKDSPNNGTSTDEEEEEEEEENGGNDNNNNGYEGHISEESDQSSGNREGKSGSNSGTYSNRASRHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ8</accession>
    <name>D4DKZ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000485">
        <property type="protein sequence ID" value="EFE37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018115.1">
        <property type="nucleotide sequence ID" value="XM_003018069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ8"/>
    <dbReference type="GeneID" id="9579324"/>
    <dbReference type="KEGG" id="tve:TRV_07872"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="65"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="586" mass="64326" checksum="004254B60D98FB40" modified="2010-05-18" version="1">MLPPFDYFQYRSARNFKRNQRSQRFASLPSVYHAPFSAFDQSVIDKPIEELVQDVHKGALAPVDVLHTYGKIAIKAQERCNCITELLIPESEEWAKSGINLQGPLAGIPVSLKDSIQVGGFDTSVGYTRYTRQPAAKDGALVRLLKDAVSLSDMIQGAVPYAKTALPITLLSFESTNDLWGVCRNPHGSAFTPGGSSGGEAALLAMGGRIGVGSDVAGSVRLPAAWSGCYSLRCSTGRWPKAGVSTSMAGQEGVPSVFSPMARTLNDLTYFARSIIGMEPWKYDTTVHPIVWRSEIEDEAKTKKLRIGVMSSDVARGINTTVAALTAAGHTIVEVKEPETATSLMGLNLASLLLNSDGCETFNSHLQTGESSDPGAAHLTTFSWFSWPFRYAYYLFVRYIKRDPTWAYLLRDFGLKTATQQWKLVAQRETFRATWHDWWNAKEQDFDFILCPVNATPALPHGAMTDAVSACGYTFFWNMLDYSAGVIPVGHVDAKRDALVGPDGKKGKNVYKRVLKNLGVDSAVSRGAWKYYDADAMHGLPIAVQVVGRRWHEEKVIGCMHAVERALEEYKGPGGDGGKYQLLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL08</accession>
    <name>D4DL08_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000487">
        <property type="protein sequence ID" value="EFE37461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018106.1">
        <property type="nucleotide sequence ID" value="XM_003018060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL08"/>
    <dbReference type="GeneID" id="9579320"/>
    <dbReference type="KEGG" id="tve:TRV_07882"/>
    <dbReference type="HOGENOM" id="CLU_012970_2_0_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000510">
        <property type="entry name" value="Siderophore iron transporter mirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="618" mass="67919" checksum="ECCD49BC71466B98" modified="2010-05-18" version="1">MDDTAEADRLLQDTDDAEGVDEHLHISPYPSSLDSEVQDGVRKIEAISKTWTQRSLVIAYLGIMLMAFCTSLEVQTVASLTAYATSSFSKHSLISTVLVIQNVVNAVIKPPMAKFADVFGRFEAFCIAVFIYVLGYIQMAASQNVETYASAQIFYSAGSTGLQILQQVFIADSSNLLNRAIFANLPDIPFLFTVWLGPMIASWVLKQLNWRWGYGMWAVLLPSAFLPLALSLYINQRKAQKLNLLKSKPWKGKGLKKVLRSAWFELDVFGLILLSAAVTLILVPLTLAAHAKDTWRNGGIIAMIVIGGVCLIAYPFWETSKRLAPHPLLSLGLLRQRSALAGCALAFFYFMAFYFSVQPYFYSYLQVVQGKPVVTAGRITQTFSFMSTIAALVVSFMIKYSKRYRPFVTFGCVVYILGLALMLLTHKSGKSTLQILVVQSIIGLGGGLVNVPVQLGVQASANHQQVAAATAMFLTALEMGGAVGSAVSGAIWTSYLPHKLVKYLPDETKGEATEIFGKLTKALSYPMGSPTRDAIIRSYEETMQILLTIALCACIPLIPLSLLMKNYELDKVDQRVKGKLIGNIGDSDDASPVTPELSAFPPPNLRPTKRRSQHHLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLP6</accession>
    <name>D4DLP6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin remodeling complex subunit (Arp9)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017864.1">
        <property type="nucleotide sequence ID" value="XM_003017818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLP6"/>
    <dbReference type="GeneID" id="9583759"/>
    <dbReference type="KEGG" id="tve:TRV_08120"/>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="68892" checksum="D4560D116815D5D1" modified="2010-05-18" version="1">MFPAEKKGEWEPHRIRGRVVKVRKVVSPKPAAPATESSVHASDEGAAAASGSTAEDSSKQDIEMKDAADDKAKETQATGEIGEKPAEAVEETEEMTVYEEDTMSDEGAVYALHNGAVVDWSCFFALLTHVYNTLSPPFHTPMIIIAQPVWTAADRERLTQFVFEKFKTPAFCLMDSALAVCYAYNTPNATVVDVGHGKADVTAVTDFIVSEHGRGIALEGCGGQALTDRLLELLGPKGFTREMCEKLKRNPICEILPPGTPLPKDNGSDSANQESIKQAPAPGMGPDMPRGLGNGEKEDDDGVLDVASIVSRGNASEFIAKREKEKAEKAASRKGQAAESAAARQARLPNSKKARAIFHYEGLAEPHAGANDQTQPTKQKKEIEVGVERLMAATPLESGADERCGYSILETLAAQIHHTILSVPDASTRSSLWDSLIILGNGSKVKGFPQALLSTITQKYVLSPSSGTIFTSEIPSTFSTPLATGANTPAQPQNPGPYLHPAAHGVNPLLVAATHSNTPATPNNLNSNAALSADPNMLAHHKSTGHSQTPTGIKLLKPPEYFPEWKEQGSSSAAAAVPGTNPPANTDASNANAATGVASGSNNVGMEEATFLGAQVAAKVIFIVDQGASKGYLSRVEYNDAGPTAIHKYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ34</accession>
    <name>D4CZ34_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025744.1">
        <property type="nucleotide sequence ID" value="XM_003025698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ34"/>
    <dbReference type="GeneID" id="9582002"/>
    <dbReference type="KEGG" id="tve:TRV_00071"/>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="40"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE45133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="645" mass="72497" checksum="B08042229A5FE534" modified="2010-05-18" version="1">MMATGPASFHDEDSRPSSRFTYRHFQLLRSFSTRTPLRVIAHIDLDAFYAQCEMIRLNTPRDQPLAVQQWQSLIAVNYAARPFGVSRMITAAEARKLCPQLLTPHVATFREGEGENWAYREGDYSVQKDKVSLDPYRAESRKILAVMKTTLLTWAEGIYEGCRGQFSDPSDMVRLEKAGIDEVFVDLSALVFGTLLHRYEILRRAATPDGSKDGPNTFLPRPETTALIWGEDDELIDLDTGESEEDDPEWDDIVIQVGAEIVKFVRTAVWDQLKYTCSGGIARNKMMAKLGSACNKPNRQTIVRNRAIQQFLSGYKFTKIRSLGGKLGKKISSEFETDKISDLLTIPLDRLKNKLDDDTGMWLYQIIRGEDDSEVTPRTEIKSMISAKSFNPKLASLDQAEKWMRIFVAELYGRLVDEGVLENKRRPKMITVHHYGPNQDKSRQTHIPTGGAIDQVMLFELAKNLLQQVVSWPCSHLSLTVSGFESGITGNKSLDSFFIRGAGETSVSQRDGSMPNGNCQPELPDDNSGHQRKKQKVGEVHSQPPSKGVGFFSRYKTSAKQTFIEPCSENTGESLANLQTNPTSYYSTQDVCSRCGEAVPEFMQSEHDDWHLAKDLESQEQQSLNAARARSTSTGKTRQTRLAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ40</accession>
    <name>D4CZ40_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025750.1">
        <property type="nucleotide sequence ID" value="XM_003025704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ40"/>
    <dbReference type="GeneID" id="9581981"/>
    <dbReference type="KEGG" id="tve:TRV_00077"/>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="103"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="445"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE45139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="638" mass="68926" checksum="B24D88E392530231" modified="2010-05-18" version="1">MPSILDDDDDRDLIGSQDGSSDGGMDDTMQDMDDMEVDVEPEPEPEPEPNSPSNSSVVDSEHHARNAQNPEVIITAPALDPVPDQPFMYRPQVRPEVLTAATYDIVPTTAAPHSTSINAVTSTADMRWVFTGGSDGYVRRFNWVDSINSKLMLTVAQRHPFVDSVVKAGVLVNYWENMDGTAMSPVYSLAAQAEGLWLLTGLESGFIRLQSVRHDEGKEIAVLKQHTSAVSVLSLTHDERSLLSGSWDKRALEWDLDTGKVKRTFGPSIGQVSAIEFRPESSLPVPREIVEKPLTNGTYSSNNRAAPSTNQSFVNGGGNNKDGQIGDQPGSPADSLFEADSLFGDAEGGGDADAPSGGAFAAEDDEFSQALANGIKQKQQVPRKDADDSTSNAMPNGIVSNSESLIESIPESGSTSQLQTTKQEPEDSQVNGISDSVMSGLPHAEDMESSAATMEKGATASDMNSLGNSNSTFLSASIDGTIRVWDRRQSDPIARITPRNSPPWCMSACWSPDGNYIYAGRRNGTVEEYSLHKGLRDPQRTFKFPHGSGAVSSVKIMPNGRHLICASHDILRLYDLKEEQSSRSSVPFLIIPGHRTGTISQLYMDNACKYLISTGGNRGWEGSTTEVLLGYEISSLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZC1</accession>
    <name>D4CZC1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025640.1">
        <property type="nucleotide sequence ID" value="XM_003025594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZC1"/>
    <dbReference type="GeneID" id="9581879"/>
    <dbReference type="KEGG" id="tve:TRV_00163"/>
    <dbReference type="HOGENOM" id="CLU_072097_2_0_1"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE45029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="151" mass="16837" checksum="39265741ABC881D8" modified="2010-05-18" version="1">MSQLNKWMLGGKISKLVIVITDKDTGEHVERWQFDVEIFKQSKNKAAKAAADNENANPGAQASSPAPVEKSEKEIQDEIQAIFRQITASVTFLPMLDGNCTFNVLVYADADSEVPLEWGDSDAKEIENGEKVQLRSFSTSNHRVDTMVSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZL1</accession>
    <name>D4CZL1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE45002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025613.1">
        <property type="nucleotide sequence ID" value="XM_003025567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZL1"/>
    <dbReference type="GeneID" id="9581851"/>
    <dbReference type="KEGG" id="tve:TRV_00253"/>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15047" checksum="8F856CC467876BB1" modified="2010-05-18" version="1">MLIRYVSSVGDIVDLKVNGAVQKGMPHKDFHGKTGVVYNVTKSAVGVIIYKRVGNRYIEKRVNVRIEHINHSRSREEFLNRVKENAVKKRKAKEEGVHVHLKRQPVGPREARVVSLEGNAPETLAPLPYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0F9</accession>
    <name>D4D0F9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000031">
        <property type="protein sequence ID" value="EFE44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025277.1">
        <property type="nucleotide sequence ID" value="XM_003025231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0F9"/>
    <dbReference type="GeneID" id="9580769"/>
    <dbReference type="KEGG" id="tve:TRV_00554"/>
    <dbReference type="HOGENOM" id="CLU_058490_3_1_1"/>
    <dbReference type="OrthoDB" id="4169385at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="31666" checksum="77A035EDA885D23B" modified="2010-05-18" version="1">MADLNRKAPETIDSPLLIGLPEGTLQIEYTNMEDIRCLVDKRAQLCCLDSSKSPFIIVINIPHTFLQDFDNVYLDKGPKISTNLQDRVLILETMVAKEHEVAARGLEGYLRERIRDMKLNYITTCSGASRATSDTFTKEPDGSFTLQDRDWPILAIEAGVYECESKLNIDARGWLESPKSETEVVITIKIERLSPEITFKKWEKSSSTPERGMCSYQPAISTETIHVKYQNDVTEITGDMVIPLAKIAGRGPQNSNENDITVTKAAFEEICKEVWTTQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0G5</accession>
    <name>D4D0G5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025244.1">
        <property type="nucleotide sequence ID" value="XM_003025198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0G5"/>
    <dbReference type="GeneID" id="9580744"/>
    <dbReference type="KEGG" id="tve:TRV_00560"/>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="80537" checksum="C56779B9ADE52525" modified="2010-05-18" version="1">MHELSSMSDLPPPYPSEQPKDGIDTADSASICDDDDGAEQDKLLSTASRIPEEDEERPCLYESAQESFAKDPFRPFPLPGSSSARNEKKILTFRALLVGISCGALVNASNIYLGLRAGWTSSANIFGENNIVQTAATAAGGLSSVFVSAFPAMYQLNLLDTPWRDFLRVTVLTAAGGYFGLFFATPSHIKVRKFFIFQVAKELNLVFPSSSATAITISGMHLAAGGSRLARRKMVALASAFAFALVLRVMSQYAPGLLWDWHIFTWLALSGVLPSTMFAIQSWGWFIEWTPAFIGTGMLVDMNVALSFVFGSVLAWGIVGPTITKYGLAFGEPVSTDSKWDGLVSYISFSKEFANATHPSPRYWLLWPGVACMIVVEFTELACQWRVFWLTGVEIYKACNNILSRLQENRHKYKHLTEEDELRTNQAMDGGIKTWMWLPGLIAVLILTCVVSRLQFDIPVASSILSLVLAFTFSVIAIQSTGATDITPLSAISKASQLVLGATTRGPEWKLESSQRVNLLGGALASIGANQACDLTGDFRVGFLLNTPPCTQYAAQAIGTFFAVFLAPAVFSVFASAYPCILSTGDEPRSKNGTTGQTCPFTAPAASAWRAAAVAVTDPEFPVSKTSVQFSIIMSAIGSIVVLVRHHLWIGKWAWMRNYHPNMMTMAMAFLIPTTQYSTAMLIGTVIAMVWKRRNSGSFESYAYAVAAGFMAGEGIGGVINAALTIIGIDGAHLGTSIGCPGGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1H3</accession>
    <name>D4D1H3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024918.1">
        <property type="nucleotide sequence ID" value="XM_003024872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1H3"/>
    <dbReference type="GeneID" id="9580409"/>
    <dbReference type="KEGG" id="tve:TRV_00923"/>
    <dbReference type="HOGENOM" id="CLU_033563_0_0_1"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="46874" checksum="8404C87590447C60" modified="2010-05-18" version="1">MSLPTHCTDAPAKDSASISEAHDIIIPAPSMPYNDGSIATSSVSQDSCSTVATFPWSPEAGNADVMLQNINDETFPALEMSASMGWNENFLPENYPSEYHSELLSYFSQIPEQHNIPKLPGPGEPLSLPQVPPLLSSSGASSSIGLGLSPNGDFSCDEDLFANNFLPGHSTVSSNTGELFEELSQRGGMAEPLGIALACASAYDSCVESSSSFIDTMINTQREKLIREFHLYVDQPETCLAALHAVSVYQILSSLGDRSTTTGPVEVDRPQTGSGLAAEFHISFLLKMTRRLCSLYKEAVTSDTETDWNRWKFAESLRRCVFFVNLINVLAARCRRFHFDYFEPLDDTLILQMPLPTTEQTWRAGNETQWQICREDTQIIRPAPTLQKLMEIDDAGQLDRATLTPLTRIILACARVDLEADWRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1I2</accession>
    <name>D4D1I2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024927.1">
        <property type="nucleotide sequence ID" value="XM_003024881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1I2"/>
    <dbReference type="GeneID" id="9580418"/>
    <dbReference type="KEGG" id="tve:TRV_00933"/>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="216" mass="24561" checksum="C350E4170475D0B4" modified="2010-05-18" version="1">MSDKKSFYNKPVSDTSFRKTWDREAYTEKAAADEAKSKEEAKARYEAKLQGKKYHAPVDFSSLEATTSRASRLDVASLVGKTTLVPAGAAVGKRGRGAGFYCSDCDLTFKDNIQLVEHLNSKQHLYATGQSGEVVRAGVVEVRNRLRWLAHKKRVQEEEDRKAGQLDLDLRIKTREEEEAKEREEKRRKRNEKRRKSGKDGVKQEDAWEGRLGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Z0</accession>
    <name>D4D1Z0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024743.1">
        <property type="nucleotide sequence ID" value="XM_003024697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Z0"/>
    <dbReference type="GeneID" id="9580233"/>
    <dbReference type="KEGG" id="tve:TRV_01092"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="176"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="340" mass="38689" checksum="1E912CCD62EC0D8D" modified="2010-05-18" version="1">MSQIPVIDFAPFRDGSPEDAEATGKKIFEAFRDVGFVYLKNHGVPQEVVDEAFSWSKKLFDLPQSEKEKAPHPPEGWWHRGYSGIGREKVTQMVFDSDTLGELRKIPDVKESFEMGREDDETTPNIWLPESTIPGFRAFFNNFFEINHDVGQEILRAVAIGMGLDRDFFESYHTMKDNQTRLLHYPPVEEEMLRQGEKERIAAHTDFATMTLLFQDDVGGLEVEDIHQTGVFNPVPYIPGTMVVNIADFLMRWSNDTLRSTMHRVRAPPVVNVDENGQEKDGDSGGQRMSRARYSIPYFIVADKNKVIDCLPGCYGPDQPKKYEPIASGDYIAMRLNAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D243</accession>
    <name>D4D243_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024682.1">
        <property type="nucleotide sequence ID" value="XM_003024636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D243"/>
    <dbReference type="GeneID" id="9582857"/>
    <dbReference type="KEGG" id="tve:TRV_01145"/>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="703" mass="79880" checksum="95422055761EABC6" modified="2010-05-18" version="1">MSETFEFQAEISQLLSLIINTVYSNKEIFLREIISNASDALDKIRYESLSDPSKLDSNKDLRIDIIPDKENKTLTIRDTGIGFTKADLVNNLGTIARSGTKQFMEALTAGADISMIGQFGVGFYSAYLVADKVTVVSKHNDDEQYIWESSAGGTFTLTQDTEGEPLGRGSKIILHLKDEQTEYLTESKIKEVVKKHSEFISYPIYLHVLKETEKEVPDEDAEEVTEVEEGDEKKPKVEEVDDEEEDKEKKKKTKTVKESSVEEEELNKTKPIWTRNPADITQEEYASFYKTLSNDWEDHLAVKHFSVEGQLEFRAVLFVPKRPPFDLFESKKTKNNIKLYVRRVFITDDATDLIPEWLSFVKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKTLELFNEIAEDREQFDKFYSAFSKNIKLGIHEDSQNRAALAKLLRFNSTKSGDEITSLTDYVTRMQPHQKQMYYITGESIKAVQKSPFLDSLKEKGFEVLYLVDPIDEYAMTQLKEFDGKKLVDITKDFELEETDEEKSAREAEEKEFEGLAKSLKNVLGDAVEKVVVSHKLVGAPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMASKKTFEISPKSPIIKELKKKVEADGENDRNVKSITQLLYETSLLVSGFTIEEPAAFAERIHKLVSLGLDVDEEETPEEKATEETPADEPAAASAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D252</accession>
    <name>D4D252_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024691.1">
        <property type="nucleotide sequence ID" value="XM_003024645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D252"/>
    <dbReference type="GeneID" id="9582866"/>
    <dbReference type="KEGG" id="tve:TRV_01154"/>
    <dbReference type="HOGENOM" id="CLU_013430_12_1_1"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="162"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="56192" checksum="D8719BCDF965E9B4" modified="2010-05-18" version="1">MIRTPAGCGKTRFRSARLLCALVRPRPPQPPRDSDIQLRGFRLPLRLVRCHSSLSSLSSLSSLSSPSSSSSVVAAKNPPRPPAYPPASPALSIIITARPARPVLALVHSHSHSHSPFTMGGQTRSHGHSHGHGHGHHHHHHHDTTYLTSKNKQDPGVRITRIGLLANLAMAVGKGVGGYVFHSQALIADAYHALADLVSDFMTLGTVSWSNKPPSARFPLGYGKIETLGSLGVSGLLLVGGLLMGLNAAEVILTQFFPDVAEAAAHMGLLGHGHSHGHSHSHFPSDQAYGPNINAAWLAAGSIVVKEWLYHATMKIAKERKSSVLASNAVHHRVDSLTSIVALLTIGGAHVFSDATWLDPVGGLLISIMIIKAGLGNTKATLLELADAGVEESMVDSVRKYAARAIAALPHGAEVELRNIQGVKSGPNYLMEVDLAVPGSWSVARTREVERAIRERVGARVRGVKRLRVRFTLDTEKELDFAEEFIAPDLSPRSSPEPEPETNGNGSISSGSQSEPQVNGTRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D298</accession>
    <name>D4D298_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">TRV_01201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024632.1">
        <property type="nucleotide sequence ID" value="XM_003024586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D298"/>
    <dbReference type="GeneID" id="9579959"/>
    <dbReference type="KEGG" id="tve:TRV_01201"/>
    <dbReference type="HOGENOM" id="CLU_048143_0_0_1"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="312" mass="34039" checksum="DF680D9ECE4029C7" modified="2010-05-18" version="1">MASNDLASEVPKSKVPVTHTGSQPPAHLLAIYPLTLILGSIYSRISPTANPSSPSSISSQSQEPVNYFARKGNAFNVYFVKIGWLWTSLAFLSLLLTQEAFTSKRISANCRLRRVGQALLRYLLVTFSWILTTQWCFGAPIIDRGFLATGGRCELIQQQMIDDPSQSDLPPAVVLTSVLCKASGGTWKGGHDVSGHAFMLVLASAFLIFEMMGTRSSVIISSGNVNGARGPAQRTTDKQVTACGPNDIGELLAELSRKFVWTIVGLSLWMLLMTGIWFHTWLEKVSPLPPFVYKLLLPVLLGFPPSFTNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2E8</accession>
    <name>D4D2E8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024541.1">
        <property type="nucleotide sequence ID" value="XM_003024495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2E8"/>
    <dbReference type="GeneID" id="9579764"/>
    <dbReference type="KEGG" id="tve:TRV_01253"/>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="716" mass="81462" checksum="E2AC66ED4578949F" modified="2010-05-18" version="1">MGLLYGPLHLSSSFFRRNDLLIDNRTGSALGTPLAWPEAKERAGQQLLAIWKKARGKERDALLWGDEVEYLVVAVDDKEEKVRLSLCQAEILKALAQDAELSKRAAVNGDASEYDLPDNVKSILIKEPLPTFHPEFGRFMLEATPGKPWGIGFKELLKVESNMKWRYGSPSRLCCYCEVESNITRRVTAKNHMAANEYPITLTTFPRLGCSDDFTLPSYPLSGPALRSQFVPDEIANPHIRFPTLAANIRSRRGRKVELNVPVFRDTNTPWPFKDPTVNYDLHKWPEDDDVRNGAAKEGNVYMDAMAFGMGSCCLQITFQCKNITEGRKLYDQLSPLGPIMLALTGATPIYKGFLVDTDVRWNQIGNAVDCRTREELGEVPLKNDRWRIPKSRYASNSTYISQDPHLRPEYMDPDLVIDEDIKKKLMDGGMDELLATHFAHLFIRDPIVIFNEDLQELDLTKTDHFENLQSTNWQHIRFKPPPADNDIGWRVEFRPMEIQITDFENAAFSIFMVLITRAILSFDLNFYIPIPRTTENMETAHARNAVLDEKFYFRKDPFPHRYPRSQRHQQSRPSSPPGGSTPSPPPSTTPSSPLLQPIESEYTLMSVNDIINGSPDGFPGLIPLVESYLDSLNVDVETRCALAKYLDLIRRRADGSLWTNAKWIREFVAKHPDYKQDSVVSAKISYDLVKAVEEITEKEGKDGSIGWEMFTAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2F8</accession>
    <name>D4D2F8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024551.1">
        <property type="nucleotide sequence ID" value="XM_003024505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2F8"/>
    <dbReference type="GeneID" id="9579774"/>
    <dbReference type="KEGG" id="tve:TRV_01263"/>
    <dbReference type="HOGENOM" id="CLU_018300_1_1_1"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="297"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="57871" checksum="C34EFD4413000433" modified="2010-05-18" version="1">MEKITEQWQRKKQTKEQARDAKRAKLDPESSKSAKDVMDENARKRKREETDKDETPDANSSHSEEEPLGSEKPREGLKRGDSKPKKQKKATATSSPEDHKAKDGDIKQQAKSEAKAAKQEMLKKKQAEKREKRKEKIAALKAAKREQQTSVEASSKPSKSKVDDTTEQPSPSVQKPAKSTAKNIKNSAESDGEMEDISLEGFSSEALQGQAGHESTAPTSPNNASDPSNPPSGSSSVSSIVPPTIPAPTIDNKSSPQLGKPQRTPEQIRERLQKRIDELRAARHADGVNGKPAKNRQELIEGRRQREEARRAQKKEQRQKAKEEEQRLRDEAISKRFSAQNPGSLLSSPASPADSIASIPNNFSFGRVVFADGQQLDSSMTGLRDAAKKRGPQDANTALKAAEAKKARLASLDEEKRADIEEKDMWLNAKKRAHGERVKDDVSLLKKALHRKEGLKKRSEKQWKERIDGVAKGKEIRQSKRDENLRKRKENKGVKSGKKVTKSKGKCRPGFEGGFKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Q3</accession>
    <name>D4D2Q3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydantoinase/oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024528.1">
        <property type="nucleotide sequence ID" value="XM_003024482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Q3"/>
    <dbReference type="GeneID" id="9579751"/>
    <dbReference type="KEGG" id="tve:TRV_01359"/>
    <dbReference type="HOGENOM" id="CLU_007154_1_1_1"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="210"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="76432" checksum="8170CBBAB06D54A4" modified="2010-05-18" version="1">MSSLAAPYRIGVDVGGTNTDSVILDVRATNEANRGVIAQHKTPTTSPNVTDGIETAVLNVREQSKVPRDQIACLTIGTTHFINAIVEHDARRLSKVAIIRLSKSFTREVPPFSDFPPVLKSIMNGYYTYVDGGLTIDGAAESPINETQVVKECAKIKELGLDAVVISGVFSPVDKHFFQEDNVRKIIQRELPGVDIVCSSEVSQIGFLERENASILNASILRFARRTIRGFKSAMKRLSLNCPLYLTQNDGTLIDAPSASRLPIRTFSSGPTNSMRGAAYLGLSGPDDTGNDRTATIVVDIGGTTTDVGVLLPSGFPRQASAYVEVAGVKINFGMPHVESIGLGGGSIVRHKGANTTIGPDSVGHYLSTKGTVFGGDTLTATDIAVAAGAKIGNPDLVKDLDKELVSAAQARVKTMLETVIDQMKTSPAPLPVLLVGGGSVLAPAELDGVSKVIFPPFHSVANAVGAAMSKVGGTVDSIESTAEKTVAEVVDEAKARAIEKAVASGAIRETVYLAEVDSMPLQYVANQVRVIARAVGELSPEGVLTLDNIRNGGDDDEGDDTIYNEVPKQNIETEEFSANTVDVATYRPKVVKNPQTGIDEWIVSETDVAWLADGCYVLGCAGGGSPFSEHIRIRDQIRQGHIIRIIDPYSVKKDAVIYCKLSQLRSRFDFDSTDASERGRSHGFSSCLCRTTSKQRDRTIHPCPYGVSQTWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2W2</accession>
    <name>D4D2W2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024455.1">
        <property type="nucleotide sequence ID" value="XM_003024409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2W2"/>
    <dbReference type="GeneID" id="9579677"/>
    <dbReference type="KEGG" id="tve:TRV_01418"/>
    <dbReference type="HOGENOM" id="CLU_057143_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000534">
        <property type="entry name" value="zinc finger protein 674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="319" mass="34761" checksum="B117DF057CAA09C5" modified="2010-05-18" version="1">MHQQSSSYPTTPQTCTQTDSISLQSSSATGLGLLNCSLPPAGTSASICSPSQSMLQVAQGWHGEPSAGHCFPNTSSSMVTYPIISIYDGLQVVPNASISSFGVPSTHVDTSSAGFLSPVPLMKVESSSTIQSNIYAPDMSSNYGVSPSPTQSPQILSEGMSDDWEIIANDNAAKQAFFSMEDLPLFHQQISSPVPARQPREANTPVLTSTPIHNQRKPRRSPLRTSDCNKVVGKRTSELDLSSPDMKMPPKKKRSLDNGNGKYECEQCGRQFTRNSNCRSHMKIHDPNRRYPHKCTIGQCTNKFSRKTDLIRHIDSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D317</accession>
    <name>D4D317_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024407.1">
        <property type="nucleotide sequence ID" value="XM_003024361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D317"/>
    <dbReference type="GeneID" id="9579629"/>
    <dbReference type="KEGG" id="tve:TRV_01474"/>
    <dbReference type="HOGENOM" id="CLU_086397_0_0_1"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="28410" checksum="889F042E89E8CC87" modified="2010-05-18" version="1">MDFKPQDFVHYLLAAAGAFPHDQPGISLISEEDGDLIEKLWTGTEIANQVFVASDVRKNTPGLYLLGEEERSILFVDKSDILQWYRYDPDEEEWSEVEYDNKGKLTVHQSSRLSGCLSPGGEIVIFEGPENGLQAYRVTDGEKFETLPPLPTDLEPGTPHQAVLLGDDTLHLLFPYPSSNHDEKIVSFIVIPQGDGSLELCALMSGGALVQVKANGQITELGTVKQGRFTAHTSEECGIELMLGIKKGIKAVAHKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D386</accession>
    <name>D4D386_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000081">
        <property type="protein sequence ID" value="EFE43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024296.1">
        <property type="nucleotide sequence ID" value="XM_003024250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D386"/>
    <dbReference type="GeneID" id="9579416"/>
    <dbReference type="KEGG" id="tve:TRV_01545"/>
    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="620" mass="69158" checksum="78403A4087D5BF77" modified="2010-05-18" version="1">MLLRLPPELIYSIAAFLPTASCLLRLAQTCRRLYTIVAADNYRIFQAFVQGQYPTAVAPPLWRDAAHALTLRSHAFRCRAVTARYVEPPSNAARIGKPKTTRRDKPTLGYRPVIDSYESWYGNHWFARKEVLAWGAGADVVLRIKDLNGHDGAGEASGCQQDTYDGAKWAVFNDLPSVNSWDDVAGLHLLGDDSSSVDSLDSEDLIVGRRNGELTRLSISPSQGSATHRAFFDTQGHKLDYTDLSVGTERVLAASLDRGEIAFYKLDSDTYSVQPFVSLKAHLHGASRNRCSKLLSNRRIVVGADGESSKIEVFSFDETDMKTECTIRIEDDEAERKPRVTAMAPLPALSSMKETSSQNLFLSGWEDSKIRLHDLRSPRPCVAVYGDTVDDSPVYSLLPIGHERLMVGSGAHGLLKLFDLRVTGRHHVDSNNTSPSIPKSNRRRRCSNSIVRGLQLNLPPGPPKDISIFLSDRQSENRNNTRLQRTLKPRYRGPVYTMSLPSPTSSTLYVGLVNTVMRLDMVGTDDLCAAGDNKSGLNWSSLNLSLPLDAKASPGHQPADLSCYERPFPEDNGRGIRLFVQKPFWSSSIVTHHDDNIPGWDQRWFQPSVNRNIKPEERWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3A1</accession>
    <name>D4D3A1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000082">
        <property type="protein sequence ID" value="EFE43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024281.1">
        <property type="nucleotide sequence ID" value="XM_003024235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3A1"/>
    <dbReference type="GeneID" id="9579401"/>
    <dbReference type="KEGG" id="tve:TRV_01560"/>
    <dbReference type="HOGENOM" id="CLU_2005561_0_0_1"/>
    <dbReference type="OrthoDB" id="4173556at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056140" evidence="2">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="124" mass="13207" checksum="8DC49F29E34EB4FD" modified="2010-05-18" version="1">MRVLYWIFAAMPLAMAAPVALPNENAPGMLNIGPRAQDEASDINHIPINSVENLCPENEHADECGGGQPLGHHEMNNGESPVRKQHGDVESDLRRGSLLPRQSKGRLLSGALIDGLPLLGSGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3B2</accession>
    <name>D4D3B2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_01571</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024221.1">
        <property type="nucleotide sequence ID" value="XM_003024175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579259"/>
    <dbReference type="KEGG" id="tve:TRV_01571"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="568"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="223"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="435"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="760"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE43610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1289" mass="146465" checksum="8C652C7812FA5C76" modified="2010-05-18" version="1">MECSRDSRDALLIVQSEGGEKTNEKIDNHQIPSHDEITQEEVEAAREVAMGKLIRLELFNFKSYKGHHTLLFGDAYFTSIIGPNGSGKSNSGRVLRTAKINDDGSASKDPAAGESGAQNGEVAEEPAERNDPKSAWVMAVYEDDAGEEQQWKRSITSQGVSEYRINNRVVTAQQYNDALEAENILIKARNFLVFQGDVESIASQSPKDLTRLIEQISGSLESKADYERLKAEQEEAAEHLNFQLNRRRGINSEIKQYQEQKREAETYARKAEERDQAIITHILWKLFHFQRLIVESSAEIQKYQDELKEFRRGVEKYEKNLEDAKVEHARVGRDVSRAEKGIKMKEKEIEETTNSLVPINEKIEITGKKVAKYASRVDEVSKEALSQAKTVKQLEKDLKVVEKAQSQWENEWKQTIAVKGIQLTDADLQEYSRLKEEVSKRSSSTQLKLDNLKRQRKADAEAVNNMKSNLESVEWQAKNLQTDMDHILERKAAIAATIKSTSKEIDATKKELNSLTSERLRVAQMRTELEEKLQVTLKKLLEADDGRQQSEKEQRTKEMIATLKRIFPGVKGRVSELCQPKQKKYAEAVSTVLGRHFDAIVVDNEKTAKECIQHLRDQRAGQATFIPLETIQVKALNSNLKGMHRAMRPAIETVDFDSSVSRAITYACGNSIVCDDLATAKYLCYEKGVEAKAVTLDGTVIHKGGLMTGGRGPGQRNAKRWEDTEIANLNKLKDKLMADLANLPKAHRRGSEEESLQGQLTGLEQRLAYSRDELSALEKNLESKSSEVDFAKRQIKSVQPKYREKSALLESLDQSIEEIQSSVTEVEDKVYRDFCKRLGYKNIQEYDAQQGSLQEEAAEKKLQFTTQKTKIENQLSFEKQRLQATEMRIDSLKTQSQKDEAMIAELEAERGSIQERLDELNDELASLNETLQDQQNLFSESSEKLAQQRRELQRRSKNVEATLKTISGLEADVQRHSSGRYTLIRRCKLEDINIPLTADSEPLDKLPIDELVQPDPDAMEIDEDSNNPVPQNHVVQDFGIEVDFLSLGDSLKEESDDKLEEELQERVRSLNNELDKMAPNMRAIERLEGVESKLRTIEKDFEDSRKRARKAKDDFEEVMQRRSELFNKAFTHISEQIEPIYRDLTRTESYPMGGKAYLDIEDSEEPYLDGIKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNANVSRIANYIRDHAAPGMQFIVISLKTGLFQVSEALVGIYRDQAANSSKALTLDVSLIVPFDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S0</accession>
    <name>D4D3S0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000089">
        <property type="protein sequence ID" value="EFE43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024111.1">
        <property type="nucleotide sequence ID" value="XM_003024065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S0"/>
    <dbReference type="GeneID" id="9577109"/>
    <dbReference type="KEGG" id="tve:TRV_01732"/>
    <dbReference type="HOGENOM" id="CLU_051208_2_1_1"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="317" mass="35305" checksum="9F5D7110037C3C81" modified="2010-05-18" version="1">MFSPSYFRSVLGATKRIKVGLVFSANVMEAQWLTAAFQQVTNLFRPLSTSSSSSSDIPPEILSAIQKGNGESSSGIPEIKNGKIVCSGFNNTAPNICAFRSIFQTHLSPADLTSSPCRNDRLEVYKEKFRLPKAIQAAYMKPLKRKPEYGLPVCNLQLRSYSARHVEFFADFALRAAYYLNIPASGPVPLPRIVERWTVIRSPFVHKKSKENFERITCRRLIQLQDGHPEAVQAWLAFLRKHAFHGVGMKANVFEHASLDVGKEMDTAAKSLEKALDEELAHFGAKKGAEFPESLASMLERETQTRTAAPLTEGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3S6</accession>
    <name>D4D3S6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000090">
        <property type="protein sequence ID" value="EFE43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025849.1">
        <property type="nucleotide sequence ID" value="XM_003025803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3S6"/>
    <dbReference type="GeneID" id="9577100"/>
    <dbReference type="KEGG" id="tve:TRV_01738"/>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="285" mass="32384" checksum="8CC93B6959426922" modified="2010-05-18" version="1">MGKRKQVKDVEMKDGAAEDSSDEDLDIINVDFEWFDPQPAVDFHGLKVLLRQLFDSDSQLFDLSALSDLILSQPLLGSTVKVDGNETDPYAFLTVLNLHQHKDVPVIKTLTDYIRTKSSSPDCSTLNQLLSQPEIPQIGLILTERLINVPAQVVPPMYTMLLEEIAWALEEKEPYNFTHYLIISKTYQEVESKLDQEDDRPQKKKKKAGNEGSETFYFHPEDEVLHKHALCYTGYNYTHETEGQSDSKRAFQELGIHPQGHMILIEASKFEAAVANLKEFLNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3X2</accession>
    <name>D4D3X2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024018.1">
        <property type="nucleotide sequence ID" value="XM_003023972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3X2"/>
    <dbReference type="GeneID" id="9582710"/>
    <dbReference type="KEGG" id="tve:TRV_01785"/>
    <dbReference type="HOGENOM" id="CLU_028200_12_8_1"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="29814" checksum="97D98AF18DDA05AA" modified="2010-05-18" version="1">MIVAPALWATKSAVLVLYIRIFSSVRWISRVSYGLIVLTFLVYGINIILATVYCLPRNGAPWDATAFARCAEPVTLAIFIGSFTVLADFIIFLLPFPIIRKLQMAQAKKVGLAIVFLVGFTTVIMSITSLGFRIQLFLGEDPVWNGLCISLTTFAELFGTVIVSCAPAIYSFWLNIVQPSTVYSTLRSRLLISKTKSNPDNQFADEERFELPSKLRNGHDSWPGDSVDGLGGKTGPFTRIYSSSSSSIPMKNAISKAIHISQSQAGPDTPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4B5</accession>
    <name>D4D4B5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023880.1">
        <property type="nucleotide sequence ID" value="XM_003023834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4B5"/>
    <dbReference type="GeneID" id="9582512"/>
    <dbReference type="KEGG" id="tve:TRV_01930"/>
    <dbReference type="HOGENOM" id="CLU_627297_0_0_1"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="437" mass="49312" checksum="D79B194E9A33DC64" modified="2010-05-18" version="1">MEQDNLRIPPLALPAAQQTPAPAPAGSPDESTEMHTASPASPASSSLQPSPLLPPNRAYPSLNNNLYIPHHASIPDPSLFSPSSPLQQHPEDRSYDAEKRSRRHHKHQKSRHERDEKYLRNPSFPIPEQVAEMPFHLGKKRARAAAAEAEERAKAQEKRELDEKARRDREAKENREELARRFPFTRTREAVTQARVDELHTKRLEAEAELFDEITEKSGSFSKRIEDTCGNLVNDASVIRGTIYSLQRLSNTALAQHREFLYRTTGVMRNAERHVHNINKFERQLQSIALLEARLKATEEASKKLDARLDVTRQRIHAWDREEDKWQAKINRRLRILGAAIVFLFVAWVGMKVMGKMYPDYSIFGSKANTTLHGNSSECCVETLDNAKNAMTTGTAIGVATGTPTGTPTTGRARSAYKTPLDLDALEEPLQRIIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4D7</accession>
    <name>D4D4D7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023902.1">
        <property type="nucleotide sequence ID" value="XM_003023856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4D7"/>
    <dbReference type="GeneID" id="9582502"/>
    <dbReference type="KEGG" id="tve:TRV_01952"/>
    <dbReference type="HOGENOM" id="CLU_037142_0_0_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="110"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="30953" checksum="62F9E4313F58F75D" modified="2010-05-18" version="1">MPPTDEITEDEEMFEDEYSQPPFEPFKDLCKRRFLWYYETYKNTMAEAETKCPVGSRFQRMQFEFTGNTMDGHFNYTELTKRLDAIKNAIMKETDSWAEMGRKAIKNETRIAVNLQRQYEQIVEDLKNKRHFTIDISLDEGNPLVWMLTYFGRPMTHLDGGIFRIKIALSPNFPDEQPRVIVQTPLFHHRISKDGILCYFPKKLEDMKAHVEAIVEALEDESPPYDPRATVNPECSKLFWGSAEDKKKYNRMLRRSVQRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q5</accession>
    <name>D4D4Q5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023782.1">
        <property type="nucleotide sequence ID" value="XM_003023736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q5"/>
    <dbReference type="GeneID" id="9582361"/>
    <dbReference type="KEGG" id="tve:TRV_02071"/>
    <dbReference type="HOGENOM" id="CLU_601240_0_0_1"/>
    <dbReference type="OrthoDB" id="4203839at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="543" mass="59926" checksum="6816513C52145E23" modified="2010-05-18" version="1">MSAYRGMPVTGPSGTQYYHGAQPIHPQAGLLQPPLALQPSGSGYTQQPRPQLQSQTQAQPQGQSEIQQADIDAFEAEIEYLKEQLEHSELQRECIQNKLNTALAQERHDHDMIEGLQARIRELEEMLQRHGIQGDSRSASMALVPVSSPDTEGYSGSGSGNGNGNGNGSGTRRMSMQGHPELSPTTRYQNVFGQPPPPFNLPGAAGAAAASGTARGNINQAGAGSQSHFIPTSSNANSTGGTGTGTTGVSRGTSSSPDEQIASFVSMVNMRPQQVIHTRDPPYNSSDFANRLVGLWTASKCFAMKYTNTNFMYDEKVMSAELRSFLSHASSNATELLGNVSTRFLMVSKMINWFITRTVLKTSVVNGFDPTVDSEIQQMTTHLHPGTPTTVKNAMIQGIGHHILLLRNRPLFDNFFNKRTHENTQELFHLLSPFIFSRDPSVWRDLVEIMIDAHSLALIMHSGPYEFKFLHPLTHHHFDPTYMTDHNAGTEEDWQMQESKRKYTIKLSITPVPLFKNVVTHPNAAVQVLHLGDMLLNSEPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4T6</accession>
    <name>D4D4T6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000112">
        <property type="protein sequence ID" value="EFE43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023760.1">
        <property type="nucleotide sequence ID" value="XM_003023714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4T6"/>
    <dbReference type="GeneID" id="9582335"/>
    <dbReference type="KEGG" id="tve:TRV_02103"/>
    <dbReference type="HOGENOM" id="CLU_1518949_0_0_1"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="177" mass="20116" checksum="A8A27BC02CFBE72A" modified="2010-05-18" version="1">MLINGIRNRLFVPPLNPIIKQTTSDERELRPASKIKPENRHVAWNSWNWDTIRRHQIVLGALWNTAATSPTIPGEEHLVQRKRVIFGNMKLADSTRRTDGIPFTKPGVPFTFKDPVNKRDEGRLFVFTSDGKLLEIEEMKVEGDRMAPAYRAALKAKLVDPVAARTSMHSVFHGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D523</accession>
    <name>D4D523_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023684.1">
        <property type="nucleotide sequence ID" value="XM_003023638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D523"/>
    <dbReference type="GeneID" id="9582231"/>
    <dbReference type="KEGG" id="tve:TRV_02192"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055253" description="Glutamate carboxypeptidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="161"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="347"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="7">
        <location>
            <begin position="601"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="79208" checksum="5899043EC522DBB3" modified="2010-05-18" version="1">MIVKSLSLLALAAATVEGCVRERDVGSVDILSVLSKRGHGHPHLPHLSKYESMLINSFDNTTVDSWAYYYTHGIHIAGTNQSMAQWTADKWTEFGIPSSLVSYDVYLNYPVSHSLSLTHPDGTTWEASLVEDVLKEDDTTSYPDRIPTFHGYSASGEATAEYVYVGRGQKVDFERLIQLGVDLKGKIAIARYGGPFRGLKVKNAQDQGMIGCIIFTDPADDGNVTVANGLKAYPNGPARNPSAVQRGSVQFLSMFPGDPTTPGYPSRPDSPRKDKSPVVPKIPSIPISQLDAQPILAALDGHGTPGKEVNRTRWVGALNATYATGPAPGAKLSMSNVMHDTYTPIWNSIGIINGTEQDEVVIIGNHRDAWIIGGAGDPNSGSSIMVELAKAFGKLQKAGWKPKRTIVMCSWDAEEYGLVGSTEWVEEYLPWLKASTVAYLNIDVAVSGPVPDLSATPELHKLALESMKKVIWPYKGRQDTTMYDVWNTASGGEVGVLGSGSDYTAFVHNGIASLDTGAGGDGNTDPVYHYHSNYDSYHWMATYGDPGFHTHVAMGQFLGLLGYHLATDDIIPFDVTNYGVQMTKYLDVLKKYIAASKFPDLDVSKIESAICSFNVSANAVAKLQKKAEHNVHDQQLRKHLNTIYRDFGRGFVSQGGLPDREFYRHMLYAPGLDTGYAPTTFPGVTESLDAGNRTRAVEYIERASNAIYVAAGILSSCHDCNQFVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D598</accession>
    <name>D4D598_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Intracellular protein transport protein (UsoA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023521.1">
        <property type="nucleotide sequence ID" value="XM_003023475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D598"/>
    <dbReference type="GeneID" id="9576993"/>
    <dbReference type="KEGG" id="tve:TRV_02268"/>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="327"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="805"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="665"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="103880" checksum="2F1BDF43A5CD484F" modified="2010-05-18" version="1">MFRILESQAPARQTATDTINTLSSRLQSSTLLEDRRAAILGLRSFAKGYPASVASEALRPLITSLRNDVEDVDTIKLVLETLLMLFSPEENSNGQRQDNITILLDLLDTKEFYSRLYSLQLISQISAARPERTQECILTAPLGISRIAAVLDDSREPARNEALLLLIALTVSSAELQKVVAFENAFERIFSLIEAEGSLKHGSRTLEDCLALLANLLQLNPSNQSFFRETGCVRKLVLLLEDAMKDRKPEEEFPVWMLEQRNKNIWGILAIIQLFLVKRGISTPVNQMAFWQSGAMQQLLRAAFNEEFDVSLKSKALLAASDLICSNATLQEKFSDMEVTITSTPVDQKLVNGNAPARSVERLNVLEALLRLTLQQGPINMLDARLASCDCIQAFFTNHSGIKLHFLNRAISGHTGGGDEIPNILSILIRPLDFDTTKDPYQLWLASVLLFHLIYEDSEAKAAAMKVTEGDAESGEEVVTCVQAIAGNLITGIQRNDDERISVGYLTLLCGWLFEDPDVVNDFLGEGSSIQSLIQEAKQEGSPESLLPGLCAVLLGIIYEFSTKDSPIPRSTLHQLLISRLGREQYIDKITKLREHPLVRDFEVLPQTVQGQHDSGLPDIFFKKTFVDFLKDDFSRLIRAIDRDPGMEVPVLANGIPKGISRELVDNLRAQAEERAQAIQNLESEMLDLQRKLDQEHMDHKRTKDSTNHELHRLNQANESMKKTHQAELSRLEEQHTLAKSELVRNHGEQLHALDNQLKQTASEHERRTTELRDMHESEVTELKQMVQKLEASLDKANKDHILDLQTAHEEYSTNLSNLEAKNQRAEEKARQAEEHNKMLEKSLKEARERAEKLQKASEESEAARKSAQNELEDLLIVFSDLEAKRKADKKRLEALGEEVSDIDEYEDEDEDDEDEDEGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5E1</accession>
    <name>D4D5E1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoamyl alcohol oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023564.1">
        <property type="nucleotide sequence ID" value="XM_003023518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5E1"/>
    <dbReference type="GeneID" id="9577036"/>
    <dbReference type="KEGG" id="tve:TRV_02311"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055342" evidence="5">
        <location>
            <begin position="24"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="56107" checksum="AE737FB36D1F13C1" modified="2010-05-18" version="1">MRFFRQQLAVGLGLAAFSVDTLATQSQPSAISDHCVQACKALTSKLADQVSLPNTTVYDEEKTQFWSAQQSDTSPTCFFRPKNSRDVAAAIKICRHTGCPFAAKSGGHAAMAGASNIAGGLTIDFSSIKSIIVGKDRRTVSLGTGNTWLNVYSQLQKEDLVVVGGRVADIGVGGLTLGGGISFFSNLYGWAADNVRSFEVVTASGDIVHASSHQHTDLYWALRGGGNNFGLVTKFEVFSYPLRRGEMWGGNLVYPGAQNASMFRHLAEYTKHGAEQDPKSALIVNVVYVQQFDQYICVAQVEYSEPMKDNNTHPAVFDGIFAEPGRVMDTVKSSTLAQIATDFNDANPNGLRESYWTATIEADAELLSDLLELWVKAIDPLRKNVKGYLPVYSLEPIGTPMLKPMARRGGNALGLDDTKPIIIMNPSARWEYAEDDKVVIDAYVGWLEKAKAKAEERGLWNDFVYMNYASVKQDPIRSYGKANIERLRKVAKKYDPEGIFQRLEPGYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5J7</accession>
    <name>D4D5J7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_02369</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023475.1">
        <property type="nucleotide sequence ID" value="XM_003023429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5J7"/>
    <dbReference type="GeneID" id="9583495"/>
    <dbReference type="KEGG" id="tve:TRV_02369"/>
    <dbReference type="HOGENOM" id="CLU_009667_4_1_1"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="551" mass="60909" checksum="4B96C3F73528FAD0" modified="2010-05-18" version="1">MSGKLLTSENVGPAGLCAAIQLKKLANEAGNEDFRVLLLEKAGEIGDHIVSGNVLQPTAINELLPDWLAEDNPNRFEHTTPVTTDKMRFLTEKYAIPIPAPPQMNNHGNYILSLSQLCKWLGERAEELGVEVYPGFAASEVLYNADGSVKGVATNDVGIGRNGKPKESFERGMEFHARVTLLGEGCHGSLTKKVMKKFDLRRDCQPQTYGIGIKEVWEVQPEKFRKGEVTHTMGYPLPRDTYGGSFMYHFGDNMVSVGLTVGLDYPNPWLSPYNEFQKLKQHPLFRSVLEGGQCIAYAGRALIEGGFQSIPKCAFPGGALIGDSAGFMNVPKVKGTHTSMLSGMLAAKATYSALSGNSSDGTIFLYEYEDALRSSTIWSELKEVRNMRPSFNTSLGVYGGIMYSGLEAYILRGRVPWTLKHHSTDSAATKPASECKKIEYPKPDGEVTFDILTSVSRTGTNHEEDQPVHLQVADWEKHTADAWPKWQGVENRFCPAGVYEYIEDKDKPHGVRFQINAQNCIHCKTCDIKVPTQDINWQTPQGGEGPKYSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M9</accession>
    <name>D4D5M9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023465.1">
        <property type="nucleotide sequence ID" value="XM_003023419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M9"/>
    <dbReference type="GeneID" id="9583483"/>
    <dbReference type="KEGG" id="tve:TRV_02402"/>
    <dbReference type="HOGENOM" id="CLU_001482_2_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055265" description="chitinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="434"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="13">
        <location>
            <begin position="495"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="580"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="562"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE42847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="852" mass="92595" checksum="D1FEC370C0E43447" modified="2010-05-18" version="1">MGRFSFLTLFLFLTVKAASWNHTQPGIETYPTVFKATGFKSTEHQFGLGTVPITQLGPGEIDDPWISRLIDGCPQPCSVVGSDPANWTLLYTQPALTDCRLPLLFDLNVQSTETRYPIIRACTASSEKPIPKRAASSIPVTNHSNNTTKNVTAETEDLIPNTMTPVSSSSICGAKGVIIDVLFTINPSILTPGDDTASAVSILSSHLANSASCGEKILLAKLGSVVVGLYIGADIQITAAAKTINKFGVMSQKLTSWPTLLSVVLKKGAQAIQTCNTSIREARTVGLFAVEKTEDLYMVQSALKQWANGGCLYFPRSRVLATIAELGVLTAGEPNNLTDLDTRPIWRHTRPMLPHAKSGFHSLAIRADCRAIQVGAGDSCTALSVRCGIRGSDFLKLNPVTNLCSTLMPKQWVCCSGGTLPDRRPKPQPDGTCATHTVVVGDGCFAIADNYGITVNDIDKLNKGTWGWAGCNRLQPGQVICLSKGNTPMPAEIAGVDCGPQKPGTKKPSGKFDGRDLAKLNPCPLNACCSGWGFCGITAEFCTESPADTGAPGSFKHGTNGCISNCGTKIVGNKTPGGSFARVGYFQAYNFHRDCLYLDARKIEENFKDLTHVHFAFAGLTEDFNINIGDNIREQFDLFNSMKAPFKKILSVGGWAESTEPGTYSRYREAVSPKNRYIFAQNVVKFLDSHNLDGIDFDWEYPGATDQGIPASNPYDAENYYRFLTQLRVLLGTAPGSRSLSIAIPASYWYLKPFPVRAISVVVDYFIYMTYDLHGQWETYSALAMITKAGVVPEKVFVVSTKSMKATDLNTAVANAELQKILEYTDKGEKGFEAKKWYDAETDSDIMTWLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5W1</accession>
    <name>D4D5W1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023382.1">
        <property type="nucleotide sequence ID" value="XM_003023336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5W1"/>
    <dbReference type="ESTHER" id="trivh-d4d5w1">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="9583402"/>
    <dbReference type="KEGG" id="tve:TRV_02484"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="561" mass="62028" checksum="4617D29413C9A403" modified="2010-05-18" version="1">MGLGRVKSRAKVVWEIFPQPVTLRYGVVTEEWNIKCGLLPCLQNFGCPGDFSSVASNLPSDWESFILPHSFVFLHYYPFIRSLSSFHSFTFVLFIIFDYQDNGSRLRMVVFSTLWFGLLFFVVTTQALPSQFNFHGPAPLPSEDPFYQPPQGYECFEPGTILKHRKVPNPIVTLGKIPVQLSGAYHVMYRTSDNFGNATVAVTTILIPKKPDYNKLLSFQVAEDASSPNCGISYAIQRDHQAKPKHGTIITRVELFLIIAALKNGWVVTAPDFEGLEGSWLANYRAGYAVLDGIRAALASNCFTGIAQDAVVTMWGYSGGSLAAGFAAELQPCYAPELKIAGAALGGTVPNITTVVHAANKSMWAGLLPAGIYGWSRDYPLVETTISVMLRPERRKDFLKVADQCFAANLVDFAFHDILAYFKDPNIFDRPEYVKIVTENSMGKSIPQIPLFVYKSKEDEVSPVEDTNDLIKYYCDNGANIHYNRDLKAGHLLLALSGAPSALNWLADRFEGKSVSTGCRVTEELMSLTDPQAYRVLGLALIGELLVLLGKIILGPTSLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D645</accession>
    <name>D4D645_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023294.1">
        <property type="nucleotide sequence ID" value="XM_003023248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D645"/>
    <dbReference type="GeneID" id="9583314"/>
    <dbReference type="KEGG" id="tve:TRV_02568"/>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="130"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="805"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="977" mass="106134" checksum="25E798CC55C4230C" modified="2010-05-18" version="1">MSLSNALFASLAGTRNARKRYSARGFYLVILTVLAVALGSLLVSRGKSAQGGLFMPEAARKTRRSLEPGTASWAIQDNGKECRLVHRAKHQCAFIRDNCEDENIGLIPYLEFYYCGLSSAKPVGFFLLAAWLAMLFSTVGIAASDFLCVNLSTIANILGMSESLTGVTFLAFGNGSPDVFSTFAAMSSNSGSLAIGELIGAAGFITAVVAGSMALTRPFRVARRSFVRDILFFAIAAGFTMGFVADGKLHSWECASMIGFYIFYVIIVVTWHWYMGRQRQRLERDIAARAHFHIPQNQELEINEVPENDDPIAGGENRPLLGATNDDFGSLERADIPTLRIEDEGEGEERDRQQLAELHENMRVNRPQANQRMLSSGGIRPSLVGALEFRSVLSSLEKSRSLQSGRIHLRSYSDDPFSPANPTAARPRASTTQRPEFYSYHDNDRFGQHGLSTSAQPRILSHSLDNPPGAHLEHQANLLCASPTSSGYPSRSQSPAPSVDRSRSPSRLAPPRTVFQQPSYASGGPTPSIQSSISPQTTPPAHGRSSTPTSPGSSITPFPPYTDETGYTPHGPSSLRFQRSAQSLGSQYIRAQSVGTDIEVSGPRWWPHSFPIPKAIISALFPTLYNWGEKSLWDKFLGIAAAPSVFVLTVTLPVVETDSSEPEAISIPDQGAAVIVEHQVPSITVPSYRDDETAEANPQELARPSLNRLRQDSELPVHPPCEVLGKEESPVKQWNRWLLLLQLYTAPLFITITLWNSLRPEHDPHTLILPILLSLLLSSGFAIILLLASKGSRNQLPKPLRPFVAFLGFTVAIAWVSTLATEVVALLKLFGVVLNISDSLLGLTIFAVGNSLGDLVADVTIARLGYPVMALSACFGGPMLNILIGIGVGGLYMTLQPIQNMQSASITPAVSAALQPYPIEVSKTLIISAATLMLTLLGLLIVVPLNKWRMDRNVGFGLVSLWVISTVINVVLELVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D667</accession>
    <name>D4D667_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HLH transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023256.1">
        <property type="nucleotide sequence ID" value="XM_003023210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D667"/>
    <dbReference type="GeneID" id="9583289"/>
    <dbReference type="KEGG" id="tve:TRV_02590"/>
    <dbReference type="HOGENOM" id="CLU_021798_0_1_1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="39130" checksum="CB92D408F3F4F31C" modified="2010-05-18" version="1">MDKMDKAADDLYFALPPAAIQHHHHHQPQQQQQQQQQQQQQQQPQQQQQQQPETRRSKRQPEFSLPPPPTRTRKIIQVKPKRDEEADQQDAAPAATTKKKSSAATAAGRKIARRTAHSLIERRRRSKMNQEFATLKDMIPACRGHEMHKLAILQASIEYVNYLESCVRDLKAARRDDTPTSPCWQPSANIQMDSASSYSVSPDIHPSTANTSTMPSPAQSQGHQTASAGFDIITMVLPSPALRPTTTSTTASSASRTYSMSTTATSTNTSPLLVPTGGDDVAVQDDDVDMDREASAALLMLNTDRRHSSTSATTASATTSPTIWPHAHAQHTLTHTHTHARRKLGMSVHDLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6X0</accession>
    <name>D4D6X0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 chromatin remodeling complex (Ies1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023026.1">
        <property type="nucleotide sequence ID" value="XM_003022980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6X0"/>
    <dbReference type="GeneID" id="9583046"/>
    <dbReference type="KEGG" id="tve:TRV_02847"/>
    <dbReference type="HOGENOM" id="CLU_007606_1_0_1"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123018" checksum="E6994BA8A1BBEDB5" modified="2010-05-18" version="1">MASTNPPSRQGSPAAAPVPAPAAAAPAQPRPSASPSPAPEQAAAAASDGESRAEAQATSKPDTQAQAEEPSTAIMEAGTGAGDSPDDRGAFEPEKETHFDKPDGGYYAGSRKDFPLPACRYPLPRTSVKRLSEPEPGTKGGRQRHYTDDPNYPLQGFWTEAGTWEDWPPKGSSSDPEEKEKEEKEKEKEKEQDGHDKPKEADNARGQPNGKEKEKEKEREKGKKDKSSESKPTKGESTSAEKRDAKPDAHTSSATSAPASSRRQTNGTIGSVYSGNKIRHLKKDDGIPLWRKDIQHLFLRLVFEDTTPVFTRHSDGKSGLSFADIYIDAMAKSSKTSKVLKDKLTTDKPAAINMAMVCLLVNFGRMNTTLNFFPEMRAQLRTYHSIPSLQAHQDSSAYKQLQDAPRLKSILKGASEDVEQPNTLDKLRETPVPRTNPVNLIFVLAQYAPKVSEIHFHSPHDFFDLVMRATLSSKSRAKAFLWLMWFYLESDFSDEAALKNPFGPGTVGEGADGSPLKIPQLEDLTEEEADAENVDTQDEILYGEEKQKERKRILDDDEVVSRNKRVKKVPGRDKQSTFFTPLNQSRRPGDDDDDELLTPVQSLRSRNKRKRDSSTTRSGNAGRTRVVLKTKMDQAGDGLSPAPPGSGHPVLHQFAPGSPAPGQTSSSSRRPRPLTQHQLAIEQNRRQRVDYILAQRRAEEYSKARERREQGSQLLHAGQLLQCLPVDYDTDDDHSWGKGGLCLNPDAQQEDFGEAGSFYFSVLKKVARRLHRWDWQSIATEDKDIGPNGLMHEHALDLGDANANGGMGDEEEVEPSGPPTSSRSRGGRRDRRSNANNADKLSTPDPNRLAAPPSTGKRQYIRRKPLPERKPGDPPKRVRPSRSKAALAAKAAAKAEAEAQKALALKQDANATGTSVAGSELGLPSSPGRDVRMKEAGDNENENENDNEQEQEQEQEQEQEQEQEQEPEQDQDPDQDPDDEGLDDIDKDIIGDASAYGDDGDEDDAEGESRLSVSPLPDADADADADADPDQEPGSEVVAAPSVIPDDASVAAMADDKTLPASINGHDDEHEHLGSDDSTEEDVTATALAAADSPDTISYTEEPGHGPDQEQNIDEDGDEIMTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D3</accession>
    <name>D4D7D3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_03015</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022853.1">
        <property type="nucleotide sequence ID" value="XM_003022807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D3"/>
    <dbReference type="GeneID" id="9581577"/>
    <dbReference type="KEGG" id="tve:TRV_03015"/>
    <dbReference type="HOGENOM" id="CLU_025461_2_1_1"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="76"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="328"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="215"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="60422" checksum="FE944ECCAD939825" modified="2010-05-18" version="1">MRLEEESFGHFYIILRKDEEAEKKSRRDAELDWKRRETLYILYTQRRAMAYNSRTTQYRGGQQQQHRQQKKESETDAFLRLPDKVIAGCINDIGIPFTMADLLKPNPQQVQMVFEWFAELFMNTTRETVEPAMLAAAEDIAGDQADIFPPDTRNLMGFLVSLRKLMLQCGVHDFTFTDITRPTYDRIAKIFSYLINFVRFRESQTSAIDAHFNKSEDTKMRIETLYAENQELEQRLEEMKRQQKEMDGVVREKTSRNDELKTRLLELRRDQERVAETFERVKGEKARKQTLLEEKTEKLLKSRQECEKLRPYVSQSPESLQSALTELSDNLAHDKSQVDGMERRMRALQTSMNTFTVVNNEVQSSIKLLEDILVELQKEDDQESKGIKNREALAERGNTVRQVAHTEKLLQSQLARWQERIEALRKSSREKAEQAQARMEELHSVQKQLREERAEKQREMERRRIRIEQTEKKMADLKETIEDEIHRAHDEYLKMESHIKLYTTEIEKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L6</accession>
    <name>D4D7L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KAR9-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000160">
        <property type="protein sequence ID" value="EFE42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022765.1">
        <property type="nucleotide sequence ID" value="XM_003022719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L6"/>
    <dbReference type="GeneID" id="9581455"/>
    <dbReference type="KEGG" id="tve:TRV_03099"/>
    <dbReference type="HOGENOM" id="CLU_005577_1_0_1"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="133261" checksum="196A0177F3E81913" modified="2010-05-18" version="1">MPKCQEPKRHSVNRAKGKNGRVEAAAVAVVAVAGRVQFPGVASKCSRSEITNLLANFTNTRTRTQRTATTAPAPASATSRDIFAVSVQGLGRHGLSLLSRTSEPQSRETRRTPASATPAAGRDDVSMPPGVSGPGNRSGTAAADSRDPPASPSSAVDSIFLPKRASAARSAAQRIASWSPSTRDTPGVAPVFAAATTARATLDTATTNTEKDAATEHKDKGRQSIFRRLSPSLAARVKLLDGASSKSDTASARSQSKSPVGKIPASQLQELERQNVDLSIRVQRRGRAWSGGLSAPHREQDSGRTLSQTSPVEPEANDHAERDAVATATAAPTAAPVPVLVPAPVVDHRILPTVEEKDASTDTDIHLSTMGTAGMSHGATIDAADSDIPPPPPPKDTPPLGHSSTGSNASESYFNPLGLNRPDSIYSFSRASFSNQLSQLTSISLPQPAALEESIASISSAPAAVRALSGAADQIQKWTNKASEVLGGLEAEDDVEWAAAGGREGLDDVDKAVSKFECLVNVYVKAIEEVQVREDIAEVGSESLNNIVTQMEQTIQNWGKVGALLHGVKEQVELAMEWEELWNAVLGDVGLEIDNLSRMIFEMEEKRHKSVMVMEMDNEPTTGLDINELETIVEETPSNIPTNPRLNFASFMSSGTQTPGTANQQDESSLLALFARMQPLRASLDFLPMRLSMFQSRAKDIFPSACEELEDRRLRLEQGYKKLETDSEALRRELAEDRWVIVFRNAGKQAHKMCESVERSVLKLREAIEGGIQHNNPTALAKRAENFEAKKVHYGSAIERVLSIIQKGINDRLTVNGEIIRLLADLTARFDALQASVHAMDALLDELNSRQLRDSVSSILTLDSPAGRSIGTPGSSPASSVIISNGNTNGSTANINNHTMIQDTSRRSSVAGGGSTASRGTAAKLKRHSALPGPTSTGIGHTPRKPSIPRAVSTPKITTTNHSGRPASRTGLVDPLTVLTYSNYVPDGRPRWNATYNTKDLVVGHVYKPQNPPPASSSSSSNRNLPVPISSRSPRPSHNQSTYSFGLRSPLSRESSSSPAPGRPSSRLHRGVTDRGSLEPGTSHAHGTAPSPSPSPSPRPSVFDPPPYSKLRKQAAAAASSASSTITTATARPASRLMPPTPTRRAKTPVPSVPAPTPVSKLAASPKPALATAPRSRQSYAGVPSSRTSFMPTNDGPGAKKSAGPPPVVARPGTSLGHSSRRSSMLPLPRTGVAGRSGRESATGTRKDERPPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L9</accession>
    <name>D4D7L9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000160">
        <property type="protein sequence ID" value="EFE42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022768.1">
        <property type="nucleotide sequence ID" value="XM_003022722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L9"/>
    <dbReference type="GeneID" id="9581458"/>
    <dbReference type="KEGG" id="tve:TRV_03102"/>
    <dbReference type="HOGENOM" id="CLU_098702_0_0_1"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="182" mass="20564" checksum="23C4601F38E024C4" modified="2010-05-18" version="1">MGEIGEYWEENRAYKKRKLERRKNNPPKQRCFDWMITSGISYAKNRSSFKTYRHIRPVTLASGTGARVIGVGSVELKVPRSPDNPEVNTLILDVVLHIPGAICNGFSPQMLGGSTSFGDPLQGYDDDEQPSYYATTFCGLWRLVLDGNPEGETQLAEARRNGTKLWLSVYINEEDEERIFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7W9</accession>
    <name>D4D7W9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022682.1">
        <property type="nucleotide sequence ID" value="XM_003022636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7W9"/>
    <dbReference type="GeneID" id="9581341"/>
    <dbReference type="KEGG" id="tve:TRV_03203"/>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="366"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="588" mass="64126" checksum="AEE088F386726F20" modified="2010-05-18" version="1">MHRLALRAGRSRKPSILRLAPRSFATVRQPENKDPVELDQITTLSNGLRVATESLPGPFAGVGVYIDAGSRYENNELRGVSHIVDRLAFKSTSKRNADQMLESLESLGGNIQCASSRESLMYQSASFNSTVPTTLGLLAETIRDPLITEDEVSQQLAVAEYEITELWAKPEMILPELVNMAAYKDNTLGNPLLCPRERLGQITKVTVDKYRTAFFNPNKMVVAFAGVSHTDAVRMTEQYFGDMKNQRSPLLAQFGSETSSTHGEEEVPTFPAFSPSSTTPTESPDSSAPHSPSLTPPSSPSSPGLLSRVPFFKNLSTSAPNHATVSPLNPSLLQTDLIDVSRPSYYTGGFMSLPRIPPPANPAMPRLSHIHLAFEALPISSPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCMAFNLSYTDSGLFGISASCVPNSIANMLEVMCRELQALTLDSGYSGLQIQEVNRAKNQLRSSLLMNLESRMVELEDLGRQVQVHGRKIGVQEMCKKIEALTVDDLRRVAKQVFGGLVQNRGQGTGRPTVVIQEGEMEGTKLAPLQWTEIQQRIAKWGLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8G4</accession>
    <name>D4D8G4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin containing polyamine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022450.1">
        <property type="nucleotide sequence ID" value="XM_003022404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8G4"/>
    <dbReference type="GeneID" id="9580997"/>
    <dbReference type="KEGG" id="tve:TRV_03400"/>
    <dbReference type="HOGENOM" id="CLU_004498_6_0_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="460" mass="51796" checksum="0AD023D048251C4E" modified="2010-05-18" version="1">MGRQNLLAERRKSQSYFVIVEYQDRIGGRLHNVKFGKKKDGSPYTVEAGANWAKKYKLRALATDYDNKTTYDKTGKNDFSKIIANAQAAMEKVVTHAGSLLKNNIQDKTVRAALRFMGWNPAANNAHAQFADWFGSDFESSFTPEENSAVFSSVADNATFKHFSDDNLFVYDQRGYSTFIRGEAATFLQPNDPRLLLNTVVQVVNYTDNGVTVVTNDGGCVQADYAVATFSLGVLQRDVVQFYPPFPNWKKSAISSFEIGTYTKIFLQFDKAFWPNSQYLMYADPHERGYYPLFQPLDLPGALQGSGILVGTVVGKQARRVEAQTNQETQEEIMKVLRTMFGESIPDPTDIWYPRWNQEPWAYGSYSNWPPSTSLQAHQNLRANVGRLFFAGEATSQEFYGYLHGALFEGRAVGQMLATCIDDPVRCTDKNGQPRYPVLSGVTPYDLYNEENGWFVSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K5</accession>
    <name>D4D8K5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000179">
        <property type="protein sequence ID" value="EFE41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022439.1">
        <property type="nucleotide sequence ID" value="XM_003022393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K5"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="9580986"/>
    <dbReference type="KEGG" id="tve:TRV_03442"/>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027699420" description="GPI-anchor transamidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45074" checksum="29C1A02F43EA6FC0" modified="2010-05-18" version="1">MELRLFYPFLAALLAIFLASSVSSAAHTSNWAVLVSTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYNNADRALDLYGDNIEVDYRGYEVTVESFIRLLTDRLGDDVPQSKRLGSDAGSNVLVYMTGHGGDQFLKFQDSEEIGAWDLADAFGQMWEKKRYNELLFMIDTCQANTMYTHLYSPNIIATGSSEIDQSSYSHHADSDVGVAVIDRWTYYILEFLETQVTSANSKRTLGDLFDSYDESKIHSQPGVRWDLFPGGEAEGRLRTVMDFFGNVQEVEVEAGSSVNDTEHSVKEDLVAIAKLVEQWKEMEKEHMENIRGPSSVGQKKPTLPSETGSPIHKLAGPMKMRDADDWSKRVIGLSLLFGIGGVWFAGSLRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8N4</accession>
    <name>D4D8N4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022407.1">
        <property type="nucleotide sequence ID" value="XM_003022361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8N4"/>
    <dbReference type="GeneID" id="9580954"/>
    <dbReference type="KEGG" id="tve:TRV_03471"/>
    <dbReference type="HOGENOM" id="CLU_046577_0_0_1"/>
    <dbReference type="OrthoDB" id="4173925at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="420" mass="46985" checksum="729E308C5058842F" modified="2010-05-18" version="1">MEEYPALHQLNIPPSIPAFLKPRTRNAQRKMNALVIGLTGVLSFAPFLGDLFAASRKDVAVVRVTLGEFDLFKEGVKTDTIGGDMPNVALFDANGQRIGFKNGEKHGKVKSGQGYDITVEPFESDNRKDPEYVTISASSSDAICIAAVTVTGADQGKKMDKTWAWNGGFGFLCGNLAWYPSKKLTTASERSPCIWISNDGRFPMGFSIHIPDFSHEELLPQFKYKKETVCDSKPRQHFYKDINELQCPPVFKEFPKFDEETGYENITQVLVDGVTTCKPAIGEEVSDEDLSRLRKGIKNHSRIGGETWTYGIKRSHVTKRREWQPLGCDLKNAVVVSKGYTARAICEHPTSAGPDYGNREEGLFCDMCTKKLWPFCSVKATANCFDEEHHIIRGDHPGFKRGINGTSVHKNYEDIQVWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S3</accession>
    <name>D4D8S3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022300.1">
        <property type="nucleotide sequence ID" value="XM_003022254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S3"/>
    <dbReference type="GeneID" id="9576903"/>
    <dbReference type="KEGG" id="tve:TRV_03511"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22360" checksum="F8F70B44CEC661AC" modified="2010-05-18" version="1">MPPKPDPTEVKVIHLRATGGEVGAQSALAPKIGPLGLSPKKIGEDIAKATGDWMIFAFVAVQTGLINKQKGLRVTVKLVIQNRQATISVVPSASSLVIKALKEPPRDRKKEKNIKHSKSIPFDEIVEIARIMRPCSFAKELRGTVLEILGTAFSVGCQVDGRSPKDVSDDVKSGEIDGTTAVSALGFFYLYYYSERASHYSMGFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9F4</accession>
    <name>D4D9F4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022142.1">
        <property type="nucleotide sequence ID" value="XM_003022096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9F4"/>
    <dbReference type="GeneID" id="9579013"/>
    <dbReference type="KEGG" id="tve:TRV_03745"/>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="39826" checksum="488880C82849C6E1" modified="2010-05-18" version="1">MAPPEAHHLFHRPIADHSFSSDRGTLAVAKDNVVELYETAGNKYTLKEELKGHDKTVTSVDVAPKSGQIVTCSQDRNAYVWEQTGSGWKPTLVLLRINRAATFVRWSPSEQKFAVGSGARVVAVCYFEEENDWWISKHLKKPIRSTITTLAWHPNSVFLATGSTDSHCRVLSSYIKGIDQRPEPSVWGERVPFNTNCGEYLNDSAGWVHGCAFSPSGDALAFTCHDSSVTVVYPSAPDQPPRAMLNISTRLLPFMSLVWISENEIAAAGHDCQIYRLNGDEAGWKLAGSLEVKAATRGAVAEESALNKFRQMDLKGSTKDDSKLQSVHQNTISTLRVYSEDGGTVKKISSSGVDGRVVIWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9F6</accession>
    <name>D4D9F6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022144.1">
        <property type="nucleotide sequence ID" value="XM_003022098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9F6"/>
    <dbReference type="GeneID" id="9579015"/>
    <dbReference type="KEGG" id="tve:TRV_03747"/>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1242" mass="133925" checksum="3832881FB2AC1CC4" modified="2010-05-18" version="1">MSSGHNTGKEGDEMFLNSPSGHEQPIVSPLRVAKRGTPSPAPSSSSNPQPDRQGTAQPSVSPLPYPDDRRAQDQSWNQNNSSQQSDSRKPSQTTYSPASLSSPASSNADIPAALKPQDRRDPKQAQSSLAERRGAAAPKQLESPTAESPDKEGLFQRLPQRAAPQQPSSSTQNNNPSVVVNPYPEYHQQYWPPPTQSVTSSSNLQAPTSSINRIDSTASTSTTKAQRGSPPPPETPIVGPGQQPSSDIEARYAASGIAGAATLSSIHAHNHAAQQRAQQYSGIPGRSNPPTVQHAAVAPPRPWTPTEQPGTEPHGPPRIYQGDSDVTPVPVTEGPSSQVSRAPQPITTAVTAPTSTATTTNNHNHSNNNPQGQLEDDFQRLNMTASPPPAYSSVMGGQNMAYPQEKHGGPTAQYPPIAGSVAASGPPSVAGSQPSIQSHPAFANDSRQAHTGTPSQHNFQAGPSAFPSSSKQSEPSSAHPGPGPASPPPLPEGWIAHLDPNSGQYYYIHLPTQSTQWEFPKGPTPLNLNETPMSPGHSTFGGHGLTSPGLSFAKPLASPALSAFGQPLASPALSAFGQPMPSPGLPMTPGYEGSVMGMNSGFVGPPPASGVEMYKVAPTNGVYFGPYLRYTNMDMERGLWLGSILLVTDASQPPTIHIHKSTDLSPNPRQLQPARIASHQRWIFYKYSIDIQMDDNSSHKWTYAITSHLGCTRYEFLVAGRHETAWRVVATSGNDFALNINANERSRLGGVGYMWKDIMQKHVECGGFHAQLCLGGQINADRLWKEVPSLKQWLAISGKEARKTAPWTAALEEDVTHAYFHYYTSHFDQPHLREAFAQLPHISQVDDHDIFDGFGSYPDHMQFSNMFKNIGRLGIEMYLLFQHHTTLEVLRHVVDDSDLFTITGTGWHFIKYLGPAIAVVGPDCRSERSPHQVLAGPTYQGIFPKVATLPPSVQHCIWMVSVPLVYPRLESAEHFVQTVATGKKAVTGAYNMLGRVTSSVAGVVGAKSAVGSGFDSVKRAVGKSGLMGSVLSPFGEIDIFDELKDQWTHESKDLERTYLIRTLQGIAHQRSIRMTFLSGAVNCCGAGLVHDPSHPTDHKTMYQIISSAVVNAPPPSYILKLLHGNNKPLYIPTNGQRSVTAQVSDTKEDMMELFQTDVSGQPREHRKLMGRRNYVAIVGYDPDAVQAAYSGMQSPMYPPNNSATGSFPKLSLAVDFLVQGEGSFGNVVKFGPVIVPSLELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9N4</accession>
    <name>D4D9N4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9N4"/>
    <dbReference type="KEGG" id="tve:TRV_03827"/>
    <dbReference type="HOGENOM" id="CLU_3417321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="26" mass="3154" checksum="6DEE16127062F899" modified="2010-05-18" version="1">MKPAALKRRQTNKTNKKKKKKKKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9T7</accession>
    <name>D4D9T7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000199">
        <property type="protein sequence ID" value="EFE41368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021986.1">
        <property type="nucleotide sequence ID" value="XM_003021940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9T7"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="GeneID" id="9578870"/>
    <dbReference type="KEGG" id="tve:TRV_03880"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="27817" checksum="AAA5AF47EC72C540" modified="2010-05-18" version="1">MVANNQNSSPQGRIFQVEYAQEAVKQGSVVVGIVSKTHAVLAALKRNAEELSSYQKKVIAVDSHMGIAIAGLASDARVLSNFMKQQSLASKMTYGRPLQVERIVSRIGDRAQTNTQVYGKRPYGVGLLIAGVDEAGPHLFEFQPSGMTQEMVACAIGARSQMARTYLERNLDSFADCGREALINHALKALKESLSQDRELTIDNTTVGVTGIPSAATNGKIDTFKLYDGPDVTAFLESANEETASGETKPSEEMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAE9</accession>
    <name>D4DAE9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021765.1">
        <property type="nucleotide sequence ID" value="XM_003021719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAE9"/>
    <dbReference type="GeneID" id="9578645"/>
    <dbReference type="KEGG" id="tve:TRV_04096"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="31874" checksum="E1CD39255390C997" modified="2010-05-18" version="1">MLVSGSYDEAVFIWDVRSARIMRSLPAHSDPVAGVDFVRDGTLIVSCAGDGLIRIWDSASGQCLRTLVHEDNPPVASVKFSPNGKFILAWSLDGCVRLWDYVDGRCIKTYQGHTNEKYSMAGTFGLYGHRRPPASSKKSPKEQQANIEKEYAYAASGSEDGRIICWDVISKKTLLELTGHSDVVLGVDAFSPPTMDQKRLMASCGLDQTVRIWEEIEDTAEVRAEETALKDVQKEESPVDKAENEDASMNTGEDPAIKADDNEGSDMQEQTPLMEKASNDKDSDGDLVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAL5</accession>
    <name>D4DAL5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000212">
        <property type="protein sequence ID" value="EFE41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021724.1">
        <property type="nucleotide sequence ID" value="XM_003021678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAL5"/>
    <dbReference type="GeneID" id="9576809"/>
    <dbReference type="KEGG" id="tve:TRV_04163"/>
    <dbReference type="HOGENOM" id="CLU_496590_0_0_1"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="61130" checksum="1C4DB7A9AAA11D6C" modified="2010-05-18" version="1" fragment="single">RATQWRKSFSCPGLGPTLLAEVLNLPERLRDSQMASRRQLSRIGTPSNGQSHASLSKCALVSNCPPYPVDMPFQLNEGQSETFYATKSDKSSDSNENQTEQQLMNSHCPLQREGVSGYMDQAKTGSLSSRDIGIWVNSWRVNHSYASSPSSATISIQGPTTHDIKYQSTPAPSAPWSQCEISPMTIAIEQPPQTPPRENWQPTSTLNSTTGFRDDKTYPPFEWQMKSSPDILPLTASTVREVGRMCVDSEHLVSGYLMSPATAECPERTEVEFYPYYAQNTSCPSIPYVGSQHHPWTNIPYPTVTSIPTQYPSSPWDATNDSYSNDYGFYCGPSSPFSSAVSSTATPDLPLTTKNPETLVTAENNMYLDGADLESTSEGYSRASSNADTDADAQYTPTGGEDEQAKIRACRSYSQRNDERDAFLIECKLAGMSYKEIKAKGKFTVAESTLRGRFRSLTKRKELRVRKPGWQDSDLKLLCEAVKRFAEPQSVSLIGDELLPPKISWKQVGEYIWKKGGSYHFGNATCKKKWAELQRNHAYVQKVSLNQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS0</accession>
    <name>D4DAS0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021638.1">
        <property type="nucleotide sequence ID" value="XM_003021592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS0"/>
    <dbReference type="GeneID" id="9576754"/>
    <dbReference type="KEGG" id="tve:TRV_04218"/>
    <dbReference type="HOGENOM" id="CLU_2856137_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="65" mass="6808" checksum="60E9B0E7DFE8F2C7" modified="2010-05-18" version="1" fragment="single">SKSSPATFLQAASSVSPLGPFLRFLPLAHSSIIIHHILETAVAGYQKMGFPKDGTQEISVGEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV0</accession>
    <name>D4DAV0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 20">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 20">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TRV_04248</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 20">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 20"/>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021668.1">
        <property type="nucleotide sequence ID" value="XM_003021622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576751"/>
    <dbReference type="KEGG" id="tve:TRV_04248"/>
    <dbReference type="HOGENOM" id="CLU_001935_2_1_1"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
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        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 19 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 19 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 19 20" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="556"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="23">
        <location>
            <begin position="807"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1174"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1277"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1624"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1348"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1399"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1546"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1638"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1660"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1671"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="19">
        <location>
            <position position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023029"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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    </evidence>
    <evidence type="ECO:0000256" key="17">
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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            <dbReference type="ARBA" id="ARBA00053943"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
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            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1680" mass="187430" checksum="16379B27ED9B3C9F" modified="2010-05-18" version="1">MASESDFESDGFSSDFAPKPKAKAAPKKAAAAPKAKGAPKKLTQTTLKPKTTSKATSSKKTARPDPEDELDSVAEDADSDDADALDSTPPNASKKQKAAPKKAASKPLANVENGSFATETVEGGGSSEKYQKITQLEHILKRPDTYIGSVERTEKHMWVYNSTTELMEYREVSFVPGLYKIFDEILVNAADNKQNDPNMSEIRVTLDKEAGEISVWNNGRGIPVEIHKKEQTYIPELIFGHLLTSSNYNDMQEKVTGGRNGYGAKLCNIFSNEFTVETADSKQKKKFKLTWTNNMSTMGKAKITECKGDDYTKVTFKPDFAKFGMDGMDDDFEALVKRRVYDMAGTCGTAVKLNGTRIPIKSFKKYMEMYTKAIKAERGEDPTSASDKNDIITESPDRRWEIGFTVSDGSFQQVSFVNSIATTSGGTHVNYISDQICNKLADALKKKNKTGATLKAAQIKNHIFLFVNSQIVNPAFTSQTKEQLTTRPSQFGSKCVVSDDFLKKVMKTRVMDDILHFAEKKADQILKKTDGNRRSRMNNPKLTDANKAGTKDGHHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASVDQISKNAEIQNIKNFIGLQHKKEYTDTRGLRYGHLMIMTDQDHDGSHIKGLLINYLQVAFPTLLKIPGFLIEFITPIVKVWKGDPKNPTHSKSFFTIPEYEEWKEAHAHDKKWQKKYYKGLGTSSTEDAQIYFQDLDRHLKQFHTLQDKEAELIELAFSKKKADERKEWLRQFKPGTYLDHSTDQITYTDFINKELILFSMADNIRSIPSVVDGLKPGQRKVLYTMFKRNVRKDIKVVELAGYVSGMTAYQHGDNSLHTTIVGLAQTFVGSNNINCLEPSGNFGSRLQGGSDSASARYIYTRLSPFARRLFHQADEPLLVNNVDDGKVIEPETYVPVVPLILINGADGIGTGWSTSIPNYNPEEVVDNLKRLMVGEELVPMKPWFRGFKGEVSGSGDRYKFSGIIKQTADNEVEITELPIRTWTQDFKDKLEEIIKAEKVPSFIKDYKDYNTHTNVHFIIQMEEKHMKKALEEGLEEKFKLVKQIATSNMVAFDAEGRITRYETPEDILRAFYAVRIKLYEKRKQYLLSELQTQLDKLSNQARFVQMIIDGELVISKKKKAVLIQELQEKGFKPFPKVVGTPEPGEAGDVEEEEDEEEETTTAAVSSDAYDYLLSMPLWSLTQERVDKLRRQIGDKEMEVDALIKLTKEDLWRKDLDEFISEWRFQLEDEDNRRKKIASRGRRLSSKVKTGSRATAAKKRKAGSGDDSDFDVPKGKKATVNRIQPKGGLLDFLSKAKPKPKATSRVDGADDSDDFEDEVMPKPKSRGAAKEAKAKPAPAPVSKGLSDADFLDIDSMGTDNPKREPSPVEKPKVVDDDSDIEMIPKPTTQRSARNKQQPKKYHGFSTSEDEEEDDFDVSAMVKGIDKKKPNTVSTGPTLFSEPSRPAGGNSKLPAKPAKETMEFDADETDYSKLIPQNSPRRSLLVKPKENKVFSDAEDDIEDEPKPVAKSTAKAKASSSSKSTSKPAAKTSTTSARGRPKKAVAAAPEKEKKALQLSPAAKVYASKKAKAKKIVDDMSDDDIDAMANDILDSEPEEAVKPSSRTRPARRAATTAKKPVYALDDDSSEEDGDAAVSSEDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAZ7</accession>
    <name>D4DAZ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021587.1">
        <property type="nucleotide sequence ID" value="XM_003021541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAZ7"/>
    <dbReference type="GeneID" id="9578548"/>
    <dbReference type="KEGG" id="tve:TRV_04296"/>
    <dbReference type="HOGENOM" id="CLU_020352_1_0_1"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="480" mass="53356" checksum="30EF6BA3EB397A02" modified="2010-05-18" version="1">MGAYKENRRHSHGSFVDIIMLEKPALAMGRVILSVNAGSSSVKVNVYHLKNPPVEVAAASVSGLTAPPSVFKYEHGSNHQKHETEEEIKSPQDAFKYILKRLLHDQELQVVSSNSDYAYVCHRVVHGGDLEEEVIIHEKTFNMKRRLIISRRCKTWRRCRHNTSALEIIKTCLQEVPSAKSVAYFDTTFHQCLPDYIKTYPIDPEVAKSKMLRKYGFHGISFSFILRSVSEFLHKPASETSLIALHLGSGASICAIQDGKSIETTLEMEPMADMHCIAGWASLRSPDFPAPQGAETSMQGPWCLADWFDSLVFHYTSEASKLSSSSTKEMHISKAEEILNKKSGWKALTGTTDFAKIGTDNPPTEMHKLAFDIFLDRIVGFIGNYFVKLGGKIDAIVFAGGIGERSALLRSCIAEKCRCIGISMDSEANSAGIPSEDQTVVDISEKSGQRPAALICQTDEAFEMAYRCMNKPPREEPAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB87</accession>
    <name>D4DB87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021539.1">
        <property type="nucleotide sequence ID" value="XM_003021493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB87"/>
    <dbReference type="GeneID" id="9578500"/>
    <dbReference type="KEGG" id="tve:TRV_04386"/>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="114"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="31606" checksum="A367584B2012F89B" modified="2010-05-18" version="1">MDGRKASELAQQPGCLGALVRFWRRSYGGDYSILIFLVFAWVMLTGVSKLQLFVHPFYQLFSLDNSSIQYPFAVVERVPVLWCIIYSGIFPLLAIGIWCALFRPGSHFVHVTLLGLIASLLVTIFITDIIKNAVGRPRPDLISRCKPEKGTPEHTLVDHTLESFLTGQFRAWRPRSGLARLLVSLSPLLGALMIAISRIADYRHDVYDVCSGSIIGLGTAYLVYRCYYPSLWSADCDTPYHPDDQGAMHGFQRVGDEEQAFQPQQVYNEQAYHMQPLGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBR5</accession>
    <name>D4DBR5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Haemolysin-III channel protein Izh2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021319.1">
        <property type="nucleotide sequence ID" value="XM_003021273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBR5"/>
    <dbReference type="GeneID" id="9578172"/>
    <dbReference type="KEGG" id="tve:TRV_04563"/>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35822" checksum="9BF86AAAF8FEFE55" modified="2010-05-18" version="1">MSLLQRRAVTTAAAAAVYKKEEAETSQHQQQTKTETEAEVLEQESWTATVHWDALPRWLQDNHHIHTGYRPASASFLRSFHSLTYVHNETVNIYTHLLPALLTLPTSFVLYQALSPRYHTATPADIVVFSCFFAGAAFCLGMSALYHTISNHSPWAAYIGNACDYLGIIGLITGSFIPSIYYGFYCTPQLQRLYWGMIVVLGAGCAAVATIPRFRKPALRPFRAAMFVALGLSAVFPVTHGVVVLGFSQARQQIGLDWLITQGALYIIGAAIYAARVPECLHPGKYDIIGHSHQIFHVLVVLAASAHLTGLLAAFDYRHSLATQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS2</accession>
    <name>D4DBS2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000229">
        <property type="protein sequence ID" value="EFE40708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021326.1">
        <property type="nucleotide sequence ID" value="XM_003021280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS2"/>
    <dbReference type="GeneID" id="9578170"/>
    <dbReference type="KEGG" id="tve:TRV_04570"/>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="855" mass="96747" checksum="677E78B98F7BF2FE" modified="2010-05-18" version="1">MASAPHVPEDQSRLLEEALGVVRQQSHMMRRCLETPGKLMDALKCGSTLVAELRTPTLGPKQYYELYMAVFDALRHLSDYLRESHPVNHLADLYELVQYAGNIVPRLYLMITVGTVYMSIPDAPVKEIMKDMMEMSRGVQHPIRGLFLRYYLSGQARDYLPMGSGDGPQGNLQDSTNFVLTNFVEMNKLWVRLQHQGHSREREKRTQERKELELLVGSNLVRLSQLVDLEAYKSAILQPLLEQVVQCRDVLAQEYLLEVITKVFPDEYHLHTLDSMLSAIARLNPHVDMKKIVIGLMDRLSTYATRGSEKSDDPEVRKKAEEEATVRLLENLQLSKETGEAPPASDEQKTADKEKGIVQSENGINQPGEGESGKDTKPESVEDQQETGEATFLPGNIKLYEIFYDQVLNLVKTRGIPIQDTIALLVSLTNLALADFHSAPAQSSILNLLLAPLQSYVSIFTALSLPNYIPFFAAQSYSTRRAVAGEVARNILRNRTLITSPENLDNVLQILRVLIREGMQQPAGYPGAQSQRRGGETEETIEEQGWLARIVHLVQGSDNDTQLKLLQALRTAYLDGNERIRYTTPSIITSSIKLARKFKAREHFDDNWHSQSSALFRFMHQCISGLYQRVNSGCADLALRLFVLCGQTADETGFEEVSYEFFAQAFTVYEDSISDSRAQFQAVCIISSALHGCRNFGRENYDTLITKAALHGSKLLKKPDQCRAVYLASHLWWVVESPQKEGDEPNIVYRDGKRVLECLQRALRVADACMDTAVSVELFIEILNRYVYYFDQQNETVTTKYLNGLIELIYSNLQSNQTEGVPSSSLESPRRHFERTLDYIKSRGWEGVVTEPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBW2</accession>
    <name>D4DBW2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021300.1">
        <property type="nucleotide sequence ID" value="XM_003021254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBW2"/>
    <dbReference type="GeneID" id="9578145"/>
    <dbReference type="KEGG" id="tve:TRV_04613"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="40377" checksum="C99A3998B0500228" modified="2010-05-18" version="1">MFNNGWWLKHRTPGVSRDEQQRRDRLSNKLYHDGGKIGEGQDEDDIVSISTFSISTKCWLAIRQNVTMAAEEVPLQNSELFDVSDCVAVVTGGGTGIGLMMAKALEANGAKVYILGRRLAVLEAAAKQATYGNIYPLQCDITSKDDLETAVERIASEDGFVNLVVNNAGISTPNLGPQRTRPNAKWSITDLRNYWFSKPSFEDYARVLEANTTAPLMVTFAFLELLDRGNRVRAEQAKANGGRSDYVRSQVIMVSSVGGFGRDNSAFIYGASKAGTTQMTKNLSTYLTPWKIRANVLAPGYFHTEMTQDFYKSTGGRLPATMTPEERFGDMQEISGTLLYMASKAGAYCNGSVMLSDGGYLAIHPSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE8</accession>
    <name>D4DCE8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021088.1">
        <property type="nucleotide sequence ID" value="XM_003021042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE8"/>
    <dbReference type="GeneID" id="9576740"/>
    <dbReference type="KEGG" id="tve:TRV_04801"/>
    <dbReference type="HOGENOM" id="CLU_073401_0_0_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="259"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="410" mass="45140" checksum="F432508B3ECA264A" modified="2010-05-18" version="1">MIPQCLIAMPQISPAAQRALSEAGSDIRTGLVSLMIPAALLYLALYALVKKKIGVFVMLDWMAIFAFAANGTLVVLECSVARSLQLFAASDLPTAYMILMMVTVAIGSMKALDFYARRKSPPKYTDPNPPSDSIIALLLFTELRYESFTPNYLRTAPAPAQLEADTTAEYVCYQKRDLKGGKQIFTTFGKRVASLQTPGRKTPHRFSEAFDLVIHVAFFLATQFLFPLSNPTVQAIQILLAIYVIWESLQLLLRYKTSPPLFGPVYTASSLASFWSETWHTAFASPCRSLAYDPLRRHLPAKYGVPESFAKGVGIIASFSLMGLFHAYSLAPVLPLDGILRIIAFFLLNGIGTVIETAIWGRNAHWGKALLAWTFEIVIASWTVEGLSLPKGLQNISWDSICNVGGVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCH4</accession>
    <name>D4DCH4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021077.1">
        <property type="nucleotide sequence ID" value="XM_003021031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCH4"/>
    <dbReference type="GeneID" id="9576724"/>
    <dbReference type="KEGG" id="tve:TRV_04829"/>
    <dbReference type="HOGENOM" id="CLU_2243092_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="105" mass="12108" checksum="53E9AF9E1DBE9315" modified="2010-05-18" version="1" fragment="single">EEEETGEGGKSDLIEGGPEKLRAREREREYSQAAMMTDGGGEERRRIERTASVRRRWNPEGDEDEDEVDVEEKTGEVKKKLKVEKSKSRKVEKLTSKAKNSKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD01</accession>
    <name>D4DD01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_05007</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020931.1">
        <property type="nucleotide sequence ID" value="XM_003020885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD01"/>
    <dbReference type="GeneID" id="9577764"/>
    <dbReference type="KEGG" id="tve:TRV_05007"/>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="574" mass="62667" checksum="3E616C6249EEC183" modified="2010-05-18" version="1">MAQALPTAMAMQAKLMALARSSSSAVFSLSNFDIARNIVFFVFVLRLLRRSFYTLRGHGIFGTLRNFYTYLRLVFYSLFLRAPGVRSQVDRQVKTALTKLEQKLAPQEPGMVKFVSLPKKGMSNDQVMAELEKLGGMKHTMWEDGKVSGAVYHGGDELLKLQTEAFGRFAVANPIHPDVFPGVRKMEAEVVAIVLSLFHAPDGSAGVTTSGGTESILMACLSARQKALAERRVTEPEMIIPETAHAAFTKACKYFGIKPHYVACPAPDYIVDVSAVRRLINPNTVLLVGSAPNFPHGLVDDIPALSRLAVTYKIPLHIDCCLGSFAIAFLKKAGFPSPYEDQGGFDFRQPGVTSISVDTHKYGFAPKGSSVVLYRHRSLRTYQYFVMPNWPGGVYASPSMAGSRPGALIAGCWASMMAVGESGYIDSCHQIVNAARKFERAVRQNPSLRSTLEIVGKPMVSVVGFASSTPEVDIYDVADAMTNMGWHLNALQSPPAMHVAFTLPTANAVDQLIDDLTTVVREEVLKAEQRRAAGVKVEKKRGDTSALYGVAGSIPDKSIVRRLAEGFLDTLYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD06</accession>
    <name>D4DD06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020874.1">
        <property type="nucleotide sequence ID" value="XM_003020828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD06"/>
    <dbReference type="GeneID" id="9577713"/>
    <dbReference type="KEGG" id="tve:TRV_05012"/>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="580" mass="62765" checksum="81C14C4AA9AB8C5C" modified="2010-05-18" version="1">MSFINVVRSDASTGNISNAYNWPSLCRFPQRIRFPAKLNKIISVSEQTQSRRREISRCPRSSHLQLLLSSIDLAPLGQLVCSLLSHPLIADSIARFIPSRQISTMASAAVLSRRLLLSKTAQHGLRESRNVLRLSDALSDIAYPPHTIISMPALSPTMTSGNIGAWNKKAGDTLSPGDVLVEIETDKAQMDFEFQDEGVLAKILKDAGEKDVAVGNPIAVMVEEGEDISPFESFSLEDAGGDKAPAADKSPKEAPKPEEAETKAAPTPTFEENKPEAREADTTGEKLQPSLDREPFVSPAAKALALEKGVAIKDVKGTGPGGRVTKEDVEKHQASAPAAGAAGPAYEDVPASSMRKVIASRLAQSIRENPHYFVSSTLSVTRLLKLRQALNESSEGRYKLSVNDFLIKACAVALKRVPTVNSRWIEQNGQVMIREHKTVDISVAVATPSGLITPIVKGVEGLGLSNISSQVKDLGKRAKENKLKPEEYNGGTFTISNMGMNPAIERFTAVINPPQSAILAVGTTRKVAVRSELEEGTEIEWDDQIVVTGSFDHKVIDGAIGAEFMRELKRVVENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD63</accession>
    <name>D4DD63_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020844.1">
        <property type="nucleotide sequence ID" value="XM_003020798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD63"/>
    <dbReference type="GeneID" id="9577583"/>
    <dbReference type="KEGG" id="tve:TRV_05070"/>
    <dbReference type="HOGENOM" id="CLU_100633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="25967" checksum="9182CD2055C96C28" modified="2010-05-18" version="1">MSPCMSHLHASIFDNSETQPIPILPPPPAPLSTGPSRARRQLAARLALQKQQALDAAAANNEGSEEDGKNPPLNFGNNRRFSTADHVLNTVFTKGESEDSSGNAMHDADTTGDLDHQSSSFSGFQDVSGYSDSSSDEDGSLPMESVERKFRLPVDAFDDDDEMGDMVGPSTSYSDEDDETIIQEALGYSTFLDSDHHGLDGSVYPEERELTPDSARGQDNSDGEDDGLVEILVPGKRSVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD74</accession>
    <name>D4DD74_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-containing alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020805.1">
        <property type="nucleotide sequence ID" value="XM_003020759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD74"/>
    <dbReference type="GeneID" id="9577556"/>
    <dbReference type="KEGG" id="tve:TRV_05081"/>
    <dbReference type="HOGENOM" id="CLU_1267717_0_0_1"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="218" mass="24326" checksum="7BA598F335702D14" modified="2010-05-18" version="1">MYLLMFAAIIYDAEITLHTPARLWLSSAVRNLRIGQQLSISQYAKEYIQVRAIDHAVELQYHPQAAEVPTKRLCRTAIREIFRLLPLCKKDPEDPKIRQELQIAAYSAFPPFYFTAPIGLSHAIGHVIGATYAIPHGITSCISLAKTIHFKATRNPEEAHQIAKILPYIGQACSGDNAKDANAVGDAIAKLVESLELKSTLTEVRKYPHNFLKIFTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDJ8</accession>
    <name>D4DDJ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020683.1">
        <property type="nucleotide sequence ID" value="XM_003020637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDJ8"/>
    <dbReference type="GeneID" id="9577382"/>
    <dbReference type="KEGG" id="tve:TRV_05209"/>
    <dbReference type="HOGENOM" id="CLU_013601_1_0_1"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="740" mass="80723" checksum="09042F3C71B61297" modified="2010-05-18" version="1">MAEKRKQPGPGKNRGGRPRKKRLEDAAEAAPSPKRQRRREPSATPSKKATATPAPSLPAELPAEESLPTKISENQTLPTLPRPQTQSSLLDYQSYADSGVISAALHRSRTRWLHDCLFEKYWTKPSKKKNQPQPTFQNPPKDSMTKLGPCTMVIEPHYFDIMLYAVRRPQSQQPNQQQQQKPMVQLQYTPPSNSGQFHEYNPRPPPVQVPPNRSPNTVPPPQPPRHPQQQYQHQQQPPLPPPPPAPPQQQQQQQPRQPPPLPHHPPHSQSQAPPPTTAPPPGPVHQPPTSQPHGHNIPQKPPNPPPGKPSTDPVIQLLANRAATNPDLRALMRIVADSQADQEQLRAFQAHIDEINAIIASRNSKDSQPNQSQAKPEPPTQMGAPPTSASAAQNRVHTPIASRNPAVAPGPVPYHPQNQHPHPPGPQYPPGPPGQQGPNSIKTKHTQKVPPPQNGYFRPQYSQPVSQPARMDIKNVVFEFILPAGSNNGPTGDRYLFPENMILDYFPGNTTVIASFLAIKKIGPPGSSTESDKKAPVKVRGKKAKLLQAAAASNSGDSPSKPPASQSESMKDTKGTDATATVENSKTSDAPETPDDNASSTSGTKPKAEESSVKEYYQPVTLRLHASNPRTLEPLGRVVKPPGEVRDYMNGVMDRIERADIEYLAFRLPQEHRRARGAAAGDETSKLAGPARGASKLNGTESESGVGTPRNGDRDDNGSKSAEVLQDHYDLPSGLVPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDQ3</accession>
    <name>D4DDQ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000269">
        <property type="protein sequence ID" value="EFE40015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020633.1">
        <property type="nucleotide sequence ID" value="XM_003020587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDQ3"/>
    <dbReference type="GeneID" id="9577337"/>
    <dbReference type="KEGG" id="tve:TRV_05265"/>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="553"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123086" checksum="0CE1C7FB80E553FC" modified="2010-05-18" version="1">MGATAPKQAPIYPVLAEQPVGQHITSIYKDRLRQFTATGQYQGHNLLDKFFYALNDDEKYVKLWVYSVPNLERPSFKDAVKNEFKPTRRGESFGPSWSTHWFKIQLTVPEDMRKYDHLEFHWNANNEGMVWTEDGRPLQGLSGGDRTEWIIPKDFRDGAPHIFYIEMACNGLFGNSDGDLIKPPSTNKYYRLDSAKIVAVNLQARALNYDFWQIGDAAREFPSDSWQAHKALIVGNAMMDAFIEGNGSQESIIKARKVAQEYIGTKVDSPDVYKTEGEPIVFATGHCHIDTCWLWPFAETKRKVARSWSTQCDLMERYPEFRFTCSSAQQFKWLEEGYPYAFDRVKSWVKKGSFQPIGGSWVEHDTNLPSGESLVRQFLYGQRYFESRFGKRCTTFWLPDTFGYSSQIPQLCRLAGMTRFFTQKLSWNNINNFPHTTFNWVALDGSQVICHMPPSETYTAEAHFGDVKRSITQHKSMDQDNTSLLVFGKGDGGGGPTFEHIEKLRRQRGMSDTVGLLPRVTIGGSVDDFFATLEKKAVEGTKFITWYGELYFELHRGTYTTQSNNKRNNRKGEFLLREVELLATLASLRSSSYKYPKKEIDNMWEPVLLCQFHDCLPGSAIRLCYDESDAFYAEVFRIGAKVRNEAMKELGFQSKESGSDGKLVALNTLPWPRSEIVRMNNPGVSSGSPQYALVSGGTGVMKVEPLSSTQSASLSVKEVDAGVFELRNDSLVVKVEKGVITSLFDVKAKREVIAKGGKANQFVIFDDKPLYWQAWDVEVYHLDSRKELPSTETKIAEQSPHRVSVVTETKISDKSWAKTTISLSAETKDSMPMVEMDCEVEWRETMKFLKVEFPVDVRNTEASYESQFGITRRPTHYNTTWDMAKFEVCCHKWADLSESGYGVSILNDSKYGFATAGNMMRLSLIRASKAPDDTADIGHHRIRYAILPHSGPLDYRTVRAGYNFNHPLAIESACGPETVQDFQAVRLVDATPALVLDTVKRGQDDEDVSNDDLPRRKGKSVIVRIFDSMGGRSTGVLETDLKVQKVFKCNLLEDDLEELPIEGSGPRRVNIVLRAFEVATYRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY7</accession>
    <name>D4DDY7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000279">
        <property type="protein sequence ID" value="EFE39934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020552.1">
        <property type="nucleotide sequence ID" value="XM_003020506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY7"/>
    <dbReference type="GeneID" id="9577251"/>
    <dbReference type="KEGG" id="tve:TRV_05351"/>
    <dbReference type="HOGENOM" id="CLU_1817206_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="142" mass="16179" checksum="45514797D125F714" modified="2010-05-18" version="1">MPLAPPQRDVREDRQLYPPGVEEGRRSKKQQRGRESPGLSLVAFWASRGALHVLTLLSLLFFFASYGNSTRATLLSVGSWRQCGSISMSTNYEAIVDPWPEFMEFNWTVAGAQQEEKEEEDEEEVEGPRRPIPIDLPRRCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE11</accession>
    <name>D4DE11_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000282">
        <property type="protein sequence ID" value="EFE39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020521.1">
        <property type="nucleotide sequence ID" value="XM_003020475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE11"/>
    <dbReference type="GeneID" id="9584261"/>
    <dbReference type="KEGG" id="tve:TRV_05375"/>
    <dbReference type="HOGENOM" id="CLU_312885_0_0_1"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="3">
        <location>
            <begin position="536"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="937" mass="105029" checksum="C17604CE57350620" modified="2010-05-18" version="1">MVGTKNDVLKVVGRVGVTRRTRASQRKTLQGKTPYEIPLLVLIYTHLMSSFLYFSQYTIGKQAISPNTLLSWAKSGSSSRSSTEKDGCELQAGQAEIIVPVLKDDLLEPYGQPPVWAEDRVVLGDALPWFHSVQGGCYYLDNICRGVLIDGDCGDRSYIDDEVVITRVKRGGSCKKTKEGRLVMSKDHDPNGPILRSLINSMRLEIPVGLILGSKNADCRTKVPYNFNVLDFFRITDIWFEQVGKHKGAQMRFEKINLATKSWWSPKGSPDPVPLEQRDSVTPAPDPICLSCSIGTAQVFAQGWMCLNPQCAELWKIEGSLPPSQLTFAPEFLTKRSEPKNAVLPPCSLVPDLLSTFSNDQTDVTGTRMAWKGIVCPQCRACIARIHWRRWECSTAGCGFQYSPPINHVSLRSVLPDLEMSPSGHRLPTVPKDISSMPMIQYMKNYRKDTFVLPGAGIVTHFAANRTVNSRPGGPDDLFSLMQREDLGLRRYPISPCVGKFPLSFFLLILSSSIPSLGTLKFAGTLTSHFAVNYGMPYKYIVSVDSRPFNTAPPVIISALERLKWATRHTVDANAFQMPNELLALGYFEDMSIGYHDDGESSLGPTIATLSLGAPATMLIRMKDEYYNGFRKRDGKDKVYLQHDPVLPGCANEEARAELARKFNAKEITSEQYLAARQALPTSRREAPPMCTMALNHGDLAVMHGPDLQKYYESIGRAIMTRSRNSNTMEMRLEDSDLLYPVFHRKFQKGAIEMVPTHHSWYTKEIIKICASFTGQSSYWPIFGRALTKWHALIEAVQDPPSPEIIGGEEEWEVEEILNSRITGRKKQLQYGVKWKTNCSHGHGAFNPLIPFDKSFLERTTASTHWKYATFREEPNNIGLQAQLSARAKYGVQNEWEPAQFHLRSGVNHAICLRDEANIRQGSSGTTSYRTLMFPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE53</accession>
    <name>D4DE53_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000284">
        <property type="protein sequence ID" value="EFE39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020487.1">
        <property type="nucleotide sequence ID" value="XM_003020441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE53"/>
    <dbReference type="GeneID" id="9584224"/>
    <dbReference type="KEGG" id="tve:TRV_05418"/>
    <dbReference type="HOGENOM" id="CLU_110797_1_0_1"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="150" mass="16214" checksum="DC5B91524E230D2B" modified="2010-05-18" version="1">MSEDIRHPAGEFQPSRPREEHPGGPKINMLNFYRNQHKPGVKASPADNVPESHAQAVPVGTAPRENLFQPRPNVEDMGGYDEGGASASSTLMGATSADVDKGMGKPLQGETKTEMRHGGEHHRKHPGSGLEGVGANTARTETEMNRLQRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEJ7</accession>
    <name>DPEP1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Putative dipeptidase TRV_05564</fullName>
            <ecNumber evidence="3">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">TRV_05564</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes a wide range of dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000298">
        <property type="protein sequence ID" value="EFE39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020339.1">
        <property type="nucleotide sequence ID" value="XM_003020293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEJ7"/>
    <dbReference type="SMR" id="D4DEJ7"/>
    <dbReference type="GeneID" id="9584076"/>
    <dbReference type="KEGG" id="tve:TRV_05564"/>
    <dbReference type="HOGENOM" id="CLU_031404_4_2_1"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0224">Dipeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411215" description="Putative dipeptidase TRV_05564">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10073"/>
        </source>
    </evidence>
    <sequence length="414" mass="45407" checksum="938DC330AB7F222A" modified="2010-05-18" version="1" precursor="true">MAALFVSLLALTSLVPVQGAATVPQTDYAKRAERVLKSAPLIDGHNDLLYAIRRSTNDQIYDGKLPFETSLKGHTDLPRMRKGRMGGQFWSVFIACPSDPNAPINTPKFATRDTLEQIDVARRLVDKYSKDLMYCDNPGCAKRAFREGKIGSFIGIEGGHQVGSSIAALRQAFYAGARYMTLTHNCDNAWATAASTVRAGKPDLGMTDFGPALIKEMNRLGMLVDLSHVSHQTMRDVLKITKAPVIFSHSSAYEVSKHLRNVPDDVLKTVAKNNGVVMVTFVSSFVKVDDPDSADVNTVVKHIFHIAEVAGWDHVGLGGDYDGTTELPKGLEDVSKYPYLIEKVLEAGATEEQARKLVGENVLRVWTEVEQIAKKIQRSGVLPVEEVWKGRNGTALSERSTFIEGPAPLEYGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEU5</accession>
    <name>D4DEU5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05685</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020246.1">
        <property type="nucleotide sequence ID" value="XM_003020200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEU5"/>
    <dbReference type="GeneID" id="9582787"/>
    <dbReference type="KEGG" id="tve:TRV_05685"/>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000228">
        <property type="entry name" value="Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.640">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="45"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="768"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="804" mass="90137" checksum="22DEEFBDE2494D13" modified="2010-05-18" version="1">MAAPREQPPWQQPTPHQGLQRELPPLKIWNSLTRSKTPFVPLDPEGKKVTWYACGPTVYDDAHLGHARNYVSADIVRRILRDYFKFDVKYIMNITDVDDKIITRGRQQHLYNQFSAEHPSIDQELLDTAKAAYEAYITKNLPLVPASTPAHELKDTAEKVYAAVLDGKPLEGNSKPGEPEAKVKMYIKTLSTAAEALTVASTPGGSIPVATFYDKTQDILYPYLDTLKGASIQGSDHSIFTRLTKEYEDRFMQDVRDLNVLDPDEITRVTEFMPEIVSFVERIIEHKFGYVTPDGSVYFDIENFEAAGNSYARLEPWNRNDANRQSEGEGSLSNKQAEKKSSADFALWKASKAGEPSWPSPWGNGRPGWHIECSAMASSRLGKQMDIHSGGIDLAFPHHDNEIAQSEAYWSSTCSHVQWVNYFIHMGHLSIQGSKMSKSLKNFTTIRDALQRGDWTPRSLRIVFLLGGWRDGIEITDEIVKAGNAWEEKVNNFFIRAKDPSVKLPETTSDEELPAALKAAQDSVHKHLCDSFNTAGAMYAISELITKFNNTSEAALSAQNTHAVAKWLTSMVNIFGLNSTAGPDSENIGWHGDEIAEEAKPYVYPLSTIRDTLRQTAIAKTGLTPDSIRSVVEEGRKSITPELLDPQLTNSFKDVFNNFCSSATALTESSNLSKEILDLCDTLRNTGLFDLGVYLEDRADLPARVRPVTRDLLQARQEAETRARQKLLEKEAREKEAAEKAAKGKVSPLEMFKTEAYSAWDEDGLPLKDAKGEEITKSQKKKLKKEWDRQKKAHETWLASQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF71</accession>
    <name>D4DF71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000335">
        <property type="protein sequence ID" value="EFE39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020122.1">
        <property type="nucleotide sequence ID" value="XM_003020076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF71"/>
    <dbReference type="GeneID" id="9583887"/>
    <dbReference type="KEGG" id="tve:TRV_05816"/>
    <dbReference type="HOGENOM" id="CLU_1908215_0_0_1"/>
    <dbReference type="OrthoDB" id="61321at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="133" mass="14900" checksum="B63FBEDE713D5260" modified="2010-05-18" version="1">MEAFISTGHADPSTYLEFEVSPNNVTYQAFVYNPSKNRTDGAPFDHAFISNPIADGITSKTSLAQTQGKWTSNVQIPLALFNVDTPQGSKWRMNFFRTVTSKETYPDQILGAWSSPDKASFHITSIFRKIIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFH1</accession>
    <name>D4DFH1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III transcription factor subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000338">
        <property type="protein sequence ID" value="EFE39401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020025.1">
        <property type="nucleotide sequence ID" value="XM_003019979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFH1"/>
    <dbReference type="GeneID" id="9580194"/>
    <dbReference type="KEGG" id="tve:TRV_05921"/>
    <dbReference type="HOGENOM" id="CLU_016809_3_0_1"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="185"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="589" mass="67154" checksum="4AC6F2D242C87919" modified="2010-05-18" version="1">MSHEHAGGERTAPWYAVPPQDVVSVEHPCVVRNIDKAIDTLQGHAAISEMLDASNQDSPLTLMLNPEDVMSRPIRSTSKQTNNILLKVTVPKRTGRRRKRGSQDPFVDSHEDGEVTPLSQLDARGLLQRLREDARRYQVDVVGQDYLILHTPRQEALLYRNFERRYYHSNFEFDLSKGATSNVDIIPPPALSNNDVAFQYLYRQNPTVKRSIDPSGQVTTANTQRIVKIPTHLVSYDISAVPTEPQPNCPPLSDQDPTVHDTVAALRALFNERPAWTRRALRNKLPTPERKYALRIAIPYVGYLFRSGPWRDGIFKFGFDPRISPDYRIYQTLMFRLFPVSAEAEGREQENDPNAQFTTTTTPLSGRRHTLPRLSFENNTDPTLARSHIWTGEPPLSKDGKTWMIVDIEDPILARLLDPSSPDAHPPREKCDIYSCGWYGNVTLSIVRTIMRMKMTMMMEGRTDWPSEQELLPLLSLPSHVDSEEDLNKLTLVKDGLGPVPSHLLTEIRAVARNVPWKMDKMRERFRGAVGPLGRSEKRVRWDDQPDEDEDDGEGEEQEQDQDDDEDDEDEVMGDYDEGEDIDIEPQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFJ7</accession>
    <name>D4DFJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019979.1">
        <property type="nucleotide sequence ID" value="XM_003019933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFJ7"/>
    <dbReference type="GeneID" id="9584733"/>
    <dbReference type="KEGG" id="tve:TRV_05948"/>
    <dbReference type="HOGENOM" id="CLU_2086547_0_0_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12977" checksum="80D19D615EE5FD4C" modified="2010-05-18" version="1">MDRVDGYNVYIGSLFALRNQDALKEANITHVISAVGPKERPSAISSLQTYDGIRGHLTLDLLDQDKENIIQHFPQAVRFMEAAIADGGAVLVHWLDTIYPLLPLEDTCICNISDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFT9</accession>
    <name>D4DFT9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="2">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019939.1">
        <property type="nucleotide sequence ID" value="XM_003019893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFT9"/>
    <dbReference type="GeneID" id="9584690"/>
    <dbReference type="KEGG" id="tve:TRV_06041"/>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="80"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="416" mass="46587" checksum="A176EAA4781F67F9" modified="2010-05-18" version="1">MFSRLIRARGVAQVGRQPSTQLFRRSVTTDAASAHAEDIPVEDDKPFSVKLSDESFETYELDPPPYTLKTTKKELKQMYYDMVSIRRMEMAADRLYKEKKIRGFCHLSTGQEAVATGIEHAITPDDKLITAYRCHGFAMMRGGTVRSIIGELLGRREGIAYGKGGSMHMFAKNFFGGNGIVGAQVPVGAGLAFAQQYNGEANTTICLYGDGASNQGQVFEAFNMAKLWNLPVIFGCESTFQIVFYPFLDNKYGMGTAANRSSALTDYYKRGQYIPGIKINGMDVLAIKAAVQYGREYTVSGQGPLVFEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTNDPIAGLKQKLLDWNITSEEELKAIDKDARSMVDEEVAIAEKMPVPDATSRILFEDIYVRGSEPKWMRGRTADETFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ2</accession>
    <name>D4DGJ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAM domain methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019667.1">
        <property type="nucleotide sequence ID" value="XM_003019621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ2"/>
    <dbReference type="GeneID" id="9583584"/>
    <dbReference type="KEGG" id="tve:TRV_06296"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_1_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="386" mass="44229" checksum="14E2BE71341F1399" modified="2010-05-18" version="1">MTTNPESGPDEMTDPPAATDHEVRAITPDEPRLKYSELICFHSAVPCHSLRVSPITPWKVVGDTIDTMKEVSSHRIMDVTSSSFFFFFFWLSRGSIAVKANSSSIAYLYPNDEIELDRLDMQYEIIRMVNEGRIFFAPLDNPERLLDIGTGSGIWPIEMAEIFPDAQIIGTDLSPVQPGQVPPNVQFFVDDAQEEDWLWPKDHFDYIRSSMLLGALNSYKSLINTARTYLKPGGYMECHEWDVALFCDDDTLPAPQDDFQCPHEFQNWIQYLRLSTKNLDRPVFIVDKIADWMREAGFEDVKETITKIPLNPWPKDPHLKRLGAWSERNWLDGIAAFSYAPFGARGLGWTQEEIEVFLVGVRRSISDRKVHSYQRFHVVTGRKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGL8</accession>
    <name>D4DGL8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019651.1">
        <property type="nucleotide sequence ID" value="XM_003019605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGL8"/>
    <dbReference type="GeneID" id="9583551"/>
    <dbReference type="KEGG" id="tve:TRV_06323"/>
    <dbReference type="HOGENOM" id="CLU_022564_2_0_1"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="576" mass="63272" checksum="F7F03B172CE064E8" modified="2010-05-18" version="1">MAELRSRPSSVLLEPPPKGVELEDPGASDHTPDSDDEHFSDATEGQTSASRRPSRSQSPVPRTRVEKVDTSPRHGEVPGSPAYQQRLADAVPDEIDIIGGARTDTQHNPAHIERPLTPGGTPIPLTVVEKVDINSPAYGEEPGTQAYESRKADFAPDRIFKLGDPRASPQLVVPENDLENAISDSDLPETLLSKVESLPKEGEERRFTAHRRKLSDAAPDAEEIVLDVPGQQIPDTNSSGTKIKFTDDPAQLDDSGGDLKDYTETRADFDDNDNGFGDDFDDFKEGDGGDDHDDFGDFDDGFQEPEETSDAAILKPNTDSTASPNLPVLPPLLDFSSLKSLPDLLSATSDHLDTLFPNSKNLSSLPPIDPFPDSSAIFTTERSLSLWSQLVAPPPLQPPNWTKSRIRRLFLVSLGVPVDLDEILPASKQKKLVLPSMNRDTARVSSEDPLGTGGTLLRSRSKRKNREGQPRSSTSFDSNRSSSRPVPSTPRRRGNTPPPELDLLATRRLCETTDAALDGYTDQEITEHVQKLEKLTIRASEVLEYWLKKRDGQLGEKEAFEGVIENLVKHARQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGQ9</accession>
    <name>D4DGQ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannan polymerase II complex ANP1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000362">
        <property type="protein sequence ID" value="EFE38960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019605.1">
        <property type="nucleotide sequence ID" value="XM_003019559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGQ9"/>
    <dbReference type="GeneID" id="9580140"/>
    <dbReference type="KEGG" id="tve:TRV_06364"/>
    <dbReference type="HOGENOM" id="CLU_017872_3_1_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="610"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="86403" checksum="6D60EF31F16A0F7E" modified="2010-05-18" version="1">MGALRTTGYPPSAFFPLVFSVDLHPGRGMKIAGHGVFLLHIQHNTAAADTESTYIYHKPLRTTRHSLAVGTHVDIGHRLLRTTVYTSVYIGAEESEKTSKKPTDEQKKRRRRRLSVSLACLAKYWTLKRLVLAAAGTSEGCGLLTPFAIFVSFSPLWPLVLFHHLLFFFSASLLYFYFSSPAIKAAAAADAARGDMNRHSAFSNGYTAAPKRESGTFSISPHRDEDEDGEMKKIADWQRFQPRSQPALRRRRALLQRLVVGGLLSIGLLLFLFPSWRPSVLGAASLGLFAASDDFQLETVRYYDLSNVEGTPRGWEREERVLLCTPLRDAAPHLPMFFSHLRNFTYPHHLIDLAFLVSDSKDDTSGLLTKLLEELQNDPDPRQPYGEISVIEKDFGQKVNQDVESRHGFAAQASRRKLMAQARNWLLSATLRPTHSWVYWRDADVETAPFTILEDLMRHNKDVIVPSVDVWRPLPDWLGGEQPYDLNSWQESETALALADTLDEDAVIVEGYAEYATWRPHLAYLRDPFGDPDMEMEIDGVGGVSILAKAKVFRAGVHFPAFSFEKHAETEAFGKMSKRMKFSVVGLPHYTIWHLYEPSVDDLRHMKEMERERKQREAEEKEKKEKAKKIKEQFKDSSVESEKDSAAVHDIMQKDKTQQQLKEKEKKKQQQQEKDKASKQSNDGSDKTDKTDSKKEVNNEVKNEVRKDVKDVKDEAKEEAGKPDDKTQAQRSNGQKTSDKQKQKPRDKAREASRGEQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHB8</accession>
    <name>D4DHB8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_06574</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019407.1">
        <property type="nucleotide sequence ID" value="XM_003019361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHB8"/>
    <dbReference type="GeneID" id="9580123"/>
    <dbReference type="KEGG" id="tve:TRV_06574"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="486" mass="54154" checksum="64F84CFB419BA4B2" modified="2010-05-18" version="1">MLKNRRDYIDSAADRGEIREKAEDDEEEEEEEEAEERERERVRAEMADNKDGNDAPAVPQTNGTRVPKKRFVGRKTAEAQAQRTGGEDVEQSHTTAIQTASTRRGPRALNQIPAAILEDEDIKAAISLLPHNYSFEIPKTIHRIRSSGAKRVALQFPEGLLLFATTISDILNQFCPGIETVIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYIFVDIGIDTPHLIDTLKRNFTSGQRIAVVGTIQFNATLHGLKPVLEKEGFNITVPQIMPLSKGEILGCTSPRMSSEAVDLLLYLGDGRFHLESAMIHNPSIPAYRYDPYSRTLTRERYDHEEMQDLRRKAIDVAKSAKRWGIILGSLGRQGNPNTMKMIEEHLNEKGIPYVNLLLSEIFPGKLASMPDVDCWVQIACPRLSIDWGYAFPKPLLTPYEALIALGIKEDWNKANGGIYPMDFYAKEGLGRIKPGTTVASLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHL6</accession>
    <name>D4DHL6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_06672</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019328.1">
        <property type="nucleotide sequence ID" value="XM_003019282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHL6"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="9577650"/>
    <dbReference type="KEGG" id="tve:TRV_06672"/>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055533" description="P/Homo B domain-containing protein" evidence="20">
        <location>
            <begin position="22"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="21">
        <location>
            <begin position="487"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="628"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="776"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE38683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="846" mass="92593" checksum="F96815DCA8F91139" modified="2010-05-18" version="1">MKLRNIFRLMALLVGAGAVDAALYRRDYDALDYFAVHLHSSVSPAQVEELLGARHEGQIGELDGHHTFSIKKDRGVDLDGILEDLKRRSLRRRSLEARGEPAGTDGLDGILWSEKLVPRKRLHKRVPPPPLELSQRIPEKAPDPAAQSRQGEIANALAIRDPLFKEQWHLFNAFTPGNDLNVTGLWLEGITGKGSISAIVDDGLDMYSNDLKDNYFAKGSYDFNEMKAEPRPMLDDDKHGTRCAGEVAAVHNNACGVGVAYDSKVAGIRILSKYINDADEAEAVNYGFQDNQIYSCSWGPIDDGMTMDAPGLLVRRAIANGVQKGRGGKGSVFVFAAGNGAGHDDNCNFDGYTNSIFSITVGSVDWNNEHPYYSESCSAQLVVTYSSGSGGYIHTTDVGADTCSGSHGGTSAAGPLVVGVMALALQVRPELTWRDLQYILVETAVPINETSDGWQTTSIGRKFSHDFGYGKVDAYSTVHLAKTWKLVKPQAWFHSPWLKVYHNIPQGDKGVSTAFDISPEMLKAHNLERVEHVTVTMNVNHTRRGDLSVELRSPSGVISYLSTARAQDSERAGYVDWTFMSVAHWGEKGTGVWTVIVKDTVVNDHNGTFLDWRLTLWGESIDPKIQKLHPLPDAHDHDHDTAIPAPHVGTASVQPGPTKTSPPFRPTDHIDRPARPKPTSSKKPTPTTTTTATTTSTATAASAPSTGASGENFLPSPFPTFGVSKYTQIWIYGSIALIIVFCTALGVYFWIQRRKRLRNDRNEYEFEMVAEEDEGFPLSGAGARGKKSTRRGGELYDAFAGDSDDEDPLFSSEEDDSNEYADAAEDDDSYHDEGPEVTPPESTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHN7</accession>
    <name>D4DHN7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019289.1">
        <property type="nucleotide sequence ID" value="XM_003019243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHN7"/>
    <dbReference type="GeneID" id="9577611"/>
    <dbReference type="KEGG" id="tve:TRV_06693"/>
    <dbReference type="HOGENOM" id="CLU_046577_1_0_1"/>
    <dbReference type="OrthoDB" id="5365129at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017061" evidence="2">
        <location>
            <begin position="16"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="36419" checksum="B5BD41C3EC7C1E50" modified="2010-05-18" version="1">MAFVNMLGIIAGSLGIISFGLDRFGGEGSHSGSTIKVAVALDGPQLSNSAGDLPDVRVWNEVGKFVGITVDPGRVEAGNIGEIKVQHDNQGVYTLFSANDDAVCIAWVSTTWTDDRGGNKYAVTGDFSEPCGGAWFPSNLYISDKKDHQPDCFWIDKNGDQPKTGFQVRWPAYSEDQFEGNNKDPKRLCNNIDFGLREENDPSSINYYPKKKRDEHPRARRSTIRRPGWANSELVISDSKHHSARRLCMSGSSMGPDFAHTEEGFFCDMDTKVLYAFCADIEEKSACFDLKRQRIVAHEEATGVNATSTSHGSARYSRIRDWRTNSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHR8</accession>
    <name>D4DHR8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019236.1">
        <property type="nucleotide sequence ID" value="XM_003019190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHR8"/>
    <dbReference type="GeneID" id="9577490"/>
    <dbReference type="KEGG" id="tve:TRV_06725"/>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="32085" checksum="7E1C3282308669F8" modified="2010-05-18" version="1" fragment="single">GMVKNLVEKGPLSKPLIVYNRTQSKAIDLAKTLSQQIIPVSTVKEAVEKATIIFICLGDDPAVESTIDTALKSTDVKGKLFVDCSTVAPDTTRRLAQLLESSGASFAACPVFGAPSAAEAGTLVCVLAGRKESVERVKPFCTGVMGHAIMDLSTKSEDPGKASMLKVLGNSVIFRMVSAVSESLVVAEKSELGVEAIHSFLELFFPGAAVAYSNRMVSGMYHTLEEPLFAVDLARKDTRHVMDMAKAVGVRMKGVEVLDEALQAAKSHSGAKGDLSAIYGVARQDAGLKFENNQLGQGSYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHZ8</accession>
    <name>D4DHZ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000390">
        <property type="protein sequence ID" value="EFE38520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019165.1">
        <property type="nucleotide sequence ID" value="XM_003019119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHZ8"/>
    <dbReference type="GeneID" id="9577167"/>
    <dbReference type="KEGG" id="tve:TRV_06805"/>
    <dbReference type="HOGENOM" id="CLU_033907_0_0_1"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="318" mass="35464" checksum="316858FA0ACDCB1F" modified="2010-05-18" version="1" fragment="single">GKRLFIKDMAYYIMPPDAQPATRVASLQIPKRGIGTNMDTNGASSNGVARAQDSETPHRTNGSISAPETNPEADNPTVIPQELLSKFHFAFLIRDPHYSIPSYYRCTIPPLDDVTGFYEFYENESGYDELRRFFDYLRKIQFVGPSHASTVHTGNANATLNGTVNGTTNGTTNGIHSEPEKVEICVVDADDLLDNPAAVIERFCKSVGEEYTPEMLQWSSEKDQKVAHDAFAKWHGFHDDALGSKSLRPRAHGVAIFGTCTADTYSSVANKKKAAKTEEEFDAEWKEKYGEKGAKIIRSAVDRNMADYRYLKKFAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI78</accession>
    <name>D4DI78_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019107.1">
        <property type="nucleotide sequence ID" value="XM_003019061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI78"/>
    <dbReference type="GeneID" id="9582593"/>
    <dbReference type="KEGG" id="tve:TRV_06886"/>
    <dbReference type="HOGENOM" id="CLU_2833013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="66" mass="7079" checksum="E795B7DAA77E1E1E" modified="2010-05-18" version="1">MATLHCLHDPGGERCETGLIPLIDGESDIVRNGGLSGGGEKEDEEEAGGKKARGWVEGEGSWNRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIA3</accession>
    <name>D4DIA3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019086.1">
        <property type="nucleotide sequence ID" value="XM_003019040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIA3"/>
    <dbReference type="GeneID" id="9582572"/>
    <dbReference type="KEGG" id="tve:TRV_06911"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="61682" checksum="6254C8E542710A9C" modified="2010-05-18" version="1">MRPDSNELHNCWALANMREATAACSRNDTITIPTEAGVHSQADTISTVISTQKTWRFWAIFPALCMTTFLSALDTSILSTALPTISKDLGAGPLYIWITNAYVLSSTVTQPLFGQSANIFGRRWLLILSVVWFAVGSGLAGGANGTTVIILGRTIQGIGGGGINTLIDIVIGDLVPMRERGKYVALMGVIWAIGTVIGPVLGGGLAEHASWRWIFYINLPLSGLSLILLYFFLRVASPPGNGFYKQLLRVDFIGNVILVMAVISILLSLTWAGTLYPWSSWKIILPLAIGFLGLILFYAHQTSRFCREPSIPLRLFPTPTSLFSLILGFTGSILIYWVGYFLPVYFQAVLGTSATKSGLFVLPITGAVAPFGILAGILISVWGKYRAFHFIGFGLMSIAVGLFSVLDQYSSAGYWAGFQIIFGAGSGLIYSSTLPPIQASLHESDMATATATWAFMRSFGSIWGVAIPTAIFNEKTESLLGGISDPSLRRQLSNGGAYALASSGLSSSLMHDPKLLSEVIGLYTQSLRFVWLLAIPFGICGFVASIPIRQLELKTHLETEFGLQEQRQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIE6</accession>
    <name>D4DIE6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TRV_06954</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018943.1">
        <property type="nucleotide sequence ID" value="XM_003018897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIE6"/>
    <dbReference type="GeneID" id="9582101"/>
    <dbReference type="KEGG" id="tve:TRV_06954"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="802"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE38298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="899" mass="100113" checksum="6C4E5C8B97C89C32" modified="2010-05-18" version="1">MDKLKETRNHNPAWIKQRRFLSLILFLIAALLTIIIIFLFWGSQESLDRPRLQRKYHIPDRTFPMKQRSPQVKTVPRWQDSYFKAQSLVNNMTLVEKVNVTTGVGWQMGLCVGIRFADNITAFPAGITVGATWNRELMYKRGEALGREARRKGVNVLLGPSMGPLGVLPAGGRNWEGFGTDPVLQGIASAETIRGTQNEGVIATAKHFVLNEQEHFRQPHEWNNSEAMSTNIDDRTLHEVYVWPFSESVRAGVGSVMCAYQMVNNTYSCNNNRLLNGILKDELAFQGFVQSDWYGQQVGVESALAGMDVSMPGEIHYSDSGESFWGPNLTTAVLNGSIEVGKLNYMVTRIVAAWYQLKQDEWEKPPPDGRGGPNFSSWTKNKTGHLHEGSDDDQNVTVNRYVRAPNVWNNSHIDLAREIAAEGTVLLKNEDGILPLSAKGTTSDRKTKVGVFGEDAGPGDGPNVCPDRSCNQGTLGSGWGSGAVDFPYLITPWDEIKKTYDSNNVSLNEYLYNGIQDNDLEDKDLCIVFANADSGEGFASWEGIYGDRNDLSIQKDGNNLIRQASDKCGKGKGSTIVVLHSVGPVMMEDWIEEPGVKAVVLANLPGQESGRALGDVLFGRVDATGRLPYTIAKDPEDYGPESKVLYESNDVVPQKNFTQGLYFDYRYFDKQNITPRYEFGYGLSYTSFQLSGINIKALSQKSATANSRSEVNVTLPSYNESIPDPNSALFPEGFNGLERYVYPYISSVDDVQETERLHFLRRRTDEYNLTAGGGEGGNPSLFESMVNVSLTVNNTGERAGKTVVQLYVSFPSGVNETVKEEGEDEDERVISIDFPNRVLRNFEKVELQPGQSKEVTLSLTRKDLSYWSIYQQNWIIPTAGKFKIWAGQSSRDLPLTGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIL2</accession>
    <name>D4DIL2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019009.1">
        <property type="nucleotide sequence ID" value="XM_003018963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIL2"/>
    <dbReference type="GeneID" id="9582333"/>
    <dbReference type="KEGG" id="tve:TRV_07022"/>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1045"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1112" mass="121862" checksum="D50A9DAC57C2A0B6" modified="2010-05-18" version="1">MKPNTSQKASAAQTPSSSSSNVNPEYREIKAKFAKLLAEEEAKRAAGAGKPSQRAKKPPVDQSELAKRAKQQDDKRNKEKENEFKIQHIGILLLLGWFGLVHIIGIYFFTKGFLLTRLVLEDKSQCDVLPLQDLPDAIAPANLGIDAPKDGAGKGCWHPKTFDKAVVVIIDALRYDFTVPSKRMVEGGPPRLYHDNIPVFYDTAVNSPNDAFLLPFIADPPTTTLQRLKGLTTGTLPTFIDAGSNFAGTAIDEDNIIAQLKSAGKRVVHLGDDTWHALFPGYFEEELTHAYDSFNVWDLFTVDNGVTEHIFPLLHADNSTKWDVLIGHYLGVDHAGHRYGPDHPAMADKLAEMDALIRKMMDAIDDQTLLVVMGDHGMDPKGDHGGESDDEIEAALWMYSKKGVFGRVSDDSLLPPTTAKERPIPQIDLVPTLSLLLGLPIPFNNLGSPIEEAFAGKSGQDFRNLAAVSRLTSAQIKRYQHEYSKARGNEAAQTSNPLSKWSEAEQNWKDIHDSGHNKKVTYQAAYSTYREYQRLTLSVCKGLWAKFDIPSMAQGIAILISGVTLLLYYARAIRGNRTNITYFTLRKIGYGSLAGVGVGAILNVSLALDLHIAESIALGCVTGGVISAASMVLQSQKTIGTVIPRSLWGWAMFIFTIAQSVGFASNSYTIWEDQILLFFLTTFGVVAAFSSLRQKVTADRVLGFYHSIVFTLLGRVASMSKLCREEQMPYCKSTYYASNNSSTSSPLQLLIPFFLSLLLPAVIRSYYQGTKSYEGSAIFWIGFALRMGLLIVAVYWTLDAADDGDWFTIRKDHMKSARMILAQVVLAIAFAAGSTTFAWAKPCVSIGVTPNSTQSGEAKTSVTILGYANIYGTRYFLLLVNFTLAIILLQKPMGGGAVGLQIWQILSLMEILDTNNLTTTNSATGPIVLALLGSFHYFTTGHQATLSSIQWETAFIPLKTVQYPWSPILVTMNTFGPQILAALAVPLTVLWKRPIESRLNSKPPISAPAASSPVPAQGDSQKASKQSSPANKLLSDVAQATATHMLYYATISLATTMWAGWLRRHLMLYRIFCPRFMMGAAVLAVVDIAAIFIAAGGVRWSTLSVGEIFGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIM1</accession>
    <name>D4DIM1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019018.1">
        <property type="nucleotide sequence ID" value="XM_003018972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIM1"/>
    <dbReference type="GeneID" id="9582423"/>
    <dbReference type="KEGG" id="tve:TRV_07031"/>
    <dbReference type="HOGENOM" id="CLU_003246_0_1_1"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="11">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="12">
        <location>
            <begin position="461"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="802" mass="88286" checksum="EF34E46C00BFCFD1" modified="2010-05-18" version="1">MATTSSMFMYSLTIQPPTAITQAILGQFSGTKEQQIVTAAGSKLTLHRTDPSQGKVQTLFSQDVFGIIRSLAAFRLAGSSKDYIIIGSDSGRITIVEYVPAQNRFNRIHLETFGKSGVRRVVPGQYLAVDPKGRACLIASVEKNKLVYVLNRNAQAELTISSPLEAHRPQTVVFALTALDVGYENPIFAALEVEYTEVDQDPTGQAYEETEKMLVYYELDLGLNHVVRRWADPVDRTASMLFQVPGGADGPSGVLVCAEDNIVYRHSNQDAFRVPIPRRRGPTENPERKRCITAGVMHKMRGAFFFLLQSEDGDLFKVTMEMVEDENEKATGEVKRLKLKYFDTVPLASSLCILKSGFLFVASETGNQHFYQFEKLGDDDDEIEFISDDYSAVISEPLPPVYFRPRPAENLNLVESIASLNPLMAASIANITEEDAPQIYTLCGTSARSSFRTLKHGLEVSEIVESELPSVPSAVWTTKLSRNDQFDAYIVLSFSNGTLVLSIGETVEEVTDTGFLSSAPTLAVQQLGEDSLIQVHPKGIRHIHADQRVNEWPAPQHRSIVAATTNERQVAIALSSGEIVYFEMDTDGSLAEYDEKRQMSGTVTCLSLGEVPEGRGRSSFLAVGCDDSTVRILSLDPDSTLENKSVQALTSAPSALSIMSMIDSTSGGSTLYLHIGLYSGIYLRTVLDEVTGELSDTRTRFLGVKPVKLFSVSVKEQRAVLALSSRSWLGYSDVQTKSFTLTPLNYVGLEWSWNFSSEQCVEGMVGIQGQNLRYVSIIPSTVLCLCLLFLHDELQLLSPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ31</accession>
    <name>D4DJ31_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">TRV_07196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018794.1">
        <property type="nucleotide sequence ID" value="XM_003018748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ31"/>
    <dbReference type="GeneID" id="9581191"/>
    <dbReference type="KEGG" id="tve:TRV_07196"/>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="320" mass="35929" checksum="240907FADD88B9B7" modified="2010-05-18" version="1">MNMSSRSAWRGLHWSAKRRPMVSQAPYRCFSCSARLQSPGQQPDERKTHFGFETVRESEKESRVGAVFSSVARSYDTMNDFMSLGIHRLWKDYFVRSLNPGRQYAREGPGKSGSSEVEHQGWNILDVAGGTGDIAFRMLDHATNIKHDQYTRVTVADINPDMLTEGKKRSLDTPYYNSDRLSFMQGNAESMPSIPSNSVDLYTVAFGIRNFTNKQAALEEAYRILKPGGVFACLEFSKVTVGAFDEVYKRWSFGAIPLIGQLVAGDRASYQYLVESIERFPSQEEFRGMIRKAGFLTPGDGYENLSLGIAAIHKGVKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ96</accession>
    <name>D4DJ96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000428">
        <property type="protein sequence ID" value="EFE38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018717.1">
        <property type="nucleotide sequence ID" value="XM_003018671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ96"/>
    <dbReference type="GeneID" id="9581036"/>
    <dbReference type="KEGG" id="tve:TRV_07262"/>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="659" mass="72762" checksum="A7A95BD4C66A59B3" modified="2010-05-18" version="1">MESSSGLRRKDTTKGPPLRILSLDGGGVRGYSMLIILQELMYRTYVECEGKAPRRDQIPKPCEHFDLIAGTGTGGLIALMLGRLRMDIETCKEVYIRMTRRVFETDKTIAGIPYRTTLFKASKLEDAIKQCVRDHTVDEEEGNDGTTATSANPFMRSASTATLQRRLSRSSVSTTNTSVPTSPVTSQTLTVGGGQVWGDPNAKLYDNRENRTKTAVTAVYKGTPKTGTSILLRSYDSRREPPPEFNCTIWQAGRATAATGLAFKPIQIGQHIFLDEGAGKYNPSPQILDEAVVNEWPGREVGAFISIGTGKRPQGATSPPHEWWEDVFRDSLGNFAEARRRLIAKIEGCEATHQFMVKDHLVKRNVPREVYYRFNVEVGVGEFGMNEWSRLAEISTNTRMYLAKNEVQRMNYDAAVRLARVDRMHKRLEGRSGVPLAATNEALEERKNQPVPPIPPLKYREEAVDENVFELPAIELPAEEHLQQNRTPIQSQNQSHHRPGTSQSSTAISFSSYDDKFAVLPGNDDGRDLPEPVSGSAGRRSSEVLPISPARRSQDSHSQHQPSSSIDSSTRASSLDAHSRPAGPPPTGPPPPLPPKTPIPYPVSSEDVTVGAVSMPSLPPRNPDRPVSIVGPPRKYKLPYPDDGPPPVNRTRKPTYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJE9</accession>
    <name>D4DJE9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07315</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018627.1">
        <property type="nucleotide sequence ID" value="XM_003018581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJE9"/>
    <dbReference type="GeneID" id="9580778"/>
    <dbReference type="KEGG" id="tve:TRV_07315"/>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="496"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="628" mass="69775" checksum="59A72CEAFC255283" modified="2010-05-18" version="1">MTSRKTQQEIDKTFKKVGEGIQSFEGIYEKIRSSSNAAQRDKLEDNLKREIKKLQRFRDQIKTWAAGNEVKDKSPLLEQRRAIETCMEQFKAVEKEMKTKAYSKEGLSAAARLDPKEKEKADTCDFLSSTVDILQQKIEAMEAEEESIQASMKKGKKDIAKSNRLADIERLSERHKWHVGKLELLLRSLQNGNVETQQVLDAQEAIKYYAEDGHNPDFCGEDETIYDDIPLGDDEVQFGMNNDNDRVSSQDTQSIQEDDAESRQANKGKSDSGPARRPSTQMKSPLPVLATLHLNGPSSSSASSMKPAPPPARLPGETLKYASAAAAAAASDKAGVGIAPLPPPPGASPAVSAAQLASKASSTASPMVQPAQPVQVQRLMSSAGSADESGSQSKSPTLSPSVTAASRPGTMPPTPAMSKIETSATTPAASTSAPNKERTVTNGQAKGKSPDEPAADESVYHLPPGLQDLIHSFEVTKSRSTAPQSASVQRLLVASHSTCPEPGDAEKPRHYKPQTPYTTPLYYPQETLPIFDDPRLYETGRIDTDTLFYLFYYRQSTYQQYLAAKALKNQSWRFHKLYQTWFQRHEEPKNITEEYEQGTYRFFDYESTWMNRRKGDFKFVYKYLEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJZ1</accession>
    <name>D4DJZ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018486.1">
        <property type="nucleotide sequence ID" value="XM_003018440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJZ1"/>
    <dbReference type="GeneID" id="9584415"/>
    <dbReference type="KEGG" id="tve:TRV_07500"/>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056325" description="Histidine acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="50619" checksum="8B581C40D0E9937F" modified="2010-05-18" version="1">MLNSASLLAVSLLAQAATAETVLGAYIFSRHGDRTSKSTPPTVLTDLGYSQVYSSGRYYRDRYISSSSSSQVLGISPNIISPGEITASAPQDEVLQKSALAFFQGLYPPAGKEAKTTLRNGTVIEAPMDGYQLVAIEQVKSGSNSENIAWLQSASACKNAKISSNDYFASKEYKDLLKSTEGFYEDVAPLVKDTIVAEKVNFKNAYTVFDLLNVASIHNSSDSFPSLSSEVYSQLQSLANIHEFGLAYNASEPIRAVSGALLAGEVLNSFMDTIKAPKTKPKVNVQFGAYATFLSFFGLTKLPTANHDFNGIPDYASTMVFELVTNASTSSGSFPAESEISVRFLFHNGTTIPGSPETEPTAYPLFGQEKTLLPWSDFVSHMKEIAITSQDQWCQACGSASEGCPGAPSSGGPSGPSTSSNSDSGISRPVAGVIGALVTLSVILSVQALVFFVGGFTITRKSKRVNSIGEMKQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKA1</accession>
    <name>D4DKA1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000457">
        <property type="protein sequence ID" value="EFE37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018367.1">
        <property type="nucleotide sequence ID" value="XM_003018321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKA1"/>
    <dbReference type="GeneID" id="9584295"/>
    <dbReference type="KEGG" id="tve:TRV_07622"/>
    <dbReference type="HOGENOM" id="CLU_011856_6_2_1"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56066" checksum="CDA369CB6A55685C" modified="2010-05-18" version="1">MERNHLKDGVGIQVDDSHSKELWETALNPPSRSVLPPAASLEQSRSSIITELSHTGQGYTQTKDHLFNDIIPGLNDSAINANYYGFVTGGVTPAALLADNVVSVYDQNVCVHLVDHSIATDVDYAALCLLKDLFGLKRDEWPHGIFTTGATASNLVGLACGREYVLRKAAQKRGASGDIASGNITDSVGEYGMPAVLEAAGLKGLQVLSTMPHSSVGKVAGILGIGRANVKSIVSNTGESHGQPLEFDFELFEKELARDGFASIVSISCGEVNTGRFATKGIDEFRRVRALCDKYNAWLHVDAAFGMFGRVLDDSPEFEIIKKGSEGIELADSITGDGHKLLNVPYDCGFFFSRHGDVAEEVFRNPNAVYLSSSSGEHIPTPLNIGVENSRRFRALPVYSTLVAYGKDGYRAMVERQIRLARLVTGWLHEHPKYTILGGGASKEDLIAATYVIVLFRAKDEALNARLASAINGTGKMFVSGTKWAGEPACRVAISNWKVQVERDFTLIKEVLDEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKA4</accession>
    <name>D4DKA4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000458">
        <property type="protein sequence ID" value="EFE37719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018364.1">
        <property type="nucleotide sequence ID" value="XM_003018318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKA4"/>
    <dbReference type="GeneID" id="9584292"/>
    <dbReference type="KEGG" id="tve:TRV_07625"/>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="388"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="552"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="871" mass="98748" checksum="0389FC799233BFF2" modified="2010-05-18" version="1">MAHQDAHEVLQLVQRLEAAQKKQVKRAFTCKKSTFEVAGSDITVDSWRFQDWDYKDRGLPTYARGLFTTTNRAGKPEIAVRGYDKFFNIEEVNLTRWRNIEVNTRGPYELSVKENGCIIFISGLEDGTLLVCSKHSTGSRQDMEMSHAEVGRAWVRKHVESVGKTERDLARELRSMNATAVGELCDDSFEEHVLAYSEEESGIYLHGINYNLPEFATVRSPDVHRFADAWGFKKAQFLVKDDIESVRTFLEGCAETGSWDGRDTEGFVIRCQMRESSSLPYHDWFFKYKFEEPYLMYRQWREATKKLISGKLPTFKKHVKITEEYLKYARKQLAKDPKLAKLYNQNHGIIAMRDGFLKERGLKGSEIIAMEAAEGGELEAAQDNKDFVLVPVASIGCGKTTLAVALVKLFGWGHFQNDNVEGKGNRPKRFVQGLVNELMNHSCVIADRNNHQRREREQIFTDMQTLVPNAHFIALHWVHEPKGALLDDIRRVTQQRVLDRGDNHQTIRAGSKSESEILQIMEGFLRRFEGVDTFRQPDRHFEGVIDLDVAASSRENLETIVDYFYANYPKLMKRDKPDAAELDAAIKEAMEGYTVDIKHDLNFKSKNQPQKQQHQQQQQQNQKNQKPQTLDQLVKKIEYFNISVPSAPIHSILSSVFDASSSPDYAHLYRLLTNSRRIQPSFHVTLIHRASSSDHPQIWHTYTDLYKAAVVQEQQQQQQTSSSSAASFPGSATVTGTPTPSLGTASVRLETLVWDKRIMAIVARILSGPPSLDTTTGVAAAALPISGEAYGDRREEEERQGERELPPTWPCANEIAHVTIGTANASVKPKESNDLLKRWLTMGAGEESGIWEAKIPSVKVVEGLVGVVMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH0</accession>
    <name>D4DKH0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018288.1">
        <property type="nucleotide sequence ID" value="XM_003018242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH0"/>
    <dbReference type="GeneID" id="9579994"/>
    <dbReference type="KEGG" id="tve:TRV_07692"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31645" checksum="DB14EF79D5BBF1EA" modified="2010-05-18" version="1">MADYNLNRRLPPIRACLFDMDGLLIDSEDIYTFVINQILHEYGKPNLPWSIKAQLQGRPQPQSGQVFQKWAQLPISQEELQKKIAALQRPQFPKTQPLPGVMQLISNLSRAASNSPPVHIALATSSTTTNFKLKTSHLSGLFSQFPPSRIIVGDDPRIAPGRGKPLPDIYLLALSIINKEIQAKGEHPITPAECLVFEDSVPGVEAGRRAGMRVVWCPYEGLLEVYKTQVPEVLAGLTGAHKDPEDNGNDTSAVSNSGKPGNLNDGWGELVRSLENFPYEKYGIKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKI1</accession>
    <name>D4DKI1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin aldehyde-forming enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018253.1">
        <property type="nucleotide sequence ID" value="XM_003018207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKI1"/>
    <dbReference type="GeneID" id="9579868"/>
    <dbReference type="KEGG" id="tve:TRV_07703"/>
    <dbReference type="HOGENOM" id="CLU_1897704_0_0_1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="134" mass="14302" checksum="B537E0AF2A571F6A" modified="2010-05-18" version="1">MDNYAPSHPVSPISQPPSSPSSPSSLKRYELGLDLSDKAIETAAHPKPTAPHLSLIEVPRRKPVPPPKAVFADQTEPHVEAPPAGQSGGGLKGKIRDLWLFKRRMVLTVAAVVAVLLLGLIIGLAVGLTRHKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ6</accession>
    <name>D4DKZ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000485">
        <property type="protein sequence ID" value="EFE37468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018113.1">
        <property type="nucleotide sequence ID" value="XM_003018067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ6"/>
    <dbReference type="GeneID" id="9579331"/>
    <dbReference type="KEGG" id="tve:TRV_07870"/>
    <dbReference type="HOGENOM" id="CLU_047725_1_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33208" checksum="DBD527FFC64ED1A0" modified="2010-05-18" version="1">MSEQIIERFPVSAGPDAIFESFKKNGVVVIENFVKKDQLDRFTAEIDPALQKLTAGYASRIDGDEPVDDFFGKKTKRLGQLSTVSSVFRHEFLEHDLMHSLLERNFIDHPQAEYWMNTSDVIEIGPGSKPQPIHRDLELYHPFIIGGPAMPEAVCNFMVALTPFTAENGATVFAPGTHLNESFERLEDGELPGGDKTISAVMNPGDCAFFSGKVIHGGGTNSTADEFRRGLSMSFIRRILSPEQAHPLSISREIIETMSYRGQAMLGFRSNWPAIGDEPAIIWSYQGSDIGKKLGLGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL59</accession>
    <name>D4DL59_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018045.1">
        <property type="nucleotide sequence ID" value="XM_003017999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL59"/>
    <dbReference type="GeneID" id="9579179"/>
    <dbReference type="KEGG" id="tve:TRV_07933"/>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="28994" checksum="7BAC9AEC0FC8187F" modified="2010-05-18" version="1">MPGVDVTADIETLHLPRILCLHGGGSNARIFYTQCRVMRAHLKSTFRLCFVDAPFSSPAGPGIESVYEDYAPFYCWHNWKPGVTEDFGGQTLNYVEKILREAMAEDDAKGATGKWVGILGFSQGAKTSASILMKQQVQTELNIRDENSFDFKFGVIMNGRGPLLELGLDYGSDSSAPGSSASSATEQSEDIKSASGLLHIPTIHVHGRRDPGLYLHRHLRDSSFVKSTTRLVEWDGDHRLPIKFNDVDALVSQIHAVAKETGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL90</accession>
    <name>D4DL90_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000496">
        <property type="protein sequence ID" value="EFE37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018023.1">
        <property type="nucleotide sequence ID" value="XM_003017977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL90"/>
    <dbReference type="GeneID" id="9579155"/>
    <dbReference type="KEGG" id="tve:TRV_07964"/>
    <dbReference type="HOGENOM" id="CLU_061437_0_0_1"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="32664" checksum="64033DF865937925" modified="2010-05-18" version="1">MEGEFRFEDYIRTWSPSPPPQDSQVGLHNSSANPDEGHPTSQATDPQPPTSQAADPQVGLHGYCVDSAQGLPITQATNPQPHISQATDPQLPISQATNPQPSIIQATNPQPPISQATNPQVGPHNSSANSAQGPPITAVIAGIHQGWMARYRSHESEFRRAHNSRERAFICASRRTGRDISIRMQSARNASKCHYFNTGRWFKFNEDDVRNCRDFDITFELPAYWDEEIQPPTTWNSTWPPPKYATDWDMKPTLPPPIPLEAFQKMQVNAENVVLAVRGGNPRPTGPPPGYEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC6</accession>
    <name>D4DLC6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017996.1">
        <property type="nucleotide sequence ID" value="XM_003017950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC6"/>
    <dbReference type="GeneID" id="9579124"/>
    <dbReference type="KEGG" id="tve:TRV_08000"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="26169" checksum="1400F7BA8C79B881" modified="2010-05-18" version="1">MDPDYNAKFAIHEAAREGKNLVVESLLNANPKLAYLKDGDERLPIHWAVAYNRPPIIELLISMKGFDPDVTNKDASGWTPLMIAASLKDGEGDAIVDQLLRKDADVNMKTSSGQNAIHFATSKNNISTVRKLLENKCSARVKDKRGQLPLHRAAAIGSVPLVKLLIEEGKSPLNATDVDGLTALHHAISEGHGEAALTLLRAGAEADKRDSNGQLAIELSPDSKVRKYILETAEREGIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLT6</accession>
    <name>D4DLT6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000522">
        <property type="protein sequence ID" value="EFE37186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017831.1">
        <property type="nucleotide sequence ID" value="XM_003017785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLT6"/>
    <dbReference type="GeneID" id="9583727"/>
    <dbReference type="KEGG" id="tve:TRV_08160"/>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001278">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="41828" checksum="B4C3C9366EC16E6E" modified="2010-05-18" version="1">MTMVLEHGHRQYGGMGYDSGVYQNHVQSNPPQFNDAWSAQPSSHPPAPAYPSSIPPANPIKREEVQRPLPPALSMPYSSVPVSAPSMVPNGSYPAVTYGGSEMLVMPQEMPRTSLEQQPSSTTTSPIHQFPTASYGSIEYAHSLQQQQQQQQQQQQQQQQQQAHHQDHHQPPHHPHHPESRPLHPGSQPHTQGPPSSTFGDALDASRGMVALSQDLTPRGIYPPRASRGSADSYGFPSAHSSASSISSGNNYPYYSASVVSVDSSVTDYSSTTSESYDGLASRTLPRPSGLMGAMPPGPQSMMGQFSSKVPANTQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPYACDVEGCGRHFSVVSNLRRHKKVHKGEKDSGSPEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ85</accession>
    <name>D4CZ85_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025708.1">
        <property type="nucleotide sequence ID" value="XM_003025662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ85"/>
    <dbReference type="GeneID" id="9581951"/>
    <dbReference type="KEGG" id="tve:TRV_00122"/>
    <dbReference type="HOGENOM" id="CLU_092543_3_0_1"/>
    <dbReference type="OrthoDB" id="3262926at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="164" mass="18338" checksum="626A2B7622B6D7BE" modified="2010-05-18" version="1">MAEQTKSHIADPPTGLYFFYGTLMDPTLLVQLLHLDKLPDLRPASIKGYKFKLWGPYPALLDDEHDDSAVIEGAVYNVESVEHAHALANYETKNYTTGTTTAYYSDGQQPETDQVTIYVFAGNRRDLTEGDFNLERWMKMMGRGKVLDDLAAKKAGSAKKPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZJ6</accession>
    <name>D4CZJ6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-nucleotidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025598.1">
        <property type="nucleotide sequence ID" value="XM_003025552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZJ6"/>
    <dbReference type="GeneID" id="9581836"/>
    <dbReference type="KEGG" id="tve:TRV_00238"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF41">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005126465" evidence="3">
        <location>
            <begin position="19"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="442"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="707" mass="78063" checksum="390E494A1FC92D0A" modified="2010-05-18" version="1">MALFIFTVDHLLFRLLFECFILRLHDVRETIILEFSLTPVPSASTSNDDEETRKQDSDVGLFFYRLKRYCCTVIRSIGRHRLSVRSIKSTTKMADILTFYHFNDVYHISDASLISKFAHVFARARPDSKSSDIQPLTIFSGDVFSPSTESSVLKGEHMVPVLNHLDIGLACYGNHDFDFGESRLIELSGKTNFPWILSNVVHATPHKNPDSHVRDGSLLALAQEYVVKTMGQYKIGFIGLAGTDWPSNCQHLPPARFLSPAEVAHKLAVRLRTVEGCDFVIAATHMRLAEDLSVSNATLDGDGRIDLLLGGHDHDVVCRILGDTDDNPGAILQGITDSAARIRNGEIVHVEGNVRVVKSGTDWRSYSVVQLKVRKGGDSKAQLDNIEVTQYLDLTRMQTYPKIPKCSKTLSILGSVQNQIMDAVRHPLLHTCVPLDGRSAIIRSQETNLGNMLADAVRAFYDTDIAFINSGGVRCDRIIAETNGNNALKVKDIIGENCISSIISITMAHNLQCTDIMPFDNAFVVKRVGGATLLSALENSVSDSHTDGRFLQVSGMRFKASWQRPEGSRVLEAFFEPKAGELEEINPGRTYTVAMVSFIATGFDGYDCFKAEETLVDAESAMTDTSLMLQIFRHSRKSNSVESRVTNNAEENVEARSDAAGDDKTEMGVKRAMEAIITGYDDIDGLPIVSPAIDNRLTFVSTTGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0C0</accession>
    <name>D4D0C0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025335.1">
        <property type="nucleotide sequence ID" value="XM_003025289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0C0"/>
    <dbReference type="GeneID" id="9582946"/>
    <dbReference type="KEGG" id="tve:TRV_00515"/>
    <dbReference type="HOGENOM" id="CLU_1908213_0_0_1"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15006" checksum="4F537B55298880DD" modified="2010-05-18" version="1">MIAVGAVVITTSLQEREEEFEKKMRISFMKSTAMAPEANAVHGVSFKKRAPRAVKEIRAFAEQAMGTKDVRLDPQLNKKVWESGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKDPKGLQTTVIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0W3</accession>
    <name>D4D0W3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025130.1">
        <property type="nucleotide sequence ID" value="XM_003025084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0W3"/>
    <dbReference type="GeneID" id="9580623"/>
    <dbReference type="KEGG" id="tve:TRV_00709"/>
    <dbReference type="HOGENOM" id="CLU_894849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="311" mass="33647" checksum="D1B119DE9D6B83A3" modified="2010-05-18" version="1">MALNAGSRLTAHGLTSPSRPQETEKSNIPVQRTRGKHPNPTDSQRGAAPAQKRSSTPRRSLRAYPMKTTGDDDDAAAAGPGEAEAKLFAEGVGTNVEGLRAKQSSRRDAKTRTRYRGRQRTDGVGVGVGVGDGDGDGDGDGEPNDVNGGRWRLGAALELGDAAVHPSLAMALLPSRRAAGLAGWLPSYRCQHPAHSGLFFAVLRLSRVSSEYLVAEWRAEQVERRPPVLALFLGLGAALSLGDLTARIARFEKIGFWFFCLLSSLVTLSQFMQPDATAQPWSNRQRRLVSYRESSSSDDDLEDDDDDDVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D172</accession>
    <name>D4D172_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025015.1">
        <property type="nucleotide sequence ID" value="XM_003024969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D172"/>
    <dbReference type="GeneID" id="9580507"/>
    <dbReference type="KEGG" id="tve:TRV_00820"/>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="216"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="339" mass="38206" checksum="A0D241A7D6D0BF6D" modified="2010-05-18" version="1">MATTILRLARFSQRASFSRSTLAANTSQQRAMSLQSYVVTPKELHEALKENVPTKISSSPRVIPLCAAWFMPNDPEGRTGLMAFKKKRIPNARFFDIDVVKDTSSPYPHMLPSKEKFAEAMQSMGIRRDDRVVVYDTEEQGILSAPRVGWTLRVFGHPNVHVLNNFRMWVREGYPVEEGEVTPNEPSDYIVDEYHPNRVVLFEEMKEMGQDYGKEGSDAVQILDARPAGRWAGTDKEPRAGLSSGHMPGSQCIPLGEYLDPETKTLRSPDELRQLFESKGVDRNRPVITTCGSGVTAAVIDLALEQADYIPQENRRVYDGSWTEWASRVTEESGLIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D0</accession>
    <name>D4D1D0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024959.1">
        <property type="nucleotide sequence ID" value="XM_003024913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D0"/>
    <dbReference type="GeneID" id="9580451"/>
    <dbReference type="KEGG" id="tve:TRV_00880"/>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="288"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="510" mass="55243" checksum="705B003B880795E4" modified="2010-05-18" version="1">MALRQPIQRIAQLQRAQRDIFVTAAGPNLYTFDAQDGAQLDVWPAPAADQNSLPGENQPLAKAESTPDHAGTPPPEKKRKLSPTSSAAKDDTNAQKSSTTWTTIPLLLCTPSGEHVIAVTAEDKCLRVFAIGIDGTLKQQSERGMPKRPCALALAQNDSVILCGDKFGDVYSLPLLPDENAKPSAAVKTPAPAEELKAFKPSANPLTVHTKKNLYSLQQQLRSPAVKREKVGPSFELKLLLGHVSMLTDLAFVSFPAESRSYILSADRDEHIRVSRGLPQAHIIHGYCQGHTSFISKLCIPSWSPELLVSGGGDSYIIVWNWREGSILQRIPLQLTSQSSPAGIAVTGIRAVSFEGDTDLYQLAKGAILVSIEGSQEILSFSVKSDNTLEPLPSINASGNALDITNLNDKGTIVVSSDHVHEPGSTTQQRSSSTSPGMPLQQFTATVDSGGLRWEESHPSALSKINACSSFSLDLPGDEKERQKQLKHLRESLYHTGNLRKSVRGEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1G2</accession>
    <name>D4D1G2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024907.1">
        <property type="nucleotide sequence ID" value="XM_003024861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1G2"/>
    <dbReference type="GeneID" id="9580398"/>
    <dbReference type="KEGG" id="tve:TRV_00912"/>
    <dbReference type="HOGENOM" id="CLU_015750_2_2_1"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="205"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="443"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="593" mass="64801" checksum="2424046E963D6521" modified="2010-05-18" version="1">MAGTSTGGSLKRPHQLDDDGTSQKRSRSNNGSPAPPTPPPKVDMAKAIAEAKAKAEAVRARLNAQGTGGAASIPAAGPSAQQSGGSSPAMSRLEQMKARVAAATGKINISATKPPQPAPSFAPTPPPPANDDSMMRARGGLDVGLHPALLGDSGQDNRTTKGKQAMQPKFATTMANFRSESFTPPSRGKTPLDLSGPSIEETRNNPYFDPSFGSRSVAARPRHTRQLIFNQKGKYIQQAAALRRQAQLEAMKKRIAERARQAGIDEDLDVEKSYLVAAPPAIEWWDEGLVNGTDYIATDDPSNLKIDTPDSVITIYIQHPVLLEPPQDKNIPAPKPMYLTPKEQAKIRRQRRMADLKEQQAKIRLGLEPVPAPKVKKSNLMRVLGEDAVKDPTAVEARVNREIAERAQKHQDANEARKLTKEQRHEKLASKQELDAAKGVCVSVYRIDSLANGRHRFKINKNAEQHALTGICIMHPKLNIVIVEGGAHSINAYKKLMLNRIDWTENSGANSVREGNREALTSWLAAEDEKGELKDLSLNTCTLIWEGEEKNRAFRKWVGARVCETDGAAKDQLARAKMENFWALAKSIKPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K3</accession>
    <name>D4D1K3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024879.1">
        <property type="nucleotide sequence ID" value="XM_003024833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K3"/>
    <dbReference type="GeneID" id="9580370"/>
    <dbReference type="KEGG" id="tve:TRV_00954"/>
    <dbReference type="HOGENOM" id="CLU_089420_0_0_1"/>
    <dbReference type="OrthoDB" id="4172536at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055164" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="184" mass="20329" checksum="87B3B12FB73DB3EE" modified="2010-05-18" version="1">MTVITSIGRVALFALLAFESVVQASPIPYDIRGDVIISVPNVGHTLTSRSNTDSLPPELTDTKANVRVGYLKTVNRVPSKSHPPKGRRTEIPNPNGPRSEQTINRTRDYIEAKPVREQGNPTAVKVGKPRGKRDDKSTPRPSTPPPIQMAVDHVSPIPGGPWKHREETKSRETMKQRLDQGPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T2</accession>
    <name>D4D1T2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024795.1">
        <property type="nucleotide sequence ID" value="XM_003024749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T2"/>
    <dbReference type="GeneID" id="9580285"/>
    <dbReference type="KEGG" id="tve:TRV_01034"/>
    <dbReference type="HOGENOM" id="CLU_052538_0_0_1"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="32876" checksum="1980837A9A9321AF" modified="2010-05-18" version="1">MQWNSASEIATYLLSANPVAIVAACLVAFLLPLALHVFLYRTAPTSKSDQFILLGSSGSGKTALCAKLEKGTSSNLEPRPTHTSQVSSTFPVALHPAVRKGSDKYRYVNDPTLAQAAKQRVTFSLRDTPGHGKLRDLEVIAQLLDPSKQKQSKTKVRGVIFMIDASTLMDAGQLADIARYLYDVLIILHRFSASTRARSTPVLVAANKQDLFAAIPPAMVKEKLEAEIEAVRETRRKGVINPDAEGDDEADAFGSQPFTFQLLEEESGVKVDFLGGSVTTDYRDDATSGLRSWEEWMGQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D234</accession>
    <name>D4D234_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024673.1">
        <property type="nucleotide sequence ID" value="XM_003024627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D234"/>
    <dbReference type="GeneID" id="9582848"/>
    <dbReference type="KEGG" id="tve:TRV_01136"/>
    <dbReference type="HOGENOM" id="CLU_052682_0_0_1"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="310" mass="33280" checksum="FD94A18E27EE0C99" modified="2010-05-18" version="1">MSAAVSSSLGRAFTKRQKRPEVSAPMPFREGQPRFAAGTIKRSKISAPVELLSTTNLLAYTAPDIQKHGNQGHSHKNQPVISRPIIQRQHSNLQHSTSSSSSFRSADESDASNSLHTPSTTITSPSLPGSTEASPILRDNGHQNLTGYFDQQKDGPPKAPQASLEQSAPPPSIPTRALSHTKKSHQELSRQRSNSSNASAGRRTPSLSNTSSPNSTSLSSTHAAHSAAAAASSSSRSHAQDVHAHPFGKELEQVNEVAEEFSAGQLFRDEDEKTLAAKGLVKVDVVEYLEEVKGVYAYVFGGDVAKRDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D276</accession>
    <name>D4D276_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024661.1">
        <property type="nucleotide sequence ID" value="XM_003024615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D276"/>
    <dbReference type="GeneID" id="9582836"/>
    <dbReference type="KEGG" id="tve:TRV_01178"/>
    <dbReference type="HOGENOM" id="CLU_027962_0_0_1"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF8">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="11">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="645" mass="70886" checksum="09651272F99798B7" modified="2010-05-18" version="1">MEEPHTSTEQPEGTELPQHQSHEDTEMENESELVADEEMDDGDSRLQAAIHAQIDGDNSQAHQPPPGTGPEHSQTTGEAPSSALPSSTPHPSANGGPAGTQIQLPPVENWRPYVNPPNLGRVRQLLFEVKEPVELSLEEFNMYWPFIDNIWVKQRSTSTKDGLHITDYYMCRLRRPTCKRPPQRPLPDGKRPRNKVVREGGTCNFQIRVVKFEGAHTTITISRSPNSSSAHSHDLDYIDKVKKNSGVMEYVRQEAAQGYLPASIFAKLREDPQQLEAAGGKHLTTIDVRNVSGKWRSNHPGLTLRPHEGYAYQNGLGVYKVQDGQHINRPPAIIAHPRAMNLPANVLPFPTFPLDFLEPYLPKIGEDHNHGNDNSHSGETKFPHVTLTYAQSMDGKISTKPGVQTLLSGPDTKAMTHYLRSRHDAIIIGLGTALADDPGLNCRLEGAGGFGGFGTMWQPRPVIIDPTGRWSASAESRLLKTAAEGKGKAPWVIVSPGAELLPDKLMLLKRHGGDYLRIREYNPHWRLRWEAIFGALANQGIRSVMIEGGGVVLSELLNPEYVDFVDSVIVTVAPTYVGRNGVSASPDSKQDELGNPINALTPHNIKWQPLGKDVIMCGKIKTAPPPPPPPPILLGLEAAARADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H1</accession>
    <name>D4D2H1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BCAS2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024564.1">
        <property type="nucleotide sequence ID" value="XM_003024518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H1"/>
    <dbReference type="GeneID" id="9579888"/>
    <dbReference type="KEGG" id="tve:TRV_01276"/>
    <dbReference type="HOGENOM" id="CLU_082523_4_0_1"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22067" checksum="CA5F2E8A2968618A" modified="2010-05-18" version="1">MSLINETHDSLPYIDEDVTPQVRAELSRLIDAELPADYRSTLHPSLPELPPTKFSPLIEQELERKARNEPISGGIDLSRYEAPEIPPSPQTRTPTLPPKENLALLEAHGKNAWLIGNMQLEEILRRTEKELHDTTEATEAVNRERKLKQESVRGELAALEDTWRRGVSGTLDVEIAAEKLRRDILDMRRQQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V4</accession>
    <name>D4D2V4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024447.1">
        <property type="nucleotide sequence ID" value="XM_003024401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V4"/>
    <dbReference type="GeneID" id="9579669"/>
    <dbReference type="KEGG" id="tve:TRV_01410"/>
    <dbReference type="HOGENOM" id="CLU_1662078_0_0_1"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="159" mass="17398" checksum="411EFCBE325CEEDF" modified="2010-05-18" version="1">MAYKPRSPTDSSSFSSPGPSGSWPASYQPSDQGLASFKLPPILGRSSDIPPPKEVAQPRRFPSLPWLETEQRHHPTASDRIVSTSDSSNPLSPYRRGSVLSNSTHVSPTSPVSLPPLRTTGLQKAPADQLQTPIEDSQKEEDNRPAKRLRMELGEMVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I1</accession>
    <name>D4D3I1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024208.1">
        <property type="nucleotide sequence ID" value="XM_003024162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I1"/>
    <dbReference type="GeneID" id="9579246"/>
    <dbReference type="KEGG" id="tve:TRV_01641"/>
    <dbReference type="HOGENOM" id="CLU_070401_1_0_1"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="124"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="326" mass="36031" checksum="FBDF49838783244E" modified="2010-05-18" version="1">MLPFSRPWGQGLPILQATYNTTIRASAIPPFHTLSRRYYGGIVRAIVSKHVESISDTLSPVLPPNLRKRADHIKSESTYRANSSHIPNTNKTKPIELEDDVSTTESGRGLDAEMDIQTEVRRLMRLVPHPVAIVTSTDPNSPPSSAFRGMTVSSFNTVTLSPKPVISFNVKLPSETYNAIRFSSRFLVHLLSPTEAMARLALEFSKGYENVARNKDEQQASFFRFTAPSDVEASPSLQSGEPPRLVINGVKAGEDGRFPFIFECQCLPQTTRIGDHVVIFGTVVNVLSDQAVNLNTAHSARELCLSYADTRFWEMGDVILPSSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3T9</accession>
    <name>D4D3T9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000092">
        <property type="protein sequence ID" value="EFE43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024107.1">
        <property type="nucleotide sequence ID" value="XM_003024061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3T9"/>
    <dbReference type="GeneID" id="9577094"/>
    <dbReference type="KEGG" id="tve:TRV_01751"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="230" mass="25844" checksum="23F6EB5507DE359F" modified="2010-05-18" version="1" fragment="single">LNMVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVRHHCPGVPCLIVGTQTDLRDDQTIRDKLSKQRMQPVRKEDGDRMAKELGAVKYVECSALTQYKLKDVFDEVSQKICFYLLPFLLANSINLGHRCCFRAQSSKEVEPLSTLVDSTLPAQREGYSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D464</accession>
    <name>D4D464_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023937.1">
        <property type="nucleotide sequence ID" value="XM_003023891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D464"/>
    <dbReference type="GeneID" id="9582670"/>
    <dbReference type="KEGG" id="tve:TRV_01878"/>
    <dbReference type="HOGENOM" id="CLU_039063_0_0_1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="465" mass="50347" checksum="FDCB90ADBC47B61D" modified="2010-05-18" version="1">MAARRQAPEDPMATPLAVQPPIQATPTWPANPAIPGAPISQPPNTINTWTAPPEASPTSQYVPGAGMTSVVPILTSPAGTKHPKATEQYPPTTATYSPPTESLQPSHPPLHKKPQTTGFSTGILVGAIGGSIVGSTLLTLIAAYLFFGRRKSRGGNNLEGRQTREPLADKNYDLETACSPEHFSSNVPFAGNTDKTNTVGSLDLHAEKSGLGNYIPSPADDKTVESRILTVFDHLALHVENYYTSSSRSNSESEQLSQCVAMLSSYNSPFLPAPVVSLLSQSNDCEPIIKHCLVQSLIPATFHAAPSSASRSEVTSFLPPPFTAGRDFHEMQLQDQEESQVHFYWRMLTARSYRGVPDTQKQAYLSTRAENISQAVNAFTAAFRPFANPQHRESERIRHLTKVIEDAAELGIWLFEQPCGFQFIWSNLAAGQVVVSPAVVKVSDGHGKLLQTTKTIVKADTACYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D498</accession>
    <name>D4D498_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023971.1">
        <property type="nucleotide sequence ID" value="XM_003023925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D498"/>
    <dbReference type="GeneID" id="9582664"/>
    <dbReference type="KEGG" id="tve:TRV_01913"/>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="70"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="467" mass="51342" checksum="3BBD72CF1DFD34C2" modified="2010-05-18" version="1">MILSQQRLDQPAAKKKQQQAESQANERQGRDRREAEDEDEEEEEADEKTRRRSGHVDSTDYHLQGWHLRTRCAFSVHGRAGKVLTGRQTSVTPNAVKARPTPGYIYLYSEDDLVHFCWRPRSAPIDQPELDLVMVPSDGTFTPYKPTSAQRPSNPEQPTNGRIYVLKFASSSQRHLFWLQSRSQHEQGNPAWFSARDLKLGQIVNTLLQGEDIDVQDAIDSLPRGDGGNDGGDDDETMEDVEGTDHSPERRRHGGSGGAGPGATGGDIREEGQESREGGADGGRAFDVMPVTLFDFWLAAGSDPSSVVQNFLQSLQGNNNSQQETTESRYTTLADLLSTQSTLPFLESADESTLNQLLSSLPESLQLLSKQNNNAPVERISVDKKRNALRKVLRSPQFAQSLGSLTMAIRDGGLPSISDALKIPVQNGGFMRRGGVPLGGGEAVKAFVEGVRQQVEDNQKGDSMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H1</accession>
    <name>D4D4H1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023866.1">
        <property type="nucleotide sequence ID" value="XM_003023820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H1"/>
    <dbReference type="GeneID" id="9582477"/>
    <dbReference type="KEGG" id="tve:TRV_01988"/>
    <dbReference type="HOGENOM" id="CLU_033734_1_0_1"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32816" checksum="C8711E6E8763FD96" modified="2010-05-18" version="1">MVNLSEECKQLASPGAVSFTFSILIFLGILLSYLPQHYRIISRGTSFGISPYFILLGTTSGTFGFANILVLPKSARDIACCSDISGFACFAGLLGILQVGVQSLCFIIFLILFVVYFPRTPPTPTSTSATPEKSHNFRTALTVGAICLVHAIAVIILGFTVVFGYPSSRQMWANILGVSATILSSIQYFPQIYTTWRLRRVGSLSIQMMCIQTPGAIVWAISLAERLGMEGWSTWGVYVVTSMLQGTLLIMGVYFEYVNPQKPELEAGANKPTEPNGRSYGTMNGTDAQDDAISEDTPLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H9</accession>
    <name>D4D4H9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein tvp18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023874.1">
        <property type="nucleotide sequence ID" value="XM_003023828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H9"/>
    <dbReference type="GeneID" id="9582485"/>
    <dbReference type="KEGG" id="tve:TRV_01996"/>
    <dbReference type="HOGENOM" id="CLU_118698_0_0_1"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22429" checksum="CB3B6BE298074C7B" modified="2010-05-18" version="1">MTLAEEFRSRNFSKSIRRTSWPVPHMLTSSPPGIYAQWLATPTASSDSSLSSRGVLLVARPLYWKLTHYIYRTGILSMLICFAVGISNLFRVPSIILAFSIVCLACSPVILFIEVPLLLRICPTSSKFDAFIRRFASNTMRGVIYLAMSVIQWLSLVSKEATSLIAAAVFLLFTAIFYALAAAKGQEFTGSKTLGGQGVAQMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I9</accession>
    <name>D4D4I9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023809.1">
        <property type="nucleotide sequence ID" value="XM_003023763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I9"/>
    <dbReference type="GeneID" id="9582382"/>
    <dbReference type="KEGG" id="tve:TRV_02006"/>
    <dbReference type="HOGENOM" id="CLU_036368_5_1_1"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="478" mass="52350" checksum="E48466B381D424C8" modified="2010-05-18" version="1">MSERAPRGTRPSLRRSAVSHSFIHDHQQYKPAAASPPSYQPELGASISGTLEDPKVKESGIVHSLFGDALAALPADTPKLVATIFYVGDQSKNGSRSNNSNSNSNSNKNSSADLPTAEDPLEPAAPSLPLDALYGCHVSQLCLTSFIQMIESLSHPYRRMSSSHKCLDRQDNPRVVEVTITPPPSGEYLSFDELRKHESIWRFERTWNVEVVLQMENVWRRYKRLAVFDMDSTLIQQEVIDEIARVTGVEKEVSEITERAMNGELDFEASLKARVALLKGTSADVFDKLKSIITISPGARELCTALRKLGYKTAVLSGGFQPLADFLADQLGLDYAVANHVHLTLFVMLCAFAIRLVIDEATQTLTGTLSPDHPIVDAKQKRSLLRALALKNGIDMPQTLAVGDGANDLLMLKEAGLGVAWCAKSMVQLEAPTKLNGESLTDILYLLGLSEQEARSLIVSPSVDESSMKELTTTERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q9</accession>
    <name>D4D4Q9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-diacylglycerol-inositol 3-phosphatidyltransferase PIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023786.1">
        <property type="nucleotide sequence ID" value="XM_003023740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q9"/>
    <dbReference type="GeneID" id="9582359"/>
    <dbReference type="KEGG" id="tve:TRV_02075"/>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="316" mass="35108" checksum="BD2B02AC314F1684" modified="2010-05-18" version="1">MSARTRRQKAAQQAQAQAQAQGEDEHSDSLANGHSNGSKNGSAESPKMNGSARRKRSPPRDGQHSEKENIFLFWPNIIGYIRIVLATASLYYMPLHPRTCSALYSVSCLLDGLDGYAARVYNQSTTFGAVLDMVTDRCTTACLLVFLSSAWPRWAILFQGLISLDLTSHYMHMYATLTMGGSNQSHKKIDSSRSWILYQYYNNKAVLFTFCAMNEMFFIGLYLLSFSSPTLSPSLLQPSAVPVAHPTTLFANPWSAGALEMARANKMDSFWPWVLTGISAPIMAGKQFINIVQMVKASRWLAEGDIARRRKLGIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4X9</accession>
    <name>D4D4X9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000114">
        <property type="protein sequence ID" value="EFE43095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023713.1">
        <property type="nucleotide sequence ID" value="XM_003023667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4X9"/>
    <dbReference type="GeneID" id="9582261"/>
    <dbReference type="KEGG" id="tve:TRV_02146"/>
    <dbReference type="HOGENOM" id="CLU_105481_0_0_1"/>
    <dbReference type="OrthoDB" id="10533979at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="208" mass="23904" checksum="36798D23FF76FED1" modified="2010-05-18" version="1">MSSSALLNEICITVDSRDIITMPFATPYYMPLRKLEIEDDPDKTPTQTPRRMPPVLDFKPLDDDVDGDPRPRPDIKYMIAQGKHAELRALSYALGHGHHEDYAFDNEDLDALVAWEEEEEPLAYKEYRALPVYHEADAVNEWKEEERRKRKEEKAKRKKAALESSTTGWLSTKALLGLSVASLSVALMLWMIFWVTADNHMLVLVLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5R6</accession>
    <name>D4D5R6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000128">
        <property type="protein sequence ID" value="EFE42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023424.1">
        <property type="nucleotide sequence ID" value="XM_003023378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5R6"/>
    <dbReference type="GeneID" id="9583445"/>
    <dbReference type="KEGG" id="tve:TRV_02439"/>
    <dbReference type="HOGENOM" id="CLU_1647844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="17918" checksum="62792BF2A52E211B" modified="2010-05-18" version="1" fragment="single">PNSKRQVWLSSSEKQSHGGQTGSPLRRICQLYLHCCAVAAAAAAANDDDDDDDDVVVEAEWMSFGHLRPSWEEKAAALRVLLMTKQSNQSLYYADSAQAKSGADQPTSNALTAFGNPLLAFFFFFEFLFFDTFFIRSNVFPSRTPTHDGHCDRVACDILRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D611</accession>
    <name>D4D611_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amid-like NADH oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023308.1">
        <property type="nucleotide sequence ID" value="XM_003023262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D611"/>
    <dbReference type="GeneID" id="9583350"/>
    <dbReference type="KEGG" id="tve:TRV_02534"/>
    <dbReference type="HOGENOM" id="CLU_019845_0_0_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF5">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="46652" checksum="325B7F2311FC673E" modified="2010-05-18" version="1">MLSESLKFYGKGSRAMLSIGLARMYQHIQAIGHRWLYQATPSPKNVVVLGGSYAGIHLAQRLTETLPTGYRAVLIEKNSHFNHLYVFPRFGVVPGMEQSAFIPYTGIASHAPAGIFQHVQDSATSVTGNTIELASGKSINYEYLAIATGSHQPPPARMKSKDKEDACAEMRVIQKQVQNAKRIAVIGGGPVGVQVATDIKSFFPAKNVTLIHSRHQLLPNFGPRLHGHILQRLDRLNIKSILGERPQSTTEAVDGTAPISQELSLRFKNGSEEIYDLVIWCSGQLPNSSILSKCFPSAICKETGQILVHPTLQVNNSPGIGNKHIFALGDVAKTDGPRMGRACQSQAEIVASNILTLIKSQDQLVTYRPSIVDRVIKLTLGKNDYVWYVKDDNGRELMLTGKGGGTDLSVGQAWSKLRVSPRDITGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E9</accession>
    <name>D4D6E9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023211.1">
        <property type="nucleotide sequence ID" value="XM_003023165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E9"/>
    <dbReference type="GeneID" id="9583231"/>
    <dbReference type="KEGG" id="tve:TRV_02674"/>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114719" checksum="4273DF943216C01C" modified="2010-05-18" version="1">MDQELIRLLSDTQSAAAETRKAAEVRLQSLYSNESFPLSLASIASHSSVPAPLRQSALVLLRTFINSAWSSQLDDFKGQVLVSDANKAHLRRVLLDLATSPEQDDRKVKNSASLVVSRIASADFPEDWPEILPTLLQIIPNSTDAQLHGALKVLSDLVETGFNEEQFFKVARELVSTVFNVATNASRKPVLRALAVSTFRACLDTLEMVLEQHKNEVKQFMDEALNGWLPFFIATIKEPLPPMPSEEEEATDAPGPQQWRGVIALKSQVVKTIMKVRSVLPSLLTTQSTTLFHTIWTELTTIQDAYQQLYIQDERQGRLEDADNLPYTLDFLVLEELDLMQALLRAPPVRIELENQLKLAGATSSTSWLPEMMKLVISYAQITTEEEGLWDIDVNLYLSEETSVTANYTPRTCGGDLVIRLGEWLKRTVVDGLLAYTNVLFSDPSTGWKYREAALFILNQLLRDLNDVDQTISADLATSFNEFVKFCIQRDEVFLRSRGYLVAGAIAQTAGEGFHQSAVPYLEAAIQAIRNDPSEVVKVSCVRVLQDFLPALPQATAAPFQVPVLSILADFISSHDLRDFSEGDDLKFTLADTLRDTIMVDANIVLTSTALDVLFNIASAGAGNFQLAMIVTETFEQIVEHIAGQGPDAYISLCEKVLPPLTGALDVGNLTQENSLTNLATDLLRALAQNGLKPLPQGLVATVLPKLNRLLLGSGDSELLPSATLAVIHMLERDPDQFLAWQDPQTGKGAVETVLIIIDRLLGEAVDDNAASEVGELAAELVEKAGSEKLGPYLPQLLRAVAQRLATAEKAQLIQSLILVFARLSLVNTSEVIDFLAQLDINGQSGLQVVLAKWLENSVTFAGYDEIRQNVIALSKLYQLDDPRIAEIQVKGELIIQDTGRIKTRSQSRKNPDRYTVISAPLKIIKVLIEELSSASGGRDIRGAAGLSGSQLDELESDDENDDWEDLPSNNNFLDLGLGVTKQELMGFAAEDDDGALASRQRDDETQAFLTQFFAETASTPRFQQIFASLTPTEQGRLQSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6G0</accession>
    <name>D4D6G0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor Prf, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023163.1">
        <property type="nucleotide sequence ID" value="XM_003023117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6G0"/>
    <dbReference type="GeneID" id="9583183"/>
    <dbReference type="KEGG" id="tve:TRV_02685"/>
    <dbReference type="HOGENOM" id="CLU_011017_0_2_1"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="889" mass="98323" checksum="57DBBA20E3C8600A" modified="2010-05-18" version="1">MAGGNEQTGAAVAESAAPTRTRAESPGAQEGNPGYIPRPKRIACVVCRKRKLRCDGAKPSCGNCSRLGHDCAYNEVRKKSGPKRGYVKHLEARLAQVETLLKGVDTAESSRPSPPTRAFDSQNAPFQGRPNMFPIRTAVPKSVEADPNLSLDGMDMFGDMGDILPPPATLPTSNSASSREFSWEMIGLGLEEPLPSQEVIDELDEIYFEKIHPSSPMIHKPRYYAAMNLAPSMRPPICLRYIMWAHAAAATDKYADIHTHFYARARKYAELDQMKGLGENIISVAHAQCWLLIGCYEFKMMYFPRAWMSTGSGMRLCLMLGLNRQDARGLDVKQALPPARDWTEREERRRTFWAAFCQDRYASAGTGWPMSVDERDILTNLPASEEAFVNSVEQPTSSLAETISGQETSSLSPYAATVLLACMFGRNLHHLHRVTTNDRDHDLNGEFWKRHRALDNILLHTSLSLPNHLRLPEGINNSEIVFGNMCIHASTICLHQAAIYKAEKHSMPGQISTESKRRCIIAADQITHIMKMVSHMDLAKMNPFLVFCLYVAARVFVQYLKSRPQDQAVRSSLQFLLSAMNALKRKIPLAESFLVQLDVDLEGSGLMTDDGVSRFSYSSVHRSPEDDARQAALRAVRSQFEKCAIGIIDIALLDKQNQDPKTSSKSPATTSSSDPPGVSSQGHPKPRGQQFPAQSQVYGLGMPGNIPNIGIPQAHDDHFRFMDFEIDASAGGTSTGGSERHPSCSDNPSPNTNKTSSNSSFSPAHLDQPSPNQGGMHNQKPLPQHLPSSLPYTTNSAFGASMQNPNKTNTTPLPRDFAVTASEAQFQQELFNLPEGWDFMQQQQQSQPNEPDLIPPTPTSSTMEAVLSSLEDIPWSHSPETFNTNQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6I8</accession>
    <name>D4D6I8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023135.1">
        <property type="nucleotide sequence ID" value="XM_003023089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6I8"/>
    <dbReference type="GeneID" id="9583170"/>
    <dbReference type="KEGG" id="tve:TRV_02713"/>
    <dbReference type="HOGENOM" id="CLU_008344_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126417" checksum="BE0F8B2F2320B6BD" modified="2010-05-18" version="1">MIAVSRPADQISVHKNQQKGPNPDVPPPKTDKPRPHVCVTCTRSFARLEHLKRHERSHTKEKPFECPDCTRCFARRDLLLRHQQKLHMATTPASRPRNVRRESMSSSTRVRKNSIVGSSNTMRPRANTISHVEGAAVGMFASTNAASRPAQPGHTHHPSLGGLPNLPNFDYRSGISSLNGLSKLDTAALTNEYPDALRTAPVYGSFDVPFGMGDAMMGQGSTINPAQLHFAGSPHGFADSPASPFSHNFSNMTATQSTLEDDLKFEWLNGLDNAVTFAPNDSAIDGSSPSAMSTGSQSGLSEAILDAANQAATTSAGSTTWPATLQSQAQSQSQQYALDFASLTFPEFAAPPDTVSPKSLLSHGHASNNSFSTSTSLASMNGPVLSGAPTSTFHISSVSGTNGLQSFGSGYKQTSQPAYLSSITDSTRQALMGTLQQPSGFNNRRFSQHSLSASPMSPSSPGSMLGNSQHVCNLPSTYDLQRYVSAYVTYFHPHLPFLHIPTLDFTALEYSGKPISSGTAGNIALGGGCLILSMAAIGALYEYDSATSKELFESAKKMIQLYLEERRRADMSAAINRSNYNRDNSLHNTPLWLVQAMLLNVIYGHNCDDKTAVDIASTHCAALISLARAAELTQYHPPESLPADQLGYDSSSSDLLDPNMETWMRQHTEVSNERKEWLKWKIVEERKRTLYAIFTLSSLLVSTYNHSPALTNSEIRLTLPCEEQLWAAESPEAWKAMGGAENTLIEFSTALKSLLAAGQTPSQNQYGSTIQADGSLSSELRPSTFGCLILIHALHNYVWETRQLHLGKQWSNQETEAMHVHIEPAIRAWQRAWSSNPTHSLERPNPFGAGPLSADSIPLLDLAYVRLYVNLGRSKEAFWQRDWSNMADELTKAVQSVSLSNSNPESEFSLSTNDDAISAQMLESLADYGVADLTISCSSNDDLSLLASGGQNNMQASRSERLLRKAAFYAADSISMSNEWGNTFAEFTSRDLPIQNAICLFDSAQVLAEWATAVQERIGPFLGILGQDHVDFNEVPATVLLEEEDRNLMRKIQDILNNVENKMKNMMSHLGTTGSESWNHLPSLVEGGYGTKIVLSAAFLLNKAGVWPADVQCTRSSRPEDEIESSEFLFWIGIGIHIFHSMSCKMIPVGRFTFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6S0</accession>
    <name>D4D6S0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023107.1">
        <property type="nucleotide sequence ID" value="XM_003023061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6S0"/>
    <dbReference type="GeneID" id="9583127"/>
    <dbReference type="KEGG" id="tve:TRV_02797"/>
    <dbReference type="HOGENOM" id="CLU_2564825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="82" mass="9456" checksum="DEF5BDBFE66D5809" modified="2010-05-18" version="1" fragment="single">FQKVEMVIKPVAKVVIPDFSVFHGEIECQDLFPISTSFFVFVQFEATSSPATQVGYTWDDIGEYLAIELGHFKHYELHRQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6T5</accession>
    <name>D4D6T5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023065.1">
        <property type="nucleotide sequence ID" value="XM_003023019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6T5"/>
    <dbReference type="GeneID" id="9583085"/>
    <dbReference type="KEGG" id="tve:TRV_02812"/>
    <dbReference type="HOGENOM" id="CLU_046496_0_0_1"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="369" mass="40706" checksum="9AF4A43CCBDBFFFE" modified="2010-05-18" version="1">MATLAMQSLGCEVAALNTVHFSNHTGYRQFKGTKSSAQEITNLYEGLRQSYLTDFDVLLTGYAPSATAVEAVGAIAMDLKKKASKKPGSFFWVTSNRRELVLDPVMGDQGRIYVNEDVVPAYKALVPHADLILPNQFEAELLSGIKITSAENLVDAVTVIHRTYNVPHVIVTSVQLPGLPSSSASSVISLSTADNSSVSQDARPDNTLAVFGSTMRSDRSARLFKVEVPRLDCFFSGTGDMFGALMVGRLREAVFNDSPALRETASWVSPDNVATTDLPLAKATEKVLASMHTVLEKTMIARNEELARYQNEDERNDAEFAHLPEEERKAALEKRARLRASKAAEVRLVRNVEHVRHPVVKFKVREWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D771</accession>
    <name>D4D771_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022963.1">
        <property type="nucleotide sequence ID" value="XM_003022917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582982"/>
    <dbReference type="KEGG" id="tve:TRV_02951"/>
    <dbReference type="HOGENOM" id="CLU_003025_0_0_1"/>
    <dbReference type="OrthoDB" id="5382102at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1690" mass="184107" checksum="FC714FA288A77EEC" modified="2010-05-18" version="1">MGVDTRRPILPAPTESVLDTTVASTTGTATDLATDLSRRTDKTSYSIPEDGSPITISTRRRSSRPRDRDRDREEGGGGGGGGGGKMSRSSHHSQTSLLIEYFEGGKKGSGSGGISSRPSVRVRVTPSSSRKTRDRDRDRDRDRDRDRIHISENSGGRRPSYTRRISLSTPTRSSKDAGGRVGAAGAGADDDGSLSSLTDGADDIGASRGHPVEIEIVNRDSEVSSRYIQPTSDISSMPADSMLDRPLVLSETHTNRPRSHSLSGDETEPASDSRDLLKTPSRRRSRSLSRERIAQKAAEKISGGAGAGAGSGSRDRTRSKHRYGEGSSSGGLDYSSKRSGKDREREMVSPESSYLSTSLASGNNGKTGNGDQYSFRSGTSRSSLNNPKLLETVEDAIRRLILPELKELKKDQKDDPLARIKAGRGAAGAGTAAHKSSKEDVAASSKLAKRFSAPDVSRSLGLDAERNNTSSPVRSPDSHSSSRSKERRREKRASPGRERSSSRQDHLSVEAPGVSRKKSKGLRDAEAAKIVGTALTTAALKHHDSNSSLGRRDRVHKRSKSSLASGSRGAGAGTAPGYNDTELIFQKHDVAPMPFRSGIDSDMTRQSILSQQSAQTATALEGEVSRGSPRALASPIGRMTPDDSGNQHARDLGSGLSEEITREYNESPTPKALEPQHHHDLDLDFSNNRALSPIQSVASYQADEHHNRSLTPGQEGDEASKQPQRLSIESLSSAASTDLARSTRTADYSHRHPPTIPDEELGSKLDIGESQRNSPSYWDHDEHEHHHDHDHDLDHDRDIDIDSKHMTNYTDDTFTDPLDQGQQIAGCRATNVQYVHTPVGVESAVASLLDPSQVSTRSPHPLVNRSSRSYTPGMEGDEGEGEGEGPSRHLDLNEEDEHEAEEDQHEHDHVEEEEEPYEDEEEDADVDHQHEDDRAVDDDEPAGPPSVDERPFHERMGVTSPPHSTAQSEEDEEDEEEDRPILGANALPNSGSPIPEIGHMVDTESDINTNPSIIQGPIGGVPHEGRDHWPYEPSPPQSGRQLLSPERELNDADLPGADYGAAGGLGVISEEPGRDRFDLDKGLGPNPYGNDHFDMASPNPRDEGYISGANHRSNSSATPEPKGKGFDLSNDIVGGLGSPMEVDDPFNDKHKRHLSGYSHGMPSPLYDSSTGRGIDRIQSKDIVALMDHLTVRDAQRNARDTEILITLVRSAAEMRNSFEDMKKYIAQQDEMLLDANSKGHDRTQKAIGGPRPMITPRTHSKMSSEFEEEMRSKKKNVFKRALKTLSLKSSGDLTNIEEMLLHLLTEVEALRAAQEGRAPVMGTSAENINGNGQGNADGYDDHDRSGATTAEQSPYNSSPLRADVRVQSSQRNISPVMEENEEEPLTRDEQEILENPTPPGSRFVGRHKRGASVPLATPERVPVASPPSADTTPKMSNEKSRKTKSSSSSFFPKISRWSRTTASSMGENIRNSIQPNRKERLSSDASRSNSDLENANYTTAEYYDHRGDDRLRSTTSVNKDAAGTENRPPSPLVPSQVSEIPKYRAHRDSLNLQHPQPRQGPTSRYQTQLESQAQHYGVPTSPNSDAWASNPTLGALNRDRPSSAADNHRPMSAGAYSVGSSIMSQSGPARPPKIRDDGPLIPQRSSKLSDDPNPSYAERMAMREGTARMVDHVVSPNPISNRLNSNAFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D783</accession>
    <name>D4D783_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022915.1">
        <property type="nucleotide sequence ID" value="XM_003022869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D783"/>
    <dbReference type="GeneID" id="9576953"/>
    <dbReference type="KEGG" id="tve:TRV_02963"/>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="219"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="575" mass="64354" checksum="932AEC51263CE83E" modified="2010-05-18" version="1">MILSYRHRQDFLISKILKRREEEEEEEEKELEQVLLEEIDSMVKLGKSSKRTPVRLRHKIEKASAAKQRKDRKLAKKNPQWRSKLKKDPGIPNLFPYKDRLLQEIEEKRRIKAEEAQKLREEAKLRRQAQNVEEAGDVDITENADLIDDEDDELIESDDDDMEVEGEESNPMAALLASAKARAAEYEDQHGDEDMVDDEEDGGVTFEDTVIPTTKESSRRAFDKAFKEVIDRADVILYVLDARDPEGTRSKEVEREIMAADHGSKRLILILNKIDLVPPPVLKGWLVYLRRYFPTLPLRASSGAPNAHTFDHKQLTVKGTSETLFKALKAYAHDKQLKRAVSVGVIGYPNVGKSSVINSLTSRVTRGNANVCPVGAEAGVTTSLREVKLDSKLKVIDSPGIVFPNAEKPKSSESRKIKEQARLILLNAIPPKQISDPVPAVTLLLKRLSASEGLLSKMLDFYGIPPLFPTNGDKTTDFLIQVARRRGRLGRGGTPNINSAATTVITDWRDGRIQGWLEAPALPVSTAVEDDAAGESSGPAADTKQIVTEWAKEFKLEGLWGDDAVPEDNDEQMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7A9</accession>
    <name>D4D7A9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000154">
        <property type="protein sequence ID" value="EFE42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022875.1">
        <property type="nucleotide sequence ID" value="XM_003022829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7A9"/>
    <dbReference type="GeneID" id="9576912"/>
    <dbReference type="KEGG" id="tve:TRV_02990"/>
    <dbReference type="HOGENOM" id="CLU_806484_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36773" checksum="33675159F87CB393" modified="2010-05-18" version="1">MSQYHSVANEEPVDGIPHVMETSRAASPSLSSNLEDTVVGSDQCSSSGSDSLTGINTPSNDESTGMASRSASPASPRAHTVSASSREGATFAHSIDAAERAQSEARPEGIHRLTKESSGIFFTRFLFLLGLTFLAGMIVGSWPHHECKSRYPDIVYSPARAMQEYRAVRFDGDIQTINPYKGPPSKALDEAWKALYDVGPLLVDKKELEAIGKESMELPSRPGKHLAKLAVFHQLHCLDYVRRYVHREHYRIDDSHATVSGIDHAGSVMFSGPHAHHLQSEESFAEVEADFSATHACTNFEKVHGWAKDQAINMTEEIIRSPRPFRDAVVASLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L4</accession>
    <name>D4D7L4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022800.1">
        <property type="nucleotide sequence ID" value="XM_003022754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L4"/>
    <dbReference type="GeneID" id="9581477"/>
    <dbReference type="KEGG" id="tve:TRV_03097"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPAF-like PDZ" evidence="2">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="1">
        <location>
            <begin position="352"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="673" mass="73972" checksum="324FFB1BC85F667C" modified="2010-05-18" version="1" fragment="single">RQEPCALIAKAQEEQRKKDPYARALLIEAGLAHACLTSVPIKKSHALKLIDGLFPFLEWQSTIDYLKNPPKGYQLPGVDVVGGLKKIRDKVSRGEYPNEYSFQNELTALIASAYDGHFYVDLDLMSVFKLGRPDIGPLVSVSQDGVKLPEVYVFSDLNATVKEGAKWKPSAVTQIDGEDAVDWLQKWSHHGGQRDLDSLYSGLFYSIPKIEQGWYGSFYSALGAYPGDNTTLTFENGTTRSFVNRASTREVWAGVKDGESFYHQFCNDDDAEERRKRRDNRHSAITTISQREVHFEKRDEPGKSPRPLFPKAVEEFGTGAVAGYFLDGRNDAAVLSITSLLAEDKSGGLHFQQYSAVVSRFLADCAKAKKSKLIIDVTGNGGGTVFMGYDVFKQLFPKNDPNDASNLRATDQLDFVGKKVNKALSDGSGGKQAESRRGKEFDASVFMDIHGRPRKNWKEFFGPDEVSGFKFTNLSTWDLGNKDVAGFAGQTTVAGYLDRANLPPPVFQPAQMVLLTDGACGSTCALMADLLRRNGVKSVVIGGRPRHAGRVEAVGGVKGTQTLTMSQIRSVAILTVDDLSSEKEQERLAKTPIGKVARNGDDALARIKEGGVNFRNAVHPDDSSKTPLQFVSEPADCRLWTTTPMLFDMNEVWRTVYDAAWGDGSSCTPGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D843</accession>
    <name>D4D843_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenazine biosynthesis-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022621.1">
        <property type="nucleotide sequence ID" value="XM_003022575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D843"/>
    <dbReference type="GeneID" id="9581280"/>
    <dbReference type="KEGG" id="tve:TRV_03278"/>
    <dbReference type="HOGENOM" id="CLU_048756_1_1_1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33472" checksum="326DAE273C2AAE91" modified="2010-05-18" version="1">MQIAIEFGYNNTAFLHEPVYLEKIGKNVRKLELFGATKAHKPLAFEAILGVALYIFQENPLDSTTPVPAPRGGTEAEKSASAAFLECFIQYNELVFRAEYDPLRQVGVLLMPHNVHIHGRETRKDEILAIQPSLSNVEDVKKMKASYPILSIATGVTYTLVDFTNSPNLLNLLEAGEPPTPELDTSWKQRAVDESVVSRHYGAVYFVQDEADFTEEPYITSLQVRVIQDGVEQTATAGACSTLAAYLALQKGGNNSSHAFAMKQTTTTGRSSQLCLQIGLDENGTSVKRIVLSGRCTLISQGTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D869</accession>
    <name>D4D869_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000170">
        <property type="protein sequence ID" value="EFE41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022566.1">
        <property type="nucleotide sequence ID" value="XM_003022520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D869"/>
    <dbReference type="GeneID" id="9581224"/>
    <dbReference type="KEGG" id="tve:TRV_03305"/>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="274"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="465"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="694"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="107465" checksum="BBF46A2D6BD5CAB3" modified="2010-05-18" version="1">MAPKFKDGDTVFSFNGKWISWSHTVVGYAAFLGALVVGLWLHYHKIVQNEHYGYPDEWFPSVSATIGDRYPERSVFQIFIAITSGPRFALVFLWYILTARPNSVLPKAVLGVGIFRTLTCGGWTYVTSTDDHGWHDIFMIAYLVATLPWTLGCLALSPPNPRALKYRRMFAGLFFATLVPLVYFFIQHKVHKIPGAYTTYAFFEWALILFDVAFDAVTALDFEGFEITVKDIKGISRGTSKSDAAIEKEHGVPLGERFFLIEIFDAAADIYNGFVFWSTLTSLGVVVWCKLIITITRGFELTPYLDFPLWNMGISGYEAFVMVSISPLLLAMPAFRSFAVRNVKLLHLLSLSGLLAYQVQYPSYRLFLVGFSVAMGCLTWAAIFYGERSQPGRLETRVTAWTVGLLASSLMKYACHTNNPAWPIVNEKNGGWNKTVLVLALIAMLRPSRRNYVSGDYMTSSNGRKGSSFLSALGFGGLTFAMHSLLSDSSTMILWVWEGFPVRGPIAVPHGSLTLLAMAAGVYLGVTYPRLAGSWTAFGLGSVGAALLTGNSHWLGFYGGLILAVYVMAVAPVLISSGVKHSPATVFGLGFFVYNFMVLFHVWIVAYAFVPGGPLVRERTDWVMTSMMLLIGAGVFSSSVSQTTSSAKYRKPVVNARKQRTYYFYVLGALQIFSFAVGFMRFPTNDYTPYHKDEKVMTAGIWTVHFSLDNDMWSSERRMRDAIKELELDVVGLLESDLQRIIMGNRDTTQFLAEDLGMYVDYGPGPNKHTWGCALLSKFPILNSTHHLLPSPVGELAPAIHATLDMYGEQVDVVVFHSGQEEDPEDRRLQSEYLSKLMGSSNRPMILLSYLVTKPLEGNYNTYVSEQSGMKDIDPTDWDRWCEYILYKNIRKIGYARVSRGTITDTELQVGKFAVGQPEGKGERISEDQVPVGMRFPAMFRGEGVRGHRYHVFDEPRYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q5</accession>
    <name>D4D8Q5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endosomal SPRY domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022428.1">
        <property type="nucleotide sequence ID" value="XM_003022382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q5"/>
    <dbReference type="GeneID" id="9580975"/>
    <dbReference type="KEGG" id="tve:TRV_03492"/>
    <dbReference type="HOGENOM" id="CLU_038401_1_0_1"/>
    <dbReference type="OrthoDB" id="5393404at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50286" checksum="75EA8E15FBACC3F6" modified="2010-05-18" version="1">MAPAPVVAPSDEGALSPGSSSVVAEFLKSIKRTTPSNIKDFLEPRNMPTKSLETNMEGTKILAARDKEPTTPLPVYGEGAIDPHSINMQGMLALFALLGAALVIAAIWFFFWAKNGGFIWRENDWDDYKSTVLRRKGPDGRTLSNATKSTALGGGSIVAREYRDYDDATTAMETETVATGKTGRTRRGFIAMKKKLLRRQKESDWEGGHDEDMRAYRHEKPAQVGGMNREADGTYHGSDFTPTNTHTNTHNAGSEAGYTYTYDEKSQWTQSQAGYTNKYEEMDISRGRNASGFSFVAGEDTVSHATEEQRPLREPSPPPRRRDTDHRRTAGSRTDASRTEASRSDVSRSEASRSEVSDTERRSRHARHSQRPRGPRTSTSNNRQSTSRKRTSMPGSYTEPLDMSEYSYQHLDGSDNGTSNMSYHQPLPALSKGYRRTGRGRRRDSLSDSDGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8U6</accession>
    <name>CTSD_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable aspartic-type endopeptidase CTSD</fullName>
            <ecNumber>3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CTSD</name>
        <name type="ORF">TRV_03534</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022323.1">
        <property type="nucleotide sequence ID" value="XM_003022277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8U6"/>
    <dbReference type="SMR" id="D4D8U6"/>
    <dbReference type="MEROPS" id="A01.077"/>
    <dbReference type="GlyCosmos" id="D4D8U6">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9580870"/>
    <dbReference type="KEGG" id="tve:TRV_03534"/>
    <dbReference type="HOGENOM" id="CLU_013253_10_1_1"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397700" description="Probable aspartic-type endopeptidase CTSD">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397701" description="Removed in mature form" evidence="2">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="102"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="2">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="509" mass="54631" checksum="2EA12E9D2B261853" modified="2010-05-18" version="1" precursor="true">MQFLWLCLLSAVTLQFTGTLAFYPIKLPDFTKGLVSNHGSIDRRFFTFPGLYKHAHTGSTTLNIRRGPSNYRRDNNYPAQIASPPTAPNTLGINNDGYDFSYFSEVKVGSEGQKMWMLIDTGASGTWVFGSDCTSKACGRHNTFGKEDSKTIKVTDEKWGVTYGTGKVSGVIVNDTMSFAGFELVTPFGSASTASDDFLNYPMDGILGIGPQDPNAKTPTVVQLLMQQKLLKSNVIGINLQRASEGATDGQITFGDIDKSKFSGELIYSNVVPDGYQWEIAMDDLIMDGKSLNLKGRTGIIDTGTSFLILPPADADLIHSMIPQANKGSGFYTLPCSTKVDIKLSIGGVEYTIQPDDYVGNETATKGTCNSLIVGRQILGPKQWLVGDVFLKNVYSVFDFDKNRVGLAARKYAGTKNPPSSTPSPGMFLLHAILCPKTISVLMLHIDPTSNKAPSGGSPGLPAESGSDSTTNGEATNGATSSPNSSSSVLTPTWLTLAVFFAIGSSLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V7</accession>
    <name>D4D8V7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RAD52 DNA repair protein RADC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022334.1">
        <property type="nucleotide sequence ID" value="XM_003022288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V7"/>
    <dbReference type="GeneID" id="9580881"/>
    <dbReference type="KEGG" id="tve:TRV_03545"/>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="544" mass="58510" checksum="0535DDC912E478B4" modified="2010-05-18" version="1">MPAIGDQHRLGPGDNPAISANPYLKGTGRVEEFTPTEVASLRERLNKQLGPEFLSSRPSGGGKVHYITADKCINLANEVFGFNGWSSSIQNITQDFADENPTTGYGHIENCKGKAAAFEKAKKEGTTDALKRTLRTFGNVLGNCIYDKEYLSKVVKIKAAPVKFDVDNLHRHVDFVPPKVPTAAPTNRIIKQEYQNNGPSNLPARVPDIENITAEDSLAYEFEGEFGKEPDYSRRSTGQNGPSATHPPTDARNFANASKVATTVDTRKPIASVSANGTVPSHNGQADGINRNNMMGPKTPVPGRFAQDKNNDSRHPSGRQTMQPNGPPFPHPNDQGRPKHDPAPNNDGNKASGAQSSEDKVSEDHVVGFFSARAAEALINDPHTAVKSAPVFDPQFDSPSIRKTAGIDHTSSSPIVRKSLQALQQQAGKVPLPGAKANAPTPNSGHGPIGRPPMTSSYRPPIRRSMGAVSTGNASTASNMPPPVRNHNSPINGGQQQNEYGKRLPLVDTTNVPNNERTKNQADAAKRTRVEDANAPKQNLQGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D967</accession>
    <name>D4D967_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022254.1">
        <property type="nucleotide sequence ID" value="XM_003022208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D967"/>
    <dbReference type="GeneID" id="9576856"/>
    <dbReference type="KEGG" id="tve:TRV_03657"/>
    <dbReference type="HOGENOM" id="CLU_074390_0_1_1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25109" checksum="5B52A655315B66EB" modified="2010-05-18" version="1">MHPPSTLLLRSLRSSISKSISTSSQPSYASLQPKISRCLLKPTPAGVRTYTSDKSNPDPNVRAQPRPRRTTLSSADMKPKSNYRGPPPEGTDAQHMTDLNSLNILSGAAVPATAIDACHHDGFQLNNGVRIADGNGCLLVDGEAFVWKPWEAAAGKERSFINEKGQWEVPEGAWGALRLLWPKPGMQLRSSICWQQREAFKKLQPPCYRLDREVGLLLRTLGGHISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9F2</accession>
    <name>D4D9F2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022140.1">
        <property type="nucleotide sequence ID" value="XM_003022094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9F2"/>
    <dbReference type="GeneID" id="9579037"/>
    <dbReference type="KEGG" id="tve:TRV_03743"/>
    <dbReference type="HOGENOM" id="CLU_2135342_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="113" mass="12826" checksum="E2CA39D3ECA79258" modified="2010-05-18" version="1">MKLSIFPFLTSDEFSQACREFIRLVDGCDGQLEPLGWTKARFDETGAEPVLVVRKYTDRDSQPTESTETEPGVGEKNANIKDEEEDIEEKEDDPVRQILCIQQPSLITSILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9G1</accession>
    <name>D4D9G1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022149.1">
        <property type="nucleotide sequence ID" value="XM_003022103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9G1"/>
    <dbReference type="GeneID" id="9579020"/>
    <dbReference type="KEGG" id="tve:TRV_03752"/>
    <dbReference type="HOGENOM" id="CLU_1895660_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="14116" checksum="DB6ED91EA5C4C52D" modified="2010-05-18" version="1">MSTQTPTEQAPEPAPQAAPQAAPAAPTPAAAKVEAAAAAWKAAAEEWNAAANEWLAVSEAGGATEAAKVAIETMEAATKSIAAARAAAAALANCPAPAAPARPRRHRPHQVAKMRARRAERRRLEREIKKEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9W0</accession>
    <name>D4D9W0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021955.1">
        <property type="nucleotide sequence ID" value="XM_003021909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9W0"/>
    <dbReference type="GeneID" id="9578865"/>
    <dbReference type="KEGG" id="tve:TRV_03903"/>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055702" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56489" checksum="EEC43AF22C7A00CC" modified="2010-05-18" version="1">MLRLNSLSSSCLATLLATYLGAASVSAQSPPENLWPVQTFQSTDIQTPFFNVTKKGQTEPGYIFFSPRDKARKIGHPAIFDDNGQVVWKGPEDASTYGFKPQLLDGKPVMVSWFGFANETGFGLGSMSIFDSSYEKIHEVILPGGDNEYYKTIYEPMKFPSYMDNHEGQITDQGTIVVTVVNVTEADLRAVGGPEKGWVVDGGFLEMDIKTNDVLFRWSAAEHLDEIPVTFSLKPLEGAGTSSKDPWNYIHVNSVYKSGDSYIVSSRYSCNIFLISKEGKIVWRLNGIDGGDFELGPGTNFCYQHEVRVEEHTVDKITLTTHNNDNADFTPDDQTKPTTGLVLDLDLNAKKVSLNRMVWNSEQPVVSRAQGSYQVLGNNHVLMGQGAIPVIEEYDANGAIVMDARFGNDGVTNCYRAYRSAWVGTPKTKPSVKACGADPNGAVVFYVSWNGATDVDSWKIFAVSDSGEVKEIANFPKNGFETRMELQKAGSKFVVQAVGGPNDGVQSDVVMGENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y8</accession>
    <name>D4D9Y8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021945.1">
        <property type="nucleotide sequence ID" value="XM_003021899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y8"/>
    <dbReference type="GeneID" id="9578828"/>
    <dbReference type="KEGG" id="tve:TRV_03931"/>
    <dbReference type="HOGENOM" id="CLU_1078447_0_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="29355" checksum="E639565086180AEA" modified="2010-05-18" version="1">MSKSVPPFLPELVPPNATADKPVGCWPLIWGRQSTLSYVIDLDLLFNEPLSALYSDHKKDLRNHGDSLHHPKHDYTELALDVEYFIHQHSLQDPILIGHSMGMRHIQSQAAPVSSLSEADALLSQFEPDPAIRLFLLTNLTRKSGKDHLHFRVPLDILSSSLDALGDFPYTDPRKTRFEKPALIVRATRSHYLPDHSKELMQTFFPNLKMVDFDCGHWVITEKPHEFRQKLQELDTNERGGPFSAAVDFLRDTVLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAR8</accession>
    <name>D4DAR8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021705.1">
        <property type="nucleotide sequence ID" value="XM_003021659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAR8"/>
    <dbReference type="GeneID" id="9576788"/>
    <dbReference type="KEGG" id="tve:TRV_04216"/>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="33"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="207"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="385"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="108747" checksum="B4F48C63BA7E09B0" modified="2010-05-18" version="1">MGGLAQRDGPPSGADEFLKLISNPFTSKLNYNAFWVSLGTSVGITAGLALLFSLVRPRNSVVYAPKLKHADKAHAPPPLGKGIFAWITPIIKLKEDELVDRMGMDATIFLRFTRMCRNMFCVMSIVGCLIMIPVNVHYSNRSLGQDKSLFDFMTPELVWGEPLWSNIACAWAFNFIIMYFLWRNYRAIHRLRIRYFQSPEYQKSLHARTVMVTHIPQNYRTDEGLLRLTDEVNPTASIPRASIGRNMRELPGLIKEHDAMVRKLEEVLAKYFKDPDNLPPTRPTCKPSKKDHSGHSTSEPVDAIDYYTDRVRQLEMEIRHVRESIDKRNAMPYGFASWDTIEDAHAVAFAARNEHPHGTTIRLAPRPNDIIWDNLALTKSNLKWKRFMNAIWSTILTVIWIVPNAMIAIFLTNLSNLGKVWPAFQTSLNGNPKTWAAVQGIASPAILSLVYIVLPIIFRRLAISAGKKTKTARERHVIHSLYAFFVFNNLVVFSLFSTVWQLFAVIIDASKNGEDAWKALQARGTFQSFVVALIHVAPFWVNWLLQRNLGAAVDLIQMINMVWIFFARKFFSPTPRKYIEWTAPPPFDYASYYNYFLFYVTTALCFSTLQPIVLPVTALYFGVDSWLKKYLLLYIFVTKTESGGRYWRVIYNRVVFAVILSNFVTGLIVTAQGSWTMVYSLVPLPLLMLGFKWYCRVTFDNKMQYYSRALVTDPEAMASSKSSKKMVERLSSRFGHPALYKPLTNPMVHAKAAGALEKFYQSRQGLGAETGEYSDIAMHRMSSTRPGKSEHTRDRPFEVVAENQLDFSYFKDRPDFRDEFGGGIYGRPDDVFTERSHTPKSFLMGTGDSPSSSRASSPTPSTYSQQARGSMSFPAHTHSRVPQLSDHPAFQPNEPEEPSFYTAPNESERRLLSHAQTTPFRHDAEMSSIDRWQSHTSEAREPSPSGFTPYRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS6</accession>
    <name>D4DAS6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-containing monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021644.1">
        <property type="nucleotide sequence ID" value="XM_003021598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS6"/>
    <dbReference type="GeneID" id="9578605"/>
    <dbReference type="KEGG" id="tve:TRV_04224"/>
    <dbReference type="HOGENOM" id="CLU_024886_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="522" mass="58487" checksum="B1CB4FAFB08FCD65" modified="2010-05-18" version="1">MSLISSVGRSLAHIYSQCFIICYTLIQDILVYVFATNAPPPSSRNKRLRRPRVAIIGSGLTGVSAAAHCVGHGFDVKIFEARPKDKGLGGIWSRVNSTSSLQIHSIMFRFHPSVKWKDAYPNQQQIKDQIVELWKTYHLDDKTVFDTPVKSTRKNDQGRWVINDDEDTHGTFDGIVAAVGSCGDPKMPTLPHQDKFTGQVYHSSELDGLDAKGKRIVVVGGGASAVEALEFAVNAGAANIDVLSRSDKWIIPRNVVVDVLLACNIFGQETILSFIPETLLRKLFYRDLEDIAPSGKGLFTDTPMVNSDLFELIRAGKARWLRGDILSVEEDGISFNHRAQGVPKSGPGHEIFVKADIIIMATGFIRPSLSFLPQEVFEPPYDPPNWYLQIFPPAYPSICTNNSTFVNAIGTVGNYHIGIYTRLLLMFLIDPLSRPREYLMKRWVDMTRIMKRFAPTGAFDFFTYAELLYWFVFVMVFNPFRWKWAAFVFFGLGRVLPMAVVDKEDDARELLGADSRSSVSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAY1</accession>
    <name>D4DAY1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021606.1">
        <property type="nucleotide sequence ID" value="XM_003021560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAY1"/>
    <dbReference type="GeneID" id="9578567"/>
    <dbReference type="KEGG" id="tve:TRV_04279"/>
    <dbReference type="HOGENOM" id="CLU_029471_0_0_1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="229"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="39373" checksum="79392502EE2A98F2" modified="2010-05-18" version="1">MGAIGSLDAHEHPPARLRQQYKAYRALKVPDIDSHPAIIDLRRDDDSDSLPNGISLDRWLTQGSLEAAFSQFMGGCDVRGVPQPAAEPLPVYTHRDIPGLEIIPSILPPGVQVELLSRLLHRDLSDQRHQTNLHLHYNVTYPDASCLPGIRQTGDNPSFFEDSLSRSILPKDSSVHTPLTIQSMLNRKLRWMTLGGQYDWTKKCYPAGQPPPFPLDISHLLQGIFPATQPEAAIVNVYSPGDTLHIHRDVSEECDTGLISISFGCDGLFMVSHADNSDLAVIRLRSGDAVYMDGASRVSWHGVPRILPDTCPSWLQDWPGDASKKGGGRFQQWSGWMAAKRVNLNVRQMKPSGPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB60</accession>
    <name>D4DB60_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021512.1">
        <property type="nucleotide sequence ID" value="XM_003021466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB60"/>
    <dbReference type="GeneID" id="9578460"/>
    <dbReference type="KEGG" id="tve:TRV_04359"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_0_1"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="259" mass="29289" checksum="2D9F0ACE72F4437B" modified="2010-05-18" version="1">MVDIVPLCSYPSYISLLPAVQTCNITNLPENYFLKYYLYHALSWPQLSFVAVVRDRSSKSKDPFAPAANPKVVGYVLAKMEEEPSDGLPHGHITSLSVMRTHRRLGIAERLMRMSQRAMAESHKAHYVSLHVRVSNNAALRLYRDTLGFEVEKIEPKYYADGENAYAMKMDLTSLWLKDDEGYSVGLDGKSFKNTDEDVDEGDEVGDVGKAGDEASKEEKKIRVKEILWSGMKVERRLEGISSPGWIFDDKKGRYGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBL5</accession>
    <name>D4DBL5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate carboxypeptidase Tre2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021360.1">
        <property type="nucleotide sequence ID" value="XM_003021314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBL5"/>
    <dbReference type="GeneID" id="9578240"/>
    <dbReference type="KEGG" id="tve:TRV_04515"/>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="504"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="7">
        <location>
            <begin position="768"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="102822" checksum="85740C8963A57706" modified="2010-05-18" version="1">MGDQKVPYEHLPIPTYEEATSSRPSSSQSRLGHREVSDDAERQGLLHNHDTAGERSQRPFLRGYRPPTVESARSSLDFLSDNGSSARGSTEQLRRELEEMEVEDPPQASSSSSSSSFAKRFTSFKRTLSSINLPLRKYFPSFTLPSFDFRFNICAGIEHQQRCIILLRVFAVCLVASLVYLLFVSNFFSFSNRINQGQIYQPESVRVFLENHINETAIGQNLERATNFPHIAGTEGNYALAKWVEENFKSYGLESVELEQFDVYLNYPKKGGRKVAIVDPPEARWEAQIEEDQVYTDPPREQTMVFHGLSKSGNVTGPLVYANYGSKQEFKKLADMGVSVKGSIILIRHYGTQPDVALKVKAAELAGAAGCIIYSDPAEDGFRKGDPWPKGRFMPKDGVQRGAVNRVAMAAGDVLSPGFSSRTDEKKRLKVDEAKGLPQIPSIPLSWKDAQHLLMALKGHGKKVPKDWVGGVPDINEWWTGNEDSPKVNLMNLQDEVERQPIYNVIGRIVGVEQSKNSIILGNHRDSWCFGAVEPGSGTAVLLEIARVFGELKARGWRPLRTIEFVSWDAGEYGMIGSTEHVEDRTELLRANAFAYLNVDVAVSGDKFSARGSPLFEPILLHILNRVPDPRRRATIRQLWDKAGSKLEGPDAEGDSLPFQTISGTSSISLEFKGDRYPAHSCYSNFDWIHKTGDPGFLYHRAMGQIWGLLALELCSRPVLPFDIHPFAKALTQYVLDLHNYAKKISVPLKPLKSRDKNDSNKPDDGVVDLGPLYDAANSLNAEVAKFHRWEGNWNATIYDQNGFEDDVSALRRMTHNTHMAYFETNLLDLEQGGGVSFLSYCLFKTPSSNLISQVPNRTQYKHMIFSPQLWPENPEDSTYFPAIRDAMDSRDWTQTQVWIDKVSKIITNAAVRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC13</accession>
    <name>D4DC13_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021233.1">
        <property type="nucleotide sequence ID" value="XM_003021187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC13"/>
    <dbReference type="GeneID" id="9578078"/>
    <dbReference type="KEGG" id="tve:TRV_04665"/>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="285"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="717" mass="78283" checksum="073BE93855283634" modified="2010-05-18" version="1">MCDNLTIILGSRAASLSSQLSRFATTPRRHHSTLSFAQLNRPSPVPKPTGLSPLQCQRFLFGGSSQNVLARMERSANNNPGSAAAQNSFYNALLKANMPGIIIERYRSGKFASNSLSEAVYAKALQKVGSGSEQALGQGQQQQQLNPANQNLSADQLQAIGQAVAARSYGGQIGISNKNSGTGAKDTPLYVVVDESLGSSIFRWVRFFLFFGFITYFSLLLVTVFVETTGIMKNVRGSQANEAKPEHQTVRFSDVHGCDEAKDELQELVEFLSNPERFSSLGGKLPKGILLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEIYVGVGAKRVRELFAQARAKAPAIIFIDELDAIGAKRNERDAAYVKQTLNQLLTELDGFSQTSGVIIIAATNFPELLDKALTRPGRFDRKVDVNLPDVRGRVDILNHHMKNIQVSTEVDATVIARGTPGFSGADLENLINQAAIRASRDKKAKVGPEDFDYAKDKILMGAEARNRMLRDEDKLKTAYHEAGHALVAYFSPDAMPLYKITIVPRGVSLGTTHFLPEMDIVSKDYTEYISDIDVSMGGRAAEELIYGPDRVSSGISGDIRSATQTAFTLVTQYGYSKKLGNVDLNTGYDMLSASTKQDIEDEVRRLVDEASARASAILKEHRHELELLTRALLEYETLTKEEMERIIKGEKLDKILMPSKTPIKLPEALTSVHINPVTGSTSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC73</accession>
    <name>D4DC73_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000237">
        <property type="protein sequence ID" value="EFE40559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021177.1">
        <property type="nucleotide sequence ID" value="XM_003021131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC73"/>
    <dbReference type="GeneID" id="9578021"/>
    <dbReference type="KEGG" id="tve:TRV_04725"/>
    <dbReference type="HOGENOM" id="CLU_003527_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055481" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="276"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="897" mass="96717" checksum="01243214DB80C809" modified="2010-05-18" version="1" fragment="single">LPFKRANIYKFTLLAKLAHGAALIPRADADTWTYLGCYTDQVGARTLGQVGYTLGGPGNMTVANCQNGCASQGYSLAGVEYSSECWCDNQLRNGGGPAPDGEAMCSMPCNGNPEQKCGGPGRLNLYQNTAIKPTDTMTTSVTSTETGSPTTTSVPEPTQGLPDGWQYSGCYQDNVNGGRVMFKMLPDSSTLTIESCIAMCVKLGYTVAGAEYSKQCFCDNYLRNAAPQAIESECSMTCSGNTQQKCGGPSRLSVYSKGNLTVLPIPVPQTGGLPGGWKYQGCLQDNVNMKRTFPYQIVDKTNNTATNCLSRCSKFGFGAETGSVTNQQYLVCGDFEDIAAAGAKLVPEAMCSQTCSGNATAICGAGNLITYYRWMDESLQKWNRPTGINAGRYDFLIGGVLVPLITTVGINGKITFQEKSGTGDPNTTGAYEFDPYYEKDFSKAWREMHVKTDIFCAGGLVLPDKVGRQLTVGGWSGISTEGVRLYWPDGSPGKPGVNDWHESPDDLRLQNGRWYPTAMTMSNGSILVVGGEEGSNGAPVPTLEILPRVGPVLFMDWLKRTDPNNLYPYLTPLPGGNILAAYYNEARILDERTFDTVKTLPNIPGAVNNDAGGRTYPLEGTMVLLPQKAPYTEPLGVLICGGSTPYGGDALDNCVSIQPEVPNAEWVIERMPSKRVLTCMAGLPDGTFLILNGARKGVAGFGLAEDPNLGAVLYDPSKPVNQRMSIMANTTIARMYHSEAILMADGRVLVSGSDPQDPRFPQERRVEVFLPPYILSGARRPTFTIANKDWAYGGKYKIKITSGNQSRIKISLMGMVSSTHGNSFGSRTIFPAFSCSFGTCTITAPPDSHTCPPGWFMLFVLDGPTPSIASFLLEWKILTATFAITTNTKCFDINIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCA5</accession>
    <name>D4DCA5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021143.1">
        <property type="nucleotide sequence ID" value="XM_003021097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCA5"/>
    <dbReference type="GeneID" id="9577986"/>
    <dbReference type="KEGG" id="tve:TRV_04758"/>
    <dbReference type="HOGENOM" id="CLU_008964_4_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="45"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="831" mass="93580" checksum="4C69433A2A0BBCDD" modified="2010-05-18" version="1">MITIDITGTVGIEEKNASIDFLSQNMREMVKKIQDLRHLGIENHTLPLPKIVVVGDQSVGKSSLIEGMSEIKVPRSAGCCTRCPLEINLSESDGPWTCRLLLMKKYMYDAAGRTQRATNARPLGPWIEQDPEELYFATLTDKTLLQKHLKWAQLATLNPGRSHTDFIPGEDQETDSTYSQVKFSPNVVRLDISAPGFPNLSFYDLPGVINVAELDEERYLVGLVENLVKEYIKAQNCIILLALPMTDDATNSSAARIIRDIPGARDRTVGVLTKPDRVELKTGNEYDQWREILRGEKFATGHGYFVVQNNPDPRIDHATARADEGYFFSNPPWTTELAEYNDRFGTRRLQTALSKLLLRLIQDSLPRIINQINIQAQYVDQALAKLPNPPSANVSYILCQKLNSSMNNVQMHVDGGSAQYPFLKQWGIIASEFQQYLTASRPGLKLNTPSEFIPESKGDASASSSKAQKRKNTPQTNGTGDLKKMKVGDLANGSTPDVSEFKVHGHFDHFPMTLKEPARSFTLPEVRNINADTYASGVPGLGNPHAVEALNRISVSHWEEPMKTFLLVTYRLMAGVLLNEMRYVFGQYEQTALFEELKVIIMGFLESIRIEHFQQAESVFNIECLKPFTMANDLFRRGQEEAYGYFFHKRYEARVSQYTKLIDAQQQQTTGRSSRTDPSKVTEKELGPDEFAKELEIMSGIHIKLFMRCRDELRGEIEQKLGILNENGMNGSTKCDNSTANEEKPSFRALHGINGRGPRKTVEENASSEGKGETRQSSGMVEGRRKNPGAPFLRLQFLIADSHGYLTQKKLWDRAFNRNRGHVVPVSLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI3</accession>
    <name>D4DCI3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021062.1">
        <property type="nucleotide sequence ID" value="XM_003021016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI3"/>
    <dbReference type="GeneID" id="9576709"/>
    <dbReference type="KEGG" id="tve:TRV_04838"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="516"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="636" mass="71299" checksum="247CED853775FC60" modified="2010-05-18" version="1">MASTSIQGLEALLQSLKVSTPIPQFPQANVLFAPADIYRSYIAEVIQKLVECDKDTAYDAVQWANAATNADLMLITARLKLKGINPKQLAEDIVSKFPSTSLLSQPTANGIFIPLSFCPDTLPKLILPFIFDRRASYGSNPLQGLRDPHDQSSGKKKVIIEFSSPNIAKEFHAGHLRSTIIGAYISNLYESMGWDVVKVNYLGDWGKQFGLLAVGWQRFGSEELFTKEPLKHLLEVYAKINSLFAPEKEASEQARDRGEDTSEIESKGLFAERNAFFQKMEDGDPDAIALWKRFRDVSIERYISTYARLNIKFDVYSGESTVKVSTVEKAEALLKEKGVYTEDNGTWIIDFKKHGAPHLGVAVARTRIGTTTYLLRDIAAALERVEKYQFDKMIYVVSTEQDLYFQRLFKTIELMGYTDVAAKLEHINFGKVMGMSSRLGTVKILSDILDECGSAMHDVMRKNPAKYEQIENPAEVADTLGITAVMVQDMAGKRIHNYPFDIAKMTSFEGDTGPYLQYAHARLCSIVRKVDIDPKEITTANFSLLKEPHAINILRLMAQYPDVTCNAVKTLEPTTILTYLFRLAHQVSSGYDVIKVIGAESHEVTVARLALYEGARQVLENAKVAAKEYFRDPFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCJ6</accession>
    <name>D4DCJ6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair and transcription factor Ada, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020986.1">
        <property type="nucleotide sequence ID" value="XM_003020940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCJ6"/>
    <dbReference type="GeneID" id="9577838"/>
    <dbReference type="KEGG" id="tve:TRV_04851"/>
    <dbReference type="HOGENOM" id="CLU_634901_0_0_1"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="431" mass="46821" checksum="F2A8C942D9AA3B81" modified="2010-05-18" version="1">MTAETDNKSAYATTSARWRAIVNRDAAATGFVYGVRTTKIYCRPRCPARLARRANVEFYDTPLLAEKAGYRPCKRCKPEDVRAPTDPHIRLAQRACETMTLAALAGGDKQRPTLSDLSGEAGLTPSHFHRVFKKVVGVTPGKFARELMERKSLGKVVVPSGINARICWPPPHLAPLVGMSSPVQDSNNNNSASSLEPQVQTPPLGDCDIDQIIGQGYSDPQAVGPINWNEFDLMLAAASDPRQQQQQQQQQHHHHHHQQQHINFSRPPTSTPASTSAAVTTSSSPAVGGGSGICMPQTTASHSFDPNSLNNIHSMLTLDPNSTSNINFAQYMAEPIDFSPMNPPTTTNSSTNTTTGHSPPDTFAHPTPSPTSVPSLYSQQSISPTDSPLMFDSYIGLTGSWPPLLPEDTDWLDNQVLLPPDYTSLDFCARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL2</accession>
    <name>D4DCL2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_04867</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021002.1">
        <property type="nucleotide sequence ID" value="XM_003020956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577854"/>
    <dbReference type="KEGG" id="tve:TRV_04867"/>
    <dbReference type="HOGENOM" id="CLU_000315_26_0_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="432"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="668"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="278"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1426"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1439"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1451"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1494"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE40384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1522" mass="172036" checksum="4A0AAC1D334C4EDD" modified="2010-05-18" version="1">MGDTVMHSPKREPDIPLDSRSANPVYSSSSSQPPMAREARATTPKEQKPARATDPMSFASILSGPAEERPRKASVPPVKASEPPPQPVATPAPKPAPKPASKPEPRVLESDKRRRHHNYDATYSDIAPKPVANGTASAKSAPPLASAKQSSSSHSRGESNNVTTALERLDNLDKSDLEAPGFEDEWQRYIIKGRKRAREAEALDNQKRKRRRANFLGKLARVFEKQAIAGTERFARLHEAEVIEEVQQKEIMDEKERKKDMQRKRRRENTVRAEMEKIQAAQKKVSKMEDDAEKEKLQREIARSRKKIKHTKHVLETGSAPQEISEVAPLSPNLEGGTTGSFHTRDKPSPNKKRPSKGGSAARPKKTKEQKQAEKDAAEAAYAAMEGEEPSATASKDKKPAAKKDAKASKEPTPAPVATFDTKGYAQLYEQIWRDMARKDIPKVARMKTTSLNIRQENCRKTAQLANRTNRSTKDTQARAKRTMREMMSFWKRNEREERDLRRMAEKQELELARKADADREANRQKRKLNFLISQTELYSHFIAGRSKPTKLNSLPADGAKEPDTSLNVPDDLGDLSAKVTNFEDLDFDAEDDTALREAAMANAQNAVKQAQDRAKAFNEQENKMAAFDEGEMNFQNPTSLGDVQVAQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAEVHNIWGPFLVIAPASTLHNWQQEITKFVPDIKVLPYWGSAKDRKVLRKFWDRKHITYTKQSEFHVLVTSYQLVVLDAQYFQKVKWQYMVLDEAQAIKSSQSSRWKNLLGFHCRNRLLLTGTPIQNNMQELWALLHFIMPTLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRIKKHVQKELGDKVEKDVFCDLTYRQRAYYASLRNRVSIIDLIEKAATGEEADSTTLMNLVMQFRKVCNHPDLFERADTSSPYSMCHFAESASFVRAQPSVPYSTRSLIDYDLPSMLCSSAGRLDIPGPNNSKAGFDDKYLSHLMNVWSPENMRHSLGGDDAFSWLRFTDLSMEEARSISEKGVFERALERHGVENRLARLSIVYDDDETSTNSLLPHSLFKIVDRNSRSELTKHGSSGYLRELFNVTQTVIDNQGILGFEPCGKYDANAPPIMISSASSVPDLEAQNTFFNVRARQALIGTTTRGLDEDILNHKVNPLPYSYPPMLPKPGSTKRGYTNITVPSMRRFVTDSGKLAKLDELLRELKNGGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVLDFQQRPEIFIFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLITRGTIEERIRKRALQKEEVQRVVISGGAGGGVDFNTRSRENRTKDIAMWLADDDEAKILEQKEKEALEKGEEAAAAPKKGRKAAPKKKRDVTLDDMYHEGEGHFDDLSARPSGAATPLSADVEAPAAGPSGKGGRRRAPAKGTSKRAKTAKERLQFIDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCS3</accession>
    <name>D4DCS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000250">
        <property type="protein sequence ID" value="EFE40349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020967.1">
        <property type="nucleotide sequence ID" value="XM_003020921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCS3"/>
    <dbReference type="GeneID" id="9577819"/>
    <dbReference type="KEGG" id="tve:TRV_04928"/>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="399" mass="42833" checksum="315F2D41257D1FFB" modified="2010-05-18" version="1">MSFRRRNIGLSSGGPRDPSANAQQPAQQVKPAESTPGLRPSPIDGRQTTSTGTPTLDSLLAGHAGLALGSSLLIEESGTTDFAGALLRYYAAEGVVQEHRVHVVGFDRQWAATLPGLIGAAEASESSPSRNKEDKMKIAWRYERLGGFGLGIAGSRVPAATTETAGDAQQASQGNTPNVFCHTFDLTKRLTHPSIQTMNFIPLTKPNASTNSPYSSITKQLAEAIESSSPNTIHRLIVPSLLSPALYTTHASQPEHVLQFLHGIRALLSTYSSRLTAMITLPISLYPRSSGLVRWMELLSDGVIELAPFPHTLDPSSLASSGAATSQEEPPQGMLKVHRLPVLHERGGGMDKNVGEDWAFTLSRRKFAIKPFSLPPIDGDNDGQQQDASSAPKKEDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD15</accession>
    <name>D4DD15_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine-serine rich protein MS8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020883.1">
        <property type="nucleotide sequence ID" value="XM_003020837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD15"/>
    <dbReference type="GeneID" id="9577716"/>
    <dbReference type="KEGG" id="tve:TRV_05021"/>
    <dbReference type="HOGENOM" id="CLU_083991_2_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="22669" checksum="E52C8148F8B52DE8" modified="2010-05-18" version="1">MSGYYGGPPQGGGYDNYGQQQGQYYQGQGQYQQPPQQQSYGGQHQGPPQQGGYYDQGFPQQQQQYGYNAHQQYDNGGQHQYGGGYPPAGQQQHQGESNAYYGGGPPQHGGMQGAPAYPQGPGGPAGPGGPEGERGLGSTLVGAAGGGFMGHKLGGGALGTIGGAVIGAVGANVAGHAIKDHKKKHKGDKKHKKDKKHKKEKKRGHGSSSSSSSSDSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD88</accession>
    <name>D4DD88_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020788.1">
        <property type="nucleotide sequence ID" value="XM_003020742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD88"/>
    <dbReference type="GeneID" id="9577539"/>
    <dbReference type="KEGG" id="tve:TRV_05095"/>
    <dbReference type="HOGENOM" id="CLU_033361_1_0_1"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000007">
        <property type="entry name" value="Peroxisome biogenesis protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63426" checksum="F95E974688273D61" modified="2010-05-18" version="1">MAAAGVTENTKPRGTLKREKLEVEDDETDDETGSLAYLPRKRAARHRGKVKSFPKDDPKKPVHLTATMGYKAGMTTIVRDLERPGAKMHRKEIVEAVTIVETPPMIAVGIVGYIETPRGLRSLTTVWADHLSDEVKRRFYKNWYKSKKKAFTRYAKTHADAATTTRELERIKNYCTVVRLLAHTQIRKTPLKQKKAHLMEIQVNGGSIADKVEFAHGLFEKPIDVDSVFEKDEVVDVIAVTKGHGFSGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQDGYHHRTSANHKIYRIGKADDEGNASTEFDVSKKRITPMGGFVRYGEVKNDYVMLKGSIPGVRKRVVTLRKTLWPQVSRKATEKVDLKWIDTSSKFGHGAYQTPAEKRAFLGTLKKDLASSSAGRALSSRLSLPSLSLRLDRLNRLDRLALQHQYQQYQLCQLRQLHKMSSDSAYAAFLDKANQGLDSTAATATDKADKKDDQDSGFIASKTLDVDEQRVPPSLRVDAFYSSETDEPFEPVVLALDHLPSKGILSLSLSLSLSLLYFYDFYLAIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD91</accession>
    <name>D4DD91_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020791.1">
        <property type="nucleotide sequence ID" value="XM_003020745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD91"/>
    <dbReference type="GeneID" id="9577542"/>
    <dbReference type="KEGG" id="tve:TRV_05099"/>
    <dbReference type="HOGENOM" id="CLU_633084_0_0_1"/>
    <dbReference type="OrthoDB" id="5347452at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055444" evidence="3">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="399" mass="41583" checksum="FAE7CEA54CD7A759" modified="2010-05-18" version="1">MVGYSLALVAALLSVAIVDAADLEHMVPVATPAGLIALNGRSPKPTPPPGLPDGIPLELVKRQASSSASLLIPFPPPAYYCGLVDGDPENPLTCVNARATCIYTGNAAGCCLSKNINDCTTIPTTCYPSSVSCDSACSRDLLALRCSISTLPYCGTYVFNQNTKLYGCYSYASVSNNISPLSQYYSSVLGPDYASKYSATHIPSTTTESYSNQPTNTGTDGSPQPSNSTSPTPSPTPPPPPSGAGLGGGAIAGIVVGCVAGVSAILIAIWWFVLRKKPDNAPAPAPATAYTQNNNMPPPSMNQQGYYQTPSAAGGYYAPVEQKPPVDDQLPTYPNEQKISPFSQPPQQPPQTQHAEMPGSNVGSPQQMSPIPSELASTPMSATHNGPVPEQIYEMGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDW2</accession>
    <name>D4DDW2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000276">
        <property type="protein sequence ID" value="EFE39956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020574.1">
        <property type="nucleotide sequence ID" value="XM_003020528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDW2"/>
    <dbReference type="GeneID" id="9577279"/>
    <dbReference type="KEGG" id="tve:TRV_05326"/>
    <dbReference type="HOGENOM" id="CLU_869298_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000005">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="320" mass="35500" checksum="59093D48383AD512" modified="2010-05-18" version="1">MEDGLLPLWQINPPRNLGFFLKSRLTCFRFEGIVAKGMAAWVRALSKEYPTLAFHASINNSFGKGSLIQLLRQFSILHSDRKQISVGFIGYPNTGKSSIINTLRKKKVCTVAPIPGETKVWQYITLMKRIYLIDCPGVVPPSNNATEEDILLRGVVRVENVENPEQYIPAILKKTQQRHIERTYEIKGFTDATEFLSILARKGGRLLKGGEPDVNSVAKMVINDFLRGKLPWYTPPPKADDAGDEKINGREGRLGEMGIKRKADEAQGDDGDEVRSGPDASEDDALENGSDGNEDESEFEGFEDSDDEDGGAPIDTDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE62</accession>
    <name>D4DE62_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020462.1">
        <property type="nucleotide sequence ID" value="XM_003020416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE62"/>
    <dbReference type="GeneID" id="9584201"/>
    <dbReference type="KEGG" id="tve:TRV_05428"/>
    <dbReference type="HOGENOM" id="CLU_052049_0_0_1"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="32544" checksum="CD9C36D964967C0F" modified="2010-05-18" version="1">MRIPRDLHGQDILPLAAPNSLRGRPSYSPRFAPAHPDEDASLANIAEAEDSSTTEGTMDASMPLLRRVGHRSVATARNSPSAIPAPSFSQAESVMSADDEVPDVSDTWARLLNTIPLDNNLPSADSSFTSATASASASGSGGSRSSTAAPTSLTPSSSFGSSVSARMHIMFDPFPSFPANCDYISSSDNSDTETEDHDLERHRGYSRQSQPRSQSQSQSQTPTQTQNPAQPQSESNTPTDSSAPTASSFTLENEAAGLQLLHDTLNLLSRRDDIPDEWWATAGLTRIINRELNRELSRDQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEA7</accession>
    <name>D4DEA7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000291">
        <property type="protein sequence ID" value="EFE39817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020435.1">
        <property type="nucleotide sequence ID" value="XM_003020389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEA7"/>
    <dbReference type="GeneID" id="9584173"/>
    <dbReference type="KEGG" id="tve:TRV_05474"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="640" mass="70032" checksum="F81C4DAACC545BF9" modified="2010-05-18" version="1" fragment="single">MTTTISSLPGEEPVPIPLTSTSHPNDPVPEEPTSIPHLTLLRRSATGTSDSQSAATSVAGASEVSIDSDVPLTPITEPSSDTALEDTYAEGKESDGITQRRRRASTVLISQNSEDVQRILGDIRGGTNLLGKICCGGGCCKLEPLKNALPSITSNPVVRPQNAAFESLRLYVGELSLDSKLTKIAPLPENTVSFSSPSIDSVGKKLGPADHPPQFLQPHAPYEVYRAPLYHARELTKPGAEKRTYHFDIDVTDYPVEGGNVDFVVGGAIGVCPSNSEAVVEAIFNRLGVPKFIRDKKITLHTTKGRWPTIWGDEKPRDLLTTRRELLSWCSDLQSYPPTKPLLRLLAEYASDENEKKILMYLCSAQGQAAFCDLRTGPYITVLQLLDAFPSSHPPLDHLLSTLNTLMPRFYSLSQDPMIQRTIDGKEPRRVIEIAVTVHECLDWNGGYRTGVGSGFLERLARKIQSAENDGIDPASLNLHVPMFRGLMSNPLARRFVSDGPMLLIGAGVGVAPFRGFVQSRLRSANCANKVWVLQGVRDSLLDELYSGEWGVHEDEVKKVVESRRGEGRYVQEEVRHQADLVWFVINSLDGRVFVCGSSKGMGEGVEAALIDVAIAKGNLNPEQARIFWDEKKAAGQYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEE9</accession>
    <name>D4DEE9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05516</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020398.1">
        <property type="nucleotide sequence ID" value="XM_003020352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEE9"/>
    <dbReference type="GeneID" id="9584124"/>
    <dbReference type="KEGG" id="tve:TRV_05516"/>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="157"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="304"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="452"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="622"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="800"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="959"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121189" checksum="4D3183E20D8B1BC0" modified="2010-05-18" version="1">MSGPTLKRRKLSSGEEEDSANTSKKPKSPAVQRNGRPSNSAAEYALARGQFKSSMFKLQMDELLGQLRPDYDKLLSRVEKSLRKLKTVIEEIPNGNPKTLAEAKKEFESSKVAIPFPEPPPAKDVRYTFEYSKPVDINVVGSFALKTMAKGQGPTYIDLAVTLPSTLFHKKDYTSYRYFYKRAYYLARIAAAIKTAEDVDFSISYTYQDGNTLRPVLLLQPADGAEDDFSRSNCVIRIITAVEKDTFALSHTFPSHNSLRLDSEAEHKSIGANSTHIYNASLRSEAVVSAYLKLHHSAGVKCAAFKDSCILGRAWLRQRGFGTSFASGGFGHFEWATVLALLLEGGGPNGKPVLAPSYSSYQIFKATLQFLSGKDLTKPLLMHAPEGLGTVADTGFPGLFDGKRGLNILYKMTPWSYKLLQREATLTLKMLNDSTRDHFDSIFITKVCDAFYRFDQVISITLPGRRPPTIQAAERLQSLHRVLTKALGDRATAIDLTSGEVPSWAVKSTSPPKESKKWTIIAGLNLDASNQGRSIDHGPSVEDKEESAAFRDFWGDKAELRRFKDGSIKESLVWSDQASSGTPVQQILTYILHHHFKVTPENIVYMAADIGQAIPGISNALSTTPASEPVLEAFQKLERHFQSDESLPIAFSQLLLATPFIRCSPDSPGAPMDAVLLFQSSSRWPDDLGSIQMTKVALLLKVEESIRKADGVIEARVGTENNESNLLNTSFLEIHYSPFIIFRLRIHHEPEQAIIQAQLKSKDLPARKKEELAVALAAYKATFLQAPRHAQALQSLSNRYPLLPIAIRMLKSWIGAHLLAPFVREELLELLTCQIFLASYPWDAPSNAFTAFLRTLHMLSKWDWQHEPLIVDFSGELESQDFTDIRTRFEAWRKIDPVMKNVALFAASNIDPDGVTWTQHSRPSRIIASRMVMLAKAASKLVREKGVDLEVGELFRSPLDDYDFLLHLSPSFFSDRSKKAAFKNLHDSALTSEYAKHEMVRDLVAELSSLYGEHILFFRGHASEKVIAGLWNPQTTKTQPFGLKIGFSSYPKKTQDREEVALNKRAILNEIASIAGDIISKVQVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEL4</accession>
    <name>D4DEL4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000300">
        <property type="protein sequence ID" value="EFE39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020325.1">
        <property type="nucleotide sequence ID" value="XM_003020279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEL4"/>
    <dbReference type="GeneID" id="9584065"/>
    <dbReference type="KEGG" id="tve:TRV_05581"/>
    <dbReference type="HOGENOM" id="CLU_005544_0_0_1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="792"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128688" checksum="5D89261CFF5BFB1E" modified="2010-05-18" version="1">MGDTRQKIFQKLRPPCVELSSITLKFKGNLASSSEVLKALDTLYQTLQDVIPYNGLDEKLAEYSFFPLSQIFNESQRISAQCVELALKCLQILIERGWRSRLSAELGKQLLILMTLLTGGAPAQASGPSRPRSEELVVAAFDCVSSMCHVLHGPAAAASIFNEIGSSTIIDQTVYVLLEAIVDGASSDIQRSAAVALKSLQCRITNRVVLASLLPRTVSSLTKVLRGTAQQRRSYKLLCACLEGLTINIRSVLNDSVVTSTTDETQTNCGTGPVVLDKSWLNATASQIKLALSNVIRLRNHEREEVRQSLLGLCLMVIEDCSNSLADSLAMMIETVVVLAHNAAEKDDNEAYRSLKNLLTSSETVTGILKSSLYSWIVALPRAMQSADEAAKSRVIRQISTAFEALSDTQIKSDILDDTMTTSLHDSISAILMSSPTPLQPLGPPIDARPEALSLTGQSHSNTFQPVIFERQSQKETLMELQTMISRLSNADLSFNMVKSMLKKLYQSSGDSFVSSLWLTLSFLKSASPDTLMIDEVLNVESDLSSTSRPQLIEEIYSLALPILTDMQNVDSDDWRTPALALEAVALQAEQLQESFRPELIDTLYPILQLMGSSNPALQNHAVTCLNIVTASCNYPDASTLVIENADYLINSVALKLNTFDISPQAPRVLLMMIKLSGSRLIPHLDDIIGSIFAVLDAFHGYPKLVELLFGVLGAVVDEGARQPALLAISHGDEIAVPQHRRSPAQPRSVSSIADWIKGRREKCSRELQIEGNNLEPLEPHPKKPWSSIPEKSAGEEDEMDINSQADQSEQALEPEEKPLSKPHTLLLNIIKSIPPHLSSPSPYLRRSLLSILTRGLPILSQNEKTFLPLINDLWPSVSARVTLAAQTGRESQALSTTLKENKAQVSDSGIQEETFVTVASCTAIGTMCKGAGDFMSSRIEHEFPRWKCLYGSFWHQVKDDAEKSAERHRQQLAKKQIQEVKSSGSTASAGLVRVLDDSGQPLPQVSFTITKSFTRHHSLWKALTTLYITILSHVSLPADIGDEICYTLADWITFFHPELYSSETWKDDGNSDDAMNDEDADSETRWSRGTLKEAKRALRAMKVWNPDLTWLACVQTGVRHHKSRNARFYSQQELQPIAEKMNNELGQLLGDHEREAGLRFATPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF23</accession>
    <name>D4DF23_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000326">
        <property type="protein sequence ID" value="EFE39549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020167.1">
        <property type="nucleotide sequence ID" value="XM_003020121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF23"/>
    <dbReference type="GeneID" id="9583938"/>
    <dbReference type="KEGG" id="tve:TRV_05765"/>
    <dbReference type="HOGENOM" id="CLU_1983187_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="14297" checksum="7B77C8FB73F4A5B9" modified="2010-05-18" version="1">MNNISKTNQGYSFDSRQRIEGRGRKKKSNSLTWLSGLSIRKSRHVKRSKKEKTRGWRGRGGQMTSAAMMMMMMGDNELDRSVSFAPRSALIFSSGSLFLSDDKAEKRRFFNAGKSKERGKSTHRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA4</accession>
    <name>D4DFA4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TRV_05850</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020077.1">
        <property type="nucleotide sequence ID" value="XM_003020031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583841"/>
    <dbReference type="KEGG" id="tve:TRV_05850"/>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1234"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1299"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1079"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1364"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1374"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="611"/>
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        <ligand>
            <name>ATP</name>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <location>
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            <name>ATP</name>
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        <location>
            <position position="807"/>
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        <ligand>
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        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>ATP</name>
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    </feature>
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        <location>
            <position position="922"/>
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        <ligand>
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        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="924"/>
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            <name>ATP</name>
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            <position position="1033"/>
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        <location>
            <position position="1053"/>
        </location>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="1056"/>
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            <name>ATP</name>
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        <location>
            <position position="1057"/>
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            <name>ATP</name>
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            <position position="1057"/>
        </location>
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            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00049128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EFE39453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1488" mass="167317" checksum="CBD15027E170A5AF" modified="2010-05-18" version="1">MAVVQFGSEDESNVSKPSKRMRWATQRRPGRQGSRKRTSIMDKLHQRAGSKDEKRRSNTSSLPNGSEPSDASDEADRRRIYVNVPPPPHQRDENGKSTITFGRNKVRTAKYTPLSFVPKNLYYQFHNMANVYFLFIIILSIFSFFGATNPGLGAVPLISILTVTALKDGVEDWRRTVLDNDLNNSPIHRLVGWNNVNSTEDNVSLWRRIKKATTRGIRRAWKWFKRVRKGEKPEPKPVVEDTPRMSIATQRPEFRNSTYSYRPSYQADRPGNDSEDIQMTPLPSPGVNGNGKAEPRAPPPFNETPMTHPSKFYGSILNKSWQPSGSARFKRDYWKNVEVGDFIRIYNGEQIPADVVVLSTSDPDGGCYVETKNLDGETNLKVRQALHCGRAVKHARDCEAAQFVIESEQPHPNLYQYSGAIKWSQANPDYPDSPEKEMAEAITINNVLLRGCNLRNTEWVLAVVIFTGLQTKIMLNTGISPRKTARLAKDLNWNVVYNFIILFAMCLTSGIVQGATWGQGDNSLDWFEYGSYGGKPSVDGIITFWASLILFQNLVPISLFVSLEIVRTLQAVFIHSDTFMYYEKLEYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNIMEFKKCTINGVSYGEAYTEAQAGMQRRQGINVEEVSRKAKEEIAQSRASMLKQLRAIHDNPYLHDDELTFVSSNFVSDLTGSSGEEQRDAVTNFMIALALCHTVITERTPGDPPRIDFKAQSPDEAALVSTARDCGFTVLGRSGDDIRLNVMGEERRYTVLNTLEFNSTRKRMSAIIRMPDGRIILFCKGADSIIYSRLSRGKQAELRKNTAAQLEVFAREGLRTLCVGQRILSEEEYQEWSKTYEDAAQAITDRDEKLEEAASSIERELTLLGGTAIEDRLQDGVPDTISLLGAAGIKLWVLTGDKVETAINIGFSCNLLTSDMELIVFNIDPDDIDAATTEIDNNLANFNLTGSDAELLAAQKNHEPPAATHALVIDGETLKLMLSDKLKQKFLLLCKQCKSVICCRVSPAQKAQVVKMVKEGLKVMALSVGDGANDVSMIQEADVGVGIAGEEGRQAVMSSDYAIGQFRFLQRLILVHGRWSYRRLAETLANFFYKNLVWTCALFWYSIYNNFDSSYLFEGTYIILVNLAFTSLPVILMGILDQDVDDKVSLAVPQLYKTGIEQKEWTRTKFWLYMLDGLYQSVICFFMTYLLFRPGQNVSENGLDLSDRTRMGIYVASCAIVCSNTYVLLNTYRWDWLTVLINAVSSLLLWFWTGVYSATTSAGTFYKAASEVYGSLSFWALTFVTVVMCLGPRFTIKSVQKIYFPRDVDIVREQVTLGKYKYLEKYEAYVPPSHAFAAQSSGIMQNSKPAAKRDPNQPEEERPIYPPSVAPTATTHNPRSQNGSDTTAYTASLDLRPPAHQSLEQERNPPRDRVRPSIDRCRSSVDRVRSSFEASSDFTSAAMLARIESSHVRGDPNNHPAIQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA8</accession>
    <name>D4DFA8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020081.1">
        <property type="nucleotide sequence ID" value="XM_003020035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA8"/>
    <dbReference type="GeneID" id="9583845"/>
    <dbReference type="KEGG" id="tve:TRV_05854"/>
    <dbReference type="HOGENOM" id="CLU_302261_0_0_1"/>
    <dbReference type="OrthoDB" id="4188047at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="977" mass="106718" checksum="9F58CF971C8F5484" modified="2010-05-18" version="1">MLRPSTPSRSSEESFCFSAWETPRLSVAESIGRDNYPRPASSRTQTGKKATKRNKNAAHYSPRSAGSARRPQRSEHVTELIKFFKTCELPISDPYNFDLDSLELNGQLRQLKHRQDDLGLQEDSAPQRKKSPVKLFAPDLWSRTPARKNKQKNDRLNPAISMESMQYSPGTRSPRGSHDSNIDRPIATPKTEVDGECAYPGISVLPSSKESPANDIGVSEPFPSLATMGQLYDLSSATLTGDMYTNEKMEWTDTSVGREILSGIDTDSGMPIQPMPVHLNSPSSHNGDNVPQPPPKPAVPHNCAKGSTYWPQDKPLPDTPEVHCQQQRQQIQIYKRDSIRVTRSTTTSSGFGKRHSISTTCESTFIDVQCLPERTSSRKERRAGRTDFSSLCCRLSCPMSEEHGFNYAESLESTENPVSTLDPADANENLDTATQSKSKSRTLIPAPIDSSRKYSVSSEPSLTPSSNIFSISALSGSASSSTLTSPLTWHNPSQKGDDNDASKSIPSTPALTVSHDTLDNQSNVESFPKLPTTNVPEIKGSADTASKILPDHFPAVPVRKSSRLDNIHALRMKDVAAARAALKASKKDSATLENTENVRGRQASSPAILNYSSTTKGSSRSSEESLPSATSSTRPTVKSAMSKVTADSNTKSSTNGSPMRTIMPDGSVFTDRATQERSFRHKHNAFSLLAGGSLPTSPRNSQSFIPTPVPHRPSLMSPKSVAGLRALETVSRPVSPSLPSSDDEGMGTRAHSGRSRRSTRSTPRRNRKSSTLTIDNAKSQKYIHDEPLPLTPPSANAIRPDDPDSLLSPYTPTHFKYLPTSDSSIATQSHQQKFLQDRVFYLERQNKMLQSALLSALEVGAKCDAQRDQKCSPRSSNAINFRDDIIDMLNLYRSSYDGGCGVATSSASATRRETRRSAIPPNIGEAEISCSSTTTSRLSVQGRILARPSTSPSTAKERAHQRLIEPHNRIGEAIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFG3</accession>
    <name>D4DFG3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_05913</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000337">
        <property type="protein sequence ID" value="EFE39425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020049.1">
        <property type="nucleotide sequence ID" value="XM_003020003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFG3"/>
    <dbReference type="GeneID" id="9583799"/>
    <dbReference type="KEGG" id="tve:TRV_05913"/>
    <dbReference type="HOGENOM" id="CLU_005138_4_2_1"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="629"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE39425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="908" mass="99674" checksum="D1C3A9FA884BDF1D" modified="2010-05-18" version="1">MAQKSGGSKQSTLGKFFGSNSNPAPKKQSTLAFSSKSSSSKNDETKEKDDEVAEGAPQTPQKQVGRAESKRTPPPIDDGDVDGEILSGGEKSESVSPVTRRQKRKEAVAIKGDEESDEQPVTKRRRRSPKSNTKAKSPVNGGRSKAAATGEQSPTKIKSDAEPEQSSAEENSASEIEEDDIDDKPAKVQQKKKAAAKQRKQVQSTLTSKPKDLYPDWKAGDPVPYAALCTTFSHIEMTTKRLIILSHCALFLRQVLRLTPDDLLSTVQLMINKLAADYAGIELGIGESLIMKAIGESTGRSLAVIKADQNEIGDLGLVAAKSRSNQPTMFKPKALTVRGVHEGLLAIAKTHGTGSQEKKIAGIKKLLSAADADKAGKGSKTIDITKNRGGASEAKFIVRFLEGKLRLGLAERTVLVALAHAMVAHEAEMDGGKPPSTDQLAKGEDILKTVYRYAPLLNIFGGISELILCDSELPSYEVIIPAMLKHGIFNLPDNCKLQPGVPLKPMLAKPTKSISEVLDRFEGKHFTCEYKYDGERAQIHYISRDTIKEYPAASTTLQKDGEGLCAIFSRNSEDLSKKYPDILEKLEAWVKPGTQSFVVDCETVAWDTVNKKVLPFQQLMTRKRKDVKSEDIKVKVCVFAFDLLFLNGEPTVKKTLRERRALLHEAFVPVEGEFAFAQHGNTSDLEEIQTMLDESVKASCEGLMVKMLDTEDSGYEPSKRSRNWLKVKKDYLAGIGDSLDLVVLGAYFGRGKRTSVYGAFLLAAYNPKTQNYETICNIGTGFSEALLEELHETLSPLVIDKPKPFYSHSTVPKDQPDVWFEPKFVWEVKAADLTLSPRYSAASDEVMGNTGGSAAKGISLRFPRYIKARDDKKPDQATTTKAVAEMYRKQESVAMDKTKGAVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFG7</accession>
    <name>D4DFG7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000338">
        <property type="protein sequence ID" value="EFE39397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020021.1">
        <property type="nucleotide sequence ID" value="XM_003019975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFG7"/>
    <dbReference type="GeneID" id="9580190"/>
    <dbReference type="KEGG" id="tve:TRV_05917"/>
    <dbReference type="HOGENOM" id="CLU_011751_4_1_1"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="758" mass="82294" checksum="AC05C435B9261D0A" modified="2010-05-18" version="1">MEEFLRNWRQDALNKGQYDSAVYIGDKVLALTTLLSTKDLITRNSSCRYLAAHCYIKQNKFDLALSILGEHNPTHLIQSASRRKKPHLNGGSHVTLRNGRSIPSRTDKSDADAYQDANHIKYEAAMCYLRGCCFANQNAFDRARDCYKDAVRIDVQCFEAFDRLMRNSLMSPAEELEFLESLDFDSITPSSDVSLSQEASEFTKLLYTTRLSKYSSCSALSHAIETLSTHYNLADNSDLLLSRAETLYTQCRFPEALSLTSSILSASDSMSALVSQGSQSQNLGHSPSVYPLHLACLYETGATNALFLLAHTLSDNVPEEPYTYLAIGVYYLSVSKIAEARRFFSKSSLLDPHSAPAWIGFAHTFAAEGEHDQAIAAYSTAARLFQGSHLPQLFLGMQHLALNNMALAHEYLSAAYSMSSGSPSTSNTLSLSVNSAGEPPIPGPSGGDPLVLNELGVVLYHEANLEDAVHLFRQALALSVSLECDPSAWLATRANLGHALRRLGKLEEALSEFDECLRIGAGGSTTIYTGYTGRAGAGAVRSAGASAVGGYEDRGLIGSFHTARGIILLEMDRTTDAVTALHEAVRVLGTTGGDAAAGAGVAGTLLSKALEVWAVEEETRVVSFQDTSKARKGKYSSANSNNEKSRHRSTAKGTKKSTTVDEWTDDVPDRPSSSGPDAQNIGMELDGDANDLLEHALALLTKRGLVLTYQNQVGSGRQGQLEGEVLNEALVDDILCQPLPDHRLMPLEHYQKSIFMNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFP5</accession>
    <name>D4DFP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05996</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019950.1">
        <property type="nucleotide sequence ID" value="XM_003019904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFP5"/>
    <dbReference type="GeneID" id="9584702"/>
    <dbReference type="KEGG" id="tve:TRV_05996"/>
    <dbReference type="HOGENOM" id="CLU_022398_0_1_1"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005671301" description="ATP synthase subunit beta" evidence="14">
        <location>
            <begin position="18"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="292"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="623" mass="67256" checksum="CCFA812A9B1B31BA" modified="2010-05-18" version="1">MPLTIHLLALFDIAVLATNYALARGGTGNRRTVSENSDHTRAAFSLFFPFASNLTSSTLSIHPPLFTHLTMFKSGISRTLGRSAFARPSSSVLSSVRPTFKNNALQALTARYASTDAANIGKIHQVIGAVVDVKFDTETLPSILNGLVTDNGGQKLVLEVAQHLGERVVRTIAMDGTCRYFSQRLGIKPDLGAELELRRSMLTRLCTTGTEGLVRGAKVTDTGLPIQIPVGPGTLGRIMNVTGDPIDERGPIKGVKMAPIHAEAPEFVEQSTSAEVLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETRVIQLDGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRMLDPRIVGEDHYNTATRVQQMLQEYKSLQDIIAILGMDELSEADKLTVERARKMQRFLSQPFTVAQVFTGIEGALVDLKDTIRSFKAIINGDCDDLPEAAFYMVGDIESARAKGEKILAELEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFP7</accession>
    <name>D4DFP7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019952.1">
        <property type="nucleotide sequence ID" value="XM_003019906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFP7"/>
    <dbReference type="GeneID" id="9584704"/>
    <dbReference type="KEGG" id="tve:TRV_05998"/>
    <dbReference type="HOGENOM" id="CLU_084805_0_0_1"/>
    <dbReference type="OrthoDB" id="4169126at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="33507" checksum="BD48778FD90F5A6C" modified="2010-05-18" version="1">MSRVIGRPKRTSAEVAQILQTAVKNGLDRKKADRILSEAKMSDYLMNIYDHLDALKNPYLTPETNLPGIKINMGVKPRFFEQTSERELKEKYNLPTFQLDPHTKESPIPPNNSDSSYGLWLDLQEVFSKVGLLAEKSLARQRGLEILENRHGDNPMMIEFTGSPTRTHDYQWCTKMIYKYKDFPHLMVKSLHKITRDGTENCILRSELMILVRLIVLKARKDENEPHEIFPYVIIEAYFDGKYVHVNYGKPIAMSDKLPPKEQDQRMKYVIGWATAQPCGKTASYKDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV9</accession>
    <name>D4DFV9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019864.1">
        <property type="nucleotide sequence ID" value="XM_003019818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV9"/>
    <dbReference type="GeneID" id="9584615"/>
    <dbReference type="KEGG" id="tve:TRV_06062"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OrthoDB" id="4170670at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="326" mass="35325" checksum="066B9541CE9683BA" modified="2010-05-18" version="1">MDESELPADVLIIGGGPAGSNAAWELGKAHHRVTLFVGDKPVSSPGSEAGESSLPAVLKNRELFHLFQQETSKTLPVTVERKRITEVRRLPNGLFEVEDAGGNVWPGRLLILADGAEEVMPDIAGYQTCWQQQRILMHPSEGKHGRVPVAVLAVGDLAELTMALHAVWQIRQYASAVRVYTHGDPELAQELLSRVSPDAAITVESAYIQEIQPDADSSHGVTVQLDGGKSEKAFLYHRRAAQLKGNDPFARQLRLELTESGAIRISARVPYMTSMDGVYAGGDCASLGQRTLLKALAMGEGVAAAVAARLERGRWKNLAYEEESCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFX2</accession>
    <name>D4DFX2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019877.1">
        <property type="nucleotide sequence ID" value="XM_003019831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFX2"/>
    <dbReference type="GeneID" id="9584628"/>
    <dbReference type="KEGG" id="tve:TRV_06075"/>
    <dbReference type="HOGENOM" id="CLU_016305_0_0_1"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="241"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="859" mass="93339" checksum="61B35E17584FEB51" modified="2010-05-18" version="1">MVSVHDLERASTLAREAVELVDAGHKEVRQLFDICHQPDKPVAASRNLREAIAIAPDSEDVKSVFRKIREDEENSHPLLNLCRRFVTQRDESAAGEATKYLRSEGLQPPPEVALECVKLLLAEPASSLPAAQDELITGLVRQSIRVRSYFAGELQNSVTGLFDKIYDRGDGAVVCLDMVVLERGLWQSEQTRKHCEEELFQLFIAKLMESGHDHDGRSLKGIARLLVVDAGSLKHLVDEEGFDVIVSSLDRRLPADVKSQATLATAKYLEVSGDAGQTLCSNFIKTRVAKHRKGDYIVAFSAASVVFPILPEFAVSLFLTEGFLKSLTPLLARKIKCKNLELAILELFNAACVNSSCREAISKNFVDWLSEHLKSEAEETTALAAVVLAKLSVSPKDASSADKDKAGIVQEEHADPLELVDKFKTMLGKSGQDGNLRHVVEGLAYASVKAEVKEQLAQDSKFLQDLISLLLERVADSTVLYGGLMIIHNITAYRPNMSEEQKKMSELKAYANASKPRATANPLEDDDHTKARCSAIVNAGVMPLLVECGKSQLASPKDLVNKILLSLSKDSKSRGKLAQQGAVKLLISSVSSQDSTATHTPTTESTITNGAHALARILISVNPSHVFPSSGFPQITSAIRPLNILLTPPGTTSISSDQPRDLLPVFESLLALTNLASYPDQSVSTSIIRSAWSTIEDLLLSHHTYIQRAACELVCNLMSCEAGVGKFADGTHRASQRMHILLALADVDDMPTRSAAGGALAMLTDFEGAASAIVERTRGVDIILNLCQEDDDGLVHRGIVCVHNMVGGTGDIGRKARKAIREKHGMEVLRDCLTKTKNPAVMRSGVEALKKLVDCQASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG17</accession>
    <name>D4DG17_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_06119</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019831.1">
        <property type="nucleotide sequence ID" value="XM_003019785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG17"/>
    <dbReference type="MEROPS" id="M41.003"/>
    <dbReference type="GeneID" id="9584582"/>
    <dbReference type="KEGG" id="tve:TRV_06119"/>
    <dbReference type="HOGENOM" id="CLU_000688_23_4_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="539"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="951"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="979"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="995" mass="110148" checksum="C27D9395EC93A384" modified="2010-05-18" version="1">MSQQLAKNSEQEQLAKLNRFGNHLDFISVLHQPRSLFPLCLARGSSLVVSKSCFVDCGFVLSELVSRTLTDLIDCLPPSCSALAMATLLRRPGGLAQYSRRAAGYSAFSRTPFSASLPQSRLSAFIVANRSRLYATNSTGGSEHPKDKKNGEKDIGKQAERSSQSQSSGSQTSESSQSKYALNAEQREEFDKIVDQLKVNLPKSQAKLIDTAAEVIKREGLPEEVKNALEEVRESKHISLSNAAKLVRVLNKHSVKLASSVADEHSKNSSEEQRKDNKAPTEEKPKEESNEGRKEESREGSKEESKSDKKRQRNDDKDQPKGPQFRIMDFKFDAGNFLIAAFISYYVYRSIFPGESSRDITWQEFRNTFFDKGLVEKLTVVNRSKVRVELDRDAVAKLYPESPATNMSFHYYFTIGSVEAFERRLDDAHRELNIPSSERIPVAYADEVPWLATLLSFGPTLLLIGSFFWLSRRAGGAGGGGQSGIFGIGKSRARKFNHETDVKTKFADVAGMDEAKVEIMEFVSFLKRPEQFQRLGAKIPRGAILSGPPGTGKTLLAKATAGESAVPFYSVSGSEFVEMFVGVGPSRVRDLFATARKNTPCIIFIDEIDAIGKSRSKSNFGGGNDERESTLNQILTEMDGFNTSEQVVVLAGTNRPDVLDKALMRPGRFDRHIAIDKPTMDGRKQIFGVHLKKIVTKEDIEYLKGRLAALTPGFSGADIANCVNEAALVAARMHADHVVMSHFEQAIERVVGGLEKKSLVLSPEEKRTVAYHEAGHAICGWYFKYADPLLKVSIIPRGQGALGYAQYLPAQGDTYLMNVHQLMDRMAMTLGGRVSEELHFDTVTSGASDDFNKVTRLATAMVTKFGMSPKIGTVYFEEDQQQLHKPFSEETARNIDMEVRRLVDEAYKQCRDLLTEKKAEVGLVAEELLSKEVLSRDDMIRLLGKRPYPESGEFAKYFDGTGGKIQPPPPAETLTGSPKADDAETKDNKPSSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGF0</accession>
    <name>D4DGF0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000354">
        <property type="protein sequence ID" value="EFE39066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019711.1">
        <property type="nucleotide sequence ID" value="XM_003019665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGF0"/>
    <dbReference type="GeneID" id="9583618"/>
    <dbReference type="KEGG" id="tve:TRV_06253"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="43375" checksum="E19B1E5A4A6C9584" modified="2010-05-18" version="1">MAPRIAVPEEVQRRKIIGINPETVTNPSATDFPSHWPGENHAWSIDKFTPYSPPWKLKGLKIEFHKNDPLEASFSLIGVDAAIANAFRRILLAEIPALAIEYVYIQNNTSVIQDEVLAHRLGLIPLKGSLEGLNWLRWFKIPKEGDPDSGSTHEDSNTIVLRLVKECTKNRNAAPDEEDPTVLYNNAHIYAKDLVFEPQGRQEKYFHGDGVIQPCNPDILLAKLRPGQKIDIEMHCIKGIGADHAKFSPVATASYRLLPDIKILRPILGNDAIKFASCFPRGVIGIENVTAAEAAQVGSGYEGKEGEKKAVVVDPFKDTVSRECLRHDEFKDKVKLGRVRDHFIFNIESTGQFNSDLMFLESIKVLKLKCQRLKRNVATLADNTDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGH1</accession>
    <name>D4DGH1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000357">
        <property type="protein sequence ID" value="EFE39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019695.1">
        <property type="nucleotide sequence ID" value="XM_003019649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583597"/>
    <dbReference type="KEGG" id="tve:TRV_06275"/>
    <dbReference type="HOGENOM" id="CLU_003925_0_0_1"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000632">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="910"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1211"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="809"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="813"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1402" mass="156210" checksum="B20074CA2C7F6FB3" modified="2010-05-18" version="1">MGPRGGGSVLKTPLHSLSSLPFSLLLLPSCSSSFSLSLSLLSVLSSTAAAARRATTADSAAMDIRDLITPNSSRQEKAVRSPAPVPSPRPRSHRGNTPQTAWAGSGGVHGNGTGPRQTQSQAQPQAQAQTQTQTQASQTPQAQIHTPNSARGPQTPSTPGIDALVEAAHIKRAEPSPSTAFPIVPPAAAQHNTPTPRPSGYDGAAEPVADAPRRDFSSTCLSPEAQQTAAQLYSNIQKNHYAYEDRVNFIRLLHQGFVDHIYPPASPDSHGDPHRFDVLKDLKAAREELDSLFAIGEDLWAEWIQDESLLARTVNERIAVMELCRRSVEEEYGSTKLWVIYGEWMLYLYKASAGDRDGSGRGHWSDEDRIIGREVFTWQSVVEVWKAGADATKWRINDCHLVWNRYLELLMQDVDASPSQERVSQLRVLFESRLQTPHAGWDDTFQLFSNFVSKYYNANYEDLMVDARSKAAEAKAMYAARETREAALHRTIELKDTNAEWTTFQEYLDWELSKPQRRKGQQQQQQLQPLRLELITSLYQRAVLRFPTDATLWEDYVMFLIDESMDGPMGVSPIPVIERATRHCPWSGALWSQLFISAERAGLSFAEILELKHKATRSGLLDAAGINEVLKVHTTWCSYLRRWALQPESTDEDLDVAEVGIRSAIESVQELGDKTDKAVPNDPLFHLERIYIRYLSARGSWDSAREEFKHLIPRHGHSFEFWLAYYTWELLSWSKFMPCDSSASASRRMPNPSYATAVLKQALQRTDLDWPEKIMDAYISHCEHYEDADESQLAIIDVRKAMKALTKRRQREALQQQQQQQQQQQQQQYHHHQQLANHQYHQVQHAQHAPVSVGPHPDSVEQQYHYPDETQLAGKRKREGEPEVNGTVSKRAKGGAIPSVETRARDREHASVIIKNLPKDIPQVKIRQFFRDCGKLNSLQMLPGDSGSALLEFDTHEDALAAGTKNQKVLEGNQVTVEPVTDTTIFVTNFPPTADENYIRELFHSYGEIAEVRFPSLKFNTHRRFCYVQFTSSSSAYAATELDKKDLGDGLELVVKISDPSQRQARSGAYEEGREIYVCNIPYKTTEGDLVELFTAYGDVESVRIPTKVNGETRGFGFVTFATKLDRAVILTSDKDQSTAALAMNEKTFKGRELNVRLSTNTGAKRHQNTIVSRSESPATNAQRNGTSTASPPPGSLPDGQSKGKGDRHLRTLGLMNIPDTVNDTRIHALAEPHGVLVKINLRPDHQGAIIEYADTHDAGKASLALEGYEITPGRFIHVGSVKEMLQQKAEHKIDRIPIGKEKGKVSGATTSGSGTTGGSKMMTQPSAPIRRPNQSSGSGRRGGLGVKRGGSGIPSRDKPPGSTTNHHDDTDGQKSNQKQSEPTTTRNKTNDDFRAMLSQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ6</accession>
    <name>D4DGJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6 finger domain transcription factor nscR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Neosartiricin B biosynthesis protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019671.1">
        <property type="nucleotide sequence ID" value="XM_003019625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ6"/>
    <dbReference type="GeneID" id="9583559"/>
    <dbReference type="KEGG" id="tve:TRV_06300"/>
    <dbReference type="HOGENOM" id="CLU_004083_9_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1068" mass="119992" checksum="800D36066EF8F22C" modified="2010-05-18" version="1">MDPLGYSSSHLHPNSSSAPAASHSPSPTPSIHLSPAELHQVPTVGGSSNTTEDASNGSQQYRQYLSGTSTWGGQDVGNTGGDDGSHQGSATTTASKKQAQQQTATMKIRRRNRMITSCLECRRRKLKCDRLHPCTNCSKFKRHCLFLSPTTDALSRMKLMELKEKMGSLELVLEQDVAARQTGQTGHDDPSSNMNANTPAPVSGFVSGVVEYTRNDRKPEGSFDLDTLEILDNLEHDRGDPVPDDEKYLRPTPLAVMDAAYDDDADDDTFDIGFKLGKMRMTDRLGGFFRPRIADEISVVLKEPRVSNGVTDTSLNTPVKVPEMKPPRLRDLMPEGQESCFHPGPTYIAPHSDFFFGGGRRTSLADFLPTRNASDRLLEQYWVSVDPVAKILHRPTFERQYWEFWSDVSKSLEPAYSLQAVVFAVLFTAVASMQEHLVLSTFGVAQKKLIENFQLGTEMALGKAHFLKTTKTQTLQALVMYMIPMCRNEVSRTHSALVGTAIRLAECMGIHRDPEEYGHGPVETHIRRMIWYQLCFLDLRTSESQGPRQTIRREDYSTKFPLNVNDADFLQHRGSRLTDMPKFTDMTFTRIRFECHELHRLVYVDRMKLETNSISLTRVLGKIEAFRRATYAKYGPLIYVSNPKPIQRAAQLVLSILICRSYTAVLHRYHNSVSVRIPDRLRQIIITACTQILEDAIELETAPDLQPWAWYSGAFNQYHVAFLILMEVWAYPMRKEADRIWRCLDYVFETPSTPAIPGTAGKNARHQLIMQRDRKARLILEQLRDRMEAYREMRKLRVPISMADTKVLRMTPEVGTSREPSPPQTTEQNSAGGSLQWGPQYTSQPFEESQTIPAPSSQPVNPSRVSPPRMFSHEQYQIQSQQGRRLSPASLMQQYQHGQPSYQRLQSQPQHSSALPPTSSSYSSSPAYNPTFQHQGYTPDYSTRMPGRESLDSGTGSEDSGMGHLWFASGFDNTNTGAGLAPPLHSAPQRPSAITAKLNNTEEDLPMLDIDWNEWDKLFPPDINNGELNLPPLSPMVGPTDTTASLDNISSLAETTNSNYSTYPYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGK7</accession>
    <name>D4DGK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019682.1">
        <property type="nucleotide sequence ID" value="XM_003019636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGK7"/>
    <dbReference type="GeneID" id="9583570"/>
    <dbReference type="KEGG" id="tve:TRV_06311"/>
    <dbReference type="HOGENOM" id="CLU_1120802_0_0_1"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28267" checksum="451385EA6A8A8502" modified="2010-05-18" version="1">MVLTAEFRVQYLVYMGYIDNAFSIPPGLHLSWHLQKYNCKRRPFEYKRPLLSFTKQASIYSSSSPLSSISETLSLQIYSFTAISPVITTKMGYPTNAEIKSLLESQFHSKLQKSDLTDDSESLFQFGHLDELFSDDVEVHISGHEFHLNGKHRGLDAFKEHLQSDDMPSLNSIIDVNKPIKGSVLHVIGGENDEWKAAVLHSTATTQNNTPWNHEMAVLMRFNHDGKITELRAYADTQHVHQHIEAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGN4</accession>
    <name>D4DGN4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019621.1">
        <property type="nucleotide sequence ID" value="XM_003019575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGN4"/>
    <dbReference type="GeneID" id="9580151"/>
    <dbReference type="KEGG" id="tve:TRV_06339"/>
    <dbReference type="HOGENOM" id="CLU_009663_0_0_1"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="794" mass="87043" checksum="02A65B27325E5E58" modified="2010-05-18" version="1">MLATRSVAGRFFHSSLWPRILRSDSASTTGLPRSIVFITLLSTITTILFGLTATVTPLGLYEGVSPRKDTKLVDFHYIKDTSPIGYGTPARGNVRFSRICGGFTPQVCPHSNGNLTSTENSTGEHVSGDWYDTRIPQRVIDMFQSGLSSQQSSVSSIFDIQWRSYTYSRIEDRPDNLVVDNGTRYPVGAFRQISTFVLNNRIEAVEGLVVDTKNGGIGFRNHTAPPVEPFGSSWSEDLLFIVPETQCVDTNLTLDFSIPLKNSESISNQISNLVLTDRGGFANLIQKYPSWDRNDTQRNPDLRNRAYKAAWINNVWSMAFMNVTNFRNESDPKSKAFSYLDSFVGKKFPLQSDHSSSTTLLIEPDSIITNSLFGYYLSGTDLAINGTNLTSSHITTPNKPHLFSNPWKIDSLNFSSASLLCTGLGGLDLANITNIAARCGLQYGAPQRVGAGESLIFDPGSSWTVPMYSCASTIKAIIKTVDFRFNGTEDNLSSLTVMGIREKEYPNEESKPLWAVENTTMRLRDVRSLWGLVTPESVIGDQNISTIRKESLYLPGGDSSSLGSIDSQNLPGLNFHSDALGVAYGDGSSSFSENYNGKNQLAMYRLWQELSRNASTVGKIKDLIWTDVALNAVTGTRSISPDGYNKQVLAKRDGDQADKAKRIPVTIYERRVHYKYRYGVLAFISLALIAAVFSTLILLCVLRRTGFSKARKYLDETSVGRILAARTTSSGGPGVHRAPTNTWVKTTGKAPITLGSSQPPNNGPNSTSAILYPGGSALAASADKIEQSSYLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGV8</accession>
    <name>D4DGV8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019539.1">
        <property type="nucleotide sequence ID" value="XM_003019493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGV8"/>
    <dbReference type="GeneID" id="9578313"/>
    <dbReference type="KEGG" id="tve:TRV_06413"/>
    <dbReference type="HOGENOM" id="CLU_090026_0_0_1"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055568" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20686" checksum="EB8BCC1BA4E6D5C1" modified="2010-05-18" version="1">MKLTALFVSAAAVVLAAPTANLNNPEIEARNTQFVSPKDTFLHYINTGITNHDVYGRPLVVKNGKAAEETSAVVTFDFDGSYNGRRCRLRFDTSAGDISKGSQQLDVYSVINPPTWPIQSPFSRDQHRGRIYVLVSGTAQWVQGYNGYPEFDCPVNKRIGYEFVGVYDYDIIDWNVGSTGPRIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGX4</accession>
    <name>D4DGX4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019555.1">
        <property type="nucleotide sequence ID" value="XM_003019509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGX4"/>
    <dbReference type="GeneID" id="9578329"/>
    <dbReference type="KEGG" id="tve:TRV_06429"/>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="310" mass="32356" checksum="229B2FFE177351E1" modified="2010-05-18" version="1">MAFGAPRGRGGDRGGRGGRGGRGGARGGGRGGFGGRGGGDRGGRGGGRGAARGRGAGRGGRGGKAGARGGAKVIVEPHRHGGVFVARGGKEDLLVTKNITPGESVYGEKRISVEGPSTGDEPATKVEYRVWNPFRSKLAAGILGGLDDIYMKPGSKVLYLGAASGTSVSHVAEIVGPTGTVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVGMVDVIFADVAQPDQARIVGLNAHLFLKTGGGVIVSVKANCIDSTAKPEVVFAREVQKMRDEKIKPKEQLTLEPFERDHCIVAGIYRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGY0</accession>
    <name>D4DGY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="8">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAN3</name>
        <name evidence="11" type="ORF">TRV_06435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019561.1">
        <property type="nucleotide sequence ID" value="XM_003019515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGY0"/>
    <dbReference type="GeneID" id="9578335"/>
    <dbReference type="KEGG" id="tve:TRV_06435"/>
    <dbReference type="HOGENOM" id="CLU_016423_1_0_1"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="10">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="8">
        <location>
            <begin position="658"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="494"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="798" mass="87978" checksum="A45A7DE25F01D111" modified="2010-05-18" version="1">MASIAKPGLEDGRRTNGSPKLKGRVVENAKDTLCRNVTIYGRCRYEDKGVQLDRLRSLARQQTSPAQPDPNSQTLPLKATMDSSCLASSSSGAGVKQKRLNVESPSFTPSTTPNNGTAPTSAVTAKKPATLSPKAAGAAPFLPKGSLSRANSGISQLRQETGTPEWGLTDVPDFVPQRFDTVVCCLFQFQLIIGTGPFTKVLIAQDSMQATNNGVLATGNAYDPFVSTTTPLATAGAVVTHPLQPNPYAHDHTGIGPTSYFTAQSTFQQPAQYHLYAPIGPHNQNILGYQRNVHDLFIPNDFREELQKKAAATLQTLPSTFINCYILFRVCFTDCWLDSQLPTQIDHFHSLVPLDVTHQKNATIFGYPSWVYKAQSSKDGNYYVLRRLEEESKANFFKRLPVNKRKGNQMRAGMEKGHLCQRGDGARCLYQPQLPGQLPDLRDGLPPAVQDAGRAAPGKPHAVPEPAREHACNRACALGAIHSAGLAARVIDASKILLTGKNRIRLNACAILDVVQHDTQRSIADLQSNDMVSFGQLILTLGASSLAHNPTKALEHFSRAYSAQLYNSVLWLLGAGPSKEPQGQLQPANQSQNPNANANPNANQGSDRTIDVFITGISTQLISTFDSSLHVDDELTHDLSRELENARLVRLLTKLNFITERPEYDHDRHWSENGERYFLKLFRDYVFHQVDSQNAPVVDLGHVLTCLNKLDAGSEEKVTLISRDEQSCFVVSYKELKKGVEMSFQALMKRREEWVDGWMAVGIWQLFVLYISDPPGTDLAFDSASAYIKNESTTYQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ5</accession>
    <name>D4DGZ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000365">
        <property type="protein sequence ID" value="EFE38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019525.1">
        <property type="nucleotide sequence ID" value="XM_003019479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ5"/>
    <dbReference type="GeneID" id="9578218"/>
    <dbReference type="KEGG" id="tve:TRV_06450"/>
    <dbReference type="HOGENOM" id="CLU_1566707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="19141" checksum="8EBB5A24B3A5AB91" modified="2010-05-18" version="1" fragment="single">LLAPSERAEHRIIEQASGRSKDAESGNKQQDTLAFFSSGQAISLMGSFSVRPEFAFLPYPPPSPPQLDQIRIGPFKRLAPVILLFLTILRCEGGWDFLDPQKLIAMGSRRWWPLDGVRYQTRVCLLMHIILACLCPQYQLEASFANGIPSSVTFSQFGLHQPIYHTPLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH07</accession>
    <name>D4DH07_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000367">
        <property type="protein sequence ID" value="EFE38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019507.1">
        <property type="nucleotide sequence ID" value="XM_003019461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH07"/>
    <dbReference type="GeneID" id="9578198"/>
    <dbReference type="KEGG" id="tve:TRV_06462"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="38716" checksum="5691D28447ABD853" modified="2010-05-18" version="1">MATVQSDIFKPTKYGGKYTVTLIPGDGIGVEVAESVKTIFKADNVPIEWEQVDVSGVDSGNKHSEDLFRESIASLRRNKLGLKGILHTPIERSGHQSFNVALRQELDIYASIVLIKNIPGYQTRHNNVDLCIIRENTEGEYSGLEHQPVNGVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRSTFKKVAENYPTLETNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNVAAALVGGPGIVPGCNMGRDVAVFEPGCRHVGLDIQGKDQANPTALILSGSMLLRHLGLDDHANRISKAVYDVIGEGAVRTRDMGGQATTHEFTRAVLDKMEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHC5</accession>
    <name>D4DHC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019414.1">
        <property type="nucleotide sequence ID" value="XM_003019368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHC5"/>
    <dbReference type="GeneID" id="9580130"/>
    <dbReference type="KEGG" id="tve:TRV_06581"/>
    <dbReference type="HOGENOM" id="CLU_065200_0_0_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="296" mass="33087" checksum="1E1632970270503B" modified="2010-05-18" version="1">MSSLRNTIKPAMSEPAGTSPMEGAYKQHTHTPHLESDYSYDSEDSTDINGARREVDRSNLPGGNRSLAGISIRSFLLGQAAGLCSLLTLILAYHSHPLWRAPFFITCLAVFHFLEFYITAAYSTSFATVSAFLLSSNGAAYNIAHSSAMAECLLSHLLFPEGYLQWTSMLFGGVRVQVFVGLMMVVVGQIIRSFAMVQAGSNFTHTVQTQRRDEHVLVKSGLYSILRHPSYFGFFWWGLGTQLVLGNFVCFIGYALVLWKFFSSRIYREEKLLIGFFGNDYVEYKSKSWVGIPFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI44</accession>
    <name>D4DI44_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000394">
        <property type="protein sequence ID" value="EFE38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019128.1">
        <property type="nucleotide sequence ID" value="XM_003019082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI44"/>
    <dbReference type="GeneID" id="9582613"/>
    <dbReference type="KEGG" id="tve:TRV_06852"/>
    <dbReference type="HOGENOM" id="CLU_070130_0_0_1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="284" mass="31030" checksum="C99F252967240CE7" modified="2010-05-18" version="1">MATSTAPSSFTLPGSEPPVAVQLTPDISQAQLLSFPAFKIWLSTLRHSLSRQSNASHEFHVKPYALRGITVQAVDYFGAKKLGFIKFKADVSTDDGDRLPGSVFLRGGSVGMLLILQPDDLPASSNDEKHVVLTVQPRIPAGSLTFTELPAGMIDEHGSFAGAAAKEIHEETGLTIKQDELVDMSSLTLLNKDKDTDQDETLQNAVYPSPGGCDEFVPLFLCEKRLPRKDIQQMQGKLTGLRKEGEMITLKLVPLSRLWQEAARDAKALSAWALYQGLKQDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI60</accession>
    <name>D4DI60_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nudix/MutT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019089.1">
        <property type="nucleotide sequence ID" value="XM_003019043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI60"/>
    <dbReference type="GeneID" id="9582594"/>
    <dbReference type="KEGG" id="tve:TRV_06868"/>
    <dbReference type="HOGENOM" id="CLU_743075_0_0_1"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="237"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="41352" checksum="AF1B67637B1E9AB0" modified="2010-05-18" version="1" fragment="single">KKEKDEKDEKDGGVKVKKKKKRRRREERSRRAGWESSPRGKEEEEKATIKEKEEKKKKEQEKTPERDAIIPESILRASIPESIPSHPVQSRVHPPVWHRLRLASSVRRPRLRFPGACLSLLSPSAGSAGSSYYVVDCASPYSAFTSARPRPRPLRNLLYSASSTLPLLLYSSAALLPLYGCCFFYSAPPTPACPACPSCSLCLYYGDSHDGSPNWPDKPATTLTASSSSSPGYSPAGERLVAGVVPLSPDKSKVLLIQSARPGAWVLPKGGWELDEPSAQVAAVREAWEEAGVVCTVTSDLGKIPDMRSATQISAKAPRVLYQFFEVRVDREESQWPEMHKRKRQWVTYSQAAAALVARPELLDALNRSSIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIF5</accession>
    <name>D4DIF5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase (PrpD), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018952.1">
        <property type="nucleotide sequence ID" value="XM_003018906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIF5"/>
    <dbReference type="GeneID" id="9582112"/>
    <dbReference type="KEGG" id="tve:TRV_06963"/>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_1"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="273"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="473" mass="52713" checksum="D8BF71CECCB04D9D" modified="2010-05-18" version="1">MASYIHKHEIKSDLAFDTARWVFLDTLGCGLEGLKFAECTKLLGPIVPGTTVPNGTRVPGTPYQLDPVNGAFNIGAMIRWLDYNDCWLAAEWGHPSDNLGGILAVADWISRTNRAGGSLANGKVLKIRDVLEAMIKAHEIQGVLALENSYNKVGLDHVVLVKVATTAVVSKLMGLTERQTADAITQAWVDGQSLRTYRHSPNTMSRKSWAAGDACQRAVNLVLKVQKGEPGVPTVLSAPVWGFYDVLFKGNKFAFQREYDSYVMENVLFKVSYPAEFHSQTAIEAATKVNATLKSMGKSAEDIKEVTIRTHEACVRIIDKQFKPMDNFADRDHCIQYMVATMLTFNRLVASDYTDGSEAATSPLVESLRTRIRCVEDPQMTKDYHDPALRTIPNALTVTLNDGTVLDEVVVDAPLGHRLRREEAKPEILAKYKRHLEGHFDAQRVKQLIDLGLEQKTLEEMDVDKYVDLYVKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIT1</accession>
    <name>MEP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable extracellular metalloproteinase 5</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fungalysin MEP5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEP5</name>
        <name type="ORF">TRV_07092</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase probably acting as a virulence factor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="ACYE01000412">
        <property type="protein sequence ID" value="EFE38255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018900.1">
        <property type="nucleotide sequence ID" value="XM_003018854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIT1"/>
    <dbReference type="SMR" id="D4DIT1"/>
    <dbReference type="MEROPS" id="M36.001"/>
    <dbReference type="GlyCosmos" id="D4DIT1">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9580072"/>
    <dbReference type="KEGG" id="tve:TRV_07092"/>
    <dbReference type="HOGENOM" id="CLU_012703_3_0_1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397740" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397741" description="Probable extracellular metalloproteinase 5">
        <location>
            <begin position="245"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="633" mass="69756" checksum="4E7DDF2002687C1E" modified="2010-05-18" version="1" precursor="true">MHGLLLAAAGLLSLPLHVLAHPQPSTNLAGRGVDLDAYRMADRSSYMSSDDMKLKQPAIASLSGGNYVDTATEVVKRMMPGMTFRMVDDHYVGESGISHVYFRQTMHGMDIDNADFNVNIGKDGKVLSVGHSFYTGPAPDKAPVEKRDFSDPMQAFHGACKALNLSINSDKATIQTMNEHEVMFMGTSGAMSDPQGKLCYMAKEDGTLALTWRVETDMGDNWLLSYVDAKETDKVHNVVDYVSHATYQVYKWPIPDPTEGKREIVENPWNLKTSPFTWISDGKTNYTTTRGNNAIAQANFDGGEDYLNNYRPDSKNLKFEYPYAPNMSPPKSYIDASVTQLFYSANMVHDLYYMLGFTEKAGNFQVNNHGQGGKGNDFVILNAQDGSGTNNANFATPPDGKPGRMRVYIWTKAKPSRGSSFEAGTVIHEYTHGLSNRLCGGPANAGCLNGMESGGMGEGWGDFFATAIRLKPNDNRNSNYVHGEWVNNSPKGNRLYPYSTNLQTNPLVYTSCNKYNEVHAIGTVWCSILYEVLWNLIDKHGKNDGPTPVFENGVPNDGKYLALKLVLDGMAIQPCKPTFVQARDAIIDADMNLTKGSNKCELWKAFAKRGLGVGAKYDPKNRTGSKAVPKECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIW8</accession>
    <name>D4DIW8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018861.1">
        <property type="nucleotide sequence ID" value="XM_003018815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIW8"/>
    <dbReference type="GeneID" id="9581505"/>
    <dbReference type="KEGG" id="tve:TRV_07129"/>
    <dbReference type="HOGENOM" id="CLU_036094_0_1_1"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="47515" checksum="D3198B5D39CF7545" modified="2010-05-18" version="1">MTDTVSTMPIASSAEEQLLTANRDKKPRWSIIEKAERSHRRVPGLRKIPLPALAIIFFIALINILVWIAAGIVLHQQLLLHIALVYVMLSMRIIYHIVIITSIVVAATAAAVSDKFDKYGSIGGIIGSSVSSAFLILLGIMNGYILYKLVLQMKKVLRDKNKGEEMWKIEGGGILFSILKGMFKIIDRPWKMYPLGVLFGLGFDTSSEIALLGISSVQASKGTSIWLILILPILFTAGMCLIDTIDGALMLSLYVQPAAHFLDSKSQPSAEISAAPIPPETPKPQSTPVEEPVSRNPRDPVAFLYYSIVLTSLTVVVAIVIGVIQLLTLLLNALKPHGKFWDGVQVAGDYYDVIGGAICGLFIIFGGISVLVYPQWRRWAGKNQDSAPSCGHHVSQADEESRIDGLDVAVTNTQSLSQAGENPVDSPKTGTAADTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIZ4</accession>
    <name>D4DIZ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000417">
        <property type="protein sequence ID" value="EFE38193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018838.1">
        <property type="nucleotide sequence ID" value="XM_003018792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIZ4"/>
    <dbReference type="GeneID" id="9581482"/>
    <dbReference type="KEGG" id="tve:TRV_07158"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="95"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="455" mass="52094" checksum="B3AE2902CCE2C328" modified="2010-05-18" version="1">MINTLHLTRLSAYSRPITWQLPVYPATRTRRFLWTSISSSLKSFLPKLPERRRLFPTNGFQVVDSNIAIEEEAIPDYKADRFYPVKLGEVFEGRFQVIAKLGFGSSSTIWLARDLRHVSPHSLCLKYLAVITLSNCCRRHEYVALKVYMHTSKYLREPPFYDHISRHLTNTKSQYERQNIRRVLSTFQLAGPHGIHPVLVCEASQMSLRDMKTVFFPNGFEESFVKAATIELLKAVEFSSTPAQGSFTPVYIHPGNLLLGLYDNNVLQVLEKMEFDSPVPRKPVSDSRTIYMSRLGKPKEGPMLLSDFGEARIGPGPHGGDIMPLEFRAPEVLLYVGWSYPVDIWSVGLTRLFTARDEEDGQAYDAVHFAEMIAALGPPPAEFLAKNPERRADFWGEKGEWLELAPIPEGRTLESVENRLENNEKFLKFIRRALTWMPEERPTAKELMQDPWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ35</accession>
    <name>D4DJ35_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018765.1">
        <property type="nucleotide sequence ID" value="XM_003018719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ35"/>
    <dbReference type="GeneID" id="9581180"/>
    <dbReference type="KEGG" id="tve:TRV_07200"/>
    <dbReference type="HOGENOM" id="CLU_110343_0_0_1"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="156" mass="17017" checksum="CE25C89317FAF86C" modified="2010-05-18" version="1">MIVQFQSDGEETTSNAGVVAADEVEVSANATAGSSMSVLDALKGVLKIALIHDGLARGLREAAKALDRRQAHMCVLNEGCEEEAYKKLVIALCSEHKIPLIKVLDGKMLGEWVGLCVLDREGNPRKVVNCSCVVLKDWGEESQERSILLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ42</accession>
    <name>D4DJ42_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018772.1">
        <property type="nucleotide sequence ID" value="XM_003018726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ42"/>
    <dbReference type="GeneID" id="9581168"/>
    <dbReference type="KEGG" id="tve:TRV_07207"/>
    <dbReference type="HOGENOM" id="CLU_083361_0_0_1"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="188" mass="21008" checksum="7ADA59017587BC11" modified="2010-05-18" version="1">MSIHHPAIAPSAVTTLISSQPQTPPPHVALSLEILHNLEHQHQWKDLEIHEPFSLSQKQSIPLISGTPPQPIYIHPDEQAYLLEHNIPMKDIPADREWVIPTAQGEKWTLSRLAGLHDSLPSRAEDFLPGSVDLEEATKSMQEYVKLKKEKPWGGKRALLAMVNRGLGGDGTVVYYVTMEGTPKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI2</accession>
    <name>D4DJI2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018660.1">
        <property type="nucleotide sequence ID" value="XM_003018614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI2"/>
    <dbReference type="GeneID" id="9580813"/>
    <dbReference type="KEGG" id="tve:TRV_07350"/>
    <dbReference type="HOGENOM" id="CLU_019525_0_0_1"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="2">
        <location>
            <begin position="280"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="607" mass="67889" checksum="6F4EDAF8828FCBFA" modified="2010-05-18" version="1">MADLDAELLALAGGDDSSDEESPAISQQKDKDKGRQASPGSSSSNDQDDDADNMGRKGVARPVKRQRKRARAYDDEEEEGELSSSSVHSRRSLRSASMSESESDTSPPPEENQGPIFPYEKLFYSAKDKSEIMALPEIQREELLSERAQQVDRHNQDIALRRLLANREREEARAAAKKKRKAGSADLEDSQRKSSRKKTVLGGRKVGEPSDAIEAYKRQREQKGKRDEQRRRDASSRKNNNASSSPAREADDRDASGESEVEWDDKPQRRSVSPPRYDPPAELRELQRARIARSNFAQVCFYPGFDQAISNCYTRVSLGPNLSTGKPEYRIGLIKTEKEFPFIACSESPFTEAEFNRYRKTMAVDGLKMPTKSAVDKKVADINRLLAHDFTKEELEEKLRRQGTNDNKQLIYNRIQLERRRNEAIANKDEAAIAECDAELARLTGPKLAFGTTLVKPRPNEKTQQERLAELNMRNQKLNTENVRKAQLAERKAAKLAAAAVARGEAVADRFARVKTRARTYYESTDGHLVPVKPEAAIADRSRAITPTTASNNTDATNTPANGTTPRSVTPSKPATPKVYKGVPVIRHRPTDEDNIAALDLDIDIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJU6</accession>
    <name>D4DJU6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018518.1">
        <property type="nucleotide sequence ID" value="XM_003018472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJU6"/>
    <dbReference type="GeneID" id="9584447"/>
    <dbReference type="KEGG" id="tve:TRV_07464"/>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="18043" checksum="255B4519FAF12832" modified="2010-05-18" version="1">MTLFCKTVAERTRPGQRQDIEEKSYTFHVYGRSEGIAGVIISDADYPALVAHQLLSKIVDEFLVKHPRTSFIGKEISGPLDFPELKEYIVKYQDPTQADSIMKIQKELDETKIVLHKTIESVLERGEKIDSLVAKSDGLSAQSKMFYGQAKKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJW2</accession>
    <name>D4DJW2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018534.1">
        <property type="nucleotide sequence ID" value="XM_003018488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJW2"/>
    <dbReference type="GeneID" id="9584463"/>
    <dbReference type="KEGG" id="tve:TRV_07480"/>
    <dbReference type="HOGENOM" id="CLU_2160244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="111" mass="12176" checksum="8E37861E584A948F" modified="2010-05-18" version="1">MGYWTDVVPQWAWILMFWVIFLTLSNLGVLTYGEVEFWLALIKVISLTIFLILATIISAGGIGGKTIGFKYWSNPGAFADSINGVAKTFVIAGTLYAGTEMYDAPSTLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKC5</accession>
    <name>D4DKC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000464">
        <property type="protein sequence ID" value="EFE37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018341.1">
        <property type="nucleotide sequence ID" value="XM_003018295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKC5"/>
    <dbReference type="GeneID" id="9580039"/>
    <dbReference type="KEGG" id="tve:TRV_07647"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_1_1"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000475">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="484" mass="53291" checksum="9377D088746FF83B" modified="2010-05-18" version="1">MSSPGDTPSSQPSMTKLEILPTIGENNLQALLEEHGLEYTPDGEHIRWLASNPKHPRNWSMLRKIYDSGLIIILDLFTTAVSTAGPFTLIIDLLSWKTRYLLGQGVGGIIFPPYSESFGRKKLYIVSTGLYSLFCVVVGLVPSVAGVIVGRFFSGFLSAIPTIVVAGSIEDIFNSKDRIWLIFMWAMVANMGLILGPIMSIYIIDHLDWPSLLLSREVAKLQKSTGITTLKALNPDHTPDMKTFARIALFRPLKLFFTEPIVFMVATISAVAFALIYLFTEALPPIYEDLGFSSANSSLPFLAIGIGLISGVLTRIFDHRMITRYQREGKVLQPEHKLVGFSIGAPVLAVGLWWFAWTIPPRVPGVHWVVSAISLVLIGYALNEFDAVLAGYLADSYLSYSASGFAALSLVRSTLSAVFPLFAGRMYEVLGANLATSILAALATAFCIIPPLFTRYGPRIRARSKFARYSLQVYQENGVDKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKS5</accession>
    <name>D4DKS5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis protein MEI2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000480">
        <property type="protein sequence ID" value="EFE37551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018196.1">
        <property type="nucleotide sequence ID" value="XM_003018150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKS5"/>
    <dbReference type="GeneID" id="9579565"/>
    <dbReference type="KEGG" id="tve:TRV_07799"/>
    <dbReference type="HOGENOM" id="CLU_019467_1_0_1"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="1">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="434" mass="48692" checksum="B3232130547AF396" modified="2010-05-18" version="1">MSSPTFIQDQNPANLADLTKTSVPDTPGLVSAFTPRGSVDFGPIGGARVSPPSSASSKYIPAPYAMYYQQGHFDAENRNRAFVIEGVPVDMPYHDIAAIFNHREFNTVKGPVLSELASHGRIYVGFTDIYEAKMAAVKAKSFFPSWRFHALTAKEFTQKFEPSLAPTTSDYEGQIFATVYYNGGPEETDGRIISHSFKTLLSTYGEIKAFHSIPTDHNNIVNFHVEFSDTRAADNVVSGLNGSSLPECVIDVKYFKPDVTYHAHAHHPVEEPVPRTSPIIMHDRTIPMARRRSFASPNPYMELSPTGRSTIPIGDPAVATWNRRSDECHNFRSRHGSGRNRNSTHNNMNQNHVDIERIRLGLDVRTTVSVFLFPFPMHCLTFELIQIMLRNIPNKIDQAMLKDIVDETSHGKYDFMYLRIGKKPTFLSSSVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKW2</accession>
    <name>D4DKW2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018140.1">
        <property type="nucleotide sequence ID" value="XM_003018094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKW2"/>
    <dbReference type="GeneID" id="9579349"/>
    <dbReference type="KEGG" id="tve:TRV_07836"/>
    <dbReference type="HOGENOM" id="CLU_934435_0_0_1"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="31883" checksum="B44597072B76F02C" modified="2010-05-18" version="1">MADAVEDYCSPSVLPPQSTTSPSTSRRQQSNMSLSQTYFLAQVARHKLMNAARQPDRNLRVLTAHANMLDGLMADLAEAENEQEDWFNQAVSYANAGNAVTTFNNDNIRDTHGNPTSDFDFDSEDDDDVYDDFDDDDDDDYDECGSDCSCSSGSGSDSGEDIVFMLDAHNRAVQRKRSISTLYNELNSTLSDAEPEEETDYNHYTRDNIQQPPELLHDLDEEPDDDSQPSSPRRNSFDYFAASSPTIEETLTSSEVEKGAEIAQSDDNGEDVPLLGYCFSRSSVLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLI4</accession>
    <name>D4DLI4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017938.1">
        <property type="nucleotide sequence ID" value="XM_003017892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLI4"/>
    <dbReference type="GeneID" id="9579814"/>
    <dbReference type="KEGG" id="tve:TRV_08058"/>
    <dbReference type="HOGENOM" id="CLU_034204_0_0_1"/>
    <dbReference type="OrthoDB" id="4174104at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="645" mass="68783" checksum="1C97E90F0DDB49ED" modified="2010-05-18" version="1">MKRYIGLGVGSNYTYHIPPNLLQISVGSVTSPGQVLLSVVSQPRRLTYIPPGPLFHLACIIQSPLPLLPPSQIGIIHFTRHIRQAEGNLTRQVRLPAANMMSGQGSHFTQANTGKKKKKTKGKHRLAPAASKPAAIDESKPQVASAIADARASSDEKESVEKPRPLSFSKDPVNVSGASANLTQGAHGPPSPTWSAEDSKLGVHNDHNAASRAAANAALFGKRTSYVEEAQSQRPLSSTRATETPRRDSSTLGAAHRTEMPIIGAFPADGEAETADRGPDASSGNEAVEKEEGYNAENKWEDNVADTVVEVDSDSKQQVASGIKEKNEWVKEETEEGPGHTAHITRRHSEVTEYVPPTAAGGVPGKHIERIIENDTVEKEIIEKPVDTAASEAPAQEKVPEPAAPKPSYAAVAAKVSEQPPAPVAPVVPEAPVQTQASAVPAEPAASKETTPAPAPAAAPVPVPAPIPVPLMKQEEHDTAEKANQTELAGEEEAPPATTAHEVPTAEELGVAAPAVPAKAPDRLITTDPVIPGKVPALASSDEQVKAAVESSSTVKPPATKESVQKRDEAQISRLTSQQRREVEKEEKAREKQKAKEQKARDKEFRKSQKHLRKGAKSELPPGNGGAKRLRLRDRIMNRIARLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLN9</accession>
    <name>D4DLN9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000516">
        <property type="protein sequence ID" value="EFE37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017880.1">
        <property type="nucleotide sequence ID" value="XM_003017834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLN9"/>
    <dbReference type="GeneID" id="9583774"/>
    <dbReference type="KEGG" id="tve:TRV_08113"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="394" mass="42258" checksum="322BB60F59162987" modified="2010-05-18" version="1" fragment="single">VFQGIGGGGLSTVVSIIMSDIVPLRDRGVWQGVINIVWSAGSGLGAPLADTIGWRWAFLAQGPCCLLAFVVVGLTLKMPATDQSNWKEKLKRVDFIGAFVLVVAVFGLILGLDRGGNVSWTMPLTIISLSVSAVAFILFMVVEGRFAVAPFAPLHITFGRDLVACYLTNFFSFGGWLAAIFYIPLFFQASDGSSAASAGIKLLPSILLGVSGSLFGGWLMKRTGKYYWITFYSYGLLVVGLVVITLFSGIIANSTPMIIIGMTMCAFGNGIGVTTTLIALIANASPEDQAVATACSYLFRSLGSVISISLSASIVQQFLRSSLRSALKGNKNIDEIVDGVRQSLDYIKHLDPQLREVVRACYGRSTTTAFGFMTILVFLSFISAVFIREQKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ63</accession>
    <name>D4CZ63_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial exoribonuclease Cyt-4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025729.1">
        <property type="nucleotide sequence ID" value="XM_003025683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ63"/>
    <dbReference type="GeneID" id="9581972"/>
    <dbReference type="KEGG" id="tve:TRV_00100"/>
    <dbReference type="HOGENOM" id="CLU_002512_0_1_1"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="471"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="978" mass="110021" checksum="02FC5A4687EA8313" modified="2010-05-18" version="1">MDDRMRELIEQDMKRTDDIRTYLRKWIEKQPKTLDPIMEFNGTAVTPSTQKVGGMFLDNSVLSDSLPELLGSSDLEGDPLPFLRPGDLVQLRHQNGTSSGQLAVYLRTVNDQQQFYTTRGKWRIARPSEVNYITKHRFSPELLEPIFPYLPTTVIAKGNMPQLAMEGGVPRHIGATLLNSILEFEGAASKTFAENATILNSVHDRLAKDTEPVTLTLEQIASQLLGRDPNTLSKADRYAIHQAIDQNPVSIIANQSLSVVESYTFRPKAQTELINRVIKWMREYQTLRSSGMGKKEKRSSNRNPIGQFVKTARQWIYRSRASRKPTQAYSLSPRIDSVDDLQHQAEQLKESSKPSTPSFSETDRDIIEFLRLWILPPLFVRDSSLRSTGSFILFHIGLYDNFNLNEATGYLALQELGILTPWENIHVLNEQVALPGHGLSPVSDAIVEECNRFCEMPSCIDTLVDSMKDFRKDWGETPVFCVDSASAAEIDDGFSLERIPGSSDRYWVHIHVANPSAFIPHDHLLAKGASHFKRSFYTPERVYPMFPPNLTSEKFSLGPGKPTITFSAVVNMEGEILDTKITHGYINNVVYITPDRLRKLFGIDINENPSMSLEVGGTPKGPERPELQEHISEEHKAILETMERLLAGRREKRMKKGAIEFFPNYPSSPLVSGGEEGVRSYTGDISGRYDYNDDPTIGVSGQFTQSDGSLEATKTDFVAHAMLLGGEIAAQWCKERNIPVIFSAAAYNLDKVTTEDQGEFVPGSSPYSQLPRAFSSSKPTPHITLGMDQYSKCTSPLRRYSDLIVHWQVEAALRHEARQSMADQSERYPNQVDETVLPFSREDIKAIIVRSNWQNKAADRAQVLSREFWVLQALFRAHYFGEANLPEGFQCVIVSQLPASSNSASEPDETRYTANLLPFRVRCVVTTDKSCPEFRPGDLVEATISNVNLYTVLLGLRAVRLVHRPEKSRATVPLGFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZB1</accession>
    <name>D4CZB1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000008">
        <property type="protein sequence ID" value="EFE45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025673.1">
        <property type="nucleotide sequence ID" value="XM_003025627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZB1"/>
    <dbReference type="GeneID" id="9581913"/>
    <dbReference type="KEGG" id="tve:TRV_00152"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_2_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="305"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="629" mass="72072" checksum="3EEF9448542D2E45" modified="2010-05-18" version="1">MPVSHSFHRRLLFLTSGAFVLLFIYYFGTVYRHRLGVVPKHGSTVHEEPEEIEEICMGNDPIKALSDKADNAWRKYDSSRSMTFSDAVVEYRVRYGRHPPPGFKEWYIFARENDVRNVDDFDQINDDLRPFWSAEPKTIRRRVAAACQDHSGNSIAAIHIRDGAIANITGDGWRIDTLKSLVARFAQKLPDMDIAMNTLDQPRLVTKWEDMQAMLNKEIASRVTPPDATYSFTKNMEGFFSLTSKNNVTEEDKVKWAGIPSKQYMEIAATACPPESPARNPILSIQEADSRYKIPGAGLVSNFNTSSDLCVVGPAIKNLHGFLFSSSSISHSDALIPIFSECKVNINNDILFPANMYWKDDERYTYNGAEDIDWKMKNETLFWRGATSGGIQTADNWSRMHRQRLEFKMNGTKLIGKTERVLPCNDQSLSSGDSASSNFQPTDFANKHFDFGFTDPMACVPANCEFYNDTYTYKEKIPLSHQFVNKYLVDIDGHSFSGRWRAFLLSKSLGIKATIFREWHDSRLFAWRHFVPLDNRYDDFYALMTYFIGTGTNNTTSSNPHVARHDKTAQNLARQGREWAEKVLRNEDIEAYMYRLLLEYGRVIDDNRDSIGYHGDGSELKEFDEHLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZD1</accession>
    <name>D4CZD1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_00173</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025650.1">
        <property type="nucleotide sequence ID" value="XM_003025604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZD1"/>
    <dbReference type="GeneID" id="9581889"/>
    <dbReference type="KEGG" id="tve:TRV_00173"/>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="255"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="396" mass="43787" checksum="4B002F1DE9A077AE" modified="2010-05-18" version="1">MAARPLARAVARHLSQSASAVSRRSFVAAASSRPTLVAAGRAAIASPATQQIRGVKTIDFAGTKETVYEREDWPREKLLEYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKDGASWKEAIQDGWIPGKNLFDVTEAIKKGTIVMNLLSDAAQSETWPTIKPLLTKGKQTLYFSHGFSPVFKDLTKVDVPKDIDVILVAPKGSGRTVRSLFREGRGINSSVAVFQDVTGKAEEKAVALGVAVGSGYLYKTTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMYAACSTTARRGAIDWSSKFKDTLKPVFNELYDSVKDGKETKRSLDYNSQKDYREKYEKEMQEIRDLEIWRAGKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZK1</accession>
    <name>D4CZK1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025603.1">
        <property type="nucleotide sequence ID" value="XM_003025557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZK1"/>
    <dbReference type="GeneID" id="9581841"/>
    <dbReference type="KEGG" id="tve:TRV_00243"/>
    <dbReference type="HOGENOM" id="CLU_139326_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="17880" checksum="356878F40C78C1E4" modified="2010-05-18" version="1">MQQANAPGDGREEGARQGAPPVFPILSSQSSAGRFDVCSRETQDEDGHPAASHTGERAADGTPDRELRLPVQQCTNVSKCASVRALYSCTSQALVEFERDETRPRKRKEKKRRKKKIGPGRDERESQSQRRPRESHRMGLGDPPSARRAPRSQLDSNGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZK4</accession>
    <name>D4CZK4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025606.1">
        <property type="nucleotide sequence ID" value="XM_003025560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZK4"/>
    <dbReference type="GeneID" id="9581844"/>
    <dbReference type="KEGG" id="tve:TRV_00246"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="156"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="719" mass="79405" checksum="7304FA5A09582F71" modified="2010-05-18" version="1">MDRGSQRVQMADEVQAGASPAQSDLSKEEEAAPKPGGIKWTRYLGLKGKDSQALEERWAHREKWSMGILSDKHTDEVPGTILLLAAKRNEPLGLRNTPARTSATSLPSPYPPSRGSSRGPAPPKKRTADGAIVLDPQPEESMNDPLNWPVWRRDLAMLCLGFYCMLGGGMTPILAAAYNEVSAEYSISFHKVALTTGLYMLGLGLGSVVMSPTAILYGKRPVYIAGATMFIISAVWCAVSPSYVSLVIARIFQGLAVSPVECLPSATIAEIYFLHERAYRVGVYTLLLLGGKNLIPLVSAAITNSLGWRWIFWMVAITTGFSAILVFLFVPETFWDRTPRPRAKRPHMRRSMSDIVHTLRGRSSQPVTPGAVTPSALTPGIEEVDRQLGAITPRKHKNAHVGFAEDEKAEIEKDTPEVMAEKDIAQSPIPAIVVDPEAQRSIPASRDQADPTIQLSQQQIYTSNLRAKPQVSFIQSLKPWNGRIAKDNWFRVMARPLILFAYPAVLWSSMVYALSVGWLIVLSESVAEIYAKRDTYNFTPLQVGLVYISPFVAGILGTIVAGRVSDVIVRFMSRRNGGVYEPEFRLVMGLPSTLATTIGLMGFGWSAQEKDNWIVPTVFFGILSFGCTLGSTTSITYCVDSYRQYAGEALVTLNFSKNVLHGFVFSLFFVQWLQADGAKDVFVALGGIHLALMLFTIPLYIYGKRARMWTVRKHLMEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZM1</accession>
    <name>D4CZM1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025501.1">
        <property type="nucleotide sequence ID" value="XM_003025455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZM1"/>
    <dbReference type="GeneID" id="9581801"/>
    <dbReference type="KEGG" id="tve:TRV_00263"/>
    <dbReference type="HOGENOM" id="CLU_1305670_0_0_1"/>
    <dbReference type="OrthoDB" id="4188597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="234" mass="26230" checksum="6C3E18BA644CE092" modified="2010-05-18" version="1">MDRLIENIPGMGFDIWCDDSFLSQTGPPDAPLPPQPHENPHGDLIYWDNRPLEVNGQAWVLMPVPKCDEDLQAFHMDGGSREIIVLCPKMFEHYSDLGDYQIDMTSRPPTFSKGIHIDSFATSLMFVLVHEVSHCDFFLQNLVTSDIPADVDGYGWQEAVRHADNNHLYALKNAGTSGCLTISMMQHADPSRLDNFALFVLGSYDPSDRHSFYRLIVTDNPKPCFCPKTTGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZU0</accession>
    <name>D4CZU0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025464.1">
        <property type="nucleotide sequence ID" value="XM_003025418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZU0"/>
    <dbReference type="GeneID" id="9581700"/>
    <dbReference type="KEGG" id="tve:TRV_00333"/>
    <dbReference type="HOGENOM" id="CLU_024412_0_0_1"/>
    <dbReference type="OrthoDB" id="4174106at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="347" mass="38647" checksum="15264804B5B6BFF4" modified="2010-05-18" version="1">MEYRDRREKRGSSRTERSRSPERRLVQEKDGAQPTPRCASQVNKKLISSILKRIPSCSEGFLLQGTDVPPLKAEECPGFTGVKIRVLEKDPLDAAVELANNTRSGSDTSSNAVTAAGDTPATIPDHGRTCLLNTAIAQLPKDGCGFVEKLKQEKSLYERSTLSKTLNGDIYPVPRKTAVYSPSVVIFGDSQRPTRELKSIEDPASLPLVSVISTPAIVHPNIRAVRTYVVKADRKGVVRRIPSYEQLYHFKSHRRAVKESIRLLLRISASKKHRRIVVSVLGFDEYMHPKEDSANCWAEVFGEPEFQGGWWTDVVFAVLDPPPHPERNYGQGHIYINKLDGLAVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D020</accession>
    <name>D4D020_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein NPL6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025424.1">
        <property type="nucleotide sequence ID" value="XM_003025378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D020"/>
    <dbReference type="GeneID" id="9581660"/>
    <dbReference type="KEGG" id="tve:TRV_00414"/>
    <dbReference type="HOGENOM" id="CLU_022149_0_0_1"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="64501" checksum="DE88A0F64D662B1E" modified="2010-05-18" version="1">MEIESTPQQLEESDTEMTGVASPQKDTREDEADDDAEGEGEGEGEEVAEDEEVDEDERDTPRTPIEGEEGMTPTADNESEGVAQDSPSRPSSTAGRGGSSMLGRPPRRRRIGRPPKNKPADWDADEGTGTPTGTGRTGTPDTPGARSGANTPVKRGRGRGRPYGGGAGGSSGGTGAGGGGVGRWGPKSRGSSAHVSHLPLDKDGNVLEVVDDEVDLPEDPEGETKVDKLGNLLGGREFRVRTFKVLDRGDRQYMLSTEPARCIGFRDSYLFFQKHRLLYKIIIDDEAKRDLIERDIIPHSYKGRAIGIVTARSVFREFGARIIIGGRKVVDDYHAQEARDRGDVEGELAVPEDRLPAPGEKYNKNQYVAWHGASSVYHSGVPSVPMPVSKAVESKKRKIVVTGDNWMVQHAREASRFNSELASLRRENINGVYDIHTNLMMYPKTMQPTHARWEQIEPSEDSSSSSTSTTIFPSVRGIFSRNFRIHDIAYESAPNSSLNLIPGPDGDYYDLGSNGLISLDNEASSNDHDGGSEGINFKMTPEVLAELPEDCRQAYLDAAAREWQWKNKWKGERVDGARANLAMNFSWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0A2</accession>
    <name>D4D0A2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-alanine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025317.1">
        <property type="nucleotide sequence ID" value="XM_003025271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0A2"/>
    <dbReference type="GeneID" id="9582923"/>
    <dbReference type="KEGG" id="tve:TRV_00497"/>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="49421" checksum="ACA0FCBEBD7ECFF2" modified="2010-05-18" version="1">MLTTELSEADVAGLRANKERLQEWIHHSCQWGTGIRWGDHPTETGMARPALSQEDKQVRDWFVETTKSLGCKVTIDSMGNIFAVRPGKRADVPATFVGSHLDTQPTGGRYDGILGVCAGIEMLKVLEEKGIETEGGVGVVNWTNEEGARFPKSMISAGVWAEGISLETAHSLLEVPTVASLPSAASAPESMKSALEKIGYLGSVPCSYKSFPIAAHFELHIEQGPHLVTAGQHVGVVTGVQAYRWYRINVTGRDCHTGSTAFQHRADAMYASARMMVRAREVADKHGCLASVGIVEVKPGSVNTVPGFVSFSLDIRGPEIEDVDVVDAELRKEFDIIAGEEGKGINKPCRAEWQLDFETPATKFHPECIECVTESAKAVVADKPNPETLYRTIRSGAGHDSVFTNKRVPTSMVFVPCKDGVSHHPEEFSSAEDCVNGASVILQAVVRYDRKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0J4</accession>
    <name>D4D0J4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000033">
        <property type="protein sequence ID" value="EFE44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025238.1">
        <property type="nucleotide sequence ID" value="XM_003025192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0J4"/>
    <dbReference type="GeneID" id="9580733"/>
    <dbReference type="KEGG" id="tve:TRV_00589"/>
    <dbReference type="HOGENOM" id="CLU_144894_0_0_1"/>
    <dbReference type="OrthoDB" id="4168609at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="163" mass="17816" checksum="EF4B2079FD980471" modified="2010-05-18" version="1">MFARFIDAFTKPRNPSVILAVGEDHGTIDVLHLHPETGDVERFGISSHSPTFRCDGSRETTREQIGTVTLPAGGCTVTGSFLEDVTAQIRKRWDNSMVSNPSSVESVAQLVQEVLRPATLEVIRERKEGGVAAKETKTHSVYLIYITRPKPGKVVSLEPTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R7</accession>
    <name>D4D0R7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000041">
        <property type="protein sequence ID" value="EFE44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025165.1">
        <property type="nucleotide sequence ID" value="XM_003025119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R7"/>
    <dbReference type="GeneID" id="9580660"/>
    <dbReference type="KEGG" id="tve:TRV_00662"/>
    <dbReference type="HOGENOM" id="CLU_079449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26496" checksum="E0239BA7BDF7CC0D" modified="2010-05-18" version="1">MQYCAAVILLYRPLANFGVEASERSDYSPQFRLICVKHAMDATRYMEDYRANYGNATTLSGISLHIISTVSTTLIADITERRHSDVSREFHCLIVCVRTLLELEQTYLVALQVRKVIEVVIRICNLENHELQVASLLPEGLHIGASYTPTPSAGQTESSQDEDTRDTKQEPDSSLILQRFRGAAPQPPITTDTMPMPEQPYLDMTYNPFPLLDGMQVHPHPSTMPGDIHATYPCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0W6</accession>
    <name>D4D0W6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_00712</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025054.1">
        <property type="nucleotide sequence ID" value="XM_003025008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580611"/>
    <dbReference type="KEGG" id="tve:TRV_00712"/>
    <dbReference type="HOGENOM" id="CLU_004391_1_0_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1234"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1360"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="178"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="474"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="818"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1376" mass="151860" checksum="B158729543246E9B" modified="2010-05-18" version="1" fragment="single">KNDGEDTAWLYEKAAVLKDASSSSARYISLPPIMSRASAGFADFFPTAPSVLQKKRSSKAAAGQDAGSRLKGRSAAADFFAEEHHHHHHDDGGQLLDDEEHAAGGEASSASSSSTAEQTETATPIDPYSAGSAGSTAAAAAANGGAVARVGSSSSTATESSSSAAATTTLNGMSACALTPLTNTDSSPPRKSGSPMLSSSRLADSEQSSISTATSASASASAVEYEKYHHHQDHDHHAKAVVASSRLPPPRGYKLVYDPDLDKRPPASRDKRRKPQYVAFGEGEPASDAAVAAAAEPELGQNLDPVSPVVVSDPRRAIPNYTRGAASKQKTKYRPAPYTLKPWAYDPATSIGPGPPTQIVVTGYDPLTTVAPISALFSSFGEIAEIDNRTDPTTGRFLGVCSITYKDTRSLRGGSPLTAAQSARRAYLECKKEQRIGTRRIRVELDRNSAACNRIVAKLIALQKQEQLAVFEQQNSDAAASKKSDIPPPPPPLPLLPTGPKAETEPSSQSQSQPKDNVPPPTAPKGPSGKSSLHPALQLQPPDGPRAAPKPPSLVEETPILDQIKRDPYIFIAHCYVPVLSTTVPHLERRLKLYDWKSVRCDNTGYYVLFENSRRGELECERCFRGCHMTALFTYVMNMECQQYGNPSYERSPSPERVKAEQREKSEKARLKRETELDVEEEKRLRAENVDPTTEVVAIAIRELRDKLLEDIKTRIAAPALYDFLDPDRHRAKRQKLGIADPQGIKKPAFYLDTGLGESTTDSRNSPAPPGAQSKNVLALPRIRKARDFERNNSAFVDERRRRPTVRRREFRPLYHRLQQLHDEDDSDDEHQTSFTRDTEDQESRPLSRLSSEADNDDDENLRGSLVPSVSGFGDSGLDSAGIKDELDDLDRELLGEPGDYERVSKKRKRLSLELLEMEKRRKTVDELFGVDTSHLGQEPDDDLSALVDSQAQRLGKEKGKKPKKKTKKQLLEEKKALKLAELQAAADQGLIPKVDDLDLAVTPIEGELDIEAKEEEYEEEEEEDGYVKPEVEWGLSTTEPKPTVEDDEGIVLDLDGWQNIVKDTEDLRFLREALESTSLQSEPDTPIITNVTAWAWNQKQIKAINSHGARGPVHSEIKIDGYYVPNPSGSARTDGRKRILESEKSKYLPHRIKVQKAREEREALAKSDPTAAADAARVIAAKTLSKSTLTSSRSNRVNNRRLIADINAQKQALPTQSGEGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENITANDMIIEYVGEKVRQQVADMRERRYLKSGIGSSYLFRIDENTVIDATKHGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIERDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1A3</accession>
    <name>D4D1A3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024932.1">
        <property type="nucleotide sequence ID" value="XM_003024886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1A3"/>
    <dbReference type="GeneID" id="9580423"/>
    <dbReference type="KEGG" id="tve:TRV_00851"/>
    <dbReference type="HOGENOM" id="CLU_130502_2_0_1"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="12311" checksum="0D5FFC84870DEC46" modified="2010-05-18" version="1">MAKAKKTTDTLSSRLALVMKSGKVTMGSKSTLKTLRSGKAKLILIAGNCPPLRKSELEYYAMLAKVPVHHFHGNNWTISMVTLESSSCSEKGFPSHMLFLYTMCWDIAGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1M0</accession>
    <name>D4D1M0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024896.1">
        <property type="nucleotide sequence ID" value="XM_003024850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1M0"/>
    <dbReference type="GeneID" id="9580387"/>
    <dbReference type="KEGG" id="tve:TRV_00971"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="32835" checksum="808BCCC56D755E45" modified="2010-05-18" version="1">MAPPTMTATSAPSTGDATMSLRSAPIDGVAKDEAPEMTKLRATFPKPPVFEDKVKEREYLKGRLALAFRIFAKYGYEEGVAGHITLRDPVDPTTFWVNPFGVPFAHIRASDLIQVDHEGTVIAGGEIRRLNTAAYMIHAAVHAARPDVQCAAHSHSIYGRTFSTLGIELDITTQDSCAFYKDHALYAQFKGIVLGKEEGLNIAKALGGKKAAILQNHGLLTVGRYIEETVFWFYALEKCCYSQLLADAAAKGRGIETVKIPDEDAQYTYKLIGTPFAGYFNGLQLYEVVEREMNGAHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Y1</accession>
    <name>D4D1Y1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024734.1">
        <property type="nucleotide sequence ID" value="XM_003024688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Y1"/>
    <dbReference type="GeneID" id="9580224"/>
    <dbReference type="KEGG" id="tve:TRV_01083"/>
    <dbReference type="HOGENOM" id="CLU_2235945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="105" mass="12020" checksum="AE0361D738B82F27" modified="2010-05-18" version="1">MNQQNDIIESLQERIRHYEQFSADQEEIKASKEKETELMQIIHRQAREIALISSAWYDFQSRLQNGNIVLSRHRGAAGASAHHAEANRTWLGKQRALVVPKAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2W3</accession>
    <name>D4D2W3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024456.1">
        <property type="nucleotide sequence ID" value="XM_003024410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579678"/>
    <dbReference type="KEGG" id="tve:TRV_01419"/>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000825">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="896"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1457"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1559"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1559"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1572"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1637" mass="182352" checksum="2B4751262DEA1B7A" modified="2010-05-18" version="1">MGQGYSLTSLSAGSAGIDVPELADLTYERSLGTARFMKSIRARHRDGLAFVKVIMKPYPSLKLDPYVRAIMRERRLLEGVPNALGYQRILETSTAGYLVRQYIYSSLYDRMRSVMLFYTKESYTLFFDSSLTLRSTRPFLEDIEKKWIAFQLLCALRDCHAQNVFHGDIKTENVLVTSWNWLYLSDFSSSFKPTFLPEDNPADFSFYFDTSGRRTCYLAPERFLEAGEDPGSRSVNWAMDVFSAGCVIAELFLEAPIFTLSQLYKYRKGEYSPQTGRLMEIEDSDIRELILHMIQLNPESRYSTEECINFWRRKAFPEYFYGFLHQYMGLITEPSPGRTRDSSTPLDSKEADERIGRIFVDFDKISYFLGTSPQVLLDGSQTASPSLTQQPFPLQLDLPKVGSQQISKPLSATDDGTLIFLTLVVSSLRNTSKSSARVKACDILLAFAEKLPDEAKLDRILPFVILLLNDRADHVKVSAIRTLTQLLAMVKVVSPVNAYVVPEYIFPRLQHLISTLPSNPTPIVRAAYASCIASLAQSSLKILDMVQALRSDTRLTSLVPSGAERGWEEEISYHNLYDVARVDLLEFFEAHAKALLTDPDVVVRRAFLGSVPGLCVFFGNPKANEVILSHLNTYLNDKDWILKCAFFETVVGVAAYVGSTSLEEFILPLIVQSMADPEEFVVERVLRSLAKMAKLGLFQRSTTWDLLNIAVRFFIHPSIWIREAAVSFVVDSTTFLSATDKYCIVSPLVRPFLKTNTTDISTVQIFDALKKPLPKNLFEMLLVWATNVDKGLFWKSVSQDATFSLSGSNIPKIRQRGLVSSLSNIPRNEEDDQWLSRLRNIGLNQENEFKFLALKEYIWRVAIRRKKNTDNEKVTPFAEIISLSEHDITPQTVLFDRKQGASRNRHPPRKVQPVHGSRRPHTIADALLDASTAIDSPSDDNQRQVRRQVPEGRGSSVPPSLIRPTATRGTRESQSPTVSHLSSSLNGQPGSPSSSISPLSEGPTQNATDSIAGTDGNGSIKSGPPSLRIPGGNIKRRSSAINLLNRQENSKANAATATSSTNVFGKVDVPHQRDLAQLSRTSTPDPQNHGTQMLRPRYRANHTYHGNDPTILRILDNIFAENYPTDLFDFGPVVQLPSQCLPLHGPGGQASDKPWRPQGGLVAMFGEHTGPVNRVVIAPDHAFFVTASDDGTLKVWDTTRLERNLTPRSRQTHRHAPGTKVKCVTFVDNTYTFVSAATDGSVHAVRVNYQNNRDVIRYGKSQLVREYHISPTDGGSGEYAVWIEHFRTDVHSILLMATNRSRIIALDLKSMTEVYTLQNPIRHGTLTTFCLDRKHNWLLVGTSHGILDLWDLRFCVRVKAWGLPGGTSIRRLAIHPTKGRGRWVCVVGGGSNGSEVLVWDIDRVQCREVYRTSGASKEQTAAPSGQKANINPDISWKAYEPWKVDDDVPEGMLGRFATNAHPSSAGIEPAVGSENSSRGDRNAISALAVGIDYLDGTTDGSKCGFLLTAGFDQSIRFWDVVHPDASLVVSSPDLITDGIQMRPRYDTTHPTTALTITSEWIPSAGSAPTRQGTTSNKKSNSTSAGNSMRPPRSTVISLQQQQLLRNHLDAILDIAILQSPYAMTVSVDRAGMVYVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D380</accession>
    <name>D4D380_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000081">
        <property type="protein sequence ID" value="EFE43679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024290.1">
        <property type="nucleotide sequence ID" value="XM_003024244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D380"/>
    <dbReference type="GeneID" id="9579424"/>
    <dbReference type="KEGG" id="tve:TRV_01539"/>
    <dbReference type="HOGENOM" id="CLU_977239_0_0_1"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32320" checksum="F730275FDD478677" modified="2010-05-18" version="1">MLAPRLFLEVEAGQRRDKQALEINSHIKKEENCSSQARPLTFSGKCQPAYYRASSPASHLSFFCSHFVKFLHYPATAEQAAIMSWPLSPSTSTSSPLTSLPSSPSSRIFHIYNSFPVHYKISDPQKRPLYHVDNSYFTPGTPDLSLYRGEDKKGHLAAVCKFVLFSTCSKIGLMPKPQKSYRDRLNNDIFEIGHKRTHSMGVESSKPSKLSACNYKLVDEESGKIMAVIANNGLKSMNKKGKIELFDTAEYVFAGEQLDIMILMTGIALLEKERRRRAQRRYDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3B3</accession>
    <name>D4D3B3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024222.1">
        <property type="nucleotide sequence ID" value="XM_003024176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3B3"/>
    <dbReference type="GeneID" id="9579260"/>
    <dbReference type="KEGG" id="tve:TRV_01572"/>
    <dbReference type="HOGENOM" id="CLU_1469244_0_0_1"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="184" mass="21089" checksum="28E21CD88ED2DD8B" modified="2010-05-18" version="1">MYAGYNFYTSSIDPVLKIQWWQELLFGGICFVMAIMGTVFFRRGFGLISQINAANLNGKTQISIKVRRMLPFMKQRELTLAPSELSISQKVTVSETELTKAGWSESQQRFARQRALDNTPFFKMPVQKTSLAIFRAFSNARRLFTQEHFVYVNIKGQKSTLRLDALGSFSPEFHMLQKAVVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C9</accession>
    <name>D4D3C9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024238.1">
        <property type="nucleotide sequence ID" value="XM_003024192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C9"/>
    <dbReference type="GeneID" id="9579358"/>
    <dbReference type="KEGG" id="tve:TRV_01588"/>
    <dbReference type="HOGENOM" id="CLU_040684_0_1_1"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="296" mass="33326" checksum="AFA5F1E5DC0DC9C3" modified="2010-05-18" version="1">MAYTVRNVGALNTLEWRAYIEKDGVPISPFHDIPLYANEQKTILNMIVEIPRWTNAKQEISKDDFLNPIKQDTKKGKLRFVRNCFPHKGYLWNYGAFPRTWEDPNVVHPETKAKGDNDPLDVCEIGELVGYPGQVKQVKVLGVMALLDEEETDWKIIVIDVNDPLAPKLNDIEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNSKYVSSLSYLIMYAMDVVHECAEAWEKLMSGQSPAGGISLCNSTLENNRADPSKVEAIPCASNLPPAPIDGSIDKWFFISGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3M1</accession>
    <name>D4D3M1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane ammonium transporter (Ato3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024182.1">
        <property type="nucleotide sequence ID" value="XM_003024136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3M1"/>
    <dbReference type="GeneID" id="9579220"/>
    <dbReference type="KEGG" id="tve:TRV_01681"/>
    <dbReference type="HOGENOM" id="CLU_051062_0_1_1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="284" mass="30217" checksum="2F9E68534D6B7802" modified="2010-05-18" version="1">MSSDIEKDTAGRTTTHESSLKGMSVEEREVAEAAARYGYGPLANGNTSVAAFGKFQPSPAPAPAAAAPSKSFANPGPLGLSAFALTTMVLSLINMQARGVTAPHLVVASAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWISYGIIFTPGGFNIIENIKEANGITGVNNVTGFWLMSWWIFTTLCLVCTFKTNIAFVLLFFTLDLAFLFLGVGHLIESAPGKIYIPLIKTGGFFGILAALLAWYCALSGMADPNNSFIKFPLGRLPWMGNQRVKTEREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U6</accession>
    <name>D4D3U6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024089.1">
        <property type="nucleotide sequence ID" value="XM_003024043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3U6"/>
    <dbReference type="GeneID" id="9577077"/>
    <dbReference type="KEGG" id="tve:TRV_01758"/>
    <dbReference type="HOGENOM" id="CLU_012923_4_2_1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="58880" checksum="13C458CD7FF5924A" modified="2010-05-18" version="1">MTHGRPPIQHTWPLNKCLSKIDISDPYTFLAVKRGILQYAWLKPILALVTIILKATGTFQEGYIGLSSGYLWVGIIYNLSVTISLYSLALFWIIMNDDLKPYRPVPKFLSVKLIIFASYWQGFFLSILQFLGAIPSGPEGYSPNNMAAAIQDLLICCEMPIFALMHWYAFSWHDYANASISSARMPVKYAIRDAFGVKDLIEDTKETFRGEKYQYRFFDSETNVIAHEESRSRMARVMDGMRYERGGKAKYWIPKPKEANSRTPLLGPESSSRRTSHASSSRIRDEGQRTYDIEEPTLNEDDEICFENARKLEFGDWNYPVITTNEVYREQVWHSRASMYSSRQGSSEGNQIRRSGNRQSRRQRSAEGQSGSAYSNIKADKGKQPAALTRGTSRMSQLSSSSRQLADLVDDADDTATQGRQKKKKKRESESERERSLELEKYVATNIKAPGTLHTTLAKHRSSNQSKAKPLTILIIIPITTRMITPAASNMTDPGRDQRGTAVSLTMNMMPGTPLVRPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Z4</accession>
    <name>D4D3Z4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024040.1">
        <property type="nucleotide sequence ID" value="XM_003023994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Z4"/>
    <dbReference type="GeneID" id="9582733"/>
    <dbReference type="KEGG" id="tve:TRV_01807"/>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="519" mass="56764" checksum="2E8B05D93E4A7B4B" modified="2010-05-18" version="1">MRGTDSPPTKAPSVYTTSYTPTVEGEQLLNPVERVACQPENPFSKLITDQSIAIVPSFTLESGVTLYNVPVAYTTKGKLSPTGDNALVVCHALSGSADVSDWWGPLLGGPGQAFDVTRFFIICLNSLGSPYGTASAVTYKDGDKSRGLYGPEFPLTTIRDDVNLHKIILDDLGVRQIAAVVGGSMGGMLTLEYAYFGKNYVRCIVPIATSSRHSAWGISWGEAQRQSIYSDPKYEDGYYAFSDPPATGLGAARMSALLTYRSRNSFESRFGRNVPDPSKRQNINGTQRLPTPPNEHWAVHNDGHKSTRPSRPSSGAQTPRPLTELQFTDPQFTGAAVYTAHAPTPASPGSVTSLELSKRPATYFSAQSYLRYQGEKFVKRFDSNCYIAITRKLDTHDVSRHRADETSQTPVKDALAQIQQPVLVLGIESDGLFTFAEQQEIADGIPDSRLKNIDSPEGHDAFLLQFEQVNRYILEFFREVLPDIMAPSETDANPAGDHVGKLTKSSTFGEAEVDDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4N0</accession>
    <name>D4D4N0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023850.1">
        <property type="nucleotide sequence ID" value="XM_003023804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4N0"/>
    <dbReference type="GeneID" id="9582462"/>
    <dbReference type="KEGG" id="tve:TRV_02047"/>
    <dbReference type="HOGENOM" id="CLU_006760_1_0_1"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="279"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="713"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="878" mass="97022" checksum="6D78F576720BA359" modified="2010-05-18" version="1">MGPFSAFLLVYVLGGLTFIPLVLSLLVLYAYLTLPGPPDSESKTENADPGGLERKGDDQYSYLNARTAELAEKFQRAREADVAAGYFAVCREYVPGGVNGKPPERTTPAGEVIATESPSVYQSVYRSIFDRKQAPTLDANRANGRNVRKARNVFYVILRHGHLMLYDDAEQIEVRYVISLAHHNVSIYGGGEPIPEGELWIKRNAICLTRKDEGENIPGPRPPTLPFYLFSENLSEKEDFYFAILNNLDRVPDSIDSPPTPRQFATQDMVTLVQRLHSSEEHLQTRWFNALIGRLFLAMYKTPELEQFIRSKITKKISRVNKPNFITKLELQTIHSGEGAPLITNPRLKDLTVNGDCCIEADINYSGKFRVEIAATARIDLGTRFKPREVDLVLSVMLKKLKGHILVRFKPPPSNRLWISFDTMPTMEMVIEPIVSSRQITYGIILRAIESRIREVVAETLVQPFWDDIPFLDTEEQYFRGGIWEETRKAEPPRAAVDAEATSDKESDKQPEKPPEKEEPADTGTPETQKESNTEEHGTSASVTHTPPQETIYQAFADSLNDKEAPEKPEIQKTDFRPSSLPDIPEKAAHSASKHRSTRSLSFSPATTGSSIFSPSISITQQSEPRDVPSPTADTSNAAPQLSRSLSDHGTDAASTSDSRSNRSNSMLAESTQSSKSANASPSLAPGPFEPRQAMLSIGSAAAAAKKWGLSVLTRNDQGHRPGEVPDHPVGRGRPLPPPGTPLPSPGRFNFGSIAMPKRKPVTPSPVPERSQSVIEPTRSEPKVQLPKRHDSMLDQDTKSQEILVIKAPVGSEPSSPSKESHGPGGKVDESDDVPDAWSNEVLMDFQDSSMSATESISSPSELSVHRPSKRLDHLKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4P1</accession>
    <name>D4D4P1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000106">
        <property type="protein sequence ID" value="EFE43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023794.1">
        <property type="nucleotide sequence ID" value="XM_003023748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4P1"/>
    <dbReference type="GeneID" id="9582375"/>
    <dbReference type="KEGG" id="tve:TRV_02057"/>
    <dbReference type="HOGENOM" id="CLU_2694763_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="74" mass="8045" checksum="9E2B656E778E3668" modified="2010-05-18" version="1" fragment="single">EGKGHSWIDAQGSSNRDLCVLLESQVDGKLQEGETRAEVSLLFLGLGMNKKATTGQFPNKQTTGGIAKKRKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4P6</accession>
    <name>D4D4P6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000106">
        <property type="protein sequence ID" value="EFE43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023799.1">
        <property type="nucleotide sequence ID" value="XM_003023753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4P6"/>
    <dbReference type="GeneID" id="9582371"/>
    <dbReference type="KEGG" id="tve:TRV_02062"/>
    <dbReference type="HOGENOM" id="CLU_1058417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="263" mass="29674" checksum="632A86275488F44A" modified="2010-05-18" version="1">MMKFSLSKLIPRIYIYVQQNPNILPNLEHTNYTCASRKTCLDEPALKCVPPYPLMYIVTVNTNIYRLISSLTTLLRIRIMVVLPDVVQPAGRIDRQEERQARIPNARVISSSSLFFSPGEAASPRERVSQFGINVRSQSPIVSLPLILCLPVCSSTLRIQMQGTRALFLTGSNFSTLQEMIPSQYSVASSEEKIAPSGSSSPFFFLRFLFSACCLGVVMYLLLHLGALLPTPFWQNEDFIFKAMRDVQRIILLLLLHPPPYCI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q0</accession>
    <name>RRP36_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRP36</name>
        <name type="ORF">TRV_02066</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000107">
        <property type="protein sequence ID" value="EFE43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023791.1">
        <property type="nucleotide sequence ID" value="XM_003023745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q0"/>
    <dbReference type="SMR" id="D4D4Q0"/>
    <dbReference type="GeneID" id="9582365"/>
    <dbReference type="KEGG" id="tve:TRV_02066"/>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397664" description="rRNA biogenesis protein RRP36">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="233"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="355" mass="40667" checksum="E9FB258FE52AF934" modified="2010-05-18" version="1">MALSGILSKRVIAHRADENELEDDFSSSEELNTLGSEDDEDEDEDEDEGEGEGDESENEEAPDNASSEDDGDNDIKSSLSQISFGALAKAQQSLGPLKKGAKRKHGSEEEEEEDNKNTKYKKSKSDALNELRERIRRAKEEKASKSEGSRDNELLDKKHKEARSSKHAPAVQSSKYAVSRRRVVVDGENVAQVKSRDPRFDSAVQSYSHNAKSSSYATSHSDLAAAKNYAFLNEYRDAELKELEEKLRRSKKDDEKARLKKMITSMKDRKRAMENRERERQVLAKHRKKERELIKEGKKEKAWFLKKADLKKEALKEKYESMGAKERQKGIERRRKKVASKEKKEMPRSRRMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Q6</accession>
    <name>D4D4Q6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000108">
        <property type="protein sequence ID" value="EFE43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023783.1">
        <property type="nucleotide sequence ID" value="XM_003023737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Q6"/>
    <dbReference type="GeneID" id="9582356"/>
    <dbReference type="KEGG" id="tve:TRV_02072"/>
    <dbReference type="HOGENOM" id="CLU_2098606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="116" mass="13331" checksum="14BA8AA7015D1CF8" modified="2010-05-18" version="1">MAEQNVESRMAELISSMAQGRGDIVIQGKVRPSNSLMFVCIEALMKLSAYAYLDEQKDHHRTLPRIQVATIALLYYLSTQERERERDEVEVEVEEKEEKVEVEMLISSLGKGRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4U2</accession>
    <name>D4D4U2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023722.1">
        <property type="nucleotide sequence ID" value="XM_003023676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4U2"/>
    <dbReference type="GeneID" id="9582290"/>
    <dbReference type="KEGG" id="tve:TRV_02109"/>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039598" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26933" checksum="6A48EF552AF4BECD" modified="2010-05-18" version="1">MHLSTLILLPALAAAQEQVPFAERLQGWFNQAKELLPTPKVPQAVAPVTTPAPPKAAVVKPKTVSQFNPDNWRDILTPQSNPQEWLIFVTGGNKTCFGQCGQANRAWKEAQNQFALDSQSPNLGRLNCEAQGLLCAIWSVSPPMLWHIQVPSTPAIGEEKPLTPIHPFRLNATTVTADDIYKVHSEKLWEKEPELQTMFHPFNGLAAEYRINEAVGYIIYCLGMIPSWAMMVGISFISRTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D558</accession>
    <name>D4D558_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Developmental regulator FlbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023653.1">
        <property type="nucleotide sequence ID" value="XM_003023607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D558"/>
    <dbReference type="GeneID" id="9582199"/>
    <dbReference type="KEGG" id="tve:TRV_02228"/>
    <dbReference type="HOGENOM" id="CLU_013365_0_1_1"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="538"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79415" checksum="9AAA7041C9B8A36F" modified="2010-05-18" version="1">MSRPALDRSNSLHQHLKHRPYIPLEDHIASSSSLNSSSSSNHHHHHNANSCSTNSSNSQVAGSKASSPSAASTSTSNSNPSASTSSPSPSSSSSSSTGKAFFAHTSRSSRRSLAAIAIQKTSSAFSLGRPAAADNHNHNHQHHQHQHQHHHHHQHQQQLQLQLQQTREEEEDPFRDPDSWESDDRPPAAAMAGSQSASKMHQTSSRLLRMTTDERPFTRDFKDLFSTLMVSLKLETHRVRFSKFEHTFTAEEAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKEMARSVCQRFVDARFIESVDGRFTSQFPLKGALYQLTPKGINILHRFCQRNGITARHIMDIIDSPRNTMQLVILERDSVTDAISNDKGTIEVIFRRFAGQDGPNIKSSVSSSDSDSLSDYTNGVVGVKMARERKIGDKLYQNTFTGKAAMEWLMDCCTTIDRRETMEIASLFVRQGMIACFLEDKSYMAHDPSATLFQPTKNAIYGVTDHGQRICGWIARERPPNSSTPSTSSAPTTAVAPRDSNNARLHHIIQDPALRLLFREFLRYSLCEENMSFYLDVSDFTANYRRAEKAGAFSKMDTVRETLASAYVIGLYNAFLAPGSPCELNIDHALRNSLASRMTRAVGDDASMVKSLTDVVQLFEAAQLSVFKLMSSDSVPKFARDPKYAAVLQEHDFDLNPTTSGRSYSPTPLPERSMSRSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D573</accession>
    <name>D4D573_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023611.1">
        <property type="nucleotide sequence ID" value="XM_003023565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D573"/>
    <dbReference type="GeneID" id="9582157"/>
    <dbReference type="KEGG" id="tve:TRV_02243"/>
    <dbReference type="HOGENOM" id="CLU_783446_0_0_1"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="39449" checksum="78A1FFDBCBFE3C9C" modified="2010-05-18" version="1">MPAGELRTGEIVRDAFRRGKQVFVPYIYKLGGSAETKPSSIMEMLALRSLEDYESLQPDGWGIPTLDASSVAGRENCLGGNGLRGEDGALKGGDGDDCGLDFIVVPGMAFDHGRRRLGHGKGYYDRFINRYRSNVGKGQMPYLAAFCLAEQVLQPPEEVPVGEYDNLVDSLVRDIVAFEKDLACPVPLNLPTKLSPGLFLRLRSQLDLDRVVHHEVHELVKALVNRQLQLQLQLQSRPPGVEPSAYPYLPFYAHCQLLVQPYRDRRPLLQELEDEMDRSQQRLRAASLSSAGHGLVFVFVLFSSTVSLSSFTVVVKLLSAVKKVSKTSLVSKERERKQPSGFSLHQTKKKVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Q6</accession>
    <name>D4D5Q6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4336 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023445.1">
        <property type="nucleotide sequence ID" value="XM_003023399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Q6"/>
    <dbReference type="GeneID" id="9583465"/>
    <dbReference type="KEGG" id="tve:TRV_02429"/>
    <dbReference type="HOGENOM" id="CLU_056292_0_1_1"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29778" checksum="B4DE6977378900E7" modified="2010-05-18" version="1">MPKLAPSDPESVMVIRKVCDDIITCSLPFARVGLFKFGGRATIVRLQTGAIAVFSPVALTPSVSEAVTSLNGTVKYLIAPDMEHHLFLADWTKAYPDAVIIAPEGLWEKRQKNPTTSGPKFEHIYTAQNKETLHISDEFAADFDVEYIHAHVNREIVLLHKPTATLIQADLFFNPPGYEQYRKAQEGPLSGLANKLYLSLMSAKGSAMAQRRVIWYLMSAGGREAFKQSIQKIDGWEFDRAIPCHGDTINQGAKHLFRTLFEWFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6C6</accession>
    <name>D4D6C6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023188.1">
        <property type="nucleotide sequence ID" value="XM_003023142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6C6"/>
    <dbReference type="GeneID" id="9583208"/>
    <dbReference type="KEGG" id="tve:TRV_02651"/>
    <dbReference type="HOGENOM" id="CLU_014393_4_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000211">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="316"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="631" mass="68856" checksum="4C480DEB81A6480E" modified="2010-05-18" version="1">MTSIMSVHSIEEDESDHNAAVEPFEGEDEDANGEPGLDLQGDKEQLMHDETVDNFLAPLAVNDARLYQLGCRFSQLYLELARTSDRQFLPTPVTRLPNGQETGRYLAIDVGGSNLRVAFIELLGAAADDLENSSASSSSNGHPASEAVSNMEKSRDTLRKAQRHRVRRTLEKAWPIAEHLKMDKAEDLFLWIGDCMAEVVADSLATDADVQDAPEELEMGITFSFPMMQDSLAEATLMPMGKGFAITSDLNLGKILLAGYDRHTRRPYGSDEPSTKRRRRFPLPKLKIAAITNDTVATLASLAYMVKSLPNSRVAMGLIVGTGCNATIPMKLTDLHESKAKCVSAQQPDATETVVNTEFTLGGAAPPLRELKFTTKWDIQLDEQCARPGFQPFEYMTGGRYIGELVRLVFYDYLTSVLKLSPKSLPANLIQGYALSTSYLSNHIAPTHTDQDLVAKLKSTLPPPESSSWNWDIYTARAFRKTARIVQTRSAGLVAAAVVGLLACQKEIQLRSDGATNPRRSTNIIVPSFNNSTDTITSVYRPASTTPQDPSTPAMDSPPSGWQSGPEELVVAYTGGIIQHYPNFKETCQGFIDRLVIWDGPQESGKSVFLREASDGGIIGAGVLAGMVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6I0</accession>
    <name>D4D6I0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein YmL11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023183.1">
        <property type="nucleotide sequence ID" value="XM_003023137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6I0"/>
    <dbReference type="GeneID" id="9583203"/>
    <dbReference type="KEGG" id="tve:TRV_02705"/>
    <dbReference type="HOGENOM" id="CLU_044515_0_0_1"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37125" checksum="499D24223F7C9AB4" modified="2010-05-18" version="1">MPPRIRLQSLARRTRTPHTLLQHELQSITASLSALTRSRSMASVAPAATATSMSPETLQPLSHRRPEYRKSQLHRQYASILRTMPLIIYFQHNNLQSTEWANIRRELTKALRKVDENNAAMGRSEPAIADAIKLQIIQTSIYEAAMRVVDFYRPDTAAVSGQGPILDKEDPRLTHDLSYSAYRAVLPKRGQHDFSTLLVGPIATLSFPSVSPDHLRAAFSILAPTGKTGLFPPPPRKANPGLYDLTTQAGLQKLMLLGARVEGKVFDADETKWVGSIEGGLGGLRAQLVGMLQGVSSGLARTLESAGNNLYLTLESRRSVLEEEQNGGKKEEQAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6L6</accession>
    <name>D4D6L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH signal transduction protein PalH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023122.1">
        <property type="nucleotide sequence ID" value="XM_003023076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6L6"/>
    <dbReference type="GeneID" id="9583142"/>
    <dbReference type="KEGG" id="tve:TRV_02743"/>
    <dbReference type="HOGENOM" id="CLU_014594_0_0_1"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="87488" checksum="971C4291EE327850" modified="2010-05-18" version="1">MPLNYGWQTQQGKFNGSRHPCSSLTLGKGGTLVFNDTFSVVLSQDAVFEPSCTTVIEPETYDPSTIVDVREHFYASTSPQMYAIATATVLAYVLSIILFITPRTFFIGGRGGGFLGRHGMISGSYGSSSVIGVGGRPWLQKIAALTVAISLTIATADSFAVAKKQYEMGYMDSTALTNEVVNGLELRIIRVISSTFLWLAQVQTLIRLFPRHKEKVVIKWVGFALIVLDTVFSILNNFVHPGTTIVHPGKLRDAVPALNYLFELALSMLYAAWIVFYSLSKHRFAFFHPKMQNICLVALLSLLALSIPVAFFILDVSQPNIAGWGEYIRWVGAAAASVVVWEWVERIEALEREERKDGILGREVFDGDEMLDVTPSEVAGSSRRGGNDGGLRRGPAWGRLGILSHNPFRPRNKQRPRSPHIHERKRRKTEITPSDIEASQVVETAPPPAVASPVSRENTTSATSTLYCVRYHSVGTPLASNSDLTRTGQVERRGSVDLTKQSTLPMGQSDLITPVPSRKIGIGWLNAVNPFKRRRGSPPQEVATAQAEEGMAATATLATGLSEDRESRWKFPPALSMVASHLHRDWIGSSEKRDTEPPILPVTVIPAKSKRERAQTNPREDSTTPNSRFRWGESPGERKGIETPLPVMVIPARSRSAITWSTPGLDEPGRPFFSSPTNSSPNPHALTDQGSPSSMISSPPQGANSRDPEKNATHSDPRHVQHIMFEEDEEDEQDVISDSPRCQDDREQHDHSETTESTSSSHLSQQPPEPPDSRPHTGAATSTTRQHSSSDLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q6</accession>
    <name>D4D6Q6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023093.1">
        <property type="nucleotide sequence ID" value="XM_003023047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q6"/>
    <dbReference type="GeneID" id="9583113"/>
    <dbReference type="KEGG" id="tve:TRV_02783"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="344" mass="38252" checksum="37156C2E0A973A20" modified="2010-05-18" version="1">MTSFDTAVIQKRATSLAFYQRQLFTTPPLASSDEVDLAGKTAIITGSNTGLGFECAQQLLNLGLSKLILAVRNETKGEEAREKLLSGRNADNHSIEVWKLDLLCYGSIVSFVERTKSLERLDFFVNNAGFTRLSFAINEKTGHEEIIQVNYFSLALLTILILPVLRDKNSAQQPARLVNVSSDTASWARFRERGSVPLLPAFDREENFHPQDRYATSKLLAQLFLTQLVKRLPPSIAIINTPNPGLCQTSLTRNFKGSLQGILFDIFRLIFARTAAIGARSITDAVVNHGSESHGQYLEDGVVQPMAPFVYTDKGEEVAELLWEETMTEFSFANVSEILENISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6U8</accession>
    <name>D4D6U8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023004.1">
        <property type="nucleotide sequence ID" value="XM_003022958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6U8"/>
    <dbReference type="GeneID" id="9583024"/>
    <dbReference type="KEGG" id="tve:TRV_02825"/>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="671"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="854" mass="93098" checksum="9B8E631DCBE73173" modified="2010-05-18" version="1">MRILSLKPSDDSNRTIEVELLRSLKPHTTPVVTTAIDPTSSLLATGSADGSIKVWDLRRGYATHTFHGHGGVISAMCFFEIALERLNEKQKPKFKNIQSNDDDQADSMASGVRLASGSEDGKIRIWDLSKRKSAASLDSHVSVVRSLSFSRSENTLLSASRDKTVIIWDATTWDCKRIIPVLESVEAAGFLSDGPFCYIGGENGKLRVWDSSRGSEVTEDQPIGSEQEAIVTIEYSDSLPFLLTVHVDQSLKIHSLEPLSSFAHGGRIEPLPVSRQISGNDDEVIDMACIGRDRSLLALATNSEYIRIVRAKSMNEAEGSGSHFGADVARLEGHEEIIICLDVDWSGNWLVTGAKDNSARLWRVDPVSSSFTCFATFTGHAESIGAIAFPRSAPAEGTPAFEDPLNHPPPFFITGSQDRTIKRWDTSKLNVTGSKPHTPKALYTRKAHEKDINALDVNHSSTLFASASQDRTAKIWSVEDGAVTGVLRGHKRGVWSIRFAPKDTPISTTTPGSISRGIVATGSGDKTIKLWSLSDYSCLLTFEGHSNSVLKVLWLPPPHISQTDEDISSRGAAQTNPLVASAGADGLVKIWSPSTGEVETTLDNHTDRVWALATPYTPSSATQSQGNTTESNYDFSLISGAADSVVTFWKDTTSSTLSAAVTASSERIEQDQQLQNYIHAGAYREAITLALRLNHPGRLLSLFTTAIDTTEDTAERDPDNLTGNADIDAVLKTLDDELLYILLIRLRDWNTNARTARVSQRILYALFRSYPSSTFIELADRKNVLPNDGKSGKSAAMKDILEALAAYTERHYRRIEELVDESYLVEWVLGEMGGGVGSAAPALNGTDGEDIIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D725</accession>
    <name>D4D725_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000149">
        <property type="protein sequence ID" value="EFE42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022967.1">
        <property type="nucleotide sequence ID" value="XM_003022921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D725"/>
    <dbReference type="GeneID" id="9582985"/>
    <dbReference type="KEGG" id="tve:TRV_02904"/>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112953" checksum="F2B5BFE203297FD9" modified="2010-05-18" version="1" fragment="single">DHGKTSLTDSLIATNGIISPKLAGKIRYLDSRPDEQLRGITMESSAISLYFSMLRRSAPEGTPDKREYLINLIDSPGHIDFSSEVSTASRLCDGALVLVDAVEGVCSQTVTVLRHTWVERLKPILVINKIDRLVTELKLTPLEAYSHLSKILEQVNAVIGSFYQGERMEEDLQWREKVEERVKAAAIKEKDRSKASAESGNQIDAETAEFEERDDEDLYFAPEKNNVIFCSATDGWAFTVRQFAGLYEKKLGIKRATLEKVLWGDYYLDPKTKRVLGSKHLKGRRLSPMFVQLVLETVWAVYNATTGGANSTGDPALLEKITKSLSIKIPVHILRSRDSRNILSAVFSSWLPLSTAVLVSVIEYLPSPIDAQALRLPDMIDDSPDASYVDPKVRDAVVNSKAGKEDPILGYVSKMVSIPESELPSKTRRTPGGTMSADEAREIARRKREEFAKLRSEANDGDVSGLANALADSHLEEAKVEEKVDPEHLIGFARLYSGTLSVGDSIYVLPPKFSPMNPRASPEPTKVTVKGLYLLMGRALENLESVSAGVVFGIAGLEGHIMKTGTLCSQIDGAVNLAGVSLSHPPIVRVALEPVNPADLNKMINGLKMLERSDPCAQYEVLPSGEHVILTAGELHLERCLKDLRERFAKCEIQAGESIVPYRETIISAAEMNPPKNPDLPRGTVIATSGSKQLKIKIRVRPLPKSISEFLLKQAETIKRIYGRRRHLSTDATKESDDDTPETDSPHEEDREEGATSSRNTLSAEDFRKELETCFSAVKEDKEVWANALAKILEFGPKKIGANILFDATPSGRYEKLFADGSNNKSARDSALFSDKISYAFQLATSQGPLCREPVQGVAVFIEDVTLEEIGDEEHTRLTGEVIRLVRDAVWQGFLDWSPRIMLAMYSCEIQATKTMKEGTSFFTILSLLPVAESFGFSDEIRKRTSGAASPQLIFTGFEMLDQDPFWVPATEEELEDLGELADKENVAKRYMDSVRSRKGLVVAGKKLVKDAEKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7M1</accession>
    <name>D4D7M1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000160">
        <property type="protein sequence ID" value="EFE42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022770.1">
        <property type="nucleotide sequence ID" value="XM_003022724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7M1"/>
    <dbReference type="GeneID" id="9581460"/>
    <dbReference type="KEGG" id="tve:TRV_03104"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="187" mass="20388" checksum="B7D809CA8300EC48" modified="2010-05-18" version="1">MTSSKAGIGGAFQPIQEKQAQNQPGLEKNLAPTSESTKLEGAHGFVEYVGSGKLEDKKAIVTGGDSGIGRSVAILMAREGADVTMIYLREEQEDAEVTAEAIRKEGRECLLYPGNLTDEPTCRYAVAEHVKKFGRVDILVNNASRQFLCKEFTTINLNAVKDTFESNILQMITLCKYAVPHMEKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7X2</accession>
    <name>D4D7X2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022685.1">
        <property type="nucleotide sequence ID" value="XM_003022639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7X2"/>
    <dbReference type="GeneID" id="9581344"/>
    <dbReference type="KEGG" id="tve:TRV_03206"/>
    <dbReference type="HOGENOM" id="CLU_021433_1_0_1"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="275"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="553" mass="62892" checksum="2C5060A2CDF3F8C4" modified="2010-05-18" version="1">MGRTGRARPSRKRQTTLSFAPVSSLPPTGEPSRVRSQNLHSEKSSPKGENAATTPRTIPEEQSIFVSSDEDPIRPPSSIKPKTRKRTNPDMNKSSSGESDEIVSPTKRRRTTVQVVIPQAPVTRDQVKIKHYSESDSDIIHSSPLRQRRLALKARAKRVRGPDEKDPVPDGFVQKSGKLQQHEIDLEEDLEILRPSTKAERQRQLELLKRRRAGDKSKMTERNEKGSNDNNPDSPDESEDNEDSEDTTSSEDSQMDVDSDVEPALPEDLDQYDADFVLEDDEGELGVPADEIEVPFEFTRHRYKRLKDHFRDVVEWMVHNKINPAFRRDDAVYEMAFRKVKDEVTGLAGSQFVSSVWNKGFIGSLKARPRIVVLPYPITEGHPCDACNRSKHPASYDIRFDGPPYIQETLESIVGDDSSEDQASDTMERENVDCEGNVIPNENTHFYLGRHCKSKASMAHTLIHWRYHLNEWVVGYLERIGILENSGILKREHWSQKKRTKYANEVVDAMVQAGEVDRLWRDFNLNLKTARASTVGYSPFPCFSAFLNTLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z6</accession>
    <name>D4D7Z6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022643.1">
        <property type="nucleotide sequence ID" value="XM_003022597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z6"/>
    <dbReference type="GeneID" id="9581302"/>
    <dbReference type="KEGG" id="tve:TRV_03230"/>
    <dbReference type="HOGENOM" id="CLU_097980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="183" mass="19597" checksum="9DDA77EF09307919" modified="2010-05-18" version="1">MPIFEKQDNFPSHCLACAKTRVPAPPAVAETSWTTHRRYLRSGIINISCIFVLSRKSFNSSSSSRSGGVWSSNGLPPASSLSLFGLFFFSFSVSWSSSLPAGEDRAVLRDDADETNAWLLAASESSPSWSVIDEGVAASADGAEVGDVPFVVLGAARRPVVCIIEPSLRESINVDCTPGRDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D855</accession>
    <name>D4D855_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022633.1">
        <property type="nucleotide sequence ID" value="XM_003022587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D855"/>
    <dbReference type="GeneID" id="9581292"/>
    <dbReference type="KEGG" id="tve:TRV_03290"/>
    <dbReference type="HOGENOM" id="CLU_027499_0_0_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="561" mass="62313" checksum="6894973A586B9C53" modified="2010-05-18" version="1">MDSDPPLPSPPRLNRKIRVAAQSSKTRPPFPYGSSTSSKSLNKLLGSSGTPSSDPPLFSSDDFQSSALENYDTTAREDAEDGLPEGPIGRKRRYRGTWWGQKLGNELQSMQNKRTKRMGFKSKRNVDSGVWLGSTDTTDDGDESAAVFTCGSDDSVFCEEMGVSTGRPASITRCSASRRFPAPETAGIPIESSSKSPVTKGSRSTESTAHAKARQIINTCLDEGDDRVDLSYLDMGTIPPHILPPLAQLTKQPTVLEHGASAQIFSPLEPSLQLYLTRNLLTYVPKEVFDLVSIRFLSLRQNKLKEIPGAIRKLTLLQELNVGGNNLRYLPWELLGLMQEHGVLKNITLYPNRFLRPDQSEVVKWHINTEAGGIIALYPNTRESENGNAPATSSEALEKWKPIHVATSAPEYFDMEGRAVDRQRIIPTNTPSLRDLALKACSRSPYFSRFIEDDEIMAPPGSSLSSSLPSVSNTRYQDPIVRLLSFANEVRQTGEKICSVCGKSYVMDKVRWIEWWDCKPAETRGQEHGRKPGQRFCPLPFMRRGCSWVCTPDLPTAEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D859</accession>
    <name>D4D859_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000168">
        <property type="protein sequence ID" value="EFE41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022582.1">
        <property type="nucleotide sequence ID" value="XM_003022536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D859"/>
    <dbReference type="GeneID" id="9581241"/>
    <dbReference type="KEGG" id="tve:TRV_03294"/>
    <dbReference type="HOGENOM" id="CLU_021864_0_0_1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="792" mass="85537" checksum="692A5CBAFA30EE5A" modified="2010-05-18" version="1">MTAVASPPSVQSAPRLGWYPTGDGGQGSLSSMSADEVSRMLMPRKSVQRSNSSSSLSSNSSTSSTSTVTSQLPIQAQSNGVSVPAQGSSAESSSNATTRKKPSRYTWSSSKADPVSGVTNTRPQTVSVPPSGVSASSAMSALHQTPPMVPLQHIMPPQQNGVRPGSRPPHEPAVVLSLLPINGTFERKQINVPYFPEVLRIGRQTNAKTLPTPANGYFDSKVLSRQHAEVWSDRAGKIWIRDVKSSNGTFVNGQRLSPENRDSEPHELREHDVLELGIDIISEDQKSIVHHKVSAKVEHAGIHGPNMNILDLNFGDIDPTTGGGLLPHHLSQPLSHMRGRAGSASSTASAASVRSGQSLPGNHINLLHQQRQMNYWSSPISIEQVVKKLTCEMKQAKQLNHDLGQTSGFLSTISNPETSNKERASLLNNIAESPVGTKPPARPKLNKTDSMSRFSDPPAPPPQQPLPEKPDAPPRTFSTDSLPKMSLRRNDTEKAKAATDITPAQSSQILSLIEALTTTKKELDLQASKVKQLENMLRREQSARESAEERARKLESQPPSQVLLSNGTHPGPDEQVDVDLGVAEEESKAPDDSTTTESPEKKDFKPIANAESEEVSPPIVPEPSSDELKRRIDTLLAEMEAAKKQMNHYRESAERAEKEAAESRQTLAEMIEKIRQEKAQESATAAASASKGSPRSRGVLEAEVETATAAPPGEESASGSSTTNIDKVIENCRSIDPEEIRELKSAAAAFAKPQRQDSVLLERSAPYASMLGVVLIGVGIMAYLNGWHKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8T3</accession>
    <name>D4D8T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022310.1">
        <property type="nucleotide sequence ID" value="XM_003022264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8T3"/>
    <dbReference type="GeneID" id="9580857"/>
    <dbReference type="KEGG" id="tve:TRV_03521"/>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="42718" checksum="16F0E40FB4BC051A" modified="2010-05-18" version="1">MSDDSSNKPSVLVVGGLGFIGRHLVHHIHKNNLASELRVVDKLLPQLAWLSPEITEACKDRFVQADASLQQSLPRVFDRADGSQYDLVINCGGESRYSHQDDVYRLRSHALSITLGKEAARRGVKAFVECSSAAIYKVDDKPRKETDKLKPLQKLTKWKVTTEEELAKIDGLNLVVLRFPYVYGEYDTGLLTSVICVGRTYKEIGRPLTFLYAKERPLNTVWVVDAARALWTAATWRASKGPLPSNQDPQPFPTTFNIVDHNNTLKGDLADALERNFGIKCEFLGSLMSQFAKMNQEQILDEMNEETLEVWSELLLAKGITTSGPISPFLEKEVLKDADTTVDGSLFEQTTGFTYLKEKLDPDWLSSVIKSYEQMNWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9E3</accession>
    <name>D4D9E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022131.1">
        <property type="nucleotide sequence ID" value="XM_003022085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9E3"/>
    <dbReference type="GeneID" id="9579028"/>
    <dbReference type="KEGG" id="tve:TRV_03734"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="32468" checksum="2080788C30B5342D" modified="2010-05-18" version="1">MPAFSDNIELILSHQRLVRFLAKDGLVYHGDAILPSGVSDLAKTTKARVIKGEIFGNHQVTDQVQEVKKLLCPLARKDIKTIRCLGLNYAEHAKESNMPLPKYPILFFKPVTAASGPTDDIPVHPMAQECEGLDYECELLIIIGKEAHNVPKSKALEYVLGYSVGNDVSHREWQIKRGGSQWGIGKGFDGWAPFGPGIVTSKIIPDPNALQISTKVNGKAVQNSNTKDMIFGVAETVAFLSQGTTLLPGDIIFTGTPQGVGMGRKPQVWLKDGDRVEVSLENVGSCSNKVVHVNGSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S2</accession>
    <name>D4D9S2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022048.1">
        <property type="nucleotide sequence ID" value="XM_003022002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9S2"/>
    <dbReference type="GeneID" id="9578932"/>
    <dbReference type="KEGG" id="tve:TRV_03865"/>
    <dbReference type="HOGENOM" id="CLU_025591_0_0_1"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="75275" checksum="E010BB5F001B371E" modified="2010-05-18" version="1">MLSMSSNFFQANKKKGQAGQQQGQSARPSLEDAEDFRPALRSSLASYLSGNECQYRDGVDTQLIDTRSIDSKWLAFFACLFFFLFFLCQHSQTDSTDRQQRSRLIAGQQRDSRETAEEKDRQSICCSCSCWLLARPDSAIRQKTLQTDSRQRQRLQTADSRQQIQNRRQQAGYRIGYRIQRGRGRGYYWREKTALVDLDAGLRAGMSITSPSASAKKAIHKIDIAQVGLVSSSSSSSYSLLLQWLTVVQVSLNLQDRLGLAKVRYERLHGLRRDSDSDTDSRPQSQQQQQQQQQQQQHLYGQHNGFPSETGSDCSSSDSADARYSTPFTSSPVRSPMLSRELPRSARSRHAATFDIKTMQCMTSGGSSRKRRRCDPAIALAAAERGDSGRRRQTVPKMPRLSFNGGSSASAAPHSSPLLRRQHQRRTYQAMPSFVSETDTIPDPDIDSTDIDPQLSSRRHHLHHHLHEEDEDHHQQQQQPCTPPPRRSRFTHADDDAAASGSGADLLLYLANSPTPATINGKPATTTTATTTTTITTTTASGNDFLPSTPPTQHAAPYQLLSTPTPSQPFNFADFVNVTPSPAQRGWSASNGTSRTPLTTATAAAATTTTNTTNTTASASGGAVSRTPRTPRTTKDVRKRLNFDALAPPSPVRGSTKRHNTSTHAGPASSAAAGLALQLGEELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA52</accession>
    <name>D4DA52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021907.1">
        <property type="nucleotide sequence ID" value="XM_003021861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA52"/>
    <dbReference type="GeneID" id="9578790"/>
    <dbReference type="KEGG" id="tve:TRV_03996"/>
    <dbReference type="HOGENOM" id="CLU_075132_0_0_1"/>
    <dbReference type="OrthoDB" id="2753389at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="201" mass="21770" checksum="B3E4F5D0FC2098DA" modified="2010-05-18" version="1">MPFPSRLKLLFRASRPTYWTTTLIFYLIGLLQAGSYPQSVPEIMLAVAFSAPLCLNGRSVEKADHAFVLQACKVATIGVILLAIPASLQIPQTMTYVLIALGASWAYTTPPIRLKGRPFLDSICAGTLYWSIWASGFCLRDGEGSTSLQGSNPSVWIFFFCAGLQMFTAVLDQKADSAASIRTIATACGERMAAFLTAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAI0</accession>
    <name>D4DAI0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021796.1">
        <property type="nucleotide sequence ID" value="XM_003021750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAI0"/>
    <dbReference type="GeneID" id="9578676"/>
    <dbReference type="KEGG" id="tve:TRV_04127"/>
    <dbReference type="HOGENOM" id="CLU_012261_1_1_1"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="639" mass="70028" checksum="829DF352E6F1106E" modified="2010-05-18" version="1">MTGAHTLPKDFTFFSPTESEPRTPDRPLRDLSHPPRPHHASHRVRRRRMERKPIPFCAPDVPLPSIELSRISPAESASDSQSNSTPAYIFEGCAGYLDVPRRQRTDPKTPPAQIRDLASQSFENGAVDGTTTPVGASITRPSSACSHASDSSFSSTSAASFDSFDSFISFGGSCTSPETEIDDPFLAVSLPDNKQNLDTPSKSVKNTPVIPANLSQNQRWTSEMDQHLWNTYQTHLQDPTITPFKMLPGSLPPLGVSHRVAREARRAWMKTKQQQEQQPPSQSQSQSQSQSQPSQSLPSQPPETTSSASRNTPQWPRSDAVTRRRLKELCKRKYSIAPHYQRLLESRSPSPPPDLLDSYTATAATPVSVPFTRDLGISLVSGTMPSDPPEAASTPNIVSNTVNSMAATAHHDDIPRLGSPFMYHTWGPSNSRRVSQADTTPVKPAVDAHDTVHVTGSRLRSGIAPDLFTPTNNNQRLPEATVPADAKDQTSARVRIRTRTRGLTTNSSSNSHSNNMLNVNSRHRLIQLFTPPSGSGSNETDGLPSHSQTHSPEVEGERIKRLGSPFNLDLPASKRPQPHPRQYHRPRHAPSRSDTFLMHPTLNTQGQPFFSTLSSAADIDVPDTERAPAPVTALHSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAL9</accession>
    <name>D4DAL9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COP9 signalosome complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021709.1">
        <property type="nucleotide sequence ID" value="XM_003021663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAL9"/>
    <dbReference type="GeneID" id="9576792"/>
    <dbReference type="KEGG" id="tve:TRV_04167"/>
    <dbReference type="HOGENOM" id="CLU_022348_1_1_1"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000022">
        <property type="entry name" value="COP9 signalosome complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="226"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="53960" checksum="44A759DEBD0190FC" modified="2010-05-18" version="1">MESSSQAWAGNGASSSAMDIEPAGEHQGRSLTTPHIIVDGRTKFARLYLIGTCSSFLAVEALKMAVAEAKSGMDVNCYETAVEALSQIAPSDSEAVLDTEWINNTTKVVKADTNRLERELKGYKNNLIKESIRMGNEDLGMHYHRIGDLASASHAFSRMRDYCTTTSHIASMLFKNIVVAIDRSDWLALQANVHRLRSLQFKPEDEPKCKAKLFASHGLAQLAASSYHEAAITFLSTDPALGDNYKEVISPNDVAVYGGLCALASMSRTDLAKNVLENKSFRNFLELEPHIRQAISFFCASKFRLCLDILEAYKADYLLDLHLQRHVRTLYRRIRTKAIQQHIIPYSRVTLDGMAKVFAPKEQIRDEQGQLNPNGAFVSELIGLIQSEILDARIDLEKGVIVTSKPPAREQLHEEALDSMREYLENAHLQILRINVLNAKLEVPGAQAYGSRAEAEAMAAQGASLDDQGQRFSRKGLAAKLGSAFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAM6</accession>
    <name>D4DAM6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sn-1,2-diacylglycerol cholinephosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021716.1">
        <property type="nucleotide sequence ID" value="XM_003021670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAM6"/>
    <dbReference type="GeneID" id="9576799"/>
    <dbReference type="KEGG" id="tve:TRV_04174"/>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29240" checksum="8B59F320788C68B0" modified="2010-05-18" version="1">MSTHVLLDLGDLSYPHSLPGLLQWPTEGLIIATAIIIAAGYYGPEIYSRPLADGIGYADLIGNVTFLDIWVFVLLTSFFTAHLPECVYNVVQARRRNGLPVLPIFLEWTSIIISTISAISWVYSPYSFILKDNHLVLFAVTLCFVFGRMTTKIILAHLTRQPFPYWTVLITPLIGDAVLVNLPAIGLPAVGATVELWYLWGYLAFAFAAYMHWALYVIGRITAFLDINCLTIKKRRASLNGTALGDVTNSKMQAAFNKPVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB16</accession>
    <name>D4DB16_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021573.1">
        <property type="nucleotide sequence ID" value="XM_003021527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB16"/>
    <dbReference type="GeneID" id="9578534"/>
    <dbReference type="KEGG" id="tve:TRV_04315"/>
    <dbReference type="HOGENOM" id="CLU_001485_21_1_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="9"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="960"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="994" mass="109200" checksum="AA55CF0F47F5ADFA" modified="2010-05-18" version="1">MAASGGASSIQVTVRVRPFTIREAAQVSKCDDGMVFMGDGSLAGNSAPKLQQKGLRSIVKVVDDKCLVFDPPEDNPLQRFSRSVIPNRAKRGKDQTFMFDRVFDENTSQGDVYEASTKHLLDSVLEGYNATVFAYGATGCGKTHTITGTPQQPGIIFLTMQELFEKIAERSEEKVTELSLSYLEIYNETIRDLLLPGGSKQGLMLREDANQSVSVSGLSTHRPQNVQEVMDMIMRGNEYRTMSPTEANETSSRSHAVLQINVAQKDRNSDLNEPHTMATLSIIDLAGSERASATKNRGERLVEGANINKSLLALGSCINALCDPRKRNHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSHHFDETQNTLRYANRAKNIQTKVTRNVYNVNRHIKDFLVKIDEQMALINELKQQQKDYESVAFAKFKKQNEKKESVLRESFARLRSAYEHASPERREKIDCMVRLKQVSRRMSMLSAWIAAFDNVCAARGQDDTLSNLQAIRKSAQGVLFELEGSRQHYHQKIGKSSWERALDSALEVGIKQLRELETCDHTDIENLKREAQLLKSNAQSEALSAVSEQDKTSEFEIAQRLLEANFETISAIEHIMQLSEDEAIETGRKILGKLLESCCASTSNVVKPNGSSPIRAEAFPPTKAGTPKRRKRVSLVGRPSLSKPLVPPVTITPPANQTPMKGSPRRKKGPGLRKSIYFTPKKAIKPGKRNVRWKDDTADGPLAEFSKTPQKAAPSSPLPSSGSPSSLPVPTVGSSIPLRSGSRESSPIPTPPSLPSMYSKNSRFQAGFLSKKANEGSPGPSPAPPSLARLSLSDTEQPAPLRQISNSSTLNRRSLDHEPDSHPPDSEAEPIKIDKMDAVKIGSAMRRISNAGSGCGGSTNRPRHRSPSVSSNSPPNENAMFTASQARRMVKSEKEQEGKYGVLGPRTFPVTKPGSQRRVTSIDLKIRDVSNSSRDGVRFSTPTITSGGQPRPSLQGSAANACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH8</accession>
    <name>D4DBH8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exosome complex subunit Rrp46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021404.1">
        <property type="nucleotide sequence ID" value="XM_003021358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH8"/>
    <dbReference type="GeneID" id="9578283"/>
    <dbReference type="KEGG" id="tve:TRV_04478"/>
    <dbReference type="HOGENOM" id="CLU_063514_2_2_1"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26571" checksum="AAE99D123E3EFA60" modified="2010-05-18" version="1">MATPTASLTPLRFANGSASYTSPAGEKILASVNGPGEVSRRDVQNPEEATLEVLVKPGVGVSGPGERYVEGILRGLLGRVILMRDKNMARKGVVVTLVVVENRIVDGKVDVRGGSYLSILPSLLHTALLGLLSAGIPMAMTYTSCLIAISPSGDLLANPSTEQIETSTSLHVLAFSSKGNLLLNESQGCFNLKQWDDVHDLAATLCYASSTSHGDEDVAMDGEAGNTLKDFIRGTVEDKVREEFAWKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBN7</accession>
    <name>D4DBN7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021331.1">
        <property type="nucleotide sequence ID" value="XM_003021285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBN7"/>
    <dbReference type="GeneID" id="9578222"/>
    <dbReference type="KEGG" id="tve:TRV_04537"/>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="322"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="450" mass="49950" checksum="1DEF199131A74538" modified="2010-05-18" version="1">MPLYLSFQRVNDGVCDYDICCDGSDEWAHVGGLKCEDRCKEIGKQWKKTEEEKEKSYSAALRKRKELAAQASKTEKEMQDRILALEKEAQDLEGSLVDLEAQLETARARNRGKTASGQRQGKAYELAQLAKARTDTLRTVLEEVHLQRDQVVNLLREAEGILSKFKEEYNPNFNDEGVKRAVRSWEDYVARKGEHGSDSFGDDALLDALKPEHDEPFGNPEQWAEEAEPGLVHKLASFLPAGIANAIEDGLVSFRSALVSNGLLADSSMDDGSDEPQEVRDAKDKVNGAEASLNLKKSEIQDLKRDLKEDFGVDSVFRALKGECVSQDSGEYTYELCWMEQTKQKSRKGRADTTMGRFEKISSIVVDEATPSGQIVQKTKVTLLYTNGQTCWNGPARSTTVILECGENNELTKITEDEKCVYSMFATTPAACESPVAGKDSQGSSGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC18</accession>
    <name>D4DC18_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021238.1">
        <property type="nucleotide sequence ID" value="XM_003021192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC18"/>
    <dbReference type="GeneID" id="9578083"/>
    <dbReference type="KEGG" id="tve:TRV_04670"/>
    <dbReference type="HOGENOM" id="CLU_077988_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="26944" checksum="3621EAA8E7D2FC09" modified="2010-05-18" version="1">MYSFCRKTTLTKHQSRSHQAEAVSPSAQSCESELYSQQAQHPMSMMSQSPQVPQHQLQSQQPQPQEQQLQSQPQHLQSQPRPQQHSPYQQQHSPIIAVPVADYFHHAQAQPTTVHSIPISAEQSILPPQVHYVTTGMIPSQIPRYDIPITTSASVSTPTSMDHLAYNHPVSVSMPQQQRIQAPQPVPIPHQADGGFQVLPVVAGGAGGQYMKEFDQMKHGQQRFFGSAYPEQMNWEFLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC19</accession>
    <name>D4DC19_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrase/ferredoxin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021239.1">
        <property type="nucleotide sequence ID" value="XM_003021193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC19"/>
    <dbReference type="GeneID" id="9578084"/>
    <dbReference type="KEGG" id="tve:TRV_04671"/>
    <dbReference type="HOGENOM" id="CLU_033921_0_0_1"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44817" checksum="043F205AB174E1E1" modified="2010-05-18" version="1">MQSFLKRGLSSLSLSASSSRSNLTTSTDGQINDIPAEADADNELKAETQITFTTASEDVLFPKVRRELDGEDCDRDCASCTIRYPAKFVVDLEDKLYGNVAGWATHVLIATGKTDWVRDVADEKGSVMEAVEKSGVKPVNGTLKLSASNMPVPDEYHMYPEGEQPTTALILPAFTIVENVTPARAPDLIHHFVDKAATTTTPLNQPPLPNSAPVVDTEPIEDAERGSQLSSISGNNAEGAHDVPAASKIPTPLLSRPCPHAAVILLCSQRTRDARCGQSAPLLRREFERHLRPLGLYRDLHDERPGGVGIYFISHVGGHKYSANVMVYRRRDFEWYKKEAQKKGQGDDDDRGDGIDGGIEGAVQGIWLARIRPEDCEGIIKYTVLKGKVVKPDTQLRGGFDRERGLVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC82</accession>
    <name>D4DC82_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000240">
        <property type="protein sequence ID" value="EFE40537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021155.1">
        <property type="nucleotide sequence ID" value="XM_003021109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC82"/>
    <dbReference type="GeneID" id="9578002"/>
    <dbReference type="KEGG" id="tve:TRV_04734"/>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="33781" checksum="8C9EBE8152F1E357" modified="2010-05-18" version="1">MAKDKERTVNPAQAQRKLEKQKALKKGKAEALNRRNEKLARRNPYRIQRQIDDLKAVEEAGKQLKPQQKEILEALERDLRAVNKAREALGDKAPVFGRGDGGPRRDRDRDGDQGHNVLGKRRRDGQREGRNWRQQESSGSETDESVRRIPMPRDTPPPIPRQHHQRRRGGPNNTEEGEGVAAGGERSVHQLPPKPPVPEAKAVYESAPVLRNLQKEAINKFVPTTVRMKQAAVKGEGQLVEPEEMDKLEKAGYVVSGSGPNAGQLTDTSSAKAAASSLEEEEERFNRELKSVQIEEVEDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY2</accession>
    <name>D4DCY2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020912.1">
        <property type="nucleotide sequence ID" value="XM_003020866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY2"/>
    <dbReference type="GeneID" id="9577733"/>
    <dbReference type="KEGG" id="tve:TRV_04988"/>
    <dbReference type="HOGENOM" id="CLU_069054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="27313" checksum="23A86EF9FF817C27" modified="2010-05-18" version="1">MSLCHTSVKPVTSSALRVLLRRQQQCPRGIRLFSSTRPIYSSSKRELQTATAYRPYSLPESVVPPPRNAGTPDTSISHAIPGLNTTPTYPPPKDTVSSKDDGNASISSYSLPENEAQKSQPVSKNGATPSSETKAKPRKSKLRARKAAVSLTPTALSKLRDLVSQPDPKLIRIGVKNRGCSGLSYHLEYVEKPAPFDEVVEQDGVKVLIDSKALFSIIGSEMDWHEDPLSSRFVFNNPNISKYLSLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD02</accession>
    <name>D4DD02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020932.1">
        <property type="nucleotide sequence ID" value="XM_003020886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD02"/>
    <dbReference type="GeneID" id="9577765"/>
    <dbReference type="KEGG" id="tve:TRV_05008"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="50"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="408" mass="45265" checksum="2FA6C0CE9730A6CB" modified="2010-05-18" version="1">MLSRIAGRAVVGRRLLVAGTRQSSTWGAVPQGPPDAILGITEAFKADSFKDKINLGVGAYRDDKGKPYVLPSVKAAESKVVSSSLDKEYAGITGIPAFTASAAKLAYGATSPLIAQDRIAITQTISGTGALRVAAAFLQRFYPHSKTVHIPTPSWANHAAVFKDAGLTVEKYRYYDQNTIGLDFEGLLQDMQSAADKSVFLLHACAHNPTGVDPTQDQWRKIAEVMKQKGHFAFFDMAYQGFASGDIHRDAFALRYFAEQDMPLLLCQSFAKNMGLYGERVGAFSVACASPEEKKRVDSQIKILVRPLYSNPPVHGARIASAIMNDPQLNAQWLVELKAMADRIIEMRALLKENLEKLGSKHDWSHITSQIGMFAYTGLKPDQMEKLAKEVSLFFFFFFYYYFFFFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDT6</accession>
    <name>D4DDT6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE40003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020621.1">
        <property type="nucleotide sequence ID" value="XM_003020575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDT6"/>
    <dbReference type="GeneID" id="9577320"/>
    <dbReference type="KEGG" id="tve:TRV_05298"/>
    <dbReference type="HOGENOM" id="CLU_1950374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15065" checksum="24A9433FC21564FF" modified="2010-05-18" version="1">MKKIDGERRVADARFCIHNGKRERERALKKNLRGAREEEETEPSPSLFFFSFFSFSLFFAPLPFFPFNMTSQERGKMMLRIHQAGKGGSSSIQRDIRDIYVFLLLLFFFFPYILALIGEGVDLGVKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY1</accession>
    <name>D4DDY1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020558.1">
        <property type="nucleotide sequence ID" value="XM_003020512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY1"/>
    <dbReference type="GeneID" id="9577256"/>
    <dbReference type="KEGG" id="tve:TRV_05345"/>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="304" mass="33366" checksum="F44C33EC4E6ACB7A" modified="2010-05-18" version="1">MLCSTFFDSKRNEKTKKRRRNEEDEREKTVDGTGKTQYNAMTITVGVLALQGAFYEHIQQLKVAAEKLRGSSKTFTKEQWEFIEVRTPAELARCDGLIIPGGESTAMALVAARSNLLEPLRDFVKKPTWGTCAGLILLAESANRTKRGGQELIGGLDVRVNRNHFGRQTESFYAPLDLPFLPGDAGPFRAVFIRAPVVEKVLSAKDGIQDGELAIDGTVVAPSRKPESEVAREAMADKVEILGKLPAKADGSDGPGDIVAVKQGNVFGTSFHPELTDDVRIHMWWLCQVSEAAAKLQKAEVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE26</accession>
    <name>D4DE26_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020496.1">
        <property type="nucleotide sequence ID" value="XM_003020450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE26"/>
    <dbReference type="GeneID" id="9584235"/>
    <dbReference type="KEGG" id="tve:TRV_05390"/>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="196"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="383"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="54794" checksum="324D2E79BB166983" modified="2010-05-18" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQNQIHQQRQQRRHEIATLGYERIINDGLLKRIDGLLTALKKHESDSRNPDELVFQALIESAGDPKEDQPPAPPENVHTQETQPKYSQMMGSLVDQVKKELDESKPENRYQAFITGVEGHKTKVLDLQQQLLEKLAQLEKEESKKITSDSIHTGFDSSFVSSSKTKSEPRKTKESTVELLNPGSAGADNMDAVSSGAEADIEDGDGDEEGITVRPLTKQFAKFKIGDYRETYSFITDHPEILTEKRTDELLMEAFNAQISGDETYARQCVHHGLLLQYCRSLGKDGVSLFFKRITTEDHRAGVMFRDDVNDTYNRIKTRAKELAKSSAEGQSEIEQIQLHAVDPSTKLNISIPPADSKDEAHIAAREIFNRFPSDLQKALESESLDEVNKVLGKMKVEEAEDVVEKLGESGILTVEQGIVDATTAEGKQWLEELEAEKKTKAPETGKEEEIGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE52</accession>
    <name>D4DE52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000284">
        <property type="protein sequence ID" value="EFE39868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020486.1">
        <property type="nucleotide sequence ID" value="XM_003020440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE52"/>
    <dbReference type="GeneID" id="9584225"/>
    <dbReference type="KEGG" id="tve:TRV_05417"/>
    <dbReference type="HOGENOM" id="CLU_066712_0_0_1"/>
    <dbReference type="OrthoDB" id="5409271at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="39484" checksum="1A2645753EDFA870" modified="2010-05-18" version="1">MVYAALCHSNRLRFSSAWTCIYIYIYIYIFFCCVFSSSVCYSNQRSTLGLLLFLHLHQISDYRSTAKEEGDKKRERDREKGERRKKMLPPSDSLAHQNLKLAEVLASIQKQTAAAAAPPPPYAATATTATPVPSNNITAPELLGEFEDDEEDDNLSLAPIVIRIDTSISIDGQNNTVTIPSSSSEDSHSDAQSPVSSIQQLQQLQQRRQAKSAQLASAIISALKSAGALDDRETGRQRPMEVDVNAGIRITGNSNMICPGARKRSSSDLVSGQPDRKRRAQSIPLRGNEYFLARSQLVPEYPRFLFFFAPIFFFSLSTEQSDPTMASVYIQVAQKKPLSIRIRFGVMTIDDGFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEB1</accession>
    <name>D4DEB1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020419.1">
        <property type="nucleotide sequence ID" value="XM_003020373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEB1"/>
    <dbReference type="GeneID" id="9584158"/>
    <dbReference type="KEGG" id="tve:TRV_05478"/>
    <dbReference type="HOGENOM" id="CLU_034486_0_0_1"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="154"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42159" checksum="C0953DE62F69B800" modified="2010-05-18" version="1">MSVPIGSPAQLKASHSKVGNDDSDGDGTGRRKPRTNAATGASAAGMRAISAQAVAFYFRTPVKAFFRTRVDYMALAKAIGPQTTTGGWSWKTTTPGLLANAVQTHGWVFIPYQVLPPLIANVGVGAILYTSYLQILGAMHEPTLMGGKRVYPPPSPPVTFFAGFAAGAIQSVVAAPLDAIQARSRTSDMINGQYRSAWHYGWDKLKTLGARGVFSGWTLSFLKDSLGSAVFFSLFETVKAQGYYHFITRYYGSLQAPSIQKLSSPTQPGGIPVIKPHYALEPAFLMLAGITATIFQQAVLHPLSLVQNIYYRNLDHLDKRVRHSRSGREMMEHRANAYMETFKKCQRQVRRIGGLIIFELVRRKYGVPTDAVHIQLDGYDIILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC3</accession>
    <name>D4DEC3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ell binding protein Ebp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000292">
        <property type="protein sequence ID" value="EFE39813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020431.1">
        <property type="nucleotide sequence ID" value="XM_003020385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC3"/>
    <dbReference type="GeneID" id="9584170"/>
    <dbReference type="KEGG" id="tve:TRV_05490"/>
    <dbReference type="HOGENOM" id="CLU_019574_0_0_1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049403">
        <property type="entry name" value="Ebp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21204">
        <property type="entry name" value="Ebp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ell binding protein Ebp1 C-terminal" evidence="2">
        <location>
            <begin position="648"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="919" mass="100801" checksum="2C8DA68D2EC15026" modified="2010-05-18" version="1">MQCVPGEWAGLAHSINASFTTSRSPSILISRPPATERKERKEKEEPAYLKERPFFPPCNSLLSGLDRSYSTYLSDVDRKFKQLSRDVLPAHPYILSVPTEKPYRLGSRFVSNWAVGENTLFSPEEEQLQYMTFLPHQGEDTLLVSVGGWSDDKGNIVPEEDQRPPSRAASMAAPLTTASQHDALAKRKKKITLSDYKKKALETPPPPPTPPLPGAADPSTNGANGTNGNRPGSVDSDKTLRRPQSNSSKPEAKQNHLQHHQHHHPSQAAAPATSSTSSAPDTRTGSRSNDTKQNGQDNPSVPASTGRVDKNTKLPQSKPSLAKDSPPRKKPRLSIQPEEREKEKTPTKKAGRARQMVPELLSPTLPFDNESFSLSLPPLLSPTLPPDIEEELARLPDDGLEKTSRSHSSSISSISNKAIPSKPKPGANSSSVKQSQQSSLAAEKKPASISSSTTLPPKPPTASSKPTTSQPTPRITTTAPREKLIVKLKYGRQNRKRIEALLKISSKRKPTPTQTSAKPKGLPDSIVVSKSSPPNSSPQPSTTTSIGKQSEPSSGYKRPKAMDGDDVKEPALKRPRSSNTLAPPLSDQAPTPSMQTPRSTSATKHPPASSQDQFLTPKKEPKGTAMRRVGSGDSDMKTPSGSATSVKMTQSLSVESHPSSSAQPSERRGWRDEYQRFVNLGRDLKHASQRNSTHKYSTSHDIQDDKLSATIAVEALLCFVLAFIAEQRFQSLSRQVGNSTGWRSIIAYWQSVLNRTTSYPHLHGICLLLGAACHDSIHSLDLERLATTPFPDEHSPAPTPGSDGNTVTSEETKKQRREFAELRTRLPESYKVARRLWLEGSRELSDSVLTQHYPNTWSKRLKNSADRGREQLKLGEYGGDFYLPLGTASTPLEAVRFAWAFLNEWSEREGVKWKGRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH6</accession>
    <name>D4DEH6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020372.1">
        <property type="nucleotide sequence ID" value="XM_003020326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH6"/>
    <dbReference type="GeneID" id="9584111"/>
    <dbReference type="KEGG" id="tve:TRV_05543"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45206" checksum="D560C9DFDA97778C" modified="2010-05-18" version="1">MVKGDSCKYIASLHERYGDVVRVGPRELSYISPSANRTIFAGKSNKDTIYEKNPVIWLLGSTEPVTNLFFAHSHGNVRHRKLITPAFSENAIREQEPILQNFVDGLIKGLSNRSGKAQFPDSEGIVNIAAWYNFAVFDILTRLCFGEEQGCLIRGDYDPWLQALYEGLLMSHFVQAAHRLRPYHIILERCIPSSLTKAHNPQSAEYYPRKLKESRDKQGNVKPVTTHPEFASFFQEGLSNDELEDNVNVLVAAGADSTITTLSSLTYYLTHNPQCYERLKSEIKNAFQAETDITLAATRRLHYLGAAIKETMRIHPPVPVGLHRVTPKKGAVIDGRPVPGGTWVSVANLAASRSPKYWRDPEKFIPERWLEEDSKFSSDNRQAYTPFSIGLRSCIGMTYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEP7</accession>
    <name>D4DEP7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000305">
        <property type="protein sequence ID" value="EFE39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020282.1">
        <property type="nucleotide sequence ID" value="XM_003020236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEP7"/>
    <dbReference type="GeneID" id="9584033"/>
    <dbReference type="KEGG" id="tve:TRV_05636"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="55"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="415" mass="45665" checksum="5CD61F1E1A0BB80D" modified="2010-05-18" version="1">MAEIDCLAVDRWIETKATGAKYDLSSSCAKPMSIQELKELSEDKSESNEGPLPAQLLSRCLGYGEMAGSTALRSTLAGLYSVKTPLPLPVDNVTITAGASPANYLVFQALCKPGDHVIVHYPTYQLLYVVPQTLGAEVSFWQSKEDDKWKLDVEELKTLIKPNTRMIVLNNPQNPTGAIIPRSTLIEIIAVARENSIVVFSDEIFRPLFHSIHPGDKEFPPSALSLGYDDVVVTGSMSKVYSLPGIRVGWIASRNRALIDKCTKLRAYTTLSVSQLDEAVAAYALDGHCLHALLKQNTDLARENLVLLESFIEKHKWACDWVRPVASSVAFVKFSKMGKPVDDLELCHQLLEKKGVLLVPGSQGFGSNSLFAGYVRIGYAIAMEEFKTGLALLKEFMEEDYENVPLAGGKKLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEW3</accession>
    <name>D4DEW3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_05703</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000313">
        <property type="protein sequence ID" value="EFE39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020220.1">
        <property type="nucleotide sequence ID" value="XM_003020174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEW3"/>
    <dbReference type="GeneID" id="9583991"/>
    <dbReference type="KEGG" id="tve:TRV_05703"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="130"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="340"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="528" mass="57755" checksum="F4842BA846A37BDE" modified="2010-05-18" version="1">MAGMLPASSDPEDSRSESSSVAQDERETDGQDERPQKRRRLSDSSGDFPIAPTTPFPVQTLSRIKKKEVKNERQEESASQADPITANDAFAMGLQSVDSSFSSLGLAPWLVSSLKAMEIKRPTAIQKSCIPEIIKGRDCIGGSRTGSGKTVAFAAPILHKWSEDPFGIYAVILTPTRELALQIFEQVKAISAPQSLKPLLITGGSDMRPQAIGLSQRPHIVIATPGRLADHIKSSGEDTIIGLKRVRMVVLDEADRLLTSGPGSMLPDVETCLSALPPSSDRQTLLFTATVTPEVRALKSMPRAKNKPPIFVTEISTENTTIPPTLKQTYLQVPLNHREAFLQVLLSTEGNSSKSTIIFCNRTKTADLLERILRRLSHRVTSLHSLLPQSERVANLSRFRASAARLLVATDVAARGLDIPSVGLVINYDVPRNPDDYIHRVGRTARAGREGEAITLVGQRDVQLVLAIEARVGKQMVAWEEPGVNIESRIVKATVLKEVGSTKREAMGEIDEGRDVLGRRVRKLKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEY0</accession>
    <name>D4DEY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_05721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000314">
        <property type="protein sequence ID" value="EFE39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020216.1">
        <property type="nucleotide sequence ID" value="XM_003020170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEY0"/>
    <dbReference type="GeneID" id="9583985"/>
    <dbReference type="KEGG" id="tve:TRV_05721"/>
    <dbReference type="HOGENOM" id="CLU_027543_1_1_1"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="119"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="44887" checksum="47465F1A20895E7E" modified="2010-05-18" version="1">MQCSWRKLDDEWTCSLYGRVLSLKQDSDSLWYRSFKPSSVESSTLPTPPASNATTQRTTPDDDDTEALIHHYFNLEYNLSDLYEQWATSDPNFKKKAVQFAGIRIMRQDAWETLVSFICSSNNNIARISQMVEKLCINYGPFIGQLGDQKYYDFPEPSALTGTGVESHLRELGFGYRAKYIYQTANIVANQREPGWLNSLRNPEKPAFNEKPATPGSGAKGDESGYREAHEQLLALQGVGPKVADCVCLMGLGWGESVPVDTHVWQIAQRDYKFGKGKHKTLNKATYDAVGDHFRELWGKEAGWAQSVLFTANLRSFSDRLNPKTEIHDQSTETLKVESKVEATQVKEEAEEDGIRVTTRISVKRELSEGEDTGPKDNPSASEPVPKKRRTRASRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF90</accession>
    <name>D4DF90_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020063.1">
        <property type="nucleotide sequence ID" value="XM_003020017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF90"/>
    <dbReference type="GeneID" id="9583827"/>
    <dbReference type="KEGG" id="tve:TRV_05836"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="147" mass="16210" checksum="95E1EA418FC2C1D8" modified="2010-05-18" version="1">MAQEVVLETTMTCKNFSTLAQRGYYNNVIFHRIIPNFMVQTGDPTGTGRGGSSIYGEKFEDEINPSLKHTGAGVLSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRVKSGMRVVQRMGLVKTGAEDRPVDQVKIMRARLVETEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA1</accession>
    <name>D4DFA1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020074.1">
        <property type="nucleotide sequence ID" value="XM_003020028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA1"/>
    <dbReference type="GeneID" id="9583838"/>
    <dbReference type="KEGG" id="tve:TRV_05847"/>
    <dbReference type="HOGENOM" id="CLU_2145240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="13349" checksum="5A2C0BF3EB7C79E8" modified="2010-05-18" version="1">MLELEGNKQAAVSEKVDQQNQRERQLFAGQQSGDAGCQVVIILLPSLLDGMAMLMLTLTLEVSERREWTGPGGGASPALLPNHGELLERPASNVLASITSTHHPAQLQLSPGHALTAILCTSVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFI6</accession>
    <name>D4DFI6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019968.1">
        <property type="nucleotide sequence ID" value="XM_003019922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFI6"/>
    <dbReference type="GeneID" id="9584721"/>
    <dbReference type="KEGG" id="tve:TRV_05936"/>
    <dbReference type="HOGENOM" id="CLU_070882_2_0_1"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20588" checksum="19DFB29D64CD5871" modified="2010-05-18" version="1">MASPAIASADPAPTSSTSDSTDIYQRLSSYSFTEDPEFKLGLAVILGQPGTPATDEQVNRTDELVTKAKCFYFSKKYAIQPPIDHTSYQHWLQPQSRNENRPLPSTSDNNVGNEAARSGSVSVSTVPEESKSEEGQPVYPSSFARIVELITTGQPIPGIQQIPDTVLTGQETASTAQRRRKPWEKDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN7</accession>
    <name>D4DFN7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAA35-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000340">
        <property type="protein sequence ID" value="EFE39318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019942.1">
        <property type="nucleotide sequence ID" value="XM_003019896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN7"/>
    <dbReference type="GeneID" id="9584712"/>
    <dbReference type="KEGG" id="tve:TRV_05988"/>
    <dbReference type="HOGENOM" id="CLU_956390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="237" mass="26769" checksum="379BF5386A3C5D01" modified="2010-05-18" version="1" fragment="single">MYWYLSHLCSTHLVHLDRIRACVITESQKALSKTGEQSRQDIETRIKFRERTLNLLDRLSTELGVTDAFSIALNALYTILSRHGLIDQDCSSSPGYSAAKLRYELRMKPFLPIFLPEVVPFEIYEREATLDGQSDKAVLNRAVRAAAEAKKGLERYLADGPYLTPKDKSSKTTSGLESDWIKNAKNMLRACIATSIAIDTVKKAILDKQSSKPLNISVQVPEVGSQSRWHEWWAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFY1</accession>
    <name>D4DFY1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019886.1">
        <property type="nucleotide sequence ID" value="XM_003019840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFY1"/>
    <dbReference type="GeneID" id="9584637"/>
    <dbReference type="KEGG" id="tve:TRV_06084"/>
    <dbReference type="HOGENOM" id="CLU_2361258_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="96" mass="10870" checksum="18AEE484E41AEB00" modified="2010-05-18" version="1">MPAGKQSKQANVEGRSCSKALLFLARTRLAGLLGPVTRLLTHNTIWTSMKKKKKNKKKNDNNKDDTTSQGIREKVICWLVDSSRQRRRQGMITLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ4</accession>
    <name>D4DFZ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019808.1">
        <property type="nucleotide sequence ID" value="XM_003019762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFZ4"/>
    <dbReference type="GeneID" id="9584559"/>
    <dbReference type="KEGG" id="tve:TRV_06096"/>
    <dbReference type="HOGENOM" id="CLU_973832_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056475" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="31154" checksum="26730D0401DD31AA" modified="2010-05-18" version="1">MGQLKQLAGILALASPAIAAFSVYALHDPDALKASLGVTSECLSALNYTVECDGPSAVRATKNSDNDLAWSMDDLTTLCTDGCSKSLSTWLDAVEQKCEDEEVTINGLVVDPKAFPMKYISGYDLACLRDSWDKKQPDACSGENPPADCDKKGSEEDVDTLYVTNSYDKELYCSECFMLLWRQRIESPVFPQGNLLDHFTKQFSKLEAACSTKLPLITPAPTVVLGAKDTLPPATGYHTDGSTVFRYASPPAPTITTEEPIAKRTAAPRAMKTFYTPVKCPKLANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG11</accession>
    <name>D4DG11_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SNARE complex subunit (Vam7)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019825.1">
        <property type="nucleotide sequence ID" value="XM_003019779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG11"/>
    <dbReference type="GeneID" id="9584576"/>
    <dbReference type="KEGG" id="tve:TRV_06113"/>
    <dbReference type="HOGENOM" id="CLU_033748_2_0_1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40149" checksum="F45D3461D53E52E2" modified="2010-05-18" version="1">MASSPELSIPSTSISDTPKPYTIYNISIRLPLRSQTVEKRYSDFLKLHESLISQVEKPPPAPLPKKSWFSGTTSNAKFREERRKGLEEYIQAINGSEDSRWRNSTAWRSFLNLPPNNASARASNLHSAIAGPGAAGAPITDPTTWLDCHRDVKTHLHDARLHLTRRDQSSTPQKQHECSASAKSSLVRTGTLLGALEEGLKNISGNSAWSGSKLGEGEIRRRKDLLTSARKEKDALEDLLNSMAAKNKLDSAVASIPDKQALLGIDAATGSRKSAVKGGRVLGKETNRTRELDNEGVLQLQKQIIGEQDTGVEEIRKIIARQKELGIAINNELELQLELLNVVDEDAGKLKSKIDIAQKRTKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG45</accession>
    <name>D4DG45_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000346">
        <property type="protein sequence ID" value="EFE39178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019802.1">
        <property type="nucleotide sequence ID" value="XM_003019756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG45"/>
    <dbReference type="GeneID" id="9584553"/>
    <dbReference type="KEGG" id="tve:TRV_06147"/>
    <dbReference type="HOGENOM" id="CLU_050131_0_3_1"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23762" checksum="CF2F63A875BE199A" modified="2010-05-18" version="1">MIVYFQYEKARLERERIVEMSKGVGKPRVGGPFVLKDLNGETFTEENLKGKYSFVYFGFTHCPDICPDELDKMAEIIDEVRARSNGQEVMRPVFITCDPARDSPEVLRGYLNEFHKDIIGLTGTYEQVKDVCRQYRVYFSTPQNIKPGEDYLVDHSIYFYLMDPEGDFVECIGRQDTPQTASKVILDHIGDWKRAGKPLDVTPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG94</accession>
    <name>D4DG94_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019773.1">
        <property type="nucleotide sequence ID" value="XM_003019727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG94"/>
    <dbReference type="GeneID" id="9583684"/>
    <dbReference type="KEGG" id="tve:TRV_06196"/>
    <dbReference type="HOGENOM" id="CLU_050274_0_0_1"/>
    <dbReference type="OrthoDB" id="4173854at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="30167" checksum="AE6E707D3E218E6B" modified="2010-05-18" version="1">MGLFPSLAPLISTVSVTKKTTIMGVPSAEPPPSFQDTSSGSAAGQNIPPTASPTDDSSASRPSGKSKSDSGSPDEPHSGSQGTTSSASQGNSPEGRPENSQGRPQSGTPNGQQGGSQGSAQASRQKTLSQPPGSSMPVDPGPITSEGAGHSHSVPTRTMFNLGGIPITIQETDSITLGNGPSRTTITSNTTPTTFAVDGHTFTVNPSEVIYLDTTFHLGADPMKSPPLVSGTANPTGRGDSEGPRTDSEGHTISPRPTGTRDGSPSSQSLAVRISTGINTTFVLGISTALIFGGFVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGB5</accession>
    <name>D4DGB5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TRV_06219</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000350">
        <property type="protein sequence ID" value="EFE39112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019736.1">
        <property type="nucleotide sequence ID" value="XM_003019690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGB5"/>
    <dbReference type="GeneID" id="9583657"/>
    <dbReference type="KEGG" id="tve:TRV_06219"/>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="22">
        <location>
            <begin position="93"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="23">
        <location>
            <begin position="223"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFE39112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1086" mass="116452" checksum="62EA98FC8BBF7E3A" modified="2010-05-18" version="1">MPRPVLPPASSLLCRRPLLRLTAAAAAASLSPAPPVLALSNYFSSSPRAASSLPLPLPLAPPPSLSSSAPPSPDQAPFTRQSTTAAAMGASKIDGTAIAKAIRERLNGEIKETQKTNPRFKPSLVIYQGTYVRMKLKAAEEASIICTHVQLPVDTPQSDILARITSDNNDPSVHGILVQLPLPDHMSEHAVTSAVAPEKDVDGFGTLSIGELAKRGGKPTFIPCTPQGVMELLYASGVEITGKHAVVLGRSDIVGSPVSYLLKNADATVTTCHSRTKNVEEIIKTADILVAAIGKPEFVKADWLKPGVVVIDVGTNYIPDDTKKSGQRLVGDVDYAAAVEVASQITPVPGGVGPMTVAMLLQNVVKSARFYFDKERSRTINPLSITPKSPVPSDIAISRSQKPKPITQIASEVGIAPHELEPYGHTKAKVSLDALSRLGHRRNGRYILVCGITPTPLGEGKSTTTMGLTQALGAHLNRVVFANVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAALETRMFHEATSPDAGLYKRLVPTKKGKREFQRIMFRRLKKLGITKTDPNELTPEEIKRFARLDIDPETITWRRVLDVNDRHLRTITVGQAATEKGHTRQTGFDISVASECMAILALSNDLADMRERLGRMVVASSRSGEPVTCDDIGAGGALTALMKDAIKPNLMQSLEGTPVFVHAGPFANISIGANSVVADKLALKLAGTEPDEDHDSSTGFVVTEAGFDFTMGGERFFNIKCRSSGLVPDTVVIVATVRALKVHGGGPDITPGAALPEAYRQEDTELLRKGCVNLRKHISNAKRYGVPVVVAINVFETDTAAEHAVIREEAIAAGAEDAVPANHWAMGGKGAVDLAEAVIKASSQPKNFSFLYGLEGSVQERITTIGREMYGASAVEFSELAARKVETYEKQGYGNLPICIAKTQYSLSHDPALKGAPEGFVIPIRDVRLAVGAGYLYALAADIQTIPGLPTAPGYLNVDVDAETDGEPVEERKRGLLQRVFISIEVKNFSKRRWSEKGKEKNVYLDILPEALLFWETIFTVHLGTVLRSLALVYVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGC4</accession>
    <name>D4DGC4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_06227</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000352">
        <property type="protein sequence ID" value="EFE39089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025824.1">
        <property type="nucleotide sequence ID" value="XM_003025778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGC4"/>
    <dbReference type="GeneID" id="9583634"/>
    <dbReference type="KEGG" id="tve:TRV_06227"/>
    <dbReference type="HOGENOM" id="CLU_014931_2_0_1"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000415">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="469"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="569"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="669"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE39089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="822" mass="91819" checksum="5853795DA337804B" modified="2010-05-18" version="1">MARDCTGEKPCKKQRRRREKEEEEEEEEVVKKKKKKKKKKKSQVLPRPKIGDPEVEDEETPQDRLSLSLSFSSLSPVIPLLASPPSLCWLAPVKSRQPFTRIRSIPTCPVGLSLLSFLQLFPPHLHIMAQNIKEQLVGRSSETPLSAHVKAHFMQHARVDSESGELYMTREDFINAIAPKNEDYHKIKREQYGILFNVADRRRTGKINLQDWSMFEDLLAKPDAEYEITFRLFDTEGTGIVKHETLQKLFSSAKGDNTIPFDWNSGWAALYTGSKKTRHDMTYPQFAQMLRGLQGERIRQAFHLFDKDGDGYIEPEDFQRIILETSQHKLSDHLLENLPTLCNISSGSKISYANVRAFQNIIREMDIIDYIIRSAVRKSDDGKITRSDFLNEAARITRFSLFTPMEADILFHFAGLDAPSGRLELGDFAKVIDASWHSASVLGREALAGASKATEKVTGTTSQVLHNILESVHHFALGSIAGAFGAFMVYPIDLVKTRMQNQRSARVGEKMYMNSLDCAKKVVRNEGVLGLYSGVIPQLIGVAPEKAIKLTVNDLVRGFFADKDKGGKIWWPHEVIAGGSAGACQVVFTNPLEIVKIRLQIQGEIAKNVNETAAPRRSAMWIVKNLGLMGLYKGASACLLRDVPFSAIYFPTYSHLKTDFFGESPTKKLGVIQLLTAGAIAGMPAAYLTTPCDVIKTRLQVEARKGETKYTSLRHCAATIMKEEGFKAFFKGGPARILRSSPQFGFTLAAYEVLQKWLPMPGSEHEVVTPTGYVEPQASLQPASGPLPYLRSRNALKLILDLEPNFGRLQPPAGVSLPVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGG3</accession>
    <name>D4DGG3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine biosynthesis trifunctional protein</fullName>
            <ecNumber evidence="10">1.1.1.23</ecNumber>
            <ecNumber evidence="9">3.5.4.19</ecNumber>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TRV_06267</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="10"/>
    <dbReference type="EC" id="3.5.4.19" evidence="9"/>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000355">
        <property type="protein sequence ID" value="EFE39064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019709.1">
        <property type="nucleotide sequence ID" value="XM_003019663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGG3"/>
    <dbReference type="GeneID" id="9583607"/>
    <dbReference type="KEGG" id="tve:TRV_06267"/>
    <dbReference type="HOGENOM" id="CLU_006732_0_0_1"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="24">
        <location>
            <begin position="220"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00017884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EFE39064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="797" mass="85186" checksum="6E7D1233276A1F28" modified="2010-05-18" version="1" fragment="single">MALPFLLSHTPESSSTEGLSLRQISYFGRVLIKPSSVDFALSFVRDSFSLLDVCIDATAFTDVADIVDVLNTGAILAFVTLDQLQTLSREQSVPSSRIVVLVSSASEVLELKKWVAEDAERKEIGVNCASSEALDTVVSELSDDSSVKTIYRSNDGSTSQTALLTSEQEGVVSIIPSAILSAEKEELSPAKFLVAGAVPDSNTGLYATTVTDERGISLGLVWSSDKSVVEAIRTGTGVYQSRKRGLWYKGASSGDTQELVRVGLDCDNDCLVFVVRQKGRGFCHLGTASCFGAYNGLSRLQHTLQTRKESAPPGSYTSRLFNDPKLLEAKIMEEAEELCQASEKEEVASEAADLIYFALTKCISSGVSLEDVERNLDLKSLKVKRRQGDAKPAWSEKLGLASTKGGSGEPAKEDAKPKPPAAEADGKITMKCYFTASTPPKVVREALQRPSQKSNDAVVNLVRPIIQDVQQNEDAAVLKYTHKFEKATSLTSPVLLAPFPEDLMKLSPETKAAIDVSYENIRRFHAAQQDEKPLSVETMPGVVCSRFVRPIEKVGLYIPGGTAVLPSTALMLGVPAMVAGCKNIVFASPPRSDGSISPEIVYIAKKVGADSIVLAGGAQAVAAMAYGTESITKVDKILGPGNQFVTAAKMFVSNDTSAGVGIDMPAGPSEVLVIADKHANPVFVASDLLSQAEHGVDSQVILIAVDLNEAELKAIEDELHSQAMALPRVDIVRGSIAHSVTFVVKNVEEAMTLSNEYAPEHLILQLKNAADVVPLVQNAGSVFIVLVTTLLASTTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGT5</accession>
    <name>D4DGT5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019594.1">
        <property type="nucleotide sequence ID" value="XM_003019548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGT5"/>
    <dbReference type="GeneID" id="9578368"/>
    <dbReference type="KEGG" id="tve:TRV_06390"/>
    <dbReference type="HOGENOM" id="CLU_027210_0_1_1"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59759" checksum="A9FD9E2C2B31A8DE" modified="2010-05-18" version="1">MSGSAVSPSSSPRLPSPPPFTEVQIAPKSPTVNDGKSDGSDEFLGIPHGQDDASARRIRPGTKAANMASGPPLVPLSELDSPFQLQEHLKASYHHFTQPAGSDTVAPITREIARDLAEPPAGVERSLWLYELCRFLTMKANNLVVAFFAEEPPCSAQTCPEMRASEWQYLCAVHDPPKSCCAIDYCCHTLDWATNVLTSPKFFPSRLTLGSDATGGPQASMRHLTNVFRRVYRIFAHAWFQHRGVFWQVEGHDGLYVFFKTVCDVYSLIPDDNYTIPPEAEGDASHTEPSNSQSQGVNRRLTILRKEDSVTATPPNSLEEPGTGLSAATTRRHRHSPSTGVGVTTIAEAAEDDDLNKNTLEGTQPLKEPKVGRNEKIAEDIAEDIAEEITEEPESLTQNEGQNISLEEQSTESSDSSNTGKPAAVLEESAATLPAPAEEVTDSEKEPTEETPGSPGPSEPTVSSMDDGLEENQTEIPAQPIEEKGEEASESQITQGTESKLDEEDTSAKPEVPIDSDTPSTEQPEPAKEANTTEESEEKDPQEPESNTPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHI7</accession>
    <name>D4DHI7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transducer, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019362.1">
        <property type="nucleotide sequence ID" value="XM_003019316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHI7"/>
    <dbReference type="GeneID" id="9577684"/>
    <dbReference type="KEGG" id="tve:TRV_06643"/>
    <dbReference type="HOGENOM" id="CLU_008699_2_0_1"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="594" mass="65309" checksum="C1CCFA1B729E951D" modified="2010-05-18" version="1">MAETPVEAGDGSGPEDYYVEPLATGRARRSTAGRLMNTLLDAEADDELARIFAEEEDDEEFESGDDEEEGGEAAADDMEIDSSSSDEGDEGGAGGAGNDELEGEKELQRQEKAERAKKRTAQQEGFRMPSQRKKKVKIDPTLPTRTSTLPAPRQRKKSERISWLPTADDGPTRASSRRQTMQNRVQTHARLKRSEQKRVQLIATMEETAKRKEKARPKQMTQAERLAEAEKTERLNFGSLTRWEEMEEKRSEERRLKMEALHNRPLEGPVITFWSGIAKWINEKLAMVGVKSFRQAADADSGRKKKGRPSVETSREGQPAANAANRATETSNNATDTAPTQPTDGQQAPGEPSPFLDGIQLYASMQEASTCPDAEIVQTATSTASKPVTTTTETIALPNEEAHENDVTKSDPSPKERGNEDENGQGQAPNKPAEETVPICPEQELNVEEKPEKVKPALERSSRTCIVLDNFDASTGPERSDVGVLYNPKKPVKLPKTQTEFCPITSHPARYRDPTTGLPYSNSLAYREIRQALAYRYAWSGTFGCFVGPIGVGARGVPERFLAPNAAPPQQLFEHGDGDSKPTTASGDKPAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU9</accession>
    <name>D4DHU9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019207.1">
        <property type="nucleotide sequence ID" value="XM_003019161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU9"/>
    <dbReference type="GeneID" id="9577204"/>
    <dbReference type="KEGG" id="tve:TRV_06756"/>
    <dbReference type="HOGENOM" id="CLU_018320_2_0_1"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="10">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="683" mass="76870" checksum="6CD7935A452994D5" modified="2010-05-18" version="1">MNFSADNVRELRHRLEDAAIKCSERCLYHSAKWAAEMLDSLVPIDEDEGTDTEPNSPMDVSPALPTNPFLGPQDPEEAALETKEAYKYILAKSYFDTREYDRCAAVFLPPSMSSIPLAPRAPSTSKSKTPLQSQKGKEPATIFGAKKKSSSSPQNPFPVLSQKSLFLALYAKYLAGEKRKDEETEMVLGPADGGMTVNKELPGLAQGLEGWFADRREKGLEDSGQGWLEYLYGVVLLKAKNEEEAKKWLIRSVHLYPFHWGAWQELNDLLASTDDLKRVVDELPQNIMTLVFHLYSSQELYQATEQTHQILSELEGVFPSSSFLKTQRALLYYHSKDFEEASHLFSELLINSPHRLDCLDHYSNILYVMGARPQLAFIAQLATATDKFRPETCCVVGNYYSLKSEHEKAVMYFRRALTLDRNFLSAWTLMGHEYIEMKNTHAAIESYRRAVDVNRKDYRAWYGLGQAYEVLDMSFYALFYYQRAAALRPYDPKMWQAVGSCYAKMGRLEQGIQALKRALAAGSYSDGGGMGLNSFSSAGGAGGANPKGAGNASRVLDPETLYQIATLHEKLGDVQGARAYMELTLRQEVILLEDDSDYEPEEKDGWGRQNSSATEHYTEIGGTGVTATTSKARLWLARYFFKGNNFARADELANELRHHGVEVEEAQALLRDIKSRRAFLDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI18</accession>
    <name>D4DI18_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019141.1">
        <property type="nucleotide sequence ID" value="XM_003019095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI18"/>
    <dbReference type="GeneID" id="9580088"/>
    <dbReference type="KEGG" id="tve:TRV_06825"/>
    <dbReference type="HOGENOM" id="CLU_018624_0_0_1"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="397"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="833" mass="91103" checksum="E6A20813EAD8955B" modified="2010-05-18" version="1">MPHPTSSSLPTTASEAKRRSRSLSRSRLSWSTRHSSLNPPPPSSSAPFLIPETVHSNLQDAYSKSGLDSTAEHDRKPRLMSTRAATPSTGTSSSTSTSTTTTTTTTTARYPSLASPLPLSYLPRESISATSESTDSSPTTSSSTFDSPIIMETSPSSSPESPTSITPLGPLRKPEGRVVNSPVPEPHLKPPQHQHQQHSSTVGEKESCNLPESSPSRKARNLKNLSLRLPQPGSCRQPPLSTAPITESSARNLSAPPSPMHHHTTTTNASKRKPPNLTIQTPGFNRCSFGSNAVPPTPTLKPLLRHAESSPSLNSILSPTFPDSTNTSSRPSMSSQQRTTNPGKRPLSGSRDESNSQSTHQQHLFTQHELLERLNEEDDNPISRESRKGSERGYPHGPVLIYDSGLYLYLEPNHEEASRFDVVFNVAKEVRNPFKVAARERQDTVMSVWKANVGRHNSEPSTATSDATFMSAFEYPPSATAEEAESDSPSTPKAEDTPCQRPEYIHVPWDHNSEILDDLYTLCEMIDERLSQGKSVLIHCQLGVSRSASLVIAYGLYKNRHLDFNSVYSMVKARSRWVGPNMSLIYQLTDFRSKLQDKSNTSKQPAPEWLDSPAAQEKAPQLPLPSSSPAFKKPSLESQSSSNTGFSFFSHNPFSLSRLTSSSSKSSNASNSNSNGSSSKRCSVLPRPLPLREKYQTFHSYRRSNSTSRPETLFPNRSFFQPPNKSHGDTDVHMADCPAPTTTLPDESTIFSPKTTDQFVIASPFSPGIFSPGAPALPPVASGLGLAGVDSVRKSLEVNQPTSPINRPTVMYDPRSPQQSTEPIIMRNIDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIG8</accession>
    <name>D4DIG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018965.1">
        <property type="nucleotide sequence ID" value="XM_003018919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIG8"/>
    <dbReference type="GeneID" id="9582125"/>
    <dbReference type="KEGG" id="tve:TRV_06976"/>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="650" mass="70545" checksum="6B8FE85D6AE38B2E" modified="2010-05-18" version="1">MLDAFEVITTSGVVLWSKTYAPVGTHIINALIKDVFIEERTGIDRAARKYNKEQYTLRWTEAKGFGLIFVAVYQSLLHLTWIDELLENIKTIFLGLYKEQLKGSRFRVANYPFDKYFEQQLRELDQTTELPAEDKRQLGAESKRDVLTQADTGGPPPPPVPGLLAVQRQAAPATEVLSDSTPFQTPETSRPVTPSSQVITAKAGPGGRISRRARKAANANSNNTSGAEDKAKKSTNGKSGAKKMRKWGPDGIADEEGDEILDYSANDTGAGTMEDLPAPSVDAIDSESFGTKTQKGQFVLKDLGDEIHSILQNADEEKAKANGSSAGVVNSSIGAISSLFRNVVGGKVLTEADLVKPLKAMEDHLLKKNVAREAAVRLCEGVQKELVGKKTASFQSIDSALRAGMESSLRKILTPTTSLDLLREIEVVTSPTNQQQPRRPYVISVVGVNGVGKSTNLSKLCFFLLQNKYKVLIAACDTFRSGAVEQLRVHARNLKELSARENAGHVELYEKGYGKDAANVAKDAVAYAATNDFDVVLIDTAGRRHNDQRLMSSLEKFAKFANPDKILMVGEALVGTDSVMQARNFNQAFGPGRGLDGFIISKCDTVGDMVGTLVSMVHATGIPIVFLGVGQHYGDLRGLSVPWAVGLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIJ8</accession>
    <name>D4DIJ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018995.1">
        <property type="nucleotide sequence ID" value="XM_003018949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIJ8"/>
    <dbReference type="GeneID" id="9582319"/>
    <dbReference type="KEGG" id="tve:TRV_07008"/>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="725" mass="81214" checksum="B18972DF5632A60E" modified="2010-05-18" version="1">MARPDAPGYIAPNNPHAINQITVGDLGSDEILLLATDSGNVAAYRVERIFWCIENRRAEDTDPVQVGNGVECFFSEWVTQSAWALAIHKFARMIAVSSNTTTITIFAFALVDNTEVSHVTREGSSSRAKHPKVHNNDWIHITSISEFLKLRSWSRQRRRSQNIRLSLSGHSANIPNVSFLNCDLDPHGDWLVSTDINNKLLVWRIWERFRPVNYWDFYSADDDQQYDDLFDDRQRGWNVLAVDPRSFRMKKDLLEACGGPPHKYPDKDAPYDLSFLASKVHDATQYYNVFSSSTPLTQRRNQGPPPDELFPLTHSDDSDGGVEDRINRHDTVPGIKTPPVRTETPSDIPLTVGAQGTLQNNNSPLATHNYSNILADAISNTPVLNESDEDSDETYNEDEDEEDEEGAEDEEDEGITPAPGTNTSHATVSDADIDMDHDNSGDNPSDEDSSETSNLDELDELSDTPMNEDIHSGSNTATKANGKAGLLRDERPTSDLFHSFQILHFSESHIRMLPGPFSTGPSVIFRAALSQVVTNPVQFIEATDRFNMALQIPELGVVVAASQKGRVAILGLTEVRNKGKVFRMDRILPLASQERKRLRPLCPLLGIAASPVVPHLIPPESPSDDYEDTSTGMNDVDVQEIRNASLHPIGPKAGLSGKFPSHLPFGGTKKEKWHGIEYSRRYRLFLTYCDHTILHYELYYDWPKELRGPEAQMAYDKNEPFILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU0</accession>
    <name>D4DIU0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018875.1">
        <property type="nucleotide sequence ID" value="XM_003018829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIU0"/>
    <dbReference type="GeneID" id="9580047"/>
    <dbReference type="KEGG" id="tve:TRV_07101"/>
    <dbReference type="HOGENOM" id="CLU_137528_0_0_1"/>
    <dbReference type="OrthoDB" id="3932329at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19598" checksum="946F5BB8F6C84D73" modified="2010-05-18" version="1">MKKLPMEIVEHICLHLHPFSDPGVACTYELSPNIWRDLLFRQQLLPWLWDLDPAILESQPLQHSNGQPSYSKDDFWDWEQLVRKLAQVEAFEPGNSLENAPLRLRNRKRIWRLLDEGRRFDIEDWIWDGKYQKELELFYERCEASGLILARDEDLNVLSGRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIV9</accession>
    <name>D4DIV9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018852.1">
        <property type="nucleotide sequence ID" value="XM_003018806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIV9"/>
    <dbReference type="GeneID" id="9581496"/>
    <dbReference type="KEGG" id="tve:TRV_07120"/>
    <dbReference type="HOGENOM" id="CLU_664275_0_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="192"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="414" mass="45097" checksum="68E115600183E9BB" modified="2010-05-18" version="1">MLSRNGANFWKEGQSAAPGHAVSMADPTDLNLDAPSDLQDIPDLSPVDDLVPPPEGTYPDKASLIASVHAHAKAHGYNVVVKSSSTPTEKKPGRTAKVWLRCDRGGQYRPRNGLTEETRKRKRTSRLMDCPFMLVAAGNPGIWTLTVLNPSHNHGAIVDKPRQTPHHRVKKGQVTAVPYDWPHDATFTPFTTALVVVDMQRDVCSQEGYMAYQGYDVTPAMALIPKIRRLLDAFRAAGFPVYHTREGHRPDLSTLSTRENFRSHNNPTATGIGSTGPLGRFLIRGEPGHDIVPDLYPLEGEPVVDKPGRGAFAHTDFELLLRNKGIKNLVVVGMTTDGAVASTLREGCDKGFDCLLLEDGAVALDHTLHLGACNSVKMEGGLLGATSRIDDLVHAVDNFKNLLVKKMAPQMMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ98</accession>
    <name>D4DJ98_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000428">
        <property type="protein sequence ID" value="EFE38074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018719.1">
        <property type="nucleotide sequence ID" value="XM_003018673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ98"/>
    <dbReference type="GeneID" id="9581038"/>
    <dbReference type="KEGG" id="tve:TRV_07264"/>
    <dbReference type="HOGENOM" id="CLU_028286_3_0_1"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="145"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="37361" checksum="B1372054D9CFB194" modified="2010-05-18" version="1">MLLKVKPDGQLQNMHIDKFPQLSLFLTDIEFPASADQTNGGKVNGNAKDGKGWITVTYKNSSNPHPESGVGNTLRIPLEPVTSNLKKFEVMMHRSPTTAYDMGVEYHSWFSAWLGFKVVFAYIGEHRRLALGNFASPGVNGGWMSTISSMIPVPIPGLVGTKDASKVLTFADMAPYLVVSQTSVDDVSSRLPPGEPMDVTKFRPNIVLAGAQTAFEEDYWAELIIGEGVKVQLRNNCVRCVSVNVDFDTGAPHKGEAGTVLKKLMKDRRVDKGAKYSPVFGRYGFLHREEGASEAVIRVGDAVKVSKVNAERTTLSEFPVYSIRTADIANIPHAEWPGMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJD0</accession>
    <name>D4DJD0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 transcription factor (Ace1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000434">
        <property type="protein sequence ID" value="EFE38045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018690.1">
        <property type="nucleotide sequence ID" value="XM_003018644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJD0"/>
    <dbReference type="GeneID" id="9580843"/>
    <dbReference type="KEGG" id="tve:TRV_07296"/>
    <dbReference type="HOGENOM" id="CLU_008243_0_0_1"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="849" mass="94277" checksum="52DC0927319A3E9C" modified="2010-05-18" version="1">MSSDLSISPRRRPFLNANLPRLSTGHCDGRSPSNSSNTVRHATLRKEATFHVSASPSSPGDPVLHLPTLLRRSPTSPDTLQELSAARENRVAGWLGSIERNSTGPGNKSLSKQSSLEDDKRNLKALRGLSKRLTSANLMEIDSSFRNQVQTGPPGKENLRAELSDSGVGSSVGEGSLHNITRNVASSLLNTNYLADILKREARESVVSSSSTLSSGGKRHIQRHILLPLLKEQRLKNFHSLVRSVPQRIQSSEITCLRDVEKTLLYLAPHHTISRSSYLSFCEFTIQCVHTTVGYLNDHDQRRPADRPYTNGYFLDLVEQIRQYAALIRSSRERRATSSNRDELDYSSGEELVLEGGLASTGRPAELVRKKKGQAISLKTGEPFVEQKPEVPSLKRAPSMENQESVMRSMARRKKDAPPMNINEKCKHCDKVFRRPCDLTKHEKVHTRPWKCLDTKCKYYQLGWPTEKERDRHMNDRHSKSPKKYKCLYPGCTYDTKRQSNCKQHMEKLHGYKYVRSKNNGRASHQLSPQPTPTTTNISTPQAPSVDIPTPISAQAMSPYLSPSEKQSTPFEKTASDRSPSISVQDSVGYTPSPGVYPAPSPSIYSPSEVGQQNTNHDDFMLFPDSTSLNEYNTMHEDFNAFYADLQAADPSDTLPQLDTNLPSASSTPAGNFAAGFQAQSPLDLVGNNADLDFHFDVTENEYTSMNLQLLSPAQSIEAQAMNCLPEPENLCLPLPALDKNSSISPAGHGNVMLYSPASYESDEGFDDGFDCMKMDIGKQTGDFTLFSGFENNNMCSGLGGNESESWNISSMFPPLGTLNDQLNNANWPQQLGSREIDIDSIMEMDDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ7</accession>
    <name>D4DJJ7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fructosyl amino acid oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018605.1">
        <property type="nucleotide sequence ID" value="XM_003018559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ7"/>
    <dbReference type="GeneID" id="9584532"/>
    <dbReference type="KEGG" id="tve:TRV_07365"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="495" mass="54817" checksum="E95F33E4F50358CA" modified="2010-05-18" version="1">MSQLAKDSHIVIIGAGTWGISTALHLVRRGYTNIKVLDKYPVPSPISAGNDVNKFLELDSSPVGDYVSKTIAQATVSGWKNDPVFQPYYHDTGAIIAATSEAAREDISSGGGMTSANGWIPRSTGQEFRETMPQGVLTGDFPGWKGWWKKDGAGWVAARKSMESAAREAARLGVTFISGPAGDARELVYADGKAVRGVRTEDGRVHLGAKTILCAGAAAENLLDMKHQLRPTAWTLAHIKMTPEEAQLYKDLPVLFNVERGFFMEPDEDKHELKICDEHPGYCNWVTEAGKLKSRPFARQQIPLESEQRVRQFLKETMPHLASRPLSFARICWFKLLTTLLGADTPDRKFLISTHPEHRDLVLGVGGSGHGFAHIPSIGSFIVDVIESKLDPRLAKAFRWRPETAVGRDWGALQGRYGPKGSNRVMNFQDISEDEWTTIGLDQEPAQGRKWASQQLGKEETEKNTPSSKKEQKEQENGIIKHQSNPGVQRILQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJL0</accession>
    <name>D4DJL0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF2418 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018618.1">
        <property type="nucleotide sequence ID" value="XM_003018572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJL0"/>
    <dbReference type="GeneID" id="9584547"/>
    <dbReference type="KEGG" id="tve:TRV_07378"/>
    <dbReference type="HOGENOM" id="CLU_044030_1_0_1"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54005" checksum="5C027F315A16D25F" modified="2010-05-18" version="1">MPPLIRRRPLLERIKAYLNPLDFLLWLSEELDSSDWEQWEKEWALPVGIALNVLFLVARANSQKSSRAHDDVFGDEGGVSYVAWLVCGIFDQNGSFLGFHMLTDISVLQASFIVHALALLSISNALYAFCRTRPYRLFEVPIENVPSTPSAKRVQVNSSPMSSTPLRFISDVLSASSAEKRAHPDAHRDVWQLSVWDPHPISIRLFCLFSPGHILVYWLFLPTLSSDPRPSVTIVTTIFLALLLTAQMSALSASYSQQAKDSALVHKEVLNEYDTKFVHPRTDPDVRDVATQFSQADHFIPHKDEKYNVVETYAPSTTQHTFKTRPNPNYIHHVDPDYSVKNRPQVTPRTSLSTPQVTSTGSIQRTTDIQTPSYTMDTFTPINKKSGAIRQPQFRPPSGTGDGGSLGVYSHAQSPLRKSATPYLDRRQSSSYRDSDGAHSPRKPPSSPLKRSSVAGDMSSILSSSRRARLADGLSPRRESGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJL3</accession>
    <name>D4DJL3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018621.1">
        <property type="nucleotide sequence ID" value="XM_003018575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJL3"/>
    <dbReference type="GeneID" id="9580772"/>
    <dbReference type="KEGG" id="tve:TRV_07381"/>
    <dbReference type="HOGENOM" id="CLU_061829_1_0_1"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="236"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="35692" checksum="13F9742C90270E3F" modified="2010-05-18" version="1">MAEGTSISATPADETHETNPPAFHAIRLNDVSGLAGRPTPMPRKLFLKRRSELFNGTGANRLSGGEGEEDDDDDDDDDEDDDVEDIYPNGSSTYGTDEDDFVAVNHSDASDHPWYMRSRVPARNSELAKLHPYVQLLSVSDLDDCEKVELAFPESERCSRENLTYRLSKCPELSLGIFSIPPATADNEKPRPVVIAHLLATRTTSPVITNATMGVPKDWRTKKSTLPSPGEEEPVGHQDQGSTIAIHSLAVLPEHQDKGLGKMLIKSYIQRIQDAKIADRLVLLSHDHLIPFYTGLGFENVGRSKCTFGGGGWNDMVLDLSKAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK19</accession>
    <name>D4DK19_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018440.1">
        <property type="nucleotide sequence ID" value="XM_003018394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK19"/>
    <dbReference type="GeneID" id="9584370"/>
    <dbReference type="KEGG" id="tve:TRV_07540"/>
    <dbReference type="HOGENOM" id="CLU_828937_0_0_1"/>
    <dbReference type="OrthoDB" id="4316405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056564" evidence="2">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="35970" checksum="7988B0A1032CED1C" modified="2010-05-18" version="1">MLSSVVRFSVLPIVLAWLVLLAGPVKADNFLAHGYERLFFWGTYETFCLIEGPDKQQHLLPFKQQKGQESRNNRGSGPGGMLTYPEFIARVEDRPLPPDHPVLSHPDPPGRVGDAVADLLKYKLTGEVSVNALDPSLRGKTFNKPPGGKKKPGSGGGSRNFYDPKDPHRTSFTVLVDGLVGGLLQHLANPRNRGIFQQNLPFMKEALKATITLREETTSIYLLKKLSSPVKDGGFDLDVKLDWKDSKIPLGSRYPEFRIRETFDANGGKLRGLGFKNADDFGDWVRHFGDPNYKGKVEFGPGAFTHHRLLTSWREADRKLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK90</accession>
    <name>D4DK90_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018375.1">
        <property type="nucleotide sequence ID" value="XM_003018329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK90"/>
    <dbReference type="GeneID" id="9584308"/>
    <dbReference type="KEGG" id="tve:TRV_07611"/>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000006">
        <property type="entry name" value="CFIA complex component Rna14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="10">
        <location>
            <begin position="239"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113240" checksum="4126F0621C9562F6" modified="2010-05-18" version="1">MAEEGAEQGYLQSQNLNTDADATAGSDSDDYDPSETIQEQFPANIAASNYNTIPHMSPFASSSTSTPAPGANLPERMPGESYNNNDSTFSLTPSGAEPKGSTTISQIGVFEEGSTGDEDGGDAEYEPPAAALSAQVQNSISTSADMSQRSLSENINEPVSHFHVQQQNIASDQNTPPVSINLPASDSHVAYTVQNDSAPKPMQGESKTPGRSAIQSANSSLPSTPPVAAAASRTRLPHDRVGILEDRIKADPRGDTEAWLELISEHRSRNKLDSARQVYERFFKVFPSAAEQWVEYATMESENNELYKLEQIFTKCLLSIPNVQLWSLYLDYVRRRNNLTTDTSGDARRTITSAYDLALQHIGIDKDSGNIWVDYIQFLRSGPGNIGGSGWQDQQKMDLLRKAYQRAICIPTQSVNTLWKEYDQFEMGLNKLTGRKFIQDKSPSYMTARSSYTELQNITKELVRSSLPHLPPAPGYEGDFSFSKQVEIWKRWIQWEKDDPLVLKEEDLASYKQRVLYVYKQALMALRFVPEVFFDTADFCFQNSMETEGNDFLKQGIEANPESCLLAFKRADRLELSSVSEQDPKKRGTLVREPYDKLLDALYELIAQVRAQEATDIAKLEEQAAQAEPEQPTQLENDDDDDDDETGNPPTQESAKAKEIESVKKDYAAKVGVLSKAISFVWIALMRAMRRIQGKGKPGEIAGSRQIFADARKRGRITSDIYIASALLEYHCYKDPAATKIFERGAKLFPEDEVFALEYLKHLIDINDITNARAVFETTVRRLASNPKNVAKAKPIFAFLHEYESRYGDLVQINNLEARMRELFPEDPSLKQFSHRFSAPSFDPTTFQPILSPSQLKPRTISSLEEPSSRPNSPSIRHPTSNTHSPKRSFPLDEYSDELNRPRKFIRAESPLKGAAGRREQQKRLQSNGSSGGPTAARKQPQQPPPSAGPLPRDVVYLLSIIPPASTYDATRFSPEMMVNLLRQIELPSSVSQLRLSQQTGAGSHQYPQYGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKD2</accession>
    <name>D4DKD2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000466">
        <property type="protein sequence ID" value="EFE37691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018336.1">
        <property type="nucleotide sequence ID" value="XM_003018290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKD2"/>
    <dbReference type="GeneID" id="9580031"/>
    <dbReference type="KEGG" id="tve:TRV_07654"/>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="375" mass="40535" checksum="FBE9D1020C5CF40E" modified="2010-05-18" version="1">MAASNKIVVIGGGVIGLTTAYLLSKDKSNQVTVAAKHMPGDYDIEYCSMWAGANFLPTGAEGSAHARWETNTWPVLEDLAQNHPEAGIHFQKSVVINRKKDANFSTGLWFKELLRPDPWYKDIVPGPAAKFTLTPDSDLPEGVDNQAEFTSVCMNAPVYLAWLVSQCCKNGAVFKRATFKHIFEAAKVHSSGQKPDLIVNCTGLGSLKLGGVEDTKMYPARGQVVVVRNDPGAMYSLSGCDDGDDEACYMMTRAAGGGTILGGSYQVNSWDSQPEPSLAVRIMRRCVAVCPQLVGKDENGKQRGIEGLDIIRHGVGLRPLRQGGTRVEKDQIDGIAVVHNYGHGGFGYQTSFGCCVEVAALVKEVLAEKKIKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK3</accession>
    <name>D4DKK3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018275.1">
        <property type="nucleotide sequence ID" value="XM_003018229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK3"/>
    <dbReference type="GeneID" id="9579971"/>
    <dbReference type="KEGG" id="tve:TRV_07725"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="355" mass="40239" checksum="E3D479DB9126F9B1" modified="2010-05-18" version="1">MELGPARVGQDLKLTRNPHSWNNRASIIFLDQPVNVGFSYGKSGAFNTPSASKDVFAFLTLFFKQFPQYALQDFHIAGESYAGHYIPVIAEDILKQKSNIKFKSVLIGNGMTDPYTQFASYPPMACGKGGYSAVLDQPTCKAMEAAVPQCQKEIKRCYDKPTDVATCVKGAKFCKDALVRPYSRTGQSIYDIRGRCEDPKDLCYPILGWITKYLNQHHVQKAIGAEVSHFKGCNNHISSQFFAHGDYNQPFHRKIPGILKDVNVLVYAGDADYICNWLGVKEWTEALQWPGRHIFRRKNLSVVYHSVNKWPLGRVKYHNGLAFLQVFKAGHRVPYDQPENALDFFNRWLAGEWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKT1</accession>
    <name>D4DKT1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar membrane PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000482">
        <property type="protein sequence ID" value="EFE37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018186.1">
        <property type="nucleotide sequence ID" value="XM_003018140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKT1"/>
    <dbReference type="GeneID" id="9579557"/>
    <dbReference type="KEGG" id="tve:TRV_07805"/>
    <dbReference type="HOGENOM" id="CLU_019699_0_0_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24165" checksum="AC90AAF8A6FBDE43" modified="2010-05-18" version="1">MAVPLTHREAASGILGSISLACWIFLLVPQLIENYKNGSAKAISFAFILVWFIGDVANLIGALWAKLVPVVVAIAIYFCIADGVLICQCIYYNEKVSREMERRISRHTAYEDDGTHVPQPTTPLLSRRMSENLGQSGRRRPDGNSLNHDPLAKMLAEDEPKSTWAKNILSLLGICTAGIAGWVIAWKTGAWQPTPIQPIKGPAEMAVGAQVAGYLSALCYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKY7</accession>
    <name>D4DKY7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF895 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018165.1">
        <property type="nucleotide sequence ID" value="XM_003018119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKY7"/>
    <dbReference type="GeneID" id="9579536"/>
    <dbReference type="KEGG" id="tve:TRV_07861"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF54">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G04110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="487" mass="54523" checksum="3B1C61916FFA48E0" modified="2010-05-18" version="1">MTSVASGPDAAIPVGTYQHNGPRWMYRQLKIGRFYTPWFASPVAQLILVSLVCFLCPGMFNAVSGLGAGGLVNPQDIDKANVALYSTFAVVAFFAGSIANRLGLRYTLTFGGFGYFLYVASILSYNHNKNDGFLIFAGALLGVCAACLWTAQGAIMMSYPDEYSKGKFISWFWAIFNLGGVIGSLVPLANNLHNKSNSVQDSTYILFMVLMFVGFLLGFALVNARDIKRSDGTRVILMKNPSWKSELIGLVTVLKSDWYIIALFPMFFASNWFTTYQFNAVNLAKFNIRTRALNNVLYWISQMIGAFVFGYGLDAPRVRRSIRARYALVSLFLITMAIWGDGWFNQKQYDRADITETNRMDWTDPNYAEPMVLYMLYGFYDAAFQTCAYWFMGALTNNSRKLANFAGFYKGIQSAGAAIAWRIDSLGVSYRAMFISNWVLLASSLIIAAPVIWKKIKDITDIMKDLKFSDEDLEEVSTAAAMELRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL91</accession>
    <name>D4DL91_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">VHS domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000496">
        <property type="protein sequence ID" value="EFE37379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018024.1">
        <property type="nucleotide sequence ID" value="XM_003017978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL91"/>
    <dbReference type="GeneID" id="9579156"/>
    <dbReference type="KEGG" id="tve:TRV_07965"/>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="11">
        <location>
            <begin position="131"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60145" checksum="CA7CDA10FDEF7472" modified="2010-05-18" version="1">MTIVQLINSRNANVAMLALALLDICVKNCGYPFHLQISTKEFLNELVRRFPERPPIRPSRAQQRILESIEEWRQTICQTSRYKDDLGFIRDMHRLLLYKGYMFPEIRREDAAVLNPSDNLQSAEEMEEEEKIAQSAKLQELIRRGNPDDLREANRLMKIMAGYDTRHRTDYRAKAAEEVSRVQEKAKLLEEMLENFKPGDKLSEGDVYEELASALQNAHPKIQKMCEDESEDNEAVSKLLEINDSIHRTVQRYKLIKAGDVTAASNIPKGTLGTSTGVKKNAANELSLIDFGGEEEQVSAASNGSTAIKPPAASTLEGDLLGLSFQDEPQGQGSVALPLGPAEALLLTTEEGSSSASLPKSPSIPSTSTPTPRPSDPFAAITSGGSRTSSPFNKLQSSASSNAASSSLLDLGQLASGPPVPTLHAPHSPQQPSQSKQVTPAQTSDADDEWTFSSALPEETLPSQNTIEVLNATIGIKMQVKRFPGENKIHGLVSFSNNTPHAISELHFQIAIEKVQEALSLFPFSCLTLILFAVSQQPMGLRGIWMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLF2</accession>
    <name>D4DLF2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017975.1">
        <property type="nucleotide sequence ID" value="XM_003017929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLF2"/>
    <dbReference type="GeneID" id="9579853"/>
    <dbReference type="KEGG" id="tve:TRV_08026"/>
    <dbReference type="HOGENOM" id="CLU_002643_1_0_1"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118011" checksum="B3BBD9BA96204195" modified="2010-05-18" version="1">MLVDQATQVADDSFNPMPTSPPGTQQTDNKPVVNDTVAKPSPTVTGGTQTDSHDEIRHASPPPILGRRPSTVLELQEEAEDDQPIKRQVIHESLDFTKQRPMETIKLKEPPPVQHTKPRGKPQQQQQQQSQAQDSSALPTPKVFHIRPSSISPNRLTRFSEHLEIPDSEKNLHNPPPRSLSPAKPALKSTPSPSLGTRPERLTYQPGQPGSETSEGTSLVSDDGSRAGSKKRHPKVSFEDETEVIGHGISPPTSPESLTSQSPRAHTPRSWSDSVIRSKFGDDDLNDFEQCFTPRPALPSFGSIRGRKPSRSKDFEDDPNPALEISSSSADHAIGGILSTAGGRDQSKHDANTNLQLPPEVTSLESTGYSSLSDDTSGDEGPELQYFPAHLDSKRDDTPASKDTPSQANGTSQPRQIEAPNHLKPTPAIFIQPATPGMEEVAHSKRPSSEIPKDESTQGVNSYFSANDTKTQGREEEDGDSDSDSGNSVYSDAYEDLSDLEGDGFGSIDAIVDRSVPSVPQPQQPSVTHSQPQERGQRDELNGTAESYAAANVTPETQSQPAHQRQPEGTAEEGESRRQALSTAKTAGKPLFEEKTTSPPAAPSHPSPNICSSGQFNRHSPALRPILESNGSSENKPVKAKGKAAPAIRPQRTMSNASDSSSSFKRPKRFRSTGRYTLRRTMRTTSADHMEVLSDGGLPPTKTIDHSLNRRPFSSNDTRPTMRTTLRQSPSTATSRFSVLTGRGKSAKANGSSAKHQPFKSRYEDSSDEEGGAIKLRPVRGIPRRRNETEGDSTDLDDSSEDEATRHVLRRKKSIKGDSRAIKDPAVAAAVARLMAPRDIEQSAAISAIPGPEQLPEFNIKHRSGLLGRLHLPKNNKLRRESMLRKPDITLEQPRLGLEQASIASPGLPEEDYARSTSVNGHVLESSRSDWQPLSPKLQKRASKLMHRPAGDSWPLRSNGHTAFSLPSSPSTTERRRPTVLPMQEITNGKDSDTRPRTADSVAAQNTTQPTNTASVPNSPMSPARAERSLWASRFRPSRRATDDNSTVSAVSEVHLSSLRNEIPRHEKKGRFPRLKKVFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX6</accession>
    <name>D4CYX6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025810.1">
        <property type="nucleotide sequence ID" value="XM_003025764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582053"/>
    <dbReference type="KEGG" id="tve:TRV_00013"/>
    <dbReference type="HOGENOM" id="CLU_251800_0_0_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="617"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1247"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1441" mass="159498" checksum="FECB2B3ABF8A4A02" modified="2010-05-18" version="1">MGSSADENAQTRDAPWGDFPSPLRARGFTGSREDIQAASAYLFCSAAARLQNLDRVEETVTNPAASDSALAQAPRTQYPVPPPLRERDLNEGNPEVTSYLQSESYEEFSAQANPVDNTQYLSSFETYHSNNSHLTFASGQDRHPDPSPSTPLPSTRLPEETTVPQNTPTSHHHQPNRVVDPTPVRETYRAFPRPREPQVQTSSTHKFDPHSRPFPLRRVCTTENYHYHEAQPVKSSRYRQYPRPQRLYTRGEFQARTRELLKHDTTPGGFNDFDPDFSNRKPAGTSTLKQVRSFPDPRSLTDPLPKSGRDFEPNSRQRSSTATKRSQPHPPKNKPYEFKTDSFPQPHHFSTLNPKSPYNPLNFIPGGVNSSGYLYLPSPASQPAARPEPDPAPPADVPAEPRAFHAQGDFDFPFNKPCSAEPAPDTCPAPPRPTFRLELPSAQEIKDRKRKKSGARRFTSSLKKLFFRKTKSESENTTAAPGQANADYSLAPQAEDTSKGRPSATRLGRFREELGEADSTQAAQLEEQLKGVDSAQAERFKEQLRKPFITVTVDPPPENDSTPPRDTPNMFSTGHLDPSSAVMAITKQKAEAMRLAREQGFIVREMCRRAKTDVPPYTFEELIGKGSYGRVYKGHHALTKSVVAIKVMDIDNLDYETTRDFKDESIKDFIHETKVMSQVKEAGAKNINIFIEAVSIHSQLWLVSEYCPGGSIKTLMRATGDKLEEKFIIPIAREVAVGLKAIHDAGIIHRDVKAGNILIHEEGNIQICDFGVAGVLQSQRDKRSTWIGTPHWMPPELFPNKPGDEVHPYGNEIDVWAYGCTLFECATGNPPNATLRERMQIGRQLNRFTPRLDGENYSEELCGIVSYALDADPRSRPAMGDILNHPYIAGSEQSHPTEGLRELVKIYYQWSQRGGQRISLFNPGGAVAAEMPGARGPLDDEAWNFSTTEGFEKRFSIIDLDQISASLAALENEQSLEPNYTSFDQFNMEPEERELTAEEKVNFDERVKRGAAAMEGLFDEAKPKYKYETKNDFVPIEQARKFNDLPLRTDTDRSSVASTFIDINLGVYDSSHYASASGSANPPFQLADADTIRANRSSSRSYRASSSAGSEPHDEFPQNRGPRPPTMDWKFPTTATSIEESESPNLADDEIAPHDAEPLESREEKRDTRAWTFPVMTAEEDGPGDEPIDETAHVETPGAWSSDNESTTAQAMFPLQHSPSVLSRAIGKSDALPMAKSPDHHALASESRPSTAESKQSSVSDADYNPFRLDREGSVSGPSTTTQRRGLAKAPPIREPGYPYFPQDDEYGNSLSRSNIANGFDEHHVSSLPESETLRNGSVTAAPLSRSDSSSMYSQNGNSNGNIRGSLNATPAAENSSLTQFPELKPPSIESLTEGASDEVVTAELDRLFGELMHGLAATGEAIQSTDSAKAAESDVRPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ09</accession>
    <name>D4CZ09_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_00046</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025784.1">
        <property type="nucleotide sequence ID" value="XM_003025738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ09"/>
    <dbReference type="GeneID" id="9582027"/>
    <dbReference type="KEGG" id="tve:TRV_00046"/>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="15">
        <location>
            <begin position="335"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="485" mass="53698" checksum="4DB59E9A722EBC98" modified="2010-05-18" version="1">MTLNIAYQPTAEVADLKALYVGRMLQDVDGPKPVIDREVARRNCQVMLDAALALDVDFRAHVKTHKTTELTRFQVGEKSDTVRLVASTLVEAEQLVPFMKECQTKGRKVDLIYGLPVQPSCFPRLAELGKALGHGAVTCLVDSVEIIPFLSRYHALCGKRLGVFIKLDTGYGRAGVTYSSAQFNAIVSELYALEGREPHLFTLRGFYSHMGHSYGSNNPSEAMDYLRAEIEGCKLAADRASAIPPPTPFDGETNYSQRRFVLSVGATPSTTAAQNLTEHGTLSLPGADKAKDLIDQTKQTYDIELHAGAYVTLDMQQLAARARPNSSHLSFDDLALTVLAEVGSLYMHREHPEALVACGSLAIGREPCRSYEGWGVVTPWREQQQQQQQANDAAPAADEGTGFYDPDGDKTGWILDRVSQEHGILRWHGSRQNMRTLRIGEKLRIWPNHCCICLAGFTYVLVVDSTAQGSEKDRIVDVWQSWRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ25</accession>
    <name>D4CZ25_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025735.1">
        <property type="nucleotide sequence ID" value="XM_003025689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ25"/>
    <dbReference type="GeneID" id="9581993"/>
    <dbReference type="KEGG" id="tve:TRV_00062"/>
    <dbReference type="HOGENOM" id="CLU_721967_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="42487" checksum="F55C5BD068C9F176" modified="2010-05-18" version="1">MFAKMFGTIRYDKDTNSRKHVELQSASGFKARGLDHFFQHYGLGHTGRGLIFTSLLRNDEDEYLLTSPQLKCSGDKDGCGKCQAASVTCMYRDILSIKDSRKTSKRVRPSNNHLPTPNSCQASYGSQQLSIGAEIDQESTQSMSDSEPLNLPCSSSEEFAELNNIHSSTNAENIFDAVLNIQVPYHHTNTPSQPTRFNENTQERRSEWSSFPGGNSPSPLGTNREPASKCDCLRDVALFLEAIGVESTETRADILLKVRGDNGMFLAVVLQQLVTLTRTASDKLLEWNHEQSNRRGSSSETHIPIVCIYQYRIEIPDVKVSLILHVALLHFFGLQGLSNALKEKLRSNSFAAQLVTDCESIIVDTIKIIQEKASNSASMGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZF6</accession>
    <name>D4CZF6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00198</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000013">
        <property type="protein sequence ID" value="EFE45020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025631.1">
        <property type="nucleotide sequence ID" value="XM_003025585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZF6"/>
    <dbReference type="GeneID" id="9581867"/>
    <dbReference type="KEGG" id="tve:TRV_00198"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_0_1"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="142"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE45020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="468" mass="53600" checksum="3B49F08126EACF0E" modified="2010-05-18" version="1">MLDIADLIPERGGDPKKVKESQRRRFASEELVDEVVALYEDARRTRYEATQVGSRINAVQKEIGMKKRNKEDATDLLAEKAKLEEEKKAIEDRAVQCEQLRDRRLKTIGNYVDDSVPVDKNEDNNAVLRTWAPPDVKVEKRDCLSHHEVLYRLDGYDPERGVKIVGHRGYCLTGYGLFLNLALVNYGLEFLFNKGYKPNQPPHFMLRNYMAKTAQLEQFDEELYKVTESEDPSTDKYLIATSEQPLSALHDGEWILEKELPINTCYRKEAGAHGKDAWGIFRVHQFEKIEQFLITKPEESWKAFDEMIDTSEEFYKSLKIPYQVIAIVSGALNNAASKKLDLEAWFPFQGEYKELVSCSNCTDYQTRELDIRFGSKKLTDVKKNYCHALNATLCATERALCCILENYQQEDGIIVPEVLRKYIPGNPEFLPYVRELPKDTTSQKVKAKGGKADAAKADLAKGVENMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZQ3</accession>
    <name>D4CZQ3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transesterase (LovD), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025533.1">
        <property type="nucleotide sequence ID" value="XM_003025487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZQ3"/>
    <dbReference type="GeneID" id="9581770"/>
    <dbReference type="KEGG" id="tve:TRV_00295"/>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="63"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="382" mass="41996" checksum="B466E5BEC02FDA59" modified="2010-05-18" version="1">MDLTHILERTCSKSDCRFHAAVFTAANRGRTGKFWIVEMIMITKGVLDQVLHSIPYGTQNVDGSGDAVTERSMFWCASMTKIVTAVAVMVAVEKGLVGLDDDVGAILPELAEPDIIVGFEDGNNAVNSSVKRWAEYHNHTATTDVTSRETYRLPLAFEPGKSWGYGPGVDWAGCVVEKVSNQKLGDFMQENIFQKLGITATTFHPENHPEFNARRVELCQRAPDGSLSMTPVPYTIPAKDDLGGIGLYSTPKEFTRFLQMILRSGENVLRPESINTILSSQLECNKEINAIRDRGPKIMSRLVNPGKMIDMGLSASINLDRVPGARYPGSISWAGAANAFWWLDMKAGICGTLFMHSFPPFDIAALDLLDELEAAVYTIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZT6</accession>
    <name>D4CZT6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000017">
        <property type="protein sequence ID" value="EFE44888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025499.1">
        <property type="nucleotide sequence ID" value="XM_003025453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZT6"/>
    <dbReference type="GeneID" id="9581736"/>
    <dbReference type="KEGG" id="tve:TRV_00329"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="626"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="807" mass="87734" checksum="8B9DBECEDF1D9C14" modified="2010-05-18" version="1">MEVPGELSIDMADTINTDQPDDGLSQSFSQGQESSEEPIFGSVNDSPISSHSRLRSIDESPRGSRPGTANQNTSREPGNGSGASNKPGAPTDWYIEGPGRRVGYDDLTAIDWIFEYTKERQRIRHLNANNPGLLGTFRQLLDASQVWMVLVMTGLAVGLLAGCIDITSRWLADIKVGYCKSGVEGGKFYLNRSFCCWGYDDPANCKHWISWHDAFKISSKAGGFVAEYMVFIMYSILFATCAAVLVTSYATHAKHSGIPEIKTILGGFVIKKFMGLWTLMIKSVGLCLSVASARKREVLSAAAAAGISVAFGSPIGGVLFSLEQLSYYFPDKTMWQSFVCAMAAAISLRAVNPFRTGNIVLYQVTDSQRWHPIEILLFILLGIFGGLYGGLFIKLNMQISKWRKSRNFSFPVLEVLFVALLTGLINFPNSFMKAQLSDLLQALFAECSKTPADEFGLCKGNSDFAGVFWALVFAGTLGFLLASITFGLDIPAGVILPSLAIGALYGRALGTMVSVWQKSHPNSLLFSDCEPGAPCVTPGTYAIVGAAAALGGATRMTVSIVVIMFELTGALTHVIPIMIAVMLSKWCGDIFGKRGIYESWIHLNEYPFLDQKDDTPPPDVPVSQVMTSINDLTVITAVGHTVESLRNLLSSTSYRGFPVVSDMANPTLLGYISRNELSYALNVSSSRHSGSLSPETQTFFSHQPFADPAETLDLRPWMDQTPITMNIHTNLLIVLNMFQRLGLRGRLEGFLTKKDIWYILNESSKADPTSGIGGGILQADGTGEARGLLSRADNPMLVSPVDDGNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY1</accession>
    <name>D4CZY1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025435.1">
        <property type="nucleotide sequence ID" value="XM_003025389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY1"/>
    <dbReference type="GeneID" id="9581691"/>
    <dbReference type="KEGG" id="tve:TRV_00375"/>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37572" checksum="EF5BBE23BCCBDA3D" modified="2010-05-18" version="1">MNEEAQFWLAQRIPIDKPSSAVLGHNTLLGVVAGISSRVLVGLPMGRDQDWLRTVVGYTIDVMQASAGLRPYPTLLRPLVAPWLGCIKRLQRHLDTAHRCFGDVFAQRLADPSRTEGEQNVIQWMAEAATGDDRNPEVLVKKLLFITLAAVHTSTMAATHALFDLCVMPEYMPLLRKELDEVIAKHGWTLAAINNMPVLDSFLKESQRINHPGLRSFISMATSSIARDPEHYPEPERFDGLRFYNMRKASNGDSSKRHQFVSTGPENLAFGFGKFACPGRFFAAAQIKVIIATIILRYDVSFPDGQKTRPRNTFVGESIGPDRRQVIVFRRRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0B8</accession>
    <name>D4D0B8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025333.1">
        <property type="nucleotide sequence ID" value="XM_003025287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0B8"/>
    <dbReference type="GeneID" id="9582944"/>
    <dbReference type="KEGG" id="tve:TRV_00513"/>
    <dbReference type="HOGENOM" id="CLU_323426_0_0_1"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="201"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="875" mass="96511" checksum="6334AD47E80B6EA0" modified="2010-05-18" version="1">MSSSSHSQYLFLQSCVNIYKDCVYDLEAAKGRPKRKHVESRDSKLGSDRDHAGKGAGSQDGKSTGQWDPSLQGPLMGDDLKAMFHECFISKVGMRATIFQGAIAAGHERLKQTGSNSASHEAPQRISYDGLMSSMTREIVEMISLRFGDLNCEVEDNFPRRYCITSLARDTTQEMFDNTVPRKNPLKSYSSHRILQLIDLWFSVHPLSSLISKTLLLSSLKNSTYDEALLATILSDACLVHENGQNYDTEGQLLFEFATYQIQNRSVLNRDIASSQALILMAWREICMGNARRGSCLTAYACRIVSELHRGLNQGVSSNGTKLNGIDVRYVDGELIRNIYWVCRSTTVWSLMQIDQPYNLLLPEQTPSQFPFVDESTSMTISLDLASDNVSTLRAQSRALQELWPLSQVASTAAHIYALCASPDIKDTLETVEWQARHIHQLRRLLSFQLELPTLCGKIRHILLEAIRQVKLEVAPGSTQAVVLIAYHTMIVHMLFPQRQTSDSVIIMTPERINEFCQSANALVAISHFVISPQTTSLLPGPGLKTKNVSDIFALGLDACSRALAYIHSRANCGRDEYQAIMAKNRQLFYLAQHLHDISRGELSRASATMRTIKKRLKFAKVVFSSINESTPPLVHSDPSPIAQFRSRIQNLSQSSNTSVSGGLSQPGSPIPDDASYLSTIPNQLPLDMFLGSDTSPVSSQDGFDTLHMHTSSSSLATLDHSGMTSPFTPPGMSPLQPPRKIRRTVSPPSFENHGKANMFELSEPVMSSKPEHIPRSSGSPSLNNGSVFRNGGGMGLMGLDMTPNDGHKKFLGEPMNFSQQLFMSSENDPDFGSGPLLFGSPLDTNGHGDFNGMPDLTCVEGENGFMPLDLGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0J0</accession>
    <name>D4D0J0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025269.1">
        <property type="nucleotide sequence ID" value="XM_003025223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0J0"/>
    <dbReference type="GeneID" id="9580762"/>
    <dbReference type="KEGG" id="tve:TRV_00585"/>
    <dbReference type="HOGENOM" id="CLU_030447_0_0_1"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="599" mass="64443" checksum="BC781C00149B30FE" modified="2010-05-18" version="1">MSGFSFPPPPPPPPPAQPSQPTYNNSSRGGGGGGRGNSHHRGRGRGNGPRRGGRGGGYGGDMNASWGYTPPHQHQPQHLPMHPNQGAYAYGPLPGYGGPHAPAPPPAPAPAPPPQTMHFGPPQGGYLPPAPAYADSRAWTFNPKQTYTAPAYQRPHQKHTHTQAPTHRPPKRQHDTAFTTAPLPVPSFNTLPSKPPPVQAQTKGQANPARPRKQRKHNQLGLTPKTEEHESSESEAEDVDEEAKLAGLLTKGELKFSYRGRTSTLGSTAEVQAWIEERKRRFPTQARVEERKKEEEARKAAKKQKDEEMRKQREEAKKKREEERKKREAEAAEAKKAKEKEKQQQKKGDASDVAARAKIRADKLREKLARQERKLAQAEAAAAKQQAAAEAEVEASAGAGTAAAAGQTAAGDQAQARVKPDGDEAVASTTTTPSLPTATAIALLQDHTPVAAGATKTLAPDLGNQASGADDDSGSDSTTSSEGESESESESESESGSDSDGESDSGSQPEQTSSRRQGPDRVPPRRRCHQFARTGQCRHGSSCTFLHEKKNQGQPKEKQQQQQRKGDKPRAGRKSLYERAASAINEDMHGAISELTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0L5</accession>
    <name>D4D0L5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000035">
        <property type="protein sequence ID" value="EFE44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025225.1">
        <property type="nucleotide sequence ID" value="XM_003025179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0L5"/>
    <dbReference type="GeneID" id="9580715"/>
    <dbReference type="KEGG" id="tve:TRV_00610"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="29204" checksum="5418DE9FF0AC71C8" modified="2010-05-18" version="1" fragment="single">QIPAAIMPIPVPKSDSLMEMFSLKGKVVVVTGASGPRGMGIEAARGCAEMGADVAITYSSRPQGGEQNAKELMEKYGVKAKAYKCNVGDWADVDNFVKQVIKDFGKIDAFIANAGRTADSGILEGSVESWNEVIQTDLNGTFHCAKAVGAHFKERGTGSFIITSSMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDKKVQDLWLSMIPMGRNGDAKELKGAYVYLCSDASTYTTGADLIIDGGYVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Q4</accession>
    <name>D4D0Q4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025194.1">
        <property type="nucleotide sequence ID" value="XM_003025148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Q4"/>
    <dbReference type="GeneID" id="9580687"/>
    <dbReference type="KEGG" id="tve:TRV_00649"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="140"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="673" mass="75717" checksum="C4CE8AB14D5C39E3" modified="2010-05-18" version="1">MIPREIIGYTSSRSSAELQSSNTKGSAATASDHHTERLNSFTSRRESLTAAERARRNLNAKLANPLAGLSHATLRSRGSRYAQKYQIGDDDDVRAFELGAVLAQDPEQFEKVEGLTKEELDVLRKEFTNRWSQPKEMYLVIVLCSISAAVQGMGKLSINLPWKGEIRWLTIQADETVVNGAQIFYKPQFGIDDDDFRSTWLAGLINAAPYLCCALIGCWLTVPFNHWFGRRGTIFITCCFSTLACFWQGFVNTWWHMFIARFALGFGIGPKSATVPIYAAETSPPAIRGALVMQWQMWTAFGIMMGYASDLIFFNVPDIPNVTGLGWRLMMGSAMFPAILVCCMVFICPESPRWYMSKGAHHKAYQSMCQLRFNKVQAARDLFYMHTLLEAESTMKLGQPKILELITVPRNRRALVASEIVMFMQQFCGVNVIAYYSSEVFLQAGYSELSALAASLGFGVINWLFAIPAVYTIDTFGRRNLLLVTFPLMGLFLLLTGFAFWIPDHAAQTGCVALGIYLFGIVYSPGEGPVPFTYSAEAYPLYVRSYGMALATATTWFFNFTLAITWPSLLRAFTPQGAFGWYAAWNLIGFVLILLFMPETKGKTLEELDQVFSVPTKVHARWALKQIVYVFRKYVLRQKGLKEALLYEKPEGKPISQSMEERVVGSPQFFGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0X7</accession>
    <name>D4D0X7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025065.1">
        <property type="nucleotide sequence ID" value="XM_003025019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0X7"/>
    <dbReference type="GeneID" id="9580577"/>
    <dbReference type="KEGG" id="tve:TRV_00723"/>
    <dbReference type="HOGENOM" id="CLU_1950373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="129" mass="14509" checksum="FBD68BD3814EC04E" modified="2010-05-18" version="1">MQRTMRGGQYRRMEWEGSPENPPKQEKGDGDSRPERTASQPASSQARTHASKQKQQLQEYSVDAAAAAAAAVKRCVESRALYINAHKHDICISPQLDLEEWEKKSNNLKQAYIQMAVNVSSRACLPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Z0</accession>
    <name>D4D0Z0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025078.1">
        <property type="nucleotide sequence ID" value="XM_003025032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580558"/>
    <dbReference type="KEGG" id="tve:TRV_00736"/>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1332"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1948" mass="217528" checksum="8D7C436DDD3B5140" modified="2010-05-18" version="1">MALRRLPGVRELDVLLALCKAAGSVQRGDHAAKLVSLLAGYLPTLHTLRIHSSPFLHIYKPSPWETLTHDVVTALLSLGSRHKSLQDDVHEAIDEYLENCHQATDRLPAVFDADGTGIQVESHESTDVTTLMVSLVGFLRASSEFPHFWAPLDRLAIVKQLHIILSERFLVAVETISSGIRNSRSPDPLLHDWRRYTRQYAADGRPLGSMLLQQAFMGFLKSCTSPVENDKTPPLPDDTLLSRYADSSYVAKASDRGMMSLVKYATEIAGDQINLLEEGSDYLQVSSTWQQRLAFLVKALSIMCSINCIMVDQDSVDLDLLFTSLDNTISDPDQMMNKDLATVVLKAAVILARLSRGSANGLTRSLLRFIVQNGQSSPVVALAAQCLAQNLRLLSQDTVIGTLYSLGNVLSSGSAADKAATALTAESGTGYSHSIETRAPPTNESFLSLAIDGEGDTSVTARNVVHAIVTIATYSEDSKIVALAQSILVQKIGKANVVVDAYIIQETAALSLKSEPAEFRLLLKFYSRLLRDTVAQGNNLMLEAIHKARNYLAANLDRNSEVFKIYLVFLLESLVNQGAAVEREKVHPEDLEATAKQIAPILKPLAILLARAGRLDQLASGVCDNDDITDMLRDAWFNIAAHDISLHSELGKANYEQLRILAEHSPPLVSENRAELLESDIELNTILRRGQSPQTTVEKKKNLTAELPAQEHDIRRLNYPKALFLNATLLIETLRANSGDCTKVFTYFLDPTLGASEMGNCMRAIADKVVTVYLEKTLRSTSVKFSAPYIAKQLADTFTACCHRIVQVQQTATLAANKIIMQCPSALCQKLSLFTLLDLITLLWSSCMDEEMDEFAWNSTFTSSRRTVQVVLSDNYDFRRRTLKNLHNSARTWISNVMNIAPLDIKGLLQTYLSDYDDDGVYGNINMGRSLALEMGSAIPFADQRLGSIDNPGGTVLNVASDFISQYTTRQEYRYSEAAPARRGKSPLAISYGIYLFYLGSGINLLTSSIGQSTTARVTDYPDTVQEALAALEHQIRTEKHISLDLPRHILRRAAALLCNTDDSHATIIAYLVSIPFQIFTKESIRMGIALWLGVINEKPSMESRILVEVAQAWERTIRRKQGIFDPNFKHKNPFMNKLESSPSDKEAIVRRHKKAQNIISPHFLALQFLESHFSASRLGSLNTQQVFRRLVSETLIALRDSTGHPLAREIHFHIILFSLKVLHSFSGQSNVSSWKLKDQILSAALSWFSHSPRWSFGGNRLQLKAEDQVLHDIESMLETVSWKEVVDSKSHKSLQAKHDLLLILIGNERSRLKVWLSPLDLEKKSYFFYGTGNKTVTEETVAGLLRLAWNENPSLALQLGSRFPSAKLRTDIRWLLLNFPEKALKEPNALEILLGSALPEDVSFQLKYLLYWEPIDPISAVTYLLPAYGNHPFILQYALRSLESFPVDVGLFYVPQLVQALRYDALGYIERYLSNTAQLSQMFAHQVIWNMKANAYKDEDSQIPDPLKPVLDRFMDPVIASFTDEDKEFYEREFAFFNEITGISGKLRPYIKRTKQEKKEKITEELRKIKVEVGVYLPSNPDGVVVGIDRKSGKPLQSHAKAPYMATFRIKKTRNIEEGSNAVTPAEEADHEEANLQLSQVKESTVQSKRESLAASQAGTYEVWQSAIFKVGDDCRQDVLALQMIAAFREIFASVGLDVFVFPYRVVATAPGCGVIDVLPNSISRDMLGREAVNGLYDYFVSKYGGEQSIKFQEARSNFVKSMAAYSVISYLLQFKDRHNGNIMIDDAGHIIHIDFGFCFDIAPGGVRFERAPFKLTTEMIAVMGGYHPSSSTAASATASTATTSTSHSASYNNSQSYRWFESLVVKAFLASRPYTMKLSNIVTLMLDSGLPCFTPHTLTNFRDRFVLEKSEQEAAQYMRELIRKSYASMSTKGYDQFQLMTNNIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D111</accession>
    <name>D4D111_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025099.1">
        <property type="nucleotide sequence ID" value="XM_003025053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D111"/>
    <dbReference type="GeneID" id="9580591"/>
    <dbReference type="KEGG" id="tve:TRV_00757"/>
    <dbReference type="HOGENOM" id="CLU_019706_2_0_1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055149" evidence="2">
        <location>
            <begin position="19"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="99"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="586" mass="63939" checksum="5A15FF4298E0EC74" modified="2010-05-18" version="1">MVACFLWLLLPYAATTLSASVPGCVPSGALLPRPTELNQSQNIKDATERLSRSLDDAVSGRIKAGWDIANTSFSVSIVSPNGGDPKTGILWEYHHLAEKNVNGTKHLDSNSQYLIGSVSKIFSDLLLLKSDVDLQDPITKYLPQLKNASSPIDWDNISLLSLSEHLSGIPANTKPLYRALGFPPLNKSDYPPCGIADLNKGCTPEELLTELVDSHPVAEPYERPVYSQLSFTLFSLALANETGKDYAQMLEEQVIRPLSLRNTGFSPGEDKRAVIPNVEQQGWGADYGYNAPGGGLYSSLNDLSTLVTKILDYSILQSPQATRRWLQPRSATSSLNTLVGQPWEILRTSGMTPKYPHTIDIYGKSGGAPGYISQINVIDQYGVGVVLSTAGPLDSKAAYIINEAVLSAILPAVEDEARKQAGMYVGEYTSQKGDNEDATDNAPIKLKTIIDNGTGIKLESLSRNDSDILEGIRKIWSATLSTVGQLASEMRVYPTGIERLATNDKSLVEQDWRINFDLIPNVNEQASDLPGLGKLEALCTSWQTVDWLYYAGVPMDRIVFIVDKEAGRVVGVEIPFLRSGFIQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D126</accession>
    <name>D4D126_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025114.1">
        <property type="nucleotide sequence ID" value="XM_003025068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D126"/>
    <dbReference type="GeneID" id="9580606"/>
    <dbReference type="KEGG" id="tve:TRV_00772"/>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="175"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38271" checksum="16FAA0B9AA5B0FD1" modified="2010-05-18" version="1">MATTQAQPAASFAEAIAITPLSSHTYSANLRTEWCIGTVPHGGYVTSIFYAVARKHMKTTHPTYHKGAPDPITVYLAFIRRTNIGSALFTVVDTKLGSRTSTLHITLSQQDPDGNRREEVAGYITVSHIASEEGPSIERAFALTPPAPMVDLKQLASTGRSGEWNGFKVAFGSMRKASRHVEFYAPSTSAMVSRGFVEQWARFAPYGKVERWTDETLGFLADMFPMMLESFDDKPWDKRSKEEKEKEKYAVGKNGKLSPKGKFWYPTILLNLDVKKKLPAEGAEWLYSRVQTKKLHNGRMDLDVIIMDEKGEVVALSNHVALVIGAERNLSARKGSGKPNGESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F2</accession>
    <name>D4D1F2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA adenine N(6)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024981.1">
        <property type="nucleotide sequence ID" value="XM_003024935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F2"/>
    <dbReference type="GeneID" id="9580473"/>
    <dbReference type="KEGG" id="tve:TRV_00902"/>
    <dbReference type="HOGENOM" id="CLU_030043_0_0_1"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="72062" checksum="1B22B08E83D2F137" modified="2010-05-18" version="1">MLWTKGVSFSSIPPRWVLLRSYARSASSSASPSIRDIKDSRIHITSSKLCNDVLERLAPTLPNSKPVDIIDAYPGLGIWSSHFHEYVRPRRHILLEPNFRTYEAHLKPLLQSPGSRYVHAPLDPALDRTFFDLFKKGYLPEQTERTEGCTEVNDTLLVLANMTLLRSATKLRATDSRKYFESMLDQSYFHRYGLVRIIAIFPSSNLDAILPKSISRRRRTQALLECIALEANEVAGDTSETTHLTRRGLPVVQISAERAAKRNEGVVVKVPPGREPVPLELSPKPVAVNGVEHSYVPRPIHDWHREYIRAHKDLKKEEQKIDTSNPIPVKLKDLRKNFAALQKRYLYESSQIRSAHEADDRQCDIDNIEADLRKVMNGTLPVPNRREAGKIIKNLALLKEERDLILSSLGKQFIRHHYPLFVNERRCVSGSQSSPSVEPLLLWDKRAYEPLHVEKDEFSPKTPCSIVDIQPNPDSFIFEAQRQYKASNESFKYISVLTTFRALLRMFIPYPKKSIEQVLRLLFASRPMTDFPSAIPSLAEYATPKITMDAKEAASWKHVKTDNRRGVFVGYDMDCLAEATLQRIPSKLFWDIAVEWERWRHEKNLPDTLSKSLGGAFISDMNEAFEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Z8</accession>
    <name>D4D1Z8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024751.1">
        <property type="nucleotide sequence ID" value="XM_003024705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Z8"/>
    <dbReference type="GeneID" id="9580241"/>
    <dbReference type="KEGG" id="tve:TRV_01100"/>
    <dbReference type="HOGENOM" id="CLU_053544_0_0_1"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27605" checksum="FEF6FC8BF9D0AD10" modified="2010-05-18" version="1">MMKALRILSKQLPTILVNALPQEILSPSISLHLFPSTHPHLPTVKGRVPYRAALWTAPVAWGSVPIIGNVNLRIVSERVVPTGVANGSDRNDSPGGEKLVVRWVTEGADRPASKVGRGSEVDDYIAPDRADREQSTNKESPMSSSSALNGTNRGLSMLLGGEMPIFKLGKEEQFTGLFIFTFDEEGRIATHTIEHADEGNGWDRTAKVVTLTDWLLGKAKGSASGQIVPPQPAFVAGKARETSRPRYRFGPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B0</accession>
    <name>D4D2B0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar sorting receptor (Mrl1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024644.1">
        <property type="nucleotide sequence ID" value="XM_003024598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B0"/>
    <dbReference type="GeneID" id="9582819"/>
    <dbReference type="KEGG" id="tve:TRV_01213"/>
    <dbReference type="HOGENOM" id="CLU_064145_1_0_1"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055182" evidence="9">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="32"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="263" mass="28838" checksum="1ACE2EFEC1B6A54A" modified="2010-05-18" version="1">MHINSLNSLLQVLFLSSVAWGAAEEKPKAPEKPCTIHSPNTGLYFDLNAISVQLDKKDGKKSHADHQRDESWHVKGHDYGANFTINICAPVVENLTDVVGVDEKRWQNISAYYEMDGETYSIGQQSSSLLFRGRKLVLNYTDGSPCPSPSRGNKLFRRKIVDGDDDDDEDNDNKDGGKKGDDDEKKKGDDKKKDPEDKVERRKSTLMSFLCDRDLVTPAATFSFVGSPDSCSYFFEVRTAAACGGVAASTDGGVGPAGIFGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D346</accession>
    <name>D4D346_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024305.1">
        <property type="nucleotide sequence ID" value="XM_003024259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D346"/>
    <dbReference type="GeneID" id="9579463"/>
    <dbReference type="KEGG" id="tve:TRV_01503"/>
    <dbReference type="HOGENOM" id="CLU_000288_79_2_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="282"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="682" mass="71374" checksum="2DDF35A698F25BA0" modified="2010-05-18" version="1">MEESNQVREGVEMQGVDGAADTPSSTSTTTTTTASASASASVSTTSTSAPSAAAPIMTAPAEGRPRLPVMPATTASIRTTSGMMTPSSTPLGHVNAARRPGPLPARGSQSSGLSQDIQEKMKAFSLSRQGAPGNGSNGNERLPGIPIAAPQATSPWSPPSVQGGAAAAPMGRTPTPKMGGGGLAAKRGMAGGMKLSNVTGQPPGAAPGIPNASSGANGSPASLSKASGTPQSSNTPVSAFSKYSELIDTKAGTINFKNKAIIHGGGIDFSSGQSFSISLDDVESLNELGKGNYGTVYRVRHCRPKIRRPGLGLKGSMVGNLPDSNTNNNINNNNQNNNDSNSLDTTSNTKKNKGDLTNVIMAMKEIRLELDEAKFTAIIMELDILHRCISPFIIDFYGAFFQEGAVYICVEFMDGGSMEKVYSGGVPENILRKITLSTVMGLKCLKDEHNIIHRDVKPTNILVNTRGQIKICDFGVSGNLVASIAKTNIGCQSYMAPERIAGGGHPGSSGGGTYSVQSDIWSLGLTIVECAMGRYPYPPETYNNIFSQLNAIVQGDPPTLPDPGFSPEAKDFVASCLQKNPAARPTYANLIRHAWVEKLMQPPTATPEATEAAEIIGSEEPTDARSPDGPDYNTDTYDKEVAAWVIEALKRRAGEANGRERPALHAVALDAVPKSPLLEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3F9</accession>
    <name>D4D3F9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024268.1">
        <property type="nucleotide sequence ID" value="XM_003024222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3F9"/>
    <dbReference type="GeneID" id="9579388"/>
    <dbReference type="KEGG" id="tve:TRV_01619"/>
    <dbReference type="HOGENOM" id="CLU_761167_0_0_1"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="364" mass="40414" checksum="285D7FAFDE9B0562" modified="2010-05-18" version="1">MDPLPRGSPCPVKAMVLATIRPVRVKVHPTVNPDQKKADDIGDLTLLEEKAGIAEEADMTNTMRSLAVANIASLGDHALEALGFMGAMDGSRKQGDRGQHRRYEYGDDHRDRRGHDHHRGYDNHRYDYDDRRQDSSRGRNHNRSSSLDPRAHGYRDDPNKALQNAITAALTAGVLEAYRARNDPGDWTGEKGKRVLAAVASAGGTEKVLDRGGASKSTKRHILESTLAGLATSHLVGGESGRHRSHSESHGRANTGATAALLAAAGKKAFEHYQSRSRESGRHDYYSDDGRQGRSGRSNRKRSKSLTDYVAKGMATLGLDERGRDSGHGNSHRRHRSRYSSPPSEYEYEYSDRPRHTRRHHDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H6</accession>
    <name>D4D3H6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024203.1">
        <property type="nucleotide sequence ID" value="XM_003024157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H6"/>
    <dbReference type="GeneID" id="9579241"/>
    <dbReference type="KEGG" id="tve:TRV_01636"/>
    <dbReference type="HOGENOM" id="CLU_2529100_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="84" mass="9656" checksum="743E1A53FBC6B991" modified="2010-05-18" version="1">MEADMEGLEAGLEDSKAGREISAWDSLLAGGRTWPWQPAGDTLYRWLFFFSYYYSSTTILSLLLPLLLLLLLLLLRIYRVLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I2</accession>
    <name>D4D3I2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024209.1">
        <property type="nucleotide sequence ID" value="XM_003024163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I2"/>
    <dbReference type="GeneID" id="9579247"/>
    <dbReference type="KEGG" id="tve:TRV_01642"/>
    <dbReference type="HOGENOM" id="CLU_109501_1_1_1"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="177" mass="19354" checksum="6632CD8DE4F58B22" modified="2010-05-18" version="1">MSFHAPVLRAGSKAASSSTTFICTQCRNATLLRRPKRPYTFTQLIALSDGSTFTHRTTSPQAVYRSTRDSRNALLWNPSSEKLLNLEDDEAGRLAAFRSRYGRGWDSTTKISAEDAAAAEDLASAEVGTAATPQQTAKTPEKEKVVESEFEEEDEDSLLDLISSFGQENPSSGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3K2</accession>
    <name>D4D3K2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000085">
        <property type="protein sequence ID" value="EFE43552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024163.1">
        <property type="nucleotide sequence ID" value="XM_003024117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3K2"/>
    <dbReference type="GeneID" id="9579201"/>
    <dbReference type="KEGG" id="tve:TRV_01662"/>
    <dbReference type="HOGENOM" id="CLU_047849_0_0_1"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="29718" checksum="00E3BA8BA0AADE50" modified="2010-05-18" version="1">MTSGDPGPRYKLQITAGPTYDTSTHSLVHVNTDTNLCIETEHAKYSLAISFVPKKGLTGNDLVLGNDLDRPIRDRLPPGSSYAFKFIKWWVDPGLEGDIYADKPYIYGPCLSSWNYFRVCGKEDETGNSEAEIHEAVVEEGGEGSGQAVREELQIPEDNGQRQKFFLDEQKRKDFEFEPGRIYKADFGNPYIGFSDFTIRIPGFPVPVTKYIDEKNHELRYILKNKTTGDIYFVVLFTLLMQNGAEVEPVKDESAPGEAEAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3N1</accession>
    <name>D4D3N1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024133.1">
        <property type="nucleotide sequence ID" value="XM_003024087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3N1"/>
    <dbReference type="GeneID" id="9577150"/>
    <dbReference type="KEGG" id="tve:TRV_01691"/>
    <dbReference type="HOGENOM" id="CLU_193993_0_0_1"/>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="83" mass="9416" checksum="9C5881F772B7700D" modified="2010-05-18" version="1">MSDGYNEARALRVSELINDFRTLLVHISQLKLDATEMAEVAQGYVLMRQCVAEAQELLASQFDIQSIQNLQGDGEFEKVQLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R3</accession>
    <name>D4D3R3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024125.1">
        <property type="nucleotide sequence ID" value="XM_003024079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R3"/>
    <dbReference type="GeneID" id="9577122"/>
    <dbReference type="KEGG" id="tve:TRV_01725"/>
    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="252" mass="28278" checksum="46A8595628FEE616" modified="2010-05-18" version="1">MRLTVELIQNSLSYLNPLKERELDLRENFGAAKDHDAIDFTDNSISSISNFPFSPRLRSLLLARNRVSHIQPTLATSLPNLTTLVLTANNFAELADLEPLKTFPRLTHLSLLENPVTRKEHYRYWIIWLAPTIRFLDYQKVKDVEREKAKELFGPSTKQPTALASKILGIKSRAFDVSAALGAASSTSSPGGAGSEKPLRVKLTPEERKRVEKMIREAKSLQEITRLEKELNEGRIPRGAGDADGDKDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R6</accession>
    <name>D4D3R6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_01728</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024128.1">
        <property type="nucleotide sequence ID" value="XM_003024082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R6"/>
    <dbReference type="GeneID" id="9577125"/>
    <dbReference type="KEGG" id="tve:TRV_01728"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="558"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="855"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="412"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="847"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1109"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1116"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126997" checksum="1C8FE11539E8C5BA" modified="2010-05-18" version="1">MGALHDGHMSLIRQAAQENTDVVVSIYVNPTQFGVNEDLDSYPRTWNEDLEKIQALNTEFESKSSPGSGRVTAIFAPTTKVVYPTLPPTSELNGNGSFVTITPLATKLEGASRPVFFRGVATVCTKLFNMVTPDRVYFGQKDVQQSIIIKRMVQDFHIDTEVRVGPTSREPDGLAMSSRNAYLGARRRNVGLVLSRAMRAAEAVYLSGKKSRNEILGAANSFAQSTLAEQELLPAYKRARFEVDYISLADPESLEELDHVDESKGAVLSGAVKMFPLEESQEGEDCGLGGGKVPIMGPPYILWSCGYTAIYSYNSERERELGFYYQNGQATFFFPPSAAKLKTSIFTLQLQRRREQKREINETIPKCSALTLVIIMADDGMLMNFDVGDGIISSQQKFKGGKWKDRLVAKKIADHRHKKSKQPFTADDSRRGERGGEADHGGVSSRPPKRQRLNNGDFQPSTATITGVSNNSSSKYATGPQREVISSLFSYNPVAKTVPTVEESTAHDDAEATKASNAPLVDGIDTFTSLGLSPELAAHLLTKLKLKNPTAIQKSSITQLLKENCDGFIQAETGSGKTLAYLLPLVQRLMNLSGRKSAEEGQGQATPIHRDSGLFAIILAPTRELCKQISVVLDSLLNCAHWLVAGTVIGGEKKKSEKARLRKGLNILVATPGRLADHLDNTKVLDVGLVRWLVLDEGDRLMELGFEEEIQNTIKKLDSKRRPTSKIENLPPRRLTVLCSATLKMNVQRLGEMSLKDAVHIQADPADEIEDTSSQAGDAQKSLEFSAPAQLKQSFAIVASKLRLVTLTALLKSTFIRKGTVMKAIVFVSCADSVDYHFEVFTRKSDKSTESVGKGEKEKQEEEKEEKDSSAEAAYTTNSATQGTVSESPTLSNPNNSVILHKLHGSLPQHVRTATLSAFAKQKDTSVLICTDVASRGLDLPNVDFVIEYDPAFSADDHLHRIGRTARLGRDGRAMIFLLPGSEEGYINVLKRGYRDNNTKAVTRSDESDILKRGFGRTNGKGWEEAATEFQLDIERWTLDNPSILEMARRAFQSHIRAYATHIASEREYFNIKDLHLGHLAKGFGLRDRPTKINVPGLRTGKEETKKAFKANRTVDSSDKKNDSGPKNDSAADKMRKKMREHMAAANEFNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U3</accession>
    <name>D4D3U3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCCH zinc finger and RRM domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024086.1">
        <property type="nucleotide sequence ID" value="XM_003024040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3U3"/>
    <dbReference type="GeneID" id="9577074"/>
    <dbReference type="KEGG" id="tve:TRV_01755"/>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="359"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="81128" checksum="3D09C4E247C1AC2A" modified="2010-05-18" version="1">MQFTEEKAAEVKSWVVKKLEDIDLYILNSSDADSEVLADYVLALISTDAPDDEIRKASVENLEDFLKENTVPFVDEIFEKFHPKPEQRALPANTQQPEMSSPVHNPPFVQQPPSADMMVEFAQAQQGAMGQQGSAPFDNNDQQFNTRKRTFNDSQGDDQSPYQRNADRPHKSARGRRGRGGWDSRQYPSPHGQGYSPSMPGGFHGGPGTPQPGFPPFNPNDPIAQMLSMSGINFPQIPGMPPMPPLPSLNGQPQPSGSPPNKISERCKNYDNMGFCVLGSTCPYQHGQALSKDDEYDPTNSNIVSGHSANGANGHGSSGRGDRGRGRGRGRNDRGGHGSQRRNRAEFSHAGPNDDRRITTIVVEQIPEDKFDEATVREFFSEFGEITEVTMKPYKHLALVKYDSYDAAHRAWSSPKVIFDNRFVKVYWYKPTESRGDSNGFKKTSADEPSFDMEAFEKQQAEAQKAHEEKVRKRKETEEAILEHKKKTEELLKRHKEEQAKLLQKLEAKGAGKDTASPESGNSANDKTASLRAQLASLEAEAKSMGIDPNAQPESPFGRGRGRGYAGFRGRGGFAPRGRGFDPSFRAGFRGRGAFRGRGGVIRLDNRPKKVAISGVEFDTNRDEALRQYLLGIGEYESIDPSPDRPGALVVSFKDRYVAEKLVHGPSDIPSVGKVEFAWVANAPASSAQPPGAAASAPKTSEDVSMTDSNATAAPVPEKEPAHEVDYDVAEMDDSWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D418</accession>
    <name>D4D418_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024064.1">
        <property type="nucleotide sequence ID" value="XM_003024018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D418"/>
    <dbReference type="GeneID" id="9582757"/>
    <dbReference type="KEGG" id="tve:TRV_01831"/>
    <dbReference type="HOGENOM" id="CLU_2251975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="12595" checksum="A49F12EBF8E87A2A" modified="2010-05-18" version="1">MALQESLFSPQRVYLLLIVPFLQDPVQLWQGGKQAGNCISKIYTGEYPSVWINKGTDSQAAGPDKKREIGFFLALSLAVCSRLVAFSGFRAKQTDAARRRKRNDFEVAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A2</accession>
    <name>D4D4A2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023975.1">
        <property type="nucleotide sequence ID" value="XM_003023929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A2"/>
    <dbReference type="GeneID" id="9582668"/>
    <dbReference type="KEGG" id="tve:TRV_01917"/>
    <dbReference type="HOGENOM" id="CLU_022876_0_1_1"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32758" checksum="53B614CA5DD7A011" modified="2010-05-18" version="1">MLTRGGKTTGFYHSDKPLVQQALARSLSYTLVPSLPEQMVLPFLRAFWITMSRDFHSLDRLRLDKYLFLIRCYVGVSFEYYLKRGGKSKRQPGNNSTENQKAKNKRKRERDEADSEVNGGSTSRRKTSSTSAVPVREGDEWAELEAYLDMLEDGPLSPLIFDPNPSKQLSNQEDENGALIKVPKGPDGIRYHLMDIWLDELEKCATEPDESSAGDDGESRATKLKECVPMELLLRPIERLQSESPNKTVRSRAKETLTDERLISWGVREPEKPDEGSDEEEEWGGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4S9</accession>
    <name>D4D4S9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000112">
        <property type="protein sequence ID" value="EFE43135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023753.1">
        <property type="nucleotide sequence ID" value="XM_003023707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4S9"/>
    <dbReference type="GeneID" id="9582301"/>
    <dbReference type="KEGG" id="tve:TRV_02096"/>
    <dbReference type="HOGENOM" id="CLU_1679238_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="157" mass="18068" checksum="46D21BA7CBF409A7" modified="2010-05-18" version="1">MEEELLLLALLVGQPSHLLLQLQRRPDLFRWFFFFFFFFYYYYFFLSIPRLPLRLHLRPRPRRLRRVSKANNNNNKKKKKKKKKKGDQAVIPIRPLASAPGSRRAKAKATKAFPGLVVRRSSPSVACVSSSSSSSSSSSSSLCKLPPKNLMLSTRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D519</accession>
    <name>D4D519_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023680.1">
        <property type="nucleotide sequence ID" value="XM_003023634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D519"/>
    <dbReference type="GeneID" id="9582227"/>
    <dbReference type="KEGG" id="tve:TRV_02188"/>
    <dbReference type="HOGENOM" id="CLU_053752_0_0_1"/>
    <dbReference type="OrthoDB" id="4172792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="422" mass="46285" checksum="98D987B7FD4D9808" modified="2010-05-18" version="1">MARIQAPAALNHAGEREEIPGPSKDGIYKTLMVISTAVSELSRAVQQMREQLNGLSSACTGNPGLPKSNNPVDQFEIFAIAMKEVQSKSSRIEQLEQENRVLRDKLGDCEKAGERSEGFSQIIPISRNEIGERFVPSDAPNLNGKRSLVTLPRGLRTHEDNSTIATGVIPASTDVTNPEVYPSPNSNQRIGIDGPDLEIEEIPESSNAQVNGDDLSQEDSPAMSGATLSKLPAEKPRTRQNPVRRRRGLRTEQVLEQVTGNETRPTRPPLVAQNEHSKKAENSASLRKEQTTSSGDENSTKTGDRKPGGLAHTETPKGSETFTPNIARDKRLRPRRQLMKRGRGRPKVIASQQPQVEIVTSTSPPPTTGRPDVDDYSLNGLGNREDASSAKNEEDEKRRKAEIAARELLVQAAMQREEAYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5A8</accession>
    <name>D4D5A8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023531.1">
        <property type="nucleotide sequence ID" value="XM_003023485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5A8"/>
    <dbReference type="GeneID" id="9577003"/>
    <dbReference type="KEGG" id="tve:TRV_02278"/>
    <dbReference type="HOGENOM" id="CLU_1011824_0_0_1"/>
    <dbReference type="OrthoDB" id="3914029at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="252" mass="27575" checksum="CD3E01D2098F76F6" modified="2010-05-18" version="1">MDEAVPSYEESEASFAQDKKQPLHASPPPSLLPQHLAETRTQRIQSILTAYVDPLLFSQGSDGLYKTTFVLVPSSVASLQDAVGNAAAATPQEPQVMGFPSDEVVKLVRLQGPGHTMEFWRQPAVVAELDSALRARLAASGHRIYEQPTDTPTVSEHEPEQQSQQQQQPAPAPKGKLRRSFWRLAGGSDDTINDQKLGWRAEEPADEARKIPTGLVKVTIAWKEVALRISNEMGLYDTQRGPALCLTVEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D681</accession>
    <name>D4D681_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter Ccc1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023270.1">
        <property type="nucleotide sequence ID" value="XM_003023224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D681"/>
    <dbReference type="GeneID" id="9583278"/>
    <dbReference type="KEGG" id="tve:TRV_02604"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_2_1"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="29763" checksum="2C667CF91B398669" modified="2010-05-18" version="1">MLGGRHSHWSPQDLEEQAFSPYGTFPPSPTESTETSSSISSTRPRVNPRIVSDAILGLSDGLTVPFALSAGLSALGNSRVVVVGGLAELVAGAISMGLGGYVGSRSEVESYEATVRETKHLVKASPMETMNIIHQVFAPYNLPEEPVARMSHILYNSPEKLLDFLLTFYHKEAKPGCHQAWISAITLALGYFIGGFIPLIPYFMVDQVLVALYYSIGIMIFTLLVFGYVKTCVVRGWTGKENIVAGIKGGLQMVVVGGLAAGASIALARAINPTGGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6B0</accession>
    <name>D4D6B0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000136">
        <property type="protein sequence ID" value="EFE42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023231.1">
        <property type="nucleotide sequence ID" value="XM_003023185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6B0"/>
    <dbReference type="GeneID" id="9583253"/>
    <dbReference type="KEGG" id="tve:TRV_02635"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30455" checksum="9784E8C81663743D" modified="2010-05-18" version="1">MLPTPSTSHVAFDTIYEPAEDSYLFLDTLSDIDESIWLSERFSPGASDQGSGPLPTSTTSPSPVVVEVGTGSGVILGFLAANCKAILGRSDILTIGTDVNRKACSATRQTVKVAMSDNYSVENFRATPANKEGTNAKVPKPAQPLAVITGDLCSPLRAGMVDILLFNPPYVPTPELPHLPSSLEATSSASGMSKFEIESYFLSLTYAGGEHGMEITDRLLDSIPHVLNPERGVAYVLLCAQNKPQEVMDRINGWGNGWKTEIAGRSGTKAGWERLVIVRIWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6M6</accession>
    <name>D4D6M6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_02753</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000144">
        <property type="protein sequence ID" value="EFE42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023110.1">
        <property type="nucleotide sequence ID" value="XM_003023064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583130"/>
    <dbReference type="KEGG" id="tve:TRV_02753"/>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="245"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1495"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1506"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1566"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1602"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1688"/>
            <end position="1744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1744" mass="192572" checksum="03FEDF3D68BB8BC2" modified="2010-05-18" version="1">MSSVRFPYSKAQLRTIKEIQFGLLSPEEIKRMSVCHVEYPETMDDQRQRPREKGLNDPRLGTIDRNWRCATCEEGINDCPGHFGHIELSTPVFHIGFLTKIKKLLETVCHNCGKIKANASDQKYLDALRFRDPKKRFDAIWRLSKDILICEADPPEEDDPFAKESSKPVQGHGGCGNVQPQVRKEGITLMGTWKPSKMRDMMDDNEIQQPEKKQITPQMALTIFRNISEEDVRLMGLSNDYARPEWMIITVLPVPPPPVRPSVLVGGSGTGQRGEDDLTYKLAEIIRANQNVTRCEQEGSPEHVVREFESLLQYHVATYMDNDIAGIPQAMQKSNRPVKAIRGRLKGKEGRLRQNLMGKRVDFSARTVITGDPNLSLDEVGVPISIAQTLTYPEVVTPYNIHRLGQLVDNGPDVHPGARYVIRSSGERIDLRHHKGGGGRNFLQWGWKVERHLMDGDFILFNRQPSLHKESMMSHRVRVMPYSTFRLNLSVTTPYNADFDGDEMNLHVPQSEEARAELNQLCLVPLNIVSPQRNGPLMGIVQDTLCGIYKICRRDVFLTKEQVMNVLLWVPDWDGVLPQPAILKPRPRWSGKQMISMVLPSGLNLLRIDKDKSPISEKFSPLADGGVLVHGGELMYGMFSKKTVGASGGGVVHTIFNEYGPDAAMSFFNGAQAVVNYWLLHNGFSIGIGDTIPDLETIQKIENAVRVRKEEVDSITASATENTLEALPGMNVRETFESKVSRALNNARDEAGTATEKSLKDSNNAVQMARSGSKGSTINISQMTAVVGQQSVEGKRIPFGFKYRTLPHFTKDDYSPESRGFVENSYLRGLTPTEFFFHAMAGREGLIDTAVKTAETGYIQRKLVKALEEVMVKYDGTVRNSLGDIVQFLYGEDGLDGQCIENQRVDVIKCSDEQFRNRFRVDLMDPERLLSPDILEQATEIAGDIEVQKHLDEEWEQLLKDRAFLRTVVKEDDEMMQLPINIQRILESAKTTFRIRDGTISDLHPAEVVPQVRQLLDRLLVVRGDDALSREAQESATLLFKAQLRSRLAFRRLVVEYSLNKLAFQHVLGAIESRFGKAAANPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNVATNIKTPSMTVYQAPECRMNKESAKQLRSIVEHTSLRSVTESTEIYYDPNIQSTVIENDIDMVESYFIIPEDVADDSSRQSKWLLRIILSRPKLLDKGLTVQDVATKIKEAYPQDIAVIFSDNNADEQVVRIRQIQDPKQDEDDDDTEYDVTLKKLESHLLDTLTLRGVPGIDRAFINEKSRTRVLEDGSLHQSASDPECKEWVLETSGSALADVLAIPGIDASRTYSNQFVEILEVFGIEATRTALLRELTQVLAFDGSYVNHRHLALLVDVMTSRGFLMAVTRHGINRADTGALMRCSFEETVEILLDAAAFAELDDCRGVSENLILGQMAPAGTGEFDVYLDQSMLMGVVSNNAGLGAMGEEPKGMLSDGAATQYDSGSPMQENMYISSPDPDSQFSPVRQAGSENAVGFADYQPPSYGGFSPHEPRSPGGGYSPSSPFNTSPTSPAYSPSSGYSPTSPGMSITSPRFISSPAFSPASPSFAPTSPAYSPTSPGYGQAQSPTSPSYSPTSPGFSPTSPSYSPTSPSFSPASPVFSPTSPSYSPTSPALGGTGRHLSPTSPTSPKYTPTSPGWSPTSPEAYSPTSPNFSGSPTSPGGPTSPGYSPTSPTFNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6R0</accession>
    <name>D4D6R0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023097.1">
        <property type="nucleotide sequence ID" value="XM_003023051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6R0"/>
    <dbReference type="GeneID" id="9583117"/>
    <dbReference type="KEGG" id="tve:TRV_02787"/>
    <dbReference type="HOGENOM" id="CLU_3191637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="46" mass="4964" checksum="D19DC3C89A876361" modified="2010-05-18" version="1">MQLGALQCEGEKAEEEEKNPTEESLLDKTGWLSATAISLAILSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6V0</accession>
    <name>D4D6V0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023006.1">
        <property type="nucleotide sequence ID" value="XM_003022960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583026"/>
    <dbReference type="KEGG" id="tve:TRV_02827"/>
    <dbReference type="HOGENOM" id="CLU_001331_1_0_1"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="12">
        <location>
            <begin position="525"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="790"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1380" mass="151455" checksum="4CFF7DE3915B02B0" modified="2010-05-18" version="1">MLSDGPLASRHDEIAEPLARLKEAAFLDANDLSKGRLFDENTLPERPRLETVLAECESKYGPSRPDELDRPRVPPPQSAAGITSHEQPTQGGLAAGNDQPQLTVSSAGVQTTEPPEPVPPVASFQHQPNGIDTSPPQHAAEAPAKTASSPDTAVQATTQATAHPLSPPETNRTSSFNDRLGVAPIIVPPKAAEAASSPMSTGPSSSHTSATERSPASSSTESVASIAESPSMGKHSTDEPPSNVQSQPMSTAVPSTPDEQLQLEAAMSIRNSTTPKQPITTQDKDGDQHMTEAPTELKEPQLKREPTESVTNSRPSSSSGPQVVSDGKTATKPVESQRQPAEQQHPRPERMTTRVASGAIRHKSVSEILGESPKPSATPETEQHSRDSRRSSVFDKQAGTSHTSPASPSKLRLSERPDKERSRLSTVVFPKTSSQEKGKAMQLASGRDEETRKSPNEEQDYLYTLFQAKAHYPPRTMSLNTLLSTAHKTLSTSNHFLEYHEQMDCRTLKRIYQLQHSNRWALRQLQRSPEPPRQATHWDIMLDHVKWMRMDFREERKWKLTAAKRCAEWCADYVASDEDCRRSLRVPANIPPPPAAEAPESDKLIDGHPDEVLPNNHPTPDLIHSADDDSVSDGFNDEHPDFDDGNVPAAIFSSGSDEFTFRMERTIASEKILGELPLYCPVQIAPETNKPAFKIQPDDVWKTQLLPVSKYAQGTIQFKEDGPPRKRSRYDYEQDTYYDGEEENGYRSLLPEQVDVALFSPEYKALRDRIHPGNAFRPPTEYIMPPLGFYESRQSSHWTLAEDDELRKLVQEYSFNWSLIASCLAPRSSFVSTSERRTPWECFERWISLEGLPPDMAKTPYFRTYNARLEAAQRTIMNAQQQAVQQQQQQQQQNGGQVNPSAQALIRRRTAQPLRVERKRSSRHLALLAGMRKLSQKRETNLQKQQHATQLASMRKVNEATQPHPPISTPQEFSQLKHERELKFLEKQEQYRQQMIAHQRAAMAQRAAQLNPSGQFNGMPVRPPAAVPNGAGGVQVPTANGLANGIPNGVAVSQSRPHPGMAAMPNGLPATGPIPVPSGMSMKMMPQQGLQQPINGRPGLPIQTSPDNSRIIREANRLQEQQRLLQSRQQQHQFHGGQQGFAPQQGPHSSPNMNATPATTSSNPALMAAFQAATNGGSPSFAASSLTPGVMPASSPRMNHPSTSLNNAPSLPNVNNIQASLQRLHPTMSQEQVSKFATERLQQYQQQRLSQAALNAAAGNLGVGNLPSNYQAGNSGQQISQQGTVNGVTPVPLQNQTQGYINRLGASQPGGQQNRPGVGIASPAMTNMLMHQSRSATPQSQRPSSQGGPQQQQQPPQQQQTQPPPPGKSPRPAQAQTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6X6</accession>
    <name>D4D6X6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_02854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023032.1">
        <property type="nucleotide sequence ID" value="XM_003022986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6X6"/>
    <dbReference type="GeneID" id="9583052"/>
    <dbReference type="KEGG" id="tve:TRV_02854"/>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="16215" checksum="A5BBCFE4C1CBE732" modified="2010-05-18" version="1">MNLVLADTEEFRRVKKKSGKGGQAAPGSSSTTPLVEAEEKRTLGLTIVRGTHVVSCSVDGPPPAEPAARLGTTAAGLAGGSATLAAGPGISKPAGRGLPVGLGGPAAGVGGPPPPAGFGAFPPPAGFPGGPPPGFGGRGGPPGGPPGGFQPPPGFQPPGQGRGFPPGMGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D710</accession>
    <name>D4D710_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022983.1">
        <property type="nucleotide sequence ID" value="XM_003022937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D710"/>
    <dbReference type="GeneID" id="9583003"/>
    <dbReference type="KEGG" id="tve:TRV_02889"/>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="589" mass="62386" checksum="3FD62A4E898AF039" modified="2010-05-18" version="1">MTQLPAPAQNPHTTTTTATTTANAFAIEEDSRATASDCSSEQLAIPISDTASTMATPQDQASAPAPPAAATQPGAQSTPPVDTAPSKTPKPASAQKQAKEKPAAPDGTEKLSGAELKKRAKAEKAARRAKEKQERPRPTSEDQEDDTAPYAASTGSTVSSATSTPQGPLTPKKAASVKSDTSKSSSKSSITRHGSVHTLPTPPAPVESTSSKKKRREVVDEKVVAVFGHLPWYTRRTGIAGANKDVHPAVLSLGMQIKDYVVVQSYITPPGTSLTRHLTTHLGHQIAFLASCRPLAISQGNAIRALKLIVSSIDPSVPEPDAKQEIYDFIDNFIREKITVAGQVIANSAAGKIDDGDVILCFSGSSVVQRTLLTAHKQGKKFRVSIIDTRPLFEGRNLAQTLAKAGLRVQYSLINGISQAVKDATKVFLGAHAMTSNGGLFSRVGTALVAMSAKEKSGGMNISVIVCCETIKFTDRVALDSIVVNEIAEADELVAAEPCTTLTDLPPPVTNVKPETSKGSSSSAIEIPAHLKNPKLPLENWREMPNLQLLNIMHDLTPAEYVDMVVTEMGSLPPSAVPVVHRMSTENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D713</accession>
    <name>D4D713_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022986.1">
        <property type="nucleotide sequence ID" value="XM_003022940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D713"/>
    <dbReference type="GeneID" id="9583006"/>
    <dbReference type="KEGG" id="tve:TRV_02892"/>
    <dbReference type="HOGENOM" id="CLU_061288_5_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="190" mass="20778" checksum="ADA1E1884205FCAE" modified="2010-05-18" version="1">MKHAASSAGPKEKKPRLSKLAKENNITSEEEAEIREAFHLFAVTDNEEYASEKEGVIATRDLLICLGCHRALGLAPTDNAELRSIISAVDPAGEGFVIYEHFLSVAALKLHNRSEDSVSAEVEHAYSLFTHGTEGPILMSHLRAVAKSLKEDVSEELMKDMIREANGGDGIQSGVNIEQFKDVMKRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7K1</accession>
    <name>D4D7K1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein Pth11-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022787.1">
        <property type="nucleotide sequence ID" value="XM_003022741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7K1"/>
    <dbReference type="GeneID" id="9581522"/>
    <dbReference type="KEGG" id="tve:TRV_03083"/>
    <dbReference type="HOGENOM" id="CLU_028200_2_1_1"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="80"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="46009" checksum="5262800F6E005E3F" modified="2010-05-18" version="1">MSSPKASSNQMPIYAPGLLFLADPQRPSRQHYRAYILLRYIPAENICLDILPTPLSKAKKTQNKDGVWCYSQKNRPDAAKKSFGVDDAVIVSSALYRYLPSIYLTLANIESFRYAGSSTVNFAGRPFYMAGITGFKVALCIAYLRIIRHSSEKSYRHVVWAIMIFTILSHVAGTLVLFFQCSPVHKSWRPLTPGKCLPNAAVFYSLAGVSIFCDLIVFLTPIPLWLKVRISTPRKLGLMAVFLLGLFTTACSIMRVVQIEIIAKDGNSTMLILWGTIELNVGIAITCLPTLIPLITFIQGRTSKSGPMQYPHSTSDGRSAGTSVKLKSVGLHSSTMRSQTIPTGNNTLVKSGSFSSLEAILPVDSQGRPIQREDMESSNGNGSQSNVHLSNPGHITKTVQVEITRTDNRPGPEQSWLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7X4</accession>
    <name>NPIIF_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Neutral protease 2 homolog TRV_03208</fullName>
            <ecNumber>3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Deuterolysin TRV_03208</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TRV_03208</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39"/>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022687.1">
        <property type="nucleotide sequence ID" value="XM_003022641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7X4"/>
    <dbReference type="SMR" id="D4D7X4"/>
    <dbReference type="GeneID" id="9581346"/>
    <dbReference type="KEGG" id="tve:TRV_03208"/>
    <dbReference type="HOGENOM" id="CLU_039313_1_0_1"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407146" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407147" description="Neutral protease 2 homolog TRV_03208">
        <location>
            <begin position="188"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="379" mass="42130" checksum="4E1AB840CF6CD71F" modified="2010-05-18" version="1" precursor="true">MKFFTALAAVGALLAPALALPTPASEEASHNQTLSVRLVPAGHTMVRAIVTNNGERPLHLLSFNTILDEDPTSKVEVFHESGDEAEFLGMLPRYDLSDLTEDLFTRLAPKDSVEHLFDIATVHDLKWDGKYTLAARGAIPVAEDGGTTIIDHVYYESNELDMEIDARKAAMVPRAFDDYFSKSLDKRRPLDICNPRKERDLRAALEGAQQVAKEAAAAAQNNTEKVFEFFRARDPGTRKEVSQHLSSISRAATKDGSSVTWFCSDGPGRCGPRTIAYTFPAKNEVHPCPLFWQMPHVNNKCHRQDRVGTVIHEGAHNPSVVTPYCKDLGYGYNRATGLTSQRAKRNADNYALFAMARQLVFCLLHLFVALPFIYIFASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D830</accession>
    <name>D4D830_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022608.1">
        <property type="nucleotide sequence ID" value="XM_003022562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D830"/>
    <dbReference type="GeneID" id="9581267"/>
    <dbReference type="KEGG" id="tve:TRV_03265"/>
    <dbReference type="HOGENOM" id="CLU_1670654_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="158" mass="18544" checksum="6AC8C26BC65D4E4F" modified="2010-05-18" version="1">MPLGGRVDNKAPLLRPQTRRLDEKQAERKKRLFNGAQAESLSQRIISSSSTSDCHLRPTSQPSRTASHEQATKEALEGDKRVKFPRPPQKTQDAGRPQKKRQEEEDKKKTRRTRRTRRARSQKPEETQKKQRRIETLSSLCFFPRWLLCFFCSFSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D841</accession>
    <name>D4D841_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022619.1">
        <property type="nucleotide sequence ID" value="XM_003022573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D841"/>
    <dbReference type="GeneID" id="9581278"/>
    <dbReference type="KEGG" id="tve:TRV_03276"/>
    <dbReference type="HOGENOM" id="CLU_048020_0_0_1"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="51400" checksum="2F984F5A6AAD51B0" modified="2010-05-18" version="1">MNSQNSSSAPSGSEGAALPWILEHLLAYPGSYEIPLRTMYTLNSSPRMTDLSSVSPTLNGSAFSKANTAPSPTGSAPSSRHEKHGSADSSMSDTAARFKAQMMAQIAQLPSQPASLPPSFITSFVRRSFPPVLEEVDFPQALTALDYLRDLENRRKREVVNAFDRLGLTGTESERQELSRRYPGVLAWLNKIQENERNVIALYTQVYLRIRYWALVNEMLLTPFNRYNCIALLNTLFPPLDSRPPTPHLNGKLLLDHRMRFYDYICSFEKKGVQVLKHVIEQDKRPEDKTGWPVARCMIDKYLDLANSMINECSEVTGCQHFAESSEGQRKGRKVDSGISFTSSERPSTSGSSSSSSKNITKPSTPPSQSQQLKGTNGSTLEKIAREIKKLKSRGDLRDAAKEPKRPNTVKKIKSSGLLRETMRGLSLSDEPTFDPDKFKQQRKQWEAKNAHKLRQAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K3</accession>
    <name>D4D8K3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000179">
        <property type="protein sequence ID" value="EFE41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022437.1">
        <property type="nucleotide sequence ID" value="XM_003022391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K3"/>
    <dbReference type="GeneID" id="9580984"/>
    <dbReference type="KEGG" id="tve:TRV_03440"/>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25113" checksum="E67EE942868CE8A8" modified="2010-05-18" version="1">MAPKKENAKKAAGNARLILNLLFKKAEAAAAKQAAADQKKAAEEDKEWQKGAKSSAKKESAEEKKAEAARKKAEREALLAEEEKSLPSKPKGNAKTAQKKSRGTLDLGQLDVDPTSSKKGATLNASGIDYALDALSLGSKDALKIDRHPERRYKAAYAAYEERRLPEIEQEQPGLRRQQRIALIKKEFEKSEENPFNQVNVAFDATKEEVAAAREAEKAKIESRLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D915</accession>
    <name>D4D915_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022281.1">
        <property type="nucleotide sequence ID" value="XM_003022235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D915"/>
    <dbReference type="GeneID" id="9576884"/>
    <dbReference type="KEGG" id="tve:TRV_03605"/>
    <dbReference type="HOGENOM" id="CLU_2607748_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="9125" checksum="12E74D7F749C01C2" modified="2010-05-18" version="1">MMTSQEVRRIKKERKEERKKEKKEGRPISTGRKKDAGWAAGVEMDMRVAGKKGVWGVDRAVRVVRWGLVSLVSEKEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M9</accession>
    <name>D4D9M9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022081.1">
        <property type="nucleotide sequence ID" value="XM_003022035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M9"/>
    <dbReference type="GeneID" id="9578965"/>
    <dbReference type="KEGG" id="tve:TRV_03822"/>
    <dbReference type="HOGENOM" id="CLU_062454_2_0_1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="253" mass="28288" checksum="3FDF26A1A6B14A7D" modified="2010-05-18" version="1">MSSVTGPTRSLRSNTNLPAEEPSAQKLFNNIRNEILNTNHSTDLTFQNISPSAGFQIATSFSEDPEIERALPRISYNPLTKVLTARVMPTTVQDCHQEWLSNELLDMVMAGFLTVAEREELRLRVGTSMMHLFSFYFTFLSFLKFDLIDILLLALAGFAAPYTSAVKEPDACILPDSLPLPTVAVESCWSESWPRLEADRDLWLVGGTAVELVLLIRWTKISNGRVKGDLHVHGRDLAGNVVLLRTEVCDCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Q3</accession>
    <name>D4D9Q3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022029.1">
        <property type="nucleotide sequence ID" value="XM_003021983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Q3"/>
    <dbReference type="GeneID" id="9578913"/>
    <dbReference type="KEGG" id="tve:TRV_03846"/>
    <dbReference type="HOGENOM" id="CLU_025799_1_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="532" mass="57047" checksum="92BA868FE60D9319" modified="2010-05-18" version="1">MGSNTEFAAMPPPPTAPYTTDTNPGMINETQNTQILDIPAESVTFSHEGLDNNVSIPSMTYASSSSELSSVSSISTHEGHNSTMVASGEGPNIKAKEFNISAAKPDLPLKYSNPLTGWRNIAPAPPSPATALSPSTATIAPGATIGAISSTVGSTVPIVPTPKASPSKPTSRRRRTTGGAKPRNPRKSGRYGDRNDDGGVIKAEDTDSDESSDAQLTTTQTKSGRQIHRPTMFTPEQVQKKSVSPDTNHQQPPRKRRRVYRKGKEVNVVCLRCDRGHSPRCNAIVFCDDCNAPWHQFCHDPPIGDDVISVKNKEWFCRECRPIDTPLGLTLKPNGQIREQNGLRTSISPSMQTSGPQTPTLLAGSQLSRAEKQRYLSSLSHAALVNLLVDISDSRPDIPIFPANLNELNTASFSSSTSTISSSIVSNGLAGGSQQYKILGQATTSTPPSLKRPSESVPASTRNGIGENSDEEEVEEHRLYPKPGNGFRLPPDSEDIDMLLEDPSSTTFSHALHGPAKAMVETNHMQIVGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA88</accession>
    <name>D4DA88_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021857.1">
        <property type="nucleotide sequence ID" value="XM_003021811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA88"/>
    <dbReference type="GeneID" id="9578739"/>
    <dbReference type="KEGG" id="tve:TRV_04034"/>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="95"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="304" mass="33843" checksum="6B25C4DF8EE13571" modified="2010-05-18" version="1">MLTETQRRQARERRDYLYRKALQLKDASIAERRAKLKQSLASGKPLDPSIANDRRLREDFKYDESLPVGDPKAKGAAEEIDIDDEYGVTSGLVDPRPLVTTSRDPSSRLSTFAKEIRLLMPTSIRLNRGTLVLNDLVASASASALSDMVILHEHRGTPTAITISHLPHGPTASFSLHNVVLRADIPNAARGTVSESYPHLIFEGFTTKLGKRVVQILSHLFPPREAGKVGSRVVTFKNIEDSIEVRHHVFVKTGYQDVELAEVGPRMTMRLFEIKGGTLEKGAGGDVEWALTQYTRTSKKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAK4</accession>
    <name>D4DAK4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04151</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000210">
        <property type="protein sequence ID" value="EFE41116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021734.1">
        <property type="nucleotide sequence ID" value="XM_003021688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAK4"/>
    <dbReference type="GeneID" id="9576821"/>
    <dbReference type="KEGG" id="tve:TRV_04151"/>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="19">
        <location>
            <begin position="330"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="493"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE41116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="594" mass="64952" checksum="B4318CAEB0E5F884" modified="2010-05-18" version="1">MYVKLFKLITTQVRTLNWQQSEQKLTWVKITHSEWASEDAFSASVGAGAARQKTGGSHASFKRLPFNFCSLSLQPFSHPVCTSDGIIFDLTHILPWIKKNGINPVNGAPMKNSDLIKLHFAKNESGEYVDPVTYKVFTDNTHIVALGNTGNVFAWDTVQKLNIKPKMWRDLVNDEEFGRKDIITLQDPHNVNARDLNTFKYLNDGENNTTSGNDGQGINLNAMGSSAKILRAKEAVAKARAEREQKATSADALSQRQKENLSVKKSLTTSQSGKAVPFNAARHTTGLAAASFTSTGLTPHTAADLSIMTDEEYMLKCGRVKIKGYARIVTNLGDLNIELHTEHAPKAVWNFIQLAKKGYYKGVTFHRNIKGFMIQGGDPTGTGKGGESIWGKSFADEVIGPFKHDSRGTLSMANKGKDTNSSQFFFAYRAVPHLNGKHTIFGHLIDDPSPSSPTLDAMEVAPVDSSTNRPTPAITMLDVVVFVDPFEEFLNKKRKEENAQQSVSGASSDTKDKGDDDQVTWTGKRLRGYGSNESGSASGNVSGVGKYLKASAAASSGNEDEIVGFVDEDELESEHARKKIKNAGRGGFGNFDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS9</accession>
    <name>D4DAS9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021647.1">
        <property type="nucleotide sequence ID" value="XM_003021601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS9"/>
    <dbReference type="GeneID" id="9578608"/>
    <dbReference type="KEGG" id="tve:TRV_04227"/>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="456" mass="52376" checksum="C0837744439A7F1F" modified="2010-05-18" version="1">MEMAYDDSAWERSDTIFDSFKKKASSPDVLRAVTEFMAAKYPVSQPNDRARIIGVGAFNFCYRMEFGNGTSSLLRFASPGRSMFPEEKTQAEVAIMLYLKDNTDIPIPTIFDWGMEGPCDMGPYILMEFVSSASNLTAKLRKPGYAREDRPVLDPDINESKLELLYGQMADITLQLSRCSFNKIGCLAAGPGGWAVTKRPLTMNMNELVQLGGYPKDLLPSSPFTSASDYLKNLAETQYTHLSTQRNDAICSEEDCRRKYTIRKIVLKLAEQSKLMGQDTIDHNKYRLFCDDLRPTNVLIDENSKVVAVIDWEFTYTAPSEFTYSPPWWLLLETPEDWPSGILDWAVTYDSRLKVFLRAMTRQEDIAIRDGRLSDRERLSERMYNNWSTGAFWINYGLRKSWALDIVWPFIDRAIFGGEQPHEQRIALLENRIQLTDDERKEMDAFVQRKLRDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAW4</accession>
    <name>D4DAW4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021632.1">
        <property type="nucleotide sequence ID" value="XM_003021586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAW4"/>
    <dbReference type="GeneID" id="9578593"/>
    <dbReference type="KEGG" id="tve:TRV_04262"/>
    <dbReference type="HOGENOM" id="CLU_018004_4_0_1"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.10:FF:000002">
        <property type="entry name" value="mRNA capping nucleoside-triphosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="596"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="880" mass="96321" checksum="20034AADD2231FF0" modified="2010-05-18" version="1">MDLRTIINTDSAVGAARGPQLHQQPPPSQQQQQHHQQQQQQQQQQRTQRPLSIHSLGPDEPPLRSGSVHDEHPPQHHEYGGGPAGGRPSQPLQPPLQSPKRISAPYMGSTAQSPYQQPPLASILTGREPGERASSVLPVPREPYSASSLPPPSAASLSSPFTPQPTSAGTQHSSYFSQQRSQSAHSAASPSSVRSLSYPSGREPSGHPYSPSQQHQQQPQLQQQQQQHQAFHHQQPPPQQQQQQQHYQQQQQQQRSQPGTPLAPPGSSYRRPSPHPVRPPSSGHDAPLSARLGSPWGSQDASSGGQRDGVSPTVHTPISRHNSVATDSYPRQFSMEREKEQHLDSVSPKTIVSQQGAAPYGDISASNAINRDNAIGSNHSTLNQSVQTPHKDPELAQQTTHQPGLEHQTLPPTTARPSYPPSTPQTASISNITNSATTASGSPTGRRPVQEASPTLQHHPFPPKPLHQPRSSISAAPGPSSAVERVPMCPPRKKRKRYTQPPIFACKAPRTSGTPPPIPPKGSQALAQPPPSSLFPGKRPLPKRESLDRNLTSDSLPPRPSRDADMAVNGNAVKESAADNPLGPWEPTITNVIPSEELTKLICDFLFQQVVMRKDIGAGPAGGMAVGSGAILEVEAKLGRLIDKSRGERLRLPILSETVISKDDPNLRLAFESSMSQAQHRAMNNFLNEAVKTSISQGTTRIPLAYAHKRERDTFYDISANDLPPIVQHHLHPRHKPRVRVTTDVRTGAVIARIVKCRIADLDVYSPRTCLDWRISVNLEMNYDGDLTKLQQTSDWKRSGDRNKDRMSYRHLAYQIDLTQVGTTDSTPADFEHELEIEISSAEIRRQGDLALSGDMNNQYEDLIKGFVDNIRVLARAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAY5</accession>
    <name>D4DAY5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021610.1">
        <property type="nucleotide sequence ID" value="XM_003021564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAY5"/>
    <dbReference type="GeneID" id="9578571"/>
    <dbReference type="KEGG" id="tve:TRV_04283"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="55553" checksum="2C20C0C5ACB88F55" modified="2010-05-18" version="1">MSTADASTDTVPIEAGPIEETKVADPEVVDWDGPEDPENPHNWPSRKRWAHVVVIAIICLVMNIAPTMCAPSINLLVAEFNIRSFVVSTFAVTLYLLGLSVGPMFISPLSEVYGRLPVYHISNVVFVAFVIGNALSKNIGQFLAFRFLSGCAGGTPMALGGGSIADVTPIQRRAIAMALFSLGPLTGPVLGPVIGGFIAAGKGWRWIFWILAIIGAAATITGFVILRETHPGIILERKATRLRESTGNPHLRSKLARSQSPRQLLAAALIRPTRLLIRSPILLIISLYVALVFGLMYLLFTTFTDVFEGEYGFTTSTSGLVYLGLGVALVICMLLFGALNERVQAACLKADGATQPRPEYRLVLMIFFSPLVGVGLFIYGWTVQYRVHWIVPIIGTMVMGFGAFFVLVSFTSAINPSRSLSTLTKSHQMPAQLYLVDLFGSEAAASALGANNLMRYLSSTFLPLAGPKMYKTLHYGWGNTLLGFLALAFVPAPILFYKYGEWLRAKNVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB22</accession>
    <name>D4DB22_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021579.1">
        <property type="nucleotide sequence ID" value="XM_003021533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB22"/>
    <dbReference type="GeneID" id="9578540"/>
    <dbReference type="KEGG" id="tve:TRV_04321"/>
    <dbReference type="HOGENOM" id="CLU_2014706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="150" mass="16857" checksum="AA79A7BF3B94E732" modified="2010-05-18" version="1">MQRLCLVKRERNSRFWKLKLVLIRWALSLLLWIIGITCQRSSYNYLADPETGHGLFLVLQSADVTPLAHVLDSGYDFDALPVAAAAAAVEYPVDRSFDYFAEPVMAQGCLVQRKGLKPSMYYMQDTGKGELPPQTVRDLALKVALPLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB66</accession>
    <name>D4DB66_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021518.1">
        <property type="nucleotide sequence ID" value="XM_003021472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB66"/>
    <dbReference type="GeneID" id="9578479"/>
    <dbReference type="KEGG" id="tve:TRV_04365"/>
    <dbReference type="HOGENOM" id="CLU_044725_1_0_1"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055453" evidence="2">
        <location>
            <begin position="44"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="382" mass="39827" checksum="1974C9F07DA1D2B1" modified="2010-05-18" version="1">MQRRSSCVTQQRRRCSSILGHMFDISHLLVVFVLFVCFSPVQAVAGNSLDDRDFTSNNSSAANGVIPAKRDHGEGEYPFLVRKMSDDPGQKFFGHYWSLDSMVSSGEDAERPRDKTPLNARSPLLLHSYPLPVAGRSVLGKRGFECPAGSAPCQLISCPKGYTTCPANLGGGCCTPGYTCVAEGCLLVTTTTVIITLPSSTITTISTISHTTVAPPPPPPPSTTETAPTVLPPGRPTSNPSTSTASIPDLCPIGFYACSAVYGGGCCQTGRNCETTSCPVTASLTTVESNGVTVVIPVNTTPNSASATATRRCADGWMSCPPNDGGGCCPNGYQCGEVSCTASATNIGTAVIGKAQPGNSGSRLSPTIYMWVIGLIICVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBF6</accession>
    <name>D4DBF6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021382.1">
        <property type="nucleotide sequence ID" value="XM_003021336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBF6"/>
    <dbReference type="GeneID" id="9578396"/>
    <dbReference type="KEGG" id="tve:TRV_04456"/>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="257"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="476" mass="54865" checksum="BCCCBBF54E55C0D7" modified="2010-05-18" version="1">MAQDNRGRLPPNLQDESDVEEEALVNDYREQVHFDDGMSELDRTTSLGATSQTQDLQAQLAAAATPLEYQATLETKFASYDNYCSLFHYILNSDGPVDLEVPSYFWAWDVIDEFIYQFESFCRYRNRVARTGSNEEEAQLLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRNEDPMAVAGEYGSRPLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKGRDGYDAIAKKNDQMYALIAICVAFHPTRLDDTIHSAIREKYGDQFNRLQRGRPDALPIFEELFRSACPKFISPTPPDFDNPSLNVDPVDHQTAIFMDEVKNTLFNPTVKSYLKLYTTMDLKKLAGFLEVDAEQLRAWLLINKQRSRQIRWVDGGLLEGEAVNAGDLDYAIEGNLIHISEVKAGRRLVDWYLRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBY7</accession>
    <name>D4DBY7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021207.1">
        <property type="nucleotide sequence ID" value="XM_003021161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBY7"/>
    <dbReference type="GeneID" id="9578052"/>
    <dbReference type="KEGG" id="tve:TRV_04639"/>
    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="27583" checksum="9290EE0390ED4B52" modified="2010-05-18" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALEHIDLAKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQREGRAQDGSGGALPAGNMGVQVKRNTVKIGRPGYKITKIRDPLTRQHGLLFQLQYQEITPGVKPRIRFMSAFEQKVDDPPDKDYQYLLVAAEPYQTCGFKLQAREVDRREGKLWTWFDEDSKEFWIQLLFKTEREERYSGVPGLAPASTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCH1</accession>
    <name>D4DCH1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021074.1">
        <property type="nucleotide sequence ID" value="XM_003021028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCH1"/>
    <dbReference type="GeneID" id="9576721"/>
    <dbReference type="KEGG" id="tve:TRV_04826"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="351" mass="38967" checksum="639BDBBA45A9CE38" modified="2010-05-18" version="1">MADSSEQMQAKIVAARREAEVLKDRIRHRRDDLADTTLRQVAQNNTDPLPRIGMRPRRNLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLSSRDGPTRVARELSGHSGYLSCCRFINDRRILTSSGDMTCILWDIESGAKITEFADHLGDVMSISINPTSNDVFVSGACDMFAKLWDIRVGKAVQTFSGHESDINAIQFFPDGNAFGTGSDDTTCRLFDIRADRELNVYQSDQVLCGITSVAFSVSGRLLFAGYDDYECKVWDVLRGEKVGSLSGHENRVSCLGVSNDGISLCTGSWDSLLKIWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCJ5</accession>
    <name>D4DCJ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020985.1">
        <property type="nucleotide sequence ID" value="XM_003020939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCJ5"/>
    <dbReference type="GeneID" id="9577837"/>
    <dbReference type="KEGG" id="tve:TRV_04850"/>
    <dbReference type="HOGENOM" id="CLU_987618_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="282" mass="30927" checksum="6F56FD379BC5411A" modified="2010-05-18" version="1">MKQKKRREDEEDEEEEETRQEPSLLFLLRCCFTASQSFAAVAMGIINKGSYYYEIIIIEGLKKTVDQPAPFRLFFPPWPFKERSSSSSPTSSSSSSPLLLVSIVLLAVRNSPSALHGFFSSSRPKLDRPTNQRRPAPTAPGPQPRLPTSSLLQAFSFDYNTLTHAEKNHADDGGSVSSGRSGRRPGVGTGWLSASAGFETGDAARMQLTARFFLCLTCRDAIILVVAHTTAVLLFIWPGWMGVCTSVPPWPSLVQRGTAPFCGLAGMCAHDEDTRDTITTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV1</accession>
    <name>D4DCV1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000252">
        <property type="protein sequence ID" value="EFE40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020934.1">
        <property type="nucleotide sequence ID" value="XM_003020888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV1"/>
    <dbReference type="GeneID" id="9577791"/>
    <dbReference type="KEGG" id="tve:TRV_04956"/>
    <dbReference type="HOGENOM" id="CLU_008613_3_0_1"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="753" mass="81560" checksum="98ECCF018B915A01" modified="2010-05-18" version="1">MAYKRSRAAYEDDLPGSPFVFYGTPLPPGDRDARDDGSYVPLWKQEVRDERGRKRLHGAFTGGFSAGYFNTVGSKEGWTPSTFVSSRKNRAKDSKDQQQRPEDFMDEEDLREAEEARELQTSTRFDGIGSTATDAIRDTGLVDLFSSSGDTVGVRLLKRMGWKEGQGIGPKVRRRANLDDDHHQEDENDGQTYLFAPENTPLIAFVDKSDRKGIGFEGEQRLDKAITSRSSDHTAATVPTAKPSTIEKKTQKTKPRRLGGGFGVGVLNDTGSDDEDPYEIGPNISYNRTIESSKKNSKAKRSAEISRPAIRSSNPLLDTKPVFISKRAAAGGGGAARDKDRSGFRKCHDGRLPLDGFILSVQIDLTPRNKRYDPPKVPEGWVPAKTASTQNSQTTTTTTTITTTSAPPAQQVSLAEAARASTLDPKARAALLGEAQLPGKSVFDYMTPEAREKIALATGRTDLPPALGEKAPQGFEASDSQKRRDIWNLIPSLDKDAAIQALSRGASGWMPYAEDESKRNRYRSFLEVRAGIVTDRLPDRLPGSSTDEWITELREFARAAEVFKPISGLMASRFTSSTSTSTQPGMESGSSGSGSTPLLTRREAKPEDPTESAAKLGMYGPMTRLLRPFAPARLLCKRFNVRVPTGTKHDGGGIAGLSDFAGLEAHAEPPPPLVSKETMHQLMMESGRKIIPSPASGAGSGSGSGPGPAMPAEQPPAQPAAVDPERNEALEGERPGEAVFKAIFGSDDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCX5</accession>
    <name>D4DCX5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020905.1">
        <property type="nucleotide sequence ID" value="XM_003020859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCX5"/>
    <dbReference type="GeneID" id="9577726"/>
    <dbReference type="KEGG" id="tve:TRV_04981"/>
    <dbReference type="HOGENOM" id="CLU_002329_1_1_1"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="922" mass="104245" checksum="954F32D4F9389519" modified="2010-05-18" version="1">MGDVGDHLTLREEIEKGVSDVTRAISASLRPLPVASGDGTYLPTMHTTGILDDLARMKLGDAGTLAEVAKLAATGQPIDDKRYIMERIIQLAASLPSTSKDGSALTEDLLSQLWNDLQHPPLTTYSARVLGLLGRGMQRLFSQNLYNRSTFQTRGFFLIRSWPERDLNHTLARSLVCYSISLQSSFMIFLIPSKDLFKTDPRNPTVSKTSSYLDLSPLYGSNQAEQDSVRTFRDGKLKPDSFAERRVHGLPPGSGLLLVMFNRFHNYVVRNLAAINEGGRFSKPQDGDAKAFAKYDNDLFQTGRLITCGLYINCILKDYVRTILNINRIDSDWSLDPRAENAKPFLGSPIASATGNQVSVEFNLIYRWHACISERDVKWSESIFRKIFPGRNPETIPMEEFLRNLGKFSSNLPDDPQERGLGHLKRGPDGLFNDDELVQMLTEGIEDCAGAFGAKGVPKLLRPVEILGIMQARSWNLATLNEFRKHFHLKPHETFEDINSDPYIADQLRHLYDHPDNVELYPGVVVEEVKEVMIPGSGLCPNFTISRAILSDAVALVRGDRFYTTDYTPKALTNWGLNECNYDLKVNKGHVFHKLIFRAFPHHFKRNSVYAHFPFVNPWENSKILSDLGIARKYSWDKPGRMNPPVMVNSHSACRTVLGNKRDFKVTWGETIEYLMKRDGHPFGKDFMLSGDRPANSVSRRILHDALYIDRWREEVRVFYKDTTIKLLHSKAYKLGGTINQVDIVRDVINMAHVHFCAAVFSLPLKTEENPRGVYTEKELYDIMALVFKCIFCDTDPAKSFALHEAARENSQTLGLLVMTNVELIKRTGFLAPLIDRIDRHDNILADYGIHMIQRLLDTGLPPQDIVWSHLLPTAGGMVANQGQLSSQCLDYYLSKEGSVHLPEIRRLSKLDTPEADDILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDD0</accession>
    <name>D4DDD0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000262">
        <property type="protein sequence ID" value="EFE40138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020756.1">
        <property type="nucleotide sequence ID" value="XM_003020710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDD0"/>
    <dbReference type="GeneID" id="9577454"/>
    <dbReference type="KEGG" id="tve:TRV_05139"/>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="61"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="282" mass="31733" checksum="DD9242009CD493E0" modified="2010-05-18" version="1">MPPKRRATDDDDDGEQDEYEDTPARTQTQRRWSATPESENEYQPGGHLQTSVSINVMVKKLVRLALASEYSRQPIRRADISAKVLGDGGSRHFKLVFLDAQKTLKEVFGMQMVEQPGKEKVTISQRRAPDSSTESSYIAIYTFIISLIMLSGGSISEDRLNRHLRRVNADYHTPLDKTDKLLARLCKEGYLLKVRDSDTGEEVIEYFVGPRGKIEVGVAGVSGMAKEVFGIVQGGEGDEDSEQFEKRLKRSLGIRENNAPEEENAEPEAPRRRGRRDDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDL0</accession>
    <name>D4DDL0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone h1.3., putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020695.1">
        <property type="nucleotide sequence ID" value="XM_003020649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDL0"/>
    <dbReference type="GeneID" id="9577394"/>
    <dbReference type="KEGG" id="tve:TRV_05221"/>
    <dbReference type="HOGENOM" id="CLU_1361294_0_0_1"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="209" mass="22083" checksum="258529B9C5FE9090" modified="2010-05-18" version="1">MDTLTAGEQRTFMLGLLCSTDGLNNIKVDYDKLAEKAGFKNAASASVLFNKSRRKILSALTEDGTLAPANGSPKKASDKVTKPRKSSAKGKGATITTDEESNGNEETQANPVKAPKARGGKGKAGGRVKADPMAISFLTRHRMVPIKGEVFVKEEPLHEDFAKGIIDGTLYSYSDVSLNTLWAVGAFSSGNGTTATGSPLNSEVDDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDP6</accession>
    <name>D4DDP6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020659.1">
        <property type="nucleotide sequence ID" value="XM_003020613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDP6"/>
    <dbReference type="GeneID" id="9577358"/>
    <dbReference type="KEGG" id="tve:TRV_05257"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="34794" checksum="0A6680B8B874055D" modified="2010-05-18" version="1">MPLDGVKNILLVLSGKGGVGKSSVTLQLALSLTLRGRSVCILDIDLTGPSMPRLVGKENAKIVQASGGWVPVSVYPASDSDTTTPAPIPSTDNPEGNDNSIARPYGPLRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLSDVIWGDTDYLLIDTPPGTSDEHIAIAEQLLSQATTSPTSGLTQPRLAGAVLVTTPQAVAISDVRKGVNFCAKTNIPVLGVVENMSGYTCPCCGEVSNVFSKGGGKVMADDMGIRFLGAVPIDVSFGEMVEGPRSDSGENKEEQKAEKLETNGSQPLESPLVERYQKCWSQPTFESLAKEVIQLVETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ3</accession>
    <name>D4DDZ3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000280">
        <property type="protein sequence ID" value="EFE39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020548.1">
        <property type="nucleotide sequence ID" value="XM_003020502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ3"/>
    <dbReference type="GeneID" id="9577249"/>
    <dbReference type="KEGG" id="tve:TRV_05357"/>
    <dbReference type="HOGENOM" id="CLU_067863_0_1_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056423" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="25197" checksum="FA81DF4FDEF6B876" modified="2010-05-18" version="1">MHILHLLVPLLAAAPITQGAAIRRKPQPTNLPPAFKELESLGPLSHCDISTRQLPKRGHAPELPDPEANLRLKYITFGVGTQNYTCAGGVTKPIPIGAVATLYDGSCLNNISARAMSILNYITLHTSVSSAAWVLESFLKMPKLGQHYFNGGRPFFDLTTRGGSDRAYVSVVASVPAPSGLDVPWLRLNKVEGSGIEVWLSLPPIHKVGVYYSTLKLEFVADINMNHGGNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE31</accession>
    <name>D4DE31_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">TRV_05395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020501.1">
        <property type="nucleotide sequence ID" value="XM_003020455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE31"/>
    <dbReference type="GeneID" id="9584249"/>
    <dbReference type="KEGG" id="tve:TRV_05395"/>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="551" mass="59729" checksum="25349447339AD07A" modified="2010-05-18" version="1">MAFNFNWSPLMADAGFYTRAQELLTTALNKSPKPPIIVGDITVTELNLGSIPPDLEILEIGDLADDRFRGIFKMSYSGDAYLTLKTCVQANSLNTYMVTRPSFTSPCPLAADQGLTIPLQITLSDIKLSGFVVLVFSKQKGITLVFRNDPLESLKVSSTFDSIPFVRDYLQRTIEGQLRLLFMDELPAIIHRLSLRLWVPEFRGQDVEAQADEEAGPGQDPLLSPPQDPVDASGNVLSVAQIASLSLDSGVEMHSLFSQRNLVRLATLTDSQRTLSLFTPTIHDVVFRALTGAMEQSEYHGGLISPVSPPLSRTHSHAASLQSLQESSMSKASLGSPLSGYGSLTTSAGRHPRARPSRKHKRRVVDLRKSKKSDDTSSTCTESEYTVSTDASTVFSSSARAAEKPDDPVTPPISPDATIKVKDRSRLPAVQGLGPSIIANTAQPTPSAEAEKKALSNGEPSHIPRQNTPTLEAHQQGSDNTTSLNGIPPNVLSFVAASQDRSVLEQAWMMKLANEINRRIQESKGPGSVGSASNYCRHQTRDPSPPPAYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE85</accession>
    <name>D4DE85_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000287">
        <property type="protein sequence ID" value="EFE39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020451.1">
        <property type="nucleotide sequence ID" value="XM_003020405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584190"/>
    <dbReference type="KEGG" id="tve:TRV_05452"/>
    <dbReference type="HOGENOM" id="CLU_000092_2_0_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="671"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1714"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2276"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3361"/>
            <end position="3438"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3917"/>
            <end position="3993"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4470"/>
            <end position="4543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4987"/>
            <end position="5019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="5061" mass="560582" checksum="16A7381CBA5F4923" modified="2010-05-18" version="1">[encoded data, 5061 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DES3</accession>
    <name>D4DES3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000309">
        <property type="protein sequence ID" value="EFE39648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020266.1">
        <property type="nucleotide sequence ID" value="XM_003020220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DES3"/>
    <dbReference type="GeneID" id="9582806"/>
    <dbReference type="KEGG" id="tve:TRV_05663"/>
    <dbReference type="HOGENOM" id="CLU_089419_0_0_1"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="22530" checksum="443BE16CA04F3090" modified="2010-05-18" version="1">MRVETCHFCSQPVYPSKGITFVRNDARQFRFCRSKCHKNFKMKRQPRKLKWTKTHRALHGKEMIVDSSLVLSQFAKKRNAPVKYDRNLVESTIKAMKRVEEIRQRRERVYTKRRLAGKIARDRKRAEDRRVVAEGEHLIRKELKEMAEGTKKPEDLLNRKVGLPVGEEKLRGKQKSKLLVDGGVEEEMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEX1</accession>
    <name>D4DEX1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomere and ribosome associated protein Stm1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000313">
        <property type="protein sequence ID" value="EFE39610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020228.1">
        <property type="nucleotide sequence ID" value="XM_003020182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEX1"/>
    <dbReference type="GeneID" id="9583999"/>
    <dbReference type="KEGG" id="tve:TRV_05712"/>
    <dbReference type="HOGENOM" id="CLU_043312_1_1_1"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="329" mass="36371" checksum="A9702EE6B9B57802" modified="2010-05-18" version="1">MYELLDINIYAQHTGNDPELDPNREPEPPVQVVDKTAPRRGKRDGPSEPRDTVPPPRGNRGPRLPGNEQGTFLSNKVILGISAFRDRNAGSQNNRNRPTDAPSDRAPPAAHRNRDTRGYNIRDDRQSRTDRTITEKQVEQGWGSRSGESALKDERAGEDIARSEEKEAAEANAEEPVEEPEDKSKSYADYLAEQAQAKLELAAKESRKANEGAKMDKKWAAAKELKRDDEEDEYIKGQSKETRRERQRKEKNVLEVDMRFVEAPRRGGDSSRGRGRGGDRGGDRGRGGRGGRGDFRGGRGNGRGAPRGGPSHATGPTVDEKNFPSLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF82</accession>
    <name>D4DF82_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020055.1">
        <property type="nucleotide sequence ID" value="XM_003020009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF82"/>
    <dbReference type="GeneID" id="9583819"/>
    <dbReference type="KEGG" id="tve:TRV_05828"/>
    <dbReference type="HOGENOM" id="CLU_007205_0_0_1"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="548"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="866" mass="97032" checksum="C8AB47F738B03973" modified="2010-05-18" version="1">MASNGPNKRKGAWESSSFLHRKRVKIQDARTLAVQSSDTALSKTGELDVAAFVAARQFEIRALEAGIRKSKNAATTRAFQQVPKNLRRRTASHNVKRVPRRLRARAKREMIEDNTPTVTARRRKPTQLMRLRLESARRLQGLNARSKAKRQVAAKAKLAQSPHYAGHDSEVAPRIPKIKKNKLSHPHKPASKFRNRQICKTWLPTHMFHAKRAHLTEPKNPLWRFAIPLTPTEKCYRTTHRASGARGAIAWDISYMSTIGLEGTYTSLESLLRALGVNGQNAWGGNEYKWRNGTRSLRVWVYERDGQKRPIAPVQLIWCPPKQDEDIEMTDADSVPKKLQKSKTPRRRMFLRAHPSAFLQLWEELLKVAKIQKPQVMVEDLRFEIGSIEVAGPGSTEALLGALKPALPHGVDVWPEGSPESTWLSLAGLTNPASLPRNALLSFNISDPRLRFPPKTIKIPNSAESHTKLMETLASWKPDSTQKLPPDLFSQPARRKACWQLPSQKAINRRKSEVSPGENVPPKSTDPNIPIILLASNNSSKNSNSQGSWTVLLPWKCVTPVWYYLLYYPLSSGGNPRFGGIQEQQQLAFESKKPWFPGDFPGTRAGWEWEIRERKREKEVWERKPKSKRVEYNSVNLGNGKSGEIGQGWACDWERLLSGPASMAVNHGVGPGERHNQPGRSETAEADLIMPPDLIQLDPLIASAIISKLKKSNQLPASMESLCQKPALATVSITLLGRGTPMRRSRIYRLPTSDLELRSKWLSLLNQLEGPLKKTGNDFEERAHLPIPQEEDLLGYVTSGNFNLAAGKGTGIGAILVNRICPHRTLDDSSAPSTDKDRHQEGKLMNVCIIRAAGESVGRLGRWEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFM7</accession>
    <name>D4DFM7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020009.1">
        <property type="nucleotide sequence ID" value="XM_003019963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFM7"/>
    <dbReference type="GeneID" id="9580178"/>
    <dbReference type="KEGG" id="tve:TRV_05978"/>
    <dbReference type="HOGENOM" id="CLU_597439_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="458" mass="52223" checksum="CC2E1B872CF46A19" modified="2010-05-18" version="1">MKEKAIGMSSACYKVASTFCDSICFSRERDYNDLLTPHSRPTRDRRAIPIQPGSIAKKHETFKPTNTIGVKPGTRVNQSSSVPSLPFSRPKPLELDSSTVIPDSDEELTPPRKRLKRESPEIIDLEENEPPLAVPETSDTNIIAEKSPSRTPVRAQKGIFQITSKYGRIANPRQESPAPVTPKSKPWTGRRADTFTDSEDEKPKKRSKQEQTDATGIDFKDTSTAHNRPRDRTVPAVVVKVPDPAMIQYYPKEIEKRVDCRSSRSNDRHIDDLRESPDELQGNKTVPDTWKEHSSLKREVSPSNIRHTMFTSTVDRKSSQQPIEKKSKGKPSLVTFDISVFRYGDFSAEPVSRLAYNTETSKFLVIPASVDVDSLKARSFDILRANKMDYSEVNCGKIRLSFPRSQKPGLESAYIEFPSDREREKFWRFLQRRSPSLKRHSRKRYILTLRARSLVENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFQ9</accession>
    <name>D4DFQ9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019909.1">
        <property type="nucleotide sequence ID" value="XM_003019863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFQ9"/>
    <dbReference type="GeneID" id="9584660"/>
    <dbReference type="KEGG" id="tve:TRV_06010"/>
    <dbReference type="HOGENOM" id="CLU_2484951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="87" mass="10123" checksum="79C1B467B1DC8ECB" modified="2010-05-18" version="1">MEKTREAQIFRQILSFSFFFLLLPFSFPSPSLFFFVLFMTFYIFYFSVLFIRVEPTVQLTLLDPVLTIWLAASNKAGESLASECEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFU3</accession>
    <name>D4DFU3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000343">
        <property type="protein sequence ID" value="EFE39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019897.1">
        <property type="nucleotide sequence ID" value="XM_003019851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFU3"/>
    <dbReference type="GeneID" id="9584655"/>
    <dbReference type="KEGG" id="tve:TRV_06045"/>
    <dbReference type="HOGENOM" id="CLU_037870_1_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44501" checksum="1D039816522B387C" modified="2010-05-18" version="1">MTTMESPPYLRGDGIQQDDGNEQAEEKADDIVVPDLAEDAAERKRVLNVLAQRRYRQRKREQLAELEAKARQTQPRTPESSEKVTSPGSESSTGRASVNLSETIGEQAPTPPQLDGDAPPTFGNGPLSFSSSLDGQTQILGESLLDLTSIPEFTFDPSSLSAIGSLSAMGAETPPPNLPSPPADLQLSPTARTSPSLSMLSLQFLANYPQDDTQPLSSALQSFQTSNFTFPDDKILEVPPLTLLRAMLTIATRLKLTEYIWNLAGISPFYTGPTGLGADVAQHMDLAGIPRNFHPTPTQRLVPHHAILDLLPWPSARDKLIQVFSLPVQFRPPAAADPMGLMGLVYDIEDAGEGLRVSGPDPFSPEMWEVGQLVFQRWWWAFEGSIVERSNRLRNERGKQGLILGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFU5</accession>
    <name>D4DFU5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000343">
        <property type="protein sequence ID" value="EFE39275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019899.1">
        <property type="nucleotide sequence ID" value="XM_003019853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFU5"/>
    <dbReference type="GeneID" id="9584649"/>
    <dbReference type="KEGG" id="tve:TRV_06047"/>
    <dbReference type="HOGENOM" id="CLU_054069_0_0_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="41"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31578" checksum="22631DD8C77B87F4" modified="2010-05-18" version="1">MTPPPPPAYDAPADSPIYANKELYSRIANCPSRTLQHSSLIRPRSAHAWTVRAGQVCRITAPQGAQVGDLNIWNAHNPRERFWASRTRQLHQSHVSTFDRLWSCLPYMRPLVTITADTLSTYGVDSSGGRVHDLLGTRCDPYIHHLMTGESDDFHCHSNLVRAVAQHGLVESDVHDVLNVFQVTGLDSKGRYFMGTSPAKVGDYFEFFAEQDVLCALSVCSGGDLSQWGWKGSEQMGDTTKPLGVEVYTLDDKAVLEGWKPLEPSAYTGLHGLRMPARGQDGLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV1</accession>
    <name>D4DFV1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimeric dihydrodiol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019856.1">
        <property type="nucleotide sequence ID" value="XM_003019810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV1"/>
    <dbReference type="GeneID" id="9584607"/>
    <dbReference type="KEGG" id="tve:TRV_06054"/>
    <dbReference type="HOGENOM" id="CLU_023194_25_2_1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40276" checksum="217B7C23EB010704" modified="2010-05-18" version="1">MTSRIRLGIVGLSADPSHCTNFIHKLPLTTTSLSKDYEIVALSMSSPEKAMAAAAAHGLPREKGYHKVDDLARDPDVDLVVISVKVPRRTELAMAAINAGKDIYVEWPFASNLAEAEALAKRAREQQIKSMVGLQTRLAPQVLKMKEIIQTGALGRILATNLVVTDDLFLKFHADKRHSHDKENGANIVTIAGGHLIDTMVFLLGEFTTLNAQTSMQFPKPVLKDAQGNPKTGQFNDAPDTFTLHGKMGDQNIPTSICMYSHPPTSPNLFQWIVTGEKGSLKMEGPSLMIHAIPPCLFETDSGEGPVHWKEITLENTGSQGAEYQAWLDNDRSRIVTLDDAVIRYRMIDAIFRSSETGESTSYSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV2</accession>
    <name>D4DFV2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS1 allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019857.1">
        <property type="nucleotide sequence ID" value="XM_003019811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV2"/>
    <dbReference type="GeneID" id="9584608"/>
    <dbReference type="KEGG" id="tve:TRV_06055"/>
    <dbReference type="HOGENOM" id="CLU_021555_3_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="558" mass="60791" checksum="A0204A0E7BFEC281" modified="2010-05-18" version="1">MKATSQGTMLRRLHRAVTLSSENNEAVSVWINDDIRPLPPSRRTWSTLTFVGWWSVWQLSLTNWQLGAALVASSLSVWQTMIAVILGRIIAAIVAVMIGYIGAEWHIGFPVYSRVIWGIFGAIVPTVIRIGLTIVGFAFQSYTGGLCVSAILAAIFPSFNNLQNTLPESAHVTTQQIIGWALFNIISIPMLYRRPERSEKLMIGMNVISFASLLGIMIWSLTYAKGAGDLIHQASDLQGSSALGFGILQGTTTVVGTVSIALTSQMDFSRFARKPSDQVFGQWFTFIIIGSVMPLFGCLTSSATQKIYGEPLWNPPTILAMWLQRDYSSTSRAAAFFAGLGLVSSQLALTVVDNGYSVGMDLSGLLPRYINIRRGCYVGLILGMALCPWELLASAKTFVSVISSFSIFMAPLCGIHISDYWIVRQRRLKLSDLYHSRPDGIYYYTSGVNWRSAIPWLVGWVPLLPGFIHSINPTIMMPVGVDRLYALGFPYGLLASMAVHTVINMVFPPPGIGDIDKDDIFGTFTPTEATKIGVSPSGGADDSDGNSAQGSGNGPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG34</accession>
    <name>D4DG34_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019848.1">
        <property type="nucleotide sequence ID" value="XM_003019802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG34"/>
    <dbReference type="GeneID" id="9584599"/>
    <dbReference type="KEGG" id="tve:TRV_06136"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="457" mass="49686" checksum="103C46A38E1FBF2F" modified="2010-05-18" version="1">MNSTSTLALVNGGKGGMVYMYIATFIGFFCSVISMAEIASISPTSGGQYHWVSEFASPRYQKFLSYITGWLSVLGWQGGFASICFLCGTLIQGFLQLNYGDSYTPERWHGTLLTFAIAFIATFVNTYAASHLPSLEGLILILHIFGFFATMITLWVMGEKSPSKEVFTEFTNFGGWSTVGVAVLVGQISPIFSFLGPDGATHIAEEIKDASKVVPWCMIFTAIINGSLGFVMLITFLFTMGPVDDSILTPPSGFSFLSAYLYATGSKSATTGLACIILILEVCSAISILATCSRQAFAFARDNALPFSEFFSNVNPTSKIPVNAVLATTLITILLSLINIGSTAAFNAIASITVGSLYASYVLSIVCFMYRRRCAEPLPARRFSLGSWGMGINFFSALYLSFAFVFTFFPSTKVVTPETMNWSSLVWGAVILFAIGQYILHGRKVYEGPVAYIRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG68</accession>
    <name>D4DG68_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019793.1">
        <property type="nucleotide sequence ID" value="XM_003019747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG68"/>
    <dbReference type="GeneID" id="9583716"/>
    <dbReference type="KEGG" id="tve:TRV_06170"/>
    <dbReference type="HOGENOM" id="CLU_379064_0_0_1"/>
    <dbReference type="OrthoDB" id="5378502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="826" mass="90917" checksum="715D338645965C2D" modified="2010-05-18" version="1">MRLRQRDNIRPPERYGGGDWIGNKASGRRGASRATSETPDDLPRQPHIPLIARPTAGPPPFIDYNPNSPPAAFPTLDKPRPIEMPPVNNETASSGSCENEFQSEPWSDMESSEDDDSGEDADHSVDVEDYKYLHAPTHVEWKDLNPAIQMEIIQNLTQVYTWPRVVYMLELTPQQQEEAIQSPARRQKQVEDEAQQLHEMQVKQLRALLRIDNSVLRKSRVPGQLVFRNISKQYFREAKNRATVDHFMIKASDLLAARRFLRRLGIDTKYAGEWKNDLATINQAHEENGEDEFKWILSTEETEQSSSTPSIQLGSSSPSLQPHNAGANSANGQDRCFVNRVGNPGAGTFRVPVREELNEPMHSTPLNAAQQILSRRKSAKKPDRKTPNRPMNINPASSIVRLNIGPEGAAQIRNVMHTTSSLSPQSSQNLPSSPPIPLASTTNHPPSSSLWMSQTTDSRKRPHSETAITPGSFVDEDDLPLQRVLSGPWWYNSGQVISRAGITSSQTLHERLYAARAETEIQRQSFARPIGRLPPVPQVNLPIRNSTPLNNRQATPMPYSDDTIAQTPPPGYSSPVPQRHVLPNKNFKSLLIDMPGDNVPTRMTSASSDNSEHGPPYSPISPVMGTFPVAQVQAAGGGQTQDNNLRKVRTLQESAIEDGQHGATSSILDDGVSSNTGPVGTPASLPTEAKSSRPSSVEFSHTSIQTAGEDPLLEMKFPESMENTASKAETSSNISIATTFAVCCDIPPIESMKKNECNSHLPIHSPPDTNGTGKENEFPGKSKPAKKKAKLAPTDRRRSSRLNKPATTKETRARAAASVTKKRLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG99</accession>
    <name>D4DG99_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA splicing helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000349">
        <property type="protein sequence ID" value="EFE39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019740.1">
        <property type="nucleotide sequence ID" value="XM_003019694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583659"/>
    <dbReference type="KEGG" id="tve:TRV_06201"/>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="543"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="766"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2231" mass="251963" checksum="E9DACB68896929CB" modified="2010-05-18" version="1">MADPNNVAQYKYSAMSNLVLQADRRFVTRRADEVTGDPESLAGRLSIKDMGVHAMRPEVKQKKASAPKDIERGGIREGADVLKREQRKRKRGEQAQLRGVGILSAADALIEGLKYRPRTAATRATYDLILTTTASHLGDVPHDVIRSAADAILELLKDENMKDFDKKKEVDDLLGVTMGPKEFNELVNLGKKITDYDAQDDDETNGAGAEGEDGAELDERQGVAVVFDESDEDEDEMRPDAEVKDEGESSEDEDMSDEGPADEGEAAQNIPEDVMGMGDEDMIIDAGAGVAAGKSDADTKIVPAREIDAYWLQRQIGNIYSDAHVQHEKAQEAFTLMSEQSEDGTPKPLRDVENDLMELFDYDHPELVGTLVLNRDRIVWTTRWRREAEDSDARRLIENQMIESGQRLLLDELTGKVQDATDRPGKKMKVDSMDVDTPMAKKEEEDEAKPRTMVGGLPPSKVINLENLVFDQGNHLMTNPNVKLPQGSTKRTFKGYEEIHVPAPKPRRDDDIRRIPITELPEWSRPGFGNTDKLNLIQSKCFPTAFNDDGNMLICAPTGSGKTNVAMLTMLREIGKNRNPETGEIMLDDFKIIYIAPLKALVQEQVGNFGKRLQHYGIKVSELTGDRQLTKQQIADTQLIVTTPEKWDIITRKATDTSYTRLVRLVIIDEIHLLHDERGPVLESIVSRTIRKTEQTGEPVRLVGLSATLPNYRDVGSFLRVDPIHGLFHFDGTFRPCPLKQEFIGVTDKKAIKQLKTMNDICYTKVLDQVGANKNQMLIFVHSRKETLKTARYIRDKAVEMETIGQILRSDAASRAILAEEADSVNDPGLKDLMPYGFGIHHAGMSKADRTSVEDLFADGSLQVLVCTATLAWGVNLPAHCVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQYDSFGEGIIITTQAELQYYLSLLNQQLPIESQLMSKLADNLNAEIVLGNVRSREEGVEWLGYTYLFVRMLRSPGLYSIGADYEHDTSLEQRRVDLIHSAAMVLEKSNLVKYDRKTGKLQATELGRIASHYYISHSSMLTYNHHLQPMISTIDLFRIFSLSEEFKYIPVRQDEKLELAKLLSRVPIPVKESIEEPHAKINVLLQAYISRLKLDGLALMADMVYVTQSAGRILRAIFEITLRKGWSSVAKTALDLCKMAEKRMWPTMTPLRQFPSCPRDIMQKAERIDVPWASYFDLDPPRMGELLGIPKAGRIVCDLVSKFPRLELQAQVQPMTRSMLRVELTITPNFTWDDSLHGNAEAFWIIVEDCDGEDILFYDQFILRKEYAISEMNEHLVEFTVPITEPMPPNYFITLLSDRWTHSETKVAVAFQKLILPEKFPPHTPLLDMQPVPVKALRRADYQGLYPNWEKFNKVQTQVFKALFDSDDNVFVGAPVGSGKTVCAEFAILRHWSKEESRKAVYIAPFQELVDQKLADWTARLTSVAGGKSIQKLTGETTADLKILDRADLVLATPIQWDVISRQWQRRKNVQAVELFIADDLNILGGQGGYVYEVIVSRMHYISLQTEQELRIVGLSVPLANARDIGEWLGAKKHTIFNFSPHVRPVPLELHIQSFTIPHFPSLMLAMAKPAYLSILQLSPDKPALIFVPSRKQARSSALDLFTACVASENEDRFLHADIDEIAPLLDRIEEKALAESISHGIGYYHEALSTSDKRIVSHLYKIGALQVMLASRDVCWELDLTAHLVIIMGTQSFDGREHRYIDYPISDILQMFGKATRPREDRIGKGVLMVPAVKREYYKKFLNEALPMESHLQLYLHDAFVTEISTKTITSTQDAVDWMTYSYFYRRLLANPSYYGLTDVSHEGLSTFLSELVENTLKELAEAQIVDMDEDENISPLNAAMIGAYYNISFITMQTFLLSLSPRTKLKGMLEIVTSATEFESIQVRRHEDYILRRVYDRVPVKMAEPAFDSPHFKAFVLLQAHFSRLQLPIDLAKDQEIIVGKVINLLSACVDVLSSKGHLNAMNAMEMSQMVVQSMWDRDSPLMQIPHFGPTAIKAANEFKYVPVNIPQIKTYGNANNCARIRDIFEFMEAMDPSENKDYSTLVKRLGLDNKQLAQAAAFTNNKYPNLDLDFTVLEPEDITAGEPAYLKVKIERELDEDEEPDTTVSAPFYPAKKMENWWLVVGEEKTNSLLSLKRVTVGRKLEMKLEYVVPSPGEHELTLYLMSDSYVGVDQDPTFKITAAEGMDEDEDEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI0</accession>
    <name>D4DGI0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000358">
        <property type="protein sequence ID" value="EFE39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019694.1">
        <property type="nucleotide sequence ID" value="XM_003019648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI0"/>
    <dbReference type="GeneID" id="9583593"/>
    <dbReference type="KEGG" id="tve:TRV_06284"/>
    <dbReference type="HOGENOM" id="CLU_1880489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="136" mass="16164" checksum="D9D6B5FF8AB9B93D" modified="2010-05-18" version="1" fragment="single">RKDAGKRKKGEEKKRERGKRKERQRRRRNLRAAARRRRGRESDLPLSLSLSLRVPPWKIFLAAASAISSLKKKRKKKKKKKRREEERKKKKKRSREEEDRWERKSSGDRPSFWQLSVVSTGFLEAPVPAASQQTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI1</accession>
    <name>D4DGI1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019656.1">
        <property type="nucleotide sequence ID" value="XM_003019610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI1"/>
    <dbReference type="GeneID" id="9583587"/>
    <dbReference type="KEGG" id="tve:TRV_06285"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="35"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="436" mass="48384" checksum="7FE919216803D844" modified="2010-05-18" version="1">MAPLQPESLFCKLDTAPADEVFALMGDFAADTHPDKVSLGAGVYRDNEAKSWRLPAVKKAEQLLLDDPTLDHEYLPIPGYAPFYNMARDLIFGTGESSIPKERIASLQTISGTGANHIGARFLADHLPKLSDPNAKRTIWISDPTWANHHLIWNLVSSGTSGSPIQVKTYPYYHEPTRSLNFEGMMKELEAHAVAGDVVLLHACAHNPTGIDPTRAQWLRIADLCESRSLFPFFDSAYQGFASGDLDNDAWPIREFAKRGMELCVAQSFSKNLGLYGQRTGAFHLVCRNAEATVCARSQVVELQRGEISTPPSYGPRLAAKILSDPALVEMWKEDLITMSSRIKSMRRALYDELQRLQTPGTWEHIINQIGMFSYTGLTKEQVRLLREYHIYLLDSGRISIAGLNTSNLKYVAEAIDSVVRKTTKTSNGSNGSNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGW8</accession>
    <name>D4DGW8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06423</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019549.1">
        <property type="nucleotide sequence ID" value="XM_003019503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGW8"/>
    <dbReference type="GeneID" id="9578323"/>
    <dbReference type="KEGG" id="tve:TRV_06423"/>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="204" mass="22345" checksum="D2AC0863D6FA2528" modified="2010-05-18" version="1">MFAFASSATNDEDPSRGGYRTEPRRRIAAARTKMASSIVRPSVSALRQSCRVAGFQHRSPLAALSANQLQRTWFHASSKKDILPPLPPNDAAPIPPTSPTHGSYHWTFERVVAASLIPLTIAPFASGSVSPVLDAVLCGTLVIHSHIGFQAMIADYFRPWRVPKTSAFLNWLLRGFTLATAVGLYEFETNDVGVTEALKRIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH01</accession>
    <name>D4DH01_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000366">
        <property type="protein sequence ID" value="EFE38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019519.1">
        <property type="nucleotide sequence ID" value="XM_003019473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH01"/>
    <dbReference type="GeneID" id="9578208"/>
    <dbReference type="KEGG" id="tve:TRV_06456"/>
    <dbReference type="HOGENOM" id="CLU_036110_1_3_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="375" mass="41489" checksum="2689941281BCA983" modified="2010-05-18" version="1">MKEEISTIVHVDKPRAVKDPEYARSLSKTPSFCVYDERFIGDVVGSDPKIQLVEERREKGEQFAHEAGVYIRETNSVYFTSNFQTCDPIDLYAINCDTHEIEKLDYPDVVQANGACNYPGKTASTHSPGAGTGGEEPDRLLYCSQGDQSTPSALVLVNPVTKESEILLNNFYGREFSSVNDVVIHHGTGDVWFTDPTYGFEQGFRPEPVLPAQVYRFRPSTKDCYVLADGFDMCNGLCFNPDYTLLYVTDTGAVKARSYSGNGRKFQANYQNAGTIYVYDVVDGGTRIANRRMFAFCDSGVPDGIKCDENGYVYSGCGDGVHVWAPDGTLVGKIIVGCTTANFCFVKGGIWMFSEKDLYFCKVKAKGALVKTECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH99</accession>
    <name>D4DH99_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="ACYE01000375">
        <property type="protein sequence ID" value="EFE38778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019423.1">
        <property type="nucleotide sequence ID" value="XM_003019377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH99"/>
    <dbReference type="GeneID" id="9577872"/>
    <dbReference type="KEGG" id="tve:TRV_06555"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="205"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="336" mass="35649" checksum="50B192E2B3E3238B" modified="2010-05-18" version="1">MINRLLPRVRALPRLSSASSTRLFSSSASRHATWGFIGLGQMGYPMARNLRAKIPASDTLFVCDANPETTARFTAETENVKVASGPRELAEQSDTVVTSLPEPQHVKSVFHVILKDGLPKLAQDRLFIDCSTIDPSSSREVAAAVQSTGSGRFVDAPMSGGVVGATAGTLTFMLGAPSDVPGLVERAEAALLLMGKKVWHLGDQGAGLSGKLANNYLLAVANIATAEAMNLGIRWGLQPAVLGQMINSSTGRCWSSEVNNPAPGVIEGSPASRGYTGGFGVSLMKKDLRLAVEAARESGTALELADIVQQVYEATEKEHRGKDFSVVYQYLTSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHD1</accession>
    <name>D4DHD1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000378">
        <property type="protein sequence ID" value="EFE38739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019384.1">
        <property type="nucleotide sequence ID" value="XM_003019338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHD1"/>
    <dbReference type="GeneID" id="9577786"/>
    <dbReference type="KEGG" id="tve:TRV_06587"/>
    <dbReference type="HOGENOM" id="CLU_2322049_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="99" mass="10689" checksum="88868CB63CDB9DC3" modified="2010-05-18" version="1">MSSISINLLAGQLPSMSFNLKKQQNSLKQARKRRERERNKGKYKGKKKEPQFLTSADPANASLAATAPSATLGLSTEIPAAGIDAFHGHGAQIRSLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHE1</accession>
    <name>D4DHE1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase HosB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000379">
        <property type="protein sequence ID" value="EFE38723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019368.1">
        <property type="nucleotide sequence ID" value="XM_003019322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHE1"/>
    <dbReference type="GeneID" id="9577771"/>
    <dbReference type="KEGG" id="tve:TRV_06597"/>
    <dbReference type="HOGENOM" id="CLU_001880_0_1_1"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="315"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123662" checksum="38B5B997866513D9" modified="2010-05-18" version="1">MADNKGKSKEKDTSGESRNVDVVALDSSNKDHLEGQDREVNEALLSAIMASPQQRSSQCSGQEELLKSFNKLNITTMNDHNKNNNKTPSPSLSPLQSPYHKPETTHSILRNDPGARPPSRQQQQEQRAPRRTTSTTSLRDERRSSIQSLQKRASISSLRSVQNLTASSSSPRQSLSRRSSAQHLASSPGASGRPISPLAEMAPPPAPTASEIAAQYWSRELALHQTTELQSSTIVIIQDACYGHRFSRPRTSKDDLNLIVERPERMQASILGVAAAFIRMGLRYGSNEFAPHPNLDLQRLPAPPFQIRKSVRTMSLDSPAVTHIHGTKWMEDLRLMCDAAEGRLATNGKELVRPSSSGRETRAKAAPQLHEWDLYLCPESLNAFEGALGGVCDAVDSVFTSPSIRRAFVCIRPPGHHCSGSFPSGFCWLNNVHVGISYAAMTHGLTHAAIIDFDLHHGDGSQAIAWKQNERATAKNAAGCEKTAIGYFSLHDINSYPCEEGDETKIRNASVCIDKAHGQSIWNVHMEVWKTSQEFWKIYETKYTILLEKARAFLRAHSLKLRSNASPNAPQPKAAIFLSAGFDGSEWEGANMQRHKANVPTDFYARFTADVVRMAQEEDLAVDGRVISVLEGGYKDRALTSGVFSHLSGLSDCPEIKVERDPSSSRLAAEMYRRLGLNEESKHGTSADGTSNFNYDPIWWAPALLEELEVLVNTPPTTPRKPRGRGPPTFSAPTQASAAKVTTPTRPHRSPSSNHTREPSPPPLPRVEWATAAFELSKALIPTDRQIASCQHADLKVVPSQSRPASRLASAANRQQPRASERGTSHMQLRERKQKAPAATTGSLASSRSSTVSTRRTTIASSNDLPSTNMTGSGEPANSPSVRRSSRRISMTSTASTSPVSSAGKINQPKTRETPLRPSPSRASSGSESQNSATRARTAVTNRAPTPVRNIPKKPQGNGGNVDNLSASVKRLNIKLNLPSPEENAAREAKLAQDRKKGLQAASQSSQRKPASRAAPGTKTSAKETTERQSRSNPHSTATNAKKTSPPGKPNLALSYDGAYDEDPITGHEQESLASTPNEATGNTNTMPSPPLTPDTAPEPETPTITVRSPPASAHQQLPVFTATSIIPFAPSQNPPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHG9</accession>
    <name>D4DHG9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000380">
        <property type="protein sequence ID" value="EFE38699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019344.1">
        <property type="nucleotide sequence ID" value="XM_003019298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577666"/>
    <dbReference type="KEGG" id="tve:TRV_06625"/>
    <dbReference type="HOGENOM" id="CLU_000901_0_0_1"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056279" description="Sister chromatid cohesion protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1566"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1605"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1631" mass="180213" checksum="5E8FDD8AA0FABBC5" modified="2010-05-18" version="1">MYAMPLSLSLSLSSSVFMLGCIFANVAADPSPSSPSPPKQVQRSKPAPAPDQRNRNTPDDGGKAVSKIPDPGMAVKPVVLVPAFPDPSQLSEYQHIPDTYAKPRLLSPATQHAESVKIRDQREIINTAVANLQSLLQDVFESEDEMQLESSQDPGQNINKYFYTMDTTEDSRPCLTSETHKQLQKAFRSVSGYGKLGDIPNEFITRIQKLCEAPIMAAQSVDITVESDMSETSMENWTKQLGELENALLAMGTLLHTMDGRTDAKELCSEDMIQLIPTALNHVFERCVIPAVECRPSGKDTALFSIFTSQKQAIASVTLQSRKILSQLGVFLSAVDLVEGAITAMEFMATKLIFVENAHHEKDSTIGVQRFEAVRRCAMDMLAKIFAKYAEQRSFILDEILVSLEKLPSTRQSARQFKLTDGKSIQLLSALVVQLVQTTAVRSSSQHAAKPKLRSSGQNEEGEDDDESGSEDEDDTSPFVNLSRQVDQAYDNAVRSAQYITRFIVQRAMTSTKTGDQPYRNILDLFTEDLISILGSSEWPGVELLLRVFASQMVGIAEHDKSTANAKNMALELLGWMGSAISDLTSTAQHLNNSTDDGDSELTEYIRQLFDNHVNRSLHVQDLVVHDGPYRISLEYLNTKDVAGSHLPSARDYLLTSWTKTACTVYCDASQNEAISRGSSARKLASSLTSLISEPQWLEQHREYETISTQQARFAYLIVILSSGFCKAFDTIVKVLLSSISSDQAKVRSRSLKSVIHMLERDPSLLDRDDSIMDLILRCAADSSPMVRDSALTLTARCISLKPALENECCRAILACASDPTVGVRKRCIGLMRDVYTVTSNKDLRISIIEQILRRVQDHETNVATLARQGLEELWLSPLHSTDNFDTPQAKVSLGELVELFIGAVQRGDEVVSNLESFFKAALHPESRAVVQNFKICKAAVATLFENVVHGSNTDQRSLQSHLRTLTVFAKSNPKLLTPDQLETLHPYIGHLSSTDDLLLFRSVVVIYRCVLPNLSSAHNNLLKEIQNDLFKSVSKLARTELNEVMACLWTINGVLQNTERLVKLTISVLKGIYQASNTKLDASTSGDALGRVRSYIRIAGCVGKHCNLEKFSSFFAQAFPKSNTESVSGLMVEFIAPFASSIYPHELRVMSLESLGSICETWPEQYGKEKARLAFSSVFKEDSGDLQDIVLKSFLTFFSIHEGKSEKFVNTAETNGDSADTSRLGGSLKASANDGAAALIAQNFLPQMLHAAMSKQDTFALTAIELIASINRQGLIHPKECAGVLVSLETSPNSTIATTAYDIHKMLHQQHESMFDREYMRAIQEAFYYQRDVIGDSTGASVRPFTPKLALLFDIVKLSNSKYQKKFLTNFCSKANFELKKLDTSGNPPEYLELTRFVCQNVAFFDYAQVAELLAAISCMERIVGTTGTAVAHSIDTEILSVKVPEAIEQLGPQEGEPNVIPAPIDPTVLKRLATAGAGLSMLWETRSYLRRLYNLNFHSLQKEGKVAAKELNKPASKVPGINGDRFWDTIARIMKSLDTTDSMTNMCREFSTLMSVDDELKIAGDEDRGSPDPFAEVNDVSSVIGTAGRPVKRKSSVSSSTTPKKRQRGRPKLGSKRPSEDSDEDSDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHQ8</accession>
    <name>D4DHQ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 7">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 7"/>
    <dbReference type="EMBL" id="ACYE01000384">
        <property type="protein sequence ID" value="EFE38607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019252.1">
        <property type="nucleotide sequence ID" value="XM_003019206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHQ8"/>
    <dbReference type="GeneID" id="9577500"/>
    <dbReference type="KEGG" id="tve:TRV_06715"/>
    <dbReference type="HOGENOM" id="CLU_079443_4_1_1"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="35220" checksum="450BB599F16C1D0D" modified="2010-05-18" version="1">MPFIENQATTAEPIVPVDVKGKDAFHKLVDDLSAVLGPSSGLDSDDVDPMDIQKLMEGYVSNHEEWQRYALADESRAYTRNLVDEGNGKSNLESVVRREQEDHLANMAKLNAAHPRLEPGVLTLSFSLLSRWESKVERAKPKKKRDEEMEKRERAKEPTILHGSLKEHRYDWPEQDKINNGEACPLTVTKETTLRENEVAYMSDKVSLPLSCMCVCIRKRMLAWFAWLTLNIQLGLHKISNPDPNDFAISLHYEAYLFLLVLSVFADIRHPVYTPPNAAHFGCSLFDEKTGKSHHIKQCTFFSNRGLKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHX2</accession>
    <name>MIC60_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MIC60</name>
        <name type="ORF">TRV_06779</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019173.1">
        <property type="nucleotide sequence ID" value="XM_003019127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHX2"/>
    <dbReference type="SMR" id="D4DHX2"/>
    <dbReference type="GeneID" id="9577170"/>
    <dbReference type="KEGG" id="tve:TRV_06779"/>
    <dbReference type="HOGENOM" id="CLU_008024_2_0_1"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000406676" description="MICOS complex subunit MIC60">
        <location>
            <begin position="12"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="161"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="367"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="683" mass="74802" checksum="F9FD57BD85FA89AA" modified="2010-05-18" version="1" precursor="true">MLRNSIAPSRGLGSLARQRLTTSGRNLITKRSYIEGKSAAWPSGRSIASVLPARKTSCATFTTSATRGNEQNIRSPPSPSSASAISPEGISRPASSSPAGQTSPGSSVNPPEPPKAQTGAPPPPPPPPPAPKAKGRFGRSLLYLVLTAGVAYAGGVWFSLRSDNFHDFFTEYVPYGEEAVLYFEELDFRRRFPNATRHINTRPAAPRDEGEKVTIPSKSGVSWKVAENEGTSDVTHKGRHMSAVDAEVFRTGGDAKSASNKPTTEDKKGSEKTGSKKDESKERVPVTDTKKSTVSLDEPRKPAVATVSSIEPLAALQDDPIIQELTKIVNGLIAVINADESASKLAAPIAKAKDDFLKLGEQISSIKKEAHIAAQEEIKNAHKEFERSATELVRRIDEVRSEEAAEYREEFETEREKLANSYQEKIKTEVERANAVAEQRLRNELVEQAIQLNRKFLSDVDTLVEKERQGRFSKLSELSAQVAELEKLTAGWNEVIGANLTTQQLQVAVDAVHSALESESMPRPFINELLAVKSLAGQDPIVNAAISSINPTAYQRGIPSTAQIIDRFRRVANEVRKASLLPEDAGVASHATSYLMSKVMFKKEASSSGDDVESILTRTEKLLEQGNLDDAAREMNALRGWSKLLSKDWLADVRRVLEVRQALEVCFLFLLPTLSLLIYYNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH2</accession>
    <name>D4DIH2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small G protein signalling modulator 1/2 Rab-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018969.1">
        <property type="nucleotide sequence ID" value="XM_003018923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIH2"/>
    <dbReference type="GeneID" id="9582130"/>
    <dbReference type="KEGG" id="tve:TRV_06981"/>
    <dbReference type="HOGENOM" id="CLU_004457_4_0_1"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small G protein signalling modulator 1/2 Rab-binding" evidence="3">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="505" mass="57017" checksum="99BAD396A040BD46" modified="2010-05-18" version="1">MAANTTPPASPPSPSASFYDVSDDEEGDYNTVTHTSTGKGVRLLYSKSKVYVHPTASSKDNIPGFIALVQQKPAPSAQRESTSSSSPSLDKTVDPSSLLLSWVPEASLGDERDVYVKVDLSDDNSPPRTSYLVPPLPTTLSSAGPIGSYAFAIPLSRIYSLLVRPPSLGWWFGSVVINTKAGDSFPALFFHDSECESTILQKKKRTKENFDPFADDGSMFWGGDEVLRWLRRYVDVHRSGEDPSAYLINPTEEDKTAFGQAKGKLENSSGQPGSSKPPKDATMDPFTKALKETRWMVLEQFSKITTFTRRTAQDIADNPRLPPQVRRLMRNPEVQTLQDEFDSARLYLARWAMGIAEQSERERNQRIWTANDVLAMENSSVGEFEILDMEAAQMSISDKRKIVTLEEWNGWFHKTTGKLQITVEEAKERIFHGGLEPNDGVRKEAWLFLLGFYDWDSSEDERKAIMNSRRDEYIRLKGAWWERMIDGASTPKEQEWFREQKNRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIX0</accession>
    <name>D4DIX0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terminal deoxynucleotidyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018863.1">
        <property type="nucleotide sequence ID" value="XM_003018817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIX0"/>
    <dbReference type="GeneID" id="9581507"/>
    <dbReference type="KEGG" id="tve:TRV_07131"/>
    <dbReference type="HOGENOM" id="CLU_008698_4_1_1"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="682" mass="76492" checksum="0B2CB1525A1BFDDF" modified="2010-05-18" version="1">MEFHDIPGFPDADIEDTIDLSSCPTIFVLPTHITLEELHAIEGTLSKCGAPLTYDITEARLAIGKVSHEKRATLELRSKGLWTEGITIAEAMDEPAQKRRRLDDNKNIRVIRLSWVHESLKAKEPLPFEPFTVYEGRKIPKPPTASLEKALSSTTSPDRCAAQETALYQSPGSSILERARGDTPSSSMRFIPSSPSRRVKATSGSPSVIKQRPKLYRASTSDFEEEASIPDPPEWVRNKVVYSCCRSTPLHSPNAEFIGQLLKIKKIRELTLDEVGVRAYSTSIASLSAYPYKLKSPEEVLSLPGCENRIANLFTEWKHSKDGILESTLPLTTDPALKVINSFHNIWGVGAKSARDFYYQKQWRDLDDIVEQGWDTLSRVQQIGVKYYEEFLTGIPKEETVSIANTILHHAKLVRPDSDFDGEGVEIIIVGSYRRGKEESGDVDVILTHRDERVTSNLVFDVVASLEQEGWITHTLALHLTNTNRDQQTLPYRGESSGKPRFDSLDKALVVWQDPNFDDNPSSPSSSEDSGEIKSPPLAPKEKAEERKMNEDVKRQELTSQDSSRDTLAGELGTSTAPIAVNPRKANPNLHRRVDIIVSPFRTIGCAVLGWSGDTTFERDLRRYAKKMHNWKFDSSGIRSREGSGGRIIDLESKGKTWQEREKLVMEGLGIGWRPPTERCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJE4</accession>
    <name>D4DJE4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000436">
        <property type="protein sequence ID" value="EFE38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018678.1">
        <property type="nucleotide sequence ID" value="XM_003018632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJE4"/>
    <dbReference type="GeneID" id="9580831"/>
    <dbReference type="KEGG" id="tve:TRV_07310"/>
    <dbReference type="HOGENOM" id="CLU_727564_0_0_1"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="378" mass="43125" checksum="22A56DBA7AEEC4D9" modified="2010-05-18" version="1">MSSDKMVDDSNWLQPVLGSYQAEAVAQSLARAQEFDLIPVGEKERRPSSWTIRAIIRPEEPLYAVVVHHTITSMCKGEIACWTYISQGMERVGQKEVVFTVSRNTESERKKDFPNDPLRWIEIVYSMAKGGCCVGEFEHTDFQVADFLGRSDVNWIVYCPACPIPNVDDFLLPQDYLQAIPLLVAEAEVAEKYGLMRTLGHLGASERWFPWPPWFDRYRKPCITASQMQGSIKEEMEFQHIKGLSCIKKGSNIILRVPKKSEPLLVEALLRHSPDQAFPLNTVHHINSDSGLLWDNRDPQPRGYSAGNSNECMNLNYFAFCPGHDVDELVLVEDGYMSDETWLKIRSCIKNMRPCHISLPELQFLLRLEKPSVPGYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK40</accession>
    <name>D4DK40_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018433.1">
        <property type="nucleotide sequence ID" value="XM_003018387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK40"/>
    <dbReference type="GeneID" id="9584362"/>
    <dbReference type="KEGG" id="tve:TRV_07561"/>
    <dbReference type="HOGENOM" id="CLU_045153_0_1_1"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="195" mass="21677" checksum="64BE6F47A934C14D" modified="2010-05-18" version="1">MTLEEAKPVLAAIFTVSAAINTAISAFDLEIRSTAHQTQQSRVYALINTTSDPMMQLATTYSADEIAYVKRLLDAMFESNNTSRCEAMVVSSIEAVRLARTGANLNRRQSEGVPQSGTAQPLSMREAEGMLSRLVGEGWLERSRAGYYSLSPRALMELRGWLVETYNEEEDENGDTRQNHKIKTCFACKEIITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK46</accession>
    <name>D4DK46_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018413.1">
        <property type="nucleotide sequence ID" value="XM_003018367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK46"/>
    <dbReference type="GeneID" id="9584341"/>
    <dbReference type="KEGG" id="tve:TRV_07567"/>
    <dbReference type="HOGENOM" id="CLU_093582_1_0_1"/>
    <dbReference type="OrthoDB" id="3348320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24415" checksum="CA3E89CBB82E2555" modified="2010-05-18" version="1">MERQTLTIEEMQKGLVELDRAMGENEMIYAFSPITVISPGGFLAVSYLKSRETTEDIDIIIDPQWTGDKDIIPALRELFSSVGKKLGLNRKWLNDDVSLFLTQKAREQIFNAAGNQNIILYEGPNLRVLGAPLEWGLESKLRRINSKPDHPKVPTDIQDILIILKLLIERNNGPLNRRQVRERNTNGFDILPSEETLDLVANAYQNKYGEYPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKI6</accession>
    <name>D4DKI6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018258.1">
        <property type="nucleotide sequence ID" value="XM_003018212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKI6"/>
    <dbReference type="GeneID" id="9579877"/>
    <dbReference type="KEGG" id="tve:TRV_07708"/>
    <dbReference type="HOGENOM" id="CLU_002458_0_0_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="42"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="218"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="433"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96634" checksum="1C3638F6D3406BF5" modified="2010-05-18" version="1">MTSRPPSSLAATTTTSALVYTFASDQPDGPRYQDQTRGQRDLLTQIVISVSFGLSAFITFCFLRPKWSALYAARRKMRTAASRLPDLPDSLFGWIPVLFKISDEEVLASGGLDAFVFLLFYKYSIHFLSIVFFFSVVVILPVRYSYTGERGYPWDGDRGDKPGGDSDKKQKTDPTFLWLYVIFSYVFTGVAVHLLIRYTNRVIQIRQKCLGGQTTMADRTIRLSGIPVDLRSEEKIRGFIEGLEIGNVESVMLCRDWRELDRLMEERKRTLQRLEESWAKYLRYRKSKPGGLASRTNRIAPQTNTGDTAEDSCLLSDEPNTHQNYILENPGVRPRTRIWFGPLKIQFKSIDAIDYYEEKLRQLDEKIEIARQQECTPGALAFVTMESIAACQMAVQAILDPWPMQLVANLAPAPADVVWQHTYLSRAERMIRGWTITTVICVLTVFWSLLLIPLAYLLNLETLEKIPDANWPSYIDAIFALAGSSIYIRLYVDFLFPLKYILIPGPLANHLVILGLANVQGMTSQGDVELSVISKNFFFTFFNLFLVFTVFATASNFYGLWENLRDVFKDTTTIAFALARSLEKLAPFYTNLIVLQGLGLFPFRLLEFGSVFLYPFQRMFAVTPRDYADLRKPPIFSYGFALPPTILIFIVCLVYSVFPSSWLVCLFGLIYFSIGQFIYKYQLLYAMDHQQHSTGRAWPMICSRIILGLVVFQLTMIGSLALRSAITRSILIVPLLAATVWFSYFFTRTYEPLMKFIALRSIDRSRDADSNLSPTPSSNFSPPSQWDRDAIPLRLRGRDIAPRLRKYINPNLIIPLDPAWIPGQPENYDNDLASFSQNGISVPTQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKL9</accession>
    <name>D4DKL9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LipA and NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000473">
        <property type="protein sequence ID" value="EFE37605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018250.1">
        <property type="nucleotide sequence ID" value="XM_003018204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579864"/>
    <dbReference type="KEGG" id="tve:TRV_07741"/>
    <dbReference type="HOGENOM" id="CLU_001668_1_0_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1428" mass="158179" checksum="0EDC65550503C17C" modified="2010-05-18" version="1">MTTAVTKRGVEVKQFGLTQLYQTSSPAVDIVFVHGLNGSAYHTWATKKPPEVFWPSDLLPGALRGLEVRILTYGYDANVASFSGGTSKDKLHNHAEHLITSLCALRSGTESTERPIVFVCHSLGGLVVKKALCCYTRISHQHTQHLRSIFVSTFGIIFLGTPHNGSSIAKVASTAQSFINTVIPKRLLSTSPQLVQVLQSDNEHLQVINRDFVQIMDRFHIYFFHESKPMDIGSTRAFIVEESSAAPVWDGVERMGIEADHGAMCRFADKNSPGYDTVTEAIRRYSSTAGPTIVARWQQAKQEYLLAMQAGLQVQQLNAGSAFDLSADTQDPLDLSRISLPGPHDPIFTNPEALRHVNRPLLLGNNDDSLVTVSPPGFHPNSVFFGMQEEMDRLRRVLSDERKRVLGPATVLIHGSPGSGKSHLARQYMYDHDKLYPGGIFWIDGKSKESRLNGIWEIAVAASILLEDREDRDPRWLMAHKYTANVKRWLESRDNWLLIFDGLAFEDEDDLNEFKNFLPFKPNTSIIYTSVDRTLRQKQRLFEPYGLAVQPLAVEAACQLLFTELGISKPNTRQTQKARELVRYYECLPLAIHALGHRLNASGKPLETYQPGSHLTDSRLAEPYREIMTDLNSNQYTEALQLIYILSFFGHNVPVGMIHLGRKALAEYKVEIRTLERYGSTERHIDNTFAILIKYGLIERSFDAYSEVSATPTSEVDRRGIERRSTTHSQSASSQDAIMGRPRTEIDVLKIHSVVQGFCRDELIVEGAKHFWYWLGIATSLFCLSYKNATTQIRAIKNAGLVRDYHKSEVNLELHHECLKKMLLDIEEEIRHRSPGSSQEWFRHQRSIFDHTNSMSSFSDSIASTSTRSTWERDVGAECTDSPQEIVSPQGSVQPHSVLHGNTNVALKSQRRKFPQEERPSTPGKKRGSFLSAFKEPLRRLREQRKNLGESRPATPTVSVSDGSRRNSSILVQGSPSQRKPSDAGSAGKPVAPLAQQHSSASSSKNSGTSTGPVPTKPGSSNKSNHGPSYAAVVGGATHAGTKPPSRQQRSNLTQRPMHTDSPPLPDVEEIKRLSASLMGGAEMNLSLSTHSDPGLPYPRRISASDRGSPTTPNSPFGIEQDSQRPPISNQQHFSDSNVGPPYMGPNPLPIPYEPNIEITQMPPRRPSAFTPPPLRAVGSRNSLPHGYSSQPMSREHSGLSHQSLQADPGRFTPSPPSASAPRAASFSHSNRTAVVPRIDTRIRYPASECAIDSATTTPTLDESQFLPLSNVTTGPGFMVDRGDGISGVVEFNPVQYTPPHIRFGEFEPVNVEAARQRAERALRGEQLIRQAQVQAQVEAQAQAQAQAQAQAQAQAQPRAAPYPDHNFMPTASDPQQLADMMRQGFATPPQQRAAEQLRQGGARTRIRSGSTPQVPDWTGLGIHHRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKR2</accession>
    <name>D4DKR2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_07786</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000479">
        <property type="protein sequence ID" value="EFE37566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018211.1">
        <property type="nucleotide sequence ID" value="XM_003018165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKR2"/>
    <dbReference type="GeneID" id="9579582"/>
    <dbReference type="KEGG" id="tve:TRV_07786"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_3_1"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE37566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="539" mass="61875" checksum="E7BF6215166E1343" modified="2010-05-18" version="1">MEGKLVQAVTEKKPVPEIDFTLHTMEDGTQVSTQERVCKEVQAPAFNTPSNEQFWSSEDPTKPDLKFLKQHFFREGRLTEEQALWIINTGASILRSEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPSETRYLFLGDYVDRGYFSIECVLYLWTLKIWYPNSLWLLRGNHECRHLTDYFTFKLECKHKYSERVYDACTDSFCALPLAAIMNKQFLCIHGGLSPELHTLEDLKTIDRFREPPTYGLMCDILWADPLEDFGQEKTGEHFIHNNVRGCSYFFSYHAACAFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNTCSKEELEEETPLSASEAPPSPTLPSTDPESTEFKRRAIKNKILAIGRLSRVFQVLREESERVTELKTATGGRLPAGTLMLGAEGIKQAIHNFEDARKVDLQNERLPPTHEEVTKRAEEDRRQALERAAQEAANDTHLTNVARRISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL65</accession>
    <name>D4DL65_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018051.1">
        <property type="nucleotide sequence ID" value="XM_003018005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL65"/>
    <dbReference type="GeneID" id="9579175"/>
    <dbReference type="KEGG" id="tve:TRV_07939"/>
    <dbReference type="HOGENOM" id="CLU_088982_0_0_1"/>
    <dbReference type="OrthoDB" id="5420368at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="216" mass="23855" checksum="1C16550B60BC91EA" modified="2010-05-18" version="1">MPVRWTSENDQMHTSATTLTNWSRKQLLVKFIETHDISVDPKKISEAWPAENEDARPTPRAITERIHKIRALAKATAAKNGTSAPTTPASRKHGAGGSKSSTKRSRTRGPKKDMSGENGSPHTPTPANNGGPVKKKTTDENLVSNGELEDMFTHRPLGKRVRTNPALPLGMIKYERDTDEEDAMKYESSVSEFAPADGDDKDDDDFMDDLVKDEIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLI5</accession>
    <accession>D4DEN0</accession>
    <name>SUB2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Subtilisin-like protease 2</fullName>
            <ecNumber>3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SUB2</name>
        <name type="ORF">TRV_08059/TRV_05599</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-"/>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017939.1">
        <property type="nucleotide sequence ID" value="XM_003017893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020323.1">
        <property type="nucleotide sequence ID" value="XM_003020277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLI5"/>
    <dbReference type="SMR" id="D4DLI5"/>
    <dbReference type="GlyCosmos" id="D4DLI5">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="tve:TRV_05599"/>
    <dbReference type="KEGG" id="tve:TRV_08059"/>
    <dbReference type="HOGENOM" id="CLU_011263_6_3_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397784" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397785" description="Subtilisin-like protease 2">
        <location>
            <begin position="123"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8" evidence="3">
        <location>
            <begin position="131"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="421" mass="45636" checksum="AEA0DFAA15271232" modified="2010-10-05" version="2" precursor="true">MQLLNFGLLLLPFVAGDLAPQPEPLLAGPSDVVPGQYIVTLKEGLTSAQIRDHKKWVSSVHRANLDSFAAGASGVETEGIMKHFHIHDLNMYSGGFDEKTVEDLSRNPYVKSVHPDQHVYLAKTVTQRQARWGLGYMSSKGKPVPLHSTLVDYSYDDKAGEGVWAYVLDTGINVNHIEFEGRAILGHNAIPNKPHTDEFGHGTYVAGIIAGKTYGVAKKANVVSAKAFDTGSSTYNYILETYDWIVRNITDSNRKNKAVINLSISGAKYQPFDDAVEKAFKAGITTVVAAGNDGKDAKNNTPASSPNAITVGAVRWENTRPSFSNYGKLVDIWAPGELIKSCWKGGNNATSTQSGTSAASPHVAGLVAYLMSIENLPSPSAVTARVLNLTIPNLVKDAKDSPNRVAYNGIQERKFTLPKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLS7</accession>
    <name>D4DLS7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_08151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000518">
        <property type="protein sequence ID" value="EFE37211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017856.1">
        <property type="nucleotide sequence ID" value="XM_003017810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLS7"/>
    <dbReference type="GeneID" id="9583750"/>
    <dbReference type="KEGG" id="tve:TRV_08151"/>
    <dbReference type="HOGENOM" id="CLU_011786_0_0_1"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="230"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="693" mass="74287" checksum="DD7EB87BA9DF9288" modified="2010-05-18" version="1">MPVISINGNDLNPENQGPVLRAFGLESEDASKSNYILIQTKELLEDEQEGELERLGVDIQEYVSQKTYLCCYKPNDLAAIRSLPFVTWANVYMDMFVVQSSMKSASVPNAVAGFAKAVPKSSRRRMVDVVLHHDVDPTSQEIQEALCMATRADTSSMNIGAKKVRMMVQDQHLDEVAAIDGVRSIHEVHAAVLFNNKAVPIIKGDANTSGDHPIGTAEAKDKASALPYEGEGQIVAVGDTGFDKGSTTDTHPAFKGRVKHLYALGRTDRSDDPDGHGTHVCGSVLGDGTSEKMGGKIQGTAPKATLVLQSLLDSQNGLGGIPDDLTKLFIQPYEEQDARIHTNSWGSNAPGRQLPYNVNSEEIDRFVWEHQDMVILFAAGNAGIDADQDGTIDKNQIGSQAAAKNCITVGASENDRPDIEKTYASWFPNKPFDTDRVADHPNGMAAFSSRGPTKEGRIKPDVVAPGTSILSTRSSKLLKPSTTFGTSADPEWFFNGGTSMATPLVAGGVALIREALVKSGNKSPSAALIKALLINGAVELPGQYVPSEAGPSPNSSSGYGRVNLKNSIPPAAKEGDNPASGYREGGPLTQGQTDSELVIKVPKDGGQTLKVTLVWTDPAGASLQNDLDLIVTAADGSERHGNMGDKKEFDRANNVEQVVWAKVPGGDVKVQVRAFHIFKREFAQRFAVAWSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZG2</accession>
    <name>D4CZG2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025564.1">
        <property type="nucleotide sequence ID" value="XM_003025518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZG2"/>
    <dbReference type="GeneID" id="9581802"/>
    <dbReference type="KEGG" id="tve:TRV_00204"/>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="352" mass="38717" checksum="A219CD3AC7160E25" modified="2010-05-18" version="1">MESKEFGTAIPTPGVDIPISSSTVNVRVIDTNTLVHLNPKLFWEPMIEGFTGFHAPSYCFLVSSGTRNAVFDLGIRTDWRNYAPKVVSVIEETTVITVGSDVASIIESDAGGLNLRREDIQAVIWSHNHFDHIGDMSVFPPTTDLVVGPGARDIALSGWPQNPDSFVLESDTSGRVVREISFDNCPSIGRFRAKDFFGNGSFYLLDAPGHAQGHLCALARTTADPPSFIFMGADACHHPGVLRPSSYLPLPVSVKQGEDKSTGHRVLVRDYARTRCPTKSIFEVSHGFLFPDRDAAMETVGKVQEFDALDNVFVIISHDVSLSGVIPLFPQTINSWKTDDLKGKTRWRFCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP1</accession>
    <name>D4CZP1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025521.1">
        <property type="nucleotide sequence ID" value="XM_003025475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP1"/>
    <dbReference type="GeneID" id="9581758"/>
    <dbReference type="KEGG" id="tve:TRV_00283"/>
    <dbReference type="HOGENOM" id="CLU_075696_1_1_1"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="222" mass="25087" checksum="F8A6D517E9B6FBD9" modified="2010-05-18" version="1">MKREERKSNGWEARDKQNFHKDWDRRVRVHFDQPGRKHRRREARLAKAAALAPRPVDKLRPIVRCPTIKYNSRVRAGRGFSLQELKEAGIPRKLAPTIGITVDHRRGNVSAESLSVNVARLKAYKARLILFPRKSGQFKKLDSSAEEIKAAKEGLVKTINSVLPVTNPARENAVSEIKKSDLPKGEENAYRKMRTARSDARLVGVRAKRAKAKAEEAAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP2</accession>
    <name>D4CZP2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025522.1">
        <property type="nucleotide sequence ID" value="XM_003025476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP2"/>
    <dbReference type="GeneID" id="9581759"/>
    <dbReference type="KEGG" id="tve:TRV_00284"/>
    <dbReference type="HOGENOM" id="CLU_029857_0_0_1"/>
    <dbReference type="OrthoDB" id="4160836at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="506" mass="55597" checksum="66E35C0F66BC9792" modified="2010-05-18" version="1">MTDCPGLTARYQGLVLGEVKAPDTLGEKRGSGSNSPTGSHDAGQGLSLSPPEADPPPRGTIAHFNGSPSQRSNVKRKQQPKKEGFYPIFKNKNTKATDPKRSAGESRPSIGIEPDDDLPKEIREKKKVRDSLREQLERLKEEVEFLEKEAGQLETTEHESVDESSLRRLIGLLLSKNPSCAPPPPKPPAPPPLSSMLSYLLPFTVQQSIPLSEPEPPPSPLPENPYAMKPLENSIPYLTVFAPLTLKTETVTSTVRNPSRALGVPSDIVQTYHFTLQPPGSFPASLYQIPLTLKTDPERQSVLSISISETDSKLPGPLEGWIASRLSNSLLDHDVSGLCWGICRYWEAAISRSKFWVKLQALSEKLEENPRYLEQAKKAYRKQGEADTSRSATPDMDGHQYATKDLVQHFERTSYRFSTSTGPNKLELLVSCPLTLDLWTSEPQLEPSICISGSSLKGTAASKIEKEAKRVFQAMIKRGNDGDVDVDIGSLVKAVEAVIVILFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZR8</accession>
    <name>D4CZR8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025548.1">
        <property type="nucleotide sequence ID" value="XM_003025502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZR8"/>
    <dbReference type="GeneID" id="9581785"/>
    <dbReference type="KEGG" id="tve:TRV_00310"/>
    <dbReference type="HOGENOM" id="CLU_035426_0_0_1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="47960" checksum="8669FECA1D4BB6C5" modified="2010-05-18" version="1">MQALARPSRENPSPTPLPLNSMNDDANCDGLNHEEVERAIDNLSKSGKTFGGLPRRDSMPMMMGRPYDFTDPRAMGPMAASRHHSIGDYDAMRPHSASNLQGFYAAQRFQGRPNETEQMIQAKRRLAAQRERELRNYHQEQQYNRSLLADISGDKSDRSMSPAAMTEESRRDLIARQHRALYGNDSALQTPSAGPGDDSHSQAAGTPTTGLPSGGRGASPRGVDPFLGGQPHADSQTQQATSGANVPCSVAPRTRSPPSTASPPSNTNPGSAATTTTYGGVFEPSQPPTSSPTGKGTTDSSPSRVGPIGSRPAQPQQQQQQSQQQHQPQQQQQQQQPPTNQSPNPSLSLRSTTPLPSPLSYGFSPNEDGGIGSSTAAAATSATGGANNGSNGNNGSGNGTGTDAGAGSATQSSSAAATSRSASGNNSTSQSMKESSPTVGLGWGWRGKNQLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZZ1</accession>
    <name>D4CZZ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025445.1">
        <property type="nucleotide sequence ID" value="XM_003025399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZZ1"/>
    <dbReference type="GeneID" id="9581671"/>
    <dbReference type="KEGG" id="tve:TRV_00385"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="357" mass="40447" checksum="1BFD506457F054DD" modified="2010-05-18" version="1">MVGIDIVEPAEIPVVDFQALSAGTLQERKTALKQLDDAFQSVGLIHLSNHSIGQDLVDEAFAWSKRFFDLPDDVKKLVCHPHDASDHRGWVAAGTTVSSQGVWDQEVIERMHKTGPVEKRESLETGDPYPSRIPNPNFIPNRILPEEIFPGFEAFTKKWWDACVEQELQLLRCLCEILDIPDKDFLGKQQNPDFNRSATGWNHYLSIPFQSLASGQSIRLNAHTDYGQLTLLFQDTTGGLEVEDNEAGIFRPVLPRPGMVIVQIADMLERQSNGRWKSSLHRVTTPHHLKHSDVGDSLLIERFSIGFFIQPDFDLVIKPLPGCEAKGRWSSLEWEDEITAGEWLTRRVALEYRPTDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZZ2</accession>
    <name>NSCA_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-reducing polyketide synthase nscA</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Conidial yellow pigment biosynthesis polyketide synthase nscA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Neosartoricin B biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nscA</name>
        <name type="ORF">TRV_00386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="ACS Synth. Biol." volume="2" first="629" last="634">
            <title>Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.</title>
            <authorList>
                <person name="Yin W.B."/>
                <person name="Chooi Y.H."/>
                <person name="Smith A.R."/>
                <person name="Cacho R.A."/>
                <person name="Hu Y."/>
                <person name="White T.C."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="23758576"/>
            <dbReference type="DOI" id="10.1021/sb400048b"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 11">Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="5">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025446.1">
        <property type="nucleotide sequence ID" value="XM_003025400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZZ2"/>
    <dbReference type="SMR" id="D4CZZ2"/>
    <dbReference type="GeneID" id="9581672"/>
    <dbReference type="KEGG" id="tve:TRV_00386"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF24">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE APTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437893" description="Non-reducing polyketide synthase nscA">
        <location>
            <begin position="1"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="413"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)" evidence="5">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="5">
        <location>
            <begin position="952"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Product template (PT) domain" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1703"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1719"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="7">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1564"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1779"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A0K0MCJ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="A1D8I9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="F2S6Z9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q5B0D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="23758576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="23758576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1819" mass="198944" checksum="08373DB37ACB387F" modified="2010-05-18" version="1">MDSTSRRVVFFSNEFPNDDLKELFRRLDQHSKDRRFRLLSIFLEESTAVLKDEVSKLPRPLKELVPPFDSVLGLVDVDFRQGPLGAAMESSMLTILELGLFIGYVSLLCLLDQVKMLTSLVYTSHYESEDTEWDLVPGESVLAGLSIGILAAAAVALSSSLADVAKTGAEAVRVSFRLGVYVADISTKLETPQSDGTLSSWAHVVTEMTEAGVQDELRQFNTDTHSPELTKVFISAADKTSVSVSGPPSRIKAAFQHSPVLRYSKSLPLPVYDGLCHASHLYTQSDIDSIINSAESVIVADRSVRLALLSSQTGKPFIAKTASELFLEIGTELLTGTIYLDNVTAGIVQHLQPQSKEISSWQIDSFRTSLVLRGIHSAVEAKLSGEQRQLIRRDLVNWVNKDFGPRQPRSHASSKLAIVGMACRLPGGANDLDLFWKLLEEGRDTLTTVPPDRFDLNTHYDPTGKTENATQTPYGNFIDRPGFFDAGFFNMSPREAEQTDPMQRLALVTAYEALEMAGVVPGRTPSTHPSRIGTFYGQASDDWRELNASQNISTYAVPGGERAFGNGRINYFFKFSGPSFNLDTACSSGLAAVQAACSALWAGEVDTAIAGGLNVITDPDNYCGLGNAHFLSKTGQCKVWDKDADGYCRADGIGSVVIKRLEDAEADNDNILAVVLGASTNHSAEAISITHPHAGAQKANYRQVLNQAGVNPIDVSYIELHGTGTQAGDAVESESVSDIFAPVTPRRRPDQRLYLGAVKSNIGHGEAAAGIASLLKALLVYQKNLIPMHIGIKSVINPTIPKDLERRNVGLAMQNTPWPRPAGKKRLAVVNSFGAHGGNTTLLLEDAPERVKIQGTEDRITHSILLSAKSKKSLQANMESLLSYLDQHPETSLADLAYTTSSRRMHHNMRFGTSVSCISGLQKVLRSQLDNVNFASEVRPVPNEAPSVILAFTSQGAYYHGMGRELFAEFPYFRAQVQQLDRLAQRLGFPSVVPVIENSIEDTPSSPILTQLSVVILEIALARFWSLLGVSISAVIGHSLGEYAALAVAGVISATDAIYLVGRRAQLVEERCAQGSHSMLSVRAPEDEIQKMLAAEPETASIAYEVSCCNTNQDTVIGGLTGEINDIRRTLEAKSIKCTILDVPYAFHTAQVNPILDDLETLAKAVPFKAPSIPVISPLLATVIYDVKSLNANYLRRATRETVDFAAAIEAAQDMGLVDSKTIWIDVGPHPICAGLVRSMIPSAPAMSSCRRNEDSIATISKSLVTLYLAGINPCWAEFFKPREREYSLLHLPKYRWNEIDYWIPYLGTWTLDKAHLKHGTKPTTPFSVSMSRPSALRTSLVHQITAETVEATTATLHTISDMQHPDFLEAIHGHTMNKCGVATSSIWSDMAFTVGEYLYRRLVPNTKDVHMNLTDVEVLHAQVASKTKGSVQPLVLRAHLDLSTSSMSLSWFNANGETGECAAESFATAMIRFEDPMAWRKEWARLAHLVRGRIEVLEQRASEGKASRLSKPLAYALFKNVVDYADRYRGMDSVVLDELEAMAEVTLVPERYGTWHTPPHWIDSVSHLAGLVMNGSDASNTRDYFFVTPGCDSFRLLKKLEPGAQYRSYVRMFPLPEDPNMHGGDVYILQGEEIVGMVGMIRIRRVPRLLMDRFFSPPTTTSVAGPVPPLSGETTKYHDIAQTAPALPAPTLPIVVPNPVASSTMASKAPEPAPLLATSSESSTPKESPIVTPAESEREDPVDNNMISQCLRLMARETGLEVEALTADASFVQLGVDSLMSLVLSEKFRAELGVEIKSSLFLECPTIGEMTAWIEEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0U1</accession>
    <name>D4D0U1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_00687</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025161.1">
        <property type="nucleotide sequence ID" value="XM_003025115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0U1"/>
    <dbReference type="GeneID" id="9580654"/>
    <dbReference type="KEGG" id="tve:TRV_00687"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="47"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE44550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="355" mass="38116" checksum="22737ED2FBA54EB8" modified="2010-05-18" version="1">MFRKGVRTFTSTALRAAETAAQMEARNTYGVGVSKAQGVVKGLTGGKAEFQNPGGSVKDRAALFVVKDAEERGLLKPGGTVVEGTAGNTGIGLAHVCRSRGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPENYNHQARRHAESLENAVWTNQFDNIANRRAHIETTGPEIWAQTEGKVDAFTCATGTGGTLAGVTRYLKTVSDGKVKSFLADPPGSVLYSYITSGGTLIERTGSSITEGIGQGRVTDNLQPDIGLVDGALNISDEKSIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGHTVVTMLCDGAYRYADRLFSDKWLKSKNLRGAIPRHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D120</accession>
    <name>D4D120_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025108.1">
        <property type="nucleotide sequence ID" value="XM_003025062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580600"/>
    <dbReference type="KEGG" id="tve:TRV_00766"/>
    <dbReference type="HOGENOM" id="CLU_006512_0_0_1"/>
    <dbReference type="OrthoDB" id="1883964at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1337" mass="146338" checksum="1C7CF9156D678AB9" modified="2010-05-18" version="1">MYGSQNYQQPPWQQQPPLPPPPPLPPAGDHSNKWHGGDQSQHVQPQSTYNPNTYGPMSGTPSIDHAQQDTSRWGVRYNQQFGHQHQPSVHDQHNAPPPLPPCPSSAFEFSQAQAQNAPQQQQQQQQWQQPVQTSQPYYPPSHGVTAPEYPPVAPPPPPQSWQQQPPPADHTSYVANQNAPPQPPPLPLAYQAEIQRPASEWPTAPVYSQHPPTHRYDPVSQQQQQQQPHQAPYQHDQHQYQQQQPQQPPYQHDQQEQQQQQYQYPPPETQQQQQQQPVVSPPAPPVAQNADNSGNSGYFQPASGETRNHLHSPPPDGNLQQPLPPTSQPLEAQTPAASLAPAISPLAAQATVATSTPPPATTAAASSATPTASTGASALGFGGPSDWEHFNSTGEEVDDTAEFGARTKSPINKANTFELPSDPSPQAPVTSSQAISQQPASVTSGQVSPEQPSRSGSHVISPVDASNQPAKNQSGSISGRLDSVSSIESNTPVDSKAIDGVIEAWSQPVISSSQHSSYSDAKPHQRSNTVSTFDYPRVTTPVSHIHASPQQSPMRTASRADVRPIQSIVTISDPYEDLDPWYESSLTRYVTMLRKEMETESEEEKYKLFSAFMHKESKLRAILYNVENVLDQQPSAKPEPAPAPNPVAASSSMAKDAPAPAPSQEVPSKISIPDPPTPGEQDDVISYSPGGLPRLASALTNQKKNNSVSDGLHRSASNPTRPQPTAGAASNQISNPNLGLSAHPNPSRSVSVPPESAVRPSTNTPPFTVEPPHAVYTPFRYNENSQKTSQSTAVSRPAYQGYSALRLASVESGRVMAQPSLQTPPAFPSERSVSRAEHDETFLGLIREKSVAYRSHRPGTSLSNRPALPKKGSPTITFEELQALVPGPPPRLESSSRVAIIGDEIEHFPEDFTFIEKTHEAWDNSATGRQAQVNAQRQARQEESETHIDSLFNDKEIGYSDINVLEDEFKQTEAQIQLNEERKEFDKYVEIVFSRVDERLASEIKRLQHLYNETSELLQPGGGKPSALGKFELSHAMRNAVDIFQKLELRHAKRVAAVLERERRRKKAERRYYVFLGETAALKQMEKEFTALEQKTLLDAAKARDERTNKLMDIFDDTSMRGIGENQRLLDDISAKINKFDTDLIRSTPSIVPTGGVKTLQNTLAFVKFLGANSESVLESFGVADRLLNNADYDVSVAEAKVADSSADIFRRLEEEKKKEDKKIEDDLQSRMSSIRTSHRAIIMNIEEVLECVEQAVASSEGSGAGASLTPPSGPSSRPQTTSSPGGIGSSNTPPALGVGVPTPHAANTLTAEEQQQERLKKALEEAKRRNAEKGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D140</accession>
    <name>D4D140_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025049.1">
        <property type="nucleotide sequence ID" value="XM_003025003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580541"/>
    <dbReference type="KEGG" id="tve:TRV_00787"/>
    <dbReference type="HOGENOM" id="CLU_000504_2_0_1"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25786">
        <property type="entry name" value="HEAT_GCN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1543"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1661"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1686"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="2002"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2672"/>
            <end position="2696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2713" mass="297389" checksum="DADD4F75DECCA6AE" modified="2010-05-18" version="1">MDEEQWDEVKKGSLIPLEPVVFSSSTSRRCQLLHQLQDTLTRDSQLPSQLYKKVLLLLFRTYPVYIDRESRHAAQSCAKAIFPSIPCTDLPAFAQLLRKESSNAAVAPANAFVLVEWCATLLQYLSTRLDDYSPLVLESVSAIGKALETCLGTSTKQSLKHSAIIITRRALRAVFSAESHGCNLVRDVVPSLIKEATSGFKNAPILGVICGVCARLPNRKDDLDAVKGDIFQFYSKEIVASRIPVPRHIHEGIRDLFTSFSTKEDLQKYVWPTVEKTILRSPEILLAGVLTSLASSVPVEIDLSEVFSSSICKQLLANIKSTNAVIRKGAIEALEAFIPRCSDEKSLLKVVDEVVTPLKAQKIPNVEQRALQAQVLRVVPCSSSASQAILTGLSAALLRESSEVALEPEIKSFCHHLTFLVSSRADVSTEYFTTVIKGCDDKRAGFRKTWLVNIGELFWNCDNSALQSSQMFRKECLHPVLTRLHKSFTEISANPIPSLQGGTISIANVLTALSFEKFWNEDNLPYPIEDIFPTALSVSPKPSFLLNPKIYTKLSSAEELKWALRALFAVTVQPGFETSDEQVKEAWAQAFIYLVCSLASPPKIRQLATGLLRQCYLKQPVLIGTTIISSIWKWLYYLDIADKEAAAVLSGAGKSNLSHVVRAITPSVLERDGHDSINKKDLESQCIELLVLCRPELVPGTSWINVSLKMGVDPGKLAIEYPDQCLNQILLVTGDPIRNNIAEARQAAWNAAADLGFVAPEVMIPKLVDQFREDLKPERISQFSATDIAIARHTGDTPFIDVLDTKAVSLPNKSAKDYDTLKWEEELRAEVAKKHGQKQKKLTADEQAKVKAQLEKESEIRDTVNCAEVMIKRGAGIIRSLANSPPTEADGWINPACSSLCKLAQLGGGVIVGDSISSALMACGNKASSRIGEMRPFVAIATLRAVGKTFLRSELETEPLGSKLYSWTLFILKVLLTLCTFAGLITRILYRLRILSEQRPLDGVSLGYILPLIFIVLENNGIEESKDDSGEQVLLALEFISFHTNSFSDARLPRIETLGHIINAMRKHTAHYKLVRDALSDLCRAMAANIQPDELEVLLRGSISREIPVRTAVLQSILSEIDLTDIDFSVYIWIAYHDNVAENAEIAREIWEENALDVDEQSPDLVIKHLANDDLSLRSAAALALAHACELCPSIFSDTLKKLESMYREQVHTKPVQTDSYGMPRKAEQADSWEIRSGIALSFGAMASGFSGDDIVSFFRFLIDEGPLIDRNASVRRQMAESGSAVITSRGREKVEELMSIFETALETSDKETEQSDWLNEAVIILYGSLAQHLVAGDNRIQKVTRKLMDALSTPSETVQLAVAQCLIPLIRLDGSDASHFVQELLDQLFTSKKYAARRGAAYGLAGLVRGKGILALRDFGIMSRLTEASENKKESNQRQGAVLAYELLAFVLGRVFEPYVIRIVPQLLTSFGDPSIDVRDACLDAAKACFASLSSFGVKQILPTLLDGLDDTQWRSKKGACDLLGAMAYLDPQQLALNLPDIIPPLTEVLNDSHKEVRNSANRSLQRFGDVISNPEVKSLVSILLKALSDPTKYTDEALDALIKISFVHYLDAPSLALVVRILERGLSDRSTTKRKAAQIIGSLAHLTERKDLISHLPILVAGLKTAVVDPVPTTRATASKALGSLIEKLGEDTLPDLIPSLMATLKSEAGAGDRMGSAQALAEVLAGLGTSRLEDTLPSLLQNVSSSKPTVREGFMTLFIFLPACFGNSFAAYLNRIIPPILVGLADEVESIRETSLRAGRLLVKNFSTRSIDLLLPELERGLANDNCRIRLSSVELIGDLLFNLTGATATDGEEEIDSAIQAGQSLLEVLGEERRNKVLSSLYICRCDTSGLVRSAAINVWKALVATPRTLKELVPTLSQVIIRRLGSSNMEQKVIAGNALGELIKKAGEGVLSTLLPELEEGLITSTDIDGRQGICLAVRELVVSSSDESLETYEKALISIVKTALVDTNDQVREAAAEAFDALQQALGKRIVDRVLPDLLHLLHNENDAEQALAALLTLLTEATRANIILPNLIPTLLTKPITGFNAKALASLSKVAGGGMNRRLPTILNTLMDEIISTEDSGLKSEVSEAFDTVLDSVDEFDGLNVAMNVMLALMKHDDHRRRSSAAMHLATFFSNTEMDISRFYPELIRVLLISFDDRDKEVVKAAWDGLNQLTKSMKKEEMEVLVNPARQVLRQVGVPGSNLAGFSLPKGIGAILPIFLQGLLNGNIEQRTQSALAIGDIIDRTSPESLKAFVTQITGPLIRVVSERSVNIKCAIFLALDKLLEKIPLFVKPFLPQLQRTFARGLADTSSETLRTRAAKGLGILITLTPRVDPLVAELITGSKTTDPGVKNAMLRALHDVVDKAGTNMSEASRQAVFGLVDNDSVDDGTLSPRISAMALLSTCDNDYERQACWSIDQIAAHTHCYSPYQVGILRAYLDETETNVGIRNRILATQLTHQSILRLNAILVESPALLNENFRSEVFISDNGVLAAGKYLLSSHMDRKPEDEQEVFEALAGVVQPGKPVDTRRLTLVVLRTVARENEEMIARYRSLVVPPVFGGVRDTVIPVKLAAEAAFLAIFSVVESEGEVFEEYMKGPGAELPAGPKRSMQDYFKRVALRLGGQARERREAEGGQGGLGLSSDEVEDEKEVWSVGKVDLGESFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D182</accession>
    <name>D4D182_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025025.1">
        <property type="nucleotide sequence ID" value="XM_003024979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D182"/>
    <dbReference type="GeneID" id="9580517"/>
    <dbReference type="KEGG" id="tve:TRV_00830"/>
    <dbReference type="HOGENOM" id="CLU_007427_2_0_1"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="572" mass="63972" checksum="804F92B8C4CBB83C" modified="2010-05-18" version="1">MEPGLHEPASGGSTTFLGRSEYIRGEVPINEDRAKAYPAVATESLMEEDIQILQLQHAFDLPPRAVRDGLIDTFMKRCAPWMPIVERSWLMERRDSQLSILLLQAVFLAASRVSSAPAVTAYASSNEFYRRAKALFWSGYEKNTITVITAVCILHWYNPEGPEHVSINTSGFWSRIGVGLAYQIGLHKEPPPGREAPLRRRLWWTLYARDCLISASHGRPRAINTEDNDVRPLTPEDFYGCGADDALFLAHVEVSSLLGDVTQACCRRTLTRPKRTAIENAIYRWSRELPEQLRLFQRVLPPEGSTASKLVLMPYHFEARQLHVTYFVVLAILYRASSPGTIPSAAAILASSFVAGIFEDFLARDEIRFLGPIFTFYLLASGVGLASCYSYPHLWERAQQDLRIICSSLRELSKRWPSAIGSLKALQSMIDETAKAARPSERPQPTPLTSDQQATFCGFGTDLCRLGDVMLAHYPHDIVDSGRQEDDQYARTVSDMMTAGILAELKTPMDSASAPVDEYLPLASVIDHNTQLAFGVEEPTSIIPDEVLYGQYEGIGNWLLRGWDCTAEVPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D215</accession>
    <name>D4D215_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024710.1">
        <property type="nucleotide sequence ID" value="XM_003024664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D215"/>
    <dbReference type="GeneID" id="9582885"/>
    <dbReference type="KEGG" id="tve:TRV_01117"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="4172289at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="351" mass="39890" checksum="6B28864110C15684" modified="2010-05-18" version="1">MSPRLPPPEENGYGGSETNHNISQRRYAALKVYICSAGAEQECNVLRHLESLKSSHPGKAKVRTMLDAFTADGPSGRHQCLVHEPLLTSISHLQASLPNQRLTEQVLKLLLKELLVTLDYLHTEAQVIHTADYLQDIQSKNIMIGTNKPSLFEEWKVQAVQGPTARKNVPGHVVYRSRRYNIEEGRGAWGLPLLSDFGQARIGPGDHEGTIQPTLYRAPEVVLGVKWDSKVDIWNLGALIWELFENYYMFQDRGSDGEYSEAHLLASMIALLGPPPSQFLKRSDKSLRFWDESGNWRGLAEIADVSFEESELYLEGQNKDIFIQFVRKMVRWEPNERQTARELLNDPWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2J3</accession>
    <name>D4D2J3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024586.1">
        <property type="nucleotide sequence ID" value="XM_003024540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2J3"/>
    <dbReference type="GeneID" id="9579910"/>
    <dbReference type="KEGG" id="tve:TRV_01298"/>
    <dbReference type="HOGENOM" id="CLU_2086543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="117" mass="13532" checksum="0B35D2DE2EAE439B" modified="2010-05-18" version="1">MDGTDGKRQVDQWGKEGRKEKKRNKMKQYRNTARQAGREKKKPGPGEEEEEKEETSRRSIHWKGADGEEKGGDIKRCITSSQCIKISNQSKDQSKPDQTIPIAKVKRRKKTKKEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L8</accession>
    <name>D4D2L8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024493.1">
        <property type="nucleotide sequence ID" value="XM_003024447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L8"/>
    <dbReference type="GeneID" id="9579715"/>
    <dbReference type="KEGG" id="tve:TRV_01323"/>
    <dbReference type="HOGENOM" id="CLU_044218_0_0_1"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="498" mass="55948" checksum="B8E18F227D5F424F" modified="2010-05-18" version="1">MEPDPLLDNRFERLRVKDEVYGGPKLSTNQGMCKLYQHTLGWKHNIKSLGPAKISEVKCVASYNWVRKNRVTMLIPGAPPVWHPSHSICDKAETEGISQNDVGTTYKWLPGKSPEDAYRVVYQNDGKGGWHGHPLEPMIYAAKLMDPAFELNKFDFVIDAAAIEFMLAFIQFEPNDHNLKVELVNRTVFIASEESERYPCSYQPLVDDALTWEDCVKDSISHQRVLSYVFGGHRILIRCSTHGYLPGSTGEAAESKEGEDPVVEKENGSDAPRFGASAKGFPVAYRCGKIIPQEAIFDFKGNEKGAPRDSPSEGDIGWMWIRQVSKIMTVETGGAYNNAKVQDTTSLLRQWEDKNRPDLVQLADLLSKMRHYANESRSRGLLISRVICPKPEFMSVIESKTPRTISLAVLNYDPTSRKEPSSTNKERKECNTGTGSLPKCTIKKGKAEPEFYTAAGISKSSSLESIALTDWEFLDETECDTEWVEVESRRSKPKKLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2M4</accession>
    <name>D4D2M4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024499.1">
        <property type="nucleotide sequence ID" value="XM_003024453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2M4"/>
    <dbReference type="GeneID" id="9579722"/>
    <dbReference type="KEGG" id="tve:TRV_01330"/>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57691" checksum="7006ABDAC563F410" modified="2010-05-18" version="1">MKRQYLPVDALQAWARLNSVTFHGVEIKQPPYDGEDIDKGSAVLAIGSPDSQEPILDEPGLEPEILMKVPPDLILSQERVETHAKSDKHLKDVLDAVGDFGKGSRGAMMIFLLLQITHSSVGKGEQVGISSPWTEYIKFFPAVYELPTFYTLEERELLRGTSLEPALDTKIQSLAREFDHLRDSTFNIPWCQREWWHPETGQLEFDDWKVVDAMYRSRAMELPGTGNAMVPCIDMANHVAGNKTVALYETDIDGNAVLQLRWGQRLKEGEEVTITYGDRKGASEMIFSYGFLDQGLKSAQQLLLDLDIPDDDPLKPPKRAVCEDGPGVRIFDAGDDHDQETAWHSDFVWWICVNEEDGLEFRVLQTNDGGRDLRVFWKKEEITGARKLGQFLSEDPRWDIFQLRAVVIIQERVANQLTLLQAATEYVRGLADKVDDVLIRRSVWDTAMKFRSLEENLLTKSNRDLDEKVGSSPHFTYSFLKLELLESRTVQAYLNSQCSSADIDEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2P6</accession>
    <name>D4D2P6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024521.1">
        <property type="nucleotide sequence ID" value="XM_003024475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2P6"/>
    <dbReference type="GeneID" id="9579744"/>
    <dbReference type="KEGG" id="tve:TRV_01352"/>
    <dbReference type="HOGENOM" id="CLU_105624_2_0_1"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18755" checksum="73CA9239208C07F5" modified="2010-05-18" version="1">MKNRRTKKIFKPPRQYNNSAGYLPLCGLSQSHTSTVVTMAPTTARSAKGRQQKVTKKYIINASQPANDKIFDVSAFEKFLHDRIKVEGRVGNLGESVQISQVGDGKIEVITHIPFSGRYLKYLTKKFLKKQQLRDWLRVVSASKGVYELRFYNIVQDEAEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2V7</accession>
    <name>D4D2V7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024450.1">
        <property type="nucleotide sequence ID" value="XM_003024404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2V7"/>
    <dbReference type="GeneID" id="9579672"/>
    <dbReference type="KEGG" id="tve:TRV_01413"/>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="217" mass="25491" checksum="45238B9EA51A1A50" modified="2010-05-18" version="1">MAADDDLDALDSLNSLEKEASEFTKDAEIDRIRKAFQLDAYAVLDLQPGVPDSDIKVQYRKKSLLIHPDKTSNPAAPDAFDRLKKAQTALLDEKQRAHLDECIADARRLLIREHKYTLDSPELKTEAFKEEWRKKTVFVLLEEEARRRRQLKGRMQEEGREKKREEEELEARKRKRDEEKAWEESRDTRIGSWRDWQKGRKGGDKEGKKKKKMKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D312</accession>
    <name>D4D312_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024402.1">
        <property type="nucleotide sequence ID" value="XM_003024356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D312"/>
    <dbReference type="GeneID" id="9579624"/>
    <dbReference type="KEGG" id="tve:TRV_01469"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002203">
        <property type="entry name" value="ATP-dependent RNA helicase (Hrh1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="107"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="366"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="787" mass="86367" checksum="26D6613F65A89420" modified="2010-05-18" version="1">MDSLDSNTGNGEDKAVSASKRARKRKRGNRNNDDENGIKKLRISANGVESEQTSRKMIQNSTVTHERNISNSTGHSKNGTANLKEKARVLLETRQKLPIFAHADEIRAHLRRTDVMLLVGETGSGKSTQVPQFLIDEHWCRPKSVKIPSSGNKQTATVGGCIAITQPRRVAAVSLARRVAEEVGCPLGSSSPASKVGYAVRFDTSVSPSTRIKFMTDGMLLQEMLSDPWLTKYSAIVVDEVHERGINVDLLLGFLRDIATGCKEGRGGVPLKIVVMSATADMESLLSFFTDGYTQTSNAPLESMKEDDAGSNAQKANASRLSAKGKEIQRKPDQISVCHIKGRQFPVTTIYSPVPVPDFVDAALKTVFQIHYKEPLPGDILVFLTGQETVENLEYLVNDYASTMDKELPKVLAVPLFAALPQVAQQRVFLPTPPRTRKVILATNIAETSVTVPGVRYVIDCGKAKTKQFRTRLGLDSLLVKPISKSAAIQRKGRAGREAPGQCYRLYPEKEYLALPETNTPEILRCDVSQAILTMKARGVDDIIGFPFLTPPPRDAIEKALLQLFNINALDETGKISPIGSRIAKLPLTAPLGRVLLAGAEKGPRCLRDVIDIISCLSVENIFLNTSSEEKKEQADLARRDLYRREGDHLTMLATVRAYAAENADRRAWADRHLVSHRAMQAVMSKLFGDTSFKDDDSTPLGNEDSVPILTSFLTGFATNTARLFPDGSYRTLVGNQTVAIHPSSVLFGRKVEAIMYNEFVFTTRSYARGVSAVQMNWIGEVLAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D369</accession>
    <name>D4D369_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024328.1">
        <property type="nucleotide sequence ID" value="XM_003024282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D369"/>
    <dbReference type="GeneID" id="9579454"/>
    <dbReference type="KEGG" id="tve:TRV_01527"/>
    <dbReference type="HOGENOM" id="CLU_005053_2_1_1"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="365"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="992" mass="109114" checksum="D0536CEDE137F8EB" modified="2010-05-18" version="1">MLATPSNNPVRRLSSFFSLGSPKPDDKRSPTKSPHLQSSRSSSLQTPPLRDQQLAEETQALSLNPRNVSAPVLGENAHQSYTPPPRLSSLNPDLAGPGSPDTHSRSQSWSDAVPRFSKSGSRPGSGLGVSGVNVNPSPATISKSKKGAKSKLSGSDASNGKRAWIAGTENDIPYDISTLLAGERVADLWDDAGDTYVYLFPQNSGRPPSFKVDSAIFSASASLTLLARGNPSPPQSTRGGQGRSRDPNSSSPPLSAQNGSSYDEGSDGQSQDGFLDDESPELHLYMPVPLTGDLPCGREQPVLSADDVDMLVLFRNLFAFLIGQALIATPRTPSIFNIFMEVSGLLDRFGFTNLDQSTFGETATSSFGCYCDELDLIDVRASRERALDAIILGERMKYLPLYQEGFTHGVAVLDDLKKFETKYNLVSAVTRKRLERGYLDLDNRIRTCAVKIDEFEFPSLFAGIANSNVANEAKVIRFKNWKNAYLSYRKNVMNYYRARFGSWPPKASKKTQFQESGLNRLVLRELYQDFCDLYDMLADRTDLTTRSADMTTSVFKAEDSNSTSQALRQIMSEYDRSTPPVQPPIPFDIPRLPSIHSIRRKLDPKREAKERSKRLTTGEVNEILVSSYNHASMKPTPFLENFMNYERRVGHGKCADELADMRCAQWLFMYAVIQSLPMLVVDAPDLRCTHGVEYFLCIPPWGGSPWCASDPKNGKKWFGVAGGSGVVNLPSDVVANGVDAVYRRSHCWQVALKWADDGQLNSSVMLDPASQQPEEPQQPPLPPPVPQSQPQSPQQQYQAYPQYPPPPQQYPQQPPYPAPQYPPPPPQQQQYQPYAQPYQQPQYPPQHYQHYQHPSLSISTPDQSTAGSLPPSGTPTAYPPPNQAQNFYPFPYPPPLSSTGSSSDRQPTPLLTPGDTTPPNLPMLNLQPPSASFGRGAGTPGNRSSIYMGLEALPLPAGVSPVDTSGRSSTHNPDASFDHILQGVSQPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3C3</accession>
    <name>D4D3C3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024232.1">
        <property type="nucleotide sequence ID" value="XM_003024186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3C3"/>
    <dbReference type="GeneID" id="9579270"/>
    <dbReference type="KEGG" id="tve:TRV_01582"/>
    <dbReference type="HOGENOM" id="CLU_039950_0_0_1"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="386" mass="43539" checksum="4A2097F2A4CCF70C" modified="2010-05-18" version="1">MKICVERQLERRYISTSEVKRPDVATPGGLVQSPVVLRRAQKQTSSASSKVIERSKEWDTDSSLIRNPWAIALASPPRLCHATMSRLPTELMIDFGLVQHPETSALWLLPTSLLENELNEMEIDPNSKVTADDNNTPAVGEIRMDDSTAKMRKRRAAFPSVRVTNSGTLFDMLSNPKFSNISKGLIPPSWKLPQGPLTKSSMQTLVWRGDMSDYALKAMRKEILRRLKKILHVTPKIEKQRRRDTWTPLSIAGHPITQSNLESSLKQLPELRDIRSGMVLVLRSSHHSTEVNSNPDCNATSSTGPENTTFDLAELPVHESQVPVFDLTKMLSEGELQEIRQLGKVFQGDALYFIPASRKSALFALDLWRLKSFLMERNEEGSSFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3E9</accession>
    <name>D4D3E9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024258.1">
        <property type="nucleotide sequence ID" value="XM_003024212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3E9"/>
    <dbReference type="GeneID" id="9579378"/>
    <dbReference type="KEGG" id="tve:TRV_01609"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="32360" checksum="A424ED7C47A5DEA6" modified="2010-05-18" version="1">MDEFNNTDTDSDYTSFWRDWFISSRGNEYFCEIDEEYLTDRFNLTGLNTEVQYYQYALDMVTDLFDLDADEDLREQIEKSARHLYGLVHARYIVTTRGLAKMVHSPQRSLQVEKYKNADFGKCPRVMCEQHPLLPMGQSDIPGQKPVKLYCAKCEDIYNPKSSRHAAVDGAYFGSSFHNVLFQVYPDLIPDKSRQRYEPRVFGFRVHACAALARWQDRKQEELLDRLRELDMESPFIEDREGDEDEDELEEDDEEEEEEEDEGGDSIMKDESMPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3F1</accession>
    <name>D4D3F1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024260.1">
        <property type="nucleotide sequence ID" value="XM_003024214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3F1"/>
    <dbReference type="GeneID" id="9579380"/>
    <dbReference type="KEGG" id="tve:TRV_01611"/>
    <dbReference type="HOGENOM" id="CLU_3242461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="43" mass="5099" checksum="4631DEE6FC7C9626" modified="2010-05-18" version="1">MTLRPFSFILSLCKSLLRRDGRSGAEKKKKKKKHKNKRAFFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3V3</accession>
    <name>D4D3V3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024096.1">
        <property type="nucleotide sequence ID" value="XM_003024050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3V3"/>
    <dbReference type="GeneID" id="9577084"/>
    <dbReference type="KEGG" id="tve:TRV_01765"/>
    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="361"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="654"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="741"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120333" checksum="6FE29EC3DB3E7C52" modified="2010-05-18" version="1">MHKISNFTGQARHGWERMTPNFGMSRPQQDAPNSQYRRPQGPGQAPPQQPHHQQHPSQQHQQLPLQQQQQQQQQQQQSQQLPPHHQPSQSASPNPTSGASTPAGTVVSAAPSVEPQLINISFNIPFSSNLPGPDPADILHSSPNAFQRWTFPEGTPEGTPTHRLPVHTQHVDSLRKLCRQMSESSGGRIEATVTSSEPKMASPMQRRHHGLVTNVCISGEAEMVQQMKARIYRETPIVLRSLTIDVDVDLLLQKETDSIRKIVLEHIDILAGYTGADIFLLSPKIVDADNALSSSYGYSADGGLNRRFRIAIYSDAESAEHAKSRVLIMIDQIVRCTPSASFLFQWPFFSDLNIQLKRRVDAVRLELSTHFLVCGRTRKNIKMIEATTNTAIYFPPPFPRVYGYMPPGATRRCEDEVYITGNSQEDINLVKQKLRDLVAVLKIYVKEAIIHPEKVDSIILERLDKIQKVMEANGCFVLLPQLGSGTSSIRVQGTDVLHVERTIRELMNVAGQFYGATWWLMADNPQMRTPSPADVRTMLSDICANSGADVTFDNLTFHIHGSDDSVKAAMMVIHQIPFVKRSPHQMKVKIELANEHKEFVSGKKNGKINKIMSQIVGNVQIIFDGFNEYNFYIDVCANDYEAVTQGLHLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRVMKKYSVFVKFSNAMDRGGAGKDDDDGRVENVICRTPARNAQNLELVKQEIMDMVEKVDAEFVSETVVVNRLYHRNLVARIKDIDELEKKWNCKIDFPSTETASDLVTISGPEYQVPQAVDAFLGMVPESHSMVFGVSDELRAFFLTPEFSEVICRNLREQYEIELSLGTATRQAIVNPENAEPLSEDTLDMNFTRNNAGGIKDAVDFLISRLVPHGLDATTVKGSIPRPKSDSFEDSLPFFDSKLLHHAPPPLVADSPIRASFATDDSADRGSIFGRLRKPGSIASFSSLIGRKNQSSSPGSLFKHASSNASKASLVSMESRDSGYRNPWNDSGVNLAKEDLLTPSGNGWPTRFDNKFPFGTGGSGSVSGGDMTPRHDLRASFDSGRPSTSNSYSAPIGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4L2</accession>
    <name>D4D4L2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023832.1">
        <property type="nucleotide sequence ID" value="XM_003023786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4L2"/>
    <dbReference type="GeneID" id="9582407"/>
    <dbReference type="KEGG" id="tve:TRV_02029"/>
    <dbReference type="HOGENOM" id="CLU_064339_2_1_1"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="32741" checksum="05ECD404F38FE45B" modified="2010-05-18" version="1">MATEASDLTPLLEQLEDSIDDIEEVLEPLLERGLTATAQKLPLLDKAKLHVLLSYSIESLIFSNFLLPAYLRLNDVDAKEHPVFRELNRVRQYHEKIKTLEAPPEKRTMTLDTQAAGRFIKHGLAGNDKYDLERAEREAKEKAMAQLRAAQLAKMKAKVAATVPQKRSVEESEMSGRDSTAVSTPEPKKSRTTDPEDDDEEDDEEEEDEGEEDGEVEEEESAEDDKQGGEVKEEAFIKLPAVETSKKNKKKLSKAERKAMHGKNGNNAAKKRHKRKNKKDKKAGAAQPPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4M5</accession>
    <name>D4D4M5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023845.1">
        <property type="nucleotide sequence ID" value="XM_003023799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4M5"/>
    <dbReference type="GeneID" id="9582457"/>
    <dbReference type="KEGG" id="tve:TRV_02042"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_2_1"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="312" mass="34881" checksum="C5ACE1B4559A5F39" modified="2010-05-18" version="1">MMELVEETDLHGALPLVSRGKVRDIYQVDDRTLLFISTDRISAYDVLMQNGIPNKGQILTSLTVYWLKFLTGALPSLRTHLVSLEMPGDMPQACRDYVKNRSMVVRKLKVFPVEAIVRGYLAGSAWTEYQKTGTVHGIPLPAGLVESDKIPGGPLFTPSTKAEQGGHDENIHPDKDIDILTGEVAADIVGAAYAEDIKAVSIRLYELASFHALQRGIIIADTKFEFGHDEVTNEIVLIDEVLTPDSSRFWALDTYQPGKPQDSFDKQFLRDWLTKEGLRGKDGTIMPKEIVQKTEAKYIEAFERITGETFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4N1</accession>
    <name>D4D4N1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">I/LWEQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023851.1">
        <property type="nucleotide sequence ID" value="XM_003023805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4N1"/>
    <dbReference type="GeneID" id="9582463"/>
    <dbReference type="KEGG" id="tve:TRV_02048"/>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="718"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="216"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="920"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="960" mass="109173" checksum="A0449E68CF353081" modified="2010-05-18" version="1">MLCYWRNAILRGERRLIQVTGYGPLIREYVFFLESKLAFHRQHPEFNGLFEYEEYISLKSINDPNEGYETITDLMTLQDQIDTFQKLIFSHFRGSANNECRISALVPLVQESYGIYKFITSMLRAMHSTTGDEDALEPLRGRYDAQYYRLVRFYYECSNLRYLTSLISVPKLAPQPPNLLAGEEDKPSLPKRPTNEPEREPTPPPKSTIPDAEPINDFWSTEAKRQQEEYEAEQRRLQSQWEEQQRQQMLAQQQAQREFEEQQRLQAEQQRLAQEQLMANQYQQQTQGRLAELEQENLNARAQYERDQLMLQQYDKRVKDLEEQLNQINSNFSSQNSSKDDLIRSLQEQLNTWRTKYEALAKLYSQLRQEHLDLLQTTKSLKLKAASAQEAIDKKERLEREMKTKNLELADMIRERDRALHEKDRLTGGNREELEKLKRELRMAIERAENAERAKGSEISAMLSKYNREMADLEEALRSKTRALEEFQSSRGDLNADHEIMLREKDEEIEIYKSGMEQALTELEELKLSQGDADKALDSQIDDVLIGSISKVNDIIDSVLQSGVQRVDDALYELDSTMQAGNQNASLSYVLSQIEKASASATEFSTAFNNFIADGPNSEHAEIIRTVSVFSGSIADVLSNTKGLTRFATDDKKADQLVGAARSPAESTMTFFRALQSFRLQGLEPTQKTDVVINNNHEVLMNLQKLSKLVDTFAPKSNKLTGAGDLGDIVDRELTNAANAIEAAAQRLAKLKKKPRDGYSTYELRIHDSILEASIAVTNAIAELIKAATASQQEIVKEGRGSSSRTAFYKKNNRWTEGLISAAKAVATSTNTLIETADGVISGRNSPEQLIVASNDVAASTAQLVAASRVKATFMSKTQDRLETASKAVGSACRSLVRQVQDIIAEKNRNETETIDYTKLSGHEFKVREMEQQVEILQLENALSQARKQLGEMRKISYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V2</accession>
    <name>D4D4V2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023732.1">
        <property type="nucleotide sequence ID" value="XM_003023686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V2"/>
    <dbReference type="GeneID" id="9582300"/>
    <dbReference type="KEGG" id="tve:TRV_02119"/>
    <dbReference type="HOGENOM" id="CLU_041563_0_0_1"/>
    <dbReference type="OrthoDB" id="4171594at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="37462" checksum="0033A3EB4411141E" modified="2010-05-18" version="1">MPPPLRVLTRGSVLVGKRGQRYVLLDPLVQRKGKQCNVWSAAKQDDPMHQFVLKKPDDEDGPGWPDFTREMEMQKLLYKSGYIRRMVDVIPPPSDTEPPIMILEAFEKSLWTARLRRPFSLGEIRSVMRSIAIGLSTIHHNNIVYIDLKMENILVNGFDNETPGSGEHLVTKIADLGMMRPPSQGPISAITYRSPEVYFKKPWTTATDIWSWGIVYLHLLQAHINFEEPGIFDSLKVEGTLIDKENTIRAAMGQEFDLHTIEYYNSDPDTRQLLPPKDKTRTELDHWVVKLINKDIPEKDIQTVHVALNPVPELRPSALELLEYGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V5</accession>
    <name>D4D4V5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023735.1">
        <property type="nucleotide sequence ID" value="XM_003023689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V5"/>
    <dbReference type="GeneID" id="9582270"/>
    <dbReference type="KEGG" id="tve:TRV_02122"/>
    <dbReference type="HOGENOM" id="CLU_2051362_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="120" mass="13613" checksum="159E75BFC11FED3C" modified="2010-05-18" version="1">MDGYKNIPGCTKNLDPRLFQAFAGDKACLCQAIQSVYRKIGRLPDVTAAKYITKRNPTLYTLLPRDTSAFSNLQHFSFNGAHNVAHIVVPKECFANHNVYIYYRLFHFGCRQAKSVRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4W7</accession>
    <name>D4D4W7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023747.1">
        <property type="nucleotide sequence ID" value="XM_003023701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4W7"/>
    <dbReference type="GeneID" id="9582282"/>
    <dbReference type="KEGG" id="tve:TRV_02134"/>
    <dbReference type="HOGENOM" id="CLU_2656221_0_0_1"/>
    <dbReference type="OrthoDB" id="4168528at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="76" mass="7870" checksum="83E9315F3C13DEDB" modified="2010-05-18" version="1">MFTNTPNGTFLVLAPQSHTAAQLNMATSKPAAADAPVDIDTQAADVEAPGKTKRSDSNPFIPAIGAKGFTFLRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4X4</accession>
    <name>D4D4X4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000114">
        <property type="protein sequence ID" value="EFE43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023708.1">
        <property type="nucleotide sequence ID" value="XM_003023662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4X4"/>
    <dbReference type="GeneID" id="9582256"/>
    <dbReference type="KEGG" id="tve:TRV_02141"/>
    <dbReference type="HOGENOM" id="CLU_401803_0_0_1"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="3">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="552"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="74668" checksum="3C43B6C97CA5B956" modified="2010-05-18" version="1">MALVTYSDSEGDSDTETKPTEQPKAPRQAPTSSSKPAFKPLVDRGNPRKILVNLSEAKPSEGADSGQDKEDGPARKRLRTEGGGLFSGFNDMLPAPKRSAQKPVDKSQAGVKKSKPFTLKTSAEPGFDRSERSDNFNMSCDEFGKPSSGQDTAAQTPSEEASRTPVPEPVFEKKGNAMMFKPLSVARNKPKRKMTAAAQPVSTSKAQAENPQPPVQPEARPETKPKVSLFGLSSGAESIPSTDITAQDEPYEAILYSTSSEPSGALETKVPDDSIVTTTAAYNNSPAPAASSGPQDLASVASDLNLSKSQMRQLLGRDLKGASSKVINFNTDEEYKSNSAYLANTSEAELAAQQHRPVRTVAPGKHSLHQLVNAVASQGDALEESFATGKRNKKEASAKPCCVADPRSQSRCKMPRDRAAYRNVRLYDASTGTLIGGFYQNGAITEENLIWILSNVLLATQDANTWTIQQRTSGETVTPSSEPVRPGDYDIHSTGTGFWLLKPPVNINTELNIYIGPIQVTDEPWFARIASHSISGGEDQFRDGVRARDGRCVISGRINRGAEWDDWAGLESAHVFPLEKESLWVQLGYGRWITNMDDTSAEHKINSVQNGLLMSAHFHRRFDQYLFSINPDAVLANMRGAGEPIFESDFPPGSDMMATLREELYGKERFEMELESRLRPGTMNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Z1</accession>
    <name>MCPB_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable carboxypeptidase 2</fullName>
            <ecNumber>3.4.17.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase M14B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Carboxypeptidase MCPB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MCPB</name>
        <name type="ORF">TRV_02159</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EFE43078" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.17.-"/>
    <dbReference type="EMBL" id="ACYE01000116">
        <property type="protein sequence ID" value="EFE43078.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023696.1">
        <property type="nucleotide sequence ID" value="XM_003023650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Z1"/>
    <dbReference type="SMR" id="D4D4Z1"/>
    <dbReference type="GlyCosmos" id="D4D4Z1">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9582248"/>
    <dbReference type="KEGG" id="tve:TRV_02159"/>
    <dbReference type="HOGENOM" id="CLU_026103_1_0_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06242">
        <property type="entry name" value="M14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF83">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397763" description="Probable carboxypeptidase 2">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="3">
        <location>
            <begin position="71"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="518" mass="57640" checksum="B1BDE11346AF79EB" modified="2010-10-05" version="2" precursor="true">MVAYHLLTLISLGLGSHCASALQYGYNQLSTHKDSAVVAGAFPAINGTHLQSPAFTSPGTVPRGFSDGTSGPTRDETMEGFMRRLARSNSWMAYHEADFKSEEGRKFPYMYLSASNSSVENPSSRKLRVWLQGGVHGNEPAGDQSMLALLGDLAANQKWAAKLLEKMDILVLPRYNPDGVFYFQRYLATNFDPNRDHIKLARQQTRDIKELFARFSPHIATDMHEFTAGRTFGPKRDIIYAADALFSAAKNLNIDEGIRQLSEELFAKRMGKDIEAAGLRWDPYITLGESSSSKLLLLEAGTDAKIGRNAMGLSQCVVFLCETRGIGIAGQHFERRTLSGLVMAKSILQTAVDNFDEVYNTIERGIRRFTNSRNDIVLSDKSPVMERTFGMLNITDASLFDYPIDFATTTPAEAVLTRSRPRAYLIPPSWPDIVKRLEVFGVKADKLPYSYVGPVEALNVTSVTFDKEYYEGVVTTTVETKLVERNIRLPAGSYLVKTNQKNAALAFVSLEVRTLYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5D6</accession>
    <name>D4D5D6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin C-terminal hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023559.1">
        <property type="nucleotide sequence ID" value="XM_003023513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5D6"/>
    <dbReference type="GeneID" id="9577031"/>
    <dbReference type="KEGG" id="tve:TRV_02306"/>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000055">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000125">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="364"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="682"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120596" checksum="E803635C9A1541C1" modified="2010-05-18" version="1">MVEPAEPIWGAGDGAPVPGAGRPPYPSMKELQNMAACLNLGEDPSLNELLHISEDAISRSKTLAQRGKYDSALVYYLRASDITVNMIPRHPDFTYMKQNHPRWADQFARLMMLVDSQHKTMEDIKRKITESNNAAGHSRSTSTPSSAPLRMPSPTNFHRQPLNTTSHSSAGSRPASESIPAQDPLAQRLAGLRNHRHQGSSPSNEGTNGSSYSTISPNGNYSTYRSQLHSQAHSGQRSPVPSKPLGPREMNPSVPTVPPKVPISGVDAPPPRYPSPAYNPMWTVPSIPTPNPPRTSVESIRNTIYKQTNTGATNSNSSLNTSTDNPYRSQTPNGIRPEADSGNRSPDIYVGPTITATKLVEYIRKYDVLLIDVRSRDQYDAGHIYAKSILCIEPVVLKENISAEELEDRLIISPDTEQSLFNRRNEFDLIVYYDQSTVEPTYLIGSPAGSAVPHLRALYDTLYEFNFYKPLKGGRPPALLVGGLDAWVDLVGPQSLATSQTSAILSSVRARRQAPDSSQPLRRNPTVSANSSWEVRKRRLRDYKPLNPEEERAWLEKAKDEEIDTSYVAEEGDITEEPEDIDGSTLRQTASFVHSYEDFLRRFPEPNDIRESMVHAGNAVQFPLYDAAAVPAPSRPPPAIPRPSYSGVADRGQTQPPLARQSSAHKQALYSSPIDRLRLPRTGLINLGSTCYMNSIIQSLSATVLLTKFFVDNRFHAQVQKNWKGSQGVLPGLFANLIRSLWKNDVEVIRPTSFRKFVGRLNTEWAGSQQQDAKEFFDVLVDCLHEDLNLRWQRTPLRPLTFAEEMRREQMPIHKVSEIEWARYSHRELSYVSSLFAGQHASRLRCTTCRKTSTTYEAFYSISVEIPVTGTGDIYQCLKSYCQEEVLSGDEVWKCPYCKREREAAKQIILTRAPRFLVFHFKRFSASRRQQARKIHTPVSFPLSGLDMTPFMIQHPQHSQSSRPVSPLPDGNDDKLDSKSNSHAPPKSQSALQTNELATSSPYIYNAYAVVRHIGSTMNEGHYISLVRDEQRRCWRKFDDQRVTDFQPSSSRSSPDNLQNEQAYLVFYERAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5M0</accession>
    <name>D4D5M0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000123">
        <property type="protein sequence ID" value="EFE42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023469.1">
        <property type="nucleotide sequence ID" value="XM_003023423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5M0"/>
    <dbReference type="GeneID" id="9583491"/>
    <dbReference type="KEGG" id="tve:TRV_02393"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="243" mass="27755" checksum="D97454CE17867745" modified="2010-05-18" version="1">MAEFVRAQIFGTTFEITTSSAKDQLTNQAVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARVQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDVWSAGCIFAEMLTGRPLFPGKDHVNQFSIITELLGTPPDEVIQTIGSANVGAFSLYFNFSSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Q0</accession>
    <name>D4D5Q0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho guanyl nucleotide exchange factor (Rom2)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023439.1">
        <property type="nucleotide sequence ID" value="XM_003023393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Q0"/>
    <dbReference type="GeneID" id="9583459"/>
    <dbReference type="KEGG" id="tve:TRV_02423"/>
    <dbReference type="HOGENOM" id="CLU_001251_6_0_1"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000035">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="556"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="141926" checksum="441E42EDE5CD6B70" modified="2010-05-18" version="1">MADLGAQQGRGYRPGASRGPASSSFQRDAAFSEIFGGTPPPGRSQTMTSHSPQFNQERAHTMTSHQSDPYAQSRGPPPPMRQSRGGYPPNPQAGYQNSQWQQPNGSGPPPQQRAPPPPHHQQRPMPPQNPQQYPPGMQQRPYPGRPQYPHPQRLDSRPGPMPPQFQQQNPHGRPLPPPALNSDQYRSRSMARLGGPPSYQSPQSQFPPTPVNAFRQPSYHSMGSRTAQGRIVPERHDNERAMSMSSYSADRDHAQTISSGRVVPNRRRESGLERERAGGMDRHYSESPVSIQPTIDEPLVPSHSGHHVLPSQQDLQLRVRHPSESSVNSRTLSMASTIAPERNNSLQKPVAAKSPNSSMAGAPPPNNVHRRTPLAYPALLSRVAAVFRERIAVGERIKNDLAYTNAFTGAEAVDLISYIIKTTDRNLALLLGRALDAQKLFHDVTYDHRLRDAPGELYQFRETLGEESPVNDVNGVFTLLTECYSPTCTRDQLCYSIACPRRLEQQARLNLKPQPGLRPSASKGSLHDHEDNDDQKLWINMVPKEVADSLEDREKKRQEIIFEMMYTERDFVKDLEYLRDFWMRPLRSPNNPSLSPIPEHRREKFIRTVFGNCLEVLSVNSKLSEALNARQKETPVVKTIGDIFLQFVPRFDPFIRYGANQLHGKYEFEKERSSNPAFAKFVEETERLKESRKLELNGYLTKPTTRLARYPLLLEGVAKYTADDSPDKEDIPKAIVLIRDFLSRVNTESGKAENHFNLVQLNSALKFTPGDYVDLKLTEENRVMLIKMAFKKGPTDSAEVTAYLFDHSVLLVRIKPVNKREEYRVYRKPIPLELLVITQMEEVLPKLGIHKRPTAGGLIPGTRTASATPASSKEGLPVTFRHLGKGGYEITLHATSQTQRKRFIELVEEQKRKLRERNSNFYSKTILCEGFFSAVNRINCLVPIDGGRKLVYGTDNGIYVSERWPKDKSATPKRVLEANAVTQIDTLEEYQLLLVLANKTLSSYPLEALDTSDNQSAMVRRPKKIQGHANFFKSGIGLGRHLVCSVKTSTLSTTIKVFEPMENLAKGKKKPLSKMFQTGQDALKPFKEFYIPAESSSVHFLRSTLCVGCSRGFEVVSLETTERQSLLDQADTSLDFVARKENVKPIHIERLNGEFLLNYSDFSFFVNRNGWRARPDWRIAWEGNPTAFALSYPYILAFEPSFIEIRHLETSELVHVMTGRNIRMLHSSTREIIYAYEDENGEDVVTSLDFWNKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5R4</accession>
    <name>D4D5R4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin type II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_02437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000127">
        <property type="protein sequence ID" value="EFE42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023427.1">
        <property type="nucleotide sequence ID" value="XM_003023381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583447"/>
    <dbReference type="KEGG" id="tve:TRV_02437"/>
    <dbReference type="HOGENOM" id="CLU_000192_5_0_1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="169"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="931"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1628" mass="186546" checksum="8308FC067A9E7C12" modified="2010-05-18" version="1">MHPSFNSPSRRHNPFSRSSPSPSPAPPDAAPRVSGRPKSVTFTSPVQTYASGHVRNGSLTPLNPTPINGINRQRSNSARHTSESSNTFAPKFIKSEELRRGADQIRGEEGDNDFSGKRYVWLKDPERAFIRGAVLRETEGGLLVVQCDDGRQVEVDPEGVDKVNPPKFDKADDMAELTHLNEGSVIHNLHTRYQADLIYTYSGLFLVTVNPYCPLPIYSNEYVKMYKGQSREDTRPHIFAMADEAFRNLVEEGENQSILVTGESGAGKTENTKKVIQYLAAVAPGDAQGKPSSKQLGDLSQQILRANPILEAFGNAQTVRNNNSSRFGKFIRIEFSRTGQICGAFIDWYLLEKSRVVKLNSQERSYHIFYQLLHGASKELREQLHLSNLDIQDFAYTKDGNDTIAGVSDEDEWDTLVEAFDTMKFEEEDQLAILRTIAAVLHLGNITVGKESLRADQAKLTQDDTESVMHACHLLGIPLEPFVKGLLHPRVKAGREWVEKVQTPEQVRFAIDSLAKGIYERGFGDLVNRINHQLDRSRISCEETYFIGVLDIAGFEIFGTNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYSREQIEWQFIDFGKDLQPTIDLIELSNPIGIFSCLDEDSVMPKATDKTFTEKLHSLWDRKSPKYRASRLSQGFILTHYAAEVEYNTENWLEKNKDPLNDNVTRLLSKSNDPHIANLFADYAEDVSNGTRSVVKKGLFRTVAQRHKEQLSSLMAQLHSTHPHFVRCILPNNKKRPKLFNGPLVLDQLRCNGVLEGIRIARTGFPNRLTFNEFRQRYEVLCRGMPKGYLDGQMAVTYMVDKLGLDKSLFRIGLTKIFFRAGVLAELEEQRDTLIREIMRQFQSLARGFIQRHIANKRLYRTEATRIIQRNFHLYLNLKSSPWWRLFATMKPLLGETRTAGEVKKRDEKIQQLEAKAQQDIAERQRIEDERRKIETEMQRIRKTLESERSLALDKEEIFKRLQLREVELSEKLAGAIADQESLEDQLDELIAAKKKIEHELDLRRGQLEQAAQIMERLEGEKKELQERISDMEKQLKSVESTHGEYDEKIGALNQEINTLNSHLAMKDKKLQDLEAKLLSSDQQLDLELANTTKELEGSKKQIKQLLEENREIQRQIADLSSTSTGYEELVRRKEGEVAILKADLKKHEFEKRSLETEKRGLSDRHDDMQRRIRDLQAEIDTTKLEKANFEREALDARKLLEEKLSEDAESAQGRKMLDKQVQDLKTQLYQTQAELSRVQQSRDDVQMLSEHKFAQLKEEFDILNEAKITIEKEMYIQQDTLRRAKEARAAAEESRKQLQGEVIKLRDRITKIEESRLNAENTFANKMTAQATERLAKLQAELNEKSKALNDAEAGHARLSSQVQNLSNLIAKSENFRTENDQHKERLERELVTVKGRLAASENDNRALLNKVQQKNLDIARSNSRAGDTQRARLAQLQTEKSRLEESNKQLTRQLGDAQLSITSLEKQKEKLALSAEDLNHEVAREHKASRNAEKTAATAQLQLAEANRNLETERQLRTQAQANTKKLQASMDRMNSELEDCHQQLILLHKVFDPNDTSPTEKSWETIKPDLSKKVDMAALLETAHNDLRISEEKTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6C4</accession>
    <name>D4D6C4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023186.1">
        <property type="nucleotide sequence ID" value="XM_003023140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6C4"/>
    <dbReference type="GeneID" id="9583237"/>
    <dbReference type="KEGG" id="tve:TRV_02649"/>
    <dbReference type="HOGENOM" id="CLU_014183_1_0_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF2">
        <property type="entry name" value="CELLULOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055287" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="306" mass="33874" checksum="7E135BE0908FE38A" modified="2010-05-18" version="1">MERVMAKVLFLFFTLCALVSFLSATPPRWPGRSQYQHSSDRIVSSVGQGSATRQPGALRVMFVGDSMTQGKQGDWTWRYRMWQWFQAEGIPVTFVGPYTGTVEPDAPAPPMNKLEEAPKASSIKTSGRYAPGVSPDFDRHHFAVWGRSAAFDKDLIYDVVSAHPADMMLLMLGFNDLGWLFSKPMDAVASLYGLINNARKANPNLKFAVANIPQRSFIGRGDLPVSTDEYNSILRLALPQWSTEQSPIHLVELQEHYSCGTSNCEAGYDGLHPNAQGEFQIAHAFTLTLINDFKIGSSPLVVPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6F9</accession>
    <name>D4D6F9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023162.1">
        <property type="nucleotide sequence ID" value="XM_003023116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6F9"/>
    <dbReference type="GeneID" id="9583182"/>
    <dbReference type="KEGG" id="tve:TRV_02684"/>
    <dbReference type="HOGENOM" id="CLU_045202_1_0_1"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="374" mass="40100" checksum="BAD2E9E882F87D21" modified="2010-05-18" version="1">MSLIFVEIEETAKPRASFASKSAKHHDIKTIPSASTEERRGLNLKLLTCRQLLLIYIRTLAWNPTGTLIATGSVDRTLRIWNPERPDVRYSTDLRGHTSGIEQIAFNPVKESELASCSKDGTVRFWDVRAKNCVGRVDVGGEAFSLAWSPDGSVLLAGRMDDTLVPISVEPVAMSTNPAPNAPKAPSTYKALSHHKQPIRTNGIAFSHSFDPNLFLTTGDGTVKIESYPSFDTLHTLNAHTAACLCVSLAPTARYLAIGGGDSLISLWDTTNWVCQRTVSSSGGGAVRGISWSWDGRFIVGACDETDCGGTGLEIFHAETGDSVYTIPTGNPNVGVPAVAWHPSRYCLAYSLYAEGIGSGNNGLRIVGAGAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D702</accession>
    <name>D4D702_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022975.1">
        <property type="nucleotide sequence ID" value="XM_003022929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D702"/>
    <dbReference type="GeneID" id="9582994"/>
    <dbReference type="KEGG" id="tve:TRV_02880"/>
    <dbReference type="HOGENOM" id="CLU_041575_4_0_1"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="259" mass="29303" checksum="3DCF4A2EFB02258D" modified="2010-05-18" version="1">MATEANLRSGSISTAQSPIITNLRDDIPKPVWNPAPAIVTLYDFPSMEPIQYLEYKPEHLLLPLRRDILHRAVIYEGDKTRQGTASTKWRDDVRGSGRKIRPQKGTGRARLGDKKSPMLREGGVAHGPHPRDFSTDLPRKIYDKAWRTALSYRYQRGQLIVVNDNISLERGASVHLLHDIFQTHGWGREFGRSSLITEVKKERLFRAVAEIGQEARALDRADVDVKDLLETGRLIIEKKALDKMLALHSSNLGRPLGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D712</accession>
    <name>D4D712_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022985.1">
        <property type="nucleotide sequence ID" value="XM_003022939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D712"/>
    <dbReference type="GeneID" id="9583005"/>
    <dbReference type="KEGG" id="tve:TRV_02891"/>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="4">
        <location>
            <begin position="151"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="450" mass="49067" checksum="4EF0504F277394A0" modified="2010-05-18" version="1">MKPYIDGMLRGATQGPDIQPTPVSVPAREAVAGTNLAHQPPRGQVRNASTLGEVESLLASAKSSCAVIFFTSSTCPPCKLVYPTYDELAEEAGSKAVLIKVDIGRAYDVSSHYQVRATPTFITYLKGKKENQWSGANPAELRGNVQLLLRMAWPPHPHSSLKLPSLERHIDQYISYRKVPPLDKLLSKVGAAASDANIVALVNFIKASNTDQPKPPLPDLSQLTFFVKTKFLSLPAETHFAILDLFRVAFADPRVSGYFAEEHGHGTILTLLSRANDLADTPYSQQLVMTHLACNLFTSHLYLTQLSSHDALRHTCIKLATNALLDHRSSLRATGTSLIFNLAAANHNKRLLDPPEAESLPEADQFELVASVVEAIRAEKESPETLHGLLLSLGLLVHHAPTEGEVVELCMALEVESIISEKTALDAFKKEKALLQEIGQELIGKGLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D767</accession>
    <name>D4D767_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Unfolded protein response Orm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022959.1">
        <property type="nucleotide sequence ID" value="XM_003022913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D767"/>
    <dbReference type="GeneID" id="9582978"/>
    <dbReference type="KEGG" id="tve:TRV_02947"/>
    <dbReference type="HOGENOM" id="CLU_072117_3_1_1"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22094" checksum="5EE72976934D35D3" modified="2010-05-18" version="1">MSQTRAGRRRRSSSIIYQEPPESIEHTSDQAALPNLNANWVNAKGAWTIHFVLIIALKIFYDIIPGVSQETSWTLTNISYMFGSFLMFHWVRGVPFEFNGGAYDNLNMWEQIDNGDQYTPAKKFLLSVPIILFLLSTHYTHYDLTYFIINFLAVLGVVIPKLPIVSCTSFSHSAFLYSRDMVSNPGFNSHIACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D774</accession>
    <name>D4D774_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022906.1">
        <property type="nucleotide sequence ID" value="XM_003022860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D774"/>
    <dbReference type="GeneID" id="9576944"/>
    <dbReference type="KEGG" id="tve:TRV_02954"/>
    <dbReference type="HOGENOM" id="CLU_1020107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="31284" checksum="5AE8FCB672382C27" modified="2010-05-18" version="1">MAYHDVQSIKGEIQFEPSAGRIEVMHFELDSLSFLTFSALFGQRQAGQGIDNQLPSSFADSILEGPSHYVHILDGEIEELSGKLDVYIQKTSSLFIEGEQSDFIRQTLRQALELAKQHEACSSPTASYPFIYLMVDDMLDAALELWVATAILVDPFLKWTVYMNPTLPPLANRPLTSTTNDSRIPIHSMNQLESYSLICTQLRSAVEKRAARVCRVLLSKFEQRLLQKQRVGSFRTFLATIILLNCVERMEWLFRSWECEHYIQRVRLIQHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D775</accession>
    <name>D4D775_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022907.1">
        <property type="nucleotide sequence ID" value="XM_003022861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D775"/>
    <dbReference type="GeneID" id="9576945"/>
    <dbReference type="KEGG" id="tve:TRV_02955"/>
    <dbReference type="HOGENOM" id="CLU_642810_0_0_1"/>
    <dbReference type="OrthoDB" id="5417895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="46951" checksum="CDBDA0EEBDD5DE5D" modified="2010-05-18" version="1">MGRKPNTLITEFFHRGEKLPDSSNRYEHTCKLCGEKFLKGRPDTLINHITKICPAISTADRDRVAYLSGAAANRYRDKGAVRNSQPAPSSNTAAMGDQARGKRAANFQNGPSLNGLNVLAEASRRVGASNEGHIQDRILELSAAERDMVVDPALENSSKFSLGMITATYTMSLHPCANMPILEAELHAQFIHTSSPTAPFFSTSSVDATSPLPMPAVHSLLPVDTHPDHHSSQLSLIAASANEMVTDDPSSSLESAAMCHQKSDAWQLPPQTAPPQATIGLSPTIELPTADEMMIQNHIPAELSMPPASNERPGTYLRPLTTNPEVQQSNSDFFCEVVDTKKSNKKRSTFSEERRKEVRVVRKMGACLRCRMLKKTVSEYLNRYSNVQLRYINVCHDVSAQLEHLVASAGIFRIREFGWSVVSELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D781</accession>
    <name>D4D781_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000151">
        <property type="protein sequence ID" value="EFE42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022913.1">
        <property type="nucleotide sequence ID" value="XM_003022867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D781"/>
    <dbReference type="GeneID" id="9576951"/>
    <dbReference type="KEGG" id="tve:TRV_02961"/>
    <dbReference type="HOGENOM" id="CLU_021544_2_1_1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="545" mass="59762" checksum="8346731444E56294" modified="2010-05-18" version="1">MDFELSDTSSELSSLPSTPPSDDSLYPSPPESQTCQAQPAAASKAAGTVESAPVRKKRKIEPKPRITRHLDLTYPDKQVCPGQEEQLKLLLRTLREHRKIVVVAGAGISVSAGIPDFRSSHGLFSTLKKDHKLKASGKQLFDASVVYQDESMISSFHDMVRTLSKLSASAKPTAFHHLLARLAHEGRLLRLYTQNVDGIEASLPPLQTKVPLEVKGPWPTTIQLHGGLHTMVCQKCSKASSFEADLFKGPDPPLCAECEKNEKIRTVVGQRSRGIGKLRPRMVLYNEYNPDEEAIGSVVSADLRARPDALVVVGTSLKIPGVRRIVKEMCRVVRGRRNGTTVWINHDPLPSGKEFEDCWDLAIKGDCDKVALHAGLKRWDDDDRSFNECTEEEFDRAKSGNTEISVVITPQKPVKFADFTNGMPTPSSSSEDSVNPGKRSQSPTPSAPPKPRGANTKIIKKSNQPRKPRAKKTKPADASTKTIPINKAFPSRKPTAAKESKVVKEVTPRCKIEDVLNPIAPESARSNGPAPLELETKKESNAVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7K3</accession>
    <name>D4D7K3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022789.1">
        <property type="nucleotide sequence ID" value="XM_003022743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7K3"/>
    <dbReference type="GeneID" id="9581524"/>
    <dbReference type="KEGG" id="tve:TRV_03085"/>
    <dbReference type="HOGENOM" id="CLU_090700_0_0_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="246" mass="27582" checksum="DC105DDB44C7ACE9" modified="2010-05-18" version="1">MDFFSRSRRIIYSPQPLTSFHETRSEALINPHGYAIVEDCLIARVKADTLVHSTLFPGKNLPLGQLSDEELLARFTRGFFGGIIFAAERFILASDTQPANPGLSLPKNIWKATEIPKTTLLPLGSILFGAFQVTHSHLVNKTRLNPTSEGLTKWKSAEEKFSYIDFGFGNGNFAGCHRLSVHRNDSSKGINSITKCADDRDDMIEFRLSCFHCNPRGEESRLVTMLSGFHQVYARLLFTDALRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L5</accession>
    <name>D4D7L5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor RfeD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000160">
        <property type="protein sequence ID" value="EFE42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022764.1">
        <property type="nucleotide sequence ID" value="XM_003022718.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L5"/>
    <dbReference type="GeneID" id="9581466"/>
    <dbReference type="KEGG" id="tve:TRV_03098"/>
    <dbReference type="HOGENOM" id="CLU_029950_1_0_1"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="345"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="470" mass="51368" checksum="6D094FDFA171C93F" modified="2010-05-18" version="1" fragment="single">QQQQLQAREKDVEHPAATTAAVALAQLQQHHRLDWDSEPVLSCPSPLLSLSLSHSPSLHLSLSRPSRLFDFEPMDANCRSSTLPPINRNQKIQRSRKGSLTHSHPARKAKHDRNRSKDFKDFRDITRRRSLNERKALSAEPQTAAAWVQGKRWEDLIEAATSATEVDDRDITPVPQSPPPTSSSSFQPHSPSFNSLASIKHRSSVPPAFQSPPTSNQNSTSITSQPAAATSHPLQPTPYTASPLQKSQTPPPFHRDRDTDLEPFPSIESSMDVTKPYLSPPRPVTSYPQQQHNIYPHPHPHAHHPLHPLHPRHRLSNPAPFTSTSASSSTSNVSISRDKDLHIHIYCASCSRPKAIRDCFACTECICGVCRDCVPALSLSMHSSAGSPPSSSSTVGAMGISVLNLGPTSSPRSGGSSAVNRLARSNSTNTTMSNHSSIHANGKHDGRQGHGCPRCGVVGGKWRAFQLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7P4</accession>
    <name>D4D7P4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022746.1">
        <property type="nucleotide sequence ID" value="XM_003022700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7P4"/>
    <dbReference type="GeneID" id="9581436"/>
    <dbReference type="KEGG" id="tve:TRV_03128"/>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="785"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133010" checksum="33DE2ED06A74A7E9" modified="2010-05-18" version="1">MADSIQPSDGNENTAPQLANIIQALDVIHSPASSNEVRKQASEFLEQQKHEKAALQNGYFLAAEKSHSPVVQHLGLSFLEHVLRYKFLELSPDEVNHTRGLVMSLAEGLRCQDPSYIRNKVASLWVELAKRTWGLEWPQMDESLMHLWNATFTHKELVLTVLETLSEDTIHQEDTASSLRGTDLNRALVEICTPYDVFKVAYPKRDHHTEIRSGSEGWLFRVSYFLSDCVRNFHASTEAKTCALKSLSCLRSLVAWVIPMAIDSSQCVIAICNALEVEDDAVLLAAVEALHSLYGRSTYNIEEFQRLVNIIYQNDHLNLLRKLYEWSIVGADNIIESKYSISKKLSELVSYIAGFLEEKSTDFTKSVDLPIFFSFLISILQNPSLVVSIPVLHSWSRLLASSHIGGLNIVNNLIGQLLQICSQRLVRYEALPEDSDDPTMVFLSEDIDTIPERHAFVGNYRRYCSQVIEVIVQKHTLEAIPHILAGVNSALDNVYAGNAPFNVATFQKQSIPALRADIQFTVVEAMLKGYLKWKGSLGSNPQLDQDPCIKQRVLRLCVDISAKALVDRPSYALKILEHILMVQIPDHPEYSAYSESVRELYNMATYEIRRLAIRYADYFANYYEPLEQKAQEIGKRPNDEGRPHMELSAILLIIMQRARSVDPYIRQARLNSFVEPIKQAWTNQELKLVLGSFKGFYDVLGLDKVHPYLQKREAQKIEDWTAVPLDAEGIHIQEDLSKKFQELPLRPTRTLLAVSTEKVKKDEPAYQIALDLWKDTIPLILPTILQLIRFWQAGISSGSRQEFYSKIAGSKTTLEGLSSSVRGKVRAVREACYSVLFSMSRLENYFYGFPELPVPLSQALYKDAFSLSSHQFSVLLNISRCLIDDCPSNARADFLPPMMSALFSQLDKKVTSEWDIIQRRRIGIVDDDLTEEMKDESILRQLTYSAVIMVASFLDPEREGELKATDGGQPETMRSFIISSTEILEPVLLFCTHALQMHDTRCCVIITRVIRSMLTEFVPATDTPTAATIREFISTEVLKACINSVHDPYFVDMQKDLAQLISSIWILYGPTTNTPRSIILSLPGMLEQKVKAAEVALHGSASSRQQKAIILDLLEGVRGVRISEQGRILGTAVNRRKERSSMQARYMSTEMEGEEAKKVDINDGADLTFVADMFNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7W4</accession>
    <name>D4D7W4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022677.1">
        <property type="nucleotide sequence ID" value="XM_003022631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7W4"/>
    <dbReference type="GeneID" id="9581336"/>
    <dbReference type="KEGG" id="tve:TRV_03198"/>
    <dbReference type="HOGENOM" id="CLU_019361_0_0_1"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="613" mass="68704" checksum="8B8F6CDB9BF24C99" modified="2010-05-18" version="1">MTLAKLEDLPEDILVLIFPLLDVPDFLALCTVNKYFHEVFLTNPEFWREVTTKTFRVPVQPLLRANGPRWYWLYKNLRTQTRVYQWGGEGRPSEPLVNKTWPYESSAVAGIRNIVDLQCGSVLNQLPFCHCLHYGVFYDYSTASGYQRLKFDTEYPATSADSYNKSTAIKQFSSGRRHILGLSDEGIIWSWSHRDHSAKLVEFSCARTVLNSRDPHTPGTVTKVVSGWDTNSAFVAGTGIVYWKINDPPLNNDESVLLIVPGKIVPGTGFQRTNSERGRAEDEAGLGEVISYIVLEGYIVFITDLNKVFATEGDGQRTVELAKFAAPERILKDIQGAFRNFAVFTETGEVMIGNSEHIRTAFDFADDPDHVLSPKLPAGLQHSEVISVSFGDYHYTALHANGTVSSYGSEPRGCGSLGLGSALGGIPLRGLMKPGPGSFSRDVYYFEFAKEKRHNVWFEPEKREWLKYLASGAGSQGDGSDWLTSLEENDQGLLEKYSTCIERAGENWDNLPDVKPEDTDGLGAYFTLSVASAGWQTVALVLVDKELAEKVRRKHLVNVEESNGAEETPRYKWELQKYPPLQTNAQEIIEVNKYDFDTWVYGLPPLENSSIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D810</accession>
    <name>D4D810_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022588.1">
        <property type="nucleotide sequence ID" value="XM_003022542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D810"/>
    <dbReference type="GeneID" id="9581253"/>
    <dbReference type="KEGG" id="tve:TRV_03245"/>
    <dbReference type="HOGENOM" id="CLU_326026_0_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="562"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110660" checksum="6BB3A430D0676CC4" modified="2010-05-18" version="1">MLPPFRIKGIVGHPLHRRRRSRNDDGLESDSASILSPDNQYRAEFEVQGDGVVQVTANEYDRTIEQIPEARLQYQDEDDGETVIVGSSLELSQLIGELLPNSYRLPLSKLNAENDPVMHTFEIQQTLPVVDVWRNFRLRTVTNSISGQPSCQLISPSTGYRSNASYCLKTGSPDPPYATNKPSVVQADTLNESAPSGQHECCLGAVANMGSNKQYPMKDTSSGIWNGPNHDTELESFGEGVSTERKFITEEGKKQVYCLFQISIRRGQTNTLKAYAAGKRMREIYKAYWRGSYRPELEEGHTTGTSGDFWSTYKPTHQFSGPSPSIREREPDSPESPIEASPKPLLSEFEAELSRLMAQNSGLESHPKPIDEPAAATAKESTSDSASTAVQGPEIGPSENNNAQPTSRQATEASEAISHIVTVFGKSFQSLLSRVSILTAELADRLPEVEQRVTDLHHQIPDQMQATIHETLQVMGGHIQTLAGAMQQAATSARSSSIATSEAEKVVTAQLNNLRILASDIRDIGGSLIAGVEKSLKPRDNSANKGTTDASSAPETVNPATKDIFIGNLPPDATENSVISVLASQGFVGTVTFPRDSLTGEHAGFCYVHFPSTYAADAALQALRGKLIGDYTINVEPANEHSLPESSNAAESSGTGIQHPTPELPPLTTNTRRPGFPSFVPVSELDNDTSNIVPSEQNFPTSSLCEQAAIPIPEVHGNTQTQPNTALLDKSEANLAERYPPLFASQSTDNLSTRPTPPDTYPGASLLSALNDDGCGLSRYPSMQQLEQQHLFMHGPWPTPDRPAPRPRTTYENNINLASTGEQLAPPVPSRIPGSWPWDQDSQSSIPSRPNANESRSEHDTSHGPSHINPPVLSDLSSPFNPHRASPFLASNVPGLRRSATERVRRPRPSLFGNNPYPQRPLSSHELAEISAACENPSDLPGTFPREAPTAAVIEASSNDSTELCLSQLRALGFGDDRSQDANRLRIFAEAANGDLADAIEMIEEERKAYEQRHVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D880</accession>
    <name>D4D880_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000171">
        <property type="protein sequence ID" value="EFE41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022554.1">
        <property type="nucleotide sequence ID" value="XM_003022508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D880"/>
    <dbReference type="GeneID" id="9581212"/>
    <dbReference type="KEGG" id="tve:TRV_03316"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28965" checksum="D52A1E5A13A8EC57" modified="2010-05-18" version="1">MLRDQANLGGVEYALNAVNQGVTALGIKATNGVVLATEKKSTSPLVDPPSLSKVSLITPDIGMVYSGMGPDYRVLVDKARKTSHTNYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLIAGWDDGIEPETAEAKEGETDAEKKKASGKTGGILKGGPSLYQVDPSGSYFPWKATAIGKSSTSAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGDTIEIGIVGPPAHHLLGYEGVEGARGPRFRKLSKEEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8E8</accession>
    <name>D4D8E8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000176">
        <property type="protein sequence ID" value="EFE41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022488.1">
        <property type="nucleotide sequence ID" value="XM_003022442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8E8"/>
    <dbReference type="GeneID" id="9581065"/>
    <dbReference type="KEGG" id="tve:TRV_03384"/>
    <dbReference type="HOGENOM" id="CLU_046290_2_1_1"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43125" checksum="88C1428E0F10ACF1" modified="2010-05-18" version="1">MTPDPMTGQQSEQDGHDDPGRRGDGRPKALRRPDDRLGERGQEEEREHEHEQEQDQEQRQEQPFLMLSPTLHAPANGLGPRGHAHVRSRSLAAPSSAPVMARAHSSPGLDSRGRYVFPQSGPGKPSAVGVTPHELPLRRPSPLRTSFDSVGSGSQPLPSSHSIAISEPILEQPELQALPVSYTSHPSQSAASYTAYGSSGSRPGSGRSVSPSWSPALHNTLPRVSRRRPSSPLLTHVPGQTSNGYTSNGHMSNGGILGSSATTASTPSSASSPSRPSPLILPAKFNEPYPAYSLSLASSMPSTPTSIRSRSPSISSLETIPDIPDAEAAAIEADQIARLKAAADKADAAVEAGGFPHDLKRRSAVDISSPSPGSRFGSGWADKRKRWSVCGAEGRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q3</accession>
    <name>D4D8Q3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022426.1">
        <property type="nucleotide sequence ID" value="XM_003022380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q3"/>
    <dbReference type="GeneID" id="9580973"/>
    <dbReference type="KEGG" id="tve:TRV_03490"/>
    <dbReference type="HOGENOM" id="CLU_1011841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="29389" checksum="EA772ABCD993BAFD" modified="2010-05-18" version="1">MLSWRKEDAGKQSRKARLEGLKEAGKAAGRGGGGRKSDRSVKSWTDGCTRRGRLSSVVVFVLFCCSPAAAAAGGRFCGRASDVTLGTTISVKKDVEVFFFCPLFDLDFFSSSSPAGQTSHPARLWSTVSFLFSSPVESTAVFFAGDSPDCTAGFITASGGGLLETRDGHAYARERERERGREDRPRGSFPFLQLRSKVREAEKKFLLAYPYTYGTNIRLWNHVEEKAVFLAVTSDVELALGLGYRLRIRESRDREDRIATQQERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8R1</accession>
    <name>D4D8R1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000181">
        <property type="protein sequence ID" value="EFE41754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022372.1">
        <property type="nucleotide sequence ID" value="XM_003022326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8R1"/>
    <dbReference type="GeneID" id="9580924"/>
    <dbReference type="KEGG" id="tve:TRV_03499"/>
    <dbReference type="HOGENOM" id="CLU_2414895_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="92" mass="10524" checksum="D9AE09050DB925AB" modified="2010-05-18" version="1">MILYLFPPGVPRIFKDKKDDFFWQVFESGHGGLASFVILQYLRSTVQAGDMQSMCSVARKVFDFTGRCINSNVAKSGWKMDAHICFFLLILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V2</accession>
    <name>D4D8V2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022329.1">
        <property type="nucleotide sequence ID" value="XM_003022283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V2"/>
    <dbReference type="GeneID" id="9580876"/>
    <dbReference type="KEGG" id="tve:TRV_03540"/>
    <dbReference type="HOGENOM" id="CLU_064521_0_0_1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056085" description="diphosphoinositol-polyphosphate diphosphatase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="58"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="29566" checksum="F263FFE735FDE6F3" modified="2010-05-18" version="1">MARQNQVFLSLLAFIIVVLGDGDPGGWFHVAQQEVYGCGFESGPSRPPTPHGIGMPNNFAEVVKGIYRSSFPLPVHLSSLAQLNLKTIVTLVDEEWSPEYSSFVRDNGITSRIIPILANKQPNVFTPYSTIVEVLTILLDTRNHPVMVHCNKGKHRTGCVMACFRKAQGWTSVAAIAEYIYHSAPKTRTLDRNYIQEFDENTVADLVKKTGAQKWLPTFPPIKYTFDSEDEENPHMNGNGAKKSELATSAPPVSFHGANGLRHTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9W8</accession>
    <name>D4D9W8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021963.1">
        <property type="nucleotide sequence ID" value="XM_003021917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9W8"/>
    <dbReference type="GeneID" id="9578861"/>
    <dbReference type="KEGG" id="tve:TRV_03911"/>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="465" mass="50697" checksum="158CDA9096435824" modified="2010-05-18" version="1">MVKGVFSDQIELQIQSTTKFRKLLSKERNPPIERVIETGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSHEPDVREQAVWALGNIAGDSPQCRDFVLGAGALRPLLTLLGDGRKLTMLRNATWTLSNFCRGKTPQPDWPTIAPALPILAKLIYMLDDEVLIDACWAISYLSDGPNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDIQTQVIINCGALTALLSLLSSNKDGIRKEACWTISNITAGNPAQIQAVIDANIIPPLIHLLSHGDFKTRKEACWAISNATSGGLQKPDQIRYLVSQGCIKPLCDLLSCPDNKIIQVALDGLENILKVGEMDKEAGQGPEANINRYALFIEEAGGMEKIHDSQNNANEEIYMKAYNIIEKYFSDDDEAGADIDELAPQQTQTGFALGTNQQPTGTFNFANGDSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA08</accession>
    <name>D4DA08_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021922.1">
        <property type="nucleotide sequence ID" value="XM_003021876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA08"/>
    <dbReference type="GeneID" id="9578805"/>
    <dbReference type="KEGG" id="tve:TRV_03952"/>
    <dbReference type="HOGENOM" id="CLU_035845_0_1_1"/>
    <dbReference type="OrthoDB" id="5315820at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="31249" checksum="06E542BAC977F1D2" modified="2010-05-18" version="1">MTTPTLINLPPPPSDPVTPSEMGPSTPNSGTTSLSALSTVAIKDGHQGARRPHSHRPHRSSSNASETSTTTLDAERADRISRLAGLERLSARTAAGGNPLHAHNSSGLSQGEYFDTHPHMLKERSTVGSASATESISRGSLGGRTRTTWASGSDDVYGQDETIDEEDVDPDDADARSTDAFSDEGNASLVGFGEGANSTISGPISTPVQRLAAAGLSRQSSSMTGVSNTAVAGSSPTSSRFSHPITHQSQSQQPPQSPTSAPGSRGAAAVDAQMLDGMTYDEDIVDTTARSPLPVKSDEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA37</accession>
    <name>D4DA37_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021892.1">
        <property type="nucleotide sequence ID" value="XM_003021846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA37"/>
    <dbReference type="GeneID" id="9578775"/>
    <dbReference type="KEGG" id="tve:TRV_03981"/>
    <dbReference type="HOGENOM" id="CLU_024645_2_0_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="45455" checksum="85974ACBA8BB1228" modified="2010-05-18" version="1">MPAVGGHRYTPSTAVFLNEVIKLVIALTAALYELSFTAHTSTTATSLFITLSSKVFSGDSWKLAIPAIFYTISNSLQYVAMSNLEAARFQVTYQLKIILGAVFGVAVLRRSLAPGKWAALFLLLAGVVIMHLQLSSDPLDPDNHKHVNIRRSLSDLSDIFIGRVEEEAPKLTKRSATYEGIIEDMMLAHPRLNANIGVLATLGACITSAFAGVSFERVLKDSHTSTSIWIRNVQLAIYSIFPALFIGVVFTDGETIAKAGFFQGYNWVVWAVIVSQAIGGLATSFCMTFADNYLRLAPGGISIFLSTLVSAWFFDFSPSANFIIGTAIVLSAIYIYLPGMQSGIPPIHIHAAEKSGKPSKIEIDETLSSPNDFSIKLPTTPLLNETGMSTSRPSSPNRHHSRVHSSRGSYFPKQGRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB64</accession>
    <name>D4DB64_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021516.1">
        <property type="nucleotide sequence ID" value="XM_003021470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB64"/>
    <dbReference type="GeneID" id="9578477"/>
    <dbReference type="KEGG" id="tve:TRV_04363"/>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1176" mass="126790" checksum="DC1E2BB8DBD757CF" modified="2010-05-18" version="1">MASTVNNNNNVNSLPSNGAASTPLNSSVSPNTMASRAAGRPSSGVKGPDLSRRQSGSPVDGGQRCVSFFFLFFSFFFYLQIFFSGHCFNRSQKAWTQNINPTTQKPSNAYPQQNGAGSGRKSVVSPSPASKESSTPDQHAHDRLIFLLTAAIVRSPPPSNSITYQANRTQGSNVSLTMKDGEKFTGIFSGSTLESNETILILKMARRPPSESDSAQSNGVSQNEPSYVGSGSDHQLLIDVQDITCLDIQSLSTSGVVAKDQNGASSGFRTDTDISGNQPGRERQLQRWEPSGTDATLDWAPESSGTAGWDQFETNARLFGATSSYDENIYTTRIDRSDPSYKRKEAEAARIAREIESADTDNAHMREERGHVHQQDDTDEEAKYSGVRRDVVAPLPTGQPNKYMPPARRPPTGQPTVPGAPVDPAIISAQLARPDSQTKTSTQPKDTPGKAVTQQEKEKEKAPAAASKSTEGLKTVASNGAIEAERKVAAAGASSQPSAASSTPRTGGENAASNVETEVLDHFRRFANDEKMKLQERRRNQASYDRTIKLNELMKFSKNFKLGTPVPKDLVPILAKDPSKQEEIIERAKRQHEEKNAAMPNKPSTGTPATSTGSTNVTAEAKATSRNSGSSRYEGGNGLPGATPDRQGGYGRGGGRQGYTPMGPHGGRQLQHPGGHSGRGGPGLLSHRLVEIQQQRKGANMGNSPAPLPTQDARMQQHQQQQQQPPPPPPPTGSAAEQGPSNGPPKAATHTPTSSSASTKFNVRAMEFKPNPAASTFTPASAAGGSSAATPVNTRPQSVPRATSPAAFFGSKKPRPTSERPLIVNGFNPVKRMKKEATDAGSKDYAFNGGIPPAYRTAPTWDVSAINEKKTYADMFKPPVVAASASPQSRALNAQMPHQQQLPYHLQHATHTMPPQAAPPTHLIPPQQPPMHYDDHHRMQMSASSSQVFPSPRLQHSTPMAYQHSVGPHNQMAMHGVPPYYPQPGHVRHYPTGLQFSNPPTAAPMMAQTSNGPYMNMPPQSMTPYNPPMQMFSPNPGHAYPQHVPPMQTHSGYPSPSRGAPMMMHQGSQQGPPPQPMMPMNGQQGQGYYPPQQPGHMPPMRPGHHQQHPHFASSPHQAHNYPHHQYRSQTQNNNNSNNNNFNQIPHGPPPPMQPQGGQPPGPTPSVHPTEAPEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBM8</accession>
    <name>D4DBM8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021373.1">
        <property type="nucleotide sequence ID" value="XM_003021327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBM8"/>
    <dbReference type="GeneID" id="9578253"/>
    <dbReference type="KEGG" id="tve:TRV_04528"/>
    <dbReference type="HOGENOM" id="CLU_001645_9_12_1"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="185"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39673" checksum="8D94E6EA57DE9B14" modified="2010-05-18" version="1">MERHRRAAGALSQDPAHKWTLDTSPQVKARNRYGDVQAWENCRVHLKVPAGECDFINASPIVLKDPETDGEYKYIASQGPKRDRLADFWNMIYHEAGEVAVLVMLTQTVESGKEKCAQYFPQDMENPTFEFSSHSTTEPPAAHFSGSVTLLNTIYDESIRSNVSELELRVGSNTKTVWHFLFAGAGVGRTGTFIALDHLLRQLQSGQLLKADDKSADAVFNTVNRLREQRMLMVYNAFQYQFIYDVLKEQTQIKLGIQSAPIEPRPQKIAKPDDGMFKPELVALSPADIGSAAEPDDPESENNEAKDVGRDKESKGDKENNDNHEADDDDDDEDEDDEDDENDNDKAEDEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBV8</accession>
    <name>D4DBV8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021296.1">
        <property type="nucleotide sequence ID" value="XM_003021250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBV8"/>
    <dbReference type="GeneID" id="9578141"/>
    <dbReference type="KEGG" id="tve:TRV_04609"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="426" mass="46186" checksum="BBCDDB158179968C" modified="2010-05-18" version="1">MSVILCTGMSPSRILITSINAANWLSMLGLAGYDHIIRFWEALSGICSRTIQHPESQVNRLCITPDKRFVAAAGRHRVYLYDIRSTNPNPVMKFDGHTNNITGVAFHCEGKWMVTSSEDCTVKVWDVRSGTLQRNYTHKAPVNDVVIHPNQGELISGDGSGFIRVWDLGESRCTHQLIPEEDVSVASVSVASDGSLLCAGNNKNQDETSIVPVATFQAHKDYLTRVLLSPDVKHLATCSADHTAKVWSLDPEYGPAKMAAAAREKAAKEAAQKTPGPASAATSVTASPNGQKGEAIKTPPKTRTEWNGKGSPASGSIIASGGSTEISASELTQNDSFVSDQPFSSFLDGPPMDHTTNTLFLETTLASHQRWVWDCAFSADSAYLVTVSSDHCARLWELSSGQIIRQYQGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCP1</accession>
    <name>D4DCP1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021031.1">
        <property type="nucleotide sequence ID" value="XM_003020985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCP1"/>
    <dbReference type="GeneID" id="9576678"/>
    <dbReference type="KEGG" id="tve:TRV_04896"/>
    <dbReference type="HOGENOM" id="CLU_029790_1_0_1"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="35282" checksum="45B436DA46669D95" modified="2010-05-18" version="1">MQNSRTLARIIWIHKTEREGEEGKEDIISKLTGINLIVAFAVALKHKLRFEPGSGYEDISGLIDHLDTFAKAANDPNAASGKKPGMMKALGQYLSIPMAMSNPRKQIKRSDKPLGNLPAEILNYLSAYIHESLINGSIPMPVHQSQAGACLNALEEVMTGNERVLNTPLPLAYTILISQITWLYVLALPFQLVNKLEWVAIPGTIAATYIIHGIASICAEIENPFGDDVNDLPLDVFCQQLAADLDIITSTPPAKADDFINREHNYVLYPLSKSSVNMWKDRSVEDIRAALKAKATLTPARLNEAGSRDIALAVKGQDESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDH7</accession>
    <name>D4DDH7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane fusion mating protein FIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020737.1">
        <property type="nucleotide sequence ID" value="XM_003020691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDH7"/>
    <dbReference type="GeneID" id="9577436"/>
    <dbReference type="KEGG" id="tve:TRV_05188"/>
    <dbReference type="HOGENOM" id="CLU_068733_0_0_1"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055497" description="Membrane fusion mating protein FIG1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27182" checksum="13C43725F86A18D5" modified="2010-05-18" version="1">MVGYHHVLMLFVAISILLLSLLLAGCSSSSPQIPSIFLISMFYDKYPPVMSTAQADPGLSSTISNIVGGAHLEVRVGYFGICIQRNGGGFLCNQNATILAESFGVESDPLNLIWVASTFKDAVVFPYLIIVALIFAFLSFLLLATFPGWHEELNNQGSDIEVKPFPSRPVSQVALALIFVASVFILVSVLWQHTASVAASTIAQDLGNGSVKSGVGTSAMLLGWFGFAFFIIVSIGLLCMILSINYFSQLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDV7</accession>
    <name>D4DDV7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000274">
        <property type="protein sequence ID" value="EFE39967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020585.1">
        <property type="nucleotide sequence ID" value="XM_003020539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDV7"/>
    <dbReference type="GeneID" id="9577283"/>
    <dbReference type="KEGG" id="tve:TRV_05321"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="248"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="351" mass="39520" checksum="FB5EBB1507F44692" modified="2010-05-18" version="1" fragment="single">GLEYRDQTDDQVTVDAAEAIKKYGVGVKCATITPDEARVEEFKLKKSKSTTPRYIFCPVLLTPYLSVAISQWNHQKHPYRATDRLIPGPGTLELVYTPAGGEPERIQVYDFKGPGIAQTQYNLDESIRGFAHASFKLASLKSLPMYMSTKNTILKKYDGRFKDIFQEIYDKEYKADFEAKGIWYEHRLIDDMVAQMIKSEGGYVIAMKNYDGDVQSDIVAQGFGSLGLMTSTLTTPAGDAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLVRRGQLDETPEVVNFAEQLERACVEVVDIEGIMTKDLALACGKKDRESWVTTKEYLAAVERRLQKNLGEETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE29</accession>
    <name>D4DE29_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020499.1">
        <property type="nucleotide sequence ID" value="XM_003020453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE29"/>
    <dbReference type="GeneID" id="9584247"/>
    <dbReference type="KEGG" id="tve:TRV_05393"/>
    <dbReference type="HOGENOM" id="CLU_041441_2_0_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="306" mass="34177" checksum="502A7AEACFD36A7E" modified="2010-05-18" version="1">MKTRILILSDTHAMSYTPPSQYADVALHCGDLTERSTLEEYRSAAQLLKQVNAPLKLAIAGNHDFTLDIPFYKAKLEQIHVERHTQLMKECGDFGEARQLLEDAGIILLDEGIHRFNLANGACLSIYASPYTPVYGHWGFQYYRQQGHQFEMEGVDIAMTHGPPKGLLDTAFSGHQAGCTSLLGAVSRARPKIHCFGHIHEAWGAKLVTWRNTNSLFSLFSNSNPVDEEKSILINSLMGARDSKALLDKLQSHRDEGYYTLSYCSDDETPIQSGQQTLVINASMKGLGWNTCHIPWLVDIELPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DED2</accession>
    <name>D4DED2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020381.1">
        <property type="nucleotide sequence ID" value="XM_003020335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DED2"/>
    <dbReference type="GeneID" id="9584140"/>
    <dbReference type="KEGG" id="tve:TRV_05499"/>
    <dbReference type="HOGENOM" id="CLU_067902_0_0_1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="270" mass="30145" checksum="E76E5AF15C79B996" modified="2010-05-18" version="1">MKFFENTFNYDYSFPAVTLAYFLRYPNPYSRHVLASDVIDRYVDPVTKRLHTTRLHLKKSKVPSAMLKLLPKGIGGADNSGQSVILETSVIDVNEGWMRTESRNMEWTGVLSVVERQEYHRCRAENADSSASSSLSALSGGLGIDDNLKGECTSVKTTVTFKSRLGQNMLGRSKKDTTVDDEAPKKGFFASWSTAGIQRTIELIGVKRTRDAVLRSKQGMNVVLERLRNGGIVGVVEGMRQDREGIPAHGGPWKQVWLNGTQKEGHYDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH9</accession>
    <name>D4DEH9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000295">
        <property type="protein sequence ID" value="EFE39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020353.1">
        <property type="nucleotide sequence ID" value="XM_003020307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH9"/>
    <dbReference type="GeneID" id="9584092"/>
    <dbReference type="KEGG" id="tve:TRV_05546"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="399" mass="44534" checksum="DCEF9792A2DD81BC" modified="2010-05-18" version="1">MNVYFNEQHTNSLEAKASSKKYVPRAVLVDLEPAALDAVRAGPFGQLFRPDNVVFGQSGAGNNWAKGHYTEGANLVDQVIDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPMVSDTVVEPYNATLSIHQLVEHSDETFCIDNEALYNICMRTLKLTNPSYGDLNHLVSAVMSGVSTSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRNAYSFRAVSVPELTQQMFDPKNMMAATDFRSGRYLTCSAIFRGKVSMKEVEDQMRNIQNKNSAYFVEWIPNNVQTALCSIPPRGLQMSSTFVGNSTSIQELFKRVGDQFTAMFRKKAFLFWYTGEGMDEMEFTEAENNMNDLVSEYQQYQDASVSDGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEM8</accession>
    <name>D4DEM8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020321.1">
        <property type="nucleotide sequence ID" value="XM_003020275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEM8"/>
    <dbReference type="GeneID" id="9584060"/>
    <dbReference type="KEGG" id="tve:TRV_05597"/>
    <dbReference type="HOGENOM" id="CLU_024934_9_3_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="425" mass="47250" checksum="37A53970DA3E9C3A" modified="2010-05-18" version="1">MTSDSSSSTSSTPPNDARQWQTVFRVRLNPQPAHSQARQLVVEKRRASGFHPRRSHRKSRAGCLVCKRRKVKCDEARPGCRNCSNYGVACSYPVNLDAGNRTRTIGPLGDPSMVMFSMSLDNLTTKIGETLSVYLGSGIRMPGMSGSDRPLEVQALRHFVGCTVETISTVSIRELMRTKVVQVAFAAAEADHWLKAIKSYREALSHEVSAANIDALLTSCMLMAVNCMCPENFTPKDSWVLTSDPSAMNWIYLQNGLPYLLEIGGPFIPQSIWGPAFVAAEEAHDELLNHCPQGREGMNPKLADFCGITYSTTAETSPYFKPLQVVSTMLEMEKSPSTAGYFSSFLGHLDPRFLELLRVRDTRALIVMAHWMGIMCLISHWEPWVEGRIRSECIAICIYLTPSADTRLLELLRFPSIASGFIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEN1</accession>
    <name>D4DEN1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000302">
        <property type="protein sequence ID" value="EFE39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020307.1">
        <property type="nucleotide sequence ID" value="XM_003020261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEN1"/>
    <dbReference type="GeneID" id="9584049"/>
    <dbReference type="KEGG" id="tve:TRV_05600"/>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="283" mass="32505" checksum="785089A194C79FB6" modified="2010-05-18" version="1">MLMRVILLGFKKNVNRATTQVMMKTGHVEKTNDRDYEIEERRYRTMESAANRLQKEAKGYLDSLRGKYPSCNLPENQLLTRLTAMTASQMRIAETIDAFYGDAGAKDGVSRSYKQAVEDLDAETIKALDGPYRTTVLDPISRFCAYFPDINECIKKRNHKLLDYDSMRAKVKKLVEKPDKDASKLPRAEKDAEMAKQAYDQLNEQLYNELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDSDTREEYASGNLDNKVEQVLQEIRDLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DER5</accession>
    <name>D4DER5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000307">
        <property type="protein sequence ID" value="EFE39658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020276.1">
        <property type="nucleotide sequence ID" value="XM_003020230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DER5"/>
    <dbReference type="GeneID" id="9584014"/>
    <dbReference type="KEGG" id="tve:TRV_05655"/>
    <dbReference type="HOGENOM" id="CLU_1050496_0_0_1"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="265" mass="30106" checksum="D39197077E1D91EB" modified="2010-05-18" version="1">MLLLDYHNVLIHSLLTERFSGAAPVSIDQIVSDFDGVTFHVSTPETKSKILISIAVRCFRELVQYGAEGVLQREYGPYIVSPEPGYDFSILIDLEDLPAEQEARDQLIMSIALMKRNAMASPFERGFEEFQKLEEESNKYSLEALPQQLKDGGEVMTVHYRDEEAIFIKAGYDCVTVIFSTIFRDETDKIFGKVFLQVCHNGLYPLLSISLDLSSDFLIGIRRRSKASHTKRPPSPIPQRSTARTPRDSRPKGLSKWGSRLHHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFB3</accession>
    <name>D4DFB3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020086.1">
        <property type="nucleotide sequence ID" value="XM_003020040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFB3"/>
    <dbReference type="GeneID" id="9583850"/>
    <dbReference type="KEGG" id="tve:TRV_05859"/>
    <dbReference type="HOGENOM" id="CLU_002265_2_1_1"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="594"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="860" mass="97109" checksum="7CA24E0E5A7670D8" modified="2010-05-18" version="1">MTLIPTRPSLNSGAIGLLDPKLITGMIILHAEKQYNKDGMLKAFSDTPEPFTTGFAPLSNMLRNLFLQKTSLWPRFQVTVAESLEGHRKAEVIELEVPMTDKMKEIQNAVLECVEVNIRELKRSNTGLDVGDDWTVDSALHKNFDVAIRRQLDPVWHRVSFRTRQIASDLTVLRSILHSLLTFDAVSLNKYLDTVISAHSAPAGSTKQNYSPWLFLGAAHVLFDTAKSRVYKKKASEKTTSSSSDIFNGIEPILEEQPKWAVLAEVLQEIEQDTYLNPAAPGSSNNAILIMCSDQQTCRQVREYLSTMHKKEKFFDKNEDDEAEIIPHEDEHHPSADTMMRRKLREYLYWKRNLSNVNNHLYDVKPKTKGIAEVPGFTSISSVAPQGHSGRAPPNKRRRVRGGSSTASSSGAGRPAHGSVQVDTEDFPEVSNLSEEVIQQAILEEVQHITLEDDLQDMDNYYELYDVNDLLVVHHYDGDMDEHVLEELRPRYIIMYEPDAAFIRRVEVYRSSHQERNVRVYFMYYGESVEEQRYLSAVRREKDAFTKLIHERGTMAMQLVHDKSHEDPQEQFLRTVNTRIAGGGRLAGTAAPPTVVVDVREFRSALPSLLHGRSMVVVPCQLTVGDYIITPDICVERKSVRDLISSLKNGRLYTQAETMLQHYSQPMLLIEFDQNKAFTFDAFTSSATPTSYVADNATSFGSGNMINPANPKSAQHLLVLLTLAFPRLKIIWSSSPYQTAEIFAELKKNNPEPDPIKAVQVGLNFNISGLDTSDGQPADMMPASGIEHRVFSLLPQDMIRAVPGVEPKVLERLILETKNIHEVANMKIEQLEPLVGKEAARKIFKFFTRSVFDSETVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFE4</accession>
    <name>D4DFE4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020117.1">
        <property type="nucleotide sequence ID" value="XM_003020071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFE4"/>
    <dbReference type="GeneID" id="9583881"/>
    <dbReference type="KEGG" id="tve:TRV_05891"/>
    <dbReference type="HOGENOM" id="CLU_299793_0_0_1"/>
    <dbReference type="OrthoDB" id="5394108at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109641" checksum="E7D2D6F6134AA6E9" modified="2010-05-18" version="1">MARTRSQPLSPSGYRMWQTPPRTRKQTAEAAPAAKAAAPKAPKSATTRVTKSKAKKGKKPAPKKRVPGSYDDSDDEHEEAPSPAESSTAHGSHGEKANNNNNKRRSNKNEEVVTEVESPTPAIAPNTTTTRATRSQGPSPSTHQIQVLVPTISPANGRASNHATPSTPTPVPQTAARSGEAVHVPPVPESTTNVEKNDNISTNISGKQAPFQSEPQNISSRPIKPFTRRLPARHQPFSRFAPVASFISPSNLELSPTPIIDLEGGVTRNGERTTPKEIVFYPPPLPTNPAFLTAPQISVERRPLCPCCNRMLVCPASHDTWTHNGFYFTERTKQLTPLPAVTGKRRREVDEDKENEDADNQPVRKAKRAPPKKPRRKPIKSREIHRLRQVTPYADRQRRRALESQGKIQRTLFRIPELIAQKKAAEAASNENNNANDDEHSDIDTISIPAIPSATQLAVVSDFHSSPPQLQPSTPARTVWSFSGLLDSVPRSISRFLPFRADASQNERHEEHSPSQRPGLTVHHENLSQNLSNETEEPGYASRIHENNNNRHDYTTVSASTHAVGPSISEEWKDTPTALPTPAVSAPVRSVALTQPDFDEEDLSYDLFPRNHPLSSYSREAALRKAEEEAQQAREEARLAQEVARQAQEEARLAKEQARQAQETVKIYQPTSSKANANRVSKTTTRKEKKRKPIPNPPGCSYGMDLRYFGSTSSSEAESSDNERPEEPSASVRPGVLKDTTGADSQTPARGPLRQRKQVRFGPSPPEVPSKSRSTDLSTSTVVDDTPESPSQKSTAQATPASLPVSTNASPQDVEMTSPSPLRERESDNQPRGQSTYGFTYEELYGDDFFDDIDEDPVPSGTGASSSSDIVQEVGVLPQPIPRGVLLGHSNGQVAAAPPARSALATMPVPSFRPASVGAAAVERQLADMERFRPRLPSSLRTAERYSSSPVPASSPALQGVVGQGPLSHSFQWPPAADTGFTFEAQPSHERLRVGFRQILTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFG9</accession>
    <name>D4DFG9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000338">
        <property type="protein sequence ID" value="EFE39399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020023.1">
        <property type="nucleotide sequence ID" value="XM_003019977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580192"/>
    <dbReference type="KEGG" id="tve:TRV_05919"/>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2650"/>
            <end position="3190"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3440"/>
            <end position="3786"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3777"/>
            <end position="3809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2011"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3202"/>
            <end position="3266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2027"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3225"/>
            <end position="3244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3809" mass="434565" checksum="1382B60A7E2EEF3F" modified="2010-05-18" version="1">MERESIERNFDAYVTKLGDPNIETKLKCAAAVEIRDSLEHLCSGATYPIFLAKLWPAFKKVLKGEPVFISLSFEQKLRNCILEILHRLPLELPEVEPYAGDMVDLLIELVRNENEDNAVICMKTIMDLQRRQIRATQSRVQAFLELIQNMFEGMPQVVRDTFDTPQAQTSTPGMPSTPNTAAQNFQSPRPSSPATSVSDLGPEQQQTNQMLAKGMHSFKVLAECPIIVVSIFQIHRHPVTTNVKVFVPLIKGILLLQARPQEKAHNEARAQGKIFTGVSKDIKNRAAFGEFITLQVKTMSFLAYLLRVYASHLQDFLPSLPGVVVRLLQDCPREKSSARKELLVAIRHIINFNYRKIFLEKLDDLLDERTLIGDGLTVYEALRPLAYSMLADLIHHVRESLTRDQIRRTLEVYTRNLHDDLPGTSFQAMSAKLLLNMAEKIASMENKKEARYFLIMILDAIGDKFATMNYQYNNAVKASKLVKQNADNLSEGYLADKNHPPDWDEIDIFTAAPIKATNPRDRNADPVNDNKFLFKTLITGLKGLFYQLKSCNPEDLKLDPSYTPVNWAEVSFGYNAEEVRIIKKLFHEGAGLFRYYGADSKEPEIQYASPLEFLSSQYMRHMSSEEKELLESFGTIFHCVDTAAFHEVFKSEIPYLHSLMLEHSALLHLPQFFLASEATSPAVAGMTLQYLMEHIHEVGSADVANSRILLRMFKLSFMAVTLFSAQNEQVLHPHVTKIVAKCIEYSVTAEERMNYFLLLRSLFRSIGGGRFELLYKELLPLLEMLLETFNNLLLGARKTQERDLYVELTLTVPARLSHLLPYLSYLMRPLVVALRAGSDLVSQGLRTLELCVDNLTADYLDPIMAPIMDELMTALWDHLRPNPYSHFHAHTTMRILGKLGGRNRKFLNHPPELSFQQYSDDTPSMDIKLIGSNKDRAFPLDIGIDLALGKLLDSPAANASETVQKADLFYKKQAYRMLSSQLKLYIGFEHPPDDLATLLRLQANDLADGKFSGTVDILEKSDRQCSSSKRLAQETTLKKLLKACIVASTIPHLKQSATAFLADVCRHFTIIEIGRSLAQSRHIRRPFSVSLGEGPLYLDTRTLADAVVECLASENPAVRDAAKEVIFNVRSAAVVIFGSAEKAGKLPFFPHLGRTLCHACHDEEWFTKAAGSLGIHLFVTELDLGNAWLIDRQVEFIRALMYVIKDTPSDFPGATRTQAQKTMDLILRKCNEGVSKEELKNERGRVLALCGVLSYELSHMNKHVRQAAQSGIATLATTLGAEVHELITPVKDRLLMPIFNKPLRALPFPTQIGCIEAIAYCLGLRQNIVTFNDQLNRLLMESLALADVDDDALASKPNEFKTAEQIVNLRVSCLRLLSMAMGFPDFASGPQSHSRARIIACFFKSLYSRSPEIIEAANSGLRDVLTQTNKLPKDLLQNGLRPILMNLQDPKRLSVAGLDGLARLLTLLTNYFKVEIGSRLLDHMRVIADENILQRASFGLVEQNSPMKIVAAIFNIFHLLPAAATSFMENLVNKVLYLEDRLRRTSSSPFRKPLLKYLNRYPRESWIFMQAKFQEEKHGRFFGHLLASPESSALRSTIFADSETLIKLAFLQEESPRKNTAAINGIYFVHSICSHEATKGFLNAQPDLKRHLLNSGRDLNSKLRNDRLPPDERLRVEQAQDQLLEIFTIHLSQSLDDLDFLFDVIDKISAGELKTTLTLPKFFYQYIITNSSIAYRRSVISRCLDLYNQRTSSQKLKTYAFHHLVNPILAMDVKNTWDSPTPGTGVLDRSLTDLIHNRLWKPQLGDLSEESGQPGIDHSRMELLQLSALLIKYHHGIVQESRKDIIKFAWSYIRLEDTINKYGAYVLISYFIAHYETPSKIVVQIYVALLRAHQNEGKSLVTQALEILAPSLPKRILSGPDPRFPVWARCPRRILTEETANLQQVMSILQFLVRQPDLFYESREYFIPLIIPSLVKIAGPTNVSFDSRKLVLHLINLIWIWEEKRVTGWRDPTSPNSAKRKLAEMQASPSMSTTPLPQKERPEYTIPLDLRTPLIKYLVTFVCSLVDRFSVPAARFRDLLPPKPHQALNNYGEICKKSVVLLRRFLSPEYWPDVDIDLYQKTLEPVLCSEKAEKPDEKHITAMVNSLQVLRILLAGKPNSWILDRMSTIQHLVEKALRSDNPEIQDCLHGGEEEMDISPKLPPPIKRVLDALPQEEPVEEEGGMDVDKPSAEFVTFLSTVATESISSGNYIAGINILWTLSKCQPAEMDQHIPHVMKIFSQKLAKDHVASFNNNPPVANRTAEQQAQVPDPYEVEIGIDLISKTIDLIAVRMSNLGDQRRPFLSVLAQLVERSQNIPLCTKILGMVENWIFQPTESWPTLKEKTAVLHKMLLFESRTDSTMLGKFLELVIRVYEDPKITRTELTVRLEHAFLIGTRAQDVDMRTRFMSIFDKSLTRSANTRLSYVLTSQNWDTLAESFWLTQASQLVMGSVDMSASVKLHPDDFTIPPTSFIYGHSEKDPAKENVVVDNHLEVLVAEQKKFSAELGDVKARDILEPLTELQHADPEVAYKVWVSLFTICWASLTRDERIDLEKGMVSLLTREYHHRQIDERPNVVQALLEGVIRASPRFKIPPHVMKFLSRTFDAWYMAAIALERYAIDPVIDTPVVRESNLDALVEIYAGLQEDDMFYGTWRRRCKFVETNAALSYEQQGMWDKSQQLYESAQVKARTGSIPFAQAEYFLWEDHWMICAQKLQQWDILTDFAKHENFNDLLLEATWRNLENWQGDTNREQIDSLLKSVSDAPTPRRTFFQAFMSLLKFHTKQETLQEFNNVCDESIQLSIRKWHQLPKRITNAHIPILQNFQQLVELHDASVICTSLSQTNERNMDTKSAELKLLLTTWRDRLPNVWDDINAWQDLVTWRQHIFQLINSTYLSLLPPQTNNVASNSYAFRGYHETAWIINRFAHVARKHQMPEVCINQLSRIYTLPNIEIQEAFLKLREQAKCHYQNPKELNSGLEVINNTNLNYFNAQQKAEFYTLKGMFLAKLDHNMEANEAFGVALFYDLRLAKAWAEWGQYSDQRFKADHSDIDQACNAISCYLEAAGLYKNHKSRKLLSRILWLLSQDNDEGKIASAFENFKGDTPVWYWITFIPQLLASLAHREARLCKAVLGKIAKLYPQSLFFLLRTSREDYLGLKKSQEQKQEKFNRAKASGSPTTKSGSPEAKSSMLPDAAAASSSPRAVASPKPTPPVANGQTPNEGDAAQKDKQPWEYADETMAGLKTAFPLLALTMETMVDQIHKNFKCPPDEDAYRLIVALLNDGLAYVGRMPTSYAQDCKLPHSTEANITRFAETILPAHIRKSFEADFVTKKPTMYEYIHKLRRWRDKFEEKLDRRPQYAHLESFSSHLSEFKFMKFDEVEVPGQYLEHNDKNQNFVRIDRFLPHVDLVRGIGVCHRRLRIRGHDGSLHTFAVQHPAARHCRREERMLQLFRIFNCVLRKRKESRRRNIYFHLPLMVPFAPHIRLVKDDPSYISLQGIYEDHCRQTGMAKDEPVLFTMEKMRALAEAKANVSVQNVDNPNPTSANSFQRAPEQAGILRTEIFDAIQKKWVPNTILLQYVQQTYPNFADFWLFRRQFSYQYAAIAFMTYVMHMGNRYPSKIHISRRTGDIWSSELIPAMNSARAIFYNPEQVPFRLTPNIQTLMGPLTTEGIFACAIMAIARCLTEPRLELEQQLSIFVRDELVMWASAQQRVLQQLKDMVQSNIDYIVNRAASLTSSPDGNLPANQSVIDLISRSVNPHNLAQCDALWMAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFU7</accession>
    <name>D4DFU7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, classes I and II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000343">
        <property type="protein sequence ID" value="EFE39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019901.1">
        <property type="nucleotide sequence ID" value="XM_003019855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFU7"/>
    <dbReference type="GeneID" id="9584651"/>
    <dbReference type="KEGG" id="tve:TRV_06049"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="85"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="459" mass="50864" checksum="948D40469B41E11E" modified="2010-05-18" version="1">MSSGDSSATVRLATVSNRAAKVSKETAANKMWDVFTDLYDAATNENGFVNVGVAENFLMHGTLLDYIRTHADLPPHYLTYNDGGDGSRRLKTAASRFLNRHLKPVVPLKPEHLMVTNGVSAAIEHLAWAFTDPGEGILLGRPHYGALLPDMTSRPEAEVVPVSFDDLDPFEVRCVTKYERALLDFEARTGKRVRALMLCHPHNPLGRCYPRETIIELMKFCQRYQIHLISDEIYALSVWENTVDTAPGTPPPVKFVSALSIPTQGLIDANLLHALWGMSKDFGANGLRVGVIISQSNPELLAAIKGPTLYSYVSGLSDHIASSILENEGFTDRYITVNQRKLSESYAFVARAMQDHDIEYAAGCNASFFVWVNLGKAYLRNKQIPIPADLTRTVMDELISKRVFLADGTAFGSEKPGWFRIVFSHPRPFLDKALGRIMAAIGEPYKYASKPECSARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV3</accession>
    <name>D4DFV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019858.1">
        <property type="nucleotide sequence ID" value="XM_003019812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV3"/>
    <dbReference type="GeneID" id="9584609"/>
    <dbReference type="KEGG" id="tve:TRV_06056"/>
    <dbReference type="HOGENOM" id="CLU_000022_0_5_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="976" mass="106251" checksum="52B6BB7FB4B060B3" modified="2010-05-18" version="1">MSLFPQLLLEQVAAVLEVGTEDLELGSGFIKNGGNSLNAVELVTRCRQHGVSLSVAQVLSCNNLNDLFEQFKPCSKPDYRQVRTPCFSDDSEDDSPASLSSIESSPRATTPVPAVEMLAEKEKDNTINTALTMQEPTLDEHATEGLSEMQASLLHGSLKNPGTNIIYHYETFLASMIPQMKEAWKSVIEAEPIFQIPAMGGESDIPGQGQFSWMEVTVDSELEYQKHLQTMGLPSSFSSSFKVVHFPGRDSASSKSTIIWAVHHALIDGYSAMLLFCKVRRIVAGLSARPSPGPSFKQVDRQTGLWRQQHKEEGDAYWRRQAPQLEQSQGDLLLPAPPSKGDTSCSVIESEEIHVISNIPGTQLQGLVRNLGITPAAFYYAAWAVVLSCYTDSDSVVFGAVLAGRNLPLEGVDEVIGPLVNTLPLCVKVDRDLSVEQFLKAVFTQIMELAEYQWTTPDNGYTRNFATAMALQVPEPECPGGILPIEAPYTRQTTDVPLSINVQPNGGARFVYHTSKYSRRDIGGVGRHYQRAMQLLLIPHRSIKECLQGLLGCADLETLMNFGNCHSTLTTTMAVQDDLVTLFESAASKDPDAIAIQKGSLEMTYGQFDAQSSRVASILREYLSPGDVVCAHADRSSNWIVGMMGILKAGGVYCAVDGGLPQEARDIIFSASGANIFLIPSETNKGVCPAACKTLLVTDELVTRDEVPLPHRRSPHPEANAYLCFTSGSTGKPKGVMCSHEGLVAFQRDLEVRLFAQPGHRVAQIMSVAFDGSIHEIFSTICYGATLVLQSGGDPFAHLSDVDSAILTPSMARVLNPAHYDRLSSFSNEGIYLGLSRGGAGSTGLPPGVIGEIYIAGVQVARHYIGMPKETEERFIADPIRRIGERMYKTGDRGYWSSNGDVVCLGRNDRQIKLRGFRLDLDDLETRMVRASSEVTAVAVARQGNHLVAAILPSTADVSAFAARISQVLPPYANPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG30</accession>
    <name>D4DG30_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 213 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019844.1">
        <property type="nucleotide sequence ID" value="XM_003019798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG30"/>
    <dbReference type="GeneID" id="9584595"/>
    <dbReference type="KEGG" id="tve:TRV_06132"/>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22499" checksum="9E2FA30E55A95449" modified="2010-05-18" version="1">MAGQQEAPVYHPQDALKRAINTTMVTGGVGLFTSAVQNTLQKQNVGPWGVFTRSGSTIFLFAAMGGSYEFVKTASANLRTKKDYWNSVYGGFAAGSLVGFRARTFPAMIGYGVALATLLGVFEYSGGSIAGKIADPNVDEYDRRTALRKNFRSPGEETIAELGERRGMSGPHLVAILQLYLSISLQLMIANRPQESRHPDLQRDGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG60</accession>
    <name>D4DG60_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019785.1">
        <property type="nucleotide sequence ID" value="XM_003019739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG60"/>
    <dbReference type="GeneID" id="9583708"/>
    <dbReference type="KEGG" id="tve:TRV_06162"/>
    <dbReference type="HOGENOM" id="CLU_1455403_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="186" mass="20744" checksum="92CCC186AE7340EB" modified="2010-05-18" version="1">MTLEIGDSETMADRLVGKKLYETQVSNHSSTKYQQPIKAYPTSERNERKSALEMHTISFFPGSTSAEAQSYPCRPCSSLEQQNRKYNTKLKTNGGSNKEGGDCAVPLKSPIQRIGQTYPSSTIQNLWFFFLSCYVGLWIFPGPEERTFSLSRVSLTGLLARGTGTDWVDSAESAILTKTYGSFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG73</accession>
    <name>D4DG73_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019752.1">
        <property type="nucleotide sequence ID" value="XM_003019706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG73"/>
    <dbReference type="GeneID" id="9583686"/>
    <dbReference type="KEGG" id="tve:TRV_06175"/>
    <dbReference type="HOGENOM" id="CLU_2470697_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="88" mass="9820" checksum="0EF530A7A867EB3A" modified="2010-05-18" version="1">MGRALYLQMRNKSRGSNFCKKEGKRNIREAIIQCNGKSNKRPGLQNNSTTSKPLEEEVEEEEEEAKELDPHPTPSSSSAKGEAHGYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGF7</accession>
    <name>D4DGF7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000354">
        <property type="protein sequence ID" value="EFE39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019718.1">
        <property type="nucleotide sequence ID" value="XM_003019672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGF7"/>
    <dbReference type="GeneID" id="9583617"/>
    <dbReference type="KEGG" id="tve:TRV_06261"/>
    <dbReference type="HOGENOM" id="CLU_1582464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="169" mass="19258" checksum="43FFAAFB6CE1062B" modified="2010-05-18" version="1" fragment="single">RQSQERKRAESIAEQAASQQADRQTDRQDEIHRDEKETVKEGGKAAKKKQWSMKNIFPYMQKYIDSESREELSNECSFIVICIYFLRTYGVAAAGSLSLTPLSPRPDGFTLGFLRGPNDPERRGRTGKEAIEAHAGTPASCENYTENIRTLSVRIQAYRHSPQAQYQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGN0</accession>
    <name>D4DGN0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019617.1">
        <property type="nucleotide sequence ID" value="XM_003019571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGN0"/>
    <dbReference type="GeneID" id="9580146"/>
    <dbReference type="KEGG" id="tve:TRV_06335"/>
    <dbReference type="HOGENOM" id="CLU_013935_0_0_1"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="452" mass="50712" checksum="AC50BE9EE530EA7F" modified="2010-05-18" version="1">MTYTEKHAEYGGLNTGDERTKVIVDVGDVDDDAARWWAAVLSPGEGWQASLTWEGAIVRSPWSTSLEAVEQYTLSCYTPLYRVPTPVPSFTTAARFLAEYCNLHNIVDQAVAALSSVLFLPMLNSKKNPVSLPRPFFHEKPSPRSAMPETKEPKQCGFILDQIMPELDRLLTLSCNTRGLLSLLSSVFYEPGIPCNIVSPWTQATFAVLDSVEGSHLLGYILMNRVPQVSFLWLGGIITGTQKNILREGRYGITSIEPHAASWCSVTQSFIQAPVSQPLITNGALSRSDECRLLYLSQAELNRGWPLVPWMPFGTTVLEDAEIEVRLHTQCTGHELQYADWYWACRDSKRVHPICLTTTMSTFTLTEDLPINIPISYEALNLENESASQHATRNIFIWLRNNEFSAREQGIRNHDWVAFDESDDDSLLSKESSRSDKASVLKAVEDWILNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP0</accession>
    <name>D4DGP0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06345</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019627.1">
        <property type="nucleotide sequence ID" value="XM_003019581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP0"/>
    <dbReference type="GeneID" id="9580157"/>
    <dbReference type="KEGG" id="tve:TRV_06345"/>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="377" mass="42411" checksum="E8620D70FC5F36E4" modified="2010-05-18" version="1">MSSSQLEAENHERDAAFNKVLHGNTSKAQGGLAAMMGKDKKAQQAAVDEYFKHWDKKPSADETEETREARRAEYATLTRHYYNLATDFYEYGWGSSFHFCRFAYGEPFRQAIARHEHYLAHSIGLKENQLVLDVGCGVGGPAREIAKFAGVNIVGLNNNDYQIERATRYAEKEGLSKQLRFVKGDFMQMSFEPNTFDAVYAIEATVHAPSLEGVYSQIFKVLKPGGVFGVYEWVMTDQYDNDNPVHREIRLGIEQGDGISNMVKESVAVEAMKAAGFELLKVEDLANRPDPSPWYYPLAGSWKHMSSIGDLFTIMRMTWWGRSIVHRVLGSMEKFGLFPQGSQKTGDSLAYAADCLVKGGEMKLFTPMFLMVGKKPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGR3</accession>
    <name>CHO2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="1">PE methyltransferase</shortName>
            <shortName evidence="1">PEAMT</shortName>
            <shortName evidence="1">PEMT</shortName>
            <ecNumber evidence="1">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHO2</name>
        <name type="ORF">TRV_06368</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000362">
        <property type="protein sequence ID" value="EFE38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019609.1">
        <property type="nucleotide sequence ID" value="XM_003019563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGR3"/>
    <dbReference type="SMR" id="D4DGR3"/>
    <dbReference type="GeneID" id="9578381"/>
    <dbReference type="KEGG" id="tve:TRV_06368"/>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000405920" description="Phosphatidylethanolamine N-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="212"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="486"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="509"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="589"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="976" mass="109544" checksum="2DCCD61F34DC4D5F" modified="2010-05-18" version="1">MARLSGVERPDDSGLRERKARAVEEPVKQPVESADGAAAAAQAKKKTIGRTPDGTAFTVPHTRDMVSQLLSPSEPKNLSDILVLSIIGLHIVLLYLLPSFLRIPIFAVLFLSWRAAYNIGIGWLLHMQSNHSTMVLWARQTKIFVNPATGDNPHPQLYSFIKRELETKIPEDYSFEDAPIEYNTWLVFRRVVDLILMCDFTSYCLFAIACGSRPAEENFLVLILRWVVGLGLVLFNLWVKLDAHRVVKDFAWYWGDFFYLVDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISILAHAAQFAFLVLVENPHIEKTYNAPPPRKRTIESHAGLAGEEKSSRRPSDSSEMVPPPSPVALPSSTHNLVGVKNLDLHRITDSSIILIQVLFFALTMLTPSTPIYQFFFVLNAAIWRLWYSVGIGYILNCQSHRREWTRHFVKFGETKEEAWNQWKGTYHLSMTLCYASFIAAAWKMYTLPENWGYGLAILKHVLGAGLIALQIWTSVSIYDSLGEFGWFFGDFFFDEAPKLTYSGIYRFLNNPERVLGLAGVWGAALITSSRAMIFLALLSHTLGIAFIQLVERPHMQKLYGRGLRQDAGLVRSIKRSLPPSFKQLHGSVDRILDESIEFIEEVLDTARPKLAAGVTTFVKDTSELFHKYPARITITRIEPDLAGYDMNDYSINVDTSDCITIRDGAEDKSEVLVFEYGSPIKVNWTAPLNHSKRDWVGLYMIGQNPSREVTNVSSWGRWVATNHGSFDSVLSEKGLIASDVVVSKPGTSNTSKKPSVKSGSGKKSSTSTSSHEVASGQMVFSGDKLWWTQGVFEFRYHHNGKHNVMATSRPFEIRIPKFDDGQIPSHVSSNGNGFMTTAIEQALLPIVQNCFDRDPEISPQTAEEPFGCETEGDLKYAKRVVYAVHQMFGIEFATEVVRADGNVQNLAWRICNAKKVLAPYSMRKSNGASTPTGESEEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHM3</accession>
    <name>D4DHM3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019275.1">
        <property type="nucleotide sequence ID" value="XM_003019229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHM3"/>
    <dbReference type="GeneID" id="9577516"/>
    <dbReference type="KEGG" id="tve:TRV_06679"/>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="938" mass="105884" checksum="072BAF93324E6EA4" modified="2010-05-18" version="1">MSGRKDFLSQPAPENYVAGLGRGATGFTTRSDLGPAREGPTPEQIQETLAKRAALLGTAPPTAYGASTRGEKGGKADKEEEDDDRYQDPENETGLFAYGQYDRDDDEADQVYQAVDEKMDKRRKARREARERQEMEEYERKNPKIQQQFADLKRSLASVSDEDWANIPEVGDLTGKNRRARQNMRQRFYAVPDSVIANARDSTEFSTTINDDGTESYVPRGENADGTITNFADIGAARDKVLQVRLDQAAEGSNGDVASGSATSIDPKGYLTSLTKSEMKAGEVEIGDIKRVRTLLESVTKTNPKHPPGWIAIARLEEIAGRIGAARNYIARGCELCPKSEDVWLENIRLNDNHNAKIIAANAIKNNDRSTRLWIEAMKLESDPRAKKNVLRQAILHVPQSVTIWKEAVNLEENPEDARLLLAKATEIIPLSVELWLALARLETPENAQKVLNAARKAVPTSRDIWIAAARLQEQMGTANKVNVMKRAVQSLARDSAMPKREEWIVEAEKCEEEDAILTCNAIIRETLGWGLDEDDDRKDIWMEDAKGSIARGKYETARAIYAYALRIFVNKKSVWLAAADLERNHGTKESLWQLLEKAVEACPRSEELWMQLAKEKWQAGEIDNTRRVLGRAFHQNPNNEDIWLAAVKLEADTNQIEQARELLSTARREAGTDRVWIKSVAYERQLGNRDHALDLVNQGLQLYPKADKLWMLKGQIYESDGQIQQAREAYGTGTRACPKSVPLWLLASRLEEKAGVVVKARSVLDRARLAVPKNAELWTESVRVERRANNLSQAKSLMSKALQEVPNSGLLWSESIWHLEPRTHRKPRSLEAIKKVDNDPILFVTVARIFWGERRLEKAMTWFEKAIVANSDLGDVWAWYYKFLLQHGTDEKREDVLTKCIATEPKHGEIWQTVSKDPANAHKTTEEILKITLNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU7</accession>
    <name>D4DHU7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019205.1">
        <property type="nucleotide sequence ID" value="XM_003019159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHU7"/>
    <dbReference type="GeneID" id="9577202"/>
    <dbReference type="KEGG" id="tve:TRV_06754"/>
    <dbReference type="HOGENOM" id="CLU_131598_0_0_1"/>
    <dbReference type="OrthoDB" id="4173583at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="13693" checksum="9EF2142C2515682D" modified="2010-05-18" version="1">MSSETSGGFSGGVSGGNQAGRAGTAGAGATDPTRAGGGAAKESVREMGQGVKSAAAGAHGFGERVRGSAGAFVDRAMNDPEGAAKNERVVREGQKEMHTGDFSHSTREKEGLPHSEREVNMQKGAGTAQPPPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI06</accession>
    <name>D4DI06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000391">
        <property type="protein sequence ID" value="EFE38519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019164.1">
        <property type="nucleotide sequence ID" value="XM_003019118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI06"/>
    <dbReference type="GeneID" id="9577160"/>
    <dbReference type="KEGG" id="tve:TRV_06813"/>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OrthoDB" id="4173525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="13">
        <location>
            <begin position="678"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="725" mass="80068" checksum="D5EC7AF60438F725" modified="2010-05-18" version="1" fragment="single">KGKKKMREVNFSIPSVNKAAVNITTTLYDRRALDCTSTLPLINSLNHLAYLTTSSDRIRDILTVDGGIEQLVCILKAGRSKDLMEMWKWNLAFQCVVNIGVRGSENVRTRVVEADMVPVIATILDNYIRVVDRIRASSSAAASTDPEASRSKQHKTAINTTTTTTTAAATTSIPTSSTSSRRDQPPRTSRASFYDHRSDQRNARRQAPPPSIEIPLPYAQDGPEHNTATTNTATTAATTATTAATEGRHNNLHTPIDVQPSPHIVLTSPPERTTFNHHHHHHHHQREGHRHRILQPLASATVATAATTTAATTTPTTDPFNPIRQARDVDRLPSALPGLQAGITSQPESPTTPLGAGAPQANISPLMPRIFHRRPSVRQQRSTSGDSDDADAQPEPDDNDIIMGEGDLETANVETAEQQPIVDLDSSGMDLEDINMRDRDAMLDDASTVNAPTQAAQAATSPANGHPPTHAHARQPNGHQAPGVFNNPYPFYLQNQNQNQHNQPSQSQSHPQSNPQSHSTSQPHSSRSGNPAGPTILAAMPRDEDVLLALQLLAYVSKYCNLRSYFQQTHLVPRLKIGKELEMLDEANPLPASTSSSSSGPSTSAPSGSNTTTSPQTAEEAQEEMEEYILPDDFNIFPLVEKFTVRHHTKDMQYWACVVMRNLCRKDDSRGGIRQCAYYKCGKWEEFQRQFAKCRRCRRTKYCSKECQKSAWVYHRHWCHSSPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI91</accession>
    <name>D4DI91_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019074.1">
        <property type="nucleotide sequence ID" value="XM_003019028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI91"/>
    <dbReference type="GeneID" id="9582560"/>
    <dbReference type="KEGG" id="tve:TRV_06899"/>
    <dbReference type="HOGENOM" id="CLU_100745_1_1_1"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="137" mass="15026" checksum="E2BA54000FAD7602" modified="2010-05-18" version="1">METNWAAEDTRSAMDGNADSADGAGHGDKLTEYSLIKLEGVEDSKAATFYSGKKVAFVYRAKREVRGSKIRVIWGKVTRPHGMLKHDFQHGEQKNGCVLDTDGLIGNSGVVRAQFRHNLPPKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIA5</accession>
    <name>D4DIA5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019088.1">
        <property type="nucleotide sequence ID" value="XM_003019042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIA5"/>
    <dbReference type="GeneID" id="9582574"/>
    <dbReference type="KEGG" id="tve:TRV_06913"/>
    <dbReference type="HOGENOM" id="CLU_1442034_0_0_1"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="175" mass="20763" checksum="561471EDD9E5CD2C" modified="2010-05-18" version="1">MDVVSKYPKVLSASRHKYRQLSPENAEEISSTKQTTPKQNLKHRENNKEEKELKTDEECFKVTMCFYSQKRFLCGDWAWGSFAAKCNHEYRMGETCGMKLVHNTENIQAICKLCEKIQTKHRRRNTEVERINRWRREGSVMKASMEKSQAMVKDFEQEISQLEHERQLKQRSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIB8</accession>
    <name>D4DIB8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000403">
        <property type="protein sequence ID" value="EFE38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019048.1">
        <property type="nucleotide sequence ID" value="XM_003019002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIB8"/>
    <dbReference type="GeneID" id="9582536"/>
    <dbReference type="KEGG" id="tve:TRV_06926"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="46579" checksum="E14CEBEF8A288B76" modified="2010-05-18" version="1">MEDRNLPVVSGAFATVLIIGAAPLDLGTTGLALAQGFKKAGIACTIFEKHKSLNALPRDWNMGLHWGAVALQGVLSCELWDQIETVHVDPSKPVPEKDVLKFINSSNGELMSEVHVSKFYRLRRSKLRSLLDDDLDIQYNKALKDITMSRDGRTATVHFEDGTSSTGQFVIAADGARSTARQLLLGKKRGAIRRLPYAATFVHARFTAEQALYLRSFHPLYIAGIHPSGYFSFFGMHDAEDPDRPETWTFFFYISWKYSLEEQDRTSSWSNKQRLDQVKSFAKDFCDPWKSAFEWIPDDHQVWYMGLTDFDPGSDGHYWNNHGGRVTLAGDAAHAMTYQRGQGLNHSVTDAAKLVNAVTDAVSGLSSQATSISAYEDEMIARAGTEVRLSTVNTEMLHDWERVLASPVLTSGMKHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ16</accession>
    <name>D4DJ16_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_07181</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000419">
        <property type="protein sequence ID" value="EFE38155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018800.1">
        <property type="nucleotide sequence ID" value="XM_003018754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ16"/>
    <dbReference type="GeneID" id="9581199"/>
    <dbReference type="KEGG" id="tve:TRV_07181"/>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="363"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="49293" checksum="37009766FFFE3458" modified="2010-05-18" version="1">MNREKQGERKEEEEAAKKDKDGEEEAKQKTDRAEGVAIGRGTNSLITWSEQEGDPSLPSFGKDINKKNREKWLPLRSKCLAHPPISGPDSMLLVSSGQSGFNKSLILEYHCCQAFYPGLALSIFLELRVTTKAPSSPSSSSLRLNCGITYEGENPDEVSLDPEVNLITRVALYVLRCHNHHAFPVECHVHIKNPIPLGRGLGSSGAAVTAGVVLGNEVGKLGLDKARMLDYCLMIERHPDNVAAALYGGFVGTYLNELKPEDLAWKEIPLSEVLPAPAGGVDTGIKPPEPPVGIGHYKKFPWAKEIKAIAIIPEFELPTAKAREVLPQTYSRADVIYNLQRATLLPSALGQSPLDPDMIYLAMQDKVHQPYRKHLVPGLTEILSSMNPTTQPGLLGICLSGAGPTILALATENFTQIAERIIKTFEANNVRCNWKVLEPADDGATVVYHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJB8</accession>
    <name>D4DJB8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000433">
        <property type="protein sequence ID" value="EFE38051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018696.1">
        <property type="nucleotide sequence ID" value="XM_003018650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJB8"/>
    <dbReference type="GeneID" id="9580852"/>
    <dbReference type="KEGG" id="tve:TRV_07284"/>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="212" mass="24153" checksum="5BBC46EA697C0010" modified="2010-05-18" version="1">MSSKAARIGEEYNCLPLVPRAKDLAQTHANLKFRIWKTKVDKVNAELVTLTYGTVVAQLCADYESDYLEVNRQLDKMGYNIGMRLIEDFLARSGMGRCTNFRETADIISKVGFKVFLNITPTVTNWTSDNKQFSLVFEENPLADFVELPDDGRAQDELWYSNILCGVLRGALEMVQVQVEAHFVSDILRGNDTTEMRVTLVRYLEDELPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJG8</accession>
    <name>D4DJG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07334</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018646.1">
        <property type="nucleotide sequence ID" value="XM_003018600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJG8"/>
    <dbReference type="MEROPS" id="C85.007"/>
    <dbReference type="GeneID" id="9580797"/>
    <dbReference type="KEGG" id="tve:TRV_07334"/>
    <dbReference type="HOGENOM" id="CLU_049327_0_0_1"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="124"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="333" mass="36602" checksum="2BD34AE4B5C4086C" modified="2010-05-18" version="1">MRLRIRGPNGQSTVTLEDTATVEELLDNISRATSLSSYDIKYGYPPQSLLLSQFDAKSKIKDIGVNLNGEQLIVSKREEPAPQPEPSSEQERIEPAAPLSLTKKKSSIEDNAPEIPSPEHGGTIVLRVMPDDNSCLFRAVGSAVLGAIDTMTELRSIVAQSIQEQPDFYTAAVLEKAPDDYCRWIQTEDAWGGGIELGVLSKHFDIEICSIDVQTLRIDRFNEGCPTRCIVVYSGIHYDTVALSPSDEPYTHAYAPPEFDTRIFDSSDPIILEKAIELCQILNEKHYYTDTTNFQVKCNVCGGLFVGEKGATAHASETGHYDFGEAGYSGGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK02</accession>
    <name>D4DK02_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Disrupter of telomere silencing protein Dot5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000447">
        <property type="protein sequence ID" value="EFE37824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018469.1">
        <property type="nucleotide sequence ID" value="XM_003018423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK02"/>
    <dbReference type="GeneID" id="9584396"/>
    <dbReference type="KEGG" id="tve:TRV_07522"/>
    <dbReference type="HOGENOM" id="CLU_1338394_0_0_1"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="7">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="205" mass="22562" checksum="2671CBDA71A10F8E" modified="2010-05-18" version="1">MFVYNNIGTRQACAFRDDYANLTSTGLSIFGLSGDSPKANTTFQTKQKLPYPLLCDPFFKLIGAFGLKKTPKGTVRGVFAVNKEGKVLLRTPGGPEKTLNLVQDLVKGKDLSRSLPVLCRGGGALVGAEVTLHQKKKKKKKKKKTKLAKRKRRTKRKKTEEEESWSLEQSCIFVAGAKRALASAHLYNPVVDRDPPSANLQAAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK25</accession>
    <name>D4DK25_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018446.1">
        <property type="nucleotide sequence ID" value="XM_003018400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK25"/>
    <dbReference type="GeneID" id="9584376"/>
    <dbReference type="KEGG" id="tve:TRV_07546"/>
    <dbReference type="HOGENOM" id="CLU_001011_1_1_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2428" evidence="2">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="897" mass="99186" checksum="7F24DA205ED1FEB5" modified="2010-05-18" version="1">MKYSSMDDILTAISLLLNAILSNTSFAPLGTQEGLNYDEFARVGSLTFSQLAELRHRGAFSAVSQTFVSCCQRCSVSKDNAVAELPQTWFKEILSTIYGQSAKLTRRSAGLPALALGVASSAKRPFFHEIMEKLQDIAKIPPTSVSEQVDVKLPQVHAMNCLKDIFTATNLATVTEEYLMPALSISAECLGSEIFPGLIPLLTGLLEKGAAKGSSDNTLSEQLSITTERVFPALELIGNKFPSPATSEDERILESVSWQFDSPVWGIRDHAARTYATLVDRDDILSVILKLSKTSIQGQNQLHGIALCIKYLLRRICAAPVAYYQCKRSITLFDIHSTKYLLALLPAVVSTTEPMFTNLGRHVSSPFTLRELVEIINDLLQSGMTKGTEDTIVDHFDAISTILHLDKHYQNIIYNPKPGSPMERSSSLLLESIAFSYLMTGALLKSPVDDLAQFIQTVSLVDADIAASILGRFSMVSLGHLSSRSDRLKLYFRIITDGLSKDTRLIAISSLSDELEAIQESAEESHAAFRELDFLVSWSSTLPISESPGEPLWGRKMTDATIRLQGCLLSLHIRQSPSILSSDSTFIERFNKLVQQLSVSMRDETVSAIYMLLSLRAAKIQFPVTPILIDVMFVLYDMLNDDDVEIREAATLVASKALADDLMVFRLPAASASAIADLLTRQYPGSSGVFEGALQRFLGAPSQRRLFVPVAETLNKAINESTALFAEEKQNLYIDEVREIKLWGQHLIQLEKGAINCSLYGHFSTWVMDGLDSLIQLAADKSKDSLLGWTSNTDVFVIGIRILYGAKVLLLTHRSVSIDVNTIELTHKLQALYTCTYTSELNPAWSSLLEGGVNNMNILIEYSFSFFSDSYPLIFIHHKGLIYRLSTSGEVNRTPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK43</accession>
    <name>D4DK43_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018436.1">
        <property type="nucleotide sequence ID" value="XM_003018390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK43"/>
    <dbReference type="GeneID" id="9584365"/>
    <dbReference type="KEGG" id="tve:TRV_07564"/>
    <dbReference type="HOGENOM" id="CLU_125044_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="14089" checksum="DE0A69B9DF0F0982" modified="2010-05-18" version="1">MVSAIRTSARSLRDYILKTKSRTINFAKGQGTPGHRFAPQQTGTNDASIGSRLDNGDIITKDGTQYKRYKFQLNKNAQNSTLKDEARKDSHKVWAQVDVQIKENPTLEESKSTVVEAFDTIEGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKC9</accession>
    <name>D4DKC9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-ketoacyl-acyl carrier protein reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000466">
        <property type="protein sequence ID" value="EFE37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018333.1">
        <property type="nucleotide sequence ID" value="XM_003018287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKC9"/>
    <dbReference type="GeneID" id="9580035"/>
    <dbReference type="KEGG" id="tve:TRV_07651"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="204" mass="22069" checksum="B08C4A3BD047F3B9" modified="2010-05-18" version="1">MATAMGKRLDGKTILVTGASSGIGKATALEFARTSPKNLKLILTARRFDSLKQVAEQIKTEVGEGVKVLPVQLDVSKKENIDKFIVELPEEFKEIDILVNNAGVAKAPEIATEDLEVMFNTNVHGLIHMTQAVLPIFQKRPNGGRGDIINLGSIAGREAYPGGSIYCATKAAVRSFTDALRKELIATRIRVIEIDPGQVETVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE6</accession>
    <name>D4DKE6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018323.1">
        <property type="nucleotide sequence ID" value="XM_003018277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKE6"/>
    <dbReference type="GeneID" id="9580025"/>
    <dbReference type="KEGG" id="tve:TRV_07668"/>
    <dbReference type="HOGENOM" id="CLU_004312_0_1_1"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="443"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="858"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116342" checksum="F26255E2930B15A9" modified="2010-05-18" version="1">MLAFAGADEKAEGSWRVDYLVIEQPPSPRALSQRSSFPQTMPALSSPDTPDSHQQQQHNQHTPGTKQASSLFAHPASKQPHEKAAANAFLWNPDFNNGDTGDGVTASANFFVDSRSRGPNSKAGATVSISPSRDQDRERDRTESVDSSLRNGRAVSSRNSMADNATTTTPTTTTNGASAHNEAYEAFADEHERWMNGTGQAQGQQGTINGAALPYRPSSKPSTTTNYQASQLHNYTGYPSTAELTPPSSSSQHEDAGPAPTRPPPPIPTTATTTTTTTTTTTTSVSKPTTPTPKPTTLDTNNLAPEPQPITYRHSSPAPQASSNAHSEIPTFPSSPPGGRLIHRHTLQVPRHSSSRASRELSTPIAVDDTLLPIDRVSSPTSVLRRGSFTIPRLSQRSNHSEPHLDEALHDEGAARWTEAFKQRRASKRKRREEEDDDRVIVGTKVDQHHVNWVTAYNMLTGIRFTVSRTNAKLDRDLTDADFDAKHKFSFDITGNELTPSAKYDFKFKDYAPWVFRRLRAKFQLDPADYLMSLTSKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHAEHKLLRRILREYYAHIENNPNTLISQFYGLHRVKMAYGRKIHFVVMNNLFPPHRDIHQMYDLKGSTIGRDFKEEDLVANPRATLKDLNWLRRNRHINCGKEKREVFLAQLRRDVSLLQRLKIMDYSLLIGIHDVEKGNEEKLRDRTLQIFQPGGDLADEQQPNLLMRTPSRLENARKARELREMIKREKPVPMEHTTAKMPDEVLDERKNLVFYSDDGGFRATNENGDPGNEIYYLGVIDCLTHYGMVKKAEHFWKGLSHNSSQISPIPPQAYGERFLEFITSITKSKDQVEREKQTAEAAQTHTTDEAASSAEKKSTDAQKSQSAHPEPSRTLKTVSTPADFNNGGAAATLPVVEEVGENSSTGGRSGRSNVSRGGEGDGAPADEERWTSMESRRHSFRTAREPASPPPVSAPPPIPSPKIGDGEYKPHTHLGNPTDSNGTIRAVRNSSERDKELPPTPDRPPMPQRRPPPTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKG9</accession>
    <name>D4DKG9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018312.1">
        <property type="nucleotide sequence ID" value="XM_003018266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKG9"/>
    <dbReference type="GeneID" id="9580008"/>
    <dbReference type="KEGG" id="tve:TRV_07691"/>
    <dbReference type="HOGENOM" id="CLU_017395_1_0_1"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="42758" checksum="B5B4DC34D1DB4171" modified="2010-05-18" version="1" fragment="single">IGDRHFQIPRDIFSSPGDSPNFFSLGFAVFFASPTAVFPGLEREGLLRPPSITPPIVSSRSGDVFAELLHLLRGYPVHIRDEEHRACLLRDCRYYHLRGLEQKLIPHDISYNLERRRFEITVRLEDVRPSGITFVPDGEGSSNPNANSTITGGWIHYARPFVDDDHRELIIEIGGGNTLVDLTTMRAELHGLAKARVTSLCQVISNKMNLPTNTPLSLTVTPGNSSSSNNSPANGSNTALTGDRIKIHIDSSTDITLDGEPFSPNNNYDTTSNGSNNSTFQPAEAPAGYSPMEGNAPPLTPSGLYPRLQTPSAAAVQPNQQLPRKRRRVDGSERSRQWVVDRGQWRLRVHPSTNASTGTSQMEVVFVAVKLEAHSSQRARNARRSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKH2</accession>
    <name>D4DKH2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000469">
        <property type="protein sequence ID" value="EFE37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018290.1">
        <property type="nucleotide sequence ID" value="XM_003018244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKH2"/>
    <dbReference type="GeneID" id="9579986"/>
    <dbReference type="KEGG" id="tve:TRV_07694"/>
    <dbReference type="HOGENOM" id="CLU_677870_0_0_1"/>
    <dbReference type="OrthoDB" id="4851482at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="406" mass="45627" checksum="AEE5E4E1FC4F8941" modified="2010-05-18" version="1">MNHSYVFGGEDMSKFASDDVAGLMALHNYAYDIDQSGPSHDQGGAVDGEESTELEFKAENQTNAVDAEGGQEIVEQGQEQQEHQTTDNNLFEFDDLFNLTGSPDRMCDADLAPKNPQTHNFENAQASSFSEVAYNTSPVQSSKQFRTPQSATTDGTGELKQSPHDHNADLDTENVDDRTFYEAFAAYTAGPQVEPPQPYPNQNNMNPGVTQDLQTATGHSTSNVYSSSPPYDQAPGNPAIARPALMTWSLQNDPSRNDGPVEIKDERQNYKDPSDTVTLQFSSSKEANDYRPDRRPMPFDPTIPRTTYERQECVIKLIKAMRSFECATDNWGMIKPFATKKFSDRKIEICCWNILDCCIVRQEAGPFLTPEEEALKNKTRKNKQNFAERFGDMLRILRVRYFFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL88</accession>
    <name>D4DL88_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000495">
        <property type="protein sequence ID" value="EFE37393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018038.1">
        <property type="nucleotide sequence ID" value="XM_003017992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL88"/>
    <dbReference type="GeneID" id="9579166"/>
    <dbReference type="KEGG" id="tve:TRV_07962"/>
    <dbReference type="HOGENOM" id="CLU_1190626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="233" mass="25732" checksum="37481E0FD4C4264C" modified="2010-05-18" version="1">MVTIREPARAHHVYPNGGRISGRQASSPKQTTLEYAALVRAFTTRMRRNIGTLVMEYPYARNTYWQITAKDEPLRENREPVAAQADANTPAAEEWAIPTSQREEGTPQQPTSGLEILATTQSQETVMVTENVTDVETTEPAPAEATPAQQPIYALEDMHGEFDIPDADEGLANLANVTVYWPNDPGTVGSAPTSMATNTQTARGNIYKACRCPEHQEIYDNWPARHADLTIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLA3</accession>
    <name>D4DLA3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter protein smf2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000498">
        <property type="protein sequence ID" value="EFE37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018014.1">
        <property type="nucleotide sequence ID" value="XM_003017968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLA3"/>
    <dbReference type="GeneID" id="9579143"/>
    <dbReference type="KEGG" id="tve:TRV_07977"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_1_1"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="60980" checksum="0DBC802C5576C58A" modified="2010-05-18" version="1">MNKTSRTDEPYEGDGYNQNPNPLSNDLVTNEALNGIVNSRELKREEPQSLHGETQNVDRDKNANTHPATGSGEASNSLASPLTGQLPRGDNKLPLSQIATVTPDNEAAGPSGPENSRDSLIERVKKVLLKFCTFIGPGFMVSVAYIDPGNYSTGIAAGASYRFRLLFVILMANLFAILLQSLAIKLGTVSGLNLAEACRAFLPRWLNILLYVLAEVAIIATDIAEVIGFAIGLNLLIPKIPLIVGCAISIFDVMIILFFYRPDGSMKALRAFEAVIIIYQACGILGATVMPHSLYLGSGIVQPRLREYDAKSKLLPPELLSASSSVNEGVDKDKLHYIPSIRAIRHSLKISIAELTVSLFSFALFVNSAILIVAGASLYKNKDALEADIFGIHALLSKSISPAVGTIFALALLLSGISAGVICTIAGQMVSEGALNWKLRPWLRRLVTRSISIVPSIIIAAAVGRQGLNATLNASQVVLSIVLPFITAPLIYFTCLNKYMTVQPGSARCLAPNEGIFRNNRQVVGAAHQGESIIKMANSWYIAVVAGLVWLFITVMNVANLVLLGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC1</accession>
    <name>D4DLC1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017991.1">
        <property type="nucleotide sequence ID" value="XM_003017945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC1"/>
    <dbReference type="GeneID" id="9579119"/>
    <dbReference type="KEGG" id="tve:TRV_07995"/>
    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="220" mass="24526" checksum="3FF0A900D653ACE8" modified="2010-05-18" version="1">MKIITKEIEDAHHKAVLQGVTIGGIAGLIGGWAGVLVASKRWAGVRNLTLPMKAFLVTSTGTFTGIVAADHGSRSFEKSQRQDIEFLEDRESRLRKEELAQMSVRDRIFEFARQEKYKIVGLTWLASMFGSFALVSRSPYLTGPQKIVQARVYAQGLTLAVLCATAAFEISDQRKGRGIADAVRAKAKKDKNTNDDLWKDMVDAEEHRIHDKEEAKVKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLD4</accession>
    <name>D4DLD4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018004.1">
        <property type="nucleotide sequence ID" value="XM_003017958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLD4"/>
    <dbReference type="GeneID" id="9579132"/>
    <dbReference type="KEGG" id="tve:TRV_08008"/>
    <dbReference type="HOGENOM" id="CLU_006240_2_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="254"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="908" mass="100033" checksum="11C61ECD6018FBA3" modified="2010-05-18" version="1">MATCLPLLTTSKVPSRGSWDDSHDSFPPSKRLKLDNDSDGAVALIPRSRIPLSWLDTCLSSPRRIRPGSLFTANIPALEQSLSGENVSSVLAAAISDTVERHYGEVPKEYYVVERVKRYVYAICPLRGVVQEGDLAVASKSSGVQEEFGPVQSPSDPFTDSLEFATIPDIDLFQEIPAQAVSFAFGDSPHEDPVSSQVDKTETSPNAALQSPAVATEVSPKEGDNIELGFSLPAEYFADSQFLPQTNTGNNAEDMLSTLKMQYLEALYISKTSVAYFAKGPLTRARAAFQNPDDASSMRPTVLYHYYRSCIIPMKKMDAKYRDSLPRIVADITRSQSDGDKIAPTKKRKGKKKTIGKDGLYAGEEEFISKWWKSAYETNSLVEKSALETQRKRLIEDIRMRETQLQILLILEIMLLEGSVGSPAELDDGNTEKPKKAIKKTHDMATALELLLDRLCIWHTVSSHDFAISVNSAKAATGPGKPNNDKLRDFCTEVIIPFYSARLPEKCQVINRKLGGPAISSPARPNRSNQKRSTNPLSKSAKGQPSKRTLQRVRTDEKIPARAKVPSLARNNTAPAAAEVKRESNDQLSFSTSIGGRGDIQKSKRANNREVDLEAVAKQHESKLKRMNLLVDQKRELDAAINALRKPNRELAVRDFVESAEKRSASSAASHPRKQKNPTRNPFAQGVQVMATPKRPRNKDCGFTDLPSLPKAWKQSRPTVMASPIPGPDTQVVPSSSTRPSNSDMLPKSQPILNFSRTEDLVHETPSKPSSNGLKQSATSNPVESGIEAELSPILARTSKPCSYKSSSIKFGLDTSAHSTSAEVGETPPRPKQMMFVSESTVPRRVDFMQPSTPAQGSVQHNIPVSTPLRQRAGDDANRTINETPEKSIYERLGWNNDDDDDDELAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLP5</accession>
    <name>D4DLP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_08119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017863.1">
        <property type="nucleotide sequence ID" value="XM_003017817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLP5"/>
    <dbReference type="GeneID" id="9583758"/>
    <dbReference type="KEGG" id="tve:TRV_08119"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="15121" checksum="7D8B5768DD6B6395" modified="2010-05-18" version="1">MDNTNPTLPLATVQKIITEILPPSSGQTFAKDARDLLIECCVEFITLISSEANEISEKEAKKTIACEHIERALTDLGFGDYVPDVLAIAEEHKEQLKTREKRTNKIDQSGMSHEELLRLQQELFRSAGEKYNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZD5</accession>
    <name>D4CZD5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025654.1">
        <property type="nucleotide sequence ID" value="XM_003025608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZD5"/>
    <dbReference type="GeneID" id="9581893"/>
    <dbReference type="KEGG" id="tve:TRV_00177"/>
    <dbReference type="HOGENOM" id="CLU_026584_0_0_1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="304" mass="33603" checksum="C7B9BF1A235DD816" modified="2010-05-18" version="1">MAQTNPAQMPPSPQSSTKRPSFDADGASPAKRQRRSYRRHHCLQRSHDLLAAGAETLNDSTSIDAQLNASIARVLDEAGFDNVEPVVLDSFRNNVEEHSLQPHLKAFPRRMQPTTTTTPSSKPSLPTPPPEGADDEDKPIPARNYAFLGPELNSGVGDLKKASYIPKNFPSFPSKHTYQETPVFATKREINPEKIRERATEEGRLGEEALRKLTRAAREGQGSGRAHRDKLLWGRKNESMDSMFDKTLKALAKSTSASKQADGSLVLDLGPIVNSNRVYWRKPSAPATRPDPQRMTMAAAREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZV2</accession>
    <name>D4CZV2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025476.1">
        <property type="nucleotide sequence ID" value="XM_003025430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZV2"/>
    <dbReference type="GeneID" id="9581712"/>
    <dbReference type="KEGG" id="tve:TRV_00345"/>
    <dbReference type="HOGENOM" id="CLU_1760120_0_0_1"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="148" mass="16530" checksum="938E1B75960BC61C" modified="2010-05-18" version="1">MKGNERKIWLANSIYTTGKQIILLQASLALVQNPTAYAQPLKPDPFERLPYDSAALKGLEVLSQNTRSQLTRKKEMSALARHYGVNEVMRWVPRMQHDLTESGVDTIYTHAMYAIIGAIALEHGSKVANEIVRDRILKPLGFQIGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY7</accession>
    <name>D4CZY7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025441.1">
        <property type="nucleotide sequence ID" value="XM_003025395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY7"/>
    <dbReference type="GeneID" id="9581667"/>
    <dbReference type="KEGG" id="tve:TRV_00381"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="262"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="434" mass="49371" checksum="9CB88B35F8C9828D" modified="2010-05-18" version="1">MEQNSPASVVKKVCYHALHRCMAYMYASLKFIDHIPCIDATLAQFLCCVGGVYQSKLVPQETPPRYPSKMTKEYVEPANIPVIDFRALTSENPQERKDALNQLDEAFQTYGFIYLSNHSIGQKLVDEAFSWSRRFFHLPDETKALCKHQTVAADHRGWAAVGTGFVSQDVWDKDEIEKLRKTAPIEQKEILEMGNPHSKGDPGESIVNRLLPEDVFPGFRAFIEKWWDACFKQQLQVLRALCEILEYTDLDYLGKQQDPSRSRNHMSWLYYLSQPVAPLRSGESNRLNTHTDFTQLTLLFQDMVGGLEVHDYNAGIFRPVLPKPGTMIVHVGDMLEKQSNGKWKSALHHVSAPSHLKYGDEKTNEDTVVERFFMSFYGTPQHDVMIEPIPGCEAAGKWQTLQWEPNMTAGAWIQKRVALEYGDGQQAPQVVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D022</accession>
    <name>D4D022_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025355.1">
        <property type="nucleotide sequence ID" value="XM_003025309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D022"/>
    <dbReference type="GeneID" id="9581648"/>
    <dbReference type="KEGG" id="tve:TRV_00416"/>
    <dbReference type="HOGENOM" id="CLU_047421_2_1_1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="386" mass="44512" checksum="AFD11C8EE44DEFB2" modified="2010-05-18" version="1">MAATLPRRSRPAIDQGHERLIYSNTSLLHGHPPVIKTRAQLSLEENLQANVPQSQAAARPAQISNPKFRETRPRLLLMGLRRSGKSSIQSVVFHKMPPTETLFLESTTRIQKDAIHSFMDFQIWDFPGQLEYLEPSFDQEELFSNLGALVWVIDAQDDYLEAVTRLNKTILMIQQYYPHINIEVFIHKVDGLSEEYRSDTFQDIVQRISDELSDAGYENAPIHYYLTSIYDYSVFEAFSKVIQKLIPQLSTLENLINILSNNSGMEKTYLFDVLSKIYIASDTRPVDMACYEMCSDYIDVIVDISELYSWDHPDRKAKGPQVSEAESHVILHDKCMIHLMEMNKYLCLVSVIKNPDAKEKKGLIDMNCRTFQDALNEVFSRTWDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0A6</accession>
    <name>D4D0A6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025321.1">
        <property type="nucleotide sequence ID" value="XM_003025275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582927"/>
    <dbReference type="KEGG" id="tve:TRV_00501"/>
    <dbReference type="HOGENOM" id="CLU_000688_15_1_1"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="578"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="834" mass="91019" checksum="9B4F705B2BB6B082" modified="2010-05-18" version="1">MRPKASSSMQKTYDDCYLMCSTAVYFENQNNESEALRTWKAALDALYYHNAHKVPSTYIPKNDIERGLQDSLRELELQCKERVMLLETLRESRKEAGMDVDVKAASTQKGKLEKPRPQVNGSQSSISSGHSGWIGEGTIPSLSYPDLPRPPALPPRSTTQSQSSLNSTIPAPLSSSGDVRGLGLDSLPSPPTLPVPAIPRDTNRVQNPEKKKTLLTTLRGKDLKSPTNSNTQPRKHSKPASKAAGLAWSFVTQSNSSKRGQTSPANESAPATPRKSTSSDSGSKRDVLPTRRSIDESSTPARASHRPDYFSGSPITRRISGDHTAASLAAGAAAAAAAAQRPMEAESSNSFLDSSPELKGGPSDKPKSTDKKNDSGYSPPQSKPPTSLKSSNTEPARSVPATQATLQSRSNKVTPDDVFQRKAVKSSNSAPSKPRSNVKDCRNVESRNSDFPPNGKMRQLNTQPSAPANRPAVGPKRTTSKSSEYSAEIPAQGDNIDDDIDLPEYEPEEDLVLKRALSNLPKGVDQESAKQIFKEIVVHGDEVHWDDVAGLELAKTALKEAVVYPFLRPDLFMGLREPARGMLLFGPPGTGKTMIARAVATESQSTFFSVSASSLASKWHGDSEKLVRALFGLAKALAPSIIFVDEIDALLSSRSRSSEAEVSRRIKTEFLIQWSDLQRAAAGREQNSKDKKMGDASRVLVLAATNMPWDIDDAARRRFVRRQYIPLPEPEVRKLQLQKLLSHQKHELSEADIDRLSSLTEGFSGSDITALAKDAAMGPLRNLGEDLLHIPMEKISPISFKDFEASLLSIRPSVNQDGLDRYDEWAKNFGERXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D118</accession>
    <name>D4D118_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025106.1">
        <property type="nucleotide sequence ID" value="XM_003025060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D118"/>
    <dbReference type="GeneID" id="9580598"/>
    <dbReference type="KEGG" id="tve:TRV_00764"/>
    <dbReference type="HOGENOM" id="CLU_046721_0_0_1"/>
    <dbReference type="OrthoDB" id="5387895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="52873" checksum="1147255DFB50F40E" modified="2010-05-18" version="1">MSSTRAGSQNQGQKPPYTTEESSDSESEEESSSSEGEVEEEEEEEENSPSYPVTFSGKSSIVYDLQMLSHSARAKARHGLSGDFSVDKCRPIYGGGYDFHVVDYGRVYVGEGPMACSCPDFQANNGASFSQWLVDQLHRRVLTSRPSGALKLSQNGECEKLGPMLKLIGNRMENICQKVEWPYIPTPGTPPDTQCSSMSMSRPEKARDLLSAFSADTMPDEFRPELVETIRQPRTPEQCVVQGDFEATMFRLAVHDENVYASLRKVMPSGARAAIFFDKVQRRIRSLLADFNRYRQKGTLRQSDHTALEVDVVADEMRDHLRLIQKNMFSRSPHGFKGAAETLLYLLRAVCQFNFDAFETSTWERPSESDEAAEDRNLYFQLIYNPVNGDDFFVLSCLEQLPEDILQQITPQLDNIFSDMQVNAAPVPYLRKLHSIIAGDIPTKTAVGAALIPGASGQKRPSTAASGSGRKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D127</accession>
    <name>D4D127_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025115.1">
        <property type="nucleotide sequence ID" value="XM_003025069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D127"/>
    <dbReference type="GeneID" id="9580607"/>
    <dbReference type="KEGG" id="tve:TRV_00773"/>
    <dbReference type="HOGENOM" id="CLU_052827_4_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="311" mass="35131" checksum="9506BFCAF0439A80" modified="2010-05-18" version="1">MTIDRPPYTEHWNSIAGELANFTEYWVYIFQLAELHRPSGCSDVDIQLHPRHIQPRLLRLRQPNKLVSRLKTRETEPSMTAPKPYTVPDATKAAFQANNWTSTLLKNNAYQPIETYCRKPKPQTGEDAFIATIINTPTTIPHLLTLQRKPGQLAKVPSGAPSLPAPPDQWPKIPSNQPADVVNLLYFGERDLNGHPGVVHGGIISTLLDELMAISVAAHIPDFDFADTSKFGQLFTMQLDVRFKRPVRTGAHAVLRTWCIGNEGRKWWVRAQLVQEENPIKPNGEKVEWVKKKYVCADAVGFFILVKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D171</accession>
    <name>D4D171_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025014.1">
        <property type="nucleotide sequence ID" value="XM_003024968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D171"/>
    <dbReference type="GeneID" id="9580506"/>
    <dbReference type="KEGG" id="tve:TRV_00819"/>
    <dbReference type="HOGENOM" id="CLU_032993_1_1_1"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33218" checksum="067D75BBE95A3D72" modified="2010-05-18" version="1">MSFPKDAVSPTTLSPRIAGLSVSPTELDTSGQPPPRSSHGMIQDEAVEDDSGHVSQNEAAEDTSALTHPPFKPLFTVIGDATSSEYFHPTVHYIFSDDDTSLITEAALRSLESNNQRTSSWSTESISQKDKKKGKSAPKTKAASEQFIILDMEPTYTNDNDTRAAGGEAKTTDAQETPVHPAPQVFQDFKVTSAHSLSPSWQVINTSLSPAPNFDSSSNSPTSTDRDGNTVLMIEGTSGLASDSTTVRQQTQQAPGQTLEEMMDQFARRMEELKKVVEASGEHSFSQVVTHAENQEDSPQPEEQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R0</accession>
    <name>D4D1R0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024838.1">
        <property type="nucleotide sequence ID" value="XM_003024792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R0"/>
    <dbReference type="GeneID" id="9580316"/>
    <dbReference type="KEGG" id="tve:TRV_01003"/>
    <dbReference type="HOGENOM" id="CLU_054095_2_1_1"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36378" checksum="038A6E0107C2873A" modified="2010-05-18" version="1">MSREGVESKAGAVTPVDGRQGFLEPRQLHVPETVLGGARRWNTRDLGSRLAVDVVSAATAGALICPMITIIDKSIIEKAAKGISIQSSLASSLKGMITKPHRFLTSTPFLLIYTLYSSTYLSANLIDTAVSTMEDKAYNNVSTGFMKFLTTAMVNMSICVYKDSRFVKIFGTQGQGNKPSSASAKAPTAAAVTPQIKAAAACLPQSAPKIPITSYGLFCFRDSITIFASFNLPPIVARYVPDAIASNPKSKYAIAQFAIPASIQLISTPFHLLGLDLYNRQPPGGLPAADRWARVKRDWVPSCIARIGRILPAYGVGGVVNTRMRERFMSSIDPGQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1V1</accession>
    <name>D4D1V1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024771.1">
        <property type="nucleotide sequence ID" value="XM_003024725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1V1"/>
    <dbReference type="GeneID" id="9580261"/>
    <dbReference type="KEGG" id="tve:TRV_01053"/>
    <dbReference type="HOGENOM" id="CLU_1876948_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="136" mass="15412" checksum="1FC731CD8FF4ED34" modified="2010-05-18" version="1">MCANNGRFSVFFCFVVGRKLRQEIQQSRGALASEDSKGFPKGHLWTSLVPFVPFLYEQVNMQRDAQRHRGRDAQPSGIQGSGYILPTLTTERDRRTAELHAEERSETRGIYAWDTSAGGTPYLLEAERGIRVRHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1W8</accession>
    <name>D4D1W8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024788.1">
        <property type="nucleotide sequence ID" value="XM_003024742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1W8"/>
    <dbReference type="GeneID" id="9580278"/>
    <dbReference type="KEGG" id="tve:TRV_01070"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="131"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="985" mass="109930" checksum="C90725C805608877" modified="2010-05-18" version="1">MDDLYDEFGNYIGGEESEEESQHGGVEAQQFDYDLESEVEAPAAHGQELMEIDDQGPSNAVILHEDKQYYPTAQQVYGADVETKVQEEDTQPLSQPIIAPVQQKKFAVQEADLPPVFYSREFMTDLLNYPSQTRNIALAGHLHHGKTAFMDTLVMETHDLSEKLDKRTGKSKDEQLRYTDVHFLERERGLSIKSAPMSLVLQGTKGKSHLFNIVDTPGHVNFVDEVAASLRLVDGVVLVVDVVEGVQINTEQIIKHAVLEDLPLTLIVNKLDRLILELKLPPTDAYFKLKHVVEEVNTVIERTIPGQGEKRRLSPEKGNVAFACASMNWCFTLQSFAKMYADTYAKVDLSEFAIRLWGDILFNPRSRKFTRKGMEEQSKRSFVHFILEPIYKLYSHTISESPEDLKDTLATLGINLKPSQLKSDAKVLLKLVCAQFFGPVTGFVDMVVQHIPSPVDGASKKLDRYYTGPRDTKVAAAMEACDQDGPLVVHVTKLYGTPDAAGFNAFGRIMSGTARAGQQVRVLGEGYTVDDNEDMVVATISDTFIAESRYNIPTSGVPAGNWVLLSGVDNSIIKTATLVSLKLEDDEEAYIFKPIKHMTESVFKVAVEPINPSELPKMLEGLRKVNKSYPLISTRVEESGEHIVLGTGELYMDCVLHDLRRLYAEMELKVSDPVTRFCETVVETSAIMCYSVTANTKNKITMIAEPLDDGISEDIESGRVNIHDPIRKVGQFFEEKYDWDKLAARSIWAFGPDDMGPNILQDDTLPSKVDKKLLGSVRDFIRQAFSWGTREGPLCEEPIRNTKFRLTDIQLADQAFSRGGGQIIPATRRVIYSSFLMASPRLMEPIYTCAMTGPPDSVAAIYTVLSRRRGHVLSDGPIAGTPLYSVRGLIPVIDSFGFETDLRIHTQGQATVSLVFDKWSVVPGDPLDRDIKLRPLEMASPMATARDFVLKTRRRKGLAEDITVSKFLEPELWKGLKESGILGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D241</accession>
    <name>D4D241_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HLH transcription factor (PalcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024680.1">
        <property type="nucleotide sequence ID" value="XM_003024634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D241"/>
    <dbReference type="GeneID" id="9582855"/>
    <dbReference type="KEGG" id="tve:TRV_01143"/>
    <dbReference type="HOGENOM" id="CLU_015973_0_0_1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="567"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="716" mass="77222" checksum="7CE8F06994EF2F03" modified="2010-05-18" version="1">MNQDPSLPSWPEHVPDEAAAAMIPTTAEDYTSLLDFNFDLAEFDGGNAGERQNQNMVTTAPPLVSTTGMQDISGLTSMEHINTSQPLQEQQQHYPTSVTMAGSEPVTPMEIQGSNSMQQQQQQQHFYMKQHHQQQQQQHSQNAYSSNYGQRQSFVPPTPDSADMHGGSHNYNLRLETGHQRGYEPFTRGLEDQSSFTPLMSPAMTPLEHQLRFPEYTTPGEYLSPLTSPALEARQSNGAGFNFPNGSHMDYGSMLSSPTDISHQHPATTGPLTNSPKLIQKQRRKSQASRLSRQSPLVRPQNGRSRPQTEAEARARAKKLSAQAAANRTSNSRNSSSNEGSGLDSVSPEPLTEPLMPPPALPRSGKSPYMGAQDQPTTMNEVATPATLMKLQKQQISPGMDGEFSRNGTVVVGSAPEEHMEDISLPEPASLQGAPSGESTPTIHAKLPHTIKPRTESISELKGTSSVTPSPVIRAKGSPSGPVGLKRSDSKQSSRVTKKRQGMSAAQSPALRPKISPSIQPLIRADGVSSETSALHLASKSNYQHILEGTLLPGVTYPEALAENLSSKRTNHKLAEQGRRNRINSALKEIESLLPTSLTHRAKEKEQNKDSADGSSTGVSKVPDKPSTNQPISKASTVEMAIVYIKALKQELEDTKAKLKAAESKSCNESPCHIPAQAPVPASDSGSNSLQISDAQVEKQDTMSGAPAADTNPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2I4</accession>
    <name>D4D2I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024577.1">
        <property type="nucleotide sequence ID" value="XM_003024531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2I4"/>
    <dbReference type="GeneID" id="9579901"/>
    <dbReference type="KEGG" id="tve:TRV_01289"/>
    <dbReference type="HOGENOM" id="CLU_054430_0_1_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="310" mass="35654" checksum="B4BC0639A1A13C43" modified="2010-05-18" version="1">MQNVNLQGAAYTWDAADERLWERLQNRRNAASGGKKYVLKNMIPGEFEYQLDLQRRFSGHPNIRAVTDTIQPLEMFIYPYLTGDLQHLSPKLRSKRTKVEVLRSALQGLCDMHKENIVHNDIKADNVLIEYEEAEAGEEMVKIKSVQISDLEDTVLLPAGMWFSEGICGNAIWRSPESWCRARQNISSDIFSFGIVMIYVMTGKMVFHIGWDKLDAEDAWRHVLSRHISYFADEEGLNGLLKHIQKENPFFERLVSLAENVPRQPFEAWGSVEPQLKNLVGKMTCLDPSRRITAAEALEHPWFKSAWMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2N5</accession>
    <name>D4D2N5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024510.1">
        <property type="nucleotide sequence ID" value="XM_003024464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2N5"/>
    <dbReference type="GeneID" id="9579733"/>
    <dbReference type="KEGG" id="tve:TRV_01341"/>
    <dbReference type="HOGENOM" id="CLU_035429_0_1_1"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="484" mass="53122" checksum="318BE6C01A4E28FF" modified="2010-05-18" version="1">MKELQVDLFRCEPKAEQSKAKQKAQLNDPPNLALVSSSPRIRVLVLHEPGSFHSLPPLLPALALRLVLNGIMITSSVRRAALPSTASLPSRAVLLAVSSSSPAPGPTSGNPPYRHQRRYSSSKPPVPPSDGSRGIDPPTQTPAKSVSSGPSSKKDVENREGRSSKKRAGKDGETAKSKQASSLKLPSVPSTQHLHPHACSVTDHDIVLDVHVASFFSIHRPMSITTSVPPNNNDSKTFSAIFSPKKQAAARQKDVIYTLSSAVNAIEQNLPGQNQASAEDIDFRNAISQASSIHAESDVTHLDGVPTQELRASIQEFAKRLRPFNPPPAPTPMDGPLESIAGTESGADKASSTQSASEAEPSEQTFSTVLTIRESRNAHGRKSYEAYASPFVRIDDMEAPSAQGESSIYQDQETSDRSVSEPKQSFLQRMVIRQLQWERSQGQRQRERMYTISVKRQRKLKMKKHKHKKLLKKTRTLRRKLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D376</accession>
    <name>D4D376_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024335.1">
        <property type="nucleotide sequence ID" value="XM_003024289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D376"/>
    <dbReference type="GeneID" id="9579462"/>
    <dbReference type="KEGG" id="tve:TRV_01535"/>
    <dbReference type="HOGENOM" id="CLU_900768_0_0_1"/>
    <dbReference type="OrthoDB" id="4173787at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34132" checksum="9F398AB8D1AD42DC" modified="2010-05-18" version="1">MTSLYFQEPSSRVWDYLEQMETDWIHESSIASDSNANSGELTWGAQFSHFPKQKPTATRARSLRREPSDASSGYRREFLSRRDRSVSGSSFSSMSTNSRLSSSLASHDRPADLGSVIQNLSSQLGFDLNETFNCANKYSKPVKSSKTRPSAPVAAPLKAKSTKAPNVRHEFVLQVPYAQKPATTVEYDSMMSALNIPVKAATAPATPKADHKNAETKDSGVKKTKSTRKVSFAEVVQELPIALETEAEPEPEPEMITDGGSDSDSDSDSVPEAVFLNVDTVMQNAPRVRHVEIRDAEEEENDYITIYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D381</accession>
    <name>D4D381_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000081">
        <property type="protein sequence ID" value="EFE43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024291.1">
        <property type="nucleotide sequence ID" value="XM_003024245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D381"/>
    <dbReference type="GeneID" id="9579411"/>
    <dbReference type="KEGG" id="tve:TRV_01540"/>
    <dbReference type="HOGENOM" id="CLU_056019_0_0_1"/>
    <dbReference type="OrthoDB" id="5339271at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="33701" checksum="918A7DA99F7D478D" modified="2010-05-18" version="1">MTIDYTSKGDIPHTSYYDSVYMAKALDSALDMEFEGFDDGKLYWDMFLKLDRTQQSPTDPTIVLDVGAGSGRIFRKMALKAAKSGEDLSDVRFIGLDKSSSMVERAKSRASELSDVGSVTWIVGDASDMLAQPDLSQLRGQLSFVLCADGGIGYIEGEANIHAFFYHIAKLLRPGSGRACISLLEFQVAGAYKDGVVPSTYDESTESMDEYSKGSSLSFKPIFHREYVEDGHHVGRLDTEISKVDKEGNKTILEICHYTHRFRIWSIEDMIQTAEKAGLKHVETIDWQRMQHFVFMVPEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I3</accession>
    <name>D4D3I3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024210.1">
        <property type="nucleotide sequence ID" value="XM_003024164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I3"/>
    <dbReference type="GeneID" id="9579248"/>
    <dbReference type="KEGG" id="tve:TRV_01643"/>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="208"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="615" mass="67560" checksum="357547D1A4237C89" modified="2010-05-18" version="1">MVRQTAFLLPESFPASAETSRTPSLLVITARQLPPSPVLRSSPQTSLLAMDLEGSDSPWGAKETQPAAEQSSTSLSVPQSPPTARGPRAPRKVSAQVVKLEPAGDVLDPLGPLGETSSFSAADAQTQDQRPAPPRKESFTSRSARPTSSASQTSSAAGVTTLMESVDLDEDGPSARAKGPPPVQPAPASSTADKRQNQSISVEQAAKPSFYITVGDPHKVGDITSSHIVYQVRTKTTSKAYIRPEFTVTRRYRDFLWLYNSLHSNNPGIVVPPPPEKQAVGRFDTNFVESRRAALERMLNKIAAHPTLQHDGDLKIFLESESFTMDVKNKENREPDLGQSKGMFSSLGISVGGGGKFIEHDDWFHDRKIYLDALETQLRALLKAIDTVVAQRKNLAEAASDFSTSLHSLASVELSPALSGPLDGLAEVQLRIRELYERQAQQDVLTLGITMDEYIRLIGSVKTAFTQRQKSYHSWHAAESDLQKKKNTRDKLLRQGKSQQDRLNQAHAEVADAEKRVHQSRLLFEDLGRVMRNELERFEREKVEDFKSGVETFLESAVEAQKELIELWETFLLQLDADEDPAAAHSSVAAPPSEGNGPSHQPSESNSTSRDQDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R4</accession>
    <name>D4D3R4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphatase (Ynd1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024126.1">
        <property type="nucleotide sequence ID" value="XM_003024080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R4"/>
    <dbReference type="GeneID" id="9577123"/>
    <dbReference type="KEGG" id="tve:TRV_01726"/>
    <dbReference type="HOGENOM" id="CLU_010246_3_0_1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="167"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77013" checksum="D8ADFE9A319AE89E" modified="2010-05-18" version="1">MQLFWTLDRPWPKKAHKDAGSKDLAKLPPIETTKEWTKKIKPGVSSFAKNPENVGPDHLHKLLKHVHSVIPRKEVEDTPIFLLATAGMRLLSDNEQKEILKNVCSYISDNSGFLLPDCDAHIKVIDGKTEGLYGWIATNYLLGGFDEPKAHDHGKGHHTYGFLDMGGASAQLAFAPNSTEAKKHANDLTLLRLRTLNGQSNEYGVFVTSWLGFGVRQARSRYVKALLKGAPAGTVNRKFPDPCLPDGLRTTLEGTILPSDGPVPGTDSYLVGNGKFEECLRETIPLLAKDTPCEDEPCLLNGVHVPAIDFDVNHFVGISEYWHTTHEIFEMGHQDKAYDFKTYQMRVNEFCSTPWSAIKDGIEQKKWGKVDQETAYEVCFKAAWIINILHEGIGIPRIGLEASTNNTNSATKELGGHGKNGQDKTYLDPFQAVDKINATEVSWTLGKAVLFASSQVPASKASLPVGFGSNTPGKVPDDFEYPSSNQPHIPTPPSNSDKNGTSENWHDTLFDGDSPRRIPGFFIFAIIVLIVIFFLLGRERRSRIYHKLGMRFGRGGNNGGNSRRRSPFFRGKIPFLSRRGPGISYERVLEEGDHRDFELGSMDSDEDSQGSSSSSPPSGAAGSRPLARTPHSQSPKYNLDNSSLLSIASLNNSLDRRGLVIRTESRDRLYAPALAPTTVGRKSRATSPIRLSTPITNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3X5</accession>
    <name>D4D3X5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024021.1">
        <property type="nucleotide sequence ID" value="XM_003023975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3X5"/>
    <dbReference type="GeneID" id="9582714"/>
    <dbReference type="KEGG" id="tve:TRV_01788"/>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34243" checksum="E47778B79A48D981" modified="2010-05-18" version="1">MNLNDLRRLEIDIDIFLNRFIPHPRWHRYPYPVAHFLGHRREAVPKLGTLVVIFWTFVGVFCGLLTITGISQHIPSFKQHDAPLVVGSFGAAAVLAYCAIESPLAQPRNAILGHLLAAVVGVGITKLFGLHPRHEELYWIAGPLCCAAATLVMALTKTVHPPAGATALLSAVDPRTRHLGWFLLPVVLLACMLILVTALIFNNIERRFPTHWWTPVSLIPPKAADLESSTSEETVHPDQSDESPPDEGNDKQPVDQIIISPGQVDISGSITLTAAEYDFLERLSRRIIDIDEKDALTDEKEKADETRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D458</accession>
    <name>D4D458_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000099">
        <property type="protein sequence ID" value="EFE43362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023980.1">
        <property type="nucleotide sequence ID" value="XM_003023934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D458"/>
    <dbReference type="GeneID" id="9582673"/>
    <dbReference type="KEGG" id="tve:TRV_01872"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_2_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31414" checksum="63C370DC219A3EFF" modified="2010-05-18" version="1">MPDQSLYFYKASLPAAAVFAVLNAIPAAFLFYTTIIGPKTGKYRNASFFIPLCIGGLMEVLAYIVRCISIKMDRVIALYAVSSSLIVVAPVLVCASLYLLVGRLVRAGLPSSGNQQRILGINPWWLPRIFVTSDILSFLTQASGSGIAASGNWEGSTKTTGENVLKGGLALQLITFTLFLALVARFHSRANAVAKGGVDSGVFKVLLGLYISGFFIEVRCVYRLIEFILGIDGYPFRHEWPLYVLEGLPMLFAMFALAYFHPGKWLPNESLNSETDNEEMQNRNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4F3</accession>
    <name>D4D4F3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023918.1">
        <property type="nucleotide sequence ID" value="XM_003023872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4F3"/>
    <dbReference type="GeneID" id="9582530"/>
    <dbReference type="KEGG" id="tve:TRV_01969"/>
    <dbReference type="HOGENOM" id="CLU_2559951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="82" mass="9813" checksum="9B3372C45C13966F" modified="2010-05-18" version="1">MRKKKEKKKKKKKTRKIIITRRKEKKKKRKEEEEEKMTMTTKAELSPRLLFFSFLLLLLFLTSSYFIVSFSSLPSTALLSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D518</accession>
    <name>D4D518_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023679.1">
        <property type="nucleotide sequence ID" value="XM_003023633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D518"/>
    <dbReference type="GeneID" id="9582226"/>
    <dbReference type="KEGG" id="tve:TRV_02187"/>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="355"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="734" mass="80337" checksum="EFF211BC722A95AA" modified="2010-05-18" version="1">MGRKRKHDDVASDDAQPDGSDVTAATSHGGNGFGLADTLSLLRDGDGPREPALPKDTSGGEGKDQTGGWQMVDHTSKKRKRIGNEKTKYPTLTYAMGGRQSSIKISDLQGLLLYCLADAVAPQWISVKHSGHVRKVVMLMVPGLELGMFDGSIPLSKGAETPTPEVPDAAADNSQSGEDAKKSSEFERWKRGVSPISEETSRQFAPRAIHKDKLPEALSPLADMFPHVWPVKSPGDSKYNKVHSPLQAILRSSLPKSKENNNNNNKKSKGPGNWVSQRTPITTFLSTLDDLIEHEYPLHPALFSSAEERDKNARLRAMNGQSTEHGWVDTHVDDFAQGAVPDCDIAEGSVTAGRDIFALDCEMCITEGGKSELTRISLVSWDGERVLDEFVKPENPIIDYLTRFSGVTKEKLDPVTTNLSDVQQKLLGILTPRSILIGHSLNSDLNALKLTHPFIVDTASIYPHPRGPPLKPSLKWLCQRYLGREIQKGMAGHDPVEDAKAVLDLVKQKCEKGEAWGTNEASTESIFQRLARSSRPVKSSGPVSQGGRTGAVVDWGSPERGFGAQASVTLGCANDEEVVRSTKIAVSGDPTGKIVSGDGVDFTWARLRNLEISRGWCNRIPGASQNNKSINISDQDIISPANPDELGRAVAKTVSCIKEIWDHLPPCTLFIIYSGTGDPREVTRLQAMRRTYNEEFRNRKPWDELTVKWTDTEEQALKRACQAARDGCGLMTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D581</accession>
    <name>D4D581_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023619.1">
        <property type="nucleotide sequence ID" value="XM_003023573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D581"/>
    <dbReference type="SMR" id="D4D581"/>
    <dbReference type="GeneID" id="9582165"/>
    <dbReference type="KEGG" id="tve:TRV_02251"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056204" evidence="9">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="499" mass="56092" checksum="64D7D61C150E87FE" modified="2010-05-18" version="1">MLSLIVACLVLPLICYKLVRSYNQSREDEQFAASKGCQPPRKWSAKWPLGLDMLVKAVRYEKRQQILQLFLEEVAASGSTFEQNLLFARGIDTVEPRNIEAILSTQFTGSGIFTQDGPQWKHSRELLRPQFMTNRFRNFEQIRHAVNNLISSVPDSGVVDLQPLFFRLTFETTLFLLFGHYLPSLKSEGITGHESQFANAFNLGQDYLAQRGRLGDLYWLLGGREFKDACKVCHDFIDNAVQKALKHSSREKKVSDEEKETYVFIDALVQETREPSVLRDQCLNILLAGRDTTACCLTWTLRLLVQHPDVLSKLRDEVRDTIGMGPDAPDPTISQVKKLSYLSLVIKEVLRLYPSVPVNSRAAVKTTTLPTGGGPDGSAPLLVRRGEAVGYCVYAMHRRKDIYGPDADCFRPERWENDALKDVGYGYLPFNGGPRICLGQEFALLEVGYTVVRLLQTFETIEEAETKVPGAPLGEEKQTLTLVVSSGEGCWVSMKKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5A3</accession>
    <name>D4D5A3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023526.1">
        <property type="nucleotide sequence ID" value="XM_003023480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5A3"/>
    <dbReference type="GeneID" id="9576998"/>
    <dbReference type="KEGG" id="tve:TRV_02273"/>
    <dbReference type="HOGENOM" id="CLU_688821_0_0_1"/>
    <dbReference type="OrthoDB" id="4171017at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="40572" checksum="7B9C332297C2CAF3" modified="2010-05-18" version="1">MDPASEHSWSLFQYIRELLAAPEKHTHDWSEAERHNFQHSPLYRLPAELLGIIHEYLPPNNSFALSLTCARFYFSTILAGAQRELKSTKMGQFIVMCMLEGVGQIKEYCCRGCLTTHPSSHFSKDELEKRHAERYCLRTKKVMAFGAFGSDPKSFNEVLEMRRTRELEENIDILQQGSFWNLFSSPKISVVTGIRLFPQGKKVSVERFAELCQKLNYPVCPHMTTADKRIVDLYVPDFFRAGKSNIPYPFSQHFERNELGVKCKVYEAANSFYYATQAPIAGTAIESNIDCIPLSLPKSSLMTRLGVTIWSAVSSCIPEKHHRRKSGHLHRVVISDHLYMLTPQFQREREGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5F4</accession>
    <name>D4D5F4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023577.1">
        <property type="nucleotide sequence ID" value="XM_003023531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5F4"/>
    <dbReference type="GeneID" id="9577049"/>
    <dbReference type="KEGG" id="tve:TRV_02324"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="111"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="338" mass="36467" checksum="D71AB3FEBB3FB95A" modified="2010-05-18" version="1">MATQLTALNLAAVKEAYTLIKPKIWKTPVYKSATLSHTISSTIFNKYKIGITGIPKINVFFKCENLQKTGSFKFRGASHFLARQNDQELRNGLVTYSTGRYYPHALSSQLGKISMIEKLGATVSAGYPTMEACAVQAEDLQRKAGLTLVPTSGHCHVVLGQGTVMLEFQQQVAALGEKPLDAVIVPIAGGALLAGTALVCQEASSRTDVFGAEPLEGGPSLFQGRQRGRLINTLCPDKSTIADGLRCLVAKSNWDILRSKTHVQDVFPVADSEIRTAMRLVLEGTKQLVEPSAAVPLAALLFNKRLHSNLARRHGPLNVGIILSGGNTSVERLLSLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5I9</accession>
    <name>D4D5I9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023509.1">
        <property type="nucleotide sequence ID" value="XM_003023463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5I9"/>
    <dbReference type="GeneID" id="9583529"/>
    <dbReference type="KEGG" id="tve:TRV_02360"/>
    <dbReference type="HOGENOM" id="CLU_344237_0_0_1"/>
    <dbReference type="OrthoDB" id="4174424at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055598" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="67507" checksum="F8C82F3F8E343EC1" modified="2010-05-18" version="1">MKASIGALALLLAQQASAAYIPTGSTKGSALVRRQWDGFNGGDQTVDPGYNQPPPCPECEAQCPGGNCGGGYEPEPQCPGGNCGGGGVPQCPDGNCGGNGDGGIIGGGGIIGGGGIIGGGGGGDCWGGNGGQPPACFPVPGNQPPDCTPEQHGGFDFIDLIEGAIEFFGGCDFSGWTCVDGIVKGALEVTGKVITAVLGAGGDNIPTISKPSGGLTITSLVVHAEVKVEIVLEFTMKDGSICRQFATCSPAGETIINEQCAGAVSVGFRLSVTSHVSVCAVAITKINFGCEPPTIPTWPSPPLPSPTTSLPPPETSGGYTTIPGTSESGGTSLPYTTPSGGFPTSSGAARQKFPTAQLAPLQLLRFLSPQLSALSRPPQFLDSPVNQASQASQVNQASQVSQNSQVSQVSQVSPVSQASQVSQVNPDSQASQVNPDSQASQVNPDSQASQASQVNPDSQASQVNPDSQVLPLLIHQSFPDEFAQKVIDCIRSWSKDEAETQVALSFFIGICVTYVPQNPGLVDHLPPGMPIAPTPAPSGPAPPAVTLTITPTMTGNHTVPPSTIVVPSITFATPTPGAPSQAPYPVPAVPTSEGGSVPTPAPGGSPGGAPAPAPPYGSTGFMTVSPTGGVPHPTSTTEPYIGAASSAEAFLSQWVMMGITAMVGLIQFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5N0</accession>
    <name>D4D5N0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000124">
        <property type="protein sequence ID" value="EFE42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023466.1">
        <property type="nucleotide sequence ID" value="XM_003023420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5N0"/>
    <dbReference type="GeneID" id="9583486"/>
    <dbReference type="KEGG" id="tve:TRV_02403"/>
    <dbReference type="HOGENOM" id="CLU_001482_3_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="443" mass="49381" checksum="187C00381621339F" modified="2010-05-18" version="1">MTDWVAYMDDNTKAKRISWIQGLNMGGISDWALDLGGWFSGIKENGTIGWTVEPDNLDCDRNAWPKTLEDLDANIGKVPIHCRGMALMDILTKELAGAVDKYREVSSSDDYKQRFEWYADWVKDSIEPRLMKFTALKTGEGLKYMDCKWSTPYAKGQGPCTEVNLYDPDHADPGGRTVEYTLRDEEGFYNALMKDAGISKEWIEWTTITEPDYCPTCPPKNEFCPPKPCADNYIKYVNVPSRIPDKNKIKVEDPKDLIEKAIPHIDDMVDLAYITSYELSMGILDADITDVITSLSMPVFMLQDASKSIEEIKKIGKEHHDTKKKELILNILSIVFSIIPFVGFAGQAVGIATRFATAALIIGEIGNAALSIVDIVENPAAAPFAILGLLIGAEGVQVRGAREAFKKAANVRRALKPDGLKSFSQEFVRKDSLVQGLLKKCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5V2</accession>
    <name>D4D5V2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023373.1">
        <property type="nucleotide sequence ID" value="XM_003023327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5V2"/>
    <dbReference type="GeneID" id="9583393"/>
    <dbReference type="KEGG" id="tve:TRV_02475"/>
    <dbReference type="HOGENOM" id="CLU_090064_1_0_1"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23861" checksum="2A7533316FC7C17E" modified="2010-05-18" version="1">MSQPSELAKKRAEDYKRFKLYAAVGIGVAAPILIALPPRKLDVYTAALVTACVASVDYLLTERTGKGILSQMATLVPAKPTLLNDLPTKKAEELNERMRIARIQEQELERLRGSMLGEEEEEEEKPSLRKSIRKFWMGRETEGWIERRREEERKALAEGKSYSEIMMDYFRDAWRLDEGREQGGNTEKNPVEQQEVQPVEQNEKDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Y6</accession>
    <name>D4D5Y6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023407.1">
        <property type="nucleotide sequence ID" value="XM_003023361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Y6"/>
    <dbReference type="GeneID" id="9583427"/>
    <dbReference type="KEGG" id="tve:TRV_02509"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="57602" checksum="921B98CE341BA242" modified="2010-05-18" version="1">MNNQFLPSCLPSSLLPELTTEPGIGDYSVLTMAEHTPASHSMDPEKDANIPELALNNSNLPESSRVPEPDLEKGEVPGSVPSPPLSYDEPKKNPDLVNWDGPHDPENPRNFGRMRKWYIPMMLSLLTFCITFSSSVFSQATAVTAKIYGVSVEVTTLGTALIVLIPVAVAQNLATILICRFLIGAFGSVTLAVVGGALVDLWEPVDRGIAAAGFCAATFLGPIAGPIIGGFIVPSHLGWRWTNWITLILDAAVGLVALFSLPETFAPVILQNRAKRLRYETKNWALHSTLDESPLTINDIFHKYLSRPFEMLILEPILSLTTIYLSVVYGILYLFFFAYPISFGEVRGWEHPGVAALPFIGLLIGILLGCGVLIYISKHQYAQKLKETGNLVPEDRLPTMIFAAFTLPAGLFWFAWTSSPHITWVPQVIAGVPIGFGLIIIFLQGINYVVDVYLIYANSALAANTFIRSLLGAAFPMFASQMYHNLGVAWASSVLAFITLAMIPVPILFYVYGARIRAMSRFVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6C9</accession>
    <name>D4D6C9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023191.1">
        <property type="nucleotide sequence ID" value="XM_003023145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6C9"/>
    <dbReference type="GeneID" id="9583211"/>
    <dbReference type="KEGG" id="tve:TRV_02654"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="135"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="620" mass="69188" checksum="27580ABD2E0615D0" modified="2010-05-18" version="1">MTKSTRPLAIPSHIEGTRTDDILSESMLTPGSSSTGWANEDVTSTSLSGRGVGLKRLETEIPNEDDRPGISPSREDEADDEQDGDDNELDRSGNERYRDNPGREVEDDLEMASYSLNSYTIEEERQVVRKFDRRLTMFLAFLYLLSFLDRSNIGNARIAGLMDDLNLSSGQYEWALTAFYITYICFEWMTLMYKILPAHIYIPICVFSWGVLASMQCLVTSFWQLVFLRALIGVSEAAFSPGVPFFLAFFYKREELAFRTGMILCAAPLATSFAGSLAWFIVWVSENGPIAPWRALFLYEGFPSIIVAFIAWSYIPDGPGKAKYLTPRERKVAKLRLKAGKRKHEIKKTRFDWGEVGRTLCDPKSYLTAFMFLSCNVAFSSLPVFLPTILHDMGYSKLTSQALSAPPYLFAFVVVLITASLSDRHQSRSFYLIILALISSATYLTIALTGYFHSHLPTSVHILIRYVCLYPAAAGFFSAITIIIAWTMDNKPAGEGKGTGMAILNVVGQCGPLIGTRLYPDTDGPWYIKGMMVCSLFMLLVAILAFSLRILLQRENRRASADAAGIASAVRRETALDCEEDAMLRTEERDGATEMLMGPGVSKSPAGIEKTSRPRFVYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6D7</accession>
    <name>D4D6D7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023199.1">
        <property type="nucleotide sequence ID" value="XM_003023153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6D7"/>
    <dbReference type="GeneID" id="9583219"/>
    <dbReference type="KEGG" id="tve:TRV_02662"/>
    <dbReference type="HOGENOM" id="CLU_148212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="147" mass="17250" checksum="E41FBC0D8019921E" modified="2010-05-18" version="1">MFNETREEKAGRGELRRKKEEREKKRDREINNSRWEDKKCGRQNTLLLKKEKKPRREETSIYDMGRKRMQPTDQPASQQRQQQHPSTATDTPSIHPTDRPTVHPGGEGDEFNNEEPTKGNNTTTQPAFYHQVNDNQTNDEYPVSSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6J8</accession>
    <name>D4D6J8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023145.1">
        <property type="nucleotide sequence ID" value="XM_003023099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6J8"/>
    <dbReference type="GeneID" id="9583153"/>
    <dbReference type="KEGG" id="tve:TRV_02724"/>
    <dbReference type="HOGENOM" id="CLU_452120_0_0_1"/>
    <dbReference type="OrthoDB" id="4170788at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="604" mass="69691" checksum="2FD2C522C379DAC8" modified="2010-05-18" version="1">MSTANFDWGLVGIMAEVDDVVLHQPNQPWPNSAFVLGGGMFASDANLFAVFNTREHIIEELTRLLQQIQSLRVQSRLLLEQPVPVGFLDVVAAQLMPQWTARDMPSPIRQLVETVSYQAASIGILNLPFPTREAIYRLVLDTKYTMKQSIHPDWVTAEVIDDTASSDIQTAWIWSRCPRVTKYNIHPAILRVSRQIYHETVMVLGRQNLWVVVSTSDTRIAQGLTEMGAALPIPPNWRGLGLPGYSPYVYHVPIEMHVEENPNVALAEQQFFVMALDCVWDLVALMISYSSTPWSLTVRLNETTFFSHQQKLDCIARIVYMLEPLRLLGEDDYSRTVTFWFQNRIAGDRMIRLNRLQNRFSAIELIGMLREYLDPFNANLWQINWAKEDLKMAEWGFFFIHAMNKYGANEQYGRMWRDTLCIGHARLMIIRLAQGKLILAKHHAQRADEVAELHQVTLWWCKPLISRITGWDDEIPNRDTIDEALRAIWCLCWNERKSWFHLLWQHYKGAEHEAHGTIVYAVHLLEGIRLILANTNEANDLKKQAKVFNNLMCIQGTGLNDGCTPEQRDYHNLTTRSVINDSRLPDSVQQQSIEEGVMLWRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6K9</accession>
    <name>D4D6K9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023156.1">
        <property type="nucleotide sequence ID" value="XM_003023110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6K9"/>
    <dbReference type="GeneID" id="9583164"/>
    <dbReference type="KEGG" id="tve:TRV_02735"/>
    <dbReference type="HOGENOM" id="CLU_077442_0_0_1"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF3">
        <property type="entry name" value="FUCOSE-SPECIFIC LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="31759" checksum="420FE34EB1DD4933" modified="2010-05-18" version="1">MPPNPSTFTALNVPSGYTLPESLEYFSLAARPDTDLWRKPPDRETSTAPILYTSLQRPFVLAEVTVTADWEMEWDQGGLVIFSGPPPGPRLIQPNNSNELVPTTVINLDNNNNSVNAGEQQQQPPQPPPYPDFNLGQGKWVKAGLEFSAGTVNASSVSATSDGADWCLSPLAPPNQPTSITSLRIKLERIGHSLWVWYQIPPSSFSTDQESSHSPGSAAQSWRKLREVTWFFWGVEDKSVHIGVYACRPANISISSTMWAARNGGQYFHDNSPSPNSLVVDFEDLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6S6</accession>
    <name>D4D6S6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023056.1">
        <property type="nucleotide sequence ID" value="XM_003023010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6S6"/>
    <dbReference type="GeneID" id="9583076"/>
    <dbReference type="KEGG" id="tve:TRV_02803"/>
    <dbReference type="HOGENOM" id="CLU_031740_3_1_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11020">
        <property type="entry name" value="CuRO_1_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04208">
        <property type="entry name" value="CuRO_2_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000093">
        <property type="entry name" value="Copper-containing nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0186">Copper</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="147"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="436" mass="47375" checksum="7EF6C9257ECBDE6F" modified="2010-05-18" version="1">MKQLCLPFRVPLGRITLRAKLSTLPTAGCYSVIPKKPVSLPLQRVSTYTSKSSRVSEANHTPLAILVGIATTIAVGSVVVSRNRKEKSREIFTIKSNTGVDLFAETSADYSKLPKETAVFTAAPHVPPPITRDYPVLLQVPLTTSTKTTQLSNQYKYEQWTFNGTVPGPFIRARVGDVVELTLTNHDVTGNPHNIDCHAFTGPGGGAALTTAEEKESKTGLFKLLHPGLYVYHYAAAPVPVHIANGMYGLIYVQPEDGDLPPVDREYYVMQSEFYHEPPEVLENGRRSSTVEFSYPNALEENPSLVVFNGSESALTRDQPLKAKSGETVRIFFGNAGPNLTSAFHVIGTTFSKLYRDGDVVSPPANWVPTTSVPPGGSTIVDLKLVVPGTYTLVDHAIFRLDKGAVGYLNVSGKQRPDVYQSTLPPAPCVGCKLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7A1</accession>
    <name>D4D7A1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022900.1">
        <property type="nucleotide sequence ID" value="XM_003022854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7A1"/>
    <dbReference type="GeneID" id="9576938"/>
    <dbReference type="KEGG" id="tve:TRV_02982"/>
    <dbReference type="HOGENOM" id="CLU_2063183_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13295" checksum="43F145E262EE859E" modified="2010-05-18" version="1">MPKARSAGAASRGHGGSSQGAQQGRRAADVFLLLLALRIANGLLVRTFFQPDEFFQSLEPAWGIAFGRDSGAWITWVCIPPPRKGRNREKRERGEKNRDRMEKKGRCGRCGWLTIWGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7H7</accession>
    <name>D4D7H7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022835.1">
        <property type="nucleotide sequence ID" value="XM_003022789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7H7"/>
    <dbReference type="GeneID" id="9581559"/>
    <dbReference type="KEGG" id="tve:TRV_03059"/>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="147"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="487"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="976" mass="105052" checksum="7846D00614A2945F" modified="2010-05-18" version="1">MATKGGDTAITASNEPLAQLKSATVPPSPNSQSLVDQVSLFVAHADRTTLISISAGVVAVSYVLFGRLALLLVGAIGGVILHIWWEGQDNGTNGDNEGAAKRKRHELSLEVANRLTALYADNGSKQDDDEDTLNRSGESSLDYSRMGPATEAALTALTDSVIADYVSWWYKPILPSEDEFPEACRNTLVSMILAVSSRISRKRPADMFLQFATNSTSFMIVFFSELSAAVGTATTGSRPVADSIDEYLDRNPESSLANVLSSTQQEKKLGLVGTDILKTFLEPSVYNCGPLRIFLREVLSRLILQPTIDMCSDAEYINTWIVYLLEEGEPQLLNAIDAGLEQADNVKQKNPTSTGTPTSNVLEGKVSNIVTNLGDQKLAEQVQPMRQPFDADFAQHEDISAVAMPKEIPRAADSEETSGNSAVYTHLPTDSSSSNTTDHQPTPGSSTSLNEDSLDNPPLASQTTPILNTSATSLITMQTSQFRGSSVAIIEDFNEDDKSNIRSKPTSEYLIQIEPSNPKLTGWMIARKYSDFEILHETLRRISVVSGISDFSLHHNELPGWKGRNRNGLRISLEKYLQTALQYEQLAECEGMKKFLEKGRQSGLEPESASSKSGFPFAAPVAVFENVGKGVMGVLGTAPKGVANSKKAIVGGVSGIFGASGNDNRKRASSNAASRPTAVRGTSMDILPSPVTNVTAHSKNLSMSNLQDRPRATFQRQPTHLENESGDIGSGLPTSITHADSSLASSCENLADEGNVTPLSSSDTPDTVHGALSSEANVESNKEPATRDKPGSSSSGDVEPPPKKSSEGRSYAPVSEEEAVVVVELLFAVINEVYSLSSAWNIRKRLLNASKSFLLRPGNPSLEAIRTLLQDSIIDSNTSDEALAGYITKLHKSSLPTEEDMKAYPPPLSPEQKELLRIKARTLLISRGMPPALMGIMGANATGEALGKIFDCLQIPSVGRAFVFAILLQAIRVMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7K0</accession>
    <name>D4D7K0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022786.1">
        <property type="nucleotide sequence ID" value="XM_003022740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7K0"/>
    <dbReference type="GeneID" id="9581521"/>
    <dbReference type="KEGG" id="tve:TRV_03082"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="524" mass="57058" checksum="36AE6CB0FA46A154" modified="2010-05-18" version="1">MASEDSEKSPVEQKTGLDKEIPVSSGASRDLDQAYRFLQQYGESGESAQASAAELKRIRWKVDLYIIPIMFVCYTMQFIDKVSLNYAAVMGLNKDLKLKGNNFSNAATAFFIAYLIAEVPTGYILNKISAPKWLALNVTLWGISTACTAAARDYKTLLAARIFLGIFEAAIAPCLVLISSQWYTKSEQAPRFCIWYSGLGLGQIIGGLVSFGFQHVKNPDFTGWKAMFVLLGAVTCVAGIATYLIIPDSPMKARFLTEKEKAALLKHVSCNQTGVINTSFKMAHIIETLLDIQIWFMTIITTLISVSSGVVTTYSATLIKSFGYSAPRSALLNMPSGAVSIISTVVIGFAIRYKMYRSVGIVACCIPGIIGGALLSFAPEHNQGALLAGIYLVNSIVPTLIVIYQWLASNVAGSTKRSVSAALVTASFSIGNIIGPQTFQAKDAPRYIPAKIAVLATQACGAVLAICLLGYYIWENKRRDRVAAQNSQALPVSEDTTLSQTTSAEQKKWDNLTDKENLTFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7U0</accession>
    <name>D4D7U0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_03174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022713.1">
        <property type="nucleotide sequence ID" value="XM_003022667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7U0"/>
    <dbReference type="GeneID" id="9581402"/>
    <dbReference type="KEGG" id="tve:TRV_03174"/>
    <dbReference type="HOGENOM" id="CLU_000288_120_1_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="249"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="507"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="613" mass="68330" checksum="EC4D3D133FE9F5B8" modified="2010-05-18" version="1">MSWNITKKLKETHLSALSNLSSSLASSKDKDAPTTPTVSSASSTKEGGPAPDTNTSKPGILVVTLYEGRGFSLPEQYREAFASHHRTNSSTGGVAGSTQQSSLAVGRGNGSTRPQTSGGGFTGIPTNHGRISRKYMPYALLDFDKLQVFINSIDGSPENPVWAGSSTQYKFDVSRIAQLTVHMYLRNPNAAPGSGRSQDIFLGVAQISPQFDGPYREVEWIDLQYGTGKLQIGWEYVETQTNKLNVDDFELLKVVGKGSFGKVMQVRKKDTHRIYAMKIIRKAKIISRQEVTHTLAERSVLAQINNPFIVPLKFTFQSPEKLYFILAFVNGGELFYHLTKEQRFDINRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYQGHIALCDFGLCKLEMKDEDETHTFCGTPEYLAPELLTGHGYNKTVDWWTLGVLLYEMLTGLPPFYAEDTNEMYRKILSDPLTFPSHDIVPATAKDLLTKLLNREPSERLGANGSAEIKAHPFFHAIDWRKLLQRKYEPAFKPNVVSSTLTPGLPYIIISNYFSKADALDTANFDVQFTSEPAQDSFVDDPVLSQTMQNQFAGFSYNRPVAGLNDAGGSIKDPSFIDNVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D814</accession>
    <name>D4D814_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022592.1">
        <property type="nucleotide sequence ID" value="XM_003022546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D814"/>
    <dbReference type="GeneID" id="9581247"/>
    <dbReference type="KEGG" id="tve:TRV_03249"/>
    <dbReference type="HOGENOM" id="CLU_042177_1_0_1"/>
    <dbReference type="OrthoDB" id="5391950at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="253" mass="28407" checksum="09D093392BDEFC34" modified="2010-05-18" version="1">MEQRVLSVHKKSLKRKHDESDLSEESVSPLSSPDQPDEEGKPEIIDQADVKPPGAYLHGNVANKFRDLDIRCRTTNNEELRHHPPPEYDIQPQSSEIPPELPTHGKISKTRENGDDSKLLYSTARSTSFTNEATPEKKDPACLESPPPTSNGNTDAEATEESLTWDESEITGHHATDPNDDGYGLNGIGFKPSAEVAWARSQHRKDQVAEWKRRMASEAREARSRRRQKDEDICNASYIAKGSPKQKRVKFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8E3</accession>
    <name>D4D8E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000175">
        <property type="protein sequence ID" value="EFE41886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022504.1">
        <property type="nucleotide sequence ID" value="XM_003022458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8E3"/>
    <dbReference type="GeneID" id="9581078"/>
    <dbReference type="KEGG" id="tve:TRV_03379"/>
    <dbReference type="HOGENOM" id="CLU_087180_0_0_1"/>
    <dbReference type="OrthoDB" id="4174337at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="28942" checksum="5A9768F9F5645485" modified="2010-05-18" version="1" fragment="single">QVRPARYDVSFSSLNPISSHLFPSLQVFIDSPSAINMIVSTKLILAVLAFDAAIAAAGMWRRDIVALQSQHLSTIAFTSFFRDLLKTQLLTCLSCIARAYGPANVHHGNIFGRDGKYMLTPMFAKENKQRNASKMAMLTGIIGEAAVTVTVTDCNSASGPAPSGPATSAPAPSAPATTIVSVSVPDVTSAVPTGRPEAPITSSVEHTTTGASTEVPPPSMSTPVSETKTSVVSHETPRPTRASPSETVATPTPSAMASRHVGFNAVLAGVIGAAIFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8R3</accession>
    <name>D4D8R3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000181">
        <property type="protein sequence ID" value="EFE41756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022374.1">
        <property type="nucleotide sequence ID" value="XM_003022328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8R3"/>
    <dbReference type="GeneID" id="9580920"/>
    <dbReference type="KEGG" id="tve:TRV_03501"/>
    <dbReference type="HOGENOM" id="CLU_2322045_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="99" mass="11405" checksum="A7E5BAD0CFBD465F" modified="2010-05-18" version="1">MTGRLLAYLLDTKRLIPGKPMQLMFPMRDTSVDYLDPSYKIYQTRCSARAWIQLRFHSHCRVDFSRGTKAELVVCLVHTPVAGTIIDLRFSALLKIIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Y1</accession>
    <name>D4D8Y1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022358.1">
        <property type="nucleotide sequence ID" value="XM_003022312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Y1"/>
    <dbReference type="GeneID" id="9580905"/>
    <dbReference type="KEGG" id="tve:TRV_03569"/>
    <dbReference type="HOGENOM" id="CLU_032651_0_0_1"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="293" mass="32038" checksum="66308A14FFCADE0B" modified="2010-05-18" version="1">MAAQLPQLDSLRSQYRKSLQSFNAGLDDFRLLDIVPPEGEQNAQPGSLYVLDSSFNPPTIAHTQMVTAAVKAANAKGPPPSRLLLLLAIQNADKQPKPALFEDRLVMMRLAAEDVLQALAQDTSRGKDGRICNLAIDIGVTKRPFFVDKAVAIAGDGSVYPTEVEQVHLTGYDTLVRIFAPKYYAAGDLSVLSPFFSLHRLRVTLRPGGSWGDREEQLSFLSNLAKGATEDIGAKREWASRIELVESNAVDSEPISSTTARNAAKDGLELLSKLVTPRVLEYIMSKHLYATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9L7</accession>
    <name>D4D9L7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022069.1">
        <property type="nucleotide sequence ID" value="XM_003022023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9L7"/>
    <dbReference type="GeneID" id="9578953"/>
    <dbReference type="KEGG" id="tve:TRV_03810"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_2_1"/>
    <dbReference type="OrthoDB" id="4170704at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="209" mass="23633" checksum="A170D3EE3CFDE505" modified="2010-05-18" version="1">MMEDHVQDIAKEAVIYRRIGPHERLVRLVSHSSDGIILEYMPNGDLKRYLQSHESSSVPTSLKLTWAYQVSEAVQLLHNNNILHCDIKPRNLLLDNELNIKIIDFSGSSLDGSKPTSGEGTRFYLPRDWREPPTIATDLFALGSTLYEIFQGNSPFEDIPSDEVTTRYEAQQFPSVTDIPCGEIIEKCWRSEINSAQEVQTAIGNLVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M2</accession>
    <name>D4D9M2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022074.1">
        <property type="nucleotide sequence ID" value="XM_003022028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M2"/>
    <dbReference type="GeneID" id="9578958"/>
    <dbReference type="KEGG" id="tve:TRV_03815"/>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="123"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="275" mass="30237" checksum="5771F68227C21AFC" modified="2010-05-18" version="1">MSNHGTIKQVVDAVKDLVHDCNFDCNDSGIALQAMDNSHVALVSMMLKAEGFSPFRCDRNVALGINLVSLTKVLRAAQDGDVLTLKADDTPDVVNLLFESVEKDRVSEYDIKLMDIDQEHLAIPETDYSATVEMPSAEFRRICGDLNQLSESVLIEATKDGVRFSCQGEIGNGAVTIRQNTNVDKPEQNVSITLTEPVALTFSIKYLLNFCKATSLSSKVRLSLSAEVPLLVEYTLEGSGYVRFYLAPKVSSSLSKPVLHESSTVLTRWQIGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S6</accession>
    <name>D4D9S6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022008.1">
        <property type="nucleotide sequence ID" value="XM_003021962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9S6"/>
    <dbReference type="GeneID" id="9578892"/>
    <dbReference type="KEGG" id="tve:TRV_03869"/>
    <dbReference type="HOGENOM" id="CLU_858398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="324" mass="35993" checksum="478B5261D76C72C0" modified="2010-05-18" version="1">MAAAAAAAAAAAAASGGGVGGCGCGRGGRGRGSEVEAGRRDVAGGCRPGRGLRPQNPAHPLVRDARRNIEPALMHRKRPGLRRAAVESWRRVRRTPETIAQWTQTRQNSSFFASSTVQPWRRDAAAALLLRRRGQPSAGFKEKKKRKGIAGGKRKQPERQREGNRRRCERARDEEAEEKETPGMRPAEIDLLQQLIAESLRRRAGGGFCVCVCVFCCLSRASKHDLDSSRPPPLSLRRPVFLSSFGRDAGSTDQQVYRRYKHCGEISHLIRYCYVPGQGKRSLFERYLNVKPTEIGYYTKPLQVDKGADKHDTTHTHAEREKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S8</accession>
    <name>D4D9S8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022010.1">
        <property type="nucleotide sequence ID" value="XM_003021964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9S8"/>
    <dbReference type="GeneID" id="9578894"/>
    <dbReference type="KEGG" id="tve:TRV_03871"/>
    <dbReference type="HOGENOM" id="CLU_1251468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="221" mass="23537" checksum="A8876C4F9FBD8133" modified="2010-05-18" version="1">MLSRSIRRPICSYVCQSCLSRRITPSSTVIRRHNHATLPIQPDASSQSNSIEVKPNEGGSNEGSGAEKSSGGKKKGKGKEKGDANKASKSSKDVPLTQSANTQIAPEVEAKPAKTRKSKSKARKKKAAAQAKNLANLAGTSDENIKNMILIQQKSKLRLKKLRPSKVIAALNLAAQNGKSKSGKAAKGGLDEFAPVRSASPKLTSEVTLGDIEILRELVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9X0</accession>
    <name>D4D9X0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021965.1">
        <property type="nucleotide sequence ID" value="XM_003021919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9X0"/>
    <dbReference type="GeneID" id="9578863"/>
    <dbReference type="KEGG" id="tve:TRV_03913"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="477" mass="54147" checksum="308D8822D0878B83" modified="2010-05-18" version="1">MFGNLLQLGDSHAKRAAAWVKEYGPVFQVRLGNRRVIFANTFESVKYLWITHQSSLISRPKLHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLESTTSIKELLADSKDGTVDIDPNPYFQRFALNTSLTLNYGIRIDGSIDDELLKEIVTVERAVSNFRSTSNNWQDYIPLLRLWPTSNSQSVEFRERRDKYMSKLLEMLKERIANGTDKPCITGNIIKDPEAKLNEAERKSICLTMVSAGLDTVPGNLIMGIAYLASEHGQEIQDRAYEEIMKIYPNGDAWEKCLVEEKVPYITALVKEVLRFFIVIPICLPRVSIKDITWKDSVIPAGTTFFMNAYAANYDSNHFKEPFEFRPERYLDVADGTGTPHYAYGAGSRMCAGSHLANRELFTAFLRIISAFTIVPAKDRADDPVLDPIDCTDNKTSLTLDPRPFKVGFRVRDRAKLDQWIRESDERTKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Z1</accession>
    <name>D4D9Z1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c mitochondrial import factor (Cyc2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021948.1">
        <property type="nucleotide sequence ID" value="XM_003021902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Z1"/>
    <dbReference type="GeneID" id="9578831"/>
    <dbReference type="KEGG" id="tve:TRV_03934"/>
    <dbReference type="HOGENOM" id="CLU_003827_6_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="42962" checksum="D6323BC4293274A3" modified="2010-05-18" version="1">MFPRPVRLCRLSSIPRQCNVNSQFLSANRHQHSRNSSTTSQRPSKGPSGKLWLTAAAVAIAAGGAGIYTRSQGDTSSTTLDPVTFTNYELISKTPVSSTCSIFNLRPKREGGINAEVYQDAFETGIWSVQFKQPQLQVGRDYTPLPPSMQFSSLDKGNDTSLQFLIRKDGEVSSYLHDLQPGSIVEMRGPQLGLELTPDVQEILFIVGGTGIAPALQATHTILKCMRPRDETRIHILWANRRREDCLGGRSDTVGSQWSWWSKLYPTTKAVDPGENIEERRNYVVEQLDELKRLYPKKFTVDYFVDEEKSLIGKDSIMKYINSRAQHPLVGPRKKKLIIISGPDGFVSYLAGPKMWHNGREVQGPLRGILKELNISGWSVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAC6</accession>
    <name>D4DAC6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000206">
        <property type="protein sequence ID" value="EFE41207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021825.1">
        <property type="nucleotide sequence ID" value="XM_003021779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAC6"/>
    <dbReference type="GeneID" id="9578705"/>
    <dbReference type="KEGG" id="tve:TRV_04073"/>
    <dbReference type="HOGENOM" id="CLU_621413_0_0_1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="442" mass="48235" checksum="070F80F5A4EFB111" modified="2010-05-18" version="1">MSTAWQRVLRALVVASVISIILIYSARQFGPAPAHTPIRDRPDDQHKPFQPPAPEPDQEPPSLISHPPPVVPTLASSSTGTPGTKPPSTSSGTPTTSAAITTPSSHSGNANETIPGIPSKIWQTAKHANLSSEYADMSNTWIVKNPTFRHELLTDESSDDYVRSRYPGSDIVALYTSLKIPILRADMLRYLILLAEGGIWADLDTTCEQPVSNWLPSEISSSNSIIKAGLVVGLEPDADHGGKKILTNAVLAAQPGSKHIKAVVDDVVHQLLDIAKQKGVGPEGITLEMISDVVEVTGRKKMTAKIIESLSKTLNKEIKDGDLVKNGSNEPQCLDDIIILPVPAFASYNNPTPQGRVLVTHHHAGTWKSAAEDAKKNREKQLQEEADKLKKAADEAERKQKEEAEEQKKKEDAMKKSKEDGEKQRKEQEAKEEAQRKANDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAD2</accession>
    <name>D4DAD2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000207">
        <property type="protein sequence ID" value="EFE41193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021811.1">
        <property type="nucleotide sequence ID" value="XM_003021765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAD2"/>
    <dbReference type="GeneID" id="9578689"/>
    <dbReference type="KEGG" id="tve:TRV_04079"/>
    <dbReference type="HOGENOM" id="CLU_1788216_0_0_1"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="145" mass="16051" checksum="7DDE316511A7DAC4" modified="2010-05-18" version="1">MMNGDEDGDDKQTEGGFEVKGYREKQRRGEQPGSQPKKTCFVTVGATASFNAMIREILHLDFLAALKANNYTTLTIQYGRHGDELFRSFVKDNENEVLHNYGLTLTGFDFDINGLKDEMCAAKANPSTNTAEGLVISHAGKLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAI9</accession>
    <name>D4DAI9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021805.1">
        <property type="nucleotide sequence ID" value="XM_003021759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAI9"/>
    <dbReference type="GeneID" id="9578685"/>
    <dbReference type="KEGG" id="tve:TRV_04136"/>
    <dbReference type="HOGENOM" id="CLU_011017_4_0_1"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="585" mass="65734" checksum="D5C9B4341BD3F559" modified="2010-05-18" version="1">MSKRPRHIACRTCRERKIRCDGQQPCSRCAGQSQSCVYTTPSSSDAGTSDLTQQLQMMNDRLRRAEAQLANQACWAITEDPLATPGTYPYTSWPTNTIQSPIPLSPSSYMALPIDMESPQPEWALDTFAGLPPVTQPSSGSSTSSSFSIPHSTYEDRILSPQNMLKLQEAFFQSHGHLFPMLDQWRHLANPVVIQSEPWKSSIYYAICTHGALVSGNPSLEEACYHRARRELELSDMGGPGSQFFKIETLQASLLIALYEFRRSYLPRAWISHARCTRLVQLLGLQKLDRVGAPEEDEVELEEKRLTFWATYVFDCLINISFGGSLAFSEREISTRLPRYIHQSSDILPPQHPFTLSHLLQSPDISPMTPYMATIIIVTTWAKTLKHARDADSYELDDQNQQQFWASHQALDATLNRVEACLGDLTQFTLLADPTVSFLNAARHAAAISLYQTAITAAVPARLPVALIESWQLRCQNSAMEIITLSGVMLEGNLLHNVKHFNPFILLSIYTACAYLARVIRTGSPDSRILDPIESTLRSFNRAEIKTANPTLDVFLPRIFKDIEDTRMFPEPIIDPSLWLLNPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAL4</accession>
    <name>D4DAL4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000211">
        <property type="protein sequence ID" value="EFE41113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021731.1">
        <property type="nucleotide sequence ID" value="XM_003021685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAL4"/>
    <dbReference type="GeneID" id="9576812"/>
    <dbReference type="KEGG" id="tve:TRV_04162"/>
    <dbReference type="HOGENOM" id="CLU_016576_0_0_1"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="736" mass="79768" checksum="F15EB3BEEF787014" modified="2010-05-18" version="1">MARPPERRERPDTTRLVPRRDATCSPDNNAGKDCGPGLTETPTVAIALGVVIPLVCAFIVFFLLHRRHVKKLRKEDEQDKIKALDYGLDDVPASNNGAKVRTGGGQGVEKNGDGHKPGMSMDWAMDSPYFLPPGLQKSRGSLHSLSRTIPGEDKYGIAFDGNGSIRSNTPTRRHNNADDASSYTAGSSRRVGGADGQHHHNGGLGDDMSQNLLRNAQRMSTSPPLAAVPAESPSPPQPAHLPFDNRFDELGLPSSISNNYNNNNNHKEITNNSDNNNSGTSSNTGDDNHQMGAAGSKDPALRSSHNYLGQFIHSGSRSSTPDDQKKQVSASNQQDGHPSLPGLAFSANDGPKLDFNLGPSSIPAATAVTGHQQGDADSDYGDETKLASGLPQFNIMPAEEQQQHQQLHGDEYGHGYPEEGDDGTDSIHDVYDQYYDSNHLIDTRRLTMGIRPLPPEDPSDNPEQRANRIRSFYKEYFDESKPFQQDYIEDYGDVPPLPNPAAPFAQPLPRRAMTPPPRMPPAFPPRRHPGVGHQPPPGMGGMNRGFAHSATNSLASGGHPMGGPRAFSSASGRIPHPRQKKPLPPPSPLHILPTPHKLKDDTFLPIDFAPGPRARDRQAGRPETPLGGLQHYNLMVPSHSPLVSSFDELPSVPSPHALRKSGTYTALDFAPPPRFKNESGTGSDAGSIRSNRTGISALQAHNIRSGAYRVSRLPADTVGTRDDFSSNLKPQWEMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB06</accession>
    <name>D4DB06_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021563.1">
        <property type="nucleotide sequence ID" value="XM_003021517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB06"/>
    <dbReference type="GeneID" id="9578526"/>
    <dbReference type="KEGG" id="tve:TRV_04305"/>
    <dbReference type="HOGENOM" id="CLU_350974_0_0_1"/>
    <dbReference type="OrthoDB" id="4173511at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="803" mass="88105" checksum="D5A8161866AE2CF7" modified="2010-05-18" version="1">MARSIRKTQNELTVSTGGSSDWRSLDNELTETGLDADESSASTGQKIADGFEKDYAIGISSLLTPVRPKPFRSLPNDIPKKRTKDFISNSRSEGHSTTAHHIKHNVNTKDSEGPKAALIQDTLSRGLADKKPYPLYPSQPTSDLNITAELRKLWDKPTLKPHPFPRLPDSSIKPNIKEPPSLNDRARFHNTTKTNKTIPNPSSGRSGSSRFGARIKHIDGTSDTPRAGRRRFHPNSPSSPIHSDMLYDDGTSSIIHTSTGICPPIAYGSRRVVASTPGLPLPHSRTEGHSSDGIHCPRPSSQSCNVPDTFWNGWDHCYNSSKIAYPAPVQLFESDTTTSKFADSRPSKQGLGSIPRPRAPLRDLSSNGLKIRDTLGKEAQTRRASLASSQKENLRPRKRSRDTRQNSPIGGGEDFTREVSEIFTNFADTLTGNRKVPSSPASDSNTGHLGKQATRFHRNKSNGNHDFLSSTDVSSNLDSKHYDETGTVVRNPETSLLPFGAPDTTADTYAGDKLRRSLPRTARFSRSRYSTASITDFHPAGVDLTLTVSTDISSTPFGQGATVDNTHHREPDKPLDMLSDLQSRLQRLEIERESLNQSIRQLNRENLALSARVQVLEAAKSTGGVGREELNNEDLSMHILLQPVGKGKRSPETQAQMPTSGVTGLCGQEATDEKTCRFQDETDVLEATDLSTRTANAGESVDPICGSLGEAHVDYTILTLVDDHEVEELRRSLEASRIDRTAGKIHHISSAKHDISMPPLSQVLANIGVGVEKEEYHSSASEEDMCTLPPIKKWVRRGLQKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB35</accession>
    <name>D4DB35_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021487.1">
        <property type="nucleotide sequence ID" value="XM_003021441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB35"/>
    <dbReference type="GeneID" id="9578468"/>
    <dbReference type="KEGG" id="tve:TRV_04334"/>
    <dbReference type="HOGENOM" id="CLU_1636643_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="162" mass="17833" checksum="8B74C211CFAF24B0" modified="2010-05-18" version="1">MIFKLDSGKPTLTAMMMQQMLTYGLNLSPTLAHFQNIPKNLRKLARSLLLGIIQNGDSSIPWLSSRTSIFYESNCVPAMHFLSASVALKKKVDSGPSVGHVMQHDLDARACRVTSELSALSLLDFFSVLTIGNTNNTDSSFARNTAVEGRTFGFFYASEKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK7</accession>
    <name>D4DBK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat protein poxJ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Oxaleimides biosynthesis cluster protein J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021433.1">
        <property type="nucleotide sequence ID" value="XM_003021387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK7"/>
    <dbReference type="GeneID" id="9578393"/>
    <dbReference type="KEGG" id="tve:TRV_04507"/>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="38851" checksum="9456288D94BFDCDC" modified="2010-05-18" version="1">MAFNSASTGVTNQGDISKDVTLNNQPEDSIAEVSWSPVANYLAVASWDKAVRIYDISHYPQGKGKALFSLPGAALSCGWSSDGTKVVGAGTDGSARLIDLASNNSQAQQIAQHDAPIRTVRMVQVPGSQSPIVVTGSWDRKVKYWDLRQSTPIGAVTCPERIYAMEASGNKLLIATADKHLALVDLNQPTTIARTIQSPLKHQTRAVSWIANGTVYGVASIEGRCAINYVDESNKNQNFTFRCHRQPKDNDPKNQLVYAVNAISFHPRYHQVFSTAGADGTFCFWDKDAHHRLKGFTAGGPITSTSFNHDGSIFAYAISYDWSKGYSHNTRDHPTKVVLHPVSDAECKPKQKTNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBW0</accession>
    <name>D4DBW0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-reducing polyketide synthase nscA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Conidial yellow pigment biosynthesis polyketide synthase nscA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Neosartoricin B biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021298.1">
        <property type="nucleotide sequence ID" value="XM_003021252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578143"/>
    <dbReference type="KEGG" id="tve:TRV_04611"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_0_1"/>
    <dbReference type="OrthoDB" id="4170918at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF40">
        <property type="entry name" value="NORSOLORINIC ACID SYNTHASE STCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="299"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1547"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1653"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1189"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1525"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1742"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1750"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="1221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2040" mass="222818" checksum="88DDB22EB09EF234" modified="2010-05-18" version="1">MNVLKDESMLMNMPLFYCSQHEGLGQEYFSPQETCVSGICTGALSAAAVSCCRTASELVPIAVQTVLVAFRLGMCTLRAAKAIDPSEGNWSMVVSCDSTDKVEELLCKFSESNNLPITSMPWISAYGEDNWVSISAPASILLALRSSEILSGMRSRVLDIHSPYHAKHIFSNSDIDAILETTDSQEWERYRAVRPMVSSTTGEVIEPEGLRPRLEAALIQILIEPIRWTELTQGLAAFMSSINATRFHVISIGTNAEATLTASLSSKMQLDDSQVPGNGESVKPDQNGGEARGNMVRGRSKIAIVGLSGRYPSAENNEEFWDLIFRGLDVHKTVPDLHWSAKTHVDPTGKKKNTSATPYGCWLEHPEAFDGLFFNMSPREAPQVDPAQRIALMTAYEAMEQAGIVPGATPSTRHDRVGVFYGVTSNDWMETNSAQNIDTYFIPGGNRAFIPGRINYFFKFSGPSYSVDTACSSSLASLHIACNSLWQRDIDTAIAGGTNILTNPDFTAGLDRGHFLSRTGNCKTFDDDADGYCRGEGVGTVILKRLEDAIADKDPIHGLILGTYTNHSAEAESITRPHVGAQRDIMRNILSNSGVDPYSVSYVELHGTGTQAGDAREMTSVLDTFAPADARRYRQPEESLYLGSVKSNIGHGEAAAGVSALIKVLLMLRNNTIPPHCGIKNKINSSFPTDLDARNVYIAKKAVPWPSKEGQPRRVFINNFSAAGGNSALVLEEKPVEAEILGTDPRAAHVVTVSAKSAISLNRNIQSLADYIEKHQDETLFLPQLSYTTTARRIHHQHRVAVTGASAADIKAALKTAAANGDGKVRARVAPKVTFTYTGQGAQYVGMAKQLYTLFDQFKRDINRFDSLAQKLGFPSFLSVIEDESSQQQHDISPVTLQLSSVCHSLGEYAALNTAGVLSDTDTIFLVGRRAQLLEQHCILGTHSMLVVKASLAAVQRALDGTEFEVACINAPEETVLAGPNKQIEALKESLNNNGLKTKIISVPFAYHSSQVDSILNHFETLATGVRFRKPAIPVISPLLAEVIVDEGIICPRYLRRHCRETVSFLGALQHVKETGVVKDKSFFVEVGPHPIVTGMVKALFGTSVTSMATLQRSRDDLKVVTELLVSLYSAGTDLRWNEYHRDFEASHKVLELPAYNWDLGNYWMQYVNDWSLRKGDPPLIVGPSSLTSTTIHKVVDDSIDKIVVESDMAREDFNPLVQGHEVDGVPLCTPSVYANIALSIGKYLLERYHPEIETNLVDVANMTVLKALIARAQGPQPLRTIATVDWSAKKAGVSFRSYDKSGEPTVEHATCEIHFTDRSRLKLLEGSTATIKARMGAMRETLGSGETQRFNRAMVYKMISPLAQFHRDYQPLDEVIIDSNSLEVSSQVNFKGVQAAGNFFAHPAYIDGLTQAGGFVMNCNDSNDLAVEVFVNHGWESLQLYEPLQKEKKYKTFCHMSPGDNRKFHGDVVVFESEKIVASYKGIVFQGVPRRVLRFFLKPEAPAAPRGQANQKTTARPAPVAPVATAMPTSTSKPIAKPAMAPTTASAKSPKVKQAFQIISEEAGVPVEDLTDDCVFTDMGIDSLLALVITSRFREELELDGELDDIFLTYTSGKALRSYLANQSGSDIPVVVEPTPLPVIALNVEPAVTSRISMGADCAAALAIVSEESGIAIAELADECILAEIGIDSLLALVIVSRFKEELDVDIDSQSVFTDSFTIRDLKAFFGKGESTITTRAPSILMESSDENTMSSMTPPDSSSDYDTSEKPEHIAVPPATSVLLQGIARHAEKILFLFPDGSGSATSYSAIPRLSPRVAVIGLNSPYNKIPELFRCTLDDLIDSYIDEVRRRQPTGPYYFGGWSAGGILAYRAAQKLIEAGEKVPDLILIDSPVPRGLDKLPQHFYDHCSKYQVFGHRAGPTKGHAKAPAWLIPHFNATIDTLHDYHASPLPAGKTPRTTIIWACESVIDGVNVPKLQSHPDDTPGMKFLSEQRTDFSAAGWEAVFPGGEIILERIERANHFSMMKGEHASKLAAIIKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC12</accession>
    <name>D4DC12_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021232.1">
        <property type="nucleotide sequence ID" value="XM_003021186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC12"/>
    <dbReference type="GeneID" id="9578077"/>
    <dbReference type="KEGG" id="tve:TRV_04664"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="10">
        <location>
            <begin position="54"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="584" mass="63887" checksum="6CAD72DBF66ADE5A" modified="2010-05-18" version="1">MAEEKSTKNSLAALRESAIEVVKGLADTFEDGLDTFAVRNAILPSREERPSRFIGAIDQGTTSTRFIIFDLQGSIAASHQTELGRVHDQPGWHEQDPAEIVSSAQKCIEQATKTFINSGHDISEIEVLGVTNQRETTVVWDWETGKPLYNAIAWPDTRTKSIVREFKEKGADQLQEICGLPISTYSSSAKLVWLLRNVPEVKTAYDAGNLAFGTVDTWLLYNLNGGKEKNVFVTDVSNASRTMFTNLHTLKYDDKLLNFFGLDQSKLRLPKIVPSADPTAFGQLATGVLKGVRIMSCLGDQSAALVGHEAFEPGMAKNTYGTGCFLLYNVGEKPVISSHGLLATVGYQLGANSKPVYALEGSIAVAGSGVNFLMNNLGFFRDARRVDDEASSVQDNGGCVFVTAFSGLFAPYWIDTAKGTIFNETKMDNGGRRKKAVILTVYRLVGITQHTKKGHIARATLEAVCFQTKAVLDAMERDSGQKLAELRVDGGLSTSNVCMQLQSQADIIRIPVKRPAMHEVTALGAAIAAGIAIKIWEGPRNLDGLKQSDKTVFEPKLPEEESNRIYKKWSKAVEMSRGWMDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC84</accession>
    <name>D4DC84_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000240">
        <property type="protein sequence ID" value="EFE40539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021157.1">
        <property type="nucleotide sequence ID" value="XM_003021111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC84"/>
    <dbReference type="GeneID" id="9577999"/>
    <dbReference type="KEGG" id="tve:TRV_04736"/>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="420" mass="46755" checksum="25D1AE8D94F14BF3" modified="2010-05-18" version="1">MEAWFRENIIKHKVVIDTDRANEVKWSRDNSIFADVLLRADEDDSENEESQETKKCENGSLEGAGSGIPIGGFSRLSLDTPMKKPKRKSVLFPAHRAMLLRSEFFSLMFSSSFREAQVTDYLQIIPIDCSPDVLDIVLTFLYTEKADFPLEVAVDVLFAADLLLIERLKTKAAVLISILGSGNITSLSSKPSADTKESSPTKEGKGAKGSDEIIDVYEILRAAWLMRIQRLEEFAARYFAYRLEAHINNPEFAQLVKESAERIQKRQETDSIELVDDIRYYLSERFRLRFEDSGIDILNSEDNPNEGDPAGNTNTSSNSSPETTSNGNAISPTPLSPPPSSFNRKPSDVDSAREQQGDTHNIVNAGPPKTNGKSEQSHASGVIRTLDGREAGDEFSRDAIDYELLLNKLDQLLEKLGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC92</accession>
    <name>D4DC92_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_04744</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021130.1">
        <property type="nucleotide sequence ID" value="XM_003021084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC92"/>
    <dbReference type="GeneID" id="9577972"/>
    <dbReference type="KEGG" id="tve:TRV_04744"/>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="96"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="408" mass="44006" checksum="867E1A3BD229CF30" modified="2010-05-18" version="1">MAARSLPRSLSRQLALVRPYGTVQSSIPKPVASASSPAAVAPSPTSSLPAALQDAIAASAPRTSWTREEITQIYQTPLNQLTFAAAAVHRNFHDPAAIQMCTLMNIKTGGCSEDCSYCSQSSRYDTGLKATKLSSVDSVLEAARIAKENGSTRFCMGAAWRDMRGRKSNLKNIKAMVSGVREMGMEVCVTLGMIDGEQAKELKEAGLTAYNHNVDTSREFYPSIITTRSYDERIQTLGHVRDAGINVCSGGILGLGEEDSDRVGLIHTVATLPAHPESFPVNALVPIKGTPLGNRKMIEFDKLLRTVATARIVLPATIVRLAAGRISLTEEQQVTCFMSGANAIFTGERMLTTDCTGWDEDKKMFDKWGYYPMKSFERGEYKGIAENQSSSVSNVVAEPAQPAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCF8</accession>
    <name>D4DCF8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_04811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021098.1">
        <property type="nucleotide sequence ID" value="XM_003021052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCF8"/>
    <dbReference type="GeneID" id="9576745"/>
    <dbReference type="KEGG" id="tve:TRV_04811"/>
    <dbReference type="HOGENOM" id="CLU_000688_6_2_1"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="48890" checksum="51F347F9BE31B798" modified="2010-05-18" version="1">MPSATGQNWEKYKKNFADDEEPEKKITPLTDEDIHVLKTYGAAPYAAAIKKLEKQIKDKQASVNEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPLQVARCTKIIQDEKDAEKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDPSVTMMTVEDKPDVTYGDVGGSKEQIEKLREVVEMPLLSPERFVGLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDSRGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDLDGRANILRIHAKSMSVERDIRWELISRLCPNSTGAELRSVATEAGMFAIRARRKVATEKDFLAAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV9</accession>
    <name>ADMB_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Disintegrin and metalloproteinase domain-containing protein B</fullName>
            <shortName>ADAM B</shortName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ADM-B</name>
        <name type="ORF">TRV_04965</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable zinc protease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Membrane</location>
            <topology>Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EFE40271" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40271.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020889.1">
        <property type="nucleotide sequence ID" value="XM_003020843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV9"/>
    <dbReference type="SMR" id="D4DCV9"/>
    <dbReference type="GlyCosmos" id="D4DCV9">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9577741"/>
    <dbReference type="KEGG" id="tve:TRV_04965"/>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397721" description="Disintegrin and metalloproteinase domain-containing protein B">
        <location>
            <begin position="24"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="24"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="728"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="271"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="519"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="395"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="798" mass="86572" checksum="BD27A9326ACFE42A" modified="2010-10-05" version="2" precursor="true">MKAFSCLLAVIATAASLFQHVDASHARDKLNNISRVERPVIHTPSRRVHAHSHFDLTFDLYPRRNRIKLQLEPNHDVLSHNARVTFLDTEGNVDRIERIERRDHSVFKGWAWTQAKSGVWERVGWARIIMHRDGEDPLFEGVFTVMHDHHQVIAKSKYVRKRHQQDPPLDNTPGEYMLLFRGSDIAQTQSTGNVERSIMSSPSCDADTLAYDSNSNFMFPPLPEENNTSIWNYFMTSIGKRQMTDTGGVVPGSRDLKETIGSTSGCPNTRKVALIGVVADCTYTNTFASEMDARADIISVVNAASVVYEHSFNISLTLGEINILPKNCPATASSATPFNQQCDDRAGGGSFTLADRLNTFSAWRGKKTDDFAFWTLMTDCTTENQVGLAWAAQLCVKGVQGNPDSRNSSSQAVAGANVVSKTDNTWQVFAHEAGHIFGAVHDCDSMLCQNPANPDNSRCCPATASTCDARGRFMMNPTSGSQITNFSPCSIGQICSRMARRTILTNCLTTNRGVDTISGQQCGNGIVEDGEDCDCGDEESCKGNTCCDPKTCKYTSGSQCDDANEECCKGCKFASSSTICRTSSGPCDPEEKCSGNSGDCPHDIHSKDGGTCGTDLQCASGQCTSRDLQCQMHLGNQVAGSRTVAFDSYGCEVACKDPDRPNVRYEGSLTFLDGTPCGGGGTCKNGQCSGSTFGNEVSDWVSRHKPIVIGVAVGAGCLLLLAIASCICGRSRRQRPRNRKMPPINMRPMAPAYNGWNGAPPNAQQSSPGGHPPYNNIPPPINAPPPAYPGHMPPTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD52</accession>
    <name>D4DD52_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020833.1">
        <property type="nucleotide sequence ID" value="XM_003020787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD52"/>
    <dbReference type="GeneID" id="9577572"/>
    <dbReference type="KEGG" id="tve:TRV_05059"/>
    <dbReference type="HOGENOM" id="CLU_031464_0_0_1"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="616" mass="66478" checksum="0808E2E3D2B00C2E" modified="2010-05-18" version="1">MQLNLGITADAAAVHRHEYSASPETQQGASSTFFPSARSILSLGFASLTKQGASAPSSTSKSESQAPMAQNTNTYRSIVPSGSVIFQEPTAMEETVAHTESGSDSPDACGIVDGSVDGASKKHAHRSKTILRFAHPPPTTRHKRLRIRPRLLLQLQQVSNTSRPISVLDVVPSSLFKGRAQRKISGPFAARDRVCTSDLIVLPSDTYGPAGAGDEEQRPEGDSANENREPIATISQIRKDDSKSKPTAEICLADGLCWISESLPNGSYEFTATDEHGIKKCVRWVVRGKRNRSTSIQGAGRQSPGPEGGKRLTFSIIDPQTRRHPIIGWLCRTGIEVLDQESLSSVYADRKTNQRPESAPAETATRQSPVVIDDKIRQLITITGIWVAFQEGWVGNPLVTSNIESSSSNGLSVSQLPPSSVVAAERPPNAGVGETQPDELPTRSNSNRTNTRTSLTSRIRQKGRRATAPHTRSSSIQKQSPRRSCSDDGVSKGSGPSTPTHTRSCSMLCSANQESSPQSHPHRPVQTIHDLTDLETPDEMNDPLHYSNLHSSQGQTPKHNSRQSSPVRGATSPGRDRASTPDQSTTSSAGSREKKGWRKLGTLLGAVRAKKTPKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD53</accession>
    <name>D4DD53_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020834.1">
        <property type="nucleotide sequence ID" value="XM_003020788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD53"/>
    <dbReference type="GeneID" id="9577573"/>
    <dbReference type="KEGG" id="tve:TRV_05060"/>
    <dbReference type="HOGENOM" id="CLU_772058_0_0_1"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="359" mass="39611" checksum="431A7CBB65C1AE5E" modified="2010-05-18" version="1">MKAHQGTPARADTKLLRNSCDTYIPSYYNKASENDIDALLAEGKAAVVSSHCGTSRDDNTGPVPPYETSDGSLQIRGAASAQQSYRKGIEDNSDNTSASDATIRNVEHNRPAIPLPEKPPAPQPPCTPPHGSLQQPSPGKIKSSPTYNQLMPLISPILSSLQGGKETPPSTTPPNDLQSLCIPQPEFQNLDHQTQQDIHLWLLFTGYYDEEYRIETISRRREIVAVHEKLTELMNEEWRKRRVFTNISSSRLSQSLFPCMMPAGARSATPSDSSAMRSRTVELPVDSPAERTPTVSDECLKAKAENTSSLQPTNNRVQPSPLKRSNTPPPEDSSCQRKVARSNEQTSTSREFKKQGLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD82</accession>
    <name>D4DD82_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000258">
        <property type="protein sequence ID" value="EFE40195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020813.1">
        <property type="nucleotide sequence ID" value="XM_003020767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD82"/>
    <dbReference type="GeneID" id="9577564"/>
    <dbReference type="KEGG" id="tve:TRV_05089"/>
    <dbReference type="HOGENOM" id="CLU_105488_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="57"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="199" mass="22019" checksum="DCB695E4B944E1D7" modified="2010-05-18" version="1">MSLQTTVLVNGTWATRTVDIGELLFRNRESDSISGRAEKAQTPATGILSRTLAQGPAVQWILPARLRHQDQNDVVFIGDKFIQIKELVPSGHLEEVVTKSDFDSRIIGAKIINSQPGPELEDQIKQGGRISSHSTQESQDEGKVPPHILVLVLSSKEILFMFTKPGSRGVPEFVYSRRPLPADTSALEEYGRHIAVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF47</accession>
    <name>D4DF47_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000330">
        <property type="protein sequence ID" value="EFE39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020151.1">
        <property type="nucleotide sequence ID" value="XM_003020105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF47"/>
    <dbReference type="GeneID" id="9583917"/>
    <dbReference type="KEGG" id="tve:TRV_05792"/>
    <dbReference type="HOGENOM" id="CLU_039317_1_1_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="258" mass="28133" checksum="63553590BF8B8A4E" modified="2010-05-18" version="1">MPSPSQHGVVRDLQQQPVMIPTPMVPPQLPPHFSSTSLPLPYPGDRHGVKRRRADDGRSGGSDETASGIGLSMLPESSHADEQHSSEMLLPTPGDHSSHHPHALQHDYHQTSPIHQQHHHHRLPSQATLAAVQGSDGELTSPGGGTGSQSVVGQPGMPDPAPRPRGPKLKFTPEDDSLLVELKENRNLTWKQIAEFFPGRTSGTLQVRYCTKLRAKATVWTDEAVCPFALTRAFLIPVLPLTFSEPFPLFSKLKSTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFC3</accession>
    <name>D4DFC3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020096.1">
        <property type="nucleotide sequence ID" value="XM_003020050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFC3"/>
    <dbReference type="GeneID" id="9583860"/>
    <dbReference type="KEGG" id="tve:TRV_05869"/>
    <dbReference type="HOGENOM" id="CLU_024874_0_0_1"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="64131" checksum="102DBEA9A5EFDED8" modified="2010-05-18" version="1">MTEAQKYQGALYKEKPAKNTKKKAVTIAEDAVVKSLNPYVEDAPDADDDYKGAPPPAPSPPPFKNTDTTVAKPRSEKIDVFDFLDESATPNASRTNLNESMTMVEHAPPIFDSPKQLARIDGDRDEEEDTGYDVAYEENGFSYGAGPIPPAPPYRHDSNLSTASTEFMTPAQKWERERQQWLHDRNARLNMNRPPPSLERHRTDSNMSNMSLTTSDKKRKRGQAGPSDANLTTPGGYDYEADTPMMDAAAAAGGHTSYHDRPPPILHSGLTGNLSRMMRYSVSPDYSDEYRSDYSRGHGEPNSPIKRSKRTKEPVGSGENGLGISMKGQGRTTGKLISLLGAGATIDPATKALVRTKRRTSEGSSAAAAPAPAPAPAPAPAASTSRELVQTKKTKRPKTRQLSEVGSSSSKSRRKVSAGNGAEDSDSERPEKDQRKMKAIEYKRSTDSDEGAAKRSKTTDNSQMVLYKNGSAQPGHDSEFEENLRFEKASIFLSLVNKGPDSERGCSVHKILKRYHRLESPSRSGSPESKDKDGKESSRGSRRGRGRSRAEEKERKEEEEQQLWRTLRVKRNDNGEMVLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFF4</accession>
    <name>D4DFF4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000337">
        <property type="protein sequence ID" value="EFE39416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020040.1">
        <property type="nucleotide sequence ID" value="XM_003019994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFF4"/>
    <dbReference type="GeneID" id="9583810"/>
    <dbReference type="KEGG" id="tve:TRV_05903"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="63"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="41816" checksum="88CA3B83110ECDC0" modified="2010-05-18" version="1">MPAVETAPITGVNYTPEEVIHTPEEVIHAYQEIHDFVDCTPLHKVESNSTLAKFLNTRVSDAAPNVSIELYFKLENLQRTNSFKIRGLMCCLSRMSDERLKRGIVVLSTGNHAFASGYAASLLSRMRGIQIPVHAFMPPTASKTKVYLAESQGVQVHLSGNSVTECMRTAEAFAESLGTSVLAPADDYDIIRGHGSVGIEIIDQMQKHENFGATKPDAILVPTSGAALLAGTAVYCQPHGVNVYGTEPAKGSADLLAGRKSGKRREMVDSSVNTIADGLRSCVAPRAWPVVSNKTYVRDVFGVNDEQIRQALKFFVAETKTLAETSEVVPLAALLFSEECKEELGRLANNAENGKLRLVVVVTGGNVSLEAMVEVLMLDPRKNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFU8</accession>
    <name>D4DFU8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000343">
        <property type="protein sequence ID" value="EFE39278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019902.1">
        <property type="nucleotide sequence ID" value="XM_003019856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFU8"/>
    <dbReference type="GeneID" id="9584652"/>
    <dbReference type="KEGG" id="tve:TRV_06050"/>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="64"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="640"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134568" checksum="F32F0AEE93111EB8" modified="2010-05-18" version="1">MEEQSNRPHRKSKEKGKKKDHGGPNPKAFAVNNPGKLQRQAARSHDIKEKRLHVPLVDRLPEDPPPIIVAVVGPPGVGKTTLIKSLIKRYSKHSLTSISGPLTVVTSKKRRLTLLECPSDSLASMIDVAKIADIVLLMIDGNYGFEMETMEFLNALSASGMPGNVFGILTHLDLFKKQSTLRTAKKRLKHRFWSELYQGAKLFYLSGVINGRYPDREIHNLSRFLSVMKNPRPLIWRNSHPYCLADRFLDITPPTLKEENPKCDRTVALYGYLRGTNFPAIGARVHVPGVGDLSVSSIEALPDPCPTPAMDQAMAKAAGKNGRKRLGEKQKLLFAPMADVGGVLVDKDAVYIDVKTNTFNRDDDNEQAEERGLGEQMIIGLQGERKLLGDTAAGVKLFRDSGVAATINPKETENLGRNEKRKARFIEGDDNAHDLEEDEGDGLESAEEDEDEEQYGSDIEEESDDEVSGADFADKFREKQNGTSCSKNGEDLAFADSDSDLGSISSVEHQELESAPSDYEDEEDEDGETRWKENLAANAKVMFSKKPPYRVAELTRMLYDDSVNPADVARRWSGEDAMEEDQKDDEDEADGFFKKTNAEKGVLDDRMIPVYDYDELEKKWQDQENLDALRRRFASVKFSKNRTGKEGSGDDEDDDEEGGFGDSDSDDEGDGAFADLETGEVFGGDSKDNEEEDEEGESEPEDLNAERERNARRKEELKLRFEEEDREGFANSKDGARAGGQSQNEEQFGEDEWYDAQKAALQKQADINRAEFDALDALSRARAEGYKAGTYARIVLENVPCEFSEGFNPRFPIIVGGLAPTEDRFGFVQVRIKRHRWHKKILKTNDPLIFSLGWRRFQTMPVYSISDSRTRNRMLKYTPEHMHCFGTFYGPLVAPNTGFCCVQSFSNKNPGFRIAASGVILSVDENTEIVKKLKLTGQPYKIFRNTAFIKNMFNSSLEIAKFEGAAIRTVSGIRGQIKRALSKPDGHFRATFEDKILMSDIVFLRTWYPVKPARYYNPVTNLLDYKDSETGTGATWQGMRLTGEVRRDLDIPTPLEKDSAYRKIERQARHFNPLKVPRQLAADLPFKSQITKMRPRKKETYLQKRAVVLGGEEKRARDLMQKLTTLRNEKVAKRQAAQEERRKVYRAKVAENLEKKEAREKKERDEFWSREGKKRKNEAEGGSSKFKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG74</accession>
    <name>D4DG74_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GPI anchored CFEM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_06176</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019753.1">
        <property type="nucleotide sequence ID" value="XM_003019707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG74"/>
    <dbReference type="GeneID" id="9583687"/>
    <dbReference type="KEGG" id="tve:TRV_06176"/>
    <dbReference type="HOGENOM" id="CLU_063084_2_1_1"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056483" evidence="17">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="186" mass="18265" checksum="230AFF69B1895750" modified="2010-05-18" version="1">MKFSQAVIALAAATVVSAQLPDVPQCSLPCFLDALTTDGCSELTDFKCHCSKPELPAKITPCVKSKCPVAEQVSVSNAVVKQCSQAGAPVSIPPVEESSSKPSEPSTSEAPTASPTESTPAPTTPAPTGTGSPSGTGAPGGPSGTGTFTNTGVPTQSTPIYTGAASGLSANIGGMGAAILAIAAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG89</accession>
    <name>D4DG89_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC multidrug transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019768.1">
        <property type="nucleotide sequence ID" value="XM_003019722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583679"/>
    <dbReference type="KEGG" id="tve:TRV_06191"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="286"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="615"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="966"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1479" mass="161965" checksum="4E261CF0B19DAA3B" modified="2010-05-18" version="1">MGCSIRAEDAFGPAAAPECLDGFDFTLLFEESFFSIGVCSAMLLSLPVQLARLSHRQQQHNHHQQAPAGPLLYSKLTAHLVSTGIKLVLVALVLVPGRALATRATVAAVSIAAATSASVAVLSYWQHCRSPRPSTPVSLFLGLSLLLDAVRARTLWAVQPRVFCAVFIAGIVSDLAKFVLELLERGDDGSDGPDGPGRLPAETVANVYNRSVFWWLNPLLLQGFREILQAEKLSAIDRRLRGGDDDEEDSFLGQWEAAKVKTPAALVRLLAAHHLWAALAAVIPRLCLTGLTFTQPFLLARIVRYVTEEAAGDDDGLASRYGYGLIAAALLVYIGLAVATTNTQHKTYRLITMLRSSLVPLIYTQTLHLDTSAVRDSAALTLMSVDIERISSGLRYFHEIWASPIDIGLALWLLQQQLGVAAVAPAAIFLVCTLSGLLVAATMGARQRQWLEAIQNRVHATSSMLKNIKEIRLGGLQGHAAKKLQELRSKEISESRPFKKALVMIVTLSFTTAACGPLLAFTMYTLLALRNGSQALDYEKAYTSLSLLALLQTPMALILDAIAGFVAAFGAIERIGEYVSKPTTNASKASSTEMIPPSISTRPDIYEGKGKEVLVRAQGFSAGWNADLPFVVKNLDFEILRSTVTFIIGPVGCGKSTLLHSILGEVMHTDGSLQKSVTRVGYCCQEPWITNDTIRDNIIGSNLFQPTWYDQVIDTCVLRDDLQGFPYGDQWIVGSGGMALSGGQKARLGIARALYSRETLVLLDDVFSGLDAKTEELIFHNLFGERGILATENITIVLATNAAMNRLNYADNAIYLDSTGNQVSKDDALEKELSEGVTLAAPSEKRTSAGQSHENHIGATPELSSARPLTASAQEKERRVGDTTVYKYYIQVVHPMSAAFFTAVCVVFVLGLTLPHFVIKWWLQRDTEYTISHIELYLGIYAALAGMAIVSLAVAAWYDSPLWGYRSCLLEIHRYLTEHMLPRASRQFHEGLLSTVVDAPLQFFLSTDMGTTINRFAQDLQLADMELPLALFNTTVELITCLAQLIIIAVASKYIGVAIPVILTVFYLIQKFYLRTARQLRLLDIEAKAPLFSKFLETLSGLVTIRAFGWQKDYEHHNNQALNDSQKPFYLLFCVQRWLNLVLDLVVAAIAVIVVSIAVRTKGKIDAGSTGIALVNIVQFSTTIKSLMANWTQLEISIGAVSRIRSFSTDTLLSRPRERSPELKDEATGPTISPSWPEHGTIEFRGVTAEYEINSTPVIKNLNLLIHKGEKIALCGKSGSGKSSIISALFRILHVSEGNIIIDGVDISAIPQEILYTRLVCVTQTPYLIQGTVRENVDPSGTSSDEQVNQVLKEVTLWDTVIARGGIEVQLSDELFSVGQKQLLCLTRAMLRPGSILLLDEVSSSVDLHTNKLMQSIIRKHFATRTVITIAHQIFTILDADRVAVISNGEIVEEGQPTELLEKDPPGPFRILAAANMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ4</accession>
    <name>D4DGJ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_06298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019669.1">
        <property type="nucleotide sequence ID" value="XM_003019623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ4"/>
    <dbReference type="MEROPS" id="T01.011"/>
    <dbReference type="GeneID" id="9583586"/>
    <dbReference type="KEGG" id="tve:TRV_06298"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="275" mass="29749" checksum="75E1F00DD26AA6B8" modified="2010-05-18" version="1">MPGFDFSNYNRNRALHAKGVPLPKATSTGTTIVGCIFDGGVVIAADTRATSGPIVADKNCEKIHYIAPSIWCAGAGTAADTEFTTNLISSNIELHSLSTGRAPRVATCMTMLKQHLFRYQGHIGAYLVVAGVDPTGTHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFESMWKPSLTKDEAIKLASEAIQAGIWNDLGSGSNVDVCVMEKDKPTKVMRNYLTPNERGEKERSYKFQRGTTAWLDEQVITKADLARYVTIEELGGEEAVAERMDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHC2</accession>
    <name>D4DHC2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019411.1">
        <property type="nucleotide sequence ID" value="XM_003019365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHC2"/>
    <dbReference type="GeneID" id="9580127"/>
    <dbReference type="KEGG" id="tve:TRV_06578"/>
    <dbReference type="HOGENOM" id="CLU_038321_3_2_1"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25647" checksum="75E3E76EF6B4BBAE" modified="2010-05-18" version="1">MAPPLTDLSSTNRNSRTRGPFRPRAANKGSGSYQLRQFAEATLGSGSLRKAVKLPDGEDVNEWLAVNLVDFYNQINLLYGSITEFCSPQTCPEMKATDEFEYLWQDNENFKRPTKMSAPEYVEHLMTWVQANIDNEQMFPSHIGVPFPKTFPSLLRQLFKRMYRVYAHIYCHHYPVVVHLGLEPHLNTSFKHYVLFIEEHNLASGKDFWGPLGDLVDSMLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHL8</accession>
    <name>D4DHL8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_06674</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019270.1">
        <property type="nucleotide sequence ID" value="XM_003019224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577511"/>
    <dbReference type="KEGG" id="tve:TRV_06674"/>
    <dbReference type="HOGENOM" id="CLU_002979_0_1_1"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="647"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="312"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="964"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1073"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="985"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1176"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1230"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1309"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1362"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE38625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1435" mass="157653" checksum="DF90D10950EC3FF4" modified="2010-05-18" version="1">MAPSTSFGAHPTNRPSHYRTPSPPRHAIEPLSPRLSFAAAASPAALPRRDRLGKPGASGSGRGGDGSVPSVDEAWRHSSNSHRGVEPLEHHHQHPAPPPPPPPQQQQQQQQPHPEYQHHNHQQNQQQSPGRPGGHARSRSTIDTLATIALATSPTFSPLAYDGPDEPIISPLGHQGAAPDIDERPSKRAKSEKAHSPGWQRLGDRPATSHVSTLDSMKTDAELLLNFARPTNSPHYSPHITPLSRVTTENSTHSWNTDLWRGPASAVAAYDHGDVTRDRGVPAWPGMAGSANGVPPVRLRSQSDGAAALSRPAMNGLLPDSPLYPSAMGVALEDDPEEEEKPARKKKKYKNIPTPSAPPTPSWGQETPVIPFSKPSQDKEPTKSKPRTKQKAAEDGSSAGQTNCAACNRDRAPAGVGGDDAEVTWVNCDGCDQWFHIVCCGFKSDHEIRTVDKFICTKCRPVHGPTTFVRKSTRPRTAIDYAGLNQGFVKPPSEEHENIHLAAIKQGTITFLPDHFARMPPDLVTASYFERGAGMIEPIVIPAHMNSRAGFDFHEATTEEEFDATIPEDNGYEEAIDCGQDLLDMVIPKGLTVKAVGEIYGPEEKIEVIDVKSQQGEEKKWTMQRWMDYYYDTSSTKMVKNVISLEVSQSPVGRLLRRPRVVRELDLQDSVWPPEQQALGDYPKVQFYCLMSVADCYTDFHIDFGGSSVYYHILKGKKTFFFIPPKEKHLKKYDEWCNSPAQDTTFLGTESKECYRVDLSEGDTMLIPSGWIHAVWTPEDSLVIGGNFLTRMNYAMQLKITKMEKDAKVPRKFRYPFFQKIMWLTVLKYLADDPIPPRLRDAFAQDENYQFHRENPVYHPEAEEFAASQEPGSDYYDAKFYSQSEIDGLPELAKYILRTALIAGGYKVDGVTKETRNAVSRSIPKGQGDPVDIAQKFGVWVAWKRGNELAPQWTRPGAIVMDVKVDMSDKRRSTRPRKQSERAMTGSQKSRPSLNSTQKPSDQGSQPAVSTPLRDVSASSSSGTPAGEIRRPSVAENKGLEANPRQTPKAASLGPKRIACDPCRKRRIKCRHKEGGGLDASSDQETAKDPSLGANGGDTTLTTSRPDDSIDRANGDSLPYRNGIPHQASISGPNPPDAGGNGLRRPQETSPGSSSSSKKGRIKACEECRKSKRRCIHDEAGRVDPVKIQEQPKTKRSRPEDEKSSPPKKQKRGENKSPRSTEDTSSSTKNDTDSAQDSKIDSSKDKAHVLKSNFPRDSPLYSSPPAGNSEAEAPSEHPIAPESMLPIGSLVSPPTSLVDDIDGVPGSLDGEKGKAVEGDRNTDKPLSIHTPTSISYHQSRYPSLNTKVADGQKQRSSKDRSSASGLSPSSPVRSKTSSRPGSSHRANDGHGPSSRRAHDRASFAEADVDPDSIKLIRQLQEEDFGLRRRPAKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHM6</accession>
    <name>D4DHM6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019278.1">
        <property type="nucleotide sequence ID" value="XM_003019232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHM6"/>
    <dbReference type="GeneID" id="9577519"/>
    <dbReference type="KEGG" id="tve:TRV_06682"/>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE38633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="56642" checksum="89329DE1EFBF26BB" modified="2010-05-18" version="1">MAPSQHSRRRPGFFSWSQTAVAAAVAIITVMAVLPQAQASESVGEQQRRDIPAGKRNVILMVSDGMGPQSVDMARAFRKWQTGNEHVLYLDDHLIGQSRTRSSNSPITDSAAGATAFSCGKKTYNGAIAVLPDHTPCGTVLEGAKAAGYRTGLVATTRITDATPAVFAAHANSRSYEDLIAEQEIGEHHPLGRQLDLLLGGGRCHFLPGSNGGCRDDNKDIIKLAKSKGFSYVGDRRGFDGLKGGAAAKLPLLGLFADDNIPFEIDRRYQNNVYPSLEEMTRTALKALSDATRDSNQGFFIMIEGSRIDHAGHGNDPAAQVHEVVAFDRAFAAVLEFLEQDSTPGILISTSDHETGGLSAGRARPNILNNASHSAEYLGEVLENHGGDHDVARQLVEEGLGIHDASDREIDSVVRNGEEGFAELISQRAQVGWSTGGHTAVNVNIYASSREDASALVGTHENTEIGNFLAKYLRVDLNAITKRLEGIRTTPRRRALSDSSWMGKPLSAEDLEELKHRHGNYTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHP1</accession>
    <name>D4DHP1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019293.1">
        <property type="nucleotide sequence ID" value="XM_003019247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHP1"/>
    <dbReference type="GeneID" id="9577615"/>
    <dbReference type="KEGG" id="tve:TRV_06697"/>
    <dbReference type="HOGENOM" id="CLU_764993_0_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF51">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN BAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="376" mass="42775" checksum="E4CD5AB9C388ADF5" modified="2010-05-18" version="1">MMKVRARRLWTKEEDALLRKAVNESMARGGDINWHRIASNIPDRNNKDCRKRWVYILAPSLNKGAWNKTEDEKLLQGIQKHGFRWALVSQVVGSRQPDQINNDRWSLLEDEILREAVEIYGRRWTEIVDRYFPNRTPIAAKNRFVVLSHINFVARSNDVSFPNMVPVVRYTQRFGSNKTDGTVPKPSGSATKKKSPMVKPTTSPVTRVEETRAPCQTIMPKLLWHVPDHTQSQQARLPAPPKVTVPEVWPTNDTQSPLTAVPSYQQVPSLTSSPSPVPIPHTPLIDPIRPCEPTSMSPYSYYTVTSPQAEMCTPSFVDPPLNGNFGYEPWVSNDMISLLHNGVVGYPDMGYSTNVPTMERRYDQIRFSDHTTLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHR6</accession>
    <name>D4DHR6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000384">
        <property type="protein sequence ID" value="EFE38615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019260.1">
        <property type="nucleotide sequence ID" value="XM_003019214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHR6"/>
    <dbReference type="GeneID" id="9577498"/>
    <dbReference type="KEGG" id="tve:TRV_06723"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_1"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="42859" checksum="5F37E1F8C2C3AD2E" modified="2010-05-18" version="1">MAKIKTIEHFRVLPRWLFVKITDEQGGYGWGESTLEGHSESVEGALNALSRQIQGYEADDIEHIWQTAWRQGFYRGGPVFMSALSGIDIALWDLKARRLGIPIYQLLGGKVRNKISVYAWIGGDRPADVEAAGQSRLAQGFKAIKMNATEDINWLDSPRTLEASVERLKTVKDLGLDAALDFHGRLHKPMAKQLAKMVEPYQPLFIEEPLLSEHPEGIKQLSSQTATPIALGERLYSRWDVKRFLEDASVDILQPDISHCGGISELRRIAAMAETYDVAIAPHCPLGPIALAASMQVDLSTPNFVIQEMSLGIHYNTTESGEEYDITNYIKDTSVFDVKDGYVKALDGPGLGIEVDEEEVRRVSKGTKPWVTTGFFGPDGSIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHR7</accession>
    <name>D4DHR7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000384">
        <property type="protein sequence ID" value="EFE38616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019261.1">
        <property type="nucleotide sequence ID" value="XM_003019215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHR7"/>
    <dbReference type="GeneID" id="9577499"/>
    <dbReference type="KEGG" id="tve:TRV_06724"/>
    <dbReference type="HOGENOM" id="CLU_399344_0_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="690" mass="74751" checksum="FCC5B4E61FD88EF7" modified="2010-05-18" version="1" fragment="single">MTAMKQLIPSAACVAARQRASSPPGLTACKSAILTAARGSFSGSAVLVLSNLSAGEAGSSLSSPSSSSSSSSSPPLLCLCPVPSDSSLSSSPQSIAVVCVSSVSTDSADCRWPSEAVEEEKQTRTSFDPARAEFLAQPVVLLPPQRRQRQRQQHPTQRLHVFSWRSHLEASASPCRRLAVTAAPAAAVMAMTTPHLPIFFFFFFFFIIFPPRQLPPAYYLQQLESFASPVPDLAATLMSNPEDEIHSENVHFLRSRRRSSTELSPSRARTRRRQLGGGGGGGGGGVGVGAGAGMADSPHDSVDFGGDQYMPRSHQQYTSGHGQRIPIIRRRGAMNISHGPAYEGPPQQSNRIYSWAPTQDEEGGLYVRTDPLHPRDEIWFDRSASSSSRDEDGSLWSHLPRELRGTAQLASESPPEEQEGGRAVGAPNMPLARDNPALVTAAILQSVRRNHRYSPRVRTPQNQMQDDDGRDRTINASTNGYSSYNNNSSTSNNNNNNNDFATPFSFSPQGRRSSPRLSPPARIDTSRNSDIRRMYLKDPSIDRLREAIQYLDRVRFSNSYEESLSTAAAGGFVQFEYFLRNEDDFILDTGSIAGPGYCSWLSPGTVFSGQQQATASTAMLPHRLLGTTRPSTESNAASGAGSRISVYTSSGRSYWASNIMGNSNSNGSNNNSSSSSQDPEPAKTESWPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIH6</accession>
    <name>D4DIH6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018973.1">
        <property type="nucleotide sequence ID" value="XM_003018927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582134"/>
    <dbReference type="KEGG" id="tve:TRV_06985"/>
    <dbReference type="HOGENOM" id="CLU_001147_0_0_1"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="232"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="854"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1322"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1630"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1669"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1474"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1496"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1590"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1688"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1723"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1797" mass="192847" checksum="420F13DEF62CBEBC" modified="2010-05-18" version="1">MSDDSSSKPSAEPDVAAALPDSQECSAPTETVPSRPPTGSDPSDDHQPSESQEVSQGTETSTSLDQPTGVLGLGDTAVNTENSELLTLLESNTQTPQQDKLEAPSVHVDDTEYVPQPTNLQVSDPNVPEVTLTEDTTSSGPNDSIQPITQSSDEQTTLLSRSNTAELLARDDIVSRTNSFPTVNSTNEPDHTTTSAPQVIESAESQHDPNNDTPNIPPTESNVNSGSTNAAPLWNDEVDNEAEGEDFFNQVSTQTKPIYIPPEFAESRFEEGLPLVDSGEQSDDQQAAQPKQQSALDSVFSEDISTDEAGFFSSHMSQAAEQSEAPPTLHRKQTSQVLDSLRMDDAFRGDESPVEPPRIPCEQMSTSEAVDGHQTSKDDETTPENLDENELAERWKAALDDDLLDDELLDDDLLDNDNAAQQEDEKPPAPPPSQRYAPNTSAYLPQSRPAPPPINPYAPHQPSSSSMMEGIAPALYGEHAQPISPVSASAESFSNQPKAGYKSPYDLPDDLQPKRRIAPRSASNISQPYQPTPDSRPSSSYSAAPLQTASPVAPTNPYAPQPQPQSQKPAGPGNFFEELPIAPRSRPSTRGRYAPPPAEAGRQAPAGSQMMTPTPQQHNEPQPQGQYGLQAPPRMDPYANVIAPVGPVATKPATQYSSRPTGKPAASGRYSPAPPLSSSAPSHSYMPNHAGITLPFQPRTSSPLAQHDSSHVRPQVHPETPREGSFGSQESAQHLSPPAAHNDFGQRNYAPMANAISSPPSSMPPPSAPVRMSPPRRSQTQSPGKRIYSQGHPSIIQDNAQRPASAHAPSGPPPASHFPLARAMTVDPHPAPAIDFIAPADSHSLDPLERWKGAPIIKFGFGGSLITSFPKRVPLYSTGQLAPRMKPVPGEVKLRSFNDAIPESVMPAKFPGPLKSKSKKKEVITWLSNMISSFEHEDPQGLVSLTQGEYQAKVEKIMLWKVLRTLVEHDGILRGAPDAEKSLRSILSPITPQNDQGAPTMGSTNTLYGKEEPANVSLDAIQHNLLLGEREKAIWDAVDHRLWGHAMLLSSTLNPSIWKQVVQEFIRREVRSVGENTQSLAALYEVLAGNFEESADELVPLSARAGLQMVNTRTGQGPTGNALDGLNKWQETLSLILSNSSAQDDQAILALGRLLSSYGRVEAAHICFLIARSSTNPIFGSLQDPNAYIVLIGADHKRYPFTFMADSTACLLTEVYEFATSVLTATPLHVLPHLQAFKLQHAMTLAETGHRSEAQQYCEAIGALLKTATKLSPHYNQRFFIELEELSNRLRQSPGDSTSSWMSKPSMEKVSGSMWAKFNSFVAGDDSSPDSSDPSKPHEDQGPFANIVGTPPVTHSPGGPESFGSYFPTHQQQPVAIPASNSRYAPNNQYAPFSSPDQLRGRRSLDSQRSPSRGAAARSYSQRRHSQDPSTGYENSYAPLAAGNPYSPSPVAPQPTTHSTPLPAHSPLAPVEEASSSLAPSTTSEQAPGMGVSAPRPSSFQPAYQSVNATYSPPTQESQGGYEPPSEGGYQPPSYEPPSYEPPMNEPESPESEEAEEKKPKPRKSFMDDDDDDSYTGKGAAAAAPTNGVETDRGRREREAAELVRKAAEEDEQLICVLAKRPPPDAKKGWFTGWFGKRDPSASGGPIRAKLGEQSSFYFDEDLKRWVNKKDPNSATSSTSALPPPPKGSAAGSRSASAEQRPPTSASVASAPDAVPIPLARQLSAQGGPNSPYGSAPPPSSLGVPGGTPPLTPSSRPGTALSHASSIDDLLSAPTSKKGGTLKGRKKGRYVDVMAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DII9</accession>
    <name>D4DII9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CLPTM1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018986.1">
        <property type="nucleotide sequence ID" value="XM_003018940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DII9"/>
    <dbReference type="GeneID" id="9582310"/>
    <dbReference type="KEGG" id="tve:TRV_06999"/>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055550" description="CLPTM1 domain protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72016" checksum="D683FCB7EB3FB8B0" modified="2010-05-18" version="1">MLKGFVMLVVSQFVLTKAMNYWNAPNGAGGAAAVKNSFPKFSERPDQDTITNATYFPVKAVPMWEPDSKLDIAIHVTPSTTFPLPKDSKVLDEKGFDTADTKELREISTTLFIPKAVQNNETLWAHFFVALSGHPQYSNEEGYSSDTAYNFSHPVNQYLPKKKAKKLRNLLDAANETEVVEEEPKVVKIGSFYHPNLTVSLVPDQGAISFQSTHPSIRRFLQLERTGARDGSGEVGWYYPTFFFNRFWQLRNHMTELNSTVNEVPLRITLNTVKQWQFAIMSSIEDDSKQKQHQAAFGGPIPPTSGDGSEVEMIKEVLLDTNIYLLITTGVVGVLHTIFEFLAFKNDISHWRKKKDVVGTSVRTIIANVFMQLIIFLYLLDNNENTSWMILGGQGFGIIVEAWKITKSANVRIRPPPANSYLSFLPYIIVLEDKHKLSETEKKTQEYDEIAFKWLYIAAVPLLIGYAIYSLLYETHKSWYSYIIETLVGSVYAYGFLMMVPSLYINYRLKSVAHMPGKALTYKFLNTFIDDLFAFTIKMPTLHRLATLRDDVIFFIWLYQSWKYKVDYTRVNEFGQGGDDDEEEEKVQATRKSEENNSGGDSKTVEPSVPAVKAGESEASSSAKASSKGSMRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIR0</accession>
    <name>D4DIR0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000410">
        <property type="protein sequence ID" value="EFE38257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018902.1">
        <property type="nucleotide sequence ID" value="XM_003018856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIR0"/>
    <dbReference type="GeneID" id="9582066"/>
    <dbReference type="KEGG" id="tve:TRV_07070"/>
    <dbReference type="HOGENOM" id="CLU_117263_2_0_1"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13475" checksum="1A62B9A7510A11BF" modified="2010-05-18" version="1">MATQQPTSRALHARINADITQLLQRFENIMAAATVDNPSRTSSAIESYQLDVESTALIRAAEDILSLTRTLKETWLFGKLETLGEDERDIQRREQLEKDVEAVRDMIQQRTQAESEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU2</accession>
    <name>D4DIU2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018877.1">
        <property type="nucleotide sequence ID" value="XM_003018831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIU2"/>
    <dbReference type="GeneID" id="9580049"/>
    <dbReference type="KEGG" id="tve:TRV_07103"/>
    <dbReference type="HOGENOM" id="CLU_014183_2_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056301" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="491"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="750" mass="80191" checksum="3C694FA4517F2183" modified="2010-05-18" version="1">MERVTSKLLFFLAIFHSFISLSGAVPSPWLAALRSQYDTNRTTMPSHGTTVNNSNVTVDFVSALSIADSVSSKLVRLSDIPAIALPPNISNYDAYAQLASLMPPLPAGTVGHDTAEVLAAIKASIKAVPSNYTARTGLTERQPGLRVMFVGDSMTQGKEGDWTWRYRMWQWFRDQGIAATFVGPYTGTAQPAEPQAPSPPRLYGTKEPMGAVKASGGYAPGASPEFDSHHFAVWGRAAAVDKGLIREVVAAHPPDLMLLMLGFNDLGWFYSDAAGTLDSMHTIINNARDANPRLKFAVANVPQRSFIGGRDDLPVSTAIYNSLLRAALPKWSTKQSPIHLVELQENYDCEPSACAAGYDGLHPNAQGEFQIARAFTLTLVNDFKIGSSALEVPSDIPSRSLPVPSNFKVVSSPGGVTATWDAVYGAHSYDVESRISGVTQFSAGSVPANRWDAHWTQDGWVYDVRVRASAGDTIKSDWTAVLSAKSTPKTAPAPVNVLVGATSTGFDVSWDPPTGPYTDSITQYEILYWDKDEECAFITSASFLSSPARIKDLVPGHRYLVAPITWNAAGGGFPKIVNSVMVGRGTPPPPSSLEIYANDPTTIELTWAASPNAAGYRLWSRNVNKPGSISQAQNNTVEMTCSDQYLLFPGTWNYEWCVSAYNGNAESAKGKCVLAPSPGPSPAQKRCPPPPEWCPAGSGPKFPGGGSGADPGLSVPMASAKAPTAKWVFALGFFAFPLAAAGLIALMVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIV2</accession>
    <name>D4DIV2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018845.1">
        <property type="nucleotide sequence ID" value="XM_003018799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIV2"/>
    <dbReference type="GeneID" id="9581489"/>
    <dbReference type="KEGG" id="tve:TRV_07113"/>
    <dbReference type="HOGENOM" id="CLU_005461_1_1_1"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="102805" checksum="0A53F20935E37353" modified="2010-05-18" version="1">MDPDRLVKVEDMEIEEDTYLDKPVVEEKYTRVRKKKPFRPVRGTISVLLRLFVWYSIFIALFRCPSSLSELDDESPRVCEPYIIAKTRLEPYISPYYHKYAAEHVEHIKPYAQSAYKAAEKVYIPTAQFSKNIYQGHVSTYVEQAMELAKSQWNQKVSPHTDPLQAQVVDYYTTSISPRIQSAQSIVIPYFWVAAEYSVHVNNNYVVPAYIHARPVIHRVCATIYDFVVTTIAPYIQEAWSAIVVFLNGTVRPHIRTLYSENVEPQLVKIGEKLASYREGRTIQQVNLETASSVVHEYTATKSSTRSSVESKDTRVSSVAPPATTKLTSAQQTALAREKISTDLKAWKERTTSLASKGLEHVRTQVRQVVEDIARQEKPSGEDILARLESVASEQLYTLAQDLYSIIQAIPEEYTQEDEDKAQDAFLQRLRESSHAIRGMAHSLRLWFNKYQETLTHAVTKTINITLDVLENARELGLQEIGMRWTAIDGVTYTDWASYYELKSDLGEWKDDIRQAGLQHDSFVLAKDDGENIVARGMDIALDAARQLAEIRSIGKLKIEAGDTTRQLNVDHINDEMIAKRKKYLITSVTSTSTVEPTPPEISDASEMFISNETEASEPSESPVAEIPVAESLEAEVETPPGEEYVGEQPKSALLEETIPSDEALEPQPTPEAPVILEETATAVIPEGSSPGFTSMIEEPVSPDPANFEKSDQDEVIDVIEQEHGQLPVDHETPDDTIQADETVSLPSSLTSSTPETKAEAPAFVTQVVEDATPNEPEDTLSQTTEHTQHTPSIPLGEPVDVHEMVGSATEKIISLVDSAKAGLSETPLPKNEASTLMQDASTKLGDIVSSVQSSISSLEATPPSESSPPEQRREHIKDEISRLTAALEAAQAALLELYRSDEPGQPQESTSDETAYEYNEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJD5</accession>
    <name>D4DJD5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000435">
        <property type="protein sequence ID" value="EFE38036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018681.1">
        <property type="nucleotide sequence ID" value="XM_003018635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJD5"/>
    <dbReference type="GeneID" id="9580836"/>
    <dbReference type="KEGG" id="tve:TRV_07301"/>
    <dbReference type="HOGENOM" id="CLU_890159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="313" mass="35504" checksum="29AD06BBA618203C" modified="2010-05-18" version="1" fragment="single">MEEKGGGRGWMSGGLFAAALQKNFSMFLMAETRRLFAVELPGRRRLACLPGFRSSNKKKKKKRRRRRKKRRATRMFEDEGRPLEEKKKRPAKAARESGLFGPVVLLVCSCRRFCDAESSGSFPPWLSHKPSVGSSRKDGEEKASIERLKKRTGKSQSIIIFYEEEKWIGGWVGRLVRRSGAGDQARDLTFPERRLRDDDAPEPGDRPRLQQAAIFLRAEQQAEMPASFRCNELTSYTNGKFCVASPDLRLIDAGSMQSGGRLARLRLPLCARVTSVHSPDTRRIMHWRLVDPINSVHSPLLVFLPRYGNLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF4</accession>
    <name>D4DJF4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018632.1">
        <property type="nucleotide sequence ID" value="XM_003018586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF4"/>
    <dbReference type="GeneID" id="9580783"/>
    <dbReference type="KEGG" id="tve:TRV_07320"/>
    <dbReference type="HOGENOM" id="CLU_1644949_0_0_1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="18106" checksum="FE652983D242054A" modified="2010-05-18" version="1">MAHLLMNEKFDTSTFLAGLAFIENIEDFISFSMSIGSIGRKNIVSLELHWESKAGIFSTVRSTRVKEDHKSPQLVAVSPCVKVRGTPRRILELENITSPVDDGMLNAVHLESFKTHPRNLELCSLKVERVHLNGFESSLDRNQVSIEMSLSNGAKELWNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJP5</accession>
    <name>D4DJP5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018568.1">
        <property type="nucleotide sequence ID" value="XM_003018522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJP5"/>
    <dbReference type="GeneID" id="9584497"/>
    <dbReference type="KEGG" id="tve:TRV_07413"/>
    <dbReference type="HOGENOM" id="CLU_2607752_0_0_1"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="8496" checksum="4C348A463312ACDE" modified="2010-05-18" version="1">MAFPKNTPPDSLIRRDDGRRFWEGKDGNEDEMIGTGEAQPGMSEVDLQGSREFLAKLGIGTGPGLRTLIDALEGGAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJS3</accession>
    <name>D4DJS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000444">
        <property type="protein sequence ID" value="EFE37895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018540.1">
        <property type="nucleotide sequence ID" value="XM_003018494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584469"/>
    <dbReference type="KEGG" id="tve:TRV_07441"/>
    <dbReference type="HOGENOM" id="CLU_001585_1_0_1"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="737"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1517" mass="161976" checksum="D050464A16B2C7C3" modified="2010-05-18" version="1">MSSPLPSTFASAAAGNTQDPAPGSRRDAMNSGEWSRNRMNGATQTFRRPSVATNPSHNRENAQQAQSNTSNSSSAAYIPPHLSSNYPSARSGNDNTYSKEQLLNLYKNHRGSKDWGKSITGYFMGDWDPRSERPSTNGSWGKQDDSKDNTTANPEVCWDHKGQSEPLGLLDMNDEEKELFSTSVNSPLKPPPQNSNKDGSSSVGTIGRKSSISHGHMNSFNSTSPASARNVPRRRGTGDSGNPMSPTNSRFFRDEPNTATPPPAILRRKTDIKDSSGDSKWEDKDKSFAERDSSFDISSPFGSLKRSTTNPVGAVGSNSPWSSNQGSAFGSMGVGAFGNFALGNAGSQGGTDKKPGFGSVRSESRFKNLLSKSSSEDIASSGNNKDKSSSGTGLDRLPEAEDDAPRDSAEEALRNRPSRSETNPFDERRSGSAALGGQEIGGIDQFGLSSFGMPGGTSALRDLVASSQPPSHAHHEPMSPTHTNPYQSPRGDRTADNGVVGTGDADNEGSDIQQHARLPNIGDLRDDSAHGSFGSMSRSGMISDIPAADRSQTSSVGANRGFPGLGGLGGLGSLGNSGGWPTTSATGTPTRERTAFGFGDPIFGPMSELQSPSNSALGGGGLFGSQTSLSNMGGGPRPSKLGSLFPPAMQEQMRNEQSHSKDEPGKPQDPFMSLENPVSLPHPSTTTSHTPTVTAGGTITIPPGPGLLDNGNGNQYGASASNQLPPAQQRQMVMPDRMRWIYRDPQGNTQGPWSGLEMHDWFKAGFFTAELQVKKLEDAEYEPLAQLVRRIGNSREPFLVPQIGVPHGPPMNQPGPWGNSSQSQTGAVQPPFANSFPSFGTTLTAEQQNALERRKQEEQYLMARQKEHLAQQQALMKMQQIQGPAHPINPQLQHHSSAHSLQSQPSFGSITSPAAFQPIPMQAPIQPPHSVPAFFEGPMRQNTGPPGPQGGAPDFGTGQDELPALLDRMNVNRGAGQFGYNNTGAFPPTPQDPQAQAHNQAVTTMLQDRSRLQQEQENFNKAHPESIFDQQAREERVRQFHALRIADEDIPVRRTEEPANHREPSQEQQRPLQERSPASKDQTPFQQNNEQELTLTQQVQNAASAQRLQQQQQQQLASSEVESPWAKVDTGLPQPFPPPPSQSPLPAPAAQRNRQHVADNLAAETRSQTQTPNEVHATSIAPWAKEHTEPSKGPSLREIQEAEARKVARLEELAVSARRALAEQERANPPPAPAPGLPSTANWARSGNANSSADTSAWSKPAGGKNAGVPANTAPKKTLAQIQKEEEARKQRAAAAAAAASAANSLGTPAGKRYAELASKMTAQQPTAAASSGAWTTVGASGKAKAAPVSTAVNARNVPGLTPSPTPATKPKTIMTRNVSMGNSAATTANRPTEELAKWAKNALEKGLNSSINVDDFVQQLLFLPAESEIISDSVYANSQTLDGRRFAEEFIRRRKLADKGIIDTASSGAFGSPAESKNSSDGWNEVAKKGNAAASREDQATSNASFKVVSKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJV3</accession>
    <name>D4DJV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_07471</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018525.1">
        <property type="nucleotide sequence ID" value="XM_003018479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJV3"/>
    <dbReference type="GeneID" id="9584454"/>
    <dbReference type="KEGG" id="tve:TRV_07471"/>
    <dbReference type="HOGENOM" id="CLU_020639_1_0_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="21">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="421" mass="46634" checksum="86A2F35BD1A3C11E" modified="2010-05-18" version="1">MEKQLRAADPDEEQRLERIRRMPSLDQCYNLMDFESVARRVMKKTAWGYYSSGCEDEMTMRENHTAFHKIWFRPRILVDVEKVCTRTTMLGTPVSAPFYVTATALGKLGHPDGEVCLTRASATHDVVQMIPTLASCSFDEIVDAKTDKQTQWLQLYVNKDRAITRRIVEHAEARGCKGLFITVDAPQLGRREKDMRSKFADQGSSVQATTASSSSAAAVDRSQGAARAISSFIDPSLSWKDLPYFRSITKMPIALKGVQRVDDVLRAVEAGIDAVVLSNHGGRQLEYAPSAIELLADVMPALRVRGWDRKIEVYIDGGVRRATDILKAVCLGAKGVGIGRPFLYAMSAYGTEGVEKAMQLLKDEMEMNMRLLGCTSIDQLGPDLLDTRGLSVHTVSGPIDNLSHSVYDPMSLPADRPVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK54</accession>
    <name>D4DK54_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT and Ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018421.1">
        <property type="nucleotide sequence ID" value="XM_003018375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK54"/>
    <dbReference type="GeneID" id="9584349"/>
    <dbReference type="KEGG" id="tve:TRV_07575"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OrthoDB" id="4184734at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="731"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="830"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="931" mass="103263" checksum="E104D3718565FAC9" modified="2010-05-18" version="1">MEAAASAIGLIQVTTHVLHLTVKFYFEVRDARKEIKSLEGEISDLQGTLRKIVDLAEDTSDPEAIKRLPAFALLLGEDGALARCQAELLELAGKLEKAGGAGSGKDETLLQKKNPMRQFGVRALKWPFTSKEIKSSIAVLERCKASFNLALTADQTKLTLDTNRLVVELGKDITASRNEQQKGEYRSKIIQWLSAVEQGITWSNHEDARKKHSQGTGEWALELQAFKEWKSTGPAILWMHGKPGSGKTVLSSSVIEHLQAEYDSEANTLLSYFYFDFGTPAKQSATNCLRYLLSRLLTKAPEVPQELRDLYVKKCNFGSETPALSDLIFIFKLFAESEAIENIFITIDALDECPLDNRQELLDFLTTISSWTPSNLHVFLTSRPESDIREALSPISIVTAVSVGGSSVTQDITYHIQSQLSSDPALKKLPAKLKSQIQSKLIADADGIELKRCKTKALLIKTLESLPKTLDGTYERILQSIPTNYQDYARRALWWLVEARRPLSAEEVAEAAILDADEDTPFDPEGRFFNPQDDILEILGSLVSVAEREHEVTDVNDESNSRATATTVNETFNELRLSHFSVKEYLISTHPLNCQNPLVAQFYVDKSLVSSFILRSCLLYISHYIGSDYRAGARDDVDEFPLLLYVCEFWFAYAGLPLDNKSSGLLNDFFASETQVQAWLLVHTPNQPRKDLFQPPDEPGQALHHACYLGLTGTAKYLIENGATVDCTTESGVTPLIRAAERGHVDIIDLLLNFDSNVDHSTRGGRTPLQVACSRGHIKVVERLLISKADVESKDVDLWTPLYWAAEGRHEDIVSLLLKQGADPNARTMSGGTALHQVCGRDYDEIARHLLDSGAEVDVATSWGRTPLHQAAAGGSLEVVKLLLAYGADPNVLDRSYSSPVSLAEENLHHEIVDVLRPLTNLKDPLDSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK9</accession>
    <name>D4DKK9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018281.1">
        <property type="nucleotide sequence ID" value="XM_003018235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK9"/>
    <dbReference type="GeneID" id="9579977"/>
    <dbReference type="KEGG" id="tve:TRV_07731"/>
    <dbReference type="HOGENOM" id="CLU_068297_0_1_1"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="30536" checksum="DB2F363EA8B5DDD2" modified="2010-05-18" version="1">MNTPIRTAVLGGRLSNAWSPLATGGASGPLSMTGYQHQPCRRSAPQSSPLKQHPIRASSYATACKSPMHPANSFSNTCRGNYSSSSANSPTLQLITRNSQPCLVSRRNSSTSTQAASSSSHPTSTSNTPVKLDWNTFFQLRASRRKYSLISSVLAAFTTTAAGGQILATQNLESLGAQIMGFDPLIVLGLATAASGALGWLAGPFLGNGLWGLVYRKYKSAVAIKEKEFYDRIKRFRVDPSANSFANPVPDYYGEKIGSVQGYRQWLKDQRAYNRKKRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKP7</accession>
    <name>D4DKP7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000478">
        <property type="protein sequence ID" value="EFE37579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018224.1">
        <property type="nucleotide sequence ID" value="XM_003018178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKP7"/>
    <dbReference type="GeneID" id="9579594"/>
    <dbReference type="KEGG" id="tve:TRV_07770"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="69"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="571" mass="62522" checksum="BD5223BF1D16A1B9" modified="2010-05-18" version="1">MEMLEKKEPGLAMDNGGSGKENDVVSDSTLETSPALGFWTRMGCTPESFKQRTLEDRHNQFNQTLKSRHLHMIAIGGSIGAGLFVGSGSALRAGGPGALVIDFAIAGMMMFNVVHALGELAVLYPISGGFYTYSARFIDPSWGFAMGWNYIFQWAIILPLELTVAALTIGYWRVNVSVAVWITVFIVGIIIINLFGVLGYGEGEFWASSLKLVSIIIFMIIALICVLGGGPSYGKYNEYWGARLWQDPGAFANGFKGVCAVFVTAAFSFSGTELVGLAAAESKTPLKSLPSAVKQVFWRITLFYILSLVFVGLLVPYTEKRLLGSGSLIDVAASPMVIIAKDAGLTGFDSFLNVVILVSVLSIGNSGVYGGSRTLTALAEQGYAPKMFRYVDRAGRPLVSTVAMILVSFLAYINITASGEEIFGWLLALSGLASLFTWGSICYSHIRFRAAWKLQGHSLDEIPFKAAFGVWGSWFGLIMVGLVFIAQFYTAVWPLGGGVNNAKGFFKTYLAVPVVILFWLCAHIWKGKSWLKLRDVDVDAGRREIDWEAHNHVMEKRRTASPWMRIVYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL44</accession>
    <name>D4DL44_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018082.1">
        <property type="nucleotide sequence ID" value="XM_003018036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL44"/>
    <dbReference type="GeneID" id="9579291"/>
    <dbReference type="KEGG" id="tve:TRV_07918"/>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="464" mass="51517" checksum="43F82B7796F4BC5F" modified="2010-05-18" version="1">MSAPQGAGEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQISRAAKMLAEEFGTASNIKSRVNRLSVLSAITSTQQRLKLYTRVPPNGLVVYCGEIITSEGKERKINIDFEPFKPINTSLYLCDNKFHTEALSELLESDQKFGFIIMDGNGALFGTLSGNTRDVVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITADKVNVAGLILAGSADFKNDLNQSDLFDNRLQSKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDSGRVCYGVEDTLKALELGAAETLIVFENLDITRWVLRPSSGSDIVLHTTKAQEANREQFMDKETGQEMEIVDQGSLLEWLAENYKDFGATLEFVSDKSGEGNQFVKGFGGIGAMLRYKVNFEQLADVEEDDDEFYDAVQICAPHHLASSKLLKGPSKLRNVATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL63</accession>
    <name>D4DL63_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018049.1">
        <property type="nucleotide sequence ID" value="XM_003018003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL63"/>
    <dbReference type="GeneID" id="9579173"/>
    <dbReference type="KEGG" id="tve:TRV_07937"/>
    <dbReference type="HOGENOM" id="CLU_037790_1_0_1"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="38732" checksum="8FA363C5F5845C9C" modified="2010-05-18" version="1">MIRHSTHSSRRFDEYYRCYPVAMLPGPERENVNHGGKVIMPPSALDKLTRLHITYPMLFELHNGAKQQMTHAGVLEFIAEEGKIYLPFWIKSTDLPPGSKIKLQAQSTSFLDISDPKAVLENAFRNFSCLTKGDIFTFSYNDQIYEMAVLETKPETSQNAISVLETDLEVDFAPPVGYEEPKRLSGTSTPASGVAGSLPAGGTLHSHGTMAQSINYAAIAPGSNDAARAANAASSNFHGSGQRLNMKKGSKSSTPKSATPASGKSSNPPPAPPTRRSNGPQPLRLPPGKLFFGYAVTPVKKKDSSDESPESGAQPKFLGTGQTLRAKKKGSGLAGQATPASGSDTEKKDKGRTLGGKSSRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL76</accession>
    <name>D4DL76_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018062.1">
        <property type="nucleotide sequence ID" value="XM_003018016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL76"/>
    <dbReference type="GeneID" id="9579190"/>
    <dbReference type="KEGG" id="tve:TRV_07950"/>
    <dbReference type="HOGENOM" id="CLU_029265_0_0_1"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="483" mass="52720" checksum="6301C842CC67B6BC" modified="2010-05-18" version="1">MSPQSSRVMSPDAAGPSSSPPVLPEGWLAQWDGRQQRWYYVQPVTRKSQWEIPTEPFIASTSSTPHSAASPGPYPSPLTMSATSPESEATRELMEVRNAKWNGNGNFAATQQLSPQSTSPRSQRTPVAGDAVPHPRSSAQTTPVHAIADISALASQDEMMVQHNSVCFKLLIFCSSNRTSELIGFFKQPNHSRVGSNTPQQPMSLPGQVQGFHTTSGSPANQHQAQHFPPHPQSYNDSHMQNSGLPLGQPPHVNSIPMNPSPQGQLYGAQMHDSNARPFCGPQQPADPRYTNQAIPVTPGKFPPRVSPVQTQRHQEHGITLLNQDPNAPPVFPLSHREAQRKRQSERQESFAKYQAGPAGQPYPPRGPPAGNYDHRYREPESLPRNMPPPPPGFGSNPIYDPLIDQTRPVYHESIQGPPGGPYGSSRQLGSPGNGPAWQQQPPPPPPQQYGGYQPGMPPRADYVPPPQQHYGDVGGYPGNWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLA9</accession>
    <name>D4DLA9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000500">
        <property type="protein sequence ID" value="EFE37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018011.1">
        <property type="nucleotide sequence ID" value="XM_003017965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLA9"/>
    <dbReference type="GeneID" id="9579137"/>
    <dbReference type="KEGG" id="tve:TRV_07983"/>
    <dbReference type="HOGENOM" id="CLU_1726754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="152" mass="16859" checksum="1F3BE148FC454C56" modified="2010-05-18" version="1" fragment="single">MVVFIDHSLEDASLSEPVGGFFEAGKIPPPPLTKDCQFMLAASLSQLRTGDCTRADMVDKTGLERDRDPSCLNGLISMALSCYPYAKTSHLLLLLLLLLLLLLLRMKYVDSLYIFPPFLNAVVSSNFLSKIVDHMHCLSLRSSLQDSDHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLB8</accession>
    <name>D4DLB8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">TRV_07992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017988.1">
        <property type="nucleotide sequence ID" value="XM_003017942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLB8"/>
    <dbReference type="GeneID" id="9579116"/>
    <dbReference type="KEGG" id="tve:TRV_07992"/>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="730"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="754"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="785"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="827" mass="93108" checksum="EE2428624B07CAE8" modified="2010-05-18" version="1">MTSNGHFSSVGDVDGGDYQHGVQVVDGDKEFNPNLSKYLIHENVTPAGFNYHLISVFGSQSTGKSTLLNTLFKTDFSVMSETERRQTTKGIWLSKNKRTASNEKEKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFENTLMQDLQRIWTSLSKPEGTENSTIEDYFDFAFAGLPHKSFQPEKFAEEVDKLSTRFRDGHRSPSNLAVKGTAAEDGVFLPEYHRRIPADGFSVYAEGIWEQIVNNKDLDLPTQQELLAQFRCDEIAREVLVLFDQTIGPFEVQQADATRSGIPLILAGLGAAMRTARGKTMNSFETEASRYHKRVFATKKSELEEKIDTRLKALFTGQLSAAHKSGVAEFSEAVSSAVKAGQKKGASYDFAEIVTRERKLAIEKFEKEAGTVVVEGAPWSDYKQELSLYQKDLEKISSQLRKDEMRRLATRVERWVRSRLGDSIDLEFNALGSGRGGSRAPEDGEKPSEKTIWDRIWSLFVNTVLDAERRFTERAKSFDASLEEVDVGLWRLRRKSWGVLRSKIDEEMMEGNILLKLRENFEDKFRYDDLGVPRIWRPTDDIEGIYTTARESTLNLIPLLARFRLNETSAPPPLDKWIGHMPSSAGAADEEDLAPIGGVDEDDGKSLEEEMTMLSEAKRQDLTVRFKKAADGVYVEAKRSAIGGITQVPLYFYGLLLALGWNEIIAVLRNPIYFLFLLVIGVGAYVTFRLNLWGPMINMAEAASRQAVEEGKRRLREFLESSETGRQAMAMSGRNSTHVEEYEMSSNLKSKGRRSTADDDDDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLG6</accession>
    <name>D4DLG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="1">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000505">
        <property type="protein sequence ID" value="EFE37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017947.1">
        <property type="nucleotide sequence ID" value="XM_003017901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLG6"/>
    <dbReference type="GeneID" id="9579825"/>
    <dbReference type="KEGG" id="tve:TRV_08040"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25742" checksum="EF4DEB46FECA7E30" modified="2010-05-18" version="1">MQEVDLYLMHFPYAYAIKDGYATQRTPDGKPVIDVPLSRAYDVTWAAMEKLVEKGKAKLIGLQTTGVSNFSSPKLKRLLQTAKIHPVVNQVEIHPYFPQKGLVEYCQENDIHVTAHCPLGGAPIPVLIGRHGPGPLEDPTLLRLAQKYDKTVAQVVLCHTICRGISVIPKTNNPKRIIENFDILFEMDEADFKLIDNLMGERGERGIRNLETRDYLGFDNFNEEVEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ8</accession>
    <name>D4DLJ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017906.1">
        <property type="nucleotide sequence ID" value="XM_003017860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLJ8"/>
    <dbReference type="GeneID" id="9579784"/>
    <dbReference type="KEGG" id="tve:TRV_08072"/>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="498" mass="53844" checksum="255EC7E6AE3C4709" modified="2010-05-18" version="1">MAASASPNRGITVFSGGSAANNLVDVFSALRESKNCPLSYIIPISDNGGSSSELIRFFGGPGIGDVRNSPTDPERAGIKTLFNHRLSSNASSAHDEWYSIVEGNSSLWQAITPAKKELIRSFLNLLNLEILKRARPPASTFDFTSASVGNLFLTAARLFSGSFESAIYLLASICSVPIDSVRVIPAINSNFSHHISASLEDGTVIVGQNSISHPSEASSIQPTPSSRRPSLMLADGDDPYLEPEDPLYEESHLPGSLPTLRNKNIQFSKSTVDELPSRISRVWYINPYGQEIRPPANPRVLEALRSSQAIIYSIGSLYTSLIPSIILRGVGRSIASGPARYKILILNGSLDRETGPTSQPLSASEFVEAIVRAAEESCSHKRRSSVPKDSCTHKPSTPQISAPSEPYTSYVTHILHLDGPGTPQVDRVRLNEMGIECLRLYGRKVVNDEGSVVGMKYDPAGLVQALEVVLGKKGDAMVRSGLSGERSRRNTMEVVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLM5</accession>
    <name>D4DLM5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_08099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000514">
        <property type="protein sequence ID" value="EFE37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017888.1">
        <property type="nucleotide sequence ID" value="XM_003017842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLM5"/>
    <dbReference type="GeneID" id="9583787"/>
    <dbReference type="KEGG" id="tve:TRV_08099"/>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="148" mass="16580" checksum="402154BDB5DAF799" modified="2010-05-18" version="1">MVKKRASNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAVSDISDASVFTKYAVPKMYLKLQYCVSCAIHGKIVRPQLKKEKKATDEPFFNNHSVRSREGRRNRAPPPRLRFNKDVKKLNPQQAAANAKSAQAAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLQ1</accession>
    <name>D4DLQ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000517">
        <property type="protein sequence ID" value="EFE37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017869.1">
        <property type="nucleotide sequence ID" value="XM_003017823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLQ1"/>
    <dbReference type="GeneID" id="9583764"/>
    <dbReference type="KEGG" id="tve:TRV_08125"/>
    <dbReference type="HOGENOM" id="CLU_076340_0_0_1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049511">
        <property type="entry name" value="PGH-like_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17660">
        <property type="entry name" value="BTRD1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055972" evidence="1">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="32853" checksum="476AF452151C1EFA" modified="2010-05-18" version="1">MKFSIFSAASLLATAALAGTAWEERHGLAFDPFKHTFDQLTKKGYRPTYLTGDAESNGDPRHNGIFKTHLLDGISWTAEYGYEPKKFGETIKNLRSEGYFPMQVQGYNIGKEPTEGHLRRFNGIWNKYIDGRTVRWELLVDSTKDQVTEALHKFPPKGYRLVSLSGYGIRSEQRFTAVFQRTPGPDWKAALGMRRDEYQRRTEEMRKLGFFPADLSVYNIQGTVFFSAIWQQEGGKLDKSMSRFGMTAKELEDWFNQYKEKGYEPMTVCGYLEHDSLKYAAIIGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLR5</accession>
    <name>D4DLR5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_08139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000518">
        <property type="protein sequence ID" value="EFE37199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017844.1">
        <property type="nucleotide sequence ID" value="XM_003017798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLR5"/>
    <dbReference type="GeneID" id="9583738"/>
    <dbReference type="KEGG" id="tve:TRV_08139"/>
    <dbReference type="HOGENOM" id="CLU_073620_0_0_1"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056605" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="257" mass="27841" checksum="AEF4AAAF0E73731C" modified="2010-05-18" version="1">MRFSYSSVLLSLLALSSSTLSAASSLTVALPSSVRIGSLPSSTYATLTTISQPNGPLKAPLSHLSTFVFDDISPPIASTGSEKPISYLLDIHSKSHVFAPYRVDVSSETGKIIGVWETYRGNPWDNKGAEKIISGGDYEPEVVVVEAKVLAKKDFYEQREKFSPLALLRNPMLLLAIFALAVTFGMPYLIENMDPETREEFEKQRAAKRNKPANPAQGFDLAGWMAGTNPNLIDTGKPAGSSGREQESAAAAMRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ62</accession>
    <name>D4CZ62_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025728.1">
        <property type="nucleotide sequence ID" value="XM_003025682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ62"/>
    <dbReference type="GeneID" id="9581971"/>
    <dbReference type="KEGG" id="tve:TRV_00099"/>
    <dbReference type="HOGENOM" id="CLU_099558_0_0_1"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17172" checksum="B2A92B2EB28210BA" modified="2010-05-18" version="1">MAGPQGALATSFKAVRILQAICLISIIGMTANFIAQMVNANATPPDVLIGTLSVTVIAVLYCAITFILFLDGALPYLINLGLDGAHLIAVVVVAVTVGKPLSYLNCNVIGQVTGGHSSVYDFANALGQSLAKDGGKISYTHWIGASKLTCYEMKSIWGLSIALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZG6</accession>
    <name>D4CZG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025568.1">
        <property type="nucleotide sequence ID" value="XM_003025522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZG6"/>
    <dbReference type="GeneID" id="9581806"/>
    <dbReference type="KEGG" id="tve:TRV_00208"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="508" mass="55558" checksum="25BF34F3DA5DC9E8" modified="2010-05-18" version="1">MDVTVTNDGATILSLLDVEHPAGKILVDLAQQQDKEVGDGTTSVVLIAAELLRRGNELMKNRIHPTTIITGYRLALREAVKYMNENISIKVENLEKDSMLNIAKTSMSSKIIGSDMDFFAKMVVDAMLSVKTTSPKGEVKYPVKAVNLLKAHGKSATESILVNGYALNCTIASQAMPTRITDAKIACLDMNLQKERMKLGVHITVEDPTQLEKIREREAGIVIDRIEMILKAGANVIFTTKGIDDMCLKMFVEKGAMAVRRCKKEDLRRIAKATGATLLSTLSDLNGDEKFETSSLGYADEVVQERISDDECILVKGTKVFSSASIILRGSNDFQLDEMERSVHDSLCAVKRTLESGSIVPGGGAVETALHIYLEEFASTVSSREQLAIGEFAQSLLIIPKTLAVNAAKDASELVAQLRSRHAHALRVQEGVANEADKAIAKQKNYRNYGLELLKGRVTDSVKAGVLEPSMSKVKQLKSAVEACIAIMRIDTMIKLDPEKREDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZK0</accession>
    <name>D4CZK0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025602.1">
        <property type="nucleotide sequence ID" value="XM_003025556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZK0"/>
    <dbReference type="GeneID" id="9581840"/>
    <dbReference type="KEGG" id="tve:TRV_00242"/>
    <dbReference type="HOGENOM" id="CLU_069397_0_0_1"/>
    <dbReference type="OrthoDB" id="4172513at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="27765" checksum="A59B042F9668F915" modified="2010-05-18" version="1">MAHPKEEPKEDAWIEVETEPEPPGTFLESPYASKPAMFRTSDGTIFSVPEGFISKLPALTELRKENQDGVTDLSFDKEVAHVFFHCLCAGTYDVGCGEYYHSTWNDPGYCKALLELKRSLRVHAVAKQYEFFSLKIGAETHMKDHYKWLPLAIFMDHIRENLAYFKDDMDWLHKQVQIVLEATFEGNSSFYESSAFLENIGHSPEFDRLLAQVMGKMYRSMHTDDTEEIAWTQSKENWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D046</accession>
    <name>D4D046_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025379.1">
        <property type="nucleotide sequence ID" value="XM_003025333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D046"/>
    <dbReference type="GeneID" id="9581614"/>
    <dbReference type="KEGG" id="tve:TRV_00440"/>
    <dbReference type="HOGENOM" id="CLU_025740_0_0_1"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44264" checksum="A2DE60EF811BC0EC" modified="2010-05-18" version="1">MSDYNRQRSSGRSALGYWVPLVITVGVATAGLAAWVLSERQSDDDDEGLSYHDDNAPITMDPGSGDSYSRGVTTATDDGSVMSRFQGAWRRTPSPKQLFDGASRSVVAGVTAAGAMVGGALSSIREEGRSEYDDHDQQQQQQGRRDEELAARDAPRQSQPTPGALPAETTGTSQSRQGPKRVKTVAIVVSSVLPDSELDEQISGHASILAHLPEHIEPETSRIFVLIYAPGVQPSAAGTSKPTLSITSSYSNIASEEAAGAESTEVTPLTTVDPDPTTSDETQQPTALYHTLYSQAQAIVDNETMIMPFSTPGGHVHILRHLSPEIVYIQESLTGNNGESVNQISGWVRQVVVVIGDEGGRGGLIDSDDESALADKGERWWQKEGVTGLGKRITVVDGVRIGEEWKRRVCGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D069</accession>
    <name>D4D069_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025402.1">
        <property type="nucleotide sequence ID" value="XM_003025356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D069"/>
    <dbReference type="GeneID" id="9581638"/>
    <dbReference type="KEGG" id="tve:TRV_00463"/>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="38897" checksum="F214C7ED75A39535" modified="2010-05-18" version="1">MAASTSTSGNRDLPASKYDLSTYWGRVRQSAELCDPRTLFVSADGLENAKKLIESYKGGQLLSMTPELWHAKKVVDSTLHPDTGEPVFFPFRMSCFVLSNLIVTAGMLTPGLGTTGTLLWQIGNQSLNVAINNANANKSTPLSTSAMVKSYLMAVSASCSVALGLNAMVPRLKVAPNTKLILGRLVPFAAVATAGALNVFLMRGEEIRQGIDVYPAEPKDRSAGAEVKSEAGEVQSLGKSKKAATLAVGETAISRVLNSTPIMVLPPLILVRLQQMQWLKTRPRLVLPVNLGEFFKTIFVCVYSTVMLTLYLAGLILTTSIFALPLALGAFPQRQAVQASSLEEEFWGRGGSTGLVEFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D086</accession>
    <name>D4D086_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar carboxypeptidase Cps1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000024">
        <property type="protein sequence ID" value="EFE44731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025342.1">
        <property type="nucleotide sequence ID" value="XM_003025296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D086"/>
    <dbReference type="GeneID" id="9582953"/>
    <dbReference type="KEGG" id="tve:TRV_00480"/>
    <dbReference type="HOGENOM" id="CLU_021802_2_3_1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08011">
        <property type="entry name" value="M20_ArgE_DapE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF32">
        <property type="entry name" value="ARGE_DAPE-RELATED DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="196"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="422" mass="44998" checksum="6C9BF7D8DA5F9831" modified="2010-05-18" version="1">MEEQAAKLRSKLRLQVSSRREAIVRVAQKLVAAPSPCPPGNTTLAATVAIQLLEEAVPDVQITRHVTGAGIVNVVACISSGRPGKRLVFNGHLDTFPLGEDLKWTVPPAGGVVKDGRLYGRGVSDMKGGIAASIVAATILSENRNAWSGEIVLTLAGDEESMGKQGTKWLLDHVEKATGDAMICGDAGSPRVIRFGEKGFVWIDIEAVGTPAHGAHVHRGVNAIDRLRKALDAVYELEKVPVNAPPEVSDAIDAARDISEALSGSGESDTLQRITVNTGTIKGGVSPNLIPSSAMAQCDIRIPVGVSTEFIEKRLNDMLGPMAGISWRILRTSEPNYTSPNEQICRLAEIVSAEVLGQQAVCNMRVGASDSRWYRAANVPTVVVGCTPNNMGAADEYVEIDELVNISQIHTIVAYEFLKNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0H5</accession>
    <name>D4D0H5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025254.1">
        <property type="nucleotide sequence ID" value="XM_003025208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0H5"/>
    <dbReference type="GeneID" id="9580747"/>
    <dbReference type="KEGG" id="tve:TRV_00570"/>
    <dbReference type="HOGENOM" id="CLU_025069_0_0_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056067" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="19"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="169"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="579" mass="64777" checksum="60EFCA20D7920382" modified="2010-05-18" version="1">MRHRTLTALLAGASFAFAAHKPFSIQDDVLANPQFEVVFPDEYILESDAQLRLVKSQSKHKDATNTPSQPSDAPNIVSQDERSELSEQAPLQGESEADDEELMKDEDDVSIDSYHEMVLDGQRFLCGIPSVTPTGKDNTSTSTPNPEDEALELARATNRGLELLSDLEGKCLYYAAGWWSYSFCYMKEVRQFHARVPGQGVPVYPPAEDPDSKTYVLGRFQKNSERGQPTAASTEVAALQTKGESWYLVQYLERGTICDLTRRPRKIEVQFHCHPQSPEHIAWIKEVTTCSYVMMVYTPRLCNDVAFQPPQVEKPNSIKCREIISPEHVSTWEAALASKKERAKKELVEATDEPFATVGDIQVGAMKTVGKDGKRIEKDQFGFGGEPKVKVVARSEGGKVKVLSKETLKKHKVTSEKFERLKQELDEAADGEDWRLEEISTSRGEGLRAIIDDPFDDVGREEEEGEGEGGPDTQAQNEGKADKDTSKETSPEDQQQQKQQQQTKKSTKKQQPKSNKVRMLRKLQGQAASDETAPEAGSDETYKTDSKVAKAKKEKLHKTDKTGKSDKAEKKEKDEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R0</accession>
    <name>D4D0R0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025173.1">
        <property type="nucleotide sequence ID" value="XM_003025127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R0"/>
    <dbReference type="GeneID" id="9580666"/>
    <dbReference type="KEGG" id="tve:TRV_00655"/>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="31995" checksum="DC046C7BED60BE71" modified="2010-05-18" version="1">MPLDTSTTYRLTRLRLDGRRWNELRLLQAQISTNPASSGSSYLSMGNTAVLCTVHGPAEGKRSETAGAAGAVINVVVNLAGFANVDRKKKSATGSGGGDRQATTELATLLRDAFQPHIHAHLYPRSTISVHVSVLSSDGSLFAACLNACTLALVDAGIPMPGLLCACTVGMSGRASTPAVTAESAQIGEINESLDPLLDISAPEEVELPYMTVANTNPMPDITVPKDEEDEEEDDYDAENENQMLSIVHMDSGVHVSYLETMFAVGIDGCKQTREILNGVLKAAGKRVLMGEAASGPDYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R5</accession>
    <name>D4D0R5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol binding protein (Osh7)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025178.1">
        <property type="nucleotide sequence ID" value="XM_003025132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R5"/>
    <dbReference type="GeneID" id="9580671"/>
    <dbReference type="KEGG" id="tve:TRV_00660"/>
    <dbReference type="HOGENOM" id="CLU_012334_4_2_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52233" checksum="D1B1F893D1381DF3" modified="2010-05-18" version="1">MVVVDVDLVGPIADFYSFMAHPETLLPMPEIDDPLQRFVSVVKFYLSGWHIKPPGVKKPLNPILGETFTGYWEYPDGTKGYYIAEQTSHHPPKSSYFFMAPEHDIRIDGTLKPRSRFLGNSAASMMEGISYMEFLNRGKEKGHGERYIITQPNMYARGILFGKMKYELGDHSYVKCPENHFVADLEFKTRGYFSGTYNAIGGTIKNDETGEVYYELSGLWNGEMFIKDVTNILLKFHGQTGQKELLFNATHAKHTPPLTRPLEEQSSRESQKLWYSTVQALLERNQDLATEEKTKIEDRQREEAATRANENIEWRPKLFRAVQGGPGGSEEGRENLDWIINAHIDPHNPSKAVEQILAFTAILPGQKVNHELDIPPQAPKSVKPSQAQESLLDLDSNDAAPGNAQHKPQPSEDLLGNPVKNHNGSNNPAGVGAGSGMMAPLQPSMSTSNTAQQKPTPNPGMGGLFDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D144</accession>
    <name>D4D144_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025053.1">
        <property type="nucleotide sequence ID" value="XM_003025007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D144"/>
    <dbReference type="GeneID" id="9580545"/>
    <dbReference type="KEGG" id="tve:TRV_00791"/>
    <dbReference type="HOGENOM" id="CLU_729955_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="42895" checksum="28247571052F6F56" modified="2010-05-18" version="1">MLEVHYSASCSCGLLLLLHLFFFISPLLFCLLPCLLERTVSSHYGVLLLSLSQPRWLSTCPPPALTSEVWSTYVPPVSPPSSPQEGKKASKEQKTVQKKTKTVQEARQAGRQAILRRKRSKNTQTKRKKEKKEGKQKEKETQIEKKMGDEARTRLTSWRIAPVFRQGGLVGPDSLSKKEQPSRCRGRAEWTDGKDSSRARDPSPGSYCTYIPPCDIYRLPYYISILTYGYTQLRLHKECYITILRTLLFFQAWGKRALCMAVNAGYAARSSACLYLDAVRYFSCLMLHASAAAGCCWFAGGTNRDALDQRGLPPGCNANQIQSSVVFTHFYLFCLLSFSLTFTRSRRLFVRSYRTAIWRKYGTGNVAREVSPLPSQVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K5</accession>
    <name>D4D1K5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-hexosaminidase</fullName>
            <ecNumber evidence="8">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Beta-hexosaminidase that shows a broad substrate specificity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024881.1">
        <property type="nucleotide sequence ID" value="XM_003024835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K5"/>
    <dbReference type="GeneID" id="9580372"/>
    <dbReference type="KEGG" id="tve:TRV_00956"/>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055247" description="Beta-hexosaminidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="11">
        <location>
            <begin position="214"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="605" mass="68580" checksum="78AFF1DF382A9935" modified="2010-05-18" version="1">MLWIWVAGILGLFGRVEALWPQPSEYSHGNKTLWLSPSVRFTYTNNQRSFIYTRPSYAGINWIPGGWLNLLQNPWGSAEQTVAEPLPNVEQFVEDAIKRTKHAIVNSKFVPWKFYPRHQKFEPLVDGQHPTIEEVIINEASKTSQQWSPRNYVNGDEKYEIRISEDGEVQISSRSPIGTIRALQTFQQLFYSHSHSKSYTPFAPISISDSPKWRHRGLNLDISRNVIRPEDVKRTIDAMASVKLNRLHFHAADSQSWPLDIPSIPELAAKASYHPSQVWSSSELEAVQLYGLERGVSVFLEIDLPGHTAAVGHAFPDLVAAYHMDQWEKYAAEPPSGQIKLNSSAVYQFLDLLMADLIPRVSPLTEYFHTGGDEFNLNTYLLEINLGSNDRRVLTPFLDRMITHVHSSLRSSGVTPIVWEELVLDWDLNLPSHKTAGETGGVIVQAWRNSSAVKHVLQKGYQTIFGTGDAWYLDCGVGTFLNPRPGSKAVQNPYLDWCAPTKNWKHMYVYNPLKDIPVELQSLLVGGETHMWSELVDPVNMDQMIWPRAAAAAEVLWTGPRSPDNIQDASYRLVKWRERVVSDAGIRAAMVQMTYCLMRESGCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L0</accession>
    <name>D4D1L0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024886.1">
        <property type="nucleotide sequence ID" value="XM_003024840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L0"/>
    <dbReference type="GeneID" id="9580377"/>
    <dbReference type="KEGG" id="tve:TRV_00961"/>
    <dbReference type="HOGENOM" id="CLU_040072_0_0_1"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="358" mass="39356" checksum="73E76E06BAC51690" modified="2010-05-18" version="1">MSSSKLPRVAALRRQQLRLEFASIKVSPPVGVYVSLSPSDPALWSGVLFVQKGTMRLFQARLPTIISSLSSVIGPYASAILRFQIRFPPLYPDLPPLVTFTTPIFHPLVVPLTTQTYSNRPSDLDSVTGTIEEQLPPGGFSLRHGFPQWFIKTERSNVGSLSSSRSTSGQKPGNIGVHVEQDSGLVESSTDEIISRISPLPCDIQDPKKSGVTDVTALDLLEYIRSTFDDETVLDSIPLEATGCPNAWHAWSAHRRHPRTGPATERRSSKDAGVSSPSTLGRTLSPDSIQRSSPQARSPGEWNWEGVWLKRVKENIHHSFLESVLFGSSSRAGSSGDDMVRMTRFKYVLECHSPYAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1P0</accession>
    <name>D4D1P0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024818.1">
        <property type="nucleotide sequence ID" value="XM_003024772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1P0"/>
    <dbReference type="GeneID" id="9580326"/>
    <dbReference type="KEGG" id="tve:TRV_00982"/>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="333"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="556"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126128" checksum="FD60350F8DB2C711" modified="2010-05-18" version="1">MENRGKRKRDDADGQDSTPLVKDHGGTDNGALAKIGTSNTSSHSEPSSAIPWPEEFKALSRIHRALNVVYTFCCTRQHYTTTFEKIRSSVESQTGGRPLTIEDVAKVKFLIPQSVRFELSDTGVISIMGVAEARKKKVPEIWNDWEAEGMGSNGSHGGNKSPAAELLFEFVDGDLKPESQPGVGLGGYEDIRTPVYSQKKMVALIEKRNKKFTTAIDTFLASCRQENADPVQRLEAGKDVYMPLSPDSGCNTPAAAKLPAQIPKIRPSIAEIISEIKEQSWYYDQIVKGGYRIFDAKKPVFGDLDFLLSQNLVNALYNTRGITQFYSHQAKAINDLHDGHNVIVSTSTSSGKSLIYQVPMLHELEKNPHSRGMYIFPTKALAQDQRRSMLDMLKYMEGLEHIMVETFDGDTPMASRNAIREEARIIFTNPDILHVTILPNESLWRNFLKNLKYVVVDELHVYNGLFGTHVALIMRRLRRICASIGNSDVKFISCSATVANPEEHMKAIFGIDEVKLTDIDGSPSGRKEFLCWQTPYKDPNDASSGRGSSIDESAKLFCQLILRGVRVIAFCRIRKQCEYLLNAVKDEFRTLNRSDVSRFVMGYRGGYSPQDRRKIEREMFEGKLLGIVATNALELGVDIGTLDAVITHEFPHSISNFRQQSGRAGRRNKDSLSILVAGQSAADQHYMNNPDDLFTKPNCGLLVDLENELVLEGHVQCAAFEMPIRPENDSTYFGPQLAHLADTRLIRDDMGFYHCHERFRPNPSKFVSIRSIDEGNYAIIDTTNNRNVVVEEIDDARVFFTVYEGAIYFHQGNTYLVKELNTTKRFARVVRAHVDWITEQRDFTNVDPIETEAIRRISRLSDYRAFFGKIAIHTLVYGYFKKDRKGRILDAVALDTPPIDKMSKGLWLDVPKTALEILSSHNLNAAAAIHAAEHAIISLLPTFLISSPGDIRTECKVAKKELGPKHQQARGSNRDQDPRTRNHFFHPLAPPIPRRQRQARLVFYDAKGGSSGSGITSKAFEFIDSLLVRADSRIDTCTCTAAQGCVECVCNELCPEMNLVISKAGASVILKCLLGLKVDVDSLPWGTELDRGYEPGPGSELAQGLETIIEAVEVAGASGKEIRVYDLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1R2</accession>
    <name>D4D1R2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024840.1">
        <property type="nucleotide sequence ID" value="XM_003024794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1R2"/>
    <dbReference type="GeneID" id="9580318"/>
    <dbReference type="KEGG" id="tve:TRV_01005"/>
    <dbReference type="HOGENOM" id="CLU_172736_1_1_1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="56" mass="5954" checksum="4A128B9B9E73D1D3" modified="2010-05-18" version="1">MTVLGGTAGGIYFSLPGKQSKAQAPPIKASSKDEEAFIQEFLKSVETEDSKAKAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X3</accession>
    <name>D4D1X3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024726.1">
        <property type="nucleotide sequence ID" value="XM_003024680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X3"/>
    <dbReference type="GeneID" id="9580251"/>
    <dbReference type="KEGG" id="tve:TRV_01075"/>
    <dbReference type="HOGENOM" id="CLU_1492608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="181" mass="20643" checksum="AEC389B0446223D8" modified="2010-05-18" version="1" fragment="single">PMYGYGYRQSSKEDMRLEAYPVKQTAYLSMTSIFIRRGNFAYDPVKGFLESPWPQGGGERQKGIHEFAEFMGFTIYLYSYLLRTEYCSLDISTTGSKLIQRKHPAKQLANCDVFQTQKKNESFKWEKGDLQMLNIMLPAGDCILSSPSKLREPIHICADELALTQCLDCGEEKRTALLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D235</accession>
    <name>D4D235_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024674.1">
        <property type="nucleotide sequence ID" value="XM_003024628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D235"/>
    <dbReference type="GeneID" id="9582849"/>
    <dbReference type="KEGG" id="tve:TRV_01137"/>
    <dbReference type="HOGENOM" id="CLU_028989_0_0_1"/>
    <dbReference type="OrthoDB" id="3796887at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012985">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08192">
        <property type="entry name" value="Peptidase_S64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="635" mass="70134" checksum="885A9AA9678DAE70" modified="2010-05-18" version="1">MVSITYPHTSQVVYAGPLPLIATSLSEAGVSESQPQRKWLRQCNHSSSLDDSPLPDLEEPEIIYEGHRVGGPVLCRLPAATFPITSADPITHVFDSEMRGKIMEAIQESNIDFQAMSVLKRRWRESRDKPLPFILIIAKAKYNRTVEDTWFQLYGKIRAICTSAGQEVNVEIGDPIAYIPRISSAILLSDTIVQHWPALKPRVLEIINDKRWLTLDVLRRGPIDNEGIITVVITIPECSTNDAYSWRPIRDRIVDVLSTAGLDNVAVEIGRGAVYSSHDIDKNNNFFDESGPSAKARFGGSLAGLHDSKRLGSFGGFIVLDFSDGKSRTCGLTCFHCVVNDETDSPAIETWQTHGLRPSDPKNNIEVSHPCRRDYEDIVAHCREVIACLQTPEYYRVLALANDPDRLLSRQEQGVLDHGLIFITSHKEKIRIADEFMLERMNYFGKVYAGSGLRLDEDSHSLDWALIDVSPERVSGNKLPDGLVSPYFNPTIHGGHVTEANFDTVSGQNVFKLGRSTGFTKGIMNGIETTRFRSCGLGGQSGDALSQSYDIQWAIVPHNGKGLFSGQGDSGAFILDSNASMVGLLFAGNTFCAATYMTSVAALFEDIKRVTGACRDKKEKVVKYDTKESVMAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D239</accession>
    <name>D4D239_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024678.1">
        <property type="nucleotide sequence ID" value="XM_003024632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D239"/>
    <dbReference type="GeneID" id="9582853"/>
    <dbReference type="KEGG" id="tve:TRV_01141"/>
    <dbReference type="HOGENOM" id="CLU_590472_0_0_1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="428" mass="46531" checksum="9FF88172C4936648" modified="2010-05-18" version="1">MAIELAGGGAASQTALQLAARRGNHDEAKLLLQAGNDANFSPKGTEYPLAYAIESGDAETVKVLLEYGANIHQASKRHGNALIASIKRGEEEIFDIFLGKFDPNSTDRVGAPALYVAAVSGHEAMVNKLIRRGADVQACHDTIFSPIMGAGLGGSSRIVETMLQNGANSDHAALFAASSVGENELVTQLLLHGADVGRCTLPYDRDLPIHAAMLQGHETTVRILLAAGATLTSRYFPYVFLETASRRHFGISRLILNEHLHGDIRLCLGTSPFSSRSSHIPIALLLSTLKVGARTGNASLAWEFVEPYGQTTMDFMEYLLTQNSIRLPVDSPKSVLKAAIKYRNDTLLSFLLDSFEVNIPGDFPNLIELAVINGSVPTLEVLLKRTTEQAELKTPQWKLYLSRALNAAIERNNFHMVELLDCYGTFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D290</accession>
    <name>D4D290_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024624.1">
        <property type="nucleotide sequence ID" value="XM_003024578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D290"/>
    <dbReference type="GeneID" id="9579951"/>
    <dbReference type="KEGG" id="tve:TRV_01193"/>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="704" mass="79760" checksum="5F6884256C0033FB" modified="2010-05-18" version="1">MGHLACVATCSLRNWALDFEGNTKRIIESIHKAKAAGATLRVGPELEICGYSCLDHFFEADLYLHCWEMLCIILKDRSCDGILLDIGMPVMHRNNRFNCRIICLDGKILLIRPKLWLANDGNYREMRHFIPWVGPRHVEEYYLPRMVREIQGTTKVPIGDAVISTADTCVGVETCEELFTPQSPHNDMSLNGVEIMANSSGSHHTLRKLDIRVSLIMEAMRKNGGVYLYANHLGCDGDRLYFDGSAMIIVNGCLVAQGNQFSLDDVDVVTAVVDLEEVRSYRCTPSRGHQAMKAGVYTRVETEFSLSSDIGDRDTRLRPSLVIQPRYYSPEEEIALSTGCWLWDYLRRSGTAGYLVPLSGGIDSCATAMTVFSMCQLVIDAIKAGNSQVIKDCKRLADYTMELPKTPQELCNQLFHTVYMGMSKQSSKETRGRAQDLSKAIGSYHVDLDIDEVYEAQKNLVVKYLDFDPKFKSQGGTNAENLMLQNIQARSRMVTAYEFAQMLPTTRKRPHGGALLVLGSANAGEALRGYYTKYDCSSADINPIGGLDKSDLKLFIAWAEKSYSIPCLRSFLEATPTAELEPITEQYVQSDEADMGMTYDELSTFGRLRKYNKLGPYGMFQRLVHDWNHLTPQQVAEKVKRFYHYYAINRHKMTTLTPALHSNDYSPDDNRFDLRPFLYFPFYQSWGFKKIDDELARIKKQAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2C1</accession>
    <name>D4D2C1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024608.1">
        <property type="nucleotide sequence ID" value="XM_003024562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2C1"/>
    <dbReference type="GeneID" id="9579932"/>
    <dbReference type="KEGG" id="tve:TRV_01224"/>
    <dbReference type="HOGENOM" id="CLU_023589_0_0_1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="565"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="655" mass="71813" checksum="979DB944AB3982B9" modified="2010-05-18" version="1">MFHRCWLPLPNNRPKEQEGEKNEARDAASRRMTASTRRQKIKEREEEDGTTRRKQHELAAFSVAKSYYKCHLGLSVLSILIQAQEMQLSTSHSIRSNQELENEYCPPLDPALFVAIVSDYALDDQSAIQQLRETLDALKISAFEQEDAIFDPSGTSGFDFPEDASAIASAQSEPQTLGSHETNTTSLGSTVSSLGVESSNDPGQRTRGGNGDPKWSGDSTTAVKGLNRSNSEDQAQYLNEMFPSIDRYTVLHTLDKYGGNVDKAMDVLLNSSFFENGQTSGTDEDQILVPKGVEGFEHSVGNGKSRRRGKKNKNKQHLQHLSESDLSQTSLSYSSGTKPENRWDNGKKDMEFIASRTFLTMSTISSAYHSNGASLPATIRALTRDEAKKSSAEGVGDDVTRSQIAELQEEFAALSHQELVGLLRLTRNCISAANELARIMVIEPIPSLIQPEYRATGPSGSLQATTTSNTSRTPTRSSSVPAATAVRPNYNPVISRAIADRHLIASQQAFEKAHSAYRRGKSDRLMGGAAGYYSSLGREHFEKAKRESAIAADALVYSQSTSNVLDLHGVSVQDAVRIAKRSVESWWESLGDEKYSNRLRAQPGARSYRVVTGLGRHSKNGTARLGPAVARCLVREGWKVEVERGALVVTGQVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2G4</accession>
    <name>D4D2G4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024557.1">
        <property type="nucleotide sequence ID" value="XM_003024511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2G4"/>
    <dbReference type="GeneID" id="9579881"/>
    <dbReference type="KEGG" id="tve:TRV_01269"/>
    <dbReference type="HOGENOM" id="CLU_1278440_0_0_1"/>
    <dbReference type="OrthoDB" id="4169862at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="219" mass="24674" checksum="08F9EB1D8D0F8B13" modified="2010-05-18" version="1">MELGFGDQDLIYEEEAKRLAKSAPVPRSMCLSCSKLVAESPMLECSQAHPSTKCFQCVKANKPCHTIPPQFRGDLERIQAFAREIHVRPSQKATEQLQEFARKYVARIEAYELKEPTLEVYAPYPVPRSIPLPVPIDSPVKAANPMNSSVSTEDKLASKARDLQQVNHMLDKIMELVSRNMDLPLENGNIEKNSEATWLHVNQGTIHGNNVNEAPKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X2</accession>
    <name>D4D2X2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Origin recognition complex subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024465.1">
        <property type="nucleotide sequence ID" value="XM_003024419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2X2"/>
    <dbReference type="GeneID" id="9579687"/>
    <dbReference type="KEGG" id="tve:TRV_01428"/>
    <dbReference type="HOGENOM" id="CLU_015257_0_0_1"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="306" mass="34588" checksum="F30CFEF887FB5C4F" modified="2010-05-18" version="1">MMKDDTILAKQAYLGISVSRQKMRDIFSCVDWLVAFTRNMKSQKSANHSECIILALGGELLESKILLETLEAARKLNSEELDAAFGLISNLSAESAAILDEIRELMHTKKSKGVLRSQHDAQLTRHNTTVVGQRVKLTKGKAKLSNEELKYSELVDRLCDSIQKHLSEKLINPKDLFLHECLIFDFKSPIRNTFTPKCRHTVERALSHPFDYLDSKEDGEIEALSAGQPPISILYQLYLESGAVVNVYDLWRAFYAIVGGEDADRCEERVAFSIFYQSLAELKMMGMARISRKKTDHLAKSAWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R7</accession>
    <name>D4D3R7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024129.1">
        <property type="nucleotide sequence ID" value="XM_003024083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R7"/>
    <dbReference type="GeneID" id="9577126"/>
    <dbReference type="KEGG" id="tve:TRV_01729"/>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="50536" checksum="49A1408B98098196" modified="2010-05-18" version="1">MAASDQYRQGPSDSSQKHPPASPTYVLRGHANPIHSLNFYGSNSRLISGDADGWVVVWDMTSKRAVATWKAHEGSILAVVGIEVNLETGVERRILTHGRDHKLCVWRLNEKDEDIVGKILPLDTQNSPQDGNKPWMLHSLSVNALNFCGFAYCFLPHKREMQSEDAINAENQMLLAVPNALNTGGLDIFHLPSEKRLCVISPEKEINTGMVMALEMFIPPEGEDLYIVSGYEDGSAMVHACRGAIDRLLIAEEDNSNSSWNWELLYTNRPHSQPILSLDVSPCSERKCFITSSADAMIVKHAIPRLPPTLEPDVTNIRSAVESAHLKAVNTKHSGQQGLRIRSDDKIFATAGWDNRIRVYSCKSMKELAVLKWHKEGCYSIAFAQVNMDTGDIETTRGAIGPNTIQENKSTDLTIRNEPRSLAEIKQQRSIKAQLTHWIAAGSKDGKVSLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D489</accession>
    <name>D4D489_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023962.1">
        <property type="nucleotide sequence ID" value="XM_003023916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D489"/>
    <dbReference type="GeneID" id="9582655"/>
    <dbReference type="KEGG" id="tve:TRV_01904"/>
    <dbReference type="HOGENOM" id="CLU_2291046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055313" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="11072" checksum="D7EE4DAD7F13F236" modified="2010-05-18" version="1">MRFSAVSVLALATLAMANSELDPKMSILPYTSSMVMTSAPAPYPTGGSPTGIPGTGTGSSTMPHNTTSTAETSTRTGSGPSSSMTSTSTSTGLAATAGPAIAGVIGGAAVVAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4P2</accession>
    <name>D4D4P2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000106">
        <property type="protein sequence ID" value="EFE43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023795.1">
        <property type="nucleotide sequence ID" value="XM_003023749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4P2"/>
    <dbReference type="GeneID" id="9582372"/>
    <dbReference type="KEGG" id="tve:TRV_02058"/>
    <dbReference type="HOGENOM" id="CLU_1200563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="231" mass="26049" checksum="CC866235189CB22B" modified="2010-05-18" version="1">MLIHHVLSPFEPSSSPFLPSLGSAQLRQFDTAFSSSLQLQLRATFLLLIIILSSATSKRKKKYARWSVKKATLYGVPHTPYMDELHFILTSYYLSCELSTSLALRSIGLDQERSKGKKKGERKATKHSPSSWMGIVSKGVGEFVSSSDEASILALTTLYGVILQPWKGFHCLVYGTFHSIILSFGIAIVACKARRYIFHFSNMTLQFLSFSLRRRNKASQAARLMVEWIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4U8</accession>
    <name>D4D4U8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023728.1">
        <property type="nucleotide sequence ID" value="XM_003023682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4U8"/>
    <dbReference type="GeneID" id="9582296"/>
    <dbReference type="KEGG" id="tve:TRV_02115"/>
    <dbReference type="HOGENOM" id="CLU_1856740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="138" mass="15658" checksum="00E414A91443344C" modified="2010-05-18" version="1">MIADSMDSNFNQILDIELPVSQREFLVFIESRKRSKSRLGQVPAQLPDRGRKIDGRTAIDVGDMRTCRVLWLELLPGKSEELLGVGGMMLDLGMSILETCICMMTYRYHPASPGTAEGEVEKREREISFLADERNEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D532</accession>
    <name>D4D532_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023693.1">
        <property type="nucleotide sequence ID" value="XM_003023647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D532"/>
    <dbReference type="GeneID" id="9582241"/>
    <dbReference type="KEGG" id="tve:TRV_02202"/>
    <dbReference type="HOGENOM" id="CLU_444230_0_0_1"/>
    <dbReference type="OrthoDB" id="4174411at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055336" evidence="2">
        <location>
            <begin position="25"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="601" mass="64317" checksum="5B95B6FF452428E2" modified="2010-05-18" version="1">MRFTPSNLLSLLAVGAILQPVVVPRAITTGLINGRDESDLTKCDVTLGCVDETIQTPSLKDHAVIPALQKRKGRRPGSNNRPNRNGHGKPSKPATDPTTSPKPGPTTKPSSVSTTQPAKTSSTTSKAEPTTSSKVHSATSSKVVSNTRTTSSVTSSRSTSASTSRAASTTKSVTSSATTSSSQTSAHPTSSAHSTSSSGENSSIKSEEQSATPSEKPSITSSTSTTKPTSEAELTTTSEETHTTSKSGNTAVPTLSEKGSATRSESATTDSSYTPVPTSSETDVSSSLDEYPTTESTSTLVSTSESEPTTTLDKHTTTKESSTPVPTETASRTSSETDPTTASTQEPTSTTEPGLSHGRTDNKNTSILSWEEYMRDGLNAINRFKNAIQNKEPDSEAGNFEDNYKIEHDNIMIGELVKNDGGKWNLWKATGLDQSALYEGVFVKPMTPKSDRDVVSENYYNKAARTMVIANSDINVDNTADDKRLRWSELTFQGWKKHAGDDAKNLRWVIRNNVINPGTVATVKKAIELTNQNPNKRAEFKLDASNRELNDAFVALAGTVNVKGVIHMLADHHNDMEGLGLKKIHAFGPHKLLLELGRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D546</accession>
    <name>D4D546_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023641.1">
        <property type="nucleotide sequence ID" value="XM_003023595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D546"/>
    <dbReference type="GeneID" id="9582187"/>
    <dbReference type="KEGG" id="tve:TRV_02216"/>
    <dbReference type="HOGENOM" id="CLU_029724_1_0_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="144"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="381" mass="43717" checksum="58C3951F9AD39457" modified="2010-05-18" version="1">MTEQTTSAYADCKDYVAVAQLVEPVPVPAHRSHDPANNQKRTDPFQFGSRFLEEGDDVFEFNAWDHVEADPEYYEYAELQYARQRASPVSDFDRQRFNSQPAKWWNLFYKNNTGNFFKNRKWLKQEFPILGEVTAADAGPKVVLEVGAGAGNTAFPVLSNNENEQLVVHACDYSKTAVEVMRKSENYNEKNMRADVWDVTATGEDSLPPGLGKESVDVVVMVFIFSALAPEEWNNAVSNIYQVLKPGGYVLFRDYGKGDLAQVRFKKGRWMGENFYVRGDGTRVYFFEKEEVSHIWGKWTPQGGIPEFKKDDESTTADEQSSPDSGFEILNMDLDRRLIVNRQRKLKMHRCWLQGRFRKRIPPQASKEVPSTLDQPSEFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z0</accession>
    <name>D4D5Z0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023411.1">
        <property type="nucleotide sequence ID" value="XM_003023365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z0"/>
    <dbReference type="GeneID" id="9583431"/>
    <dbReference type="KEGG" id="tve:TRV_02513"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_5_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="208" mass="23721" checksum="1B15A274F0183972" modified="2010-05-18" version="1">MIVWHQLIRTRGGAIVYRIALYEPDFVTHVFSVCTPYWPPSKQYLSLEQIIAKIPFFGYQAQLANGGLEDIIQSKEEIRQFLNAMYGGRTADGKPAISMEKGVLLEKLPGVQQTPLLSDEVSIPLHPPQKDELEFLNRSLDIPVLYILATNDTALRPELSRNMERNIKHLTRAEVVASHWALWESPEECNTHIKSWIEGVVFGRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D607</accession>
    <name>D4D607_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000130">
        <property type="protein sequence ID" value="EFE42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023334.1">
        <property type="nucleotide sequence ID" value="XM_003023288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D607"/>
    <dbReference type="GeneID" id="9583353"/>
    <dbReference type="KEGG" id="tve:TRV_02530"/>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="28964" checksum="8211935BF0078304" modified="2010-05-18" version="1">MAFVNEAEKGTRADSALNESSVPTTRPEADDFAHGTSIQTSAVASQENMRMPEGEQGQAVQGTVVDAKEAEPQPSPQQLSPGHEQQNQQPDSKPEAGGPTSISPEEAGQSSIGASVEGQPSVSLSQSTSSNDGPTLLLNILLTSGGKHPFKLDGKYLRKREVNVADNDPFSMSVYTLKELIWREWRSDWEPRPSSPAAIRLISFGKLLDDKSPLSECRFNREGPNVVHMTIKPQEIVDEEDAKAAKSTQSREHEEGERSPGCRCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D610</accession>
    <name>D4D610_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,2-mannosyltransferase (Kre2)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000130">
        <property type="protein sequence ID" value="EFE42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023337.1">
        <property type="nucleotide sequence ID" value="XM_003023291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D610"/>
    <dbReference type="GeneID" id="9583356"/>
    <dbReference type="KEGG" id="tve:TRV_02533"/>
    <dbReference type="HOGENOM" id="CLU_024327_0_0_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="47830" checksum="4A0DC99F89CBCD06" modified="2010-05-18" version="1" fragment="single">GLGIIHFITSSSLPIPKASDLGLSYPKSGGQQPVSSPAGEDKAPAPPATPPSTPQQPPTQQPPKQDTPNPVTPNPPTGNAPAPGYQKVNATFVTLARNSDLWEIAKSIRQVEDRFNKDYHYDWVFLNDAEFSDEFKKFTSRLVSGKTHYGLIPKEHWSYPSWIDQKKAAETRKIMKEKDIIYGDSESYRHMCRYESGFFFRHELMMQYDYYWRVEPSIEYFCDIHIDPFKFMKDNNKKYSFVISLPEYPGTIETLWKSTRKFIEQYPEHIAKDNNLEFISADGGKTYNNCHFLHANLLCLKWSNFEVGDLNFFRSQKYLDFFNLLDQYGGFFYERWGDAPVHSIAVSLMLNKDEVHFFNEIAYRHVPFVHCPTGEQTRLDLKCHCNPGDNFDWKSYSCEFSVLFSSPFHSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D613</accession>
    <name>D4D613_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023310.1">
        <property type="nucleotide sequence ID" value="XM_003023264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D613"/>
    <dbReference type="GeneID" id="9583329"/>
    <dbReference type="KEGG" id="tve:TRV_02536"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="253"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="46664" checksum="EBA87517EF693F39" modified="2010-05-18" version="1">MVQCTQASSKLELSLNNPAKDQETAAIPNQPNQASNGDDYTLDEFPEGGARAWAVAIGTAGIAFCTLGVINSFGVLQGWYQVNQLEDRTASEISWIGSTQAFFVFGGGVIGGPLFDLYGAKVIRPAAFLYVVSIMLTSVCKEYYQFVLAQGILGGLSNGMTIFPAMSAGPQYFNKRRAAAMGIGIAGSSLGGIVWPIVLSKMLNETELGFGWTIRIVGFVCLALLLPSCIAVKARLPPRKNQFFLWSSFKEPPYLYLVAAGFFGFLGVFTPLFYLPIYAYIQGAGVSLAFYLAAIFNAASFVGRVVTGILADKLGRFNMFFAATISSGLLTVCWPEVHTNATLVVFACFFGFCSGAVTMGMAVAFTSIPKDPRNIGTYMGMGMGIAAIAALVGPPINGALLSGRGFASMAYFSGSVNFLAAFLVVIAKHSTTKGIFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D652</accession>
    <name>D4D652_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023241.1">
        <property type="nucleotide sequence ID" value="XM_003023195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D652"/>
    <dbReference type="GeneID" id="9583309"/>
    <dbReference type="KEGG" id="tve:TRV_02575"/>
    <dbReference type="HOGENOM" id="CLU_1679217_0_0_1"/>
    <dbReference type="OrthoDB" id="4171208at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="177" mass="19885" checksum="8C75231711C68833" modified="2010-05-18" version="1">MLPALYHLIRKPKFESYILLILSPEQHLTYVHTYPGLRGHIDTEVGQATTPTLPCSVNFESRTQLGKLSVPLPEGQGLEDIVDQLKECCQEARETSMNHSEDSARLSGKAKLLQVLGLCEQTLRQGFSLLKERETTPDVTAKFYTVDLVRISKPQQGPILDLHMKSISVRMKNIADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6C8</accession>
    <name>D4D6C8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023190.1">
        <property type="nucleotide sequence ID" value="XM_003023144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6C8"/>
    <dbReference type="GeneID" id="9583210"/>
    <dbReference type="KEGG" id="tve:TRV_02653"/>
    <dbReference type="HOGENOM" id="CLU_943277_0_0_1"/>
    <dbReference type="OrthoDB" id="5296805at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="34007" checksum="9B81144E259E96B9" modified="2010-05-18" version="1">MAFECIKPEDNRLSSLDKEVYILVHKYQAIKTPRTVIHLSKTPGYRELFNHVFEYHIGLIKTRSQSFEDCQITVYDKALLILTNNGNSLSHFGAIELFKDEILGIRKDDDMGRLDALFSKNIALRAILGHVTGWRKETALDHALTDATTPVFGSRQTSHQQQGTSDPLTPPPSASIRELDQSLANMFIAFATAQLEHARIKSAKTAKLVGDSAENLLRHLRDHDPTHYMIPVLKQASRMAQREMGEVTRGKKRSLDMSDKGTVDYSARRSSSSGRCSTSVGKPRVSRRRRRGVRGQADCYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6I3</accession>
    <name>D4D6I3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000142">
        <property type="protein sequence ID" value="EFE42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023130.1">
        <property type="nucleotide sequence ID" value="XM_003023084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6I3"/>
    <dbReference type="GeneID" id="9583178"/>
    <dbReference type="KEGG" id="tve:TRV_02708"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="519" mass="56998" checksum="D9FAB5FE5895F712" modified="2010-05-18" version="1">MFNTGNIYVIAAVAVIGGGLFGFDISSMSAILGTDQYKCYFNQYGPGQCGGPRPAVQGGITASMAGGSWLGALISGFVSDHLGRKKAIMVGAIVWIIGSVITCASQNIAMLIVGRVINGLSVGICSAQVPVYISEVAPPTKRGRLVGCQQWAITWGILIMFYISYGCSFIKGPAAFRVPWGLQAIPAVLLFFGMIPLPESPRWLARKDRWEECHRVLTLVHGHGDPDSPFVQRELQEIKDICEFERANADVSYLELFKPNMINRTHIGVFTQIWSQLTGMNVMMYYITYVFGMAGLTGNTLLVSSSIQYVINVAMTVPALLWIDRWGRRLPLLVGAFFMMTFLFVNAGLLAARGRPAPPGGLNGIEAESWEITGAPSKAVIACSYLFVASFAPTWGPVSWIYPPELFPLRVRGKAVALATSSNWAFNFALGYFVPPAFVNIQWKTYLLFGIFCAAMFIHVFVMFPDTAGKTLEEVEYMFTDPNGVKYIGIPAWKTRSSFQHAARLERTGGEEKLNSHHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6R4</accession>
    <name>P20D1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable carboxypeptidase TRV_02791</fullName>
            <ecNumber>3.4.17.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidase M20 domain-containing protein TRV_02791</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TRV_02791</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-"/>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023101.1">
        <property type="nucleotide sequence ID" value="XM_003023055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6R4"/>
    <dbReference type="SMR" id="D4D6R4"/>
    <dbReference type="GeneID" id="9583121"/>
    <dbReference type="KEGG" id="tve:TRV_02791"/>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411241" description="Probable carboxypeptidase TRV_02791">
        <location>
            <begin position="23"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="460" mass="49832" checksum="0C81AD8143E4B83F" modified="2010-05-18" version="1" precursor="true">MQKTYLWALVSLLASSLVDARSAVFDQTPLDIGGSDDSFDSIARIDPNSNDLLKSEMDKVIASSELLSLHRALVEIKSISDNEQAVGGFLMDYLYSKNFTVEKQFVDYDDPTGKPIRTNRRFNIYAYPGNSASPGIILTSHIDTVPPFIPYSLSHPEPASFKREDILISGRGTVDDKASVACQVIAAMDHLEKHPDIPIGLLFVVSEEVGGRGMSTFSNSRLNSGTYHTIIFGEPTERALVAGHKGMVSFTIRVHGKPAHSGYPWLGRSAVSEMLPILTEVDRLGDIPVSQGGLPSSEKYGRTTLNIGFMSGGVAANVVAEEAVANVAVRLAAGDPEDAKDIIFRAIRNAATKHRKDATVVISNGLERPKGDIEVIFGLEAYGVVDIDADVDGFNVTTVNYGTDIPHWKIYGDNVKRYLYGPGTIFVAHGKNEALTVGELEAGLEGYKTLVAKAAERERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Z7</accession>
    <name>D4D6Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022970.1">
        <property type="nucleotide sequence ID" value="XM_003022924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Z7"/>
    <dbReference type="GeneID" id="9582989"/>
    <dbReference type="KEGG" id="tve:TRV_02875"/>
    <dbReference type="HOGENOM" id="CLU_760695_0_0_1"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="40849" checksum="3335EF80F5E48474" modified="2010-05-18" version="1">MFQQGSGYLAAAAAYPYSDTFDQDIIASRQALQSTARTISAEASSRLASMAHHSPEHTMLALSNRPEVHRNASISAAGLSRPAYSSPNTPFYHQQCAYQPASVPATTMAASSYFPKYQQTQFSQEQTVSSNYVYSSVDQSLSSYCQYQMTPDGYYDTYFPTSTMSMAYTQQQDVDMTSSTYDATPLSHAQHSLPAMESNTAFSTPDLPANQQFPEPKTPPPPTSSNSSCESVRDEDDLVGVGLYDEPLPTSYWDESLSSSVDPILYPYPTTRKGLKLEETLDPSTLNCSDMDADGDEEEEGDEQPQKEQPVKGSGEPSNANNLNTSKEGQLFTVDDDTSYSSAQVNWTSAPPVMLNSYAAFPGSYQNVFPTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7C8</accession>
    <name>D4D7C8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022848.1">
        <property type="nucleotide sequence ID" value="XM_003022802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7C8"/>
    <dbReference type="GeneID" id="9581587"/>
    <dbReference type="KEGG" id="tve:TRV_03010"/>
    <dbReference type="HOGENOM" id="CLU_090389_14_4_1"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="93" mass="9926" checksum="E88FB8377BA08E3A" modified="2010-05-18" version="1">MKAIGGDRLVLIDCYATWCGPCKAIAPVVDKLSEEHCAEVDFYKVDVDECSEVAAELGVRAMPTFFFFKGGEKLDSVAGAAEGPIVAALARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7I5</accession>
    <name>D4D7I5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022843.1">
        <property type="nucleotide sequence ID" value="XM_003022797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7I5"/>
    <dbReference type="GeneID" id="9581567"/>
    <dbReference type="KEGG" id="tve:TRV_03067"/>
    <dbReference type="HOGENOM" id="CLU_003774_2_0_1"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="142"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="788"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="978" mass="111304" checksum="03E7C410A05FD0A7" modified="2010-05-18" version="1">MPGLQLPRAAFEPISPDLDFTELVESTPNFEPVTRIPAHAIEEQGIENFEKLVKLHVIYSGKPLVVEGYGSKLEKWIFSPRWLKDNHGSKVEIARDLTNKSNVPLTIQHYLSSMAGLTDQFNATNYKDSSRQRMYLKDIDCPPVWHEKLRSLLPQFLYYMNESVTGKEGDAAPAGDLMSSLPEEMRAMNMMCYIGHEGTYTPAHREMCATLGHNIMVEASTGGLEDGKPTKPGSSIWFMTEKKDLKVVSEYWLSTLGHDIEIEDHFAQINAWKSAPFKTWVVEQKVGDFILIPPLAPHQVWNRGTRTMKVAWNRTTAETLDLALTEALPRARMVCRDEQYKNKAIIYFSLKKYSSLLEKSTTRDDLRYRSLKSDFKRLFASFTQILLSESFSTRIPEPKNVELVPFSSNITCSYCRCNIFNRFLTCPSCIGKFPDGEDDTYDVCMDCFVMGRSCACISKLRWVEQFRWKDLTRDHERWRNQIAKFSSGKSRKDKDNFQPLSVEQEKYEKKTLAEICQVELKRRPWTDITKPVKDDVDDDDENHRESTRKRRKITKADKHKYSRCHICGPTLNWKLETCSQCNLQWCYGSLYRAFDIMPMTVLEVRSWKCPRCERICPCANCKRRDPTIEGYIPTETRIGHDTKKIADVRSVESLVDFSHSNLFWLKKSGEHPETSQNSRRMQLRIEEAEKAKLDEPVLYNHDSDGSEIRGAEEQNNNSNFDESLIDPALMDRGHQTSFVVPQNAIFRDEVADRYQPTEGITFEYPEPEQPAEQNKAEEIVVDPNLFQTNGQAPEEVNGGEPDEDEPEDLPVDPSLDDGAGSRRKRGIEIDDDFTLSRRSISRINTSGARKVATRRSQLNPIQSDDLGGSGSDQSEGEDRAEEQTSQAMLRPRTSRPAKKTVKKSAATKASKSKTAKNASEAVETKVTGESIPTAQLQNKSPLGPTSEVNGTAKQAAKNKTAKLQAMGWVEDDDSDGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7M2</accession>
    <name>D4D7M2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol:H+ symporter (Gup1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000160">
        <property type="protein sequence ID" value="EFE42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022771.1">
        <property type="nucleotide sequence ID" value="XM_003022725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7M2"/>
    <dbReference type="GeneID" id="9581461"/>
    <dbReference type="KEGG" id="tve:TRV_03105"/>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73648" checksum="D40C37B18D34380A" modified="2010-05-18" version="1">MGVIRWLRRLYSLDTLDTRFTVSSTTPIKAVTTSSHDAAPGSSSSDADGKRLESVKAGAPPSRWNTVEFYFYYLAFLTIVPLMFKAVIDISQPTHPTYSSYSKLLDPGWIPGRKVDNSDSQYSTFRDNIPYMTLLLVFHPCLRRVYEHLSPAKISTAPPTGGKAKDDDKPEGCAADAEARLKQRVTFDYVFGIVLILVLHGVSAFKILAILWINYLIATRLQRAQIPAATWIFNIGILFSNELLHGYPLVDLAKIVSPNTDSSFITWAKWVDGIGGIVPRWEVLFKITVLRLISFNMDYYWSLDYRFGSPVETKMTDSPKKKQVDPSALSERDRVSMPAPPSTYNLQNYVAYILYSPLYLAGPILTFNDYINQQHYSPASLTRSRTVLYGVRFLLTLLSMELVLHYIYVVAISKSSPDWSAYTPFQLSMLGYFNLHIIWLKLLIPWRFFRLWALVDGIDPPENMVRCMSNNYSALAFWRGWHRSFNRWVVRYMYIPLGGGGRARSGTSSPSDSKPSILSKARGVMNFLAVFTFVAIWHDINLRLLMWGWLITLFVLPEVICTILFPAKKWQSHPNAYRVLCGIGAVGNILPMMAANLVGFAVGLDGLKGLIHGIVGSYFGLAFLAAACATLFVGVQVMFEVRGSELRAGIRLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7U6</accession>
    <name>D4D7U6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy protein Apg16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022719.1">
        <property type="nucleotide sequence ID" value="XM_003022673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7U6"/>
    <dbReference type="GeneID" id="9581408"/>
    <dbReference type="KEGG" id="tve:TRV_03180"/>
    <dbReference type="HOGENOM" id="CLU_082752_0_0_1"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="202" mass="23094" checksum="63B829B81338D80A" modified="2010-05-18" version="1">MSSWRQDYSAALRIRDQQEKAYVSVLEASDRSGSLEKERAEAVRYAQNLSGSKENDTPQDKKYQSPHDSPAVIPGLDPLLTANQDLAAAQKAREELSNKLEKATGKIDTLLRKLNTESQRVADLAVERTQLQIRLRDRDEELRGKAKLLDDVQDELVTLNLQFNMAEERAKRFEEENQQLVDRWMARMGQEAEAMNKASRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8G9</accession>
    <name>D4D8G9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA export factor Mlo3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022455.1">
        <property type="nucleotide sequence ID" value="XM_003022409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8G9"/>
    <dbReference type="GeneID" id="9581002"/>
    <dbReference type="KEGG" id="tve:TRV_03405"/>
    <dbReference type="HOGENOM" id="CLU_158071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="73" mass="7603" checksum="3B01EF0DA4AB9836" modified="2010-05-18" version="1">MSEKLDKALDELVSSRRQARRQRRPAAKAAKAAPVGGVRKSTRQPKPTSKATPTAPAAGSGDGKIIVSGLVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8H4</accession>
    <name>D4D8H4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022460.1">
        <property type="nucleotide sequence ID" value="XM_003022414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8H4"/>
    <dbReference type="GeneID" id="9581007"/>
    <dbReference type="KEGG" id="tve:TRV_03410"/>
    <dbReference type="HOGENOM" id="CLU_000604_45_1_1"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="403"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="725" mass="81645" checksum="5A94BC965FE126DD" modified="2010-05-18" version="1">MLKPLLCRQWPIPGYPAASARRFSTQTSQPIIKIKDATFFRHYPIPGDSQKENPPLYPNLSFELLPVDNEASRSDRARNSQKHPFWAVIGSSDRSVFLEILCGRHICIPPAARSYPLLATEEITLKDPRLRFPGRAIRYIGLNGDAKKDAGGVRGSYLSARYESRKEETDFTVLQFLRGQTSLNPLEGTEDIPYTHGKLLHQVVADLGLQKLLDMPLSNLSNGQTRRARIAKALLDKPEVLLLDDPFMGLDPPTVKALSPLLFNISLRGSPQVILSLRPQDTLPDWITHVVILNKDHTVALQGEKCDVLNHLEIWKAVAHRKLNPMSGREQLLPRNKDEEKQYTAFSAQDRLKYDQAEMLFKEHRFESETALLHDLEIMSKPPDFGLKRTKNYGEPIVEMEGVRVLYGEKTVLGGWDQTIEGKKKEGLYWEVRRGQRWGVFGLNGSGKTTLLSLITSDHPQAYSLPLRLFGRSRLPEAGKPGISLFDLQSRIGHSSPEVHAFFPRSLSIRASVESAWADTFLSKPKLDQKRRLDVISALKFFEADLNAEFLLGANHEAHDPSVSWADNTLFSSLDVAQQRLVLFLRAVVNKPELIVLDEAFSGMPRSLRDKCLHFLEAGETLEESTGSRRVPDFNMWHLPRLQSHAMNEARHRGLSASQALIVISHVKEEVPDVVSHWMRLPTGSENDRGLVGRASTGTSSNSFRIGTLKDNQTIPGDAWDEIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I1</accession>
    <name>D4D8I1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022467.1">
        <property type="nucleotide sequence ID" value="XM_003022421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8I1"/>
    <dbReference type="GeneID" id="9581014"/>
    <dbReference type="KEGG" id="tve:TRV_03417"/>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="376" mass="42386" checksum="9C3D7379661761FA" modified="2010-05-18" version="1">MPPRKGDQPKKAKPSVQDKVYHFLNFGSASIPSPLLTGADAVKKKGSTARKQIAQLEAQAASNKSADAKRKAMEKEKREKEKAAAEQAKREVAELFKPVQVQKVPFGVDPKTVLCVFFKKGNCEKGRKCKFSHDLAVERKAEKKNIYQDTRDEQDPKKADTMDNWDEQKLRDVVLSKHGNPRTTTDKVCKYFIEAVENQKYGWFWTCPNGGDKCMYKHSLPPGFVLKTKEQRAAEKALLDKSPLKTLTLEDFLETERHKLTGKLTPVTEESFAKWKKERLDKKAAEDEARKAKEATGRAMFESGEWRNQESEAESSDDDDEGDGDAWNLESMRKETEALRDKSEQERVAKLQGSTDAPEDTAVSSREPPATVEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8N5</accession>
    <name>D4D8N5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022408.1">
        <property type="nucleotide sequence ID" value="XM_003022362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8N5"/>
    <dbReference type="GeneID" id="9580955"/>
    <dbReference type="KEGG" id="tve:TRV_03472"/>
    <dbReference type="HOGENOM" id="CLU_506222_0_0_1"/>
    <dbReference type="OrthoDB" id="5416940at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="58270" checksum="6C2B77DEE86A14E9" modified="2010-05-18" version="1">MTDWIVALGRFNNTIIFAICERQIVDILDPAVGVLAFMTSPLLGRILLTKSRSTAAINIAALHVLSSVNQGLDELTQPMGYTRLQRHLMIGEAIAANLKNATIKSTYEGVNLGHHRLLCSSMIAENHSPQDSVFASIDRIYNLFCGAIITGNISLVQSMAASVDVNALNVFFGRPLGLAAVWGHLDIVRYLLDHGADPHIIAERWERWDNDILTINNGVYEHEYRCPGGSALSAAALGGNKEIVSLLLEPEFRLSPSSSEYHRAILCAVRIGRTDIVDMFLEVQGISIYDLKHFKDLMLWEAVCHNRESMVQLLVDNSADINRDGPLIREHGCALHLAAQNGYDNLIRLLLDQGADISYVSSYKSLTPMGFAARGGHLEAVQVLVEYGEKLEHALVPAASTGQSHMVKWLVEKGVDLNYCHYDENIGIQALVQAIMVKNLGIISILAAAGVPLNNDDSDLSRDPVWVAKSLSSPWVFEFLLSIGAQDREYSEDQLIDKREERMYELGRYGLLDVNQETWMWQGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W3</accession>
    <name>D4D8W3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_03551</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022340.1">
        <property type="nucleotide sequence ID" value="XM_003022294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8W3"/>
    <dbReference type="GeneID" id="9580887"/>
    <dbReference type="KEGG" id="tve:TRV_03551"/>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="204"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="43075" checksum="EDBAA592981CEC42" modified="2010-05-18" version="1">MAATNDQRVYRASSTAPVNIAVIKYWGKRDATLNLPTNSSLSVTLSQSSLRAYTTASCSSKYPTADGDSLTLNNKPHSIQGSPRTLACLADLRSLRQQIESSDPSLPKLSTYPLRIVSENNFPTAAGLASSAAGFAALVRAVADLYQLPQSASELSKIARKGSGSACRSLMGGYVAWRAGEKEDGSDSIAEQVAPESHWPEMRALILVVSGAQKEVPSTEGMQLTVATSTLFPSRAQSIVPERMTAIEKSIQERNFETFAEITMRDSNGFHATNLDTWPPTFYLNDTSRAAIRAVHDINRAAGRSVCAYTFDAGPNAVIYYLEKDADCVLGTFKSILTSATEGWESADIKNTNLLEKSIDPRAAELLSKGVGRVFLTGVGGGPISKKEHLVSESGEILTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D971</accession>
    <name>D4D971_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000187">
        <property type="protein sequence ID" value="EFE41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022210.1">
        <property type="nucleotide sequence ID" value="XM_003022164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D971"/>
    <dbReference type="GeneID" id="9579105"/>
    <dbReference type="KEGG" id="tve:TRV_03661"/>
    <dbReference type="HOGENOM" id="CLU_946553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="255" mass="27190" checksum="10B57ECC8AD612E1" modified="2010-05-18" version="1" fragment="single">MRDPVLAAAAGADHSEKPAVAAVAVAVAAAVVVAAAGVTGALEEEQRRLAKKIEWKANSGRTLRRRKGQQQRSTKEKERQRERERGYTQKHRLGARTAGPSGLHGEAAGQHPDATHLYPTDSYGATRRAAGPQPTTGVNETGRRAQREQDSRCRPGTPSTGNAARPATGRKSLNWASSKRVEGGSLSGASCGAGHGTRPPESSAGKAAGWSGNRWSKRKIVFAFSLDLSFATEKLQKKKKKGRKKDPKLDEKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9I9</accession>
    <name>D4D9I9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000195">
        <property type="protein sequence ID" value="EFE41477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022095.1">
        <property type="nucleotide sequence ID" value="XM_003022049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9I9"/>
    <dbReference type="GeneID" id="9578979"/>
    <dbReference type="KEGG" id="tve:TRV_03782"/>
    <dbReference type="HOGENOM" id="CLU_092840_0_0_1"/>
    <dbReference type="OrthoDB" id="4173674at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="15828" checksum="C50983FFF644737E" modified="2010-05-18" version="1">MSMTSSTFTTSRTSSPSTSSATSSSVPVPAHTGLSGAQIGGVAAGCAVFALLILLGATYFFRRRKASEPQGEKPDTSDSGISEMPDSAGVAPRGPKAAVVLGELDSKEANELDSKEAKIDKSAAVNRARELDSTPISSPVELDSSPIEPKETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9L6</accession>
    <name>D4D9L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022068.1">
        <property type="nucleotide sequence ID" value="XM_003022022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9L6"/>
    <dbReference type="GeneID" id="9578952"/>
    <dbReference type="KEGG" id="tve:TRV_03809"/>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="433"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="628"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="742"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="847"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="968" mass="109042" checksum="644F8635FC79C0FE" modified="2010-05-18" version="1">MATDRRNQEEEGYEFVVVSGYVRRSSGWWLAVSVCLFCRFRPVASPRPFYSFVFLFPFGDERLTERVWCTDVFFFSLFSLGGTDYIIQAHSPPLAEKKSHEKRRKKKKDFLTMQESKEKKQHPGLCVLLVFCSTCQPPRENKMEGTRVFVSGLPPSLTSDKLRNHFAQRFEVTDAHVIPNRRIGFVGFKGPDLAENAVKYFNKTFINMSKISVEMARPVSLEGLNGRKLTASFSKVDADNSDDLRARYRKHLNAKKDPPSLKRKRDTQDTEEDEKLQEYLTAMQPPTKSRTWADSGAIPTAHQEQKPATDAAKEPTEGEDDVEMHNVETAVTDIPVTEQEAKSDDVDAVNVNENPVQQNDDDWLRSKTSRLLGLLDDEDEMAAETWKGKPLENATDQPPVPAKIPSTKAAVEEGESVPEPPPDANIESIRLTGRLFIRNLPYNASEDDLNATFSRFGKIEEEEYFSRCLFNLMTVSFLIAAINYCKGFAYIQYVESDAAIEAYKQLDGKDFQGRLMHILPASSKKTYKLDEFEISKLPLKKQQQIKRKAEAASSTFSWNSLYMNTDAVMASVADRLGVSKSQLLDPTSSDAAVKQAHAETHVIQETKAYFSANGVNIESFKQRERGNTALLLKNFTYGVSSEDIRKLCEPFGQLTRLLMPPSGTIAIVEFAMPDEALRAFKGLAYKRIGDSILYVEKAPKNLFEGGPPVTMPSLLNQKVVSQGFSTSDTFKADEPEAPMESATLFVRNLNFITTDAGLSDLFRPLDGFISAQVKTRPDPKKPGERLSMGFGFVEFKSRAQAEAALKALNGYKLDQHELVIKPSHKGMDAAEQRRREDNAKKASAKRTKIIIKNLPFQATKKDIWSLFAAYGQLRSVRVPKKFDRTARGFAFADFVSSREAENAMDALRNTHLLGRRLVLEFVSEEATDPEDQIKEIEKKVDAQVNKVKIQKLMGPGRKKFHVDADLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA26</accession>
    <name>D4DA26_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021940.1">
        <property type="nucleotide sequence ID" value="XM_003021894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA26"/>
    <dbReference type="GeneID" id="9578823"/>
    <dbReference type="KEGG" id="tve:TRV_03970"/>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="243" mass="26188" checksum="FDE75CD91216C499" modified="2010-05-18" version="1">MTSLQHPPLSYEASATTTHPHFATCLPQEVVSCLKNSRFLHLATCDGLNPHISLMSYTFLPSTPFNPTPTIIMTTNPSSKKTLNLRSNPRVSLLVHDWVSHRPPTRTRDAGREGSPPPAATQSSLATLLLNLNTSAMSSISTTIIGEARVLDVGSEEEKWCRERHLESNTFIADEGGIGVFSSSGQAQQGSTGEQERRPSIMDDDVNVVVVAVKEGRIADLKGGVRDWAVVTEGQMNGVAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA93</accession>
    <name>D4DA93_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_04039</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021862.1">
        <property type="nucleotide sequence ID" value="XM_003021816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA93"/>
    <dbReference type="GeneID" id="9578744"/>
    <dbReference type="KEGG" id="tve:TRV_04039"/>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="354"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="452"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE41244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="708" mass="79217" checksum="8B424FA0B67A9BF9" modified="2010-05-18" version="1">MVRKSKGFNWGAAGLSTALFTGPMMHDILTRAKPDRRAKYMCMEGADALPNGNYGTSIRLSTAMDPAMGVMLAYMMNGEPLRQDHGWPLRAVIPGHIGGRSVKWITRIILTENPSDNWYHIYDNRVLPTMCSPEMATEDDSWWRDERYVIQHLNVNSAIAYPQHDEEVVMSTTPTYTIKGYAYGGGGRQVSRIEVSLDSGKTWRLSNIKYDEDKYRATSQYLYGGQLDLSWRETYFCWCFWSLEVQTHELESADSIVVRAMDEALNIQPREMYWSVLGMMNNPWFRITISKENGVLKFKHPTLPATQPGGWMEQVKKAGGDLTDGNWGEAPNGAVKRVEVAPEPEINMKKPGLKVNITLEEFKEHNSRETDPWFVVEGEVYDGTPFLEGHPGGAQSIISTAATDCTDEFLAIHSESAKAMMPDYHIGTLDPAALRELQSSQGESNKPLPVIHEWEKVKLTKKKVLSLDTALFTFSFADTSKVLGIGVGQHIMLKVNTRSNDPSSGVIRAITPLSDPSLKGSMELLIKIYRPAPGFAGGQLTVPLDKLPIGAEVDYRLSSHCKFEYLGRGRVTIDGKERNISSFNMICGGSGITPMFQVLRAVLQDAEDTTTCTLLDGNRTEDDIMCRSELASFVSCDTKNKLKVVHTLTQASESWCGYRGRISKDLISRHVARSKNSMVLICGPASLETSVKKMLLEQHWDEEDIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAB7</accession>
    <name>D4DAB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_04064</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000206">
        <property type="protein sequence ID" value="EFE41198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021816.1">
        <property type="nucleotide sequence ID" value="XM_003021770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAB7"/>
    <dbReference type="GeneID" id="9578700"/>
    <dbReference type="KEGG" id="tve:TRV_04064"/>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="81"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE41198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="479" mass="53589" checksum="76997895D8ECE8FC" modified="2010-05-18" version="1">MTSANFAAAQERVLERRRQRELEARNRLANRTSRLPAAASNLPYPLSSLPTRGLALWDILRGREGTRPAFRVGQVDAELLDEELITLLKGQVGEGLKDFGRHIRDDWNHEIDLVLRAILFKLSVWDHNASYGAALQNLKYTDSRSKGPVHSDPTKLQKSLYGLLTVGGRYAWDKWESWIIHQGGGYDEPQSSNTRALSKLTSLLSTAHSIAAFASFLIFLVNGRYRTLVDRLLYMRLTPPSMQVSREVSFEYLNRQLVWHAFTEFLLFLLPLVGIGRWRRWVSRAWRKTMSSLRATGDENKEKNQGELGFLPERTCPICYQAQNPTTISESDVMGPGAASGGIIGSAQTDTTNPYETVPCQCLYCFTCIAQKLEGEEGEAWTCLRCGELVKQCKPWNGDVLEEPQPQPQSTAAAATAVRKNVEFAVTDSHIESSDTVDDSDSAARVDIDDGMNETSPWAAVGVEETDDTSVHTDLDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA1</accession>
    <name>D4DBA1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_04400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021553.1">
        <property type="nucleotide sequence ID" value="XM_003021507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA1"/>
    <dbReference type="GeneID" id="9578514"/>
    <dbReference type="KEGG" id="tve:TRV_04400"/>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE40935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="449" mass="47728" checksum="8310B35919D9B4A2" modified="2010-05-18" version="1">MSGMRDEDKTEVRERKGRGASEYKSPSMPANSLSSSQRSISPLYTLLVALLSLAVALLALRTTVSTTSVSILLPAFSPLRLSRHYSNTAMSSTPSYRQELRVAELAVQRASLLTQKVSQLKAKGTLSKDDTSPVTIGDFGAQALIIQAIKKNFPDDEIVAEEEASSLRENKALSSQIWELVKETRLNDTESDWLVGGQMASEEVFLDTLDSGKSAGGPKGRIWALDPIDGTKGFLRGEQYAVCLGLIVDGDLKVGAIGCPNLPVSDAALTPTVGQSGSEGIETGVLFGTIKGAGSTSRKLGDGALLPSKPISMRPVPNIADACFCESVESGHSAQGDNAEVARLLGITNQSIRLDSQAKYCSIARGAGDIYLRLPTRPDYQEKIWDHAAGDLLVREAGGQVTDIHGKRLDFSIGRTLKENKGVVAAPATIHAQVIEAVTAMYAAKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS9</accession>
    <name>D4DBS9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000231">
        <property type="protein sequence ID" value="EFE40686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021304.1">
        <property type="nucleotide sequence ID" value="XM_003021258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS9"/>
    <dbReference type="GeneID" id="9578157"/>
    <dbReference type="KEGG" id="tve:TRV_04580"/>
    <dbReference type="HOGENOM" id="CLU_1870154_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="137" mass="15816" checksum="BD1A7406881F5FCE" modified="2010-05-18" version="1" fragment="single">KIRIVLRRLEGARKEQIVVPGEIPRAFYPVIKVGGGRVKKANPPPPAIGQDRIISKYPDKAEKQLQKINASEKYNYSRTKFKKDTKFKDREPRTRSKDPAKVGLQKREGKNVAIQVIKKNDWDGFFEDYHSFFSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBW5</accession>
    <name>D4DBW5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021303.1">
        <property type="nucleotide sequence ID" value="XM_003021257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBW5"/>
    <dbReference type="GeneID" id="9578148"/>
    <dbReference type="KEGG" id="tve:TRV_04616"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="208"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="49361" checksum="E61828581BBB96E9" modified="2010-05-18" version="1">MPATTMQQTNGGTPKTNGTHSQESMLEVLASQVQENAKVVSEFLRTSGHAAPSFASDAPATSLPASAPPEIGAARQALMGAALQIFHLAAGPSEYLPHLAVGYQHIACLRWLTHFNIFKLVPRDSSISYPALAAAAGVSVKQLKTVARMAMTNHLFCEPESNMVAHTAASMLIATDSSFYDWASFMCEASVPMAAKLVEATVKWTDSEEKTQTAYNVAFDTDLPFFDHLKTQPDKTRQFASYMKNVQKSGGTGMHYLIEGFDWASLGKGTVVDVGGSSGAASISLASTFPDLNFIVQDLPENAADGQAFLASPEQQEKLGKGVTSRIFFEGHDFFQPQPFQGADVYLLRMILHDWPKKEAVKILQNILPALKGSSRIIIMDTVLPQPGSIPSAQERLLRARDMTMLEAFNSLERDLEDWKELLHSVDERLTLKNVVQPVGSVMSVLEITLGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC66</accession>
    <name>D4DC66_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000237">
        <property type="protein sequence ID" value="EFE40552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021170.1">
        <property type="nucleotide sequence ID" value="XM_003021124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC66"/>
    <dbReference type="GeneID" id="9578013"/>
    <dbReference type="KEGG" id="tve:TRV_04718"/>
    <dbReference type="HOGENOM" id="CLU_004083_9_2_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="524" mass="59731" checksum="8CD92FC21B77FD71" modified="2010-05-18" version="1">MLLGDHVQGTSTESPSPLEQMIEPFPFSTEVPSDSLAPWAPKTAEECFTLLDIFYSNVDPMTRLVHKPSLRKRFLQYTMEIYGPNSQTSTDNGTTQTPYPAIHTFEPLALAIFYSAINSLSSEAVQSRFATEKGPLLARFQRGVEYGLGREDFLTTPRIEVLQAFVLLLVEIRRRLWHQICYLDFRSAEGRGQEPTIADEDYTTLLPRNINDDDLVEGEPLVAGTYSPPGFTDMTGHLIRLNGIHCFRRIIRSTYRLERRLKSLGINGNNDIYPITELQSLFIEIRNMVDEMTAHLQTQYLQYCDPNVANQRLALGLAAVIEWRCWSIFWLRTPKQYREAVVDPEIRETVLTKSISLVESMNMMPDDKDAEKFQWHIGGHACFQAIMHIVSELGTPEFQTTTHHSLRSRALAVLKKTTDARGSEHSSTWNVINRIISNCLAKNTPSILPSTPLNDTYYIYQESVDLSQSLQESRRVSEDPTTQGLSLSSSFGMGSLDMQDPSLTFDWVSDIVLELYYYFPNIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCA6</accession>
    <name>D4DCA6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_04759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021144.1">
        <property type="nucleotide sequence ID" value="XM_003021098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCA6"/>
    <dbReference type="GeneID" id="9577987"/>
    <dbReference type="KEGG" id="tve:TRV_04759"/>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="306"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="436" mass="47791" checksum="14D179C56C84C3B7" modified="2010-05-18" version="1">MLAVPSASSNMASTKAVILVGGPSRGTRFRPLSLDMPKPLFEVAGHPIILHCLKAVAKVPGIREVILVGYYDETVFRDFIKSASVEFPQFRIQYLREYQALGTAGGLYHFRDAILKGRPERFFVLNADVCCSFPLGEMLKLFEEKDAEAVILGTRVSDDAATNFGCIVSDTHTKRVLHYVEKPESHISNLINCGVYLFATECIFPSIRSAIKRRTARPRLLSYPSSENLESSYVAQDDSAEMPEVLRLEQDILPDLADSNRFFVHETKDFWRQIKTAGSAVPANALYLQKAFQSGSEELAAPSASIVPPVYIHPSATVDPTAKLGPNVSIGARAVVGPGVRIKESIVLEDAEIKHDACILYSIIGWSSRVGAWARVEGTPTPAGSHSTTIIKNGVKVQNITILGKECGVGDEVRVQNCVCLPFKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCF3</accession>
    <name>D4DCF3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021093.1">
        <property type="nucleotide sequence ID" value="XM_003021047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCF3"/>
    <dbReference type="GeneID" id="9576734"/>
    <dbReference type="KEGG" id="tve:TRV_04806"/>
    <dbReference type="HOGENOM" id="CLU_2028409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="122" mass="13837" checksum="B9A17B59AEA14870" modified="2010-05-18" version="1">MGRKRETPGRTPVTLEVGEEIGDELAISNDGDVGRRRKGGRKEDEEEFITKSRRWGSKKADEGQQKTKRIIGREQAGPDLRLRNVAKGSKGLHLKKYLEDAEEVKLYWQIGYSKGALLRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI9</accession>
    <name>D4DCI9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_04844</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020979.1">
        <property type="nucleotide sequence ID" value="XM_003020933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCI9"/>
    <dbReference type="GeneID" id="9577831"/>
    <dbReference type="KEGG" id="tve:TRV_04844"/>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="205"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="657" mass="70830" checksum="34EED9EE7BA35A78" modified="2010-05-18" version="1">MESLLQQSRALCPFLKKTAPATLRALSTTTRPSSSVVGGTITNLQVVARRCPVMGKALAVQSARIALRSGEARAFGTCPRSAGAAGLVRENLHRAHGKALCPVSKKGLHTTAAQAAVVDQQAREKGRAVPVPPRATVEQLNCARETFAGPKPAIPSATAKFDYEGFYRGELDKKLKDKSYRYFNNINRLAKEFPRAHMASPEDRVTVWCANDYLGMGRNPHVLKSMHDTLDNYGAGAGGTRNISGHNQHAVALEKTVADLHRKEAALVFSSCYVANDATLATLGSKLPDCVILSDSLNHASMIQGIRHSGAKKYVFKHNDLEDLEMKLAALPPGIPKIIAFESVYSMCGSVAPIEAICDLAEKYGAITFLDEVHAVGMYGPHGAGVAEHLDYEAYANAEADIRGTVMDRIDIITGTLGKAYGCVGGYIAGSADLVDTIRSLAPGFIFTTSLPPATMAGATTSIEYQSSYTRDRTMQQLHTRAVKSALDANDIPVIPNPSHIVPILVGDAEVAKKASDMLLEDYGVYVQAINYPTVPRGEERLRVTPTPGHTKEYRDHLVEALKGVWERLGIRKTSDWKAAGGFLGVGSAHEEKNVPLWTDEQLGLAAGEKLEAAIERELKAEAAHREQMIRELAGECAAEAKESQFQHTNQPISASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL3</accession>
    <name>D4DCL3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04868</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021003.1">
        <property type="nucleotide sequence ID" value="XM_003020957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL3"/>
    <dbReference type="GeneID" id="9577855"/>
    <dbReference type="KEGG" id="tve:TRV_04868"/>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="83"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="536"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="634"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE40385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="785" mass="85914" checksum="706F15542999E57A" modified="2010-05-18" version="1">MAANFLGGVILKVLRKREEEEDPDDSPEAGEREFWTSWALFILIVLLITALFTSYLLKQKRIQAVHETVLSIFGDVIGMLTQLLGMVVGLVIRFTPGTLIQKSVSFDYQFFFNLLLPPIILASGYELHQGNFFRNIGSILTFAFAGTFISALVLGLVLFLWTRIPIEGLDISFVEAFSVGATLSATDPVTILAIFNVYKVEPKLYTVIFGESILNDAIAIVLFETAQRYKPGSAAGSLTVLSLFEAIGIFLIVFFGSLLIGVIFGIGTALGLKYTHVRRDPKIESCLILLIAYACYFFSTGIKMSDLLSFTDVSVPGIVSLLFCGMTLKHYAYYNMSRRTQLTTKYIFQTMAQLSENFIFIYLGLDLFTDENLQFKPLSIMVSVVGICVARYLSVFPLSQAINWVIRYRAASRGRDVADELPYPYQAMLFWAGLRGAVGVALAAGLEGTNAPALRATVLVVVVLTVIIFGGTTARMLEILDIRTGVVEEIDSDDEFDIEVTNGGTYYKRSGTGMGHTPRRSDFQLDSVAREHEINRTGHGFSSGSNGRLTPQAPEGPGGLTRKKSSYSRIDRTRSRDGASTQELLGGRSGSHSGSSVDIDMSHDRSRAGRNARGTGDMGMNLDDFDLEVDAAFSDDDLPPAASQAQRSRNHSQPRSASAHTPGDGPYANTAQAETSSSSRPIAAATDAFRDLLSGNRDHATWFKHLDDEYIKPKLLLDQGSGSGSPSGSGRKGPDAIFHVLLAFCYGVAGPNNILINYRAFIISFINIVPIRNYTVSFSRLPTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCP5</accession>
    <name>D4DCP5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021035.1">
        <property type="nucleotide sequence ID" value="XM_003020989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCP5"/>
    <dbReference type="GeneID" id="9576682"/>
    <dbReference type="KEGG" id="tve:TRV_04900"/>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="368" mass="41784" checksum="5BFE46B885CFA282" modified="2010-05-18" version="1">MSTQFALSKHWKEYDVFAQQKMSTFRSSRPAVLELATRYRDLSQDLKQIHSKRDDMTPEQQQEADKVLFMEMCEICLWGNATDLSLLTSLTYEDIQKLQGAEARKKAEANVLVNDLPAAFELLNKARTERKNEERRVDIVLDNAGFELFVDLILAGYLLSSGLATCVVLHPKSIPWFVSDVLPRDFGDLIALLSDPQSFFSSTGEEETGEEKKPQPLTDKEVDELKYLFQQWGDFHAEGQLIIRPNRFWTTASSYWRLPHEAPSLYEDLKESELVIFKGDLNYRKLTADAHWDPTTPFDTAIGPLGQGSGVRVLALRTCKADVVVGLEKGEDERLRNMPNGGGDSGSRKWAWSGKWAVVSLCDRKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCW3</accession>
    <name>D4DCW3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020893.1">
        <property type="nucleotide sequence ID" value="XM_003020847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCW3"/>
    <dbReference type="GeneID" id="9577745"/>
    <dbReference type="KEGG" id="tve:TRV_04969"/>
    <dbReference type="HOGENOM" id="CLU_025201_0_0_1"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="381"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="561" mass="60417" checksum="18FE49BEED70F7B3" modified="2010-05-18" version="1">MGDQQNISQILAALAAVRPAAGAQYASPTGATPSTAPPPSTNTGGYSLPQPDNTGSLNIGGATSINAGSVSIADAIAKARGIAAEKGITYKPTPAQTRDAGRSSHRRSRSPSRTPPRNSTARDVFRDGYNPYRDERRGADRRGAGDRGYGRERSSSPRPGAYSPPSNRHYRAGGDRSPPPRNRGPVSDENNETIEIDNKHVGLIIGRQGENLRRIENETGARVQFLDSAEHNKTIRLCRLSGPKSIRDKAKAEIDRIVSENNQARNDGRPIGQDGRPVDADGSETTKIMVPDRTVGLVIGRSGETVRDLAERSGCRINIARDGESINGLRPVTLTGSQQAIQRAKELILGIVESDTRTSGNQGQREPRGQGSGGENGGGGEKLNDKMFIPKEYVGMVIGKGGEAIRELQTLSGCKINILPLVAREPEREVTFYGVQTAIDAAKKAVLAKVEAAKNRSQGPRRDDSYSQQSQYQQQQQPYSQDSNSQQQPQQQQQGMQAGVGDGTDPYAMYGGYENYMAMWYAALAQQQQQQQQQQQQYPQYQGGGAPPQSGSDQQGPPGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCW4</accession>
    <name>D4DCW4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020894.1">
        <property type="nucleotide sequence ID" value="XM_003020848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCW4"/>
    <dbReference type="GeneID" id="9577746"/>
    <dbReference type="KEGG" id="tve:TRV_04970"/>
    <dbReference type="HOGENOM" id="CLU_039967_0_0_1"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="320" mass="36225" checksum="D243F6DA27C8C8C0" modified="2010-05-18" version="1">MSSKSHPFSFGIEMELYLKPKSTSLKQRLQKLGFKPNDMDKTNQQLIFRKAMADEFTQNNILTRTEKSSVYDRWTIAHEAALDDIGGGYLLLRSCDVHLTKGCATHVHVAPAGGKYTLSQVKNIVKGTIYYESPVMRIMHEDRKENPWAQPNANIIPGCMTKIKNVSQGGWSPIFDEFKDHKFVATIVTAVCPDRNVSWNFQNLTDSGTMEFRRPRGVDNPDAAKHWIAFTVGFMANVIREENWDAISHTKTHPSTDRLRAVVVRGATSINLPVHSFLVPALMADNNKAATVLTKEERAIIRQKMAKKKNKRSLFVEKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCX4</accession>
    <name>D4DCX4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020904.1">
        <property type="nucleotide sequence ID" value="XM_003020858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577725"/>
    <dbReference type="KEGG" id="tve:TRV_04980"/>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1234"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3633"/>
            <end position="3969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1173"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1507"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1553"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1928"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2004"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2283"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2821"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2962"/>
            <end position="2989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3033"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3257"/>
            <end position="3337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1563"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1942"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1959"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2029"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2042"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2296"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2307"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2331"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2392"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2447"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2821"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2869"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2962"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3257"/>
            <end position="3275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3276"/>
            <end position="3294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3302"/>
            <end position="3313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3321"/>
            <end position="3331"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3969" mass="443220" checksum="39A3F702C18C462B" modified="2010-05-18" version="1">MGRIEKVASSKHEATISPAIAQYSKKAIEISVAELPSYLATFPRQWPFPRGDLYHWIGVLNRFDELLARVVTKYGLDEGPQSKPFGRLVLVEDSVSTSLVSNDEEGERKLDQLGLGPEGDRELVESILDFSRLLLEKCGNRSLFSSSERLNAFLNSTSLSLIQCTLRLSLCLAQRYYFRQRSTSSTHFHQSLLAAHYNIELDRVQKLASPFPRPPSFIETAEGTSLEKGKDKSAQPSAVAGDKCNANDLISLTKVPSDKITMTDISPAAEIGTAEWKDWGTVRFAYYPRDATVETSGGTLNTSSQVQMTPTPLRHRSSEYQSSRLLHTSSVDDSPTPTTQSPATRQEATRGMKILEIPNSKVLSTSTEELLKENLGDLPKESAYDLLNRLRIAAALAKSPETRRQLLGIRLLALSNLAYIYPEAIFQQKILQQDSDEPKRLQLAYQLSDFVHLGVAGDISASTLNQSFALTCLDALAKHKTRSADVCAALNLNVNHGILMFLVRKTVTELAAEDGLVDDIEGDDWRDALFGLLRTLPSSGTRAPETLMPAGLIPMFVDMLNLRTEKARRVYPRVLEFLDNYVHSVRDALATLATAKGFDAISDLIATETKSAFDMVGEGKGISEEFKTPSTDYSIPYFQQQAIRWLFKFVNHVMQHNSGGFERLIRNFIDSPPLLSALRLVIENAKTFGSHVWSGSINIMSHFIHNEPTSYAVIAEAGLSKSFLEAVMCKPLEVPEESAEGDKKPAKPQNLFNPASTSSDNKNLLDHLSKAPERKGSDGILPSTEAIVGIPLAFGAICLNSTGLDLFQSSDALERFFDIFESPVHVKCMKNDSNLLRLLGNSFDELVRHHPALKASVMSSVLRMVARVGLLGKYKAWESGLGAKLWVEDQDGKESISGGVSATIGDLCSDFFQNEDYWPSASVPNLGNASTSYRELFGEPDTSKWTTKDTDADGLAVTGYIFPVLKFLGAFFENQAICANFIENGGVEYVLDFAVLQSLPFSFHNNEANHQLAQVIHLMAETKPHLVLPPLLNRTLSALDKLEPFWSSDLGSVGFFSPFTSPLQAFESSPEEVELKMKGTYYAKHLVAVGTLTNILREVYTPPIYPTRPAQQPLPFHQVNLADKYALLSERLGRLHAACVWEEILLQQDMPEAWNEVTKLPGFSIEALGEGRETPPAITADGGSEAGDVAAESHAEDTQTAQGGRAKKSPKVDNPASTQLDKGANVKNVKTLRWLLGTVPTCITGFLHSLGRGLVAKRRVDTYQRQKAAVVAGAIASMCLTMILVAFKRQNGIQKMKEIADIFLQEVKELAPLEHSTSSPRDRPARLASAYGGIKIILTFFSEMTSARYVLDSAQTLAMASNDRDRERFDTFLPQQFLVELRMEALPLVKSMWTSDFVETASSSIVKSLIEILRLVLEAEHENNAYRRGDNMPRLQVAALRAFAIHPERLGQLVEKGYDESLAREALYRCYNSSSAAEEYCNAQKGVRTPPRSAIPDYDAEAAVAKPGITSQGDHVSGSRTGNDTSPGPSAQSAQDLVDPIASILAEIHAEATEAMETEGDTSSEASPPSNARAESSAAAASTESKASEAASAGSPKKREFVTIDDLDKERDIIRSNLIERCLEVLNAHHDVTFELADLINSASKVENPFNFRREIGETLLHFLASLQMDENFLTGGKKIAAHASLLALLLQEPQFYESTLEPLQDNFYVLLGFVKVPPPTSEKSPDEPCPWIGQVLLILEKVLAEDASPKAIQWNPPNADTPEDFDVAELGEPLVSLEGKTQLFDALLEVLPRIGKDESLALSVARVLVMLTRERVLATRLGERRNLQRLFVMIKQLSNPSNEKLQNTFMLILRHIVEDEDTIRQIIRNDIITSFDSRPSRQTDTTNFVRQYSHLVIRAPRLFVEVTNELLKLSRYDANQRPQTLVLKNPKKIDGLQSSEETDKQEEAKTEGGQSPRAAKEADQHEPKESKEKHKELKTPIVEHPDGVVHYLLSELLSYRDVDDKESAPAPPPEKTGNRAEDIEMATGESSSSSQATNRETSSKKPEKPQFKAEDHPIYIYRCFLLHCLTELLSSYNRTKVEFINFSRKADPLATTPSKPRSGILNYLLHGLIPIGTMEHDESIPFKKRVNTSGWAMKVIIALCTKTIEYGGRRSLPSQEEEVESDLVFVRKFVLEHALKSYKDASASREPLDSKYARLMCMADLFDKMLSGGSGPDGTPRTSSATRQIAKTMFEKNFVNAFTASIADIDLNFPSSKRVVKYILRPLNKLSQTAVLLSESGSIEAKPNQSDSDEISSASSVSEFSSSREETPDLFRHSTLGMFEPHEEETSSDEDEEDEEMYDDEYDEEMEYEEDMPEHDGEVVSDEDEEEMNERGPIEGLPGDTPMDIEVLIDGDSEDEDDVDDDDEDDADDDEDEDEDDGDDHLDERIVAGEITGDNDNNSLQDGEDEWESDEGSEEADDELAMMNQLEIELGGGMGQGEHNRPGPPHIENLLRVLEETGATVERLDHEIDHGMDMRDLGEDFVEDDLNEEEANFSPDDDEEVDELEEEVDEFDDEQAIYHEYDHDDGDLSNSPWSWDEPVLTQNRVPSRNISSWNFFPGQMASRQGIIPVPDYRTHRTQVTQPGNDDGVNPLLRRYGRPHEQPAQRRGQNAEAFSDWVTAMDQNSHGRLLSIDSPVTFMNAIMQAIGQGGPEFGIIPRPDGFHLHVERGSVLPGRLQDLLGLGRAPAVTPRSRDDPGQAVAFPTGSTLNRWQEEARLHFNNLYMERAQRIVQSILKLLIPPAIEEDKQRQKKLEEERKRLDEEKLEREKQERIAREEVEKEKKRKEEEEEARKLEEERRAEENAQAGDAEPMEDVQPTPGAAEQPSTEAAAPEAGPSEPVQRVHTIIRGRQLDITGMEIDPEYLEALPEEMREEVILQQLAEQRSQAAVAGEEPSEINPEFLEALPAEIREELLQQEAADRRRREREAARRQAAANGGPHAEDMDPASFIATLEPSLRQTVLADQPDDILASLGPEFVTEARALTGRRLPRFGDPVLDPPPPARQTQEPKKPQRRQIVQVVDKAGVATLLRLMFMPLQPNARHHVNDILHNVCQNRQNRSEVISLILLILQDGSADISAVERSFAHLSLRAKTPTSQRTPQSLKRALSLPAPGANHDVTPLIVIQQCLGALSFLTQYNPHIPWFFLTEHEAVSALKMKALRKGKAKENRANKFALNSLLSLLDRKAILDSPNCMEQLSGLLSSITHPLTILLRRESDKQEDSEIKEAETKPETVTQPQDAGETQASNPPDTTMAEPTAGTTSDTAGQQEQAEDGNTEGDKSSKEDRKKKVRTIDPPVVPEYNLRLVVHILSARECNGRTFRETLSTINNLSSIPGAKEIIGKELVGQAQTLSKSILVDLEELKPHITNAESGTDVQGMALAKFSPASSDQAKLLRVLTALDYLFDPSRDKEKISEAEASEKANTLKALYESVTFGPLWTKLSDCLHAVQRKESMLNVATTLLPLIESLMVVCKNTTLKDIPLFPKQGREFSVSSPPPDSGMEGLFFNFTEDHRKILNELVRQNPRLMSGTFSLLVKNPKVLEFDNKRNYFNRKLHSRGTEVRHPHPPLQLSVRRDQVFLDSFKSLYFKTADEMKYGKLSIRFHGEEGVDAGGVSREWFQVLARGMFNPDYALFIPVASDRTTFHPNRLSGVNQEHLMFFKFIGRIIGKALYEGRVLDCHFSRAVYKRILGKSVSIKDMETLDLDYYKSLLWMLENDITDILTENFSVEVEDFGETRVIDLVENGRNIPVTQENKEEYVQHVVEHRLTGSVKEQLDHFLRGFHDIIPADLISIFNEQELELLISGLPEIDVNDWKNNTEYHNYSASSPQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFRELEGMNGFSKFNIHRDYGSKDRLPSSHTCFNQLDLPEYDSYESLRKCLYTAMTAGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD09</accession>
    <name>D4DD09_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_05015</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020877.1">
        <property type="nucleotide sequence ID" value="XM_003020831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD09"/>
    <dbReference type="GeneID" id="9577708"/>
    <dbReference type="KEGG" id="tve:TRV_05015"/>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="504" mass="54586" checksum="BE2769E57F0CBD51" modified="2010-05-18" version="1">MRGVLVFSGTSHPTLTEAICDRLGTLPAPCELRKFSNGETSVNIGASVRNQDVYIVQSGSRKINDSVMELLIMISACKGGSAKSITANYAAFQRYFPYSRQSKKKSHRGAITARMLANLLSVAGVDHVVTVDLHASQMQGFFGKPVDNLFAEPLIARWIRMNVSRWNEAVVVTKNAGGSKRVTSLADALKLNFGIVTTDRRRQRQAKAGTMTDSAIFFDSVEQGFTTSHDGEQKFDRIPSTTIRRSVVSATTESGILTPRNSTSDSSANPAQESESYRTPHPDSMLAPSTLADGFSSEYTDERAREVITGRLVQGHLVDDDYPSPETASTSASASNHGADAYEGSIPDPMSMSAVSNVSGYQPGHALGGSFDAAASSDEEDVCPQRSGQERMITLVGDVKDKTVFIVDDMIDRASSWIAAAETVVKKGGAKKVYCIATHGIFGDDSMEQMENCPSIDYVVVTNSFPLPIEKVRLMKKLVVLDLSALLSESIRRHHNGERFASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDF8</accession>
    <name>D4DDF8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_05169</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020718.1">
        <property type="nucleotide sequence ID" value="XM_003020672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDF8"/>
    <dbReference type="GeneID" id="9577417"/>
    <dbReference type="KEGG" id="tve:TRV_05169"/>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE40100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="557" mass="63821" checksum="265FF9A82807736A" modified="2010-05-18" version="1">MAASRKSTVLTRNEIGKQIADGRHIVIFEGRVLKLDAWLPFHPGGDKAIQHMVGRDATDEMNALHSAAAKERMKSFQIGRIEGAWVNFLPPIQGGDFSIYTSGDLSAAIESDDNSSGNGQSMPPSPLFEPADKKDSGLRRRGSVSTSISSVGTASPAKKDSETRPFFLDARTQEEIAFDTAKYPPVTAVEQERIVQKYRQLYKRLLDEGLFNCNYSAYLVETSRYLLLFGLFLYFLHCGWYGTSGFFLGCTWHQLVFTVHDAGHLGITHDFHTDTVIGILIADFIGGLSIGWWKRNHNVHHIVTNSPEHDPDIEHMPFFAVSHRLFDSLRSTYYERVMEYDFAAKFLIRFQHFLYYPLLCFGRFNLYRLSWEHLIRGQGPRKGAAWWHRWLEIAGHVFFWAWFGYGVLYRCIPDWQSRVLFVMVSHMITAPLHVQITLSHFAMSTSDMGVHESFPQKMLRTTMDVDCPQWLDFFHGGLQFQAVHHLFPRLPRHNLRRAQKLVIEFCEETKIPYAIFSFVDGNKEVIGHLGDIAKQARMLAECQKSIAEKGVFSDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDI6</accession>
    <name>D4DDI6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020671.1">
        <property type="nucleotide sequence ID" value="XM_003020625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDI6"/>
    <dbReference type="GeneID" id="9577370"/>
    <dbReference type="KEGG" id="tve:TRV_05197"/>
    <dbReference type="HOGENOM" id="CLU_1427655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="192" mass="21197" checksum="9A61F7837FAFC1D6" modified="2010-05-18" version="1">MAPLSLLRRSSSEPHHLAKRYYHYSYGPTVGGIIGGIIFFILIIVLLFRLRRRRPATTTYVAPQASAAATATSGAQGNQTNVYVMGQGGPLPPQQIPLQNTSPQPYPQQPFPQQQPYNQQQQPYPYPAQSPPPQEQQQQQYGYMPNQGPAPPQQTYAPQGQPGYQQPYYQGDGISSYPVGAPPPSYKDPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY5</accession>
    <name>D4DDY5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020562.1">
        <property type="nucleotide sequence ID" value="XM_003020516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY5"/>
    <dbReference type="GeneID" id="9577260"/>
    <dbReference type="KEGG" id="tve:TRV_05349"/>
    <dbReference type="HOGENOM" id="CLU_013935_0_0_1"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="591" mass="66362" checksum="4599F5D050490CA7" modified="2010-05-18" version="1">MVTIRRDGEEVRAGDDGEMGDAVRPAKSAQRAMFERGFRAWSGLVDTARKATGLPDSCFDLNMLADVPSLSPGLDLKAEDGWLRATGTSTWATDGSDNSVYIEKQIDIDISRRWPTNITLTDRDLDYCSWFGRADNHIAVLVLAWAYILSARWTELVSGAVLEYNNNSQIVDGDHVISVNTGKVNDDAARWWAAVLSQDGWEAYIPSDESRFKSPWSIALKSPVRFRLSHQGETLVQPKAISSVDALGYIKEYCNFHGVTDQCYAALSVALLLPRLSSRGRNVPLPIPKLNHEACVSGIIKERASHEQLYEFKYLDKFLVLSCNTKGVCGLLSSIFYDPKVACNFASPWVQAIVAAIKHVGDTQIIHVMAARSPHLAFIWLGAIITGFHNDVVRDGRFGLIPIEPHSAMWTGTIQSFMQEPLSKPLVTDGYISRANECRLLHIIQDEFHERWPLSPWHPFGQTALEDTEPSVRSNVEKVTGGLVYAKWRWASKEGSLTHQVPRGSLVPVFRELAEVPDIPVSYEGFRDKDVVSENATRMIFDWLRFEGYPASERPIYTHEWFAVDNSDEDAHFQAIQKAERLRRRGLGQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE49</accession>
    <name>D4DE49_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_05413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000283">
        <property type="protein sequence ID" value="EFE39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020519.1">
        <property type="nucleotide sequence ID" value="XM_003020473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE49"/>
    <dbReference type="GeneID" id="9584245"/>
    <dbReference type="KEGG" id="tve:TRV_05413"/>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="37749" checksum="5E74A91633C14617" modified="2010-05-18" version="1">MADFSSALSFLTDNPAAGVLKDSYDAFARRRADLGLSNPGTVEMVSREVQKDVLLSNFMFTGLRADLTKVFGVSPLFRISHAFTMGSQGNLPPYALSTMFGTSDVLMQGNIGSDGALAAVANYRWSPSLISKANVQIMPGSAQGLIQLDNDYTGSDFSASLKAFNPSILEGGLTGIFIGSYLQSITPGLALGLEAMWQRAGLGAKPETALSYCARYKADDWIASAQLQAQGTINASFWKKLSDKVEAGVDMNLQFAPSGNPMMGGSLQREGTTAVGAKYEFRASTFRAQVDSDGKVSCLLEKRVAMPISLTFAGEIDQVKQTAKLGLAVSFEMASEELMEQQESGELASVSPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEI3</accession>
    <name>D4DEI3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000295">
        <property type="protein sequence ID" value="EFE39739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020357.1">
        <property type="nucleotide sequence ID" value="XM_003020311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEI3"/>
    <dbReference type="GeneID" id="9584096"/>
    <dbReference type="KEGG" id="tve:TRV_05550"/>
    <dbReference type="HOGENOM" id="CLU_567375_0_0_1"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="482" mass="52785" checksum="DF142D46D706D22E" modified="2010-05-18" version="1">MPQYFKNDLCLVPIDKVSLQNTLTELREAIVRAFALLKANSPAPDINDTKAFGSLYTGDNAKYLGGNKAETDALISSAYSLAKERLSPHLVEIHPHHGQVSPTGSVHLGAAFARTFAAAANMTSRNGGVCRIHSRDVACVCEAFDHACDESYGLGYDDALSGRAGLLRAVLAFRHFRLDRETAASYELVFKSVPLLVDCIIEAGKIGAEMFVEEHGESGILAILLECKLEELGDGAPESNHLPIIGKTITQLCKLTIANEGHLPSSLPHNPLARRSPLVQICHGAPGFLVLLARARGIARLASLEWEPCWDHAIYLASQRVWEQGLIFKGGGLCHGIAGNAWPFLMLHNLFEYGPQGSRADRIAFSEKLARTPPPPQKYSADQYLSRALAFLLHVRKTQPFNTHTYEESIQYRMPDHPYSLYEGLSGTMVAWAEACVVIVARLRKMEVDEIVGHGAYHTDGAFCRDLRHVLGIPGIAVQGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEY4</accession>
    <name>D4DEY4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000315">
        <property type="protein sequence ID" value="EFE39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020206.1">
        <property type="nucleotide sequence ID" value="XM_003020160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEY4"/>
    <dbReference type="GeneID" id="9583978"/>
    <dbReference type="KEGG" id="tve:TRV_05725"/>
    <dbReference type="HOGENOM" id="CLU_008392_3_1_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="536"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="703"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="855" mass="94782" checksum="AD7659A9F13A1AB7" modified="2010-05-18" version="1">MSEEEEIRRSLGQLFIVGFDSLTASEDIKSLIKAPFYIGNIILFRRNVHDSEQLITLTNELQQTARDAGHARPLFIAADQENGWVSQIKPPIATQFPGAMALGATGSIEDATQIGRATGEMLDALGINMNYAPVCDVNSEPSNPVIGIRSPGDDGASVGRIASAFAKGLREKKIVPCAKHFPGHGDTTIDSHYGLPIVGKSIEELEACELIPFRRVTAENVESVMTSHIVLPALEESNLPMTLSKSCVDFLRERLQYDGLLVSDCLEMDAIREYYGTEKGAAMAIAAGVDCAMVCHTLKVQVGAYNEVYQAFKQGDITSEGVAKSVARVAALKDKFISWKSVFRKRKPELLSELRLAHERLSTRIYARSTTLVRDTQKVIPLKPAENVVYAYISLVGENVAVPHTLPHTQSKFWDVIKQYHSYTIECPVLQDIILEDDEMTKAKISEADAVILVTKDAKMSVDQVELTKLIEGLSKKLIVVAIGGPYDFLEDEDFVKTYLTIYEPTVEAFIPAVRIIFGDIDAKGKLPVSVKPCQVPIEPFNADRDLAKVVELWHGLLPRYAVPSATLSHVLSRPNGNHLVSRVEDKVVGFVATYTNEDRPTAFIPVVLVDSGHQGKGVGTALIEHARIYLRNGYSTSSVTIGSSFPRFWPGVPMDISKQAQEFFIHRGFCPERRPTARDYTVDLLSYEAPKGVLERAEKAGVTYAPWRKEQYEECMEKQRKLFGKDPVWMEAYEGLAQTGQYNQVMVATDSSTGEQIGWTLMQELGIGMTRELAMQQLVGIKSGQIGCVGVVPEARNKGVGLALITHAALDLKRRGMEHVFVDWSNHVNWYERAGFKVWGEYRTMVLHELAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV4</accession>
    <name>D4DFV4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019859.1">
        <property type="nucleotide sequence ID" value="XM_003019813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV4"/>
    <dbReference type="GeneID" id="9584610"/>
    <dbReference type="KEGG" id="tve:TRV_06057"/>
    <dbReference type="HOGENOM" id="CLU_1180943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="26017" checksum="E43A528BB9B57259" modified="2010-05-18" version="1">MKSLISRSSITGQQLAIAAVALCLERPTKAPDAINSTDMVLGIPYINRKSRDELDVVGLFLEPLPIRIRYTADGSTDKAESYLKAVQQSVQESVGHSIHWDQLLEHLQVRTSAPDHPLFETVVTFHGRDHSNGLEISAPGFETCYTFTDGAKFRLLCEFSAVSEDKLVLRMEYDTDCFSLDDIHLLQTRIPLAIALLVQGVPYPVIRQRIASLCDAPVVKVLQPDVVFGLPLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFV8</accession>
    <name>D4DFV8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase GliM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019863.1">
        <property type="nucleotide sequence ID" value="XM_003019817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFV8"/>
    <dbReference type="GeneID" id="9584614"/>
    <dbReference type="KEGG" id="tve:TRV_06061"/>
    <dbReference type="HOGENOM" id="CLU_005533_12_2_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="252"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="432" mass="48567" checksum="D35E17FF8EE039DC" modified="2010-05-18" version="1">MVAITNPAITAVERSSLESTLKTLISQVEATRNALLENGQRGLLQTLHTDKDLPDSAVEVLAGKAINILHETKQLLEPGHLVLADHFLGYVSTKCLCAAVELKLVDILANAGEEGLTIAELADASEANPDRLQQIMHVLHNNHIFEYDPASHRYRNNRISALLHTTHWTQWHNWVDLYGNEFYDIARGIPQSIRRDEKKWGAQINFNTSDDMFTYFQAQGWLPRLHRTLGGGAIAQAPGILADYPWHEFGSRTVLDVGGGGGGFLVSLLREYPDLKGAILDLPRTIEHATTLFHNSDGAYYDLRERVPRENLIGGDFLKSVPSFEVYTMKWVLHDWKDPDVITILRCIRAALIPGPDSRLVVLESILSDGQYGRLSRYGDINMVMTANGQERTEEQWQELAAASGWEISKIYPLRRSWVCAIDLRPRADWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG22</accession>
    <name>D4DG22_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_06124</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019836.1">
        <property type="nucleotide sequence ID" value="XM_003019790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG22"/>
    <dbReference type="GeneID" id="9584587"/>
    <dbReference type="KEGG" id="tve:TRV_06124"/>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE39212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="28809" checksum="EF32C2B699072C77" modified="2010-05-18" version="1">MSRRSPAAGGNGPESSETPKDAGQDKQKILLSADTGHFSLIRCANSWNITDDDCFLPLLTRRFDNSRALHLADFITELNVMSIFSSLRYCLGESHQHGNIWMALGFIPFGLFFDFMDGKVARWRKKSSLMGQELDSLADLVSFGVSPAVAAFSIGIRSPVDHILLTLFVLCGLTRLARFNVTVATLPKDKTGKSKYFEGTPIPTTLVLVGIMAYWLSQGWILEDLPLGVMLPGTALEFHPVVGMFLVSGCLMVSRSIHIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ1</accession>
    <name>D4DGJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_06295</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019666.1">
        <property type="nucleotide sequence ID" value="XM_003019620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ1"/>
    <dbReference type="GeneID" id="9583583"/>
    <dbReference type="KEGG" id="tve:TRV_06295"/>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="288"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="796" mass="89393" checksum="6275C2F1E4C5EF3E" modified="2010-05-18" version="1">MLRVLQPRPWTCHRCLLRINVGTSRCYSVAVPERTRLDPAIAGLSGTKRHDDTNLRLVFDSNSFWREFSQRQSASSRRTGLLQNQYLTNPEGFRKFAHISLHKCQKIVGKVLAASTMEDFRRMAKDLDQLSDLLCRVIDMAEFMKTNHPDPAIQEAATEAFAFIFEYMNILNTTPGLHEQLKRAIENPEVTSHWSEEENVAATAFLRDFAKSAIHLPPEDRHRFVTLSNEISQLGPDFVKNMNPETSQLSFSKNQLQGMDPDLLRKLKRWSKVTIPMYGSTPKAALSTVEDAEVRRQIHLAYRTSSREQIGRLETLLQRRAELAKLSGYQSYAHMTLSDKMARTPEAVVNFLSSLNASNRGQLDDELSQLLALKQIESPLATNLQPWDYSYYMEKYYVKHGRARRSRDTDLLPSFFSLGTVMQGLSRLFTRLYGVRFVPSETLPGETWNPDVRRLDVLDEDDNHIAVVYCDLFSRPGKSPNPAHFTLRSSREISPAEIAECASLPDSPHPNDGMATGLKPGTNRLYQLPTIALICDFDTPASSTPSAKPSLLSEHSVRTLFHEMGHAIHSVLGRTDLQSISGTRCVTDFAELPSVLMESFAMDPQVLRLYARHWSTDDPLPEDMVQNIHRNRQNRDSIHGGMDNETQIIMALMDQAYHTTSAGCHIDSTAILHAVSSKHSSIPDPADSKTAWQGYFTHLFGYGATYYSYLFDRAIANKIWTDVFGGGDLSVDRNAGERFKNEVLRWGGGRDGWSCVAGVLGASNPANSNGRLSEGGEEAMREVGRWGLGKTGSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGM2</accession>
    <name>D4DGM2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019655.1">
        <property type="nucleotide sequence ID" value="XM_003019609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGM2"/>
    <dbReference type="GeneID" id="9583555"/>
    <dbReference type="KEGG" id="tve:TRV_06327"/>
    <dbReference type="HOGENOM" id="CLU_3408158_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="30" mass="3204" checksum="4D13756D9B7B95A9" modified="2010-05-18" version="1" fragment="single">KKGYPAAAAAAAAESQQAHGMKTYQHYKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP9</accession>
    <name>D4DGP9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019636.1">
        <property type="nucleotide sequence ID" value="XM_003019590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP9"/>
    <dbReference type="GeneID" id="9580166"/>
    <dbReference type="KEGG" id="tve:TRV_06354"/>
    <dbReference type="HOGENOM" id="CLU_067899_0_0_1"/>
    <dbReference type="OrthoDB" id="4826573at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="298" mass="32402" checksum="139A98A71C9BD312" modified="2010-05-18" version="1">MAAMSSSDLPANILLSRSQPLSPWLQEIIRTKLSELNLSDTSVREEKGATVPDLGLRSQPLSTPGDGGSPWALLQQPSGPTPAPSVQADKKPAHAPSCRLVEIGEFLVDMMALTSKIASALVEAEDIKTYIEAHIQQLNEMHHLSDMDMVTYMSEKERDLNTLATRLEEMANETSMVWRRSPNPPHHMGDVLQTASSAMVSCRSNNNSSTGSQINPNCAMGPDFNSGSPTPTVSWSSSTNNAAEETAFPVSMEAFQNTYPNLNRRGVGNWVCPYGEKCTKGGFRDGKVVIFGRNSSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGU2</accession>
    <name>D4DGU2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019601.1">
        <property type="nucleotide sequence ID" value="XM_003019555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGU2"/>
    <dbReference type="GeneID" id="9578375"/>
    <dbReference type="KEGG" id="tve:TRV_06397"/>
    <dbReference type="HOGENOM" id="CLU_2903760_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="62" mass="6447" checksum="4BF6A5237EC830B9" modified="2010-05-18" version="1">MSADMEAAVKLFFSSPRFAVAGASTDASKFGYKSTKDTLSSAGDDDDDDADIVAFSSSRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGZ1</accession>
    <name>D4DGZ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019572.1">
        <property type="nucleotide sequence ID" value="XM_003019526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGZ1"/>
    <dbReference type="GeneID" id="9578346"/>
    <dbReference type="KEGG" id="tve:TRV_06446"/>
    <dbReference type="HOGENOM" id="CLU_2980780_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="58" mass="6724" checksum="42FE583D2933BE20" modified="2010-05-18" version="1">MTGQGEEDAAGWSRGREEEEKGREERKNKGKGTGNKQQQRRRKRRRMGDQASLQQQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHM4</accession>
    <name>D4DHM4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional co-activator (Hfi1/Ada1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019276.1">
        <property type="nucleotide sequence ID" value="XM_003019230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHM4"/>
    <dbReference type="GeneID" id="9577517"/>
    <dbReference type="KEGG" id="tve:TRV_06680"/>
    <dbReference type="HOGENOM" id="CLU_038277_1_0_1"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47791" checksum="4F54A351995241DF" modified="2010-05-18" version="1">MQIDPAALTGTTDFATVAPASTTTKPVPTGPPIAQKTTKALISVPRLDVEPIYTELKSAIGDGWTEYKQAITLFLLGFGVLTIFFFLLGHLNQNEFTLRAAPLLAVDPKRERLHNNFVCALLGNLTRDLPDHGVASWVSANDKPTVVSKPASGDAAEQRLKTEVMQLPPRDRRRLKAIPEPDPSTLPNPLEEYQLARQIRLPDQVPASAGGLNKTNWELEIRKRYAQPLASETGEFPDSESIYARMTPICYEESISNGATFACATYMAIATENFVKSFLSNVFGRTKCNGPSGTINGMTTRKYRRQLEREEMAFTRGELVRNTTNGLLPVEAKEASNRQPLGLRDLKLTLDIAPGALGHMPLIISQIMGGYLEEELEAENQCYIQEANAATDSADHIPSGDEMDIDEEPWDWDGATAADHSQLNSILDECLSMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV0</accession>
    <name>D4DHV0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Farnesyl-pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019208.1">
        <property type="nucleotide sequence ID" value="XM_003019162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV0"/>
    <dbReference type="GeneID" id="9577205"/>
    <dbReference type="KEGG" id="tve:TRV_06757"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39738" checksum="A2A318929AC71AA3" modified="2010-05-18" version="1">MTSSTSREDFNKVFPALVQDISEHAKEYNIPAPALEWLQKNLNENTPGGKLNRGLSVPDTALALLEKPLTEEQFKHLGLLGWMTELLQAFFLVSDDIMDSSITRRGEPCWYRRPGVGMIAINDAFMLESSIYVLLKKHFRSHPAYIDLVELFHEITFQTELGQLCDLITAPEDNVDLNNFNMDKFNFIVIYKTAYYSFYLPVALALHYLQLATPNNLRQAHDILIPLGQYFQAQDDYLDVFGKPEQIGKIGTDIQDNKCSWVVNQALKRCTPAQRKVLDECYGRKDAAMEAKVKAVFNEMNLQKVYHDFEEEQVSKLKNMIASIDTSEGLKGSVFEIFLAKIYKRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHW3</accession>
    <name>D4DHW3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019221.1">
        <property type="nucleotide sequence ID" value="XM_003019175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHW3"/>
    <dbReference type="GeneID" id="9577218"/>
    <dbReference type="KEGG" id="tve:TRV_06770"/>
    <dbReference type="HOGENOM" id="CLU_013967_2_0_1"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="446" mass="50543" checksum="22F2A32B55CEE3E7" modified="2010-05-18" version="1">MVYEYLLSNNISGEFTTAPGPTSLRSMHLNFWTTSCIKANFPYNPFSHPFRIYGIEMLSQVYSKLDDLAIPSFMLFLGDFIYIDVPLQFGSAIKHYRDEYQKVYASPSWHTGKNPAINLPWIHMLDDHEIQNDWHDGNVTEPYPAAIEPYHHYHVSVNPPKAKSPHASQENTTYFSFTRGPASFFILDSRTYRSPPGLDNSTMLGYAQLQSLLDYISCPEPAPVKWKIISSSVPFTKNWHIGTSDTWGGYLKERQILLEAMWRAERTLGTRIVLLSGDRHEFAATKFPNPATKQTDSSSSSLSKGEGQGIYEFCAGPLNQFYLPSSSYYQTDDEDVTIKYIPNGNFKFGAVGIDIHPDGGSDLTYTLYVNSEAVWQYKLSMPSDIKAGEAEFPDGEEVFDLVSRPKGKLDMGVLMFWRGLYWLNSQVSNLVEGVNGLILKKERLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHY9</accession>
    <name>D4DHY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Palmitoyltransferase with autoacylation activity Pfa4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019190.1">
        <property type="nucleotide sequence ID" value="XM_003019144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHY9"/>
    <dbReference type="GeneID" id="9577193"/>
    <dbReference type="KEGG" id="tve:TRV_06796"/>
    <dbReference type="HOGENOM" id="CLU_027721_8_2_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="207" mass="24177" checksum="7C6EB0C5212A841D" modified="2010-05-18" version="1">MLGANETTIEGWEIERHRTLCRRARALGGYLEGPDGVKVWIKRQEFPYDIGVWNNIRDGMGGSNNSTKLMSEDESLTWPPPDPDRMSRNTPQRQDRTTLLGDGRNFDYDEVEAFHKRQEADYLRQRAVSEVRRRKPFHKRYIKKGDDGHLSNISDSEDEELSNSGEEGWRNSEGERLKDFGVDEEVEFYDEDDIPLAELIRRKKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI14</accession>
    <name>D4DI14_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000392">
        <property type="protein sequence ID" value="EFE38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019137.1">
        <property type="nucleotide sequence ID" value="XM_003019091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI14"/>
    <dbReference type="GeneID" id="9580084"/>
    <dbReference type="KEGG" id="tve:TRV_06821"/>
    <dbReference type="HOGENOM" id="CLU_056566_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="271" mass="30248" checksum="451C05238FF49E20" modified="2010-05-18" version="1">MKSQYGVERARVEVRRDGPLGNKQGKKKKKKKKDEAEDEEEKASSQASERDGDDDDDDDGGGSEVNEESTRTGSSNKDGWPAMTYSPSRLQIIKSQRATQRRAKSDLSKSQRVWALIQLTFHGSTGEGAGEKDEARGWDGIRGKGSGGQGQERDLRHGDEETRRRRRRRKRRRCWTMEVVGDASPAYDRLSPLRRQASYPGDVGQDEDEGQETETGQQGGRQRGTMMQRVHQEQGREMSPAAASSSSVLPRSAHELSTSRQAMGKPETRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI38</accession>
    <name>D4DI38_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000394">
        <property type="protein sequence ID" value="EFE38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019122.1">
        <property type="nucleotide sequence ID" value="XM_003019076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI38"/>
    <dbReference type="GeneID" id="9580078"/>
    <dbReference type="KEGG" id="tve:TRV_06845"/>
    <dbReference type="HOGENOM" id="CLU_052079_0_0_1"/>
    <dbReference type="OrthoDB" id="5427699at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="432" mass="47024" checksum="9F4221ECF289CF3D" modified="2010-05-18" version="1" fragment="single">PVKRHTHKHNKEESRERDGEENSLSKYDIRHHPTSLYKSPPRGGGQGHLPMNLAPADQSPIRYHHNHPLPPLPLPDDNSGLQAYIEQSRAALQSQRASFECERFAFGEERKLWSQERELLKSRIASLEKHINCTHVDMSTVEPVSQAGNSSSASLRVWEGSRPTGKPTRRFLDGTTAAGPLAPAAYDPPFLQVDDHLASGRSPSLDEALSPRTQPVDRAHHVAIPVELVDSSLDGITLKSTGLPPNVAAKLTSPPLSTPNVSSPPQPGAAFTAAAESESRARYRTHDGCDAVTLQTAPPDAGPAATSSEPTVQAPMQRPRLTTHTTDEQPKFTPDADSPEHTYAEVEADEDPELTGPLMLRNDEEHNLDFLEALDKKLLMEAKKAVSTNPALSDSDALSDAANPQSEPEPEIRFKKSTNFGTAFGSTQQHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI76</accession>
    <name>D4DI76_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000398">
        <property type="protein sequence ID" value="EFE38460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019105.1">
        <property type="nucleotide sequence ID" value="XM_003019059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI76"/>
    <dbReference type="GeneID" id="9582591"/>
    <dbReference type="KEGG" id="tve:TRV_06884"/>
    <dbReference type="HOGENOM" id="CLU_1866587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="137" mass="15000" checksum="F069EEA9F3CD7CF0" modified="2010-05-18" version="1">MRIPSMDDDGWSAVLRMECKKTPFVQPGFLMAEERLHFCSSASQNLSAGRFLFSSPPPVISAAFEKGERGQITSWRLASAKKQSELLRTSVLIKHHQTGTLAGGGNRYLACTGPSVRTFTVACNYQNVCVRAEMADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIF9</accession>
    <name>D4DIF9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018956.1">
        <property type="nucleotide sequence ID" value="XM_003018910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIF9"/>
    <dbReference type="GeneID" id="9582116"/>
    <dbReference type="KEGG" id="tve:TRV_06967"/>
    <dbReference type="HOGENOM" id="CLU_012862_9_3_1"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="207"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="473" mass="51783" checksum="43250E4C847D9EC9" modified="2010-05-18" version="1">MASNGSKITPLPPEEPVIPKNDNLAVPQDHHDRQIDGPSTYTEPRYITRQVKRQAMTESPSASSAKRSKVKRKQGNPVPAIDELPHNLGKIEILDAVVEGSAQDFALPTVPQLHSTDSSSSPAPYEAATSTPRRSRGPKSPYGLTPGVSPFPGWKRPTVAECEEINRLLSSVHGEVIALKAIPPPSLTVSGCGEVPSILDALIRTLLSGATTGNNSAMAFQGLVRKFGILKKGIGKGSVDWNKVREAPVEDIYEAMKCGGLGVAKSKYIKQILEMVYEENKARRDALVESKTGREIDLTRAPGSINETEEQKDNEIAMANENVLSLNHLHSLSKDEAMLEFVKYPGIGVKTAACVVLFCLQRPCFAVDTHIFRLSKWLGWIPSDKVNEITAFSHLEVKIPDHLKYSLHQLFIRHGKACPRCRAITTENSEGWEAGCIIDHLVQRTGKRKGGPLKQTKLGFPANKSMYKSVYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIK1</accession>
    <name>D4DIK1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dolichyldiphosphatase 1</fullName>
            <ecNumber evidence="4">3.6.1.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dolichyl pyrophosphate phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_07011</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018998.1">
        <property type="nucleotide sequence ID" value="XM_003018952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIK1"/>
    <dbReference type="GeneID" id="9582322"/>
    <dbReference type="KEGG" id="tve:TRV_07011"/>
    <dbReference type="HOGENOM" id="CLU_074922_0_2_1"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="15">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE38353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="155" mass="17297" checksum="CCE64AA48E115838" modified="2010-05-18" version="1">MNGKGYGMPSSHSQFMGYFAVFFTLFLLVRHTPSASIRSGYLSMLERVGLSSLACAGALAVALSRIYLNYHTPQQVVAGAAIGVAYGLAWFGIGSFLRESGWLGWALDLQPVRYFRIRDLLPREDLAEGGWQRWESIRQESKNPAKRHSKTSHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ21</accession>
    <name>D4DJ21_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000421">
        <property type="protein sequence ID" value="EFE38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018784.1">
        <property type="nucleotide sequence ID" value="XM_003018738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ21"/>
    <dbReference type="GeneID" id="9581181"/>
    <dbReference type="KEGG" id="tve:TRV_07186"/>
    <dbReference type="HOGENOM" id="CLU_1579643_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="169" mass="19021" checksum="67A8E43EDF1C1E9A" modified="2010-05-18" version="1">MLNESQVLPQALPHRNNPPHKRRRIGERGEIKAVEGTSQSEEEKEKTAAMPPQTVYDLDASEEESEPEWEDVSLPGPSTTSILPSILPAGHDIDQEPLQITLGKEAADQGKKGGVIRRKPVTGAEKKLRLEIHKVHVLCLLGHIRLRNTWCNDEETQVRTIPYMWCYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF9</accession>
    <name>D4DJF9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018637.1">
        <property type="nucleotide sequence ID" value="XM_003018591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF9"/>
    <dbReference type="GeneID" id="9580788"/>
    <dbReference type="KEGG" id="tve:TRV_07325"/>
    <dbReference type="HOGENOM" id="CLU_742250_0_0_1"/>
    <dbReference type="OrthoDB" id="4174058at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="39556" checksum="98B98889F1DDD327" modified="2010-05-18" version="1">MTVNSVDGGTRESSTFDTNDGVKTHQEEMDSQQDNSWSAIQDREYQAASSNTASSPNAAKKKKGRTGYWKEKKAAKKLAQAAVDGDLNDNGGVPTSVSADKDTIQLDIENVDPNATVEQDAPMPGSDASTKPKAKSKDRKKTKSAPSTAPLQDIWPSPPARDDGFVDDGWGNGTQTGWYHRDESLPREETKPKKIKPKKKAVKAKVADESAVQIGNSEPLNSKAGNVGASVNGEDPVEDGAASAGKPTVPKKTAKKKKAKADKHTAQEQEAPSMLDGVQVDETTGNETQPPTSTAAGSNDSTNGPAPVEANGVLHTLKQVFNGVNSNTDTPTPDASNTKDSKSKKVKIQVDLDVELASVLKAKVKGEMMITFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJT6</accession>
    <name>D4DJT6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018508.1">
        <property type="nucleotide sequence ID" value="XM_003018462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJT6"/>
    <dbReference type="GeneID" id="9584437"/>
    <dbReference type="KEGG" id="tve:TRV_07454"/>
    <dbReference type="HOGENOM" id="CLU_003537_1_1_1"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="888"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="872"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="878"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="984"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118763" checksum="1F47E2248F3839D7" modified="2010-05-18" version="1">MSHPGNEQQFASEDEEDFNPAPAGDSEPEAEDDQQDNRSGGKHIDNDDGQEVGKNKKEDDEENGDEVKKMNDGENGDLNTNESQQARGEDEAGVEDDDEGEPEGDNEDDDEEEEEEEEDEEAVTGRPRKRRRHGLGAFFEEEAEVDDEDEAEDEEDEIEAGFVHHDDEVVLPAGAETDDRRHRELDRKRDMDATMDAEQQAQALKERYGRNRASGADLVVVPKRLLLPSVDDPSIWGVKCRPGKEREIVFSIIKRMEERPLGSRNPIKIISAFERGGTMAGYIYVEARKQADIIDALDGMSNIYVRSKMTLISVKEMPDLLRVKKSEELTPGGWVRIKRGRYQGDLAQLEEVETNGLNVTVRLVPRLEYGLNEDSNAPALDPKRKRIGGGSSAIARPPQRLFSEAEAKKRHSKYLSATSSLGGKSWSYLGDTYVDGFLIKNMKVQHLITKNVNPQLDEVTKFARGADDGTSNLDLASLAATIKNTTEEDAYLVGDTVEVFAGEQRGVVGQTVATRGDIVTIKVTQGELQGQHIDVPTKGLRKRFSEGDHVKVIGGSKYRDELGMVVRIKDDRVTILTDMTMQEITVFSKDLREADDIGVDGKLGQYDVHDLVQIDQTTVGCVVKLDRESMRVIDQNGSTQIVLPSRVLGKIEHRRHAVTTDRNGSEIKCGDTVKEVTGEQRTGTILHIHRAFLFCTSKVVGDNAGIMVTRAINVTTVATSGSKLGRSAPDLSKMNPALQKNGMNGSGMPPPRTFGRDRLVGKTVHIRRGPFKGLLGIVKDTTDIIARVELHSVSKVVPVEKENLSVKEYVLLIILYFILSSANPHIRSPITGQPVDINRFGGRGGGAPRVPQSMATGRAGPQDAAWQGGRTPIAMGDSSRTPAWRASSSRTPAWNAAVGSRTPAWKAEGSRTANPYDGNRTSYGGFGGRTPAWTSGTKTPHDAGSGFSGGSSNSGFDAFMAGSRTPGHPGAMAANSGSRTPAWGHSGSSSSHLSANAGRAFDAPTPGGDYAAPSPAPFGSAPTPGATAATPRAWPDNAPTPGASTFAGKRMDGDAYDAPTPAGDHRPYDAPTPAIGMGFPATPGAMDDAPRYAEGTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK89</accession>
    <name>D4DK89_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol binding protein (Osh5)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018374.1">
        <property type="nucleotide sequence ID" value="XM_003018328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK89"/>
    <dbReference type="GeneID" id="9584307"/>
    <dbReference type="KEGG" id="tve:TRV_07610"/>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47649" checksum="82EC8F44E1B40215" modified="2010-05-18" version="1">MSASKDVGSGVPASSKGSWATFLKSIASFNGDLSSLTAPPFIISSTSLVEFSAYWAEHPALLVAPSREQDPQKRALLVLKWFLSTLHQQYCSRSEKLGSEKKPLNPFLGELYLGKWADDGDVGDTLLFSEQVNHHPPVTAYAIENQKHGVQLQGYNAQKASFSNTINVKQIGHALLSFPTPGSTEKETYLISLPSLHIESLIYGTPFVELNKCTYITSSTGYMAKIDYSGRGWLSGKKNSFSAILYKQSEGEKRPLYTVDGQWSDSFSIKDASTKKEIDSFDVKKSKTTPLTIAPIEEQDIYESRRAWRDVAAAVETGDMDALSAAKSKIENAQRELRKVEAEEKREWERRFFKRIDLDGSDGDNEDNTVFKNLLKTVGFGTDGSSSACSFIDSDKTGGVWRFDSARSKDAKSPYHADSAKGVGLAVSPPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKB8</accession>
    <name>D4DKB8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000463">
        <property type="protein sequence ID" value="EFE37705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018350.1">
        <property type="nucleotide sequence ID" value="XM_003018304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKB8"/>
    <dbReference type="GeneID" id="9584278"/>
    <dbReference type="KEGG" id="tve:TRV_07640"/>
    <dbReference type="HOGENOM" id="CLU_2607753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="7239" checksum="8BED776FF19A1ED0" modified="2010-05-18" version="1">MEAVAVAGSGFGRGYANGAVDAGADAGAADVAAAAAAAVAAVADAADAGVVDGEEGELGLGLELELLGLAYTAGSEDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKP5</accession>
    <name>D4DKP5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000478">
        <property type="protein sequence ID" value="EFE37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018222.1">
        <property type="nucleotide sequence ID" value="XM_003018176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKP5"/>
    <dbReference type="GeneID" id="9579592"/>
    <dbReference type="KEGG" id="tve:TRV_07768"/>
    <dbReference type="HOGENOM" id="CLU_1455404_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="186" mass="19707" checksum="E014E08F1B9FE8AE" modified="2010-05-18" version="1">MPDIQFPGAVIPLQRGERRGQDHGLEPADEMLPADAAGRHEFAPTTRRRQLAVLICSFLAVAMTIGPNFSYGVFQEYYVTSTDSVLDPSEAKNRAAVALVGTLGAGLTWSGSIVINPLVSRVSGNANQKIATAGCCLMSASYALASLSQRVSESKQPHPTPYLLALYSTSNVLSLSLSPCIPAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKX8</accession>
    <name>D4DKX8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DEAD/DEAH box RNA helicase (Ski2)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018156.1">
        <property type="nucleotide sequence ID" value="XM_003018110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579446"/>
    <dbReference type="KEGG" id="tve:TRV_07852"/>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="333"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="615"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1295" mass="145543" checksum="C89DFBC09EB6C94B" modified="2010-05-18" version="1">MSDGLEAAMQQLKIKMDAIDPDGDLDAWAKDEAVEKPRSRRIQPAEELKAELEREFLIPSPCFNTHWLNKLQRRWDYPTDYSKLFELAPTQSRTIIRFNREGLEGKVTGYHEVTVPAGSATAKNSTSLRRKPAIRADFVRGAAGFYPFAPGGLEAVDDISAIDAEAELDEDQTVESAPKKSSGLDRIINFGSQGGLLEIPPGFTRGLKFKIEENKDAQEGAEEVREALEDEDETELKHLPSQESGDTARKPGVEEGGEDSTSEDEEDIDALLPVEYPALEPRGQLIQSSLKKSRKEWAHVVDVNKEITNFYELVPDMAREYPFELDTFQKEAVYHLENGDSVFVAAHTSAGKTVVAEYAIALANKHMTKAIYTSPIKALSNQKFRDFRGTFDDVGILTGDIQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPEHVSLILLSATVPNTYEFASWVGRTKRKDIYVISTPKRPVPLEHYLWAGKEIYKIVDSEKRFIEKGWKDADDILSGRDKAKAQKAAEAQAARGGHQSDRGRGQGQRGSGQRGTGQRGGPQQRGRGQPSARGIGNIARTGRGGGRTSAAQDRNVWVHLVQYLRKREMLPACIFVFSKKRCGENADSLSNQDFCTAADKSAIHMVVEKSLTRLRIEDRDLPQIRKVRELLSRGVGVHHGGLLPIVKEIVEILFAKGLVKILFATETFAMGLNLPTRTVVFSGYRKHDGRGFRDLLAGEYTQMAGRAGRRGLDTVGSVIIVTSGRDEAPPITTLRKMILGDPTKLRSQFRLTYNMMLNLLRVEALKIEEMIKRSFSENATQALLPEHEKQVQLSEASLEKIKREPCAVCDVDLAACHQASVEYERLTVQLHTLLLASPVGKRMYAAKQLVVFKKNGVRTAGVLMKEGVTGGPIPSLNVFEIGPVESRRFPSDILPYMPVFREYFHPLPTSPENMVLKSCKVPIANLECVTGTTVRHPMYEIYKAELTLTQEALKVADKEFSKLCASWTDKSWDELDWERVKDMSVREVLEQRAQQVKIAKSCACLQCPQFLKHFEMQHDEWQVKENISQLKLLMSDQNLQLLPDYEQRIQVLKDLGFVDEASRVQLKGKVACEIHSADELVLTELILENVLAEYEPEEIVALLSAFVFQEKTENEPNLTPRLEAGKEAIIAISDRVNDLQIKHQVVLSSDDANDFASKPRFNLMEVVYEWARGMTFNRITDLTDVMEGTIVRVISRLDETCREVKNAAKLVGDPSLYNKMQLAQEMIKRDVIFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKY0</accession>
    <name>D4DKY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018158.1">
        <property type="nucleotide sequence ID" value="XM_003018112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKY0"/>
    <dbReference type="GeneID" id="9579448"/>
    <dbReference type="KEGG" id="tve:TRV_07854"/>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="270" mass="28685" checksum="EE5A287DFCA85F15" modified="2010-05-18" version="1">MSSTVHVANISSKTSEKEVRDFFSFCGKITSLSLTPSSGDAEATQSATVTFEKETAAKTALLLDQTQLGPSAVKVTAAPSIDDLAGEKATTAHGARDEASNHLEQEDKPRSRIVAEYLAHGYAISDQAIEKAISLDKTHGISARFNAVLKNFDSKYHATDKAKGIDESYGISDKATSGWRGLSSYFEKALDTPTGRKIRAFYLQSDKQVRDIHNEARRLADLKHASSPSPESAMGQTAQTTEGAPTAPTGVPVGDPSAPKTVPGTAAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL87</accession>
    <name>D4DL87_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000495">
        <property type="protein sequence ID" value="EFE37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018037.1">
        <property type="nucleotide sequence ID" value="XM_003017991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL87"/>
    <dbReference type="GeneID" id="9579163"/>
    <dbReference type="KEGG" id="tve:TRV_07961"/>
    <dbReference type="HOGENOM" id="CLU_096896_1_0_1"/>
    <dbReference type="OrthoDB" id="4483229at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="204" mass="23269" checksum="6E40416006A7A795" modified="2010-05-18" version="1">MSDRQHQEEDHTYNDIEDRVSECITMYPVFCTAKIPSDILDESIDESYAVIRDVIGEGGLPAYGMAPCILQTTDLDSITHGSRKPMPVDFESPFLNWTDEQVREWATKALRPGHLSFAQRTFTILDQSTVDNKVCRVGYISVFEEDEDYGMLSEVFYADIMARVPVELAEIFWDETLLSVGENGVLDPVEERTWAEKSRKEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC3</accession>
    <name>D4DLC3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017993.1">
        <property type="nucleotide sequence ID" value="XM_003017947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC3"/>
    <dbReference type="GeneID" id="9579121"/>
    <dbReference type="KEGG" id="tve:TRV_07997"/>
    <dbReference type="HOGENOM" id="CLU_023804_0_1_1"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="423" mass="47058" checksum="97473418CA1B8E4F" modified="2010-05-18" version="1">MALFGTQNQQASAPSLFGQSTNQPQQTGSIFGTQQQPQQQGSSLFGQSLQQKPQSNLFGGIGQQQKPSPFSGFGTTAQQQQQQQPQQTGGFTLGSTTTQQPQNQQNASPFAGFGTTQQQQQQPQAQTGNTFSGFGAPPQQQQQQQQPQLGQTLGFSQAGSSTIWTPGQGMTGVHRTVPMQIMIVKDKWDATNRSSPFRGYLYNNVGEESAPFFQPGPNDDENKWEEALRKRPGPGYVPVLVQGFWELGKRTQRQKDFLSMMQTRLHEINNALTELLSRHDLAISVKIAACRRKHKVLSQRCLALASKTQLLRNRGYAMDQTEEELAKKLFQLERAVFDPSLNGRSEEIWARMLAIRENSKRLQLEIERTGNDTSNQADDSLDDAALKTAKKILEDYATQIQHLNKELASVQKDFGNLEQSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLK9</accession>
    <name>D4DLK9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_08083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017917.1">
        <property type="nucleotide sequence ID" value="XM_003017871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLK9"/>
    <dbReference type="GeneID" id="9579795"/>
    <dbReference type="KEGG" id="tve:TRV_08083"/>
    <dbReference type="HOGENOM" id="CLU_351584_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="76630" checksum="531525228DA6A757" modified="2010-05-18" version="1">MRATTLLGENLVSQYICPSCSWRIVGFNGARGPSIKHSQASRNQLQAIHSSSRPSLRKLRPSSKSSTPKWKFITTRFVHSAVQSKEPQDNSFDTDQTSLPSNNDKDAWEIETPGSKRKDSTQDAIRKREEYIRAVLLEGQPDKVMAIFLDPGNNDYIMRQLPATTFIEALRLLSPAYFVEPWRKIQRSFHSSAAEYAKVEPLAQIFDRFARNLGTIVEARRRAGHTLGLAEYTHLLDCARSMGDEAMANTLWEEMIADGISPDVLCYNYYMEAKVWNMAFIPKENHSLRSTPWIYRKRRFKRSNPGYRGYKTGKDGVRDEVHSLFKDMVVDGLDANESTFIQLMIASGREWDIAAVKDTLKTVWNIDADRLQKGEEDLPPVTPYHPSSPLHPTDELLLAVAHIFCTNNDIPTALQLVDFISVNYNVPIPQRTWMELFVWSYILSTNRYGQNAEDNMIGHIPKDSVIGIFKTMTSEPYNMKPTLQVYDILTKLNWSRQAVDPTEGFMRDGRKMFQTTLSKRRVLAKQLIQAWKDLELENNSPSSESSSNLEQTATSSLRRVNPLSLTPPPTAPKAYWDLYHRFQVVHMATCRELDYLQTWALFMLLRRRWTGTKYDWERRGLPNTVNEWKIFLPRIVRYHITNGMVEFDPAQFWGDDRPVRATLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLN0</accession>
    <name>D4DLN0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_08104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000514">
        <property type="protein sequence ID" value="EFE37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017893.1">
        <property type="nucleotide sequence ID" value="XM_003017847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLN0"/>
    <dbReference type="GeneID" id="9583786"/>
    <dbReference type="KEGG" id="tve:TRV_08104"/>
    <dbReference type="HOGENOM" id="CLU_008891_0_1_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="33473" checksum="4E62B92C1B61D375" modified="2010-05-18" version="1">MNGPDIDEVRYFADRDIFCAGRVSSDDMERVNKATGASTQSTCSDIQEHHLGECGSFEERQIGGERFNIFSECPGAKTCTLILRGGAEQFIAEAERSLHDAIMIVKRALRNTNVVAGGGATEMDLSGYIHRYADVNVPHKQQAVVKAFAKALEVIPRQLCDNAGFDATDILNQLRVEHKKGNVWAGVDFDREGVRDNMKAFVWEPSLVKVNAIQSAVEAACLILSVDETIKNEESAQPQGPPQALPQGAAQRKKKKKQQAREAEDDELHAFLHYGVRMAQMKKKKKRLDFSLLPIIEDSIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLR0</accession>
    <name>D4DLR0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin/FtsZ 2-layer sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_08134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000518">
        <property type="protein sequence ID" value="EFE37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017839.1">
        <property type="nucleotide sequence ID" value="XM_003017793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLR0"/>
    <dbReference type="GeneID" id="9583753"/>
    <dbReference type="KEGG" id="tve:TRV_08134"/>
    <dbReference type="HOGENOM" id="CLU_015718_6_0_1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="192" mass="21693" checksum="851F176A236F2003" modified="2010-05-18" version="1" fragment="single">TNLVPFPRVHFPMFAYAPIAQDSRATHETNTIREMTLACFDPSNQMVKCNPQNGKYMATCLLYRGNIVPKEVHAAVATVRTKQTIQFVDWCPTGFKIGICDKAPEHVPNGDMAKTDRAVCMLSNTTAIGEAWTSLCHKFDLMYSKQAFVHWFVGEGMEMGEFAESRENLAVLERDYQEIANAEGDEEPEQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYY4</accession>
    <name>D4CYY4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_00021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025818.1">
        <property type="nucleotide sequence ID" value="XM_003025772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYY4"/>
    <dbReference type="GeneID" id="9582061"/>
    <dbReference type="KEGG" id="tve:TRV_00021"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE45207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="342" mass="37298" checksum="10C4182A8E7CAE95" modified="2010-05-18" version="1">MTLCETIHNFRFEPPAGWASIASTFVAAVGGLFLASQLFGVLRAFFSIFVLPGKPLRSFGPKGSWALVTGASDGIGKEYAHQLARAGFNILLVSRSADKLAAVAGEICEKNASVQTKTMAMDFSHNDDDDYEKLKKVIKGMDISILINNVGLSHSIPVPFVLTDPEEMEDIITINCLGTLRVTQLVAPGMMERKRGLILTMGSFGGLFPTPLLATYSGSKAFLQQWSSSLGSELEPYGITVQLTQSYLVTSAMSKIRKTSMTIPNPRDFVRATLGHVGRSGGLFSYAYTSVPYWSHALMAWSIVTFLGPISKTVIGFNKSMHESIRKRALKKRERESGKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ07</accession>
    <name>D4CZ07_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025782.1">
        <property type="nucleotide sequence ID" value="XM_003025736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ07"/>
    <dbReference type="GeneID" id="9582025"/>
    <dbReference type="KEGG" id="tve:TRV_00044"/>
    <dbReference type="HOGENOM" id="CLU_1152455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="241" mass="27638" checksum="ABEF06BC09834E74" modified="2010-05-18" version="1">MKEQQDNDNKMTNNNNSRRRRRRANVKSNVRQSAGEEDAKLSNAQTAETQAAFKPTSAARRPDRHPIQVQPPRPDKRKTKEGIEPEEKQQAEKKKKKKKMATDRWASEYYTRSAGGETAVAHFLFFLYIPICSILDKEERLARGKALRLHLSNPTWHFLAFHYSFQSIGLELSAAPVTLREKEAKEKEKEEYQIYSKKSSKKGGNKQVGEKAYRTSGRRKGAENEVQKGKLPPVPTLPKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ93</accession>
    <name>D4CZ93_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025716.1">
        <property type="nucleotide sequence ID" value="XM_003025670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ93"/>
    <dbReference type="GeneID" id="9581959"/>
    <dbReference type="KEGG" id="tve:TRV_00130"/>
    <dbReference type="HOGENOM" id="CLU_2607746_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="8883" checksum="7776A0826FF973C9" modified="2010-05-18" version="1">MLFFTFGLNNQPAVGPWSLSKTMIPSSRAAEGVCQANAHENKQWDRYTMQELAAGVSSDPETGLYDFYIYSLRESGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZC5</accession>
    <name>D4CZC5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025644.1">
        <property type="nucleotide sequence ID" value="XM_003025598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZC5"/>
    <dbReference type="GeneID" id="9581883"/>
    <dbReference type="KEGG" id="tve:TRV_00167"/>
    <dbReference type="HOGENOM" id="CLU_1908212_0_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="133" mass="15223" checksum="5ED0C10460A1DE5A" modified="2010-05-18" version="1">MITAEKKKGREYERLVSDEAEDIYPELIQSQRRWGARRVMEITVYTAVISVIALALGLFIGTSWPSSRHIGLDGYLGEEYTYLSVEYWPSGHADSYSSINYWQSPQAQFRGHGIATTHSRRFPPRSQRKHGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP9</accession>
    <name>D4CZP9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025529.1">
        <property type="nucleotide sequence ID" value="XM_003025483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP9"/>
    <dbReference type="GeneID" id="9581766"/>
    <dbReference type="KEGG" id="tve:TRV_00291"/>
    <dbReference type="HOGENOM" id="CLU_057572_0_0_1"/>
    <dbReference type="OrthoDB" id="4172847at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48664" checksum="EF16AD084C77DDA3" modified="2010-05-18" version="1">MKDSLSNSPPSKLQKANTIGQLDDVGGGYTSDSAGSSNDSLFFSETSRSTKRQRQMATRKKNSNTSETPEKGGKKRVASASAARQEVIPEKRQKTVEPVEPVERVDETAALPVRSMFSFVYIFSGFDYIFFFIFFLDLTTMRETQKHADKMNRNPFKTTVRFIIGPDEEEFQVHSFLLESTGLSGFFDLGKSTGPVKRPDLDSKAFTDLVEWLYGAHMRPGVAVDTAAKYNNLIDLYSIGQKMGGESWMRLVMKQMLELFDQTGRKVPAELASVVYEKFAWGSGMRRLWVTLNVVGEMEGECANVDFLRDVNRMQRSVIQKEKIDMENLLEPFRQQKKPPGPKPQPVSGESSTSQNGTTAQLAKGLVEKQRQQQEKQSQPRSQPETASQLNGEGRTQASSASTPQSQRSQKSRGLTTCEDLLRKFQSGQPKDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZS2</accession>
    <name>D4CZS2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_00314</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025552.1">
        <property type="nucleotide sequence ID" value="XM_003025506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZS2"/>
    <dbReference type="GeneID" id="9581789"/>
    <dbReference type="KEGG" id="tve:TRV_00314"/>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="18">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="19">
        <location>
            <begin position="190"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE44941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="412" mass="44952" checksum="0918CAD0E01FADAA" modified="2010-05-18" version="1">MVVEAPPCPQSGNGFANGSAKPKAYRDEAERRRYEHHEADVVIIGAGIAGCTLAVALGNQGRSVILLERSLKEPDRIVGELLQPGGVRALEQLGLRDCLEGIDAVRTYGYDVIYFGNGVKIPFPSDANDKILEGRCFHHGRFIMRLREAAAANPNVTIVETKAVSTIKSTHTEDVLGVQCQTDGKQDFYFAPLTVVADGYASTFRKEYLPIQPVAKSKFWGLELIDAKLPIPGHGHVVLGDFPPILIYQIGEHETRILIDIPDNLPSASVANGGVKGHMRNVVLPSLPECIQPSFEAALEKGGFRSMPNSFLRPVTNRIPGLMFLGDSLNMRHPLTGGGMTVAFNDVVLLRDLLSPEAVPDLSDTKLVLRQLSKFHWQRKSLISVINILAQALYSIFAAGGKHIFFPPFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZS5</accession>
    <name>D4CZS5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025555.1">
        <property type="nucleotide sequence ID" value="XM_003025509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZS5"/>
    <dbReference type="GeneID" id="9581792"/>
    <dbReference type="KEGG" id="tve:TRV_00317"/>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="297" mass="33243" checksum="FC447FECF551DC06" modified="2010-05-18" version="1">MCKILDKISPETAPHKPYVAFRYAAPLTEEMYTQLLNDGFGKGKGGRAVAFTQYPQYSCSTTGSSLNDLWRWKNKLEGRRGAEGSEDVSGNIQWSVIDRWPTHPGLIEAFAQNIEAQLATYPEDKRDNVVLLFSAHSLPMTVVNRGDPYPAEVAATVYAVMQRLKFSNPYRLCWQSQVGPQAWLGAQTSDTVQNYVSRGQTDLLLIPVAFTSDHIETLYELDKEVIHEANNPGVKRVESLNGNPVFIQGLADLAAEHLRSGAKCTHQMMLRCQNCTSERCLEQKKFFAGPEGRDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D062</accession>
    <name>D4D062_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025395.1">
        <property type="nucleotide sequence ID" value="XM_003025349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D062"/>
    <dbReference type="GeneID" id="9581631"/>
    <dbReference type="KEGG" id="tve:TRV_00456"/>
    <dbReference type="HOGENOM" id="CLU_005281_0_0_1"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="409"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="85160" checksum="FD0D0718FCE07DDE" modified="2010-05-18" version="1">MADEDESRRKRIKVSNGDSGSESLAAPIQGLVGATVDAGSPAPDAQAVKEAEVGITQFVSPGLPGFSGVVKKRYTDFLVNEILPSGEVLHLKDTELSTALKTAIAETATPVESASATPQDTPVTGEEIEGKTGEVEDDKTEKPAAETAGIVLADLATEDRELLDQLFGPETTPKLLNLYSRAVAKASSRPGELGKVKSLVITDKDQRTSLHQAIRRIFKSNLDSTTDSDGTIVVSAASVQQRGGGKGKRKKQSGRDRGQGASQLPRGKLGWSELGGDYLHFTLYKENKDTMEVISFLSRQLKVAPKAFQFAGTKDRRGATVQRVSVFRIYPDRMPKLNASLRMAAIGDYEYQKQGLELGELNGNEFVITLRDCQFPEGVVDRGNISSPETIAKVTELVGKSLCDLRERGYFNYYGLQRFGTFATRTDTTGLKMLRGEFKEACESILHYSPIALAAAQDVSSEDPSQRPQISTDDILRAKAIHIFQTTGNGRDALEVLPRKFTAESNIIRLLCQRKNDYFGALQSIPRNLRLMYVHAYQSLVWNFAAGERWRLYGDKVVEGDLVLVSEFKDETKAAAQQAEVDADGEEIVLPDADDSAAVDDMFERARALTAEEAASGKYSIFDIVLPLPGFDILYPANKMTDFYKEFMGSDKGGNLDPFDMRRSWRDISLSGSYRKMLSRPGADYSFEVKPYRAEDEQFVKTDLERLRENTSKSADGNNDNNQSSLTSETLEQPEKLAVILKFQLGASQYATMALRELMKTGGAKEYKPDFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D094</accession>
    <name>D4D094_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025309.1">
        <property type="nucleotide sequence ID" value="XM_003025263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D094"/>
    <dbReference type="GeneID" id="9582951"/>
    <dbReference type="KEGG" id="tve:TRV_00489"/>
    <dbReference type="HOGENOM" id="CLU_049413_2_2_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="30000" checksum="8E08061C6224940B" modified="2010-05-18" version="1">MAFPDLHIVEPKGAHMHTIILLHGRSSDGPEFAEELLDSKTSEKKTLTARFPNCRWVFPTSRDRWSSVFQEDLTAWFDIYSLSNTSEKQDLQIDGLRETILYILGVMSQEIDLLGGRPEKVVLGGISLGMAAALWVLLCSPGRFKGRIGGFIGMCGWLPFANEIQDLQHPREMIPKFLLDTVRCEEQVQTSTIDTETMLSTPVFLLHGSDDTWVDVELGRAAHRGLLKLGMKPEWKEYVGAENNGHWIKQPGGFDAIVQFLEAVWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0H2</accession>
    <name>D4D0H2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000032">
        <property type="protein sequence ID" value="EFE44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025251.1">
        <property type="nucleotide sequence ID" value="XM_003025205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0H2"/>
    <dbReference type="GeneID" id="9580743"/>
    <dbReference type="KEGG" id="tve:TRV_00567"/>
    <dbReference type="HOGENOM" id="CLU_068529_1_0_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="281" mass="31494" checksum="354DDF8CEB463DDA" modified="2010-05-18" version="1">MHKSIPSSAVFRRIGPTPARQPFGQTYSRIAQRDKEQCLLCQNGLYRRLTHSQSRKFNTLRSLSFQSPLPRAAPNRAEPASQPTSEDISPGLATRVPDITTHYTIFPKTLPKGPPPKGTFDISLPDLRREFLSLQGLAHPDKFPEGPAKRKAEALSSRINEAYRALGDPLARAQYLLASQYDIDVTAEDGANKHPQSPETLMQVMEVQEAVEEAEDEKVIADLKVENEERIAQTVNEMGKAFESGDIDTATKLCSKLKFWYTIRAGLREWEPGTRSVRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0R3</accession>
    <name>D4D0R3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025176.1">
        <property type="nucleotide sequence ID" value="XM_003025130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0R3"/>
    <dbReference type="GeneID" id="9580669"/>
    <dbReference type="KEGG" id="tve:TRV_00658"/>
    <dbReference type="HOGENOM" id="CLU_437547_0_0_1"/>
    <dbReference type="OrthoDB" id="4169972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="625" mass="69977" checksum="6C7E4F03F454F934" modified="2010-05-18" version="1">MAQSPSATGSTDVPISPPPQANGVSHAPSVASSTAQSVTPNGHEFGNQSEGAESTARSSVPSNHGAGFVNSNHEDDHEMDFKSGYNAVSKEEPKEFVNTDADAKQMPGIPEILEMLATMERKFQQMEARMDQLVPPPVDEPPSISQIPRYVHNPEIIDRSINAEVPVEDTITAFRSRASLVARAKVLHMAKKFPDWKDRVFEQAKAATCLPILEDGQEVCPPDSQVHPKLWEVQNEWLYDFMYESIGPQFKDEIFEPPNRSAYLLWRQIESYCSLVNEDDRRYLIQKLMTINAKNDFDYISTFYRYYSKIRKLGFIIPDWMAQDLLYLRVSERAREMIQNEIDAARNAKDGPLTLSVDKMVARVLRPALSRGANEEEPQPEPTPSVTSSVANGPHSAGSKPDSLNASSSQAETIDKKGKVTCGYCSMPHHSEDGCFYKYPERTSPAWQKAHKSGIEFFRKKAEGREQPDSKELQSVTQAVKKIQIAQKPQSEAVSESKTKTPAKPESVAGSKMEARPEPRQEAVNTQPQVKSPEIYSEKLSCNYCGQKGHSANGCPFQFPDLETADWRQKNKHLIEFHARKDKLRKRKLERLKAKQALEGSKPDTPSAPNAPRPVSPENLLILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Z7</accession>
    <name>D4D0Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025085.1">
        <property type="nucleotide sequence ID" value="XM_003025039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Z7"/>
    <dbReference type="GeneID" id="9580565"/>
    <dbReference type="KEGG" id="tve:TRV_00743"/>
    <dbReference type="HOGENOM" id="CLU_998159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="31401" checksum="E48133B002C66BA4" modified="2010-05-18" version="1">MDEHEQKGEGRGTAGEEQTRREAGSFASRCCFFFFASFFFFFVGGEEAPRRVSIQAAGRTDKQKTERQAETAARAHKGREAKRYLAKGLRFLAGFLAASSNEELHEGGQVGPHWVRAQVQRAKGQQAHPVCLFTAGLTSYGRRDGRIYEYIGRALDETDSMKRQSTTGARDEGRPTELSALRTLYIYRQTSSRHLTAQRPQEAKQKGTRKHIYKLNQGTHAFVDRAGPLSWLSSSVVHRDLHHVDRDGDGTILYRPLDQGLGNKKDEEGDEDGNLLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D8</accession>
    <name>D4D1D8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024967.1">
        <property type="nucleotide sequence ID" value="XM_003024921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D8"/>
    <dbReference type="GeneID" id="9580459"/>
    <dbReference type="KEGG" id="tve:TRV_00888"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="161" mass="18617" checksum="1CB11AE63EA445C5" modified="2010-05-18" version="1">MATIRRMTPGDLLSLNLTNLDPLTENYDLHFYLNYLMKWPSLFNVVEDRDGQIVGYIMGKLETQPQAMRHSEHYTPWHGHITVLTVAPAWRRMGHARRLTESLERASDKNNAWFVDLDDPTGLSEEGEDAFDMRKPLSRDVHLKHSRPNGENFLVSPEDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F6</accession>
    <name>D4D1F6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024901.1">
        <property type="nucleotide sequence ID" value="XM_003024855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F6"/>
    <dbReference type="GeneID" id="9580392"/>
    <dbReference type="KEGG" id="tve:TRV_00906"/>
    <dbReference type="HOGENOM" id="CLU_022332_0_0_1"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="57"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="412" mass="45394" checksum="23C465EEAA763FB7" modified="2010-05-18" version="1">MGEQEKARTSGEIQPGAAAGPAMAMEMEDRKDDSQTLPTVNPAATKNEPPKPSFHPAFYVISWITMSSAVILFNKDLLDKKQNKFPVILTTWHLAFAAFMTQVLARTTNLLDGRKKVKMTGRVYLRAIVPIGFFFSLSLICGNKTYLYLSVAFIQMLKATTPVAVLLVTWALRISPPNMKVLMNVSFIVIGVIIASFGEIHFVMVGFIFQIAGIVFEATRLVMVQQLLSAAEYKMDPLVSLYYFAPVCAVMNGVVALFMEVPDLTMDHIYKVGVITLLANGMVAFLLNVSVVFLIGKTSSLVLTLCGVLKDILLVTISALWWKTPVTPLQLFGYTIALGGLIYYKLGVEKMKEYTNQGLRQWAEYSSTHPARSRLILIGMGVLVLIILMFQFGGSVDPKVVKGMLPGKVSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X6</accession>
    <name>D4D1X6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024729.1">
        <property type="nucleotide sequence ID" value="XM_003024683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X6"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="GeneID" id="9580219"/>
    <dbReference type="KEGG" id="tve:TRV_01078"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="357" mass="39526" checksum="436C49092E16ADE1" modified="2010-05-18" version="1">MPATTTDTLSLVTTTVTVAPLVLLSAADHYGRSAKGTRKRVVGVLLGQNDGKTVRVSNSFAVPFEEDDKDPSVWFLDHNFVESMNDMFKKINAREKLIGWYHSGPKLRASDLEINELFKRYNPNPLLVIIDVQPKEVGVPTDAYFAVEEIKDDGTTTSKTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGQYLEKVLDRDLPVNHAILGHLQDVFNLLPNLATAKPGTPSGANGAEQQIENTELARAMNIKTNDQLMSIYISSLIRAITAFHDLIENKIQNRQQQEEREAKKEEGKEEKAGASSNNENKKSGSASGTDTKDEPSSNEKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D201</accession>
    <name>D4D201_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024754.1">
        <property type="nucleotide sequence ID" value="XM_003024708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D201"/>
    <dbReference type="GeneID" id="9580244"/>
    <dbReference type="KEGG" id="tve:TRV_01103"/>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="812" mass="92608" checksum="9DBB666F56EA3A67" modified="2010-05-18" version="1">MRFGKTLQTSVYPPWKDHYIDYRALKKLLREHEGSEDGDEGEGRPWTDEDEENFVQELINVQLDKVNSFQVETHKRLRELTAECEAALEPVAAQQGEAKLENVKKNEAVAQETLSKLDRITEELGELEKFSRINFTGFLKAAKKHDRKRGAKYKVRPLLQVRMSQLPFNSEDYSPLLYRLSAMFSFVRSILGTEGQPMPKDGPAVDTQTGRETYTSHKFWVHADNLLEVKTYILRRLPVLVYNPNTSKELDVAQRDPSLTSLYFDNRSFDLYNQKVANKPAAGSLRLRWTGHLSDQVEVYLEKKIMNDGDSSREIRIRLKKKHINAFLNGSYKMEKIIHKIEIQGNGDPQRADNLKRDVEEIQEFIKSHGLEPMVRANYTHTAFQIPGDDRLRISLDTDLALIREDTLDFERPCREPEDWHRPDIDSRRMEFPFSEIPRGEISRFPHALLEIKIRNTSGKRRGSNVEAWLSDLMSSHLVKEAPRFSKFVHGVAQLFEDHINSFPFWLSDLDTDIRQDPETAFQQEQERIAKQAEDELAVGSFLGSRQTIPSIQHLVGSPISHMMTEESTPKTQIRIQGVVQPTSPRPEALSQSQSQSELTPRAPIPELSLPPSTEQANGAQPQPSSRPTSSLLRIPFSMSRYALAHRSPQPQLPSGVSMPSYWLKDTGPVRVEAKVWLANQRTFVKWQHICILLAGISLTMYNAAGPDKTITRYLALVYTGFSIFTGAWGWWMYESRSRLIRERSGKDFDNVIGPLVVCLGIAVALVLNFWFKYASIVWADPAPNAPSPTGNIAEAAPFMTARPQFQAQPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D230</accession>
    <name>D4D230_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024725.1">
        <property type="nucleotide sequence ID" value="XM_003024679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D230"/>
    <dbReference type="GeneID" id="9580215"/>
    <dbReference type="KEGG" id="tve:TRV_01132"/>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="895"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113519" checksum="14B23D3AC5BDF570" modified="2010-05-18" version="1" fragment="single">VQQQLQLQHLADGPGSTTVTRSVTPDSQTGDLLCSRAVSQNMEKNAPTPPADEAPESSTAAQQPILPRDRQARTATYDYAYEKSMSHAEARLFYQRHQLASRSVDGDIPQSPDIPARSIPALPNHGPTSGSNFDNESISSMLPGPSYSATSTPPANSQQMRRENSSFSIAERSARAHVLPTVGMPGDASHSAIQGNVGMSVGTGIPYAMGGYAPNDGAITAELSAICRKIQGLLDTRHKYMRLSFQRPGDNPKDEPGWVIYPPPPEPAWEEDKERLGTGSMSSSFVMAAKGGSKQGESDVAPSASSAKKKRKPGQDIGEDFDMDDLLPLPEASSMTFKLDDNSVYQVYETKAACDLNQPVIQIPSIRDFYMDLDGVLDVSTDGPVKSFSFKRLSYLEGKFQLHTLLNEYQELADSKKVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKMKKCPDEVVLFRDGKHLTLKEVFESINLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPIGESRLREIFLKTDNYIKGRYLAEITKEVISDLESSKYQMAEWRISIYGHSLGEWDKLAAWVVDNKLFSPNVRWLIQVPRLYDVFKSSGKVGNFEDIVRNVFQPLFEVTQNPNSHPKLHIFLQRVVGFDSVDDESKAERRLYRKFPVPKQWDTKQNPPYSYWIYFMFANMASLNTWRKQRGFNTFVLRPHCGEAGDPDHLASAFLCCQGISHGILLRKVPLLQYLFYLDQIPIAMSPLSNNALFLSYDKNPCANYFRKGLNISLSTDDPLQFAFTKEPLIEEYSVAAQIYKLSAVDMCELAKHSVDQSGFELALKQRWLGSKCHLPGLEGNNMAKSNVPDLREAFRYETLTGELSLLDRYASATPNNTHTPKTLTKVPSFSYLKNNNNNNNEEAPSSSAAPGPSSGAPEHGSATPAAAANTPGRHPSHSDVESHAHSSKPQTASGTPQEHGFSSMPAQAIFPGIVHARARKDSTFSRTSEDGAASEDAHERSSAQGGHIWRSEDMDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D263</accession>
    <name>D4D263_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6 finger domain transcription factor nscR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Neosartiricin B biosynthesis protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024702.1">
        <property type="nucleotide sequence ID" value="XM_003024656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D263"/>
    <dbReference type="GeneID" id="9582877"/>
    <dbReference type="KEGG" id="tve:TRV_01165"/>
    <dbReference type="HOGENOM" id="CLU_004083_7_3_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="721"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="815" mass="91686" checksum="4E98183E0BABA1A2" modified="2010-05-18" version="1" fragment="single">MAQPETPKQWEKNVGGSAPVSQQLAPNTYASETALTSPEADVVTKSGSQLQQNESASDSTSPAFLQAATAAPPEASPNPRSCVTCRRRKVRCNKHHPCSNCIKAKIECVYPSPGRAPRKPKKPRDTELLARLRTLENIVKNLGGPDAIHGNPSSLSLKKPPLHQNSAIEQPKDYANTSDAMQQDATVKSEAPDTSEIEENMGKLMVEEGGSQYFWENGAFISPFSMATHFLQILIVQILTCPKVDDLKSILDPLSSDNENDTVEESAFDESYGVNHDGFLFGFSSLAQSLRDFHPPPNQVDILWETYLQNIAPMVPIFHTPTLKPALYHGIKNLDSLDKNTEVMMLTIYYTSAASMSAAECLARLGEPRDIVLGRYRFAVEQALGRAKILHSGSFTLLQGLVLFLLCVRQHDDTRYVWSMISIAYRIAQGLGLQRDGTNFNLSPFETEMRRRLWWHICILNFRASEDYGCDPFIYESSYDTRMPLNINDDDISPDSVDFPEEKEGCVETSFFLIRCEIAVVNKRLSFIPPSSSCRLQVSRYSMAEREELIDKLSSNLETRFVRHCDMTIPIHWVCATVSRLVIAKLWLMIHQPMVQKSQRNPIAKETHDRLLMTSVEILEFSRLLETNVNTAKWGWLFRTHMQWHAVAFLLSELCVRPLCPGVDRAWRAINSVYEAWNMHSEKKNGMLWPAIRKLMARAVKFREKQLHQLTLQRGKQDLDIPGSCAATPSTDPSSTYLTSSSSPPQYLREPTSYSSLSSDMHIDNNTLNQNYNLTTIPQLGTALETQWADPAAITQVDTSILSSASPSWSDWDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2G1</accession>
    <name>D4D2G1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024554.1">
        <property type="nucleotide sequence ID" value="XM_003024508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2G1"/>
    <dbReference type="GeneID" id="9579777"/>
    <dbReference type="KEGG" id="tve:TRV_01266"/>
    <dbReference type="HOGENOM" id="CLU_005679_13_3_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="57"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="485" mass="55545" checksum="980B3EE0DC17C1A0" modified="2010-05-18" version="1">MSALPGNILEKQYWQEPTGAESKPSRLSGALRWFLDIVRPSILTTKGRRKQMGRTSYLDGLRGFAALLVYFGHHELWAHDAITQNPIFENAYGYKGKHHFIALPGIRTFFSGGHFAVSVFFVLSGYVLSVKALSLIQAGDYLKLGDTLASALFRRWLRLYLPVMATTFIHMTIWHMFGITAVPDPQGSYKDEVWKWYCEMKNFSFIYRTGGEPWFHYNFHAWSIPVEFKGSIVIYTALLAFSKASRNARLLCEIGLFIYFMYIADGALCAMFVAGMHLSDLDLLAESNNLPRFFYRLQPYKETFFYSLFVISMYLGGCPSHSFDVALLKESPGWNWLSYLKPQAVFDFKWFYLFWAAVFLVSSISRIRPLQSFFELRFNQYLGRVSFALYLVHGPVLWILGDRLYSAVGWVKDSHHKTIPGWINRFPLPTNGPLGLEVGFLAPQLILLPLTLWLAEIVTKLFDGPSVKFAQWAYSKTLPPAAKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2S5</accession>
    <name>D4D2S5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024418.1">
        <property type="nucleotide sequence ID" value="XM_003024372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2S5"/>
    <dbReference type="GeneID" id="9579640"/>
    <dbReference type="KEGG" id="tve:TRV_01381"/>
    <dbReference type="HOGENOM" id="CLU_085752_0_1_1"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="167" mass="17394" checksum="22C9F262003B8E77" modified="2010-05-18" version="1">MLFNGEGEAFNVGLFLETVSPYAFANIGIGLGIFVTGSSIIGGGVRAPRIRTKNLISIIFCEVVAIYGVIMSIVFSSKLSYVSEESLYSGSNLYTGYALFWGGLIVGSCNLICGIAVGINGSSAALADAADSSLFVKILVIEIFSSILGLFGLILGLLVAGKANEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2S6</accession>
    <name>D4D2S6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024419.1">
        <property type="nucleotide sequence ID" value="XM_003024373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2S6"/>
    <dbReference type="GeneID" id="9579641"/>
    <dbReference type="KEGG" id="tve:TRV_01382"/>
    <dbReference type="HOGENOM" id="CLU_2250632_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051920">
        <property type="entry name" value="MPT_Adenylyltrnsfr/MoaC-Rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764:SF1">
        <property type="entry name" value="MOLYBDOPTERIN MOLYBDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="3">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="107" mass="11834" checksum="23FF6E9643965FAA" modified="2010-05-18" version="1">MSDQRFRAAILIVSDTAARDPSTDAVGGILTDVFSQHDRWEKPTIAIVPDSILEIQRHISRWSDGNDHFNLIITSGGTGFAVRDNTPEVGCSPDFYRTSNMKKIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Y3</accession>
    <name>D4D2Y3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit of the cohesin complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MCD1</name>
        <name evidence="7" type="ORF">TRV_01439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024373.1">
        <property type="nucleotide sequence ID" value="XM_003024327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Y3"/>
    <dbReference type="GeneID" id="9579512"/>
    <dbReference type="KEGG" id="tve:TRV_01439"/>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="527"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="602" mass="65725" checksum="77D22B36A5D68F23" modified="2010-05-18" version="1">MFYSETLLSKTGPLARVWLSANLERKLSKSHILQSDIESSVNAIVDQGQAPMALRLSGQLLLGVVRIYSRKTRYLLDDCNEALMKIKMAFRLTNNNDLPTTAPLPAGGITLPDVLTESDLFMNLDPSILFTQPAQVEHDPKRPASSLGWSSQLLPDSTPQTVRPVEKPHLEDDTGLILDLGEDEDIPLGHDTSIEVGREAPAPRPVGEDLFSDDNRLYDGDLNLDLGEDGAPLGKGPDADVTHDIDNAIHMDDDIPMGGIDGELGMPIEEDSTVIPPLTSDFTRDRSGSPLSSVRSSVVRDLDETFANEGAIRHHQRVKRRRVIMPDADTVLSSAQIKEQQEDRSKILIGESILPRDPVLLSLMMMQKNGSFVSNVMGGANTGNWAPELRGMLSIESVRKAGDLKRKRDSGIADMDIDAGAKVPRLDIEGEETLLQPDEGPILGEDTTLNLQPEIQVPEDEEHAHPRSGDDHFSEDEGLGQHPEEYDELSSLVETGPISLGTKHAVHVLREQFGESPSTESPTKGKAVVFQDLLPELQTSKADATKMFFEVLVLATKDAVRVEQSSKDLGGRLRIKAKQGLWGDWAETEAGGEIAPQEVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D330</accession>
    <name>D4D330_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024350.1">
        <property type="nucleotide sequence ID" value="XM_003024304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D330"/>
    <dbReference type="GeneID" id="9579489"/>
    <dbReference type="KEGG" id="tve:TRV_01487"/>
    <dbReference type="HOGENOM" id="CLU_021768_6_1_1"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="300" mass="34225" checksum="9BA9153185A2FCC2" modified="2010-05-18" version="1">MAQVDTTVDTTKEDPTPCPTCGWSDLRRSRCSHISQVKLVNAISNRAWWHIGSDMVLKEDPYDKWKTSEVANLKFIQEKTTIPVPTIVKDWVQSDNRHFLLMERMPGETLDTLYQKLSTAELEAIADQVAELIQQLRPLQSPQIGGIGGTPLHNGWIFVNNMEPAGPFSSDDELWDCMKNGLAKVPAKAVENLRKRMPACKPYTWTHDDLSSSNIVVKDGKVTGILDWEFCGYYPVWWQYVSAGSGDPEEERWLKIMHGKVKDQYPEATDFFRDLRSLTYYPDLTEHGKKTLEKLMADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D360</accession>
    <name>D4D360_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-trehalose-phosphate synthase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024319.1">
        <property type="nucleotide sequence ID" value="XM_003024273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D360"/>
    <dbReference type="GeneID" id="9579427"/>
    <dbReference type="KEGG" id="tve:TRV_01517"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000010">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="528" mass="59080" checksum="1107B5B0F8D6BCC3" modified="2010-05-18" version="1">MRAGENSVFYSYVKQLNSYSKMTESKTQGGRKPQLLVVSNRLPLSLKRTDDGKYESSKSSGGLVTSLSGISESIGFQWFGWTGLEISEDEQQEVQKLLAKQDAVPIFLNKELADNHYNGFSSECPVADVIYVAVAPTSPAIVAGTDDHSNLDSILWPVLHYQPGTQHFDEKWWHAYQEVNQVFAKVVAEATSDGDLVWVHDYHLMLLPGILRKEFAKQGKHSVKIGFSLHTPFPAAEVYRALPTNQELLEGVLNSDLIGFHTNDYAGHFAEACSQILGASKDGLTLRYKDRTIQVGKFIVGIDPTRFLEAVESEAVKKRIAELEDKYKGIKRIVGVDRLDYIKGLPEKLRGFQEFLRTHPEWVGKIVLIQIAVPSREDVQEYQELEAELYRLVGMVNGEFGKPDYAPVIFIHQSIPFEELAALYAASDICLLSSTRDGMNLVALEYIACQKERNGVLAVSEFAGVSSYLEGGVKFNPFNSSEIARVIHDAVEMDTEQRKKEHARLLDFIKTHTSTHWGQGFVEKLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H5</accession>
    <name>D4D3H5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024202.1">
        <property type="nucleotide sequence ID" value="XM_003024156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H5"/>
    <dbReference type="GeneID" id="9579240"/>
    <dbReference type="KEGG" id="tve:TRV_01635"/>
    <dbReference type="HOGENOM" id="CLU_1983183_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="15075" checksum="A8068E20883AC745" modified="2010-05-18" version="1">MEEQADCATKGVLPSLSTAASHAFTALCVYSLHSLAITSSPSMYLFFIFFHLFYPFIPFYIPFFVFFVFFAFFFSFFSVMQKNKQKETKRRRRRRRRKKKKKNKDEEDEDKRDSHRQAPEETPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3P8</accession>
    <name>D4D3P8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein RO7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024150.1">
        <property type="nucleotide sequence ID" value="XM_003024104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3P8"/>
    <dbReference type="GeneID" id="9577147"/>
    <dbReference type="KEGG" id="tve:TRV_01708"/>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63868" checksum="E65AE3174CDCC53D" modified="2010-05-18" version="1">MAAAPSSTIDSERRQSLSSASIRGNLRQARGSIVSIPGSPHTPQQQRPILSPYTGTSSPGSSFRQEEDAVILEIGSRWLRAGFEGNSMPTCVTGFGTEEGRRVGDYRGWIRNNSSTVRKRLTYDVETWSKNYELWTSDLRGFDIQLFEDRIERAIREVYNKYLLTDAGSSRLVLVIPSIVPHPLLASLLSTIFHRWKYPSITLLPTAAMATVSAGLRSSLVVDIGWEETVVTAVYEYREIRSKRSTRAMKMMMHEMGKMLSSVIYEIEGSSLGGKESSVCIPFELCEEILVRMAWCEKSSQNSEDSEFMSAHSAPSTVSEGGNRDTYSRSLDSKVSVPLPIGSDSKYTEVPFSRFSQPTETTLFGGPYENRDWDDEDMPLDILIYYFLLSLPPDLRGTCMSRIVFTGGGANIPGVRQRILDDVNALVEKNQWSVSRGKSINKRKSRLYEQNGNGNSTPSNTDESNSAFREPPELESNFIDEKMDLKRKDDRYVHGVLRQVESMGPWAGASLLASLKIRGMVEIEREKYLQHGLAGASRDYELNPPDRRSGHGQGAVRAGGDRSSWTLGEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Q3</accession>
    <name>D4D3Q3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024115.1">
        <property type="nucleotide sequence ID" value="XM_003024069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Q3"/>
    <dbReference type="GeneID" id="9577128"/>
    <dbReference type="KEGG" id="tve:TRV_01713"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045178" evidence="1">
        <location>
            <begin position="16"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="379"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="699" mass="78430" checksum="47DE60E8508F1D82" modified="2010-05-18" version="1" fragment="single">AIAGLLLCVAGIASAVEPCGQVAEIQRERKKEDPDVTEFKIPANLAHACLLSVPFNVNNSLRLLDGLSYFWDSQSTKGWLPNPPKGYDLPPTDLDAGLEKIRQKALSGGYTGEYMFQLDLQTLVTSVHDGHFHMDLDLLTVFSFIRYDVGSLVSLSLRGKDFPRLYVLDDLKKSSKPSAIGNKHAIDPKSAVKTIDGEDSVKWMEEWSLNGGSQDRDALYNQMLAGLPRVPHRRRGGFRYPGSVYPGDKTTLGFYNGTVRDFSNWAFFDVSFTGVKDGETFYDKFCTGRDDESGVNRMGGLDYYFKESDRKTPRLISSPISNPQPPSRLAARELPPYVKPDVNSTDGIVEGYFLKNRFPRTAVLVVKEFIAKGNTTEMDLSYTIAAFLEQCRKMKTKKLIIDVSGNEGGLVFLGYDLFKQLVPNGKILTPSNMRATEQLNAVGTRANELLNKPLDPRAAEAENLRYSGYDLDTYITVDGTKFPSWPDLYGPEILPQDNYTHPTKWDLDNIKMTLATGPFIVSGYGNRTKIPPSPFSMRDMVIVTDGICASTCSIFTDLMRRHGSKFIAVGGRPQHGPMQAVGGVKGANVLTYRYLYYVIWLLYEKLSTVEERALLEKTRVGKMYHIGLYVLGRMATRGKNAAVNFRNAIWNEDKARTPRQFVYEPAECKTFFTPDALYDPLAWWTRLAKSWWGLKEICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4C5</accession>
    <name>D4D4C5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023890.1">
        <property type="nucleotide sequence ID" value="XM_003023844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4C5"/>
    <dbReference type="GeneID" id="9582490"/>
    <dbReference type="KEGG" id="tve:TRV_01940"/>
    <dbReference type="HOGENOM" id="CLU_2252013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="104" mass="11323" checksum="DDAAFD8640F34A3E" modified="2010-05-18" version="1">MRGCAGGDDAAGGVKLASKSLFEAHDDDLPDRAQTPKLRVSRASQTYNINDNININANANANDNDNDSPPNGQLRAGSNIHSNRSPSLKHTRNYAVCFFYLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4K0</accession>
    <name>D4D4K0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023820.1">
        <property type="nucleotide sequence ID" value="XM_003023774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4K0"/>
    <dbReference type="GeneID" id="9582395"/>
    <dbReference type="KEGG" id="tve:TRV_02017"/>
    <dbReference type="HOGENOM" id="CLU_1225548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="226" mass="25305" checksum="85B71FC9414AC19C" modified="2010-05-18" version="1">MGAGEQYRTCSLFGCDLLSDAISFEAAEPAEPHERRIVYEDTEEVKTGIGDKLGPRRCWARAAETRGRVSSGGRSIVAGLAEGELVFAIYRAGATASSWKSRDAARDVFLLIEAEQKVEKVEAGRLWGLFGWCLRKISKLRLKSKSEEDAEETTTFSQLITADRQEKKKGLDGREARSEAEVVQAIDELLERYLHLLDEQQKLQEAIGKQFASVRGGLFFFAWDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4P8</accession>
    <name>D4D4P8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathione S-transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000107">
        <property type="protein sequence ID" value="EFE43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023789.1">
        <property type="nucleotide sequence ID" value="XM_003023743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4P8"/>
    <dbReference type="GeneID" id="9582368"/>
    <dbReference type="KEGG" id="tve:TRV_02064"/>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="183"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="344" mass="38890" checksum="AC32F036473D7E62" modified="2010-05-18" version="1">MASLFVASQNEKTTLLGKTKQDYASILRWMCFANSEIVPYVGAWFRPILGKEPYNKKAVEEASARALKAFDVLEQHLTSNTFLVGERITLADLFTASLCYRGFQYVLGKEWRLSNPATTRWYETIVNQSVFKAVVSEPPFVEEPLKNVPPKKEEAAKPAPAPKVAAAAAAAPAEEEEKPAPKAKHPLEALPKPTMILDDWKRKYSNEDTRSVAMPWFWENYNPEDYSLWKVDYKYNDELKMTFMSNNLIGGFFNRLEGSRKYIFGAASVYGKTNDSVIQGAFVIRGQDYVPAFDVAPDIDSYTFTKLDASKPEDKAFVEDQWAQDKSITVNGKEYECTEGKVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4V0</accession>
    <name>D4D4V0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023730.1">
        <property type="nucleotide sequence ID" value="XM_003023684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4V0"/>
    <dbReference type="GeneID" id="9582298"/>
    <dbReference type="KEGG" id="tve:TRV_02117"/>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="369"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="623" mass="71108" checksum="B6F06C56C6174524" modified="2010-05-18" version="1">MQQRGQLGQRGPTVGTSSAVRSRSGSGSESRLRSGLNAASNALSSSMDSRHRSGGRLASLPQIPPRSSKVSEKLVLLPETVEEEEEEEEQEAEEEEEDEDDEVADDEGTPSKINERYERLRRLTAARAKQPDFTQDNMAAPLLDNEEAIRKRRFAASPEKGKSYAERLPKARRGKKLPRVTAYCTAQAYKMGAAASFVKELHDARTKLYDDCLYAAYHLPLLPGRDGYRVRSSPIFRSAEGKVVLDEEIARNERRDYHDEYFTETEEHSVRNSEEQERRERRREQERDREEEDGHERDHTHDHEVGAERSNGRRQEERDTPVRGHSFHVEHHDDQPSTQNGDIRQPTSPVSTRQSRPSIPPNALSFAEMFIFSYGVVVFWNFTERQEKEILADLAFCPAPNDLPLNPLAEEDFETEEFHFEYSSAISRPRVYNDMITLRSGDHMIKLAISHGIAQSTKLSFFEEGMARQMADAKDVPRRLALTGHLGMGREEVFRIMGRLFKSRVEVNLSSNMLDVPNFFWDSEPMLHPLYIAVREYLEIKPRIQVLNERCRVFLDLIEILSDSIADNKVSSQTWIIIILIFISIIVTLSEVVLRFGILSTKKGTQSKMLLDQGKANGMSIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D542</accession>
    <name>D4D542_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023637.1">
        <property type="nucleotide sequence ID" value="XM_003023591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D542"/>
    <dbReference type="GeneID" id="9582183"/>
    <dbReference type="KEGG" id="tve:TRV_02212"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_1_1"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="357" mass="38141" checksum="9F255796DB4C77AD" modified="2010-05-18" version="1">MKPFEYNAHPAHVLFGTGTIKQLSAEIERLGVNSPLLLYTLRQEKLVDDVRRQLQGKVAGAFDGAVMHVPTHVTEKALAYAKEHGADGIVSIGGGSVIGLGKAISLRTGLPHLCVPTTYSGSEMTPILGETHDGVKSTRTDPKILPAAVIYDVDLTMSMPASLSATSGMNAIAHAVEALYAHNGNPIVNLLAREGIRSLSTALPDIVANPQSKSARSDALYGAWLCGSCLGSVGMALHHKLCHALGGSFNLPHAETHTAVLPHAVAYNSPNTPEAMTTLAELLPGSQGDAIRGLNVLMQKLQVKRGAREFGMKEEDIDKAAEIAMRNVYCNPREVKKDAIRELLRRVWAGEEARADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5B3</accession>
    <name>D4D5B3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023536.1">
        <property type="nucleotide sequence ID" value="XM_003023490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5B3"/>
    <dbReference type="GeneID" id="9577008"/>
    <dbReference type="KEGG" id="tve:TRV_02283"/>
    <dbReference type="HOGENOM" id="CLU_2039764_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="121" mass="13969" checksum="F6838919119A7285" modified="2010-05-18" version="1">MTLNPIRRLVNCKEESPTVAKMWLVESYIRRYDWVVCPYFGFWALEILLGSPKTKQRLQTMAGRDLPCSSRVEHERKHIHTLSETTLVKLAADRELPLSGWDVEETQDPLVVSIECPKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5J9</accession>
    <name>D4D5J9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023477.1">
        <property type="nucleotide sequence ID" value="XM_003023431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5J9"/>
    <dbReference type="GeneID" id="9583497"/>
    <dbReference type="KEGG" id="tve:TRV_02371"/>
    <dbReference type="HOGENOM" id="CLU_062068_1_0_1"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="302" mass="33998" checksum="57AE7656DDA55D1B" modified="2010-05-18" version="1">MAESGCDYIQLRDVQLPVPVYLQTDAWRRTNKPQPATFSVRISYPAALISLAAENDTVGYTLNYGTLYRSIESAIISSNKDTIPDENAGDPSTRPSYSKDIVDVALTISDAAHKVLWSEIGATERDQDDTIFQDRWFTEKKEEITVDLHLPKAILRAERGLFCTLVTRRRPVKEEDNFMDFDLTVRIEGIRCACIIGVNPHEREDKQIVELALTFRRIKGKTRMIPKEYQTMVSKVAESVDKTSYETVEALATHAAKIVLVEFPLDEVTVRVEKPSAMAFVAFSGLEITRAASFFGVSRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5P3</accession>
    <name>D4D5P3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023432.1">
        <property type="nucleotide sequence ID" value="XM_003023386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5P3"/>
    <dbReference type="GeneID" id="9583452"/>
    <dbReference type="KEGG" id="tve:TRV_02416"/>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="30393" checksum="2E9EE4A75AF4D3D3" modified="2010-05-18" version="1">MSDTSSQRTLPSPPFYAVEGVNNLRDVGGYTVSPTTSVRRNFIYRSAHLSSVTPTGAKTIVDELGISYIYDFRSEVEIARYPLVDIPGTTFIHVPVFKDQDASPANLALRYKDYAADEGPAGFIRAYKDILVSGAKFAYKVVFEHIRDQPTQSLLFHCTAGKDRTGVFAALVLRLAGVLDNEVIGKEYELTEAGLDGLREEFIQKLLQHPSVGGDRDAAVRMTSAKAAAITGTLEWLDNEYGGVEGYMRKEIGFNDEDIRRIKKNIVVEGSGVCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5R9</accession>
    <name>D4D5R9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023340.1">
        <property type="nucleotide sequence ID" value="XM_003023294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5R9"/>
    <dbReference type="GeneID" id="9583359"/>
    <dbReference type="KEGG" id="tve:TRV_02442"/>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="222" mass="23762" checksum="97E7F07193B56AB1" modified="2010-05-18" version="1">MAQTLPKNVHVSRHPCLQVKLSQLRSGKASSRETNDLVHEIATIIGCEAFAENISVAPGEKNTTPLGYEYTTSFITPDKIALVPILRSGLGMVNVHHLGLFREPTTLEPVEYYNNLPFQPNSTGVNSAAAKLAIIIDPVVATGSTASAAIQTLREWGVERILFLCILGSHAGLIKAAGEWEEGVQVWTGAVDEQVDMKGMIQPGLGDIGDRLFSAGGRTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T6</accession>
    <name>D4D5T6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023357.1">
        <property type="nucleotide sequence ID" value="XM_003023311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T6"/>
    <dbReference type="GeneID" id="9583377"/>
    <dbReference type="KEGG" id="tve:TRV_02459"/>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="695" mass="74459" checksum="EC590BE8431093BE" modified="2010-05-18" version="1">MHPSAHDCEVSGSGGPVSESQAYYDEQPQADRPAKHESPSNPSPKHVAFELLLDESSKMRARIPMRVQIYPHDTTDSIVTTVKNFYGIYEGTASGVSFEDQDGNTLIARYENLKNSMTVYVRVIPNHHYPEQHSPPSYYAVSPMDNYSRPTLGEPFSMPPPQGSQAINYGQSVSRPTSRAAAAGKRSVSPPARGRRSASRQKSSRAGVKSRGSSTHGSFHDDAHMPCSDSDGGHSSVSGSRRPKSEHFGSADISMENILQDGRRKRPKFESSELPLFAPPQVPRTTSASSISPQRRSLAPDASPFARPSQNAFSGYQALASPQGFGNHEKLHSLQNGSGNNPYATPTVPHHGHRLRNRANSNSAVHYATPVNGHGILPTPDPTIASCISDEDVAMQLIRLGDTSNFSHGRNSTSTVDDAFSGIADAASSTGATTDISDVSGDETDLPTKIRERRASSDSLPGLPKKNKTLDEILPSCESSDPASDDIDGEYQNLASQDNIKSEYDDDPSYEAQSSRTKRARKSASTATTAATSAKATGAKQASTAKGGRNAKNRSAPASRKGKQAPTSSAKPVPPPLLPATAQQGGVNFQNQLAADEEDLSTKPRCQRCRKSKKGCDRQRPCQRCKDAGIGIEGCISEDENNGRKGRYGRHMGVSVKKDPSAIAAKAQEAQDTAAQTPASSTTAAVPDKNKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6B2</accession>
    <name>D4D6B2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000136">
        <property type="protein sequence ID" value="EFE42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023233.1">
        <property type="nucleotide sequence ID" value="XM_003023187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6B2"/>
    <dbReference type="GeneID" id="9583250"/>
    <dbReference type="KEGG" id="tve:TRV_02637"/>
    <dbReference type="HOGENOM" id="CLU_2225109_0_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="106" mass="11821" checksum="078CE804E66312BF" modified="2010-05-18" version="1">MAKPRTPLAATSFLLTPGNPQSVRVYYGTEDNRILEKGTEGGTYWYDGAFEHSAIPDSQVAAVDWGNGGVFNIRLYIQDGAFKNGISEWAWFRRSWRRGILAIPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E6</accession>
    <name>D4D6E6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023208.1">
        <property type="nucleotide sequence ID" value="XM_003023162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E6"/>
    <dbReference type="GeneID" id="9583228"/>
    <dbReference type="KEGG" id="tve:TRV_02671"/>
    <dbReference type="HOGENOM" id="CLU_180292_0_0_1"/>
    <dbReference type="OrthoDB" id="4173831at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055288" description="Invertebrate defensins family profile domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="4">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="75" mass="7759" checksum="B36471E30759C034" modified="2010-05-18" version="1">MQFTKLATVLIVSLMGSAAIAAPPVDNAPAAAADEVAAENLGKRGFGCPLNERECHAHCLSIGRKFGYCGGSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q3</accession>
    <name>D4D6Q3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023090.1">
        <property type="nucleotide sequence ID" value="XM_003023044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q3"/>
    <dbReference type="GeneID" id="9583110"/>
    <dbReference type="KEGG" id="tve:TRV_02780"/>
    <dbReference type="HOGENOM" id="CLU_094640_0_0_1"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="224" mass="24172" checksum="7D82CD8A0503B483" modified="2010-05-18" version="1">MSNEIHLRLPSRLSSPAAATAETTASAASFHASSPGISSTIPLIGTWYALSSSVEFLRDKKNVSIKYSLKEPGHAKEAGGNVVEFANDTVLDSVTSYQLLSGEGSDIVDTTVGTERPTPNSLPGVFTWRGTGFAKFITNRWEILGYGNLPLESSKPIQEGDEQPMWMVIYADKSMFSPPGLSIHSKGTKSLPAQTMDQIRAALGNLQPKELKDSVRGMVDILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D757</accession>
    <name>D4D757_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022949.1">
        <property type="nucleotide sequence ID" value="XM_003022903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576975"/>
    <dbReference type="KEGG" id="tve:TRV_02936"/>
    <dbReference type="HOGENOM" id="CLU_002983_1_0_1"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1328" mass="141822" checksum="3CBAE72D3D2CD98B" modified="2010-05-18" version="1">MPGDVSPAFMGGRVRSTSLSFERSASISSRASAPSPPLVNPAPQYVAISAATQLISASHGVNPLQPKEGRPGNAIVTPPSLVLVNGFLDHILFNILLAAKSTKLAAIRPAVSDVLKPRLARAVVSVADEELSEYMGTSDEEELTGYGYSQEAAGQGHFELERSWKLTRLRCMVYARLGDMEEDDEEEYLQREGLSETNGRPYFMNHGGMLSPAAAIFLTSILEYIAENILIIAGENSSARLGFSDENDERKYQGGTLVVDDVDVEKVALNPTLGRLWRTWRKNLRAPALSRTLSRESLVRRGCSSRTSTHSSVGTFDTFDTFNGFSFGRKISSADQHVSDTASVSTCVNINPADIPLPISEYGIDEIEIPGFSAQLAVALPARSLRPRSLFISSPEVAGRPVLARSISAISPRVVMASASASSSLQPARSSTRRAHIRSQSLPQSMYITSPLAPSPTRVKRSASSAAETRKEDEHLESMPEAEEPETDTKAGESASASAAAAAAAAAATVAATAAATAAPASAASELEQAGPDSASIYSPYHPASISSPRCQDSSMEQETVSPPSSETGDNNSVVSSIYTIPEASRVSSKESAESTTSQTADSSSARITTCEDIADGNPAYYSSSSLTDDDQAARKAARRKATAPLPPTSNPFGDNIVETSFVSRSPRSPSRGARLTPLTEVADNTPVQNERSSPDQASINSGDSEPSVTPRSRAWLTKINTNCSTRQNLPVSPGSERAAVQRVTPPPSSISRDSSKLRRSESAGSRRDGRPITSGSGVSQGSNRIRGLISRQPSDLSVSVICSSDGSGSGSTALEELLMSDETIHYTLTPRNMREMEEVGSPRWAATRPADLAADPADTSSVKSGKQSRRILSPTFRSPSISSPVPQSPLARNPPSPPPPKPKMPAPQARDARVENASVRDFANFIRSTGPDKGLHPPAAQFNSIARAGNNSIPNSPATTGTYSTSPLATPKASTKDNNNNNTSSNITSTPRATNPNRPRLEARPAVFVRDNKTSELIDFIRQGPPDPQARRLQQKTVAPFRNTMNSDDFSSFSQTIRSERDFTIGDSSIPGTQDGSMVAASVASVNSHTALIDSSTRPNSRTLQYRLSPTPNIRGDGSATPAKTRRRVRDPYAIDSDSEDEYDDVRDVAKPKEESLAEFLKNGPPPPPPPKPQPFTINIQKANELHRQKAMRPPISRSVTLDSTSEAGSPAPPRLVDLPPKYNYHSHAGRPQASLTSGSSFVATIHADQPDNQWHSGGRLPKGVIKGVDADSLYRSNKSDTAALADFLKNTGPPSSPSVSSLQSMKTGTSASWTFKTFLRKKKQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7G2</accession>
    <name>D4D7G2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022820.1">
        <property type="nucleotide sequence ID" value="XM_003022774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7G2"/>
    <dbReference type="GeneID" id="9581544"/>
    <dbReference type="KEGG" id="tve:TRV_03044"/>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="471" mass="50490" checksum="8E08BEEC9D875CE9" modified="2010-05-18" version="1">MGDEMQTKPGTGNESAAAAGADQKDQLAQLVKLATANEAAKDYGKAVDLYSQAAELQAEINGDMAPENADILYSYGKCLYHVGVSKSDVLGAKIPQTATEPAGGSSSKSGKGPGSGEGEEASSSIIKDAIARHAENGEGAGPSSSLGKAGATPLFQFIGDENLEASDDDEEEDEEGEGGEEGKGGGDEEEDDDFANAFEILDLSRVLYERQRSELEQDKEKNEEKLRRVKERLADTYDLQAEISLEGERFPDAAADLQSSLRIKEELYSGEDPIIAECYYKLSLALEFSSVMKKDGEDGEKGKGKASENSNAEPEYDAAAREQAAVYMEKAIKSCKGRIAKEEARIESIGSNDGETVARIKRNIDDVKDIVSDMEQRLVDLRRPPVAIPNAERTKEEQAAAQAIKLDELTKVANDLTGLVKKKKQPVAATAVVSSTSSAGEQQQPEAKGKRPLESAEEEALNPKKVKGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Q3</accession>
    <name>D4D7Q3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022755.1">
        <property type="nucleotide sequence ID" value="XM_003022709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Q3"/>
    <dbReference type="GeneID" id="9581445"/>
    <dbReference type="KEGG" id="tve:TRV_03137"/>
    <dbReference type="HOGENOM" id="CLU_024063_1_1_1"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45129" checksum="D31284668D0E77C2" modified="2010-05-18" version="1">MATRTSTRHAAAKANEALHENAQQGRRKSTEAGQKRKASSKKDIPEPKREKHTKDEIKTSADEGVIKQEPTKDTTMQNEPTKSEAERPQAHHAYVKDEEAEESSEMKPSDIYGNKKSKAAKDTKPESPRGESIPSNIMEEGIIYFFFRGKVGVEEPKGVDEVARTFIVLRPQPIGANLSAGLAGDENNCRLLLLPKKTVPTSSHEKYMGFVEKAGVDLKTLKESFLGEEYETKTKGTRFSPTATPLAEGVYALTSTTRTSHLAYILTIPTELSQVQKDFGLREKGSFIVASKNPKYPGPSSARLPKPPDYPQSVIDDFRDLRWVPLKPKFIDYPNAQFMMLGEAQGHLGKGGKTEEKAPGQEDAGEELEHLEGEDEIRAEALNDSDKVFEDLGLSAKQFPQVPTTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7V8</accession>
    <name>D4D7V8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022671.1">
        <property type="nucleotide sequence ID" value="XM_003022625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7V8"/>
    <dbReference type="GeneID" id="9581330"/>
    <dbReference type="KEGG" id="tve:TRV_03192"/>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="442" mass="49071" checksum="CE8D4AF1CC9B408B" modified="2010-05-18" version="1">MTKSSKRPTSLFHFWPDRARHWSHPNIKHRHLVFASSVSTHRDYAWLFDLFARFLVTLLLVTDIYPPLLLQLHSWIADWDPFSTSTVQRPAARLARPIAAFPTGVPGLDAMGFGDFDAICRKAALPLCSLVGPKTGFAGTRGILPNCYARSIEVANTIIFQGAAGIIHIMALGMAVVMIIHIRSKFTAVGRKEIITSFYLYMALTVCSLVLDTGVTPPGSAAMPYFAAVQNGLTSAMCTSLLINGFVGFQLYEDGTALSVWLLRFSSLGMGLVSGAISLLTFQGWAGLSPTNTVAMFVVLYVLNALCLAIYVIMQIILVVNTLQDRWPLGHITFGVFFFVAGQVILYVFSDTVCEGVQHYLDGLFFVTFCNLLSVMMIYKYWDSITKEDLEFSVGLKQNNWEVKELLPEEERRATFYVDTNSEYAGSMYHNRSSAHGGHSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D874</accession>
    <name>D4D874_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000170">
        <property type="protein sequence ID" value="EFE41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022571.1">
        <property type="nucleotide sequence ID" value="XM_003022525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D874"/>
    <dbReference type="GeneID" id="9581229"/>
    <dbReference type="KEGG" id="tve:TRV_03310"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="185"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="549" mass="61805" checksum="3D25121B23AF5721" modified="2010-05-18" version="1">MRLLWASSVGKHSTVLYRRCLSTTPTPFNDHQANPITLRCAQIFEQSKSGTRPSSLDHKELRVQGHVRFLRKQKRFAFAHISDGSSLQPIQAVLTPEQATNLTQGAAVEVTGIWQPSPPGKQQSHELQATKVDIVGEADPAASSSTQTYPIQKKFHTPDFLRQLPHLRLRTPFNALLSRLRSEFIYQVTEEFRSHRHLNFVQVQPPLITSSDCEGAGEVFSIRPRDVVIEEGKAVEFFKSPKYLTVSSQLHLEAYAAELGNVWTLSPTFRAEKSDTPRHLSEFYMLEAEMSYMDSLEPLTAFVETLLRNMTQRVYKSPVAQELFSFKATDDLTKDTSNADLEKRWMALMEGPRWPRITFAHAIKHLHEAVNTGRVTFEFSPSWSGGLQLEHEKFLVDTIGKGLPIFVTDYPKAVKPFYMLPSSGSSDESGETVACFDLLLPEICEVVGGSLREHRLSPLIQNMREHGLLKLKDSTPEPSSTVDAKAPYPHLLANEELGSIQWYADLRRWGTVPHGGFGLGFDRFVGYLAGVSSLRDLVPFPRHFGRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8F4</accession>
    <name>D4D8F4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000176">
        <property type="protein sequence ID" value="EFE41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022494.1">
        <property type="nucleotide sequence ID" value="XM_003022448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8F4"/>
    <dbReference type="GeneID" id="9581071"/>
    <dbReference type="KEGG" id="tve:TRV_03390"/>
    <dbReference type="HOGENOM" id="CLU_024263_0_1_1"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="36460" checksum="6C30617C2BB6E69C" modified="2010-05-18" version="1">MSSSPDMAHGPPGKMVLTLLKQPGIEAHGPPYPPPGAGLGGRPTLSVDVAISAVFIAIFLVGAVSHFTLFRKNLKRNYKFIPSAATGGFCIARIVANTLRIVWAAKPMNIDVAIAAQVFVAAGVLILFVINLIFAQRMLRASHPVVGWSRPVSYAFKILYILIGLTLVTVITATVQSFFTLVPNTRRIDRDLQLFGGSLLTFVAFLPILILAFIHLAPQRQPRDQFGSGSWSAKVIIVTAAALLLTLGAGFRIGVSASPIRAATNPAWYHHKACFYIFNFVLEAMVVYIFLFGRVDRRFFVPNGSSKVRNYSDNRIEPKTSDNDEEGQSQVVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8H3</accession>
    <name>D4D8H3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_03409</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022459.1">
        <property type="nucleotide sequence ID" value="XM_003022413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8H3"/>
    <dbReference type="GeneID" id="9581006"/>
    <dbReference type="KEGG" id="tve:TRV_03409"/>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="15">
        <location>
            <begin position="546"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="765" mass="86196" checksum="2BA487BABFDE15BA" modified="2010-05-18" version="1">MNSTIESEILIQPQKADRQEEKKIIGTAGLLFVARLEGSFGKVEVIEALFFSDVLSFCSFFYLFGLPLLGFTQRQFRRLQQLQPHNSNNYGINYDIRQQQIYAIEIKDRGAMDVKGLTLRSKASRRRPKISAPQPITNHNNSAAPAAGRAPEARHHPQPSDATSDLVKRRYSAKFNTLPGIDSEAPPVPSLPSAPIDHFASDREPTSAGGAQPIRVDANALRNPNLPIESYVTGLLEHASEQDIRDYQSDLRKLKSKTSSDLQQSVYQNRTQFIKISKEAEKLREEMSTLRGLMSELTTTLGQANATNGANGSQPDFDDAPARRHAHRSSIANLESMWNIQLQQLWKNVERSQKYLPAIPGRHIVMESSQWVELDSATWKPRRPVHIVLLNDHLLIAAKKRKRVDPNTANGKSVSVPTKLVAEECWPLQDIDMIDLGSGLNSGEDMDERGVPNAVNIRYGQSSFTYRHDQRNNKAKNELVMTFRKTLEELRKSLKSEAEVAAKSREALMNNSQPASHRHSEFLDTMDPRDKLEVLIDVDGKQQNMRWVEGQLDELDIDIAIQVFETAVSRVEKLRKLAKGLKGNQTAQEAINSGVDARANKLAEILLRALVDTNSFMNATKTNVAWLTRLGYDDRAREAYLNARSQIITKRARHCVFEGDLLLYIFQISFVYFTMIRNTIAIYQQCFPSPMSSASIKWGKDHLDDFNATLSRQLSSVEPSNPVWEKCMEIVYQHASSLSEVGVDFKDMIRVEGLVVKSPNSTPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8R0</accession>
    <name>D4D8R0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000181">
        <property type="protein sequence ID" value="EFE41753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022371.1">
        <property type="nucleotide sequence ID" value="XM_003022325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8R0"/>
    <dbReference type="GeneID" id="9580928"/>
    <dbReference type="KEGG" id="tve:TRV_03497"/>
    <dbReference type="HOGENOM" id="CLU_021479_0_0_1"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="225"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="779" mass="84965" checksum="971CE4C305F4A1FE" modified="2010-05-18" version="1">MAPSPPRLRILSVGGNAVSAFLSWRLQATHSCDVTLVWKSSFESVQQYGISFKYGYSLSTLRSRLGGYLGWLTLIVKIRSKVFGNERFKPRHVVRTPEEGASISSSYDYVILCVKALPDIYDLAGVIESVVTPQHTCILVNTTSTIGIEAHLEQRFPKNVVLSLVSAVDIVQTGASEFEHTSSTDLWVGPASKNAMIPTAIQNDMAAALAITLGTAQVNCKVSENILQQQYDRMIGPIAFYPISVLFETPNHSQLLEKVGVRQMVSDVLDELIALAKSQGCTFADDFKEKTIQAMTAPTENPSIMYQDFQARRPMEIETYLGAPVKMATENGVKIPRIETLYAMLHHINITNQNRQPPTEPSSPVVTLPPRVSSAPSRPPMNGAPRGGGNFRGQPPPPRRGPSSMANNPRPLPPQANGHGPRAPKQGMPRDLSYEDPSLDEFSHLVLYEDGQDDAQSQHGGYNGHTNGGPSPSELALKERELMLRQREIALREQEIQMRRRGAGVARAPSVRGGFDDDDEDGYDLDHRSPAIPQIDPDNFDMMSVTSRRNRKTPTTPAKEFRKNPEMNSSRPPSVFSRHFGAGRHRASARIMEEIPGVHDSLLDNPMMSYSSNRYGNVDRREMHNESRANSLTASRMGEMGHGTFPPSRRTSQSPGNPSLPNGRMGRPGTGPEGGQMPLPNGMGHSGRPSPPGMMKAPVPRHPPGQGNAIMPHQVEQHVGVSNHPYPPKGPSNVRSLTGSASASAESGDSGASAHIDSENSAYSSQSSLDPVHRGHAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Z6</accession>
    <name>D4D8Z6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TRV_03584</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022262.1">
        <property type="nucleotide sequence ID" value="XM_003022216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Z6"/>
    <dbReference type="GeneID" id="9576862"/>
    <dbReference type="KEGG" id="tve:TRV_03584"/>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="187"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EFE41644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="461" mass="50116" checksum="DF611D6DFECD2DB7" modified="2010-05-18" version="1">MATPHPTQRAFIALGSNLGDRVAMIEEACREMEARGIKIRRTSSLFETAPMYVVDQGTFLNGACEVETSKSPMELLDTLQSIEIDMGRRKVIDKGPRNIDLDILLYGHETVSNDRLIVPHKLMLEREFVLRPLCQLIPNKYPLVEGEGKTYTSHLQALPPSNPPPIAMIPMPAGLPPITPTKPSRNTLLMAVLNVTPDSFSDGGIHSSTDPTALLETVKAYIDAGVSIIDVGGESTRPNAEPVTEAEELSRVIPVIELIRSLPEASKIAISIDTYRANVAEAAVNAGADIINDISAGLLDPEMLPTMARLQKTVMLSHTRGTPKTMNKLTHYPDGVLAGIQSELAERVNAAEQAGVRRWRIIADPGVGFAKTQDQNLTILRNLDQLRQAEELKYMPWLVGVSRKGFVGRITGVKKAGERTWGTAAAVTAAISGGADIVRVHDVSEMAQVTRMADAIFRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9D4</accession>
    <name>D4D9D4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000190">
        <property type="protein sequence ID" value="EFE41547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022165.1">
        <property type="nucleotide sequence ID" value="XM_003022119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9D4"/>
    <dbReference type="GeneID" id="9579046"/>
    <dbReference type="KEGG" id="tve:TRV_03725"/>
    <dbReference type="HOGENOM" id="CLU_041557_0_0_1"/>
    <dbReference type="OrthoDB" id="4173234at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="360" mass="40388" checksum="A731A35F627EA2AF" modified="2010-05-18" version="1">MFDFHIDESNIKVDMLSFYNDSIPFLESSAALVTEKPIMQDVTSQNIPVSPYTKETSEVSRGQCSTTEMAPDNYVRESMVFGLAQYDQLCCLQRMRSCTGNDKRGVFSRLRNYPIHGMLEHVRRLTELIRQLMPISDSGDSSPRILCSELVSETIPDIDSCLLNEEALMNDFSDMLAHPFSESCLSSGDSISRLSPLTPSKQTPVDTSTILLFVSCYLRLARAFALFFTDLHAFLLFPSAIDPTPSGELRIFPGLKLGSFQSYVGVSLEISIAIQVSERMLCRLHDSLGLSWNQCSSESLPNSQLSVDAWSNADTITRAMIKTIQAQERIDAQDERGDTFTRLLQIMENVKKLVKTQPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9K4</accession>
    <name>D4D9K4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sin3 complex subunit (Stb2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022056.1">
        <property type="nucleotide sequence ID" value="XM_003022010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9K4"/>
    <dbReference type="GeneID" id="9578940"/>
    <dbReference type="KEGG" id="tve:TRV_03797"/>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="876" mass="98040" checksum="6A92918170A72705" modified="2010-05-18" version="1">MDPAGTTSIALVDERLEQYAARQAAEAQQSEPGTPTQQLTSSKSAQRVSSKASFQRLVLTDPVAFKYLEEDPCAVTISKRLSISGYQVYIVEQWVCSRAHPTFFINTYTGDKSHTVIAGVLSVPTDEKKWSERMRVYFNAMDQFHTRKQESSFGTVMVTNLSTFPSMLTTIPVQDGDVGLHLDDFIVNENLKRLGCSGRAGLTVKPPAADTQAKFHQLYQTCDKIELNTSVKELIRFCQLALVMFLKLAPEYADGLLCNHTERAIHEWWAETGSFLYGIEPLDGILGPTTVAAILGTFMGARNRLHAYGAPVSKDPFDIHGFEKGIYSFQKAQSLERTRRLDSVTLEKLHRVTAKAASGEVGGLQRAVKSTVAELSGKGGEMVMEMVGGGKDKAGISEIETYEIERFIQLITGDHARWLWRGKPKPPYEARYDIGDERIFTPDRGGGYIWTRRKKDDYPSNRPSIEGDQRKQTDSLTAVDDKDQLRVTLKRSVTNKVSDARAGLGRFRDAVGLPTLRPHHHKHSKESVDLDANLSPQLFMGETPTSTSSKDGGGPEGSAQMDSVALSEACRLEPMVDQKGYSPLTPPELGRARTYESLLGKEISPPDKALDLREAEGVLGGSEVTERKQDGEYHGLIPVTRIRRRAQSVGLPELDRLVSKDKAYPRRLSSSYAEEYLLRWEEIGDIYSEAIDPTVGLADAILYEDIIFSDNQDITKRIREVGSTEVNWVDEKVTVAEKIEKAVKARALETQAEYQRKLVELREMYGASRGAMAEEEDAYMQVAKNVEMMSEKLDYDVDTLRSRIEDAEAVLRDYEHVISNLEKRTASVLDGQEAEKISWMQWVHELWNRQRNGFQTQALKDYNKDNSANFTGGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9V3</accession>
    <name>D4D9V3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_03896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000199">
        <property type="protein sequence ID" value="EFE41384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022002.1">
        <property type="nucleotide sequence ID" value="XM_003021956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9V3"/>
    <dbReference type="GeneID" id="9578886"/>
    <dbReference type="KEGG" id="tve:TRV_03896"/>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_1"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="83"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="266"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="474"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="771"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE41384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="975" mass="108692" checksum="EED9EA04C43798AF" modified="2010-05-18" version="1">MWVPCAIRGHVRFGGPPTVSHHLLWRFRSLPVRTASTYANANQPSKKLDLLAIDKRWKELWEGREASVRLMSSSKEKAYVLPMFPYPSGTLHMGHVRVYTISDVLARFKQMKGYDVLHPMGWDAFGLPAENAAIERGIHPEGWTKQNIANMRNQLKDLGIRFDWDTEVMTCSPEFYKHTQKLFLMLHEKGLAYQAEAVVNYDPVDKTVLANEQVDSNGCSWRSGAKVEKRELKQWFFRITAFKEALLKDLDSLSGSWPDRILTMQRHWLGKSRGALVPFTLSIPGETLDIEVFTTRPDTLHGVQYIALSTSHPVVKKMAANTPELQEFINSTGSLPPETKAGFKLPGVKAINPIYHLERNPHLPSSLPVYVAPYVLPDYGEGAVMGVPGHDSRDFGFWKENSPSEPIVSVVMPLKTGPDSNDKHGADSAFSGHGQTTDICGSYSKMPSKTAGEKIINDLKDKGSRARFAENWRLRDWLISRQRYWGAPIPIIHCDSCGAVPVPASQLPVELPAIPGSQLKDKTGNPLESADEWLHTECPSCKGPATRDTDTMDTFVDSSWYFLRFLDPKNNDLPVSPSKSRPVDIYIGGIEHAILHLLYSRFIFKFLAAEGKIENAAEPPEPFLKLLSQGMVHGKTYSDPKTGRFLRPGEVDLSVKGPPVLTGTQIPANISFEKMSKSKYNGVDPNTCIESYGADATRAHVLFSAPVSEVLEWDETKIVGIQRWFSRIWKAVEDTGNSLKRANFSSAPDALSSLNDMALPPLDKLSETESNLLHMTNNTISSVSYCLEKNQYGLNTVISDLIKLTNAISAVPLPEESSKTSPSAQSVTPLHTTLYIALNSLLRMLAPIAPAFASECWEVLHKPLFERVDTVPWVLSSPWPSEFLSESDIKQIRSRGAKTVAVQVNGKLRFTASVPPFSGNSATPESISKEQEQEWILSHVLQTKEGKVWLQEKNNWDKRKRVVVVGSGKVINVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y7</accession>
    <name>D4D9Y7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_03930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021944.1">
        <property type="nucleotide sequence ID" value="XM_003021898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y7"/>
    <dbReference type="GeneID" id="9578827"/>
    <dbReference type="KEGG" id="tve:TRV_03930"/>
    <dbReference type="HOGENOM" id="CLU_026386_1_0_1"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE41326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="509" mass="56908" checksum="27EF5744397DB7F5" modified="2010-05-18" version="1">MRNKATSYLRKPIANPRSFLPGRRQKIRQSWSKYNLFNITQVRLPFTKSRTFFQQKWSAKSLARGYHGEQVRESQWERMFSRRLRAVVPMDPFDLARNDGSKNAAGRGSGMDKGGKEDGRQVQDTPYMLMTFAPLERRLDVAIFRAMFASSTRQARQFVIHGGVTVNGKKMQYPGYLLNPGDMFQVDPERVMYATGAPKDKSLRRAGRLRRRMGAKSKEEKEGEGEETKAEETKAEDKEQKKEEGKEDEDPRQMLKELLSGAKGIMTSSGDLLPAKRRQAIRAFQRSVKQVLSRSSTTTTMTDNLEAQFLALKNMIDEDTKRAAEAAKKAAAKKAEQAAPSTESPSSATEPSSSASPTTPSPSTTPNADTTSTTTTTTTTTNNNNNNNDINNQTSRDSKASSGIDDLAASLSDVELADYSPADLKALKLALEEIHENPIDSTKPYATPWRPRDYMSPFAFVPRYLEVNHNICAAVYLRHPVARPGRAEVPTPFNETIGGAAFAWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA10</accession>
    <name>D4DA10_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021924.1">
        <property type="nucleotide sequence ID" value="XM_003021878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA10"/>
    <dbReference type="GeneID" id="9578807"/>
    <dbReference type="KEGG" id="tve:TRV_03954"/>
    <dbReference type="HOGENOM" id="CLU_012440_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="86088" checksum="DD5998CC97955BE2" modified="2010-05-18" version="1">MLTGPSEASKTRMRKVSAEEIFDLQSLRKVYNNPDRTNEAVLRVFHVQNADWAKEYLLRKFNIDNRDDLVGNDFGKYVRHKNPERRGGRPFLNGKTWKVQYDPWRGISKTSFGLDYLKQYHKSAHLTPRHRRSPEDDTLKMMELDSWGDQDNPSRGYDVYVQRFSCYIQHKQATGLPSLEMEDSDIKNPYHIEDCQTGDSPEKRKDVYVPCLSSLDNGNAILIFDNSHTGCLEDTLIPPRQTWEERWRRLPFFLAFESKDLVESDEQLAYHSTRIILDDIFKVLTANWDSFLNLAMDHVSILEDKIYERPADETRAPLLWTNSSLWLKVEKLLFIHLDIVKEMITRLQDLTDDVESDTPWLESIPGDFERLGTTITEDLIKPTENLISLLYQSVSIRDSRHSIQLNVSMWRLSWITFIFLPMTFITGFFGMNVDTFKDDPDIKWYFIATVPFMFLVLLLWYIIKHYLASRRQTPHQRGIYENFFNEMADRNPSLWSRMGPRDYVVPQGILSRIKWHFIKVWSAPERTILLDADSDGSGGDMGTIFKIKQYLIRRWTSQLRNNKAVKETALEDGLIVPEDDTVSEAHSIADGLAGATEMLVIPATPAVESRIVPEIVTLHTSTQTQPDAPEAIAPRSALSLMSSAHRRSSSAGRTSGLLVEEEDYQWLSERGRQGMRWAWRSSSSRGRSPHESPRRHSRSRSREDREVEKSGGSTSPVDQGTETMPQSNDDNNESPTTVHDTSNTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAG0</accession>
    <name>D4DAG0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021776.1">
        <property type="nucleotide sequence ID" value="XM_003021730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAG0"/>
    <dbReference type="GeneID" id="9578656"/>
    <dbReference type="KEGG" id="tve:TRV_04107"/>
    <dbReference type="HOGENOM" id="CLU_518943_0_0_1"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="57231" checksum="781C482D33EE08E0" modified="2010-05-18" version="1">MDPLEFTPWHQLAPRGITGDVKDTFSSWDKCMAKSYCKWPAIVGIIVGGLILLSVVWCLVGCICCGYTCCKGCCECCSCCCPSSSSSRKPPPAPAYDSRSKFADDYSGYQRPAPPVYNTQAASSTPSYAQFDTLGSRPAPTVPTSTARVNDDALPNMPTWQDATTRRVEDTSHHNEEMEMSHLNPVTGHSVVDDPGAAHGSAYYQHAQPVSPIYPPDHHHTRHSQSMNMNMNMGGGYRGLDQGHISPSIPPTAIGIAHSPGCGPAPLSNMYHDSQQDQQTSGQIYAPPRYNTQSPSTIGIATPAPPGAGDAYGYTHPNGSSRSFTRSPVQHIRGTPSPRPQLSPILLSRSATKDIHALFTLDVNTTSSLERTGVGCRPATGGRAVGITATSSSKLVDGRKEARRELLERCIVYLLFYFFLFPPFYYLLPFGFFPSLRSCCDGSYYSFVDMFGYIPARIPVVVYILLLTFLFLLYRYVDELSTVYFSCFLPPFTWVTNLTGALGGLTFAGLIGCLDAYLLTSRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAT8</accession>
    <name>D4DAT8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021656.1">
        <property type="nucleotide sequence ID" value="XM_003021610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578617"/>
    <dbReference type="KEGG" id="tve:TRV_04236"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="58"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2420"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="942"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="974"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2507" mass="274056" checksum="E972463D0DD5BF60" modified="2010-05-18" version="1">MTINNNCNVDAQDVTMGLKMNGTSTNGHSTNGVDAKGPLPDTNGINGVSADAIPCNGQIPIAICGMACRLPGGLTTPEEFWNFLLAKKDGRCRVPESRYNINSYYSDVKQPGTVSTEYGYFLDENTDIAALDMSFFTMTRTEVERADPQQRLMLEVAREAFEDAGVTNWRGKTIGTYIGNFGEDWLEMLGKETQPWGIHRISGSGDFVVANRLSYEFDLQGPSMTIRTACSSALVALNEACAAISRGDCESALVGGVNLILAPGMSMAMQEQGVLSKDGSCKTFSADANGYARGEAVTAVFIKPLADALRDGNPIRAVVRATSHNADGKTPTLSQPSTDAQEALIRRAYELGGINNYAETAMVECHGTGTPTGDPIEAKAVARVFGEKGVHIGSVKPNLGHTEAASGLVSLLKMVKALEHRIIPPNIKFTSPNPNIPFVDCKLTVPTEPTPWPEDRLERVSVNSFGIGGANAHVILESAAAHNIPTPVYETPETPQLLLFTANSPKSITQLIDNYKSWIEENPDKVGDLAYTLARRREHLPHRAFAIVSNGVVDSVSQPTRSKSANPPSVVMVFTGQGAQWPQMGRELLRSNEVFKSSIRALDQYLQTIDAEKPQYTIEEELKRPGKKSRLSLAEFSQPLCTAIQIALVDTLKSVGVVPDAVVGHSSGEIAAAYASGALTAKEAITAAHHRGAVTGRQKRPGTMAAIGLSWGETEKYLVPNVTIACDNSPKSVTISGDVDAVKSVIATIKEEQPQTLGRLLQVDKAYHSYHMKEIGEYYQFLIGEEMISRAPSALFFSSVTGHLLDTEQTIGSKYWQDNLESPVRFREAVMAILKHDIGKNSVFLEVGPHGALAGPLRQIFTQASSSAPYISTMTRNQDCTASFLAAIGALHSLNVGIDLKSLFPTGSCLPDLPRYPWNHEGSYWYETRLSKEWRNRKHPYHNLLGARVAESSDSEPVWRNLFHVTNTPWIRDHRVAENIVFPFCGYIALAGEAIRQLTDIEEGFSVRNILVSTALVLNEGKPTEIMASFRPHRLTNSLNSAWWEFTVTAYNGRNWTKHCTGEVSALSTALGQAQNPDTLPRKLNVRKWYEKMSKGGLDLGGSFQTLDTITTSTSTSTSHQQAVGNIVNGRQGDEANYHIHPTVLDGTLQILGAAAVNGYARKTKTWLPTSIDKISVNRCMSDVVTSVSAKLSSNFSVIGDGRCTSGGMTVVDAIGIRMSLADGAGASELPDAHAASRCKWRPDIDFLDMNELIHAPAGRTDHLRLLEELGDICLLLSQQSFSESPRSPMLPHLSKYVAWVQAQSTSIVTRLPWTWTGLDNEAISARIEGIISRLADTAAAPVASIIRQICTNMDSFLSGESFGSGFSDGMLLPVYEFIGQLDRTEFIRHLGHSKPNLRILEIGAGKGVSLHHSIVDELTRPDGEILCSKYTITSPGYVVKTTLEKLFPNMEFASFDISKDPFDQGFEDVGYDLIIAVNALHEAEDVIGSLANIKKLLRPDGRLFLQELCPSSKWVNYVLGLLPTWWSNVANEPAGTLRLGKEGWISKLSAAEFGNIEAVTLDADKPHQLTVTMAVRRSCSTPAKKITALLGDEGPAVTQILDQLDKEGYQVAKCKLGDIPPAGQDVISLLDVENPFFHDIKEAHFLLFKTFLLGLQDRDAGMLWVTHLIDIGCKDPRYAQILGLSRTIRTEQLADLATCQVDSFESNNSINQLLQVLAKFQARNGDEELNPDFEWAIFNERVQVARFHPFVLADELLVAEGANEMATLNVRTPGRVNSLHYARHERKALESDEVEIQVYSAGLNFRDVLVALGIVELPVRLFGIEAAGIVTRVGTDVSPNDLQIGDRVVCFCRKDAFSTYTTTLAAVCVRIPDSLSFNQAGTMLIPYFTAIHSMINVGRVSKGQSVLIHSACGGVGLAAIQVAQMLEAEVYATVGSEKKVEYLMENYHIPRNRIFNSRDKTFVDGVMRETEGRGVDFILNSLSGELLHATWSCVAEFGTMLEIGKRDLIGDGKLDMKPFLANRSYCCVDIDGLWKRIHIARALIFSILEFYNKGHISPLPTTIFPASQTQDAFRFMEKGQHIGRVGVSMKQSEEVELEFETTKRALKIAFDEESSYLMVGGLGGIGRAVSTWMVDHGVRELIYLSRSAGRTSKDDDFVRELQSMGCAVKLVSGDTTKLEDVHRAIAAATYPMKGIVQMSMVVANENFTEMSFDEWNASTAPKVQGTWNLHNASLAAGIDLDFFVMFSSVSGIVGQAGQANYASGNSFLDAFAQYRNGLGLAASVVDMGAVEDVGWISEHKGMMGKMSRSGFKPVLEQEVIDAMAICMLVHNKPGHAAEEVLATASKNASCFVHKNTFLVGLALLIPLHDPSNYVIWKRDRRMASYHNNSTISTATASTDILKSYLSSAQADPSILKSSEAAKLFAVEIGKKLFDLLLKPQDEINTSSPLLDLGLDSLVALELRAWIKQIFSFDLPILEMMSIGSLEILGQYAANEVYRTATENNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAU0</accession>
    <name>D4DAU0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021658.1">
        <property type="nucleotide sequence ID" value="XM_003021612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAU0"/>
    <dbReference type="GeneID" id="9578619"/>
    <dbReference type="KEGG" id="tve:TRV_04238"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="543" mass="60513" checksum="2FB926FD5B52DDE6" modified="2010-05-18" version="1">MGHIDDIFSIIYLGVAAGVYFKPEYAMCGSRVAAIAILSIIIILSKLVYQLFLYPRFFTPLKCFPTPSNRHWLTGNTKSLLVDTPHAEMKVWARDIPNEGIIRYYIAGNLERITVTSPKVLSEILVSKAYDFAKPLVIQQGLGRLLGNGILLAEGDEHKFQRKNLMPAFAYRHIKNLYPVFWSKSIEMVRLIRKELKGRKPTEDNTIEVRNWAGRSSLDIIGLAGIGRDFDSLRDPENSLSRSYEMVFTAPDVTTKALFMLGMLLGDTKWLAKLPTRRNKTIDTGRSNIRNAARQMIEEHKAKMKDPDVEIGVDIISVAMQSGNFDDENLVDQLMTFLGAGHETTAAALQWAIYSLCKHPEVQTRLREEVRANLPPINVGNPGPIDATAVDNLQYLNAVCNEVIRFCPSIPNTVRVALKDTTLMGNPIPKNTQIVISPELINHMPEFWGPDAGQFNPDRFMGPGNANKGGATSNYAFLSFLHGPRSCIGQGFAKSELACLLAAVVGSFEFELKYPDAKLEVREQATISPRDGVLAKFTPLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAU9</accession>
    <name>D4DAU9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021667.1">
        <property type="nucleotide sequence ID" value="XM_003021621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAU9"/>
    <dbReference type="GeneID" id="9576750"/>
    <dbReference type="KEGG" id="tve:TRV_04247"/>
    <dbReference type="HOGENOM" id="CLU_1876951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="136" mass="15132" checksum="4B049003A77DACEC" modified="2010-05-18" version="1">MTSIASLLNPEPDSTKKNQTVLAPGSSPGNERGSQSSPPAKKQKVSKDAAVFTRGRVRGPLKYPPCEWQDEKLAEAHKLFEIHPMGHITEFPRHIPYNSEKKSFLEKTGRESFEGNVSSIFVLYPSLKLTEHSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB83</accession>
    <name>D4DB83_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021535.1">
        <property type="nucleotide sequence ID" value="XM_003021489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB83"/>
    <dbReference type="ESTHER" id="trivh-d4db83">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="9578496"/>
    <dbReference type="KEGG" id="tve:TRV_04382"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="52103" checksum="BEDF78BD24779525" modified="2010-05-18" version="1">MLADPADRCIAGSLDGNDWGEDCLTANIFRPMETKAGQKLPVVVYFHGGAFNLGAAALLAWSEKPFIALNFNYRLGAFGFLSGELMAASNMLNTGLYDQLMLLEWVQRNIEQFGGDPNQVTIMGLSAGAHSIGHQIMYTKNGGRPLFHRALLESGATTARAVYPPKAPLPSVQFDEFALASGCSNVDRGQMISCLRKQSVRTVGQASIDVFNRYNPSDRWAFQPVIDGKIIRAAPISAWESGTWNKIPILTGFNTDEGSPFTPTRLDTSEDFTKFFKELIPALSESDLKELNNLYPDPAVHRESPYYDTRPIDVGSQYKRGTAAYGQYAYICPIQQTAYHASAGQSAPVFLYHWAVNTTVKGGASHADQSAYELYNPGIRKISKTQNLLAGYLHAYFTSFATTGDPNAIKGRYADRPRWAPFTPGKKSGTMVIGEGNDERAGGNSIGVVARMGNISYTKEECDFWWKRTILSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB93</accession>
    <name>D4DB93_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP transcription factor AP-1/Yap1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021545.1">
        <property type="nucleotide sequence ID" value="XM_003021499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB93"/>
    <dbReference type="GeneID" id="9578506"/>
    <dbReference type="KEGG" id="tve:TRV_04392"/>
    <dbReference type="HOGENOM" id="CLU_011807_0_0_1"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="643" mass="68844" checksum="2F4B95210F8B68D1" modified="2010-05-18" version="1">MAEFDPSFQRSLYLSPDQQDLLLAALSSNSQPTKPGPQPNHHSANGSSGNDIFDSPPQDIPGSGQLSFNPDDSPFLGLDLDTEFDVSDQALIGDLPGIEGEQQIAAEPREKRKSLDGGEGADTGKKRKENEEKVAKKPGRKPLTSEPTTKRKAQNRAAQRAFRDRKEKHLKDLETKVADLERASQTANQENTLLRAHIQRLQVELKEYRKRLSWISSGNSFSPTTSLLNQARSLHAQSRLNNDFSFDFPKFGDLPGAHMNNMGSLAKGTPNARSQTHPALGIKATSHIGATPQFTPSNGSAFRQNGQSSTANKGHEAPGSTYNSHNFETSPATFSESPSASSESQHISSICTSPESSLTSPTIAQKGDTSNSAQANGNGNAKKNSPSQCELKFYQQLGEACGCVDNPIPAALAKKSNQGSTNPKSPENAASTLSPANSTPTMSTSTASENTNNTQTVSDPSGNGSATASSNVLSDPSIPSFDWLAQQNGGHFDPVLFGDYRDPQDAVLSQDFSGFFDDAFPLPDLGASDAATPGSTTKTTGKTDAPVTTVDIDDDEEVVPGEDRSQMLSCTKIWSVPAVKSVDSNDSSSNPVSRDRLQRLEKFRNGEIDVDNLCTQLRTKARCSEGGVVIDQKDVDDIVTRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBD0</accession>
    <name>D4DBD0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021456.1">
        <property type="nucleotide sequence ID" value="XM_003021410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBD0"/>
    <dbReference type="GeneID" id="9578417"/>
    <dbReference type="KEGG" id="tve:TRV_04429"/>
    <dbReference type="HOGENOM" id="CLU_2252016_0_0_1"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="104" mass="12014" checksum="1AF1C471B6D32F8F" modified="2010-05-18" version="1">MFFIHFLEHVLTLHPSFFGSHVKEYLSQKLLDDVEGICTGDYYIVCVMDMYDISEGKIIPGSGLAEYTIVYRAIVWKPFKGETVRDRDKKHFFIYFGGLFSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBK4</accession>
    <name>D4DBK4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021430.1">
        <property type="nucleotide sequence ID" value="XM_003021384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBK4"/>
    <dbReference type="GeneID" id="9578390"/>
    <dbReference type="KEGG" id="tve:TRV_04504"/>
    <dbReference type="HOGENOM" id="CLU_075141_0_0_1"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="29467" checksum="6ABD2AF140BE8703" modified="2010-05-18" version="1">MSHLAAANAVQPGNHIRSLPLGEPLIHAVSCLLDSSGVPNVLLGNYLLTVYGIPSLSNVRDEWPAATSLGNRGTDILQDASFAVPDDKIPQARKLLNSAAGLVSCTDQNCIIVTVRSRPPPINHFHLDTEDTHIYLYPLSEVLPNIPSIPGAGDKIISASDLGCLPGPIIGYGKGVFAPEYSSVRVPSFSCFLEVCLVNYAHLARGIEDNPGCCYDLHYMSWASYLVQYVHSRGYLNLDLLQPVFRDFMINGFLENSTAGFVTAREKLIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBQ1</accession>
    <name>D4DBQ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021345.1">
        <property type="nucleotide sequence ID" value="XM_003021299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBQ1"/>
    <dbReference type="GeneID" id="9578177"/>
    <dbReference type="KEGG" id="tve:TRV_04552"/>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16317" checksum="F53CCB3788B4F702" modified="2010-05-18" version="1">MGRVRTKTVKKSAKSIIERYYPKLTLDFETNKRICDEIAIISSKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEISALDISQTESGQLDVDADTKDLLKSLGFDSLKVNVTPVSQQTQNIDGRRFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBV7</accession>
    <name>D4DBV7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain (Tctex1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021295.1">
        <property type="nucleotide sequence ID" value="XM_003021249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBV7"/>
    <dbReference type="GeneID" id="9578140"/>
    <dbReference type="KEGG" id="tve:TRV_04608"/>
    <dbReference type="HOGENOM" id="CLU_109453_0_0_1"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="12643" checksum="5A4CB09F3618C4A0" modified="2010-05-18" version="1">MRFHTGGCRANQVLRSLISSISSEETDKEEDSKPDPSKPTYRFNVTCTIIQQGFSSKEGSTNVEARGRRGMHCASGAYWDTKHDGMWTYKHPVAEEKGMDLVLNIVWFGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC11</accession>
    <name>D4DC11_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021231.1">
        <property type="nucleotide sequence ID" value="XM_003021185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC11"/>
    <dbReference type="GeneID" id="9578076"/>
    <dbReference type="KEGG" id="tve:TRV_04663"/>
    <dbReference type="HOGENOM" id="CLU_045137_0_0_1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33224" checksum="2CB5CEE451B8DCD3" modified="2010-05-18" version="1">MLYRTAAARSVLRAVSSSNASIARSAWTNTAFKAQLTTSARQWAGPRSTSMALSPFRQPVTTALVRYSSTEAKKTLIEEPDVDMMAGVKNDVKIIKDTFSLEGVPKEALYYGLAGVVPYVVTSLQTVFLSWEMNNAVTLGTTQYISVETAQAMMNLIEPIQVGYGAVILSFLGAVHWGMEWAGYGGKHGFRRYATGVVAPAVAWPTLLLPVEYALITQFFAFTFLYYNDTRAAVKGWVPAWYGMYRFVLTFVVGAAIVCSLVGREQLASHFTSEHGITEKIKALQAAREKDLAKAEAAAAEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC98</accession>
    <name>D4DC98_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021136.1">
        <property type="nucleotide sequence ID" value="XM_003021090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC98"/>
    <dbReference type="GeneID" id="9577979"/>
    <dbReference type="KEGG" id="tve:TRV_04751"/>
    <dbReference type="HOGENOM" id="CLU_2387756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="94" mass="10452" checksum="D71BE76F2AF4E4D4" modified="2010-05-18" version="1">MSQIADEEDKISRTLFEEFICALVSGLEREKLVVQCVTRSSSYPIQSPERAEPGISRRGKVPRTWKGVLAPNRRQKALAIRNPAGKKQQAGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCD7</accession>
    <name>D4DCD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021117.1">
        <property type="nucleotide sequence ID" value="XM_003021071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCD7"/>
    <dbReference type="GeneID" id="9577959"/>
    <dbReference type="KEGG" id="tve:TRV_04790"/>
    <dbReference type="HOGENOM" id="CLU_403957_0_0_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="10">
        <location>
            <begin position="257"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="466"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="681" mass="76498" checksum="360A5E7679088549" modified="2010-05-18" version="1">MASGESGRRQSVYKIFGEPVRINVCLLSRHFAAAMAARLCWLLIWTGTLAKSPLRLPHCSRHLALSTLHLVFLLSVSAVLVFSVSFVFIIVFILRRDEEQDGEDEDGDGGVKPLLSNTASGNMECGGSRVYNKGESPFSPVHEGVYTYPRPTEEGRKTRRQEDCSKNTRNACKEGTSSLWTTKRMNSPPVVLGSIQEARRASYIKAAALYPDPLLYTRALSVSIFFKASSAYHPCPEESPAAHDGKHRTLERPANSKKNDDAKICVVMVGLPARGKSLIAGKAKIFNVGQYRRQDTPRPTAAFFDTSNLDGERLRRAAAEAAVTDMLHWFSTTGGQVAILDATNSTKERRKWIRDVCQSAGIEPLFVESKCDDRELIMNNIREVKTTSPDYVGQDPEVAAQDFMERISNYEKVYQTIEEDEDVSYIQLINVGTSVVINNIKDYLSSRLVYYTINLHIKPRSIWLSRHGESEFNLSGQIGGDANLSSRGEAYARALPSLLKESGVPPGTKIVIWTSTLKRTIQTARFLQAETGYDKLEWKALDELDSGVCDGLTYEEIAERYPEDFKARDDDKYNYRYRGGESYRDVVIRLEPIIMELERSENVLIVTHQAVLRCIYSYFLNMSQEQSPWMEVPLHTLIKLTPRAYGTEEKRFKANIPAVSTWRGKGSSAKHQEPACQPVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCG7</accession>
    <name>D4DCG7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021070.1">
        <property type="nucleotide sequence ID" value="XM_003021024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCG7"/>
    <dbReference type="GeneID" id="9576717"/>
    <dbReference type="KEGG" id="tve:TRV_04820"/>
    <dbReference type="HOGENOM" id="CLU_053880_0_0_1"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="321" mass="35619" checksum="B822AC73EDE18CDC" modified="2010-05-18" version="1">MSPAQDEADALLDPKDKQPAAHPEDLAHFSGDEYKDDDEEEEEDEHNEKRTNRIRAAHAAAGDDSDESEIDFSGTMVSKPAAYHIPATVYDANTGPKGVIADAQSFERAKKRSFRRTLTSASAFDYNPFSRSGHNSPGASEKHSKSGSTSNFIHRGASPGDSAEESDEDERFMRQWREARMLELQNKSTRRVSPSKRRYGNVDTVDATGYLDAIEKVTPGTVVVVCIYDPESTESSIVEDCLTSLARKQATTHFVKLHYEIAEMDHITAPALIAYRNGEVFATIIDVMKQLPDGRGCSSASIEALLMQYVNIPPIHIYFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDA2</accession>
    <name>D4DDA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020802.1">
        <property type="nucleotide sequence ID" value="XM_003020756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDA2"/>
    <dbReference type="GeneID" id="9577553"/>
    <dbReference type="KEGG" id="tve:TRV_05110"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_3_1"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28435" checksum="60D21819F97D05B9" modified="2010-05-18" version="1">MGEPTDKANPEVPNTIVADGTPVQLEATGDTDQGLRAWTVVVGAWCVNLCGFGWVNVPPAAVLLYLQHLLDSILTAIFDNYGPKLLLLIGTVLQVLGLMMTSISNEYYQFILAQGICGSLGASLTFYSSIASTATWFDKRRALAFGLVSSGSSFGGAIFPIILSRLLPGIGFGWTLRVVGFLVFVLLVIANLTIRSRVAPVPRPVKFHDYISPFSEVPFVLLTVGSCLGFFATFVPINYVILEAQTSGVDPNLAGYLLTILNAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDA7</accession>
    <name>D4DDA7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000260">
        <property type="protein sequence ID" value="EFE40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020781.1">
        <property type="nucleotide sequence ID" value="XM_003020735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDA7"/>
    <dbReference type="GeneID" id="9577532"/>
    <dbReference type="KEGG" id="tve:TRV_05115"/>
    <dbReference type="HOGENOM" id="CLU_537694_0_0_1"/>
    <dbReference type="OrthoDB" id="4173886at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="532" mass="58219" checksum="EEC013264BAE99C2" modified="2010-05-18" version="1">MPSDTQLPPKGPMYVLPAFLTDSRGFTDLEYSKPNQLPTPRGEKRNADGTIKEQPGQVSHLGMAAGDTTLPSDTLALAPEGQDRDMSEFSGGYDTEGEFGADEMEEDEEEDEEDESERDDEDKQQDTEGKKNGRRPDRDFGPGNGNGNGNSNGNGNGYGNGGDAGDDGYEGDSDDSGASTDCNFDDDESDGAPVFEPNNDGEVPSLDSVDPRTFGEIVFDTIESHMQTRVWVPDEESIAMIENETEGNSLFQNNAFQLPGEGSSSSESVHYYDLDDLYYAESVEETSDESNEDSEGNGSDNEFEAQIEEARNEDGDEAATSSVSTDDTHADDNSNDDMEYNDDTPYPHPIATEDMNTWYTDPILANVISHEAFNRLFPGRNITGSQQNAASRTRIWEDEPEDTPEDLPEQPTSPIIIDDLDTPSTSPGPEEENKENKYPESDTPEMESEVENGILEESAPGPSSSSNPQPWLNRYSPVEPRERQPMFFGADLRPVPSLAGRVPVLNVNPNGPRTQVHEWFGGVGANIQDVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDQ5</accession>
    <name>D4DDQ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000269">
        <property type="protein sequence ID" value="EFE40017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020635.1">
        <property type="nucleotide sequence ID" value="XM_003020589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDQ5"/>
    <dbReference type="GeneID" id="9577333"/>
    <dbReference type="KEGG" id="tve:TRV_05267"/>
    <dbReference type="HOGENOM" id="CLU_040940_1_0_1"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="321" mass="36310" checksum="F065B4C7137D8CB5" modified="2010-05-18" version="1">MAPLSQESKNAIERLRRYTPPPTNYYSMPSTRQASVLLLLFADRRGDLRVILTIRASTLKSYPGQAALPGGKADGPSETPFQTARREAYEEIGLPNIDQQMPSPFWVEHLCELPASLARTELAVRPCIALLHSYNEKTGEDADPEEAFIPQLDAKEVAAVFTAPFHNFLKVTDEPREEGDDALPGKPSDWYEGSWTQWNSTQWRMYSLLTGSVHHFFVAITNQRVATPKKHSKEQDDAINQLEEEKSSLGLERFRVFGMTARILVDAARVAYDEEPEFEHNSHLGDEDMISRLRSLGRFSEVVDREDTLTPEIFEKAAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDX8</accession>
    <name>D4DDX8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S cyclosome subunit (BimA/Nuc2/Cdc27)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020555.1">
        <property type="nucleotide sequence ID" value="XM_003020509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDX8"/>
    <dbReference type="GeneID" id="9577262"/>
    <dbReference type="KEGG" id="tve:TRV_05342"/>
    <dbReference type="HOGENOM" id="CLU_008850_1_0_1"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="769"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="91353" checksum="92D6C14BFA1C7D3A" modified="2010-05-18" version="1" fragment="single">LTSSPLTSQLYRPRKKKKQLPSMAPSGPHIASQLRQLIYYHLDNNLLRNALFLAGRLHAFEPRSSEAAYLLSHCLLQSGQPKYAWEVCRNAGSRGTHLGCAYVYAQACLDLGNYMEGITALERSKPQWTSKNNWNKHSENRRQHLPDAAAVLCLQGKLWHAHKDIHKAVDCYVEALKLNPFLWDAFLGLSETGANVRVPNIYKMTPEMVAMLTPSASESSFSEKSIANSQPLQAQPSANHNVDPFSSTNGTSYGSSALWEKLNGSSVSVASAVLPEGLETPITQSDSDDFRVRTGPNTGDTYGEPPFAPARKSRTMQVLGVESCVDPPRLKSNSTRSRSKPKSASAEEPVPSKETTSSQQNASAMERKRTVSGHIAPTNTAQQPVEPGAPQRRSVRLFNQIRPTSKFSTSAASLGTREGREIKKAKSTSSKSRSTATAAPLGRSTTSSRKHGGESTETDSKESRSNGTSSESLNGPSRPQVPDKSKEIDALAWTLDLFSRLASGHAALCSYRCQDALQIYNSLPQNQRETPWVLSQIGRAYYEQALYSDAEKYFSRVRTIAPSQLEGMEVYSTVLWHLKNEVELAYLAHELMDTDRLAPESWCAIGNSFSLQSDHDQALKCFRRATQVDPAFAYGYTLQGHEYMSNEEYDKAQDAYRAAIKANPRHYSAWYGLGKVYERMGKLRFAEQHLRTASNINPANVVLICSIGLVLERQNNLKAALLQYSRASSLSPHSVLARLRKARTLLKLNEVNLAHIELKVLKDVAPDEPNVHYLLGKLYKMIQDKGNAIKHFTTALNLDPKAAQFIKEAMESLENPDDVDDDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE58</accession>
    <name>D4DE58_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein PTH11-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020458.1">
        <property type="nucleotide sequence ID" value="XM_003020412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE58"/>
    <dbReference type="GeneID" id="9584222"/>
    <dbReference type="KEGG" id="tve:TRV_05424"/>
    <dbReference type="HOGENOM" id="CLU_006746_1_0_1"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="943" mass="104165" checksum="544D4234AC5C1F35" modified="2010-05-18" version="1">MAMELDHESDHGHGVAMFTVTLVVVVLSACSVVLRLASRLYLRQAVKIRDYMIVLAWITAFGLSFSILYGTYKGFGIKVDFIPPDLRSLLKKGLYAFSVLYNPTLMLIKTSVLLYYVESIPKTRAFRLATYATLFVVNAAGLALLLLNVFRCKPIRSAYTYPAANESVCTNFVDLNLASVPLNVVTDFAILVLPLPVLSQMTVPFSHKTAVALMFTAGAIFTTITLIRTAMLQHAHIAQVQAKEAVEWDGVDENEFPWHASESFMWSAVEVNVGIICTCVPMLKQLASRLFAKFSGKSHRFASRRDIKEKAPMRRPFDRRDSVTSPSLVFDENRRSCSPDSGYSDVDVQASCRESRSKRCHSHHLSQDSFHDRGAVKPKRTKSMLELTNKEALPFLTAIIFLRFLWGFGYGLLNTVNFRFLIEAKATYAKAIGLHAAYFAGYLIGPAVAGYLLKKTTFKLTFIVGLCLYACGILISWTSAVLTSFETYVFSNVVTGAGMAIVQTTSHPFLALCGPQEYAEMRLNIALGFQSIGSVISSILAKKAFSLRTIDAHDLVQMKWAYFAMALLHIILAIAMHYLSLPEANDNQLADLARQRQMANSAKIYDIRVVWVTLGLAVFAQFLFVGGSEGINVHFRKLARRTRIKNVTPFESQALGFALFAVGRFATVALQLVAKPRVILSILYLGLIGCAIAAVTIHGRLAMIGALGTYFFGSGIYGLTFAIALRGMGHHTKTASAFLTAAVSGGAVFTCVQRAVANSRGVQFSFIVPAVLFTACLIFPIYLNTFAPAKRHTDPTLKNHRARGTSVAFHPTQNDRGEGFAVPESIFPSQETIARVVQKSQDRSSAHIPTSPTQAPKRAKGHYRSGGLMHSLSSWHASLRSPTSDRASCEPSRSSGRWDRSSKSERRWPPGPSSPSVELDRVNARQSSDYYYYRSGEVYKDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE95</accession>
    <name>D4DE95_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromatin assembly factor 1 subunit A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000288">
        <property type="protein sequence ID" value="EFE39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020442.1">
        <property type="nucleotide sequence ID" value="XM_003020396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE95"/>
    <dbReference type="GeneID" id="9584184"/>
    <dbReference type="KEGG" id="tve:TRV_05462"/>
    <dbReference type="HOGENOM" id="CLU_013392_1_0_1"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="351"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="10">
        <location>
            <begin position="561"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="617" mass="69891" checksum="A7F7973022E4D147" modified="2010-05-18" version="1">MTEVDVRPGMNGLPASRLTPDPPKKRIFEELETTSQPSSTPTVQSNVDSAVDSHSSSNHDPSPINAGPVPADAIPQASNDITTSETPSTPKEKPANPNKKRKLSPASKEAKEKQKAEEKAKKEAERKAKEEEKRKRDEEKEEERKLKEKEKKKREEEREEKRRQKEEEKQAKEDEKRKKEEEKQRKERSQMKLNAFFTKPKATPSATTGNETNSAGTTTNLPSDSATRASKPASDFELEFPPFFIQSHVKLAPNHRFERDSSALSHACEKLDNLRKSDFGLANDDIPLQRYNPAELFQMISYRRRQGELATPSVKEILLKLQDPDLNSINLTDTNGTATQVEKLLRKIPMKVLNFREDVRPPYQGTFTKRLEQRAARKLCRNPFWRGVPEFNYDYDSEAEWEEPEEGEDILSEGDDEVSDDGEDDMDDFLDDGEDESANTKRRMIVGDLEPKCTGICWAEDSADNPIINQHRMEIISENITFPIDPFSTQYWETKPKVSPGNSAFKVPHRPSTGKTPSSKSQQQSLLSPSSAAKSSKHLTPMVVVPVSKPKPRIQFPEDKLDEFKEAVSGSNLTKAGLIEVLKKRFPKVSKDVIKETLTILAARQGQKEVDKKWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEC5</accession>
    <name>D4DEC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_05492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020374.1">
        <property type="nucleotide sequence ID" value="XM_003020328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEC5"/>
    <dbReference type="GeneID" id="9584155"/>
    <dbReference type="KEGG" id="tve:TRV_05492"/>
    <dbReference type="HOGENOM" id="CLU_005513_3_0_1"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="448"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE39756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="798" mass="90127" checksum="6AD2E4C45B4A79CB" modified="2010-05-18" version="1">MARLSQAELSVIAKYPLADSLDGVRGLLQEAERPSRTSYDDGADEEGPNEPRQAAVSKLLVTLMGEKAAFNLKPRTSSKNVASELSRLFTRVQEGDFCYEDYRSLAQLALQKASDSDIWNAVLDLITTISPATPPSIPPTFDSTPFRSTSSSQRGSEQTRRLVEERLFEEIKDCTHRNVEGFFKKYFEGKDWNTQANSAARRALGSGDDSRWPSFPDPPAEKDALDWWFGFQDEFLSDARSVYFTTASKSDLTGSDADRQIDLLLRDRSAGDIGRKHNWKDIRVVGELKKSEAEIRSKGALLQMARYVREVFKAQPTRRFVHAFAVCGTKMEAWIWDRSGPFSSGSFNVNEDPRLFYQMILGYAMMTDEELGLDTFITQDDSGASTITVETVSGEETVVQLNSKLLTYQSAIVCRGTTCFLADVDDKVQGVAKFSWTSDKRASEKELLKLAQERGVRGVAEVVAFRDITDISTLRDGLSFKKRHVFKSSSRRASSFRPSHSNDPRSRSSTRLHPSTSDKQTSRKRKSPDKSTQASKRLRGQQENEVTFEVQPVGNHPSLFDMDGEELYDNRIFRCLVVSPAGRPIYEYHSPAELLESLRDAIKAHRSLYTQGNILHRDISENNIIITNPETANGHSGMLIDLDLAKEIGTRSGARRRTGTMEFMAIEVLLNVDHTYRHDLESFFYVLIWQCAHNGWIRFNRPKEMPGRSLLNRWYTGSYIDIATAKTGHMGAKTFEYLLREFPPELETVKPLCRTLRQVLFPIHNGDIFTGTPIKTDMLYDAILEAFDKGIEDIKAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DED8</accession>
    <name>D4DED8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020387.1">
        <property type="nucleotide sequence ID" value="XM_003020341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DED8"/>
    <dbReference type="GeneID" id="9584146"/>
    <dbReference type="KEGG" id="tve:TRV_05505"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_5_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="334" mass="36975" checksum="BAD58CCD705884A2" modified="2010-05-18" version="1">MSRIIAIVGATGNQGGSVARSLLQNQSFKVRAITRNPSSKASQTLASAGAEVVQANGFNNEEMLRVFDGAWGFYVNLNSDDKIWSNPDGPTEFDLGKSIVDAAAQAGVKHFVFSSGPPCTEMTDGRVRMKAMDSIIAVKYKIEQYAKQLGKFLTITPINAAWYLENFLVKEVAPVFGGFPHFPDDEGYLTYRVPNWGGDNKVPFLSITDDYGDIVQGIFLDPVRWNGHVVQAMSEMLGFDELVANFADLTGKKTRFQPILPSWEAFETHGVHELEDVKLMFGFTQITGGRYFGPEPSNRDTASELKRATATALGRPKNQQELTTAKDWFKLHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEF4</accession>
    <name>D4DEF4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020403.1">
        <property type="nucleotide sequence ID" value="XM_003020357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEF4"/>
    <dbReference type="GeneID" id="9584129"/>
    <dbReference type="KEGG" id="tve:TRV_05521"/>
    <dbReference type="HOGENOM" id="CLU_785503_0_0_1"/>
    <dbReference type="OrthoDB" id="4149149at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="371" mass="42412" checksum="67CF4543A28697EF" modified="2010-05-18" version="1">MTSLQHNSIMQQTNAWRRAGAPLLGCNEGDVCDEETRRDVDLMILDYIVCAALTSILHERIADRQGAEQQQEGTHGCDRWLEIAEATLHLFKTNNPGETLSDDIKFKIKTLNFSNLFFRRFKRTAYLPSRAALAAQRKKSRERARRWLEENSFQETTPAEELDRAFEHVQPISASQIDENRRTLLDHMAVKETEDYQFDIEASVTLCDILPELMELCDSAPESVSDDICTVAVLFMLHAAIEQGLLYGRVGREVLDETFAWGNQDDDHSWAETRDRHRLSLCPNVDDAAEGNDDDDDDGDADEDYGEQLKRIIYENPPFEFEGEVLNLIKTLQQTWDAPILNQLEQGKLYSLGEDEVAAFKRRVVFNDFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEX3</accession>
    <name>D4DEX3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000314">
        <property type="protein sequence ID" value="EFE39591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020209.1">
        <property type="nucleotide sequence ID" value="XM_003020163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEX3"/>
    <dbReference type="GeneID" id="9583989"/>
    <dbReference type="KEGG" id="tve:TRV_05714"/>
    <dbReference type="HOGENOM" id="CLU_2005565_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="124" mass="13542" checksum="83FDBE0DF6B64151" modified="2010-05-18" version="1">MRILSPLACKRPFDSIRSVVSSLVSPSSACYLPLSPSNWREGKRAIVSESGYLLIILFPMTLAPWPSSRDFFFFSFFALKCAAVHHVHVHAGLSCPISSPSFLPPPPANSLQALTVSSFTTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF75</accession>
    <name>D4DF75_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000335">
        <property type="protein sequence ID" value="EFE39502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020126.1">
        <property type="nucleotide sequence ID" value="XM_003020080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF75"/>
    <dbReference type="GeneID" id="9583890"/>
    <dbReference type="KEGG" id="tve:TRV_05820"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="102"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="292"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="763" mass="86435" checksum="24457401A00A6D70" modified="2010-05-18" version="1">MAARSDSENASRAKRLKTTAESDPRSNPYLAHMYENEDASSGINDESPLAAFRRHETTAEMANEVESGSVNPFTGKPFSSRYVSILKTRRDLPVHQQRNEFLKLYQESQILVFVGETGSGKTTQIPQFVLYDDLPQFRGKLVACTQPRRVAAMSVAERVANEMDVKLGEEVGYSIRFEDKTSSKTILKYMTDGMLLREAMHDHDLKRYSTIILDEAHERTMATDVLMGLLKEVVLRRPDMKLIIMSATLDAQKFQRYFSDAPLLAVPGRTHPVEIFYTPEPEQDYVEAAIRTVLQIHATEPEGDILLFLTGEEEIEDAVRKISLEVDEMIREVDAGPMKVYPLYGSLPPAMQQRIFEPPPPPRKPKGRPGRKCIISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEGAFKKELIEQTYPEILRSNLSSTVLDLKKLGIDDLVHFDLMDPPAPETLMRALEELNYLACLDDDGNLTALGRLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQIFVRPVAQRKRADEMKALFSHPDGDHLTLLNAYHAFKGPEAQANPRQWCHDHFLSLRSLQSADNVRLQLQRIMEREEIELVSTPFEDKKYYENIRRALVAGFFMQVAKKESQGKNLYRTVKDNNEPVLLHPSTVLGYEAEWVLYNEFVLTTKSFIRTVTAVKGEWLLDISPAYYDISSFPKGEIRSALIRAGERLSRKEKMRSDASKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF79</accession>
    <name>D4DF79_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020052.1">
        <property type="nucleotide sequence ID" value="XM_003020006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF79"/>
    <dbReference type="GeneID" id="9583815"/>
    <dbReference type="KEGG" id="tve:TRV_05824"/>
    <dbReference type="HOGENOM" id="CLU_004222_0_0_1"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="106"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="652"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="949"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137499" checksum="0D38789235EE4F5F" modified="2010-05-18" version="1">MEVDSVSNRSQRPRPPFGDAQNRANMAHPNLQRSRHITLSPSFEKLNLDGPDSKPNEIMETTLTPVENKRISAIVEGQPNSNRNSTISTASTTSTKSRRKTHIGPWQLGRTLGKGSTGRVRLAKHAVTGQSAAIKIVSKRFAAMVQSQSIMVMDKVSRIPGLTKESRAIPCGIEREVVIMKLIQHPNVIGLLDVWENRGELYLVLEYVEGGELFEYISEHGPLPEIEAVRLFRQIISAVSYCQRFNICHRDPKPENILLDGSFNVKLADFGMAALQPEGHMLNTSCGSPHYASPEIIYGKPYRGDKADIWSCGIILYALLCGFLPFDGGDLRNTLKLVKKGEYMLPPWMSEEAIDLVQSILQKDPENRITLTGMWEHPLLKKYENHPLLKSGLAIGLAPPLPLRMYSKVANKRQDINVEILRNLQTLWHAVDSEELIEKLLGEEGNLEKVFYRTLQKFREAQLEASGELPLKHSSSDYHHAPAAHIKGLFTPPQSWKGSRFSLARGGSLKDGTYREPSSLGTISTYDPYRSSQTPTPNPRAEFANVTIHRRPTRMTGTAPSPSPNSPSLTPGPPSSYTVIQGFSSQKTSLASFRSYSSLGSSRCRATGSKHIRYRRNVSFRHLHNLSGSYTPVRKRASTSASQYSLCPSQPATAQAAKAQTATKLQGQSPDHADSPTTPTPPLMARKRDPAKRDNVAISKARLSWREDARKVSAELEKLCEEAFNQVSDSSSATKGPSESKGASDTSSMSSISSNGEPEPKVEAIKDLLPKQPQESPRTYAALELAEARRRLIEHSAQAGVNGLPDYLKNVIAHLDRLIDGETASSGSKPMTKQTLVARESTGRLPVISEENYFEPESKSFLPPPEPTKPLDLGLDNWETKKSIRVVNNDSMKTNPDSVTSLTVQKKQTGELPSLDCAFKSFEFSGYLAPGCNEDDVSSPRDMVVRHDSGLDSIDENPNSARSSAARNSDEAKKWTWLKPRQNSSDTTDTEVSRDKPFTDLLDRMQEERRKSAFSNIEQHFRDLGATAGGLRLKKLFRRKKAPGRIHKLTDEADETDVTSTISDTDSKPNDSGVELDDDSTAATTPMRKNSDDIPLTTASYTNTWFSRFMLMKPAFKVLALNISKPRAKKEVVKIFKEWKKYGLEGLHLDNQNDIICGSVGELNFLRLRPVQFSAEFFSVLEHGRHANLSLIRLRQDQGASSSFYKVVQTLRMALKERNFLVQDTRRAKKMIKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFE2</accession>
    <name>D4DFE2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="9" type="ORF">TRV_05889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020115.1">
        <property type="nucleotide sequence ID" value="XM_003020069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFE2"/>
    <dbReference type="GeneID" id="9583879"/>
    <dbReference type="KEGG" id="tve:TRV_05889"/>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="289" mass="31242" checksum="6C5FD92A391550C6" modified="2010-05-18" version="1">MAPSNLPPVFNATSQDMEMMLTAQCHLGSKNMQTHMEPYLWKTRPDGVNVINIGKTWEKIVLAARIIAAIDNPADICVISARPYGQRAVLKFAAHTGAVAIAGRFTPGSFTNYITRSFKEPRLIVVTDPRTDAQAIKEASYVNIPVIALCDADSPTEFVDVAIPTNNKGRHAIGLVWWMLAREVLRLRGTLATRETEWDIVVDLYFYRDPEAEETKEIEEAKAAEAEEAAPEALNPADTWDAAGAAAPAAFGAPAAATNWEASNTDWATSGAAAGESWAADAAAAEPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFE7</accession>
    <name>D4DFE7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000337">
        <property type="protein sequence ID" value="EFE39409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020033.1">
        <property type="nucleotide sequence ID" value="XM_003019987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFE7"/>
    <dbReference type="GeneID" id="9583801"/>
    <dbReference type="KEGG" id="tve:TRV_05894"/>
    <dbReference type="HOGENOM" id="CLU_1908186_0_0_1"/>
    <dbReference type="OrthoDB" id="4194484at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="133" mass="16135" checksum="6CF4D73A8BD6B414" modified="2010-05-18" version="1">MGFLNWWSNLRDSMHSVKETETRTAHRLAHSPPELWSSRDHIASRRLRFRRELALKKAKKENRSIVPVVMRYPEGPYWPYTIEDDMGEYLKAYKHKRKIDTFRARHPHLQIHQTDENTFHAYNPWNGETFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI4</accession>
    <name>D4DGI4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_06288</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019659.1">
        <property type="nucleotide sequence ID" value="XM_003019613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI4"/>
    <dbReference type="GeneID" id="9583576"/>
    <dbReference type="KEGG" id="tve:TRV_06288"/>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="389"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="916"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131519" checksum="52BFA1AAC5440A4A" modified="2010-05-18" version="1">MYHVTLGFGLRFEHDFLLRDATVWALDLSQAPTPRVRGLRTVSTNVAFNRTWLTDLDDFVGEDGEEYGASGFGGFGDYFRRKKIKLQNLDSEIRSASPNNPPIFKGVVAHVNGYTQPSLNDLHRMIVSHGGGFLQYLDRKTAATHIITSALTPKKKEEFRRYRVVKPAWIVDSIKAGRMLPWETYRLLGEGTAQKVLKFDANGISTENNTQSQSYKAQTDACWYTSQLNKEVVPVDSQRIVELPSADTTDDPPLEDEPATDVQATDQVNGVSMASTTPEEFGALGSDDLLSPVHPERPSLDQVHTSPKADGRKPLTSEEHNALLLSKAHIRQSSVINPDFIQQYYRESRLHHLSTWKAELKAQLQTLAQERGTAKLSPIKRLPGTRRYILHVDFDSFFAAVSLQKHPELADSPIAVAHGTGPGSEIASCNYPARKFGVKNGMWMKGALERCPELKVLPYDFPAYEDASRKFYQAILDIDGIVQSVSIDEALVDISSLCIQAGGSDGKAISESSIYREQEKADTIAQKLRDSIKQKTGCHVSVGIGQNILQARLALKKAKPAGQFQLKPENMLDFIGEFSVTDLPGVAHSLGTKLEELSVKYVKDIRQLSREKLTGHLGPKTGAKLWEYARGIDNTVVGEQVIRKSVSAEINWGIRFTNQAQADEFVRSLSEELHRRLLENGVKGRQLTMRIMRRAADSPVDPPKHLGHGKCDTFNKSIILHTPTNASDIIGKEAVSVLRSFNFSPGDLRGLGVQMTKLTPIKATASGEHTSSQQQLQFKAATPGPKSIISQDPDEIMSLKKGENASPHISASLAIGSSLHDASQKLLNTRGTQFILPTQSDPSTIAELPSDVRSKLAPKERLSISEQLKAAASAKRPMQTLFASTALPPESQLDQDTLNALPEDVRAEVLGYYKQNANTPTIASPSPTPLPKSPRHRKPTTPTKPKSSRGRGRPRAATRSATGPTLTQSNFIIPQVSLPTHECTNSADNSPTRASADPDRDISEEFLAALPEDIRREVLEEHRQTRIQEQGGLNLAAVHEKNSRIKQHRTNNSSLPVEPEQKLLRFDPRPAKPTFTSKRLSSLSEIREALSEWYSSFENEEPYEEDVEALTKYLRRVVLEEKDISKATDLARWLGWLVNDFNSSCHGSTGDTGPSSKSSPSLSGWKNAVIKVQNCVSNAVVERGLPPVDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH86</accession>
    <name>D4DH86_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000374">
        <property type="protein sequence ID" value="EFE38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019427.1">
        <property type="nucleotide sequence ID" value="XM_003019381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH86"/>
    <dbReference type="GeneID" id="9577882"/>
    <dbReference type="KEGG" id="tve:TRV_06541"/>
    <dbReference type="HOGENOM" id="CLU_2689586_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="74" mass="8707" checksum="1804EEC82D981808" modified="2010-05-18" version="1">MSCLPLISGLQGWKKKEQNFPRLAISLIFVTNILLIKGPHGFGHVQREGWTETRKTDDVKEEEEENTWERQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH95</accession>
    <name>D4DH95_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000375">
        <property type="protein sequence ID" value="EFE38774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019419.1">
        <property type="nucleotide sequence ID" value="XM_003019373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH95"/>
    <dbReference type="GeneID" id="9577874"/>
    <dbReference type="KEGG" id="tve:TRV_06550"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="511"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="888" mass="99362" checksum="E29B0A0A6096940D" modified="2010-05-18" version="1">MFWKRSKTDKQQQQSAAPSPPRQSGLSSVPESYSRPISHSGTQTPVGIDDDAKYKAIIKYLHARLATSKWCPPPSDPNSEYHGLLLRKSRGVYISEPDLVHPLLLGAVQKINVAVAFTMATEITRIIFSILQPDQTELILPSGFQVQVVESLAEIACSPSSAVKKFQYVALVREERLLLIWHDELEKILIHAEDVEEKLLAFSPSYSLPHSSIGSPAASTRNFVPLWNKEASGLANSPLGIAVEEAAKPIESLDRPLALTSSIFVGLGMCLIVVLLVGFGVSNLMLQPLVDGSWLRFALVASLPIFMLFSVFFVIVIFSDIFQAIGPIKTLKTNSRFYSPVRPDLTQAYALGFKPPRITIQLPVYTESLTGVIIPTVTSLKAAISYYESHGGTATIFVNDDGLAYLTEEQREERISFYHDNNIGWVSRPKNNQDGYIRKGRFKKASNMNFALNVSNKVEDKLLEMLAETLETTEMIDASQEEAYYKLALQEVLASDSRIKAAGDIRIGEAILIVDADTRVNSQPVDCLLYGAAEMFLSPEVAIIQHSTGVMQVVGDYFENGITFFTNLIYSSIRFAVGSGETAPFVGHNAFLRWKGKPDDGYVAYWSESHVSEDFDIALRLQIAGDIVRLASYHGDEFKEGVSLTIYDELARWEKYAYGCNELVFNPIYTWIYKGPFTKLFMTFLWCNMQLSSKITILGYISSYYALASGFPLTILNYFLVGWFNGYLDKFYIESWKVLLSLIVVFSLLGNVTLAIIRSRLSEKSLWSALVENFKWMPMMAIFFGGVSFHLSLALLSHMFSIKMEWGATAKEKVDSNFFKEIPKIFKSFKWMYAVLIPLIGGMIYLGNFAPRGWEIKEVAAVVPMAVTLSLHALLPLLLNPSLMIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHW2</accession>
    <name>D4DHW2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019220.1">
        <property type="nucleotide sequence ID" value="XM_003019174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHW2"/>
    <dbReference type="GeneID" id="9577217"/>
    <dbReference type="KEGG" id="tve:TRV_06769"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="504" mass="53802" checksum="6EC51C1254F83726" modified="2010-05-18" version="1">MIKEICAALLSADVNVRLVQQLRKSIKAAVQLPSIPPAVNKKRLIQKAVFDQLVALVDPHAEPFKPKKGKSNVIMMVGLQGAGKTTTCTKLARHYQTKGFKAALVCADTLRAGAFDQLKQNATKAKIPYYGSLTQTDPVVVSSEGVAKFKKERFDIIIVDTSGRHRQEEDLFAEMTQIQSAIKPDQTIMVLDSTIGQAAETQSAAFKSAADFGAIIITKTDGHAAGGGAISAVAATRTPIIFLGTGEHMLDLERFAPRPFVQKLLGMGDMASLVEHVQAVTKDSAGAKETYKHISEGIFTLRDFRENITSIMKMGPLSKISSMIPGLSNITSGLDDEDGSLKLRRMIYIFDSMTASELDGDGKVFVDQPTRVVRLACGSGTTVREVEDLLSQHKMMAGMAKKVGGQKKQMQRAQNMLKGGNKEQQMAAMQKRMAAMGGAGMPNMPGMGDMQQMMQMLQGGGAGGGGMPGLGGMDLQSMMSQMSGLMGGMGGMGGGRGGSSRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI85</accession>
    <name>D4DI85_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_06893</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019068.1">
        <property type="nucleotide sequence ID" value="XM_003019022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI85"/>
    <dbReference type="GeneID" id="9582553"/>
    <dbReference type="KEGG" id="tve:TRV_06893"/>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="54740" checksum="69BB7E5F0E25A1C5" modified="2010-05-18" version="1">MGASQRRGPRGVEQPAASGSTSTNFTDGASDEFEFGGSLGAMGVMLGSPLIMWYMWIGATYYDGAFPWPAAGQSWTDFTLHLAHLVYEGGYPTAKAWAIYWVFFVAEALMYCYMPGVSSHGRPLRHEGGRRLPYYCSAYCSFYATLAIAAVLHVTGLFPLYTLIDEFGSIMTVAILSGFINSVIVYVQALVRGRTHRLSGYPVYDFFMGAELNPRIGILDFKMFYEVRIPWFILFLITCSVATRQYETYGYVAPEVIFLAVAHYLYANACAKAEQMIITSWDMYFEKLGWMLTFWNMAGVPFTYCHCALYMAKNHPSEYRWNPIALSALGVVYLFMYWMWDSANGQKNAFRHKERGQLIKRNTFPQVPWQAIENPKTIKTDVGDHLLIDGWFGIIRKPNYVPDMFFSFTWGLLTGFKTMANEYFRSPFPWFYFVFFMIMIIHRTQRDIDRCRRKYGEAWKQYEKAVPYIFIPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIN9</accession>
    <name>D4DIN9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018917.1">
        <property type="nucleotide sequence ID" value="XM_003018871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIN9"/>
    <dbReference type="GeneID" id="9582076"/>
    <dbReference type="KEGG" id="tve:TRV_07049"/>
    <dbReference type="HOGENOM" id="CLU_092848_1_1_1"/>
    <dbReference type="OrthoDB" id="4174425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="169" mass="18132" checksum="26467753CDBDD1CF" modified="2010-05-18" version="1">MSSSSKEAKKASESLTLCDKGQLDGINRGSGDSVANLTRKEASKFSSPESTDSEPTSSSGSSDDSDSDSKAGESSDEEKSDDDEQMDDQPGPSIPSRQFSSLPDNSALRARLASFLPSLKAANEDLEREIAAGKSMTLEVDNEDEGQGQLIEMVRYQSDRSTNRDDTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIS2</accession>
    <name>D4DIS2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000412">
        <property type="protein sequence ID" value="EFE38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018891.1">
        <property type="nucleotide sequence ID" value="XM_003018845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIS2"/>
    <dbReference type="GeneID" id="9580061"/>
    <dbReference type="KEGG" id="tve:TRV_07083"/>
    <dbReference type="HOGENOM" id="CLU_114656_0_2_1"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055605" description="60S acidic ribosomal protein P2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11114" checksum="7EB76E7A5CF15F9D" modified="2010-05-18" version="1">MKHLAAFLLLGLAGNSSPSASDISDVLSSVGIDADSERVEKLLAELEGKDIQELIAEGSTKLASVPSGGAGGAAAAPAAGGAAGGDAAAPAEEAKKEEPEEDSDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIX8</accession>
    <name>D4DIX8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000417">
        <property type="protein sequence ID" value="EFE38177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018822.1">
        <property type="nucleotide sequence ID" value="XM_003018776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIX8"/>
    <dbReference type="GeneID" id="9581382"/>
    <dbReference type="KEGG" id="tve:TRV_07139"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="304" mass="33327" checksum="80ACF0C3193F53BE" modified="2010-05-18" version="1">MSLVGFGRLIQGRLFPPANPTASLEGKTVLLTGGTSGLGLEAAIKYINLGVSSLIIACRSIERGNEAKKVIEQRTKHASSSASFDIQIWPLDMASYQSVTSFAQKINNEVPRLDIALLNAGVMHRKYTLTPDGWEETLQVNALSTALLGLLLLPKLRDSRDTATGAPAHLTFVSSGSYRHAKAGELQPDGVNSILQHLNSEENFRAHSQYRLSKVLVEYTAKSIAALTRCDDGSLGVIVNSACPGFCRSRLGREYDAWHERMFVAVFELIFGRTSEQGSRTLVSATMLGEESHGKWWRSDQYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ07</accession>
    <name>D4DJ07_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIB component B'' Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018812.1">
        <property type="nucleotide sequence ID" value="XM_003018766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ07"/>
    <dbReference type="GeneID" id="9581372"/>
    <dbReference type="KEGG" id="tve:TRV_07172"/>
    <dbReference type="HOGENOM" id="CLU_047017_0_0_1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000322">
        <property type="entry name" value="Transcription factor TFIIIB component B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="186"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="350" mass="39596" checksum="A8D89A4356C14E39" modified="2010-05-18" version="1">MAQPPAAMADTTTAPQKMAKRKRAAEDVAAEVVADAVREKKPRTSRKRASTPENSESIEIVSAVVTMSDLCRDLRTGKTSKREMELRTMDWAEIARKKKEREERKKAGSSGSQSAKGSSMDTPKPAEKKMRPSAEVTGPQMRIVNGEIVLDTSSLQIDRHADADRNADDMEEVEENPLSRRINAASFGKRTKLETWDEAATDLFYKGLRMFGTDFMMISKMFPGRTRRHIKLKFSNEERREPERIKRTLLGPREPVDLAAYSEMTNTVYDDPRAIQRELDEEKKRIENEHAEEQMAREEQLRNPGGKPGDKVLPSIEGESNEARRRREKKKAEQAKFGGGTEEILGSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ6</accession>
    <name>D4DJJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018604.1">
        <property type="nucleotide sequence ID" value="XM_003018558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ6"/>
    <dbReference type="GeneID" id="9584531"/>
    <dbReference type="KEGG" id="tve:TRV_07364"/>
    <dbReference type="HOGENOM" id="CLU_1897703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF178">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="134" mass="14711" checksum="4395001991834ADF" modified="2010-05-18" version="1">MLGAAWTTVSREAEISLENMNGGSALNYLLLGLVNIFWVPIGMKLGRRPVFLITTTICMLTAAWLGYVHGTAQWMTNLAINGFGVAAYQAVIQLSVFDMFFAHQRGRTLSFYLFGQQLGSILGIVSFTLRGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJZ7</accession>
    <name>D4DJZ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018492.1">
        <property type="nucleotide sequence ID" value="XM_003018446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJZ7"/>
    <dbReference type="GeneID" id="9584421"/>
    <dbReference type="KEGG" id="tve:TRV_07506"/>
    <dbReference type="HOGENOM" id="CLU_019189_9_1_1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="558" mass="63583" checksum="203CA1368E05CA0A" modified="2010-05-18" version="1">MPPSANSLLSILGTQVSDDLFTYTSGRYVFNESLRRRERYVRFDVEALKQLAASHINHGKVADITKLAEGGFNRVLLLTMEDGFQAVAKMPYQTALPKYYAIASEAATLELLRTINIPVPNVLGYSASSDNPAGVEYIIMERAQGTQVKEQWDSMTKRQRHKLASSFVEIEKTLFSLPFSSIGSVYFKSDIPAELQAPLHDVPSLSQSDGQDIPEKFCIGPIADYMFWYGDHVCAPFTERIKMATDSSTGSSSTAYLRSIADKEIKWTQQYGKTLELQFPHNGVLTGKQNPDRYVDLLRNYLALAPYLLPREGSELNTPTLRHPDLNPNNIFVDPETCEITCLIDWQHTTIEPRLLVAGYPQAFENPDTDEPLDLEEPTLPPEYDSLESDEKAEADELYRHLLMTHYYRIYTGVLNKPHLNALRDPLLNPRKHLVDRAGRQWSGNTITLKGALVRMVDYWDQLPETKGIECPVKFDISDLDEFLKQEEMWLCFNAVMNYWRDELSISEDGWVSNENYEAAMKGVQRLKQDMLNKAEGDEEDIILINKGWPFDDHEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK04</accession>
    <name>D4DK04_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000448">
        <property type="protein sequence ID" value="EFE37814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018459.1">
        <property type="nucleotide sequence ID" value="XM_003018413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK04"/>
    <dbReference type="GeneID" id="9584390"/>
    <dbReference type="KEGG" id="tve:TRV_07524"/>
    <dbReference type="HOGENOM" id="CLU_013189_0_0_1"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="749" mass="80336" checksum="8FBB1A4D43123187" modified="2010-05-18" version="1">MAQKGGGAWRPRMWSKKSKAKDAVPQRGHVSDSEAQLEHGPRHSLHTVKKHGDLRSIARSHSNEDADDQNSSPAVQAKKPGHSPQGFPECHDGKTDAREPILQGRPFQPGNGQPAQKGQGQGSPSFKGVVIGPSSKKKRSARAPIANNIESLGPISPSRIPFSSSFKSPVAETRTDDIGSASMDQSFFVKIPKTPTHDFDRSRENVGQTPKKEEQVPLQPRSPNISKKINRNPDFRASPKADAKKPTELFEVLDLPRDNDPVAESNNEPDIHDKPTTEEQDPSCTSDTAVIADGMPATSSDFNNYDNKPKTTVNFSRTARLRPSPLSGPPLFSPEPKGSATSNGDTDPICAGIAVQPMATFPTGQGHQLVAESIPAGTRQLSLDRFLRPGRAKKASINEIDTPPAKQAVLDFNAETTNDTKGPGKGHSEGQTSTNVASKSDGKSKVIDSTQGGALSLGNGEQKLAVYDGNTARPHRNSIDIINKLRPSLGKTEAKLKKKRPISAEVNSISTSVEKPPSSHASSPVAPNSPLPSPENTSPGHPSSPASISALRSMKEEGNSYFTKPVGKPWLGSDHISSSSSLLGFSSVSPGSSRGSRPTNSGQRIAKMFVICCKCKFWHDMPSDAYAKLAFPTVAALKNKLITGPTQSSRHSEEDGGAGWPSISEPSSPQPNKMDDETRTSANLMGTGSHGSRQSTNTMNSGKISPPSAFSRFSFLNQSVIKCCWCEHRMSRTCCAGWTALVQLRERHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK51</accession>
    <name>D4DK51_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018418.1">
        <property type="nucleotide sequence ID" value="XM_003018372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK51"/>
    <dbReference type="GeneID" id="9584346"/>
    <dbReference type="KEGG" id="tve:TRV_07572"/>
    <dbReference type="HOGENOM" id="CLU_004498_8_2_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.240:FF:000001">
        <property type="entry name" value="L-amino acid oxidase LaoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055940" description="Amine oxidase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="587" mass="66991" checksum="54BAF90FC9819FBC" modified="2010-05-18" version="1">MAFPLFLTLCFCITVLAHPTYPPNNSKNGPRHGKPLLSDFDALGAWFDGIAALEGTTIPRQPNVTVAIVGGGISGLATGLMLDSIGFHNWEIIEASDRVGGRFRTVFVGGTQEFAEMGPMRLPYTITYKSDNSTHEYTDHRMTFQLAEWLNEMNGYNSTWKIEFIPWVQHHPNELIARGTGRHPDGRVPTRGEIAANPSLGRPPPLVTAEYNNTKEQMNRILKDEKTLRAIQKDIWRAHKWAMDQGLDDYSQQSMMRHVFHASENVTDAIWTSTDYDVFWDEMVHNSNLAQDGSKDAFGETEWKCINGGFNRLSDAFIPHVSNRLVLNRKITKLEPVNDNTNHTRTRLSWYSGTGKNRTSDSKDYDYTIMTVPFTMTRFMDLPKFSSVLDRAMGETGLRFKSACKVSLLFKERFWEKGERPIFGGYSMPESLGIGALYYPSYGLNESRPGLITHYRGGDWSDRFVSMSDEQHTQLVLDAVVSLHGEQARELYTDDFVRLCWLQDEHSATSWCRPDVEQHKLYIPAYHRTEHNTIFIGEHTAPTHAWISSSLHSAVRGSIQLLLELGMVEEAKQLNHRWMGRWIKHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKF9</accession>
    <name>D4DKF9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018302.1">
        <property type="nucleotide sequence ID" value="XM_003018256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKF9"/>
    <dbReference type="GeneID" id="9579998"/>
    <dbReference type="KEGG" id="tve:TRV_07681"/>
    <dbReference type="HOGENOM" id="CLU_026100_0_0_1"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61812" checksum="0A75EFA5F54C1EC1" modified="2010-05-18" version="1">MDGQRSDSSFTDAVIVGNGPSALILSYILHGNIPYYNLDSPHPDPILHAKLRDATELLRLDVARLTNHFEASRFSYSTQSLPINSLVDSLVRPFGETDDRESASCVSWHHDPQRAVPHLCLGDALQPGGQWTECPPGTTWDIQSLSYAGMLSLPGYSFYDHYYATHGVHMPSYTRPSRQAIAEYLAAYPAAVGIGNSIQNGQLVSGVSRTDGGFYIASHRIHCKHLVLASGIFTEVKPARPLLQPLLSLPDHPDVSTTEKAPLLVIGSGFSAADIIISAPRDQKIIHIFKWEPETNPSPLRSCHQQAYPEYAGIYKLMKRSTLAKFTTSKPNKRNQSSLSPFLTTRDWDDIYEALPNTLVVDVEVDGTEGVVTFRCSDDSTITRRVSGLSYAVGRKGSLAYLDHMLQREILGAGFDQSQDASIAKDTLKSAAVNDLEVANDVFIIGSLTSDSLIRYAYGGCIYAAGKLMERHAQRQVHPPPCDGPVDHTVPGQPQPELPTTPSPNTPMNILNHTKFNNKSSNTVPSELRMHRVSSDLKLGSKSDRFGSRRQRPWWAFIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKZ2</accession>
    <name>D4DKZ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-N-acetylglucosaminidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018170.1">
        <property type="nucleotide sequence ID" value="XM_003018124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKZ2"/>
    <dbReference type="GeneID" id="9579541"/>
    <dbReference type="KEGG" id="tve:TRV_07866"/>
    <dbReference type="HOGENOM" id="CLU_008392_3_0_1"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="705"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114084" checksum="BBF5C8ED31A51E47" modified="2010-05-18" version="1">MVLDIGYRQMGQLFVMGFDGTTVDPQIRSLIEDYHLGAILLSAKNLNYLAVRYKTKTNSRIAADETAKLVLELQTIARQAGHQLPLLIGLDQENGGVNNLFDDTYIRQFPSAMGVAATGSPKLAREVAKATAQELRAVGVNWILGPVLDVLTDGKNQPLGVRSVGDDPQEVATYGVESMKGYQDGGVATCGKHFPSYGNLEVMVSQSDVPVITDTVDQLRLSALIPFRSAISQGLDSMIVGGCSMISQGMNVMHACLSEEVIEDLLRSDLGFQGVVVSDCLEMEALSSNIGVGGGTVMALKAGCDLVLLCRSFTVQQEAISGLRLGVENGMISKERIRQSLARVSAMKVRRTNWEQALNPPGISLLSRLRPSHTNLSMQAYNSSITVVRDRGNLLPLSSILEPDEELLLLTPLVKPLPASAAAAVAATAAAAAGHAGGERSRESTNSIDASSSSMSSNMKSGEAVFRELGRSLARRRNGRVLHTSYSASGVRPIHENLINRASAVIIVTADSNRNLYQHGFTKHVSLICNSSCMNNSTNNNSTHNNSARRNSAGYQRPKAVVVVAVSSPYDFAKDPTIGTYVCTYDFTDAALQALVRVLYGEVSPTGRMPGTLSKSTARRTSQPRQQWLVETWNEERDSAALDTLLTSIRESESGINNSSTSSNTHNNEMGPSSSIDSTSTSSTSSILANVRADTFLLKSADVQECHLVVRNSSTHAINGFCATYFFRSTGTGVIGAILVDPARRRLGIGSSLHSRAIQTLRQHPDIKQLQLGSRLPGVYLGIPRTDPVERRRLRRWFAKLGWSMALSRPLCSMVLRDVQSWVQPDGLKGGSRSGSSRSSSSVIGSGEVEYDLVFGEEYTDAVIEHVRTSSRQGVAEVYRTALAGGPHCGIIRAKKAGETSITSAAAAAPAAPANANGNAASANNNHNVVNAGSEEDGDGEMMIDGLQLGLEADDQLHDQLHGHSNDQPHGHGQGHSNKTLVGSVVVYNARSSLARLVPAVREARVRAGGISSPVISPSVGEYAMLVQGLIVLGIKEIRKQGGNTVILDCVSVPSFYFFFFLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLI0</accession>
    <name>D4DLI0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein S13p/S18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_08054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017934.1">
        <property type="nucleotide sequence ID" value="XM_003017888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLI0"/>
    <dbReference type="GeneID" id="9579816"/>
    <dbReference type="KEGG" id="tve:TRV_08054"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17933" checksum="99669862911D6829" modified="2010-05-18" version="1">MSLVSGEKSNFQFILRLLNTNVDGKQKIMYALTKIKGVGRRYSNLVCKKADVDLHKRAGEISSEELERIVTIIQNPTQYKIPTWFLNRQRDITDGKDTQVLANQMDSKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLI3</accession>
    <name>D4DLI3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000509">
        <property type="protein sequence ID" value="EFE37292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017937.1">
        <property type="nucleotide sequence ID" value="XM_003017891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLI3"/>
    <dbReference type="GeneID" id="9579813"/>
    <dbReference type="KEGG" id="tve:TRV_08057"/>
    <dbReference type="HOGENOM" id="CLU_1004613_0_0_1"/>
    <dbReference type="OrthoDB" id="5408144at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="34204" checksum="CC59EB9585C761D0" modified="2010-05-18" version="1">MGLGLRERVKRAIFSSRPGLSSHPSSSRLAERLEQAKEYTIAGPSQNKLQHRHRHRHRHQHQDQHQHQQQQQQHHNQDQMHPPTSPTTKKSFRASIIKTLSPRTSNRKSKIEEPWPKIELYKPHEIPRPKYRGPVDKRHLAVLEAYSIVQATEGYRQRSIDSSVCPLATNLPSRRDSVTSISETVIVRRPGDVEDGVGTGEGAGEVEGDVEVEVEVEVEAQVDDDINIRNTNRDSLQDEEDSNTTSTASSDEGANVSSSTLLTSHTEDEHLQHLQKQQRPSVTRLKRTTAFTAADLHHALNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ7</accession>
    <name>D4DLJ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TRV_08071</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017905.1">
        <property type="nucleotide sequence ID" value="XM_003017859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579783"/>
    <dbReference type="KEGG" id="tve:TRV_08071"/>
    <dbReference type="HOGENOM" id="CLU_000178_8_2_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1847"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2539"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2855"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2815"/>
            <end position="2841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EFE37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2887" mass="323749" checksum="7D46309BC719D306" modified="2010-05-18" version="1">MGEVSVDQAVNLISSGRLKDRIDGLEGDTPVCRPVLIDWLTFCVDLKHILLQNRRSPRLGSLNDKVYHGIFETLFRFIAIEKSTFSKANRAVSKTQAASRLAKCAGVIRTAAEVSLRRIRTKTVIALVNHVIDSLTIPGEGLWESLSADYIKTLRVILQYPPHVEHLSKDVWCDLLEFCLQGLGLAGDSNSLQMSIRRGRSIPPEEFSQSSRSTPHPTSAQSSYPSSKQDSRGSSEDLEVCIQLLVACPGMPVLENAPKLFHNLSKYIASLNPMGSAPHAAFTALNTTLSIAILENITLVQDTLCAVIPTIRRYWSTKSVVLKEEMLATLLIGKEILCRRGQALQPELDIEIIQGIVDRLHSEYVRLPEREALQVDDLIFSHHNIPMHVGLQFISPNTGVSKVMQNWTILSLIAAFSRLIDNYHSREKRDLAEEKSLNKKQHLLSRIDDILMDASRPTGNNRICALQLIPFIVSETEPEVGRLSTLLGQLIKNTLDDNVVVASWSIVAITSLTLCRHAKSDQIKETWLQAWELGVRNISSPAISRAVCHFMAVSIHSKLLSYSDIARTLDSLVSSADMNGPANLNDSSLNLWVNVLELWSEVNATQSQSLVKQAFPTDRVQTSHMATFARPFPLLGILLSCFGASIPNPDLSSTGPVNRISRVWMHLQHHAKILDYLTLTGKKTTVHSEIVGNVPIYVATRHHPSETLVLDLLQYKIDTFHQVWAALCTDKGHHITVEIIQVLTSLCVISIIMMEFIPQSLRSQHTQDSVLKLWASLCDKFSKDEEHLNTCLEVLAPIVLSLKAPFDSKDIILRGLVRMSVLLVPILERDRQSDEINSQASDAMDVDTDFPSQRPAAMESSLISKIHRSDSVVSLFPDSASVRIATSIQLMVICKIRLAEEPCLLLDGPLIGYLTTLTETETLVGWKYVIDVFKGRPDVSRANACRVIEYFGEKCLESYQLEGCESAICACISLVGCFVNLWTGSERDDLFESASELYAWFTDVLLGEGLGSSKVLIRLSDLSESILQANPSHLKETRQASPRTTLFRILRDGDLVVKFHISQLIPDIFSRFVLKEHDAILEDVIDRLPQDSTWAEGIALRLYLFAQLASRWHTLLRQSIYRIFETSGNVPTSIPHAKACLQEISVELGLDGPKEVFQLFTPQILYTWMDKESVTDIPFAVFGYPTLRELLVDIQDEVVGQTAMREKEDDKKAIEACLERTFEDLLCESFYKAEAYSVARDISMPPSQEVGAKGAERGMINLLGKEKFFQLSERYFPQTVATLFGSIDQTEQIQRAFEKRPTFHHALVAWQNIHERSHSASALPLSQQPCFRARYLLDEIEFLCKRSGFDIETMWTPSLVCFVARTLLDSTHAALGSLHTCSVIRKLKILICVAGQILLYDYPFEMLLRGLSPFLTDFHCAEDAIGLVWYLIENGKAYLSDNPSFTAGLAVSILASLREFLSAPQASTTQRAHFKATLAKAHEFHLWFSDFLKTYSPSAEYSTLDGPSTESLRRIIHASQNIQLVGNGIKGTYESELILELLGDKISGRNLLTAHTSNLVLSQLCGSFQRPDTFRDDVLGEDAVAASHAMTLWSSVENRTLGKSFRLWLARVLGRSYAATGVVDPSFRKEQKSEFLDCSHDGFLSGSKIAILRILCDSLSNSSGPAGLAERTLQMISNNITRDLQIDECMQIIPPTLLKALTWEPYQCPMLVFSASAMARFISLPQRDATNTASEFAQHLALFLCNKVANDAVIGALPKIIFEVPSFAVQLLPYILHDVLLSEIDSNQKTRTEVSELFKETLQNSNDSIIPHIRLIITCILYLRRQPLPRENTMGERNGWLDIDFMLTATAASRCQMYKTSLLFLEICHSQAAGASRRSSTIAPPESTELLHRIFKNIDDPDSFYGIQQDQSLDAVLQKLEHESSGLKNLFFQSANFDTDLKLGRNIDDGGAFEMIKALNYTNLQGLSSAMFRSCTPTCASNEAFDHMLSTNIYLQQWDIPVPTTTSPTGTLFKSLQALNSLEDRIQIVKSLDDCFLEIIDRLNQGNQSLSSLKSSMTVLGILTEIDEIIMSDNSSHLQEVWDRLTSRGEWLKSEREAIFSSISRRSHLKKMTNLSSRDAQILEAECIRESLRISTDHGIPQASLQSAMSLSKLVQPCAELGVKIDAATAFDLANVLWDQGEMKTSIKILQNLSGQKDLHSQTIPVSVAEILASLGHHIAEARLEQPDAIIQSYLAPSIKELKGEYTGGEAGLVFHQFATFCDQQLQNPDTLEDFVRLEHLRTRKLKEVADLEEMMKTSDGKTKDQLRTHRTKAKQWFDLDDREYQRLKKSRESFLYQCLENYLLSLTACDTFANDVLRFCALWLDNSDNEQANNAVSGYLREVPTRKFASLMNQLSSRLLDVADTFQPLLSALVLQICIDHPYHGMYHLFVNSRSKKDNDPKAVSRYNAAGKIVDVLKKSKRSGEWLAIHNTSYHYLNFAAEPLEGKVKSGSKLVLKKTIYGTRMQSAISNTKIPPPTMTIPLRADCDYSDVPHLVSFQPTFTIASGISAPKIVTAMASNGFKSGNDDLRQDAIMEQTFEQVSDLLRDHRDTRQRKLGIRTYKVLPLASNSGIIEFVQNTMPLNDYLLPAHQRYFPRDFKPNQCRKFINDAQSKSRDQRIKAYRHVTDHFHPVMKYFFMEKFLNPDDWFSKRLAYTRSTAAISMLGHVLGLGDRHGHNILLDTETGEAVHIDLGVAFEQGRVLPIPESVPFRLTRDLVDGMGITKTEGVFRRSCEFTLAALREESYSIMTILDVLRYDPLYSWTLSPLRMKKMQDAQEAENGAVTSNEGRKKTNLNEPNEADRALTVVRKKLGKSLSVAATVNELIQQATDEKNLAVLYCGWAAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYX0</accession>
    <name>D4CYX0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025804.1">
        <property type="nucleotide sequence ID" value="XM_003025758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYX0"/>
    <dbReference type="GeneID" id="9582047"/>
    <dbReference type="KEGG" id="tve:TRV_00007"/>
    <dbReference type="HOGENOM" id="CLU_066247_10_0_1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="158" mass="16423" checksum="965E7B1CFC6D994C" modified="2010-05-18" version="1">MKTALPENAKIAKEAKECMQECVSEFISFITSEASEKCQGEKRKTVNGEDILFAMTSLGFENYAEALKIYLTKYRENRPSSSGYGSGGPVGGPAPVPAGMAGAAPAQQPPAGFAVPPPPEASNNLLTGSLDPNEQDGAAYGYPTMVGTAHNGAGGETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ58</accession>
    <name>D4CZ58_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025724.1">
        <property type="nucleotide sequence ID" value="XM_003025678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ58"/>
    <dbReference type="GeneID" id="9581967"/>
    <dbReference type="KEGG" id="tve:TRV_00095"/>
    <dbReference type="HOGENOM" id="CLU_012913_0_0_1"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="4">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="3">
        <location>
            <begin position="246"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="2">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="761" mass="85251" checksum="38A3F422F4455428" modified="2010-05-18" version="1">MEGLSWSRKLAVSPPNKTPKLTGDKITLPQTALEQILAAVRTIPSPTQENPLSVDLNSHSSIGSNDARQRELPHPLTFRLVNPINGRVVHSGIREFSADDNEVSLSPFLRESLGIEDHSFDVELDATQRDPLPTITVHAAQLPKGSYVRLRPLEAGYDVEDWKALLERQLRDNYTTLSVGEVLTVVANRSETMQFLIDEVQPEGNAICIVDTDLEVDIEPMDEDQARESLKRRLAKKTRAPENGAQSSIGGKITDGQEINGQVLPGDYVDYELEAWERSKRLILELDLDNDEVAVDIFASPFSARQRARPRNDQHVWGNFSTNFPKVIEIKPTNVELHDADCLYVSIHASHTQLRGQNGSTEPSHTQPIGFQLRVTTSAIPSAAAEADGLDQSARGSDETQCTNCRQWVPKATMILHENFCLRNNVVCPKCKKVFKKRSPEWENHWHCPHDDSSGTGDASEDRHNTVFHSAHTCRDCKYVCKNLPDLAQHRTTVCPEKLILCQFCHLVVPQKGESDPDVLDPEVVLSNLTPHELVDGGRTTDCHLCHKTVRLRDMNTHLRHHELDRVSRPSPQICLNVNCSRTINGPSYKQRDLTNDTLGLCKVCFGPLYVDVYDPEGKALRRRIERKYLSQMLTGCGKPWCRNKYCKTGRASCKIEPGTTLASKEILTMIKPLVESVSIGPTVVNTSPLYFCTDEATERRRELAEILAAEVVADAGSRTESYEIEWCIAAMESASGDPFKAREWLQNWAPKKGETYMNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZB4</accession>
    <name>D4CZB4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000009">
        <property type="protein sequence ID" value="EFE45056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025667.1">
        <property type="nucleotide sequence ID" value="XM_003025621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZB4"/>
    <dbReference type="GeneID" id="9581909"/>
    <dbReference type="KEGG" id="tve:TRV_00155"/>
    <dbReference type="HOGENOM" id="CLU_012062_21_1_1"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="379" mass="40452" checksum="B003EED7ED9B9E48" modified="2010-05-18" version="1">MSGARHWEQDKEATVYIGNLDERVTDKLVWELMLQAGRIVNVHLPKDRVTQTHQGYGFVEFNSEEDAEYASRIMNQVRLYGKPIRVNKASADKQKAVEVGAELFVGNLDPMVTEQVLYDTFSRFGSLISLPKVARDDSNLSKGYGFISFSNFEASDDAIANMNGQYLMNKEISVQYAYKKDGKGERHGDQAERMLAAQARKHNVQPQPQQPIPPQFAGGAPAAPGAAMNAGVQNVPSAVPVAAGMDAEQQRPPIDVGPAAPDFGAGRGMPPVMNGGYPNMNMAGPLPHHRAPHTPHTPHPPTHPPQPLVTPPAGLPARPPPSQAGYGGPHPGFPAQAPRFGQPPPAGFAPPPAGGPPGPGGPPGQLPPGFQQQGYGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZC3</accession>
    <name>D4CZC3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025642.1">
        <property type="nucleotide sequence ID" value="XM_003025596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZC3"/>
    <dbReference type="GeneID" id="9581881"/>
    <dbReference type="KEGG" id="tve:TRV_00165"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="4173034at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="63021" checksum="89F437CD71245A61" modified="2010-05-18" version="1">MLSATELFTEWPRLAIISVILLLIFRCIIYPVFLSPLSKVPAAHPLAPITGVWIKWHRWHGTSYKTIQTAFERCGPYIRLGPAEIATNCKEGFDSAYGIGKRNFDKASVYNYFAHFKTRALFSALEAKQHSHIRGRMAAVLTRAYVQSSHTRAIFKAVLLERLIPLLGQASQTGSGSVNILPLCYSYSIDFMSAFVFGLSGGHRLLEDAEDREKWLTLYYTIFMSNAPTLLGEFKWITRALTAFGIRLLPNDLSNLRKHSEDWTSQNVKLAESRLQSHYALGEPWAPGDLPVLYSALRSSIAREAGVEETFTPSDVQFRELASECLDQIALVLTYLLYQLSRHPAHQDELHRELLSIASPFHLDLDQEPSLYELPPARDLQRLPFLNAIIQEGLRLRNTPPGMDPRVTPKHCLSDVGPYKNLPPGIRVGAYIHLIHRSSEYFDDPLVWDPYRWLIKDCQGQSTGRKRRVFLAFSGGSRTCIGQHLAVECKPCPNPPVCHTIGPVIDHPPVIRNAVAAVYTNYRTMVFDESQYPGDRGFLSGDLKKDKLWIQFKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZE0</accession>
    <name>D4CZE0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase SirN-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025659.1">
        <property type="nucleotide sequence ID" value="XM_003025613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZE0"/>
    <dbReference type="GeneID" id="9581898"/>
    <dbReference type="KEGG" id="tve:TRV_00182"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="348" mass="39036" checksum="510CB213B2EF8B1F" modified="2010-05-18" version="1">MAIIISVRSSQDQATKPVYLGDSHQTKGGDSTMLPASTLLRMNMLESGEDRALAAASHFLPCALLANSFQTSHQLSGVAIRLANMGDHQDRQFEQDKSRYVIPGGSVERDRLRVQHEWIKGTAGGLIKAPLDLTAQGMKVLDSATADGFWIHDVRLVLPDDTEYVGFDIAVTEPFPPAWENSFDLINQRLLFAFFQRQEINQIVKRLVGCLKPGGWIQFFEYDHYTMVTDPQATTYLLFYKFAEQKVRNLHVKRDIMDALADAGCEHIQSECLEMVAGSAHVDREQGMRGRRVSRVLFHSFGSLVKLEDIGLSEDRRPSLAAELEKDMDMYKTGVAGNFIWAQKPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP6</accession>
    <name>D4CZP6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025526.1">
        <property type="nucleotide sequence ID" value="XM_003025480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP6"/>
    <dbReference type="GeneID" id="9581763"/>
    <dbReference type="KEGG" id="tve:TRV_00288"/>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28201" checksum="7151369B06DDF553" modified="2010-05-18" version="1">MVEKVYVTYNQVHKLCQASAGRILEEFRPNLMIAIGGGGYVPARMLRYGSNIILAETHGTHLFFFSFPISVSNWGCVQYRSFLKKKDSPNIPIQAIGLSLYEDLGRGDPEEVPGTKVTRTQWLDLSSLEMANLIGKNVLIVDEVDDTRTTLEYAVRELEKDVELAQKQLGRQGEKTTFSIFVLHNKDKPKKGQLPPEMLAENRYLAAVTSGDVWICYPWEATLVPPLPTPIHMSIPLCFAPGYWILTLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0C1</accession>
    <name>D4D0C1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RanBP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025336.1">
        <property type="nucleotide sequence ID" value="XM_003025290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582947"/>
    <dbReference type="KEGG" id="tve:TRV_00516"/>
    <dbReference type="HOGENOM" id="CLU_255442_0_0_1"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1319" mass="136562" checksum="1D58BC8A04924BFA" modified="2010-05-18" version="1">MIPTTHIRLQYHHQHPAHNEDGETTKLCIACSPLFVYAVLSSPLDEVSVCPRPVCLSCVAGWVYIFYLLLAPISNSLSLTSAKELPFHQLSQSSGSSPSSSSTSPRFPSSFTSRLNIFVILRTTPSNGFTFGQSQGFSRPATATGTSNNIPSASSSFDNNQSNTPGTFKLFGSQTTSAPPSFDFSSNNAQQVSNPFSNMSSNQNTGFQGFKGSMFNIPGASQPENKKPENQQNGTSGFFGQAPAQTSAPLFGATPTTSAPLFNSSAGPNMFGQSNNNNPPTNIFGSATMPSPTKSIGGGEAMQMSPDGPKSTAGQAMFNVSAPAPPIFKPTFSTPSTGSGSIFNLGGTPATTSAGTPAFSFKPTAGTPAPPASSGSSTLFGASKPEEPKAAPAVSSGNFMFGASASTPASTPLFGQQKPTEAPQATTTTAAPATTASTTKPPSIFGANPSFSAAPSGGSLFSHLAQPNNSAASASAANGTSSIFSNLGQPKPDTTPSPTKETGSLFGHLAQPKADAAPAPAKETGSIFSHLAQPKAETVTSPAKESPPLFSTPSASKPLFGAASTATAQPTTQPAFSFFGQTTKPAESPKPATATTGGQTPSIFASSSSNSIFQAQQQPTATQTENKNPTQSAPMFAASTNIPPVTQPKPMFTNSVNAGTSGASKPLSPTFGAAPVPAPAAPAEAPAPPKPKYVDASTETVFEASVTMVNFRPTEAEYPPNATPEVREQFLRLWRLSALNASFQEEIASVNCWSQDLDPIIGRYVMLRKLIGHPHPIVTQYIPATPGSKLPCKPLPPFSDYDAEYERERAQAAAKTSVSNADAAPSGPSGVSHKRKASDAGEEDSTSSDKTGKRTKFDANKEKDSDDKTDEAGEATPSKTLSLFANSFVAQKSRVSAADGDDEADAEADADGASSEESEESDEEEESTDAEKQEEKTTTPSVSPPSTSNGGGRSLFDRIQRDENGQPIRQVQADELREEAKSLANEANELASSVMGGSRTGSPFNAGSLTPLTGSTNDLDSTRSPSPIDPPKAKTSTPSIFANLAPSGSSNIFGASNSFTSTSSAGGSKPATTSNIFGAPPSSASSSAASGSAPATSIFAAPSPTSTPPPSNIFGAPPSTSAPAPTSVFATPSSAPTPTSNSSLAPPTTNIFGHLKPGNSSAQPGLSPFPLSAATSVDPSPAQSDTDATNDPSDEVEKHAQVDFTRSGPGEEDEDAVFECRSRAYQHINGQWEVKGLGVLRILKHRTNKKSRILLRADPSGSVVLNTNLMPEIDYKQNGTGVQFIVASESGFQHWLLRVKTAEGACELRNSMEQHKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0T2</accession>
    <name>D4D0T2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_00678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025152.1">
        <property type="nucleotide sequence ID" value="XM_003025106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0T2"/>
    <dbReference type="GeneID" id="9580645"/>
    <dbReference type="KEGG" id="tve:TRV_00678"/>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="569" mass="62210" checksum="98FAE7BE6DD6B27A" modified="2010-05-18" version="1">MLSSRRLSYALRRAGATGARITFANYPALRPAIAHFSSSTSRHLPETANAPTSKATKYTTDAYPKLKRNPNFAQLTGEHVQYFKELLGEGSAVVDGVTTDATDDIEPFNRDWMKKYRGHTKLVLRPKTTGEVSKILQYCNSQKLAVVPQGGNTGLVGGSVPVFDEIVVNLSRMNNIRSFDENSGVLAVDAGVILEVADNYLAERKHIFPLDLGAKGSCQIGGNVATNAGGLRLLRYGSLHGNVLGIEAVLPDGTIMEDMSLLRKNNTGYDLKQLFIGGEGTIGIITGVSIICPQRPKATNVAFFGLESFEHVRKAFLEAKGQLSEILSAFELMDGQSQKIVRKVTGLKHPLEGSYPFYCLVETSASNGEHDNAKLEAFLEHVMGESIVADGVLAQDESQAQALWRWREGVTESLSHLGGTYKYDVSIPLAELYQLVDDTRDRLSKAGLIGNDDSFPVHEVVGYGHMGDSNLHLNVAVRQYSKEVEKAIEPWVYEWIAKRNGSISAEHGLGIAKKEYIGYSKNDSMVKLMQQLKKLYDPVSHSSSSPLAVMAGCDVSTNIAIIERDNEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F4</accession>
    <name>D4D1F4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024899.1">
        <property type="nucleotide sequence ID" value="XM_003024853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F4"/>
    <dbReference type="GeneID" id="9580390"/>
    <dbReference type="KEGG" id="tve:TRV_00904"/>
    <dbReference type="HOGENOM" id="CLU_1074383_0_0_1"/>
    <dbReference type="OrthoDB" id="4174227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="265" mass="29996" checksum="237E7811CB3C04C6" modified="2010-05-18" version="1">MALDNSPYYGLDDRPQGQRRGNTQPLVISVDGACRGNGREHRDASAGVFVNQGSRFNESIPLNLDNPSNQKAEILAGIHGLNKAREMDGGPSRHVTIRSDSEYMVKGVNEWSRRWESNGYRAANGQPVVNRELFQQLNSARDSLERSGIKVDFQHVPREENRDADHWASQAFDNYHKSQDCGYYEFEEDCGPLGYQPETYTNDEEEFEGPHTSPEAFIEPTDAQGFHETTGDFYGASYEGSYGDSLDDCYDDCYDDDYYNDAYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1I6</accession>
    <name>D4D1I6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024862.1">
        <property type="nucleotide sequence ID" value="XM_003024816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1I6"/>
    <dbReference type="GeneID" id="9580389"/>
    <dbReference type="KEGG" id="tve:TRV_00937"/>
    <dbReference type="HOGENOM" id="CLU_2814268_0_0_1"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="67" mass="7373" checksum="26CAA492581777C1" modified="2010-05-18" version="1">MAPTNDDGQETKKQLKAMLWYTLGNLTREHADLFDTEVTPQFIAGLVEITWAQLGALNVSLIVQGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1K9</accession>
    <name>D4D1K9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein Obg</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024885.1">
        <property type="nucleotide sequence ID" value="XM_003024839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1K9"/>
    <dbReference type="GeneID" id="9580376"/>
    <dbReference type="KEGG" id="tve:TRV_00960"/>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="79"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="307"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61830" checksum="C6518CC0F42EA687" modified="2010-05-18" version="1">MAQLNGTLMPFLYPCLLLSPSANLAPRSALRAAKNLKHFRLSSSLHTSNRISPDDPYSQSIGSETNSRLNPAPSDYGRSIFQDRCSLTVHTGSGGSGCVAFLRLKYLEHGPANGGDGGTGGNILIQAVEGQTSLHKLARRGVIKAGRGKNGRGKSQGGVRGEDVLLQVPVGTVVREIERFDPVAEKERELKELTRELGSRTKALQAINSRRDQWVLYPGSQPSDYFATDFPELGPPRRPDLAAVQPAAPIYLDLSRHMDSPIVLAAGAVGGLGNPHFVSKSIGRPMFATKGEQGMRLELELELKLLADVGLVGLPNAGKSTLLRSITNSRTRVGNWAFTTLSPNIGTVVLDDYSQRKARLATPGRAPRPRFTIADIPGLIENAHLDKGLGLGFLRHVERAGILAFVVDLSAGDAVTALKGLWNELGAYQSMRDRELSLDTQSRLSPWTPVTDNLDEPRVNEWMGDEGHASSPPPPARDSSLQPLVYASHNIYSKPWFVIGTKADLPGTQENFTALKDYLDQVEKGTIEHPSKQEDAWRNRIFSIPISAINAQGVNIIPERIVQLMDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1N5</accession>
    <name>D4D1N5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024852.1">
        <property type="nucleotide sequence ID" value="XM_003024806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1N5"/>
    <dbReference type="GeneID" id="9580343"/>
    <dbReference type="KEGG" id="tve:TRV_01017"/>
    <dbReference type="HOGENOM" id="CLU_040048_0_1_1"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="411" mass="45944" checksum="6CEBC24E81F0BF23" modified="2010-05-18" version="1">MTDWTRETLLSHLSYGYSLKDLPPPQRIPSTRLAREATAISSSSIGALDTLPLELLHLILEQTDILTLLRFARTSLRAKSVLSSLHAYNFLLAHAPDALRQLALANLLAAHETRSIYTALLSTACSSCLQPSRATHFYLPSAQRICYSCRTLNPGLWLIPLSFARRCFRLGASSTAKLPLLHFRPDTTGTTTIITSGNRKHKHRRKSEPCVSLRDVRRLAEKVHGSMEEVYRLQTKGGMHASCLMEAYLMQFLRDAPCQPFTPFLLASTGWWEEISEYLARLLDDLGVVGRECVPLPWPDASMVVPSPASTSTSTSTSSSSSSAGDDVMEGYWCQGCSKLAMWYLQGRMEREVYSTLVPGVSDGFETIKALYALAMRVRSKDEFWRHVATCYAVQQNMPDIRLVLGQLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X8</accession>
    <name>D4D1X8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024731.1">
        <property type="nucleotide sequence ID" value="XM_003024685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X8"/>
    <dbReference type="GeneID" id="9580221"/>
    <dbReference type="KEGG" id="tve:TRV_01080"/>
    <dbReference type="HOGENOM" id="CLU_2098571_0_0_1"/>
    <dbReference type="OrthoDB" id="4174079at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="128" mass="13378" checksum="3E17CBCF464DBF54" modified="2010-05-18" version="1">MPMQHSLDMELITAAARYADENRSRLLLKLKQLISSQRNIHTNPEGVIGHARTDSSIYGSGNSGSPDVPTPPTGAATKTGAAVTEPAPPHQGTEAVVDDEPDTATANVNDSDIPNTAKAPATGTQNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2A0</accession>
    <name>D4D2A0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000065">
        <property type="protein sequence ID" value="EFE44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024634.1">
        <property type="nucleotide sequence ID" value="XM_003024588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2A0"/>
    <dbReference type="GeneID" id="9582809"/>
    <dbReference type="KEGG" id="tve:TRV_01203"/>
    <dbReference type="HOGENOM" id="CLU_3385066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="33" mass="3997" checksum="9621A155611B53A6" modified="2010-05-18" version="1">MLKGTEKEKKKKKREKEREREKKGREKCDGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2F1</accession>
    <name>D4D2F1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024544.1">
        <property type="nucleotide sequence ID" value="XM_003024498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2F1"/>
    <dbReference type="GeneID" id="9579767"/>
    <dbReference type="KEGG" id="tve:TRV_01256"/>
    <dbReference type="HOGENOM" id="CLU_095741_0_1_1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="173" mass="19153" checksum="B1547BAAB78F681F" modified="2010-05-18" version="1">MASDIPMSATELEAGGLYIMLSLRSHPPIPNDFHWAFYFHRGSDDGIKYHVRQQGNSGWMADHGSTAGVMKTFLLVGLFRISDVPPALRESIDGIMRTYDNRLNVPGVICTCRIWLLWILALLQRQVAGARILNCDDLQVLESEVKAWGNENALSASNNEQPRPIAASSLCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3E4</accession>
    <name>D4D3E4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024253.1">
        <property type="nucleotide sequence ID" value="XM_003024207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3E4"/>
    <dbReference type="GeneID" id="9579373"/>
    <dbReference type="KEGG" id="tve:TRV_01604"/>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="221"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131975" checksum="70E41F1074430A69" modified="2010-05-18" version="1">MVNHAQLLSDVLYSSPNDSSQQWLIYYISKPLVGSYEPGQIVQAIVPGTLDSVSLRHGSGLDASSTFPANYHRNEISSFGDLLSKFPLIAKQMKPGLDRLFREFGKELGKPLPPPPSESPVAPERPTDRSEVYSSQQNSTHSLPFGASEQYEDEEDVMRNALDTAVTAAIDIFRLVDKQQLSLLGATTDLTGPMVERLIERYVLEQVHDNLLFPRLCECRQSDDLDLDLRVRQMENIDVSQVGIPVEGGHEGREDLRRRIATAVEEFRKISDAKCPQDMLAILLKTVKIVTIDQASVAPDNQNEKPSVLTINADVLVSLLLLVVIRSHVRHLYARLLYMQRFIFVDDVESGESGYALSTFEGVLIYLQNDSAGLRKASSRNKRLWSATKHGKIPEMTAILQPELRESSPVTDENECENEQQDDSRSQENERQQPVPNGVPSNRHKLFFSESSCAIQDDVPETPRLAHVFPFQTWDQPTTTMERPKPRKKVSMDTRSMSESSITSFLSRSTTFGSIAGGIEGDTSVQSLTATKDPSGHSVPMMAVEACQPEALSYLLSLSEYYPRESILQDTNSEGTTLLSAAVQLAYTEIINILIEYILQGNESEVASYLAKADNRGRTVAHYLFNSPALLSRLGKSLPWTLRDRNGQTPLFALCRSYDHPDYNPMVNEALTLATQAQDDGNPLRLDDHVDAKGNTLLHIVSDPQILLRILRQCDGDPNYTNDRRFTPLMVASKYGRIDLVRTLFADPRVDVHLRESRGLTAIELAKDDEIRNRIDDLVLCSSPLPSSPDASNRTTSVVRSLFVEDFGIRFIIKSGAPSPSSPSPDPKAPRTTTYTVTTCRRSLNDFENLLRFLRVEHPASYLPEMPHFRSPFQIPSKPSRAVLHDIQERLDRLLKVLLAHPTFSTHELLWEFFLVPEIQTEMIDQRSARKATVLAESIMDDYEPASAEVIRSTQQILSHAEDAVQSVNEGTRNLICCGYLLQNASTDFADALFLCSSMFSSLQPPANILPHQYVRAFHRFVSSFNLSSTDSSPLLQFLAALTSSQNTTRAMLTSLSRPNNLILTLNSAQRSLSRARSAVASSSLPRKFNFSVLEESRQRSIREQESKIATLTTEIEEVRKEISWNKEVVVGELAGWSSWREQTGRKAIRDFVKTTLIREKERGKRMERCLRMIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3I4</accession>
    <name>D4D3I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">TRV_01644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024211.1">
        <property type="nucleotide sequence ID" value="XM_003024165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3I4"/>
    <dbReference type="GeneID" id="9579249"/>
    <dbReference type="KEGG" id="tve:TRV_01644"/>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="249" mass="27652" checksum="43A3EBEEC980DBBB" modified="2010-05-18" version="1">MADNKPEQSLQGENNDHLVQSDDPQHPANLIPEMCKNFYSLGWVTGTGGGTSIRRGEHIFIAPSGVQKELIKPNEIFVLSYPTPKYPPSARKYIRKPSALNPSACTPLFLAAFDRGAGCCIHTHSQWAVLVTLLVEREKGKSGCFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTESLEKAMEEYPDTYAVLVRRHGIYVWGDTPAKAKTQCESLDYLFQLAVQMHSLGLPWVVNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U1</accession>
    <name>D4D3U1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024084.1">
        <property type="nucleotide sequence ID" value="XM_003024038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3U1"/>
    <dbReference type="GeneID" id="9577072"/>
    <dbReference type="KEGG" id="tve:TRV_01753"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53920" checksum="B7DE184A4E5C9B62" modified="2010-05-18" version="1">MDEKVNPRPADADAAYNFLHEHNIDLSSVDEKALLRKIDWMIVPLMWACYNLQYVDKVLINFASIMGLLEDAHLDTNQFSYLGLAFYVSYLFFELPTGYLMQRLPTAKYLGANQSCLLLLDALFNDEPSLILITGMWYKKKEQPARMGFWYSGTGTATIIGALSAYGLLFYTGERFKPWQVMFLIFGLITIFTGILVVLFLPDNPMTSRLTEAEKVYAIERLRENQTGVENKHFKIKQFKEVFEDPQTYLLTLITTAGLVPNAAISQFQSLIIKAIGYTPKQTQLLSIPSGVVNMIAIVAATLLAARFGKRTLFMVAVLIPSLLGACMLAFLDNTHPAAKLAGNYLTHCNNAFLPLTYSIITANYAGHTKKVTMNAIILMAFCLGNILGPLTFKDEDAPEYVPAKLTIVVTMSITIVSIFVLRFYYKYENKRRDRKFEEGQVQPAADFLDITDRENLSFRVSYASSISSVLTLIKMILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Y0</accession>
    <name>D4D3Y0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024026.1">
        <property type="nucleotide sequence ID" value="XM_003023980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Y0"/>
    <dbReference type="GeneID" id="9582719"/>
    <dbReference type="KEGG" id="tve:TRV_01793"/>
    <dbReference type="HOGENOM" id="CLU_063075_0_0_1"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33486" checksum="72A15BF5FDFB21D8" modified="2010-05-18" version="1">MLSLPDFTNSRTKSIIHGFQAFIIFLAWAMTIAVFTQPGKTDGRTVYYFILCWVSIPGLIYLTAVPMWPRLRKFGNVFAFAFIDGLFTLLWFAAWIATATYVGTGVAQGEKDKDNDKNKDDKDKGKKSGCDVFAFGSPAKCRLSTGTTILAVLVFLIFIGTTLISLRSVMEYRRTGTMPYDGSDPTFAAHAQAAFSSNAAPHDFDDDDDRDAESRTGRYHGGPPSRQNDEDAYALLHNSEVDDLGPHGSHRPPPSYDPTASNVSSLPPRLSPIPPAGSSLSDYDTSYGGAYGGHRSEVSGDYSYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D444</accession>
    <name>D4D444_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lumazine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023996.1">
        <property type="nucleotide sequence ID" value="XM_003023950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D444"/>
    <dbReference type="GeneID" id="9582689"/>
    <dbReference type="KEGG" id="tve:TRV_01858"/>
    <dbReference type="HOGENOM" id="CLU_136595_1_0_1"/>
    <dbReference type="OrthoDB" id="3794857at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039437">
        <property type="entry name" value="FrzH/put_lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12893">
        <property type="entry name" value="Lumazine_bd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14791" checksum="613C9D460AA25747" modified="2010-05-18" version="1">MEKPATPKNTKPISTKEKEAVIKAAQYYVDGLKTGNVDHSRKGFHPNAGMYGWLDKDLKTVPIQELFDMIVERGCTPELIYHMDIIAITPSTAIVEVDSELENGGFRDHLAMVKVDGEWKTVAKLFHIYEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D447</accession>
    <name>EASF_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-dimethylallyltryptophan N-methyltransferase easF</fullName>
            <ecNumber evidence="1">2.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-dimethylallyltryptophan methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Ergot alkaloid synthesis protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">easF</name>
        <name type="ORF">TRV_01861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Microbiology" volume="158" first="1634" last="1644">
            <title>Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.</title>
            <authorList>
                <person name="Wallwey C."/>
                <person name="Heddergott C."/>
                <person name="Xie X."/>
                <person name="Brakhage A.A."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="22403186"/>
            <dbReference type="DOI" id="10.1099/mic.0.056796-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">4-dimethylallyltryptophan N-methyltransferase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:22403186). DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:22403186). The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (PubMed:22403186). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:22403186). Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae (PubMed:22403186). However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet (PubMed:22403186).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EFE43381" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43381.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023999.1">
        <property type="nucleotide sequence ID" value="XM_003023953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D447"/>
    <dbReference type="SMR" id="D4D447"/>
    <dbReference type="GeneID" id="9582692"/>
    <dbReference type="KEGG" id="tve:TRV_01861"/>
    <dbReference type="HOGENOM" id="CLU_049766_0_2_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000439140" description="4-dimethylallyltryptophan N-methyltransferase easF">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B6D5I7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22403186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="22403186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="22403186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="340" mass="38117" checksum="4354C2FD47B38A71" modified="2017-03-15" version="2">MGSINPPQILDIRRSKFEESIPKQVEAGLLSSPKTLPALLFYSTEGIQHWNRYSHASDFYPRHEEIQILKDKATDMAASIADGSVVVDLGSASLDKVIHLLEALEAAQKKVTYYALDLSFSELTSTLQAIPTDQFVHVQFSALHGTFDDGLQWLKETLVIRDQPHCLLLFGLTIGNFSRPNAAKFLHNIASHALVESPSQSSILLTLDSCKVPTKVIRAYTAEGVVPFALESLKYGNTLFQQDAGENVFDPEDWYFLSEWNYVLGRHEASLVPRSKDIKLGRPLDKIVVGKHEKVRFGCSYKYDSEERKELFGTAGLRDVKSWSKEGCDVAFYQLKCCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A9</accession>
    <name>D4D4A9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000102">
        <property type="protein sequence ID" value="EFE43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023936.1">
        <property type="nucleotide sequence ID" value="XM_003023890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A9"/>
    <dbReference type="GeneID" id="9582628"/>
    <dbReference type="KEGG" id="tve:TRV_01924"/>
    <dbReference type="HOGENOM" id="CLU_008721_2_2_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="172"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="36347" checksum="424077FC1D05AEB6" modified="2010-05-18" version="1">MAEELDFALEEALDGLINSTFGNAVEVIVSIVALSKNEIRIVQSSMLGSVLSNILLVLGCCFFFGGINYHEQSFNSTAASTMSSMMTVASASLIIPSTLYASLSSSKADSRENILFLSHGTAIILLIVYIMYLFFQLRSHPDLFESPNVEAGDTREEEEEEERILNPYAASILLLIITVLVSGCAEYLVGSIEPIVQSTGMSRTFIGLILIPIVGNAAEHVTAVVVACKNKMDLAIGVAIGSSLQIALFVTPFLVILGWIMDKDMTLHFQTFETVAFFISGLVVTILIQDGKSNYLEGGLCLGMYVIIAIGFYVYPDDAGDIGAVASQLASRFAVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4G1</accession>
    <name>D4D4G1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023926.1">
        <property type="nucleotide sequence ID" value="XM_003023880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4G1"/>
    <dbReference type="GeneID" id="9582619"/>
    <dbReference type="KEGG" id="tve:TRV_01977"/>
    <dbReference type="HOGENOM" id="CLU_051063_0_0_1"/>
    <dbReference type="OrthoDB" id="5386595at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="3">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="407" mass="47156" checksum="9778090265AFC6FD" modified="2010-05-18" version="1">MDSAERAARHKELIKSARQAYRRARQQSSEEIYDTPQYWRTTQTVLDTEDAVKDLVWQRRSETLSSEDHTFEQAKREYLKQKKEREERRRSAMRREERYQKREKVLNFPKTNNRATLRAAYVDLFLSIRGKTSRDKQNDFIASIKAAYGSKQLGNQTTYCNVLTGGWHVRQYFVAAHIFPLSYGQQAMDNIFGKDVHGEINTARNGLFLPSEFEQAFDAYQVVIVPYGPVTSEPREWQVILLDHSGLKDVPVCGMTFAQLHQKKLIFATDARPRARYFYFHFILAMISHYRAHKSVGVVKSELPDSMIPSLTRAWGSEGSYLADNVIHGFIEKVGHEIPAELQKNMQSQGFRGSFDTESEIDEIREATKGIDLRSDAEESDSDDDDDDFYDAEDWEDKETIDDVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4T8</accession>
    <name>D4D4T8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000112">
        <property type="protein sequence ID" value="EFE43144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023762.1">
        <property type="nucleotide sequence ID" value="XM_003023716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4T8"/>
    <dbReference type="GeneID" id="9582337"/>
    <dbReference type="KEGG" id="tve:TRV_02105"/>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="172" mass="19440" checksum="2C8E71FA37998692" modified="2010-05-18" version="1" fragment="single">SEVYNPHLNAYAPDSSITITITVDEVFDNDHRVVSQKGADKGRYTFSTADAGQHKLCFTADSHANSGWLSGASGPVKLTLDMAIGESNHLESEDKSKLDDLVERVRNLNGRLQDIRREQVFQREREAQFRDQSEATNSRVVRWALIQTAVLGVTCVWQFSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T7</accession>
    <name>D4D5T7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III RPC4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023358.1">
        <property type="nucleotide sequence ID" value="XM_003023312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T7"/>
    <dbReference type="GeneID" id="9583378"/>
    <dbReference type="KEGG" id="tve:TRV_02460"/>
    <dbReference type="HOGENOM" id="CLU_024330_0_0_1"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="585" mass="60875" checksum="FB7AC0A25F9FAB98" modified="2010-05-18" version="1">MPPNPPPNRPPAGRGQPSSSESSSATPGPSGTGGTGRGGSASARGRPVQRLQSLKKRTPGGSLVPLNADGSTPKPTLKFQPKVVTRKSKEEREALENLEAQRLRERISAANAARRPTRGGDRGRGRGRGRGGASGASGPLGEGTGPGRHGGAWKGKGGRSGKISGFYGVKNEAGADGEQIGGDISSDEGSDHGLRFSIDHINLESDSEGEALEAGAMTKGKASMGKSTPTGGSRGLRPVRVERHEHVERSVGIPAESSSSLSKSAELRKKAKEKAGAADDSLFVEDDQSESDVDGGDDDVVMGDIKETGPTSDGPQIKAEPTDDDATIDDSVPTAPSEEAVPKPRVKPKRVKDPRKKLQTEEERQEYDRYEEDIDYLKSTLGSISTTAGNAPDTSAAAEVGKKDEDDTEASAKPAPDERQGQLFLLQFPPMTPNLVPPTPEKNSAVGQGDEAVVETATPLPVAGTAPAAQGSATIKQEEGAVNPASTASTAPPLVTATNSTLPRGRVGKLNIHRSGKATIDWGGVSFELTKGSTVGFIQDAVILSDNMAGAPDGSASTRDKKLWAMSQVTGKFVVTPDWDKILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5W3</accession>
    <name>D4D5W3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023384.1">
        <property type="nucleotide sequence ID" value="XM_003023338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5W3"/>
    <dbReference type="GeneID" id="9583404"/>
    <dbReference type="KEGG" id="tve:TRV_02486"/>
    <dbReference type="HOGENOM" id="CLU_024466_1_0_1"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="536" mass="60678" checksum="9A6AF927AF864124" modified="2010-05-18" version="1">MDKCRETARKFVKQATSNSSLDIYTQAVTTCNVDLEGLWSDISEHKGDNNLPFLQEKSLHLLGVNFNLRMEEEQKNTIISKYREDRLKATIGLRVIALIAPVFLMNEAMHVEDILSNLAMFSSSSDPWTTVEGAQLATDLLQRYEIKLREEGKFGTIIEGMLRRKVKPAFSKTKTPAITSAGRKDMHPIPKPSFDPTLFDTGTKPWKFKEGYIVSVLNWIVRQYQNTDHSMIEQHFPLLIPAILSFIDDENIAYKAAGCYLIEVALRPLEQAGSDILRRTNLDSVFQDALSHCLLSIPTITPEKESVYLLSFAYPAIFTVIRTRFSAVTKYQGYSDKPLSTKSKADLEKDSQLRIESLSRLVRHHIISSYLHTSSPRPTEDTSISSYPHPSLSTLLLKQLAEAVTSLEIEAAKYLQDIVPLLSSTLTNPFGLAYVPLLIAASQCYQSVILNCWPRLSRWRGDILAGICACWLRLCDEKEDGVSSNDEQPDDRGHLRSILKRLVILLKAIEFDKVFDFEAELKELVDADDRLETLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D603</accession>
    <name>D4D603_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000130">
        <property type="protein sequence ID" value="EFE42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023330.1">
        <property type="nucleotide sequence ID" value="XM_003023284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D603"/>
    <dbReference type="GeneID" id="9583358"/>
    <dbReference type="KEGG" id="tve:TRV_02526"/>
    <dbReference type="HOGENOM" id="CLU_712852_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="43633" checksum="71821AFAF80B2F59" modified="2010-05-18" version="1" fragment="single">MNINTPENNVYNEDIILNEDFESLAPLFQSDASFAAGGNQVMGNISPISKPLDIMDSEVLSLTRASNDSVTKYSNLEKGEEGEDPKNCSSDMPPPQFSGMMWVELEKELDSSELNEYSEFEEAKAAFEAEKNPSLEAQIRFKKAKEKECLRISRAQLREALIEQEHNTQHGCINGNETGDVRISKAQEGENQKPGKENDFGLFYPEDNAAPAEELHRCTSPSNEESIPVFVWEHTQKSEELTKPKNRSRQNGAPKQARKTNNKAKVTKKGNNTRGRKSNGSTKFKKNSTNRGPTSLNFDSLFTSNIIENAKRNTKKKAIPKFTSGNKEEAMREIMASIPTDDDADMQCMSQHKKAIMGSIIKFTIPPRADHEGGWKHRDMMTSLFHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D618</accession>
    <name>D4D618_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023315.1">
        <property type="nucleotide sequence ID" value="XM_003023269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D618"/>
    <dbReference type="GeneID" id="9583334"/>
    <dbReference type="KEGG" id="tve:TRV_02541"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="319"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="74569" checksum="57554B3521B2C801" modified="2010-05-18" version="1">MPEDTRDSPQTVASGGTSTFDSGRRGTPDLRLLHYNDVYHVEASSSDPCGGAPRFQTLVNHYRSDPSFSGQPSILTFFSGDAFNPSLESTITKGQHMVPFLNHVGTDVACVGNHDLDFGIAQFRHLRSQCKFPWLLANVLDPALGEGEPLANCQKTCMLVSSNGIKVGVIGLGEREWLATINYLPPNLIYKSASETAKELVPTLREQGADIVIAVTHQREPNDNKLAEKIPPGLVDIILGGHDHYYSHSFINSTHVLRSGTDFKQLSYIEAWRKQSGSGWDFNITRRDITRDLPKHLGTVKLVDKLTSALKGKLHKPIGYTVTPLDGRFITVRTQESNLGNFVCDVMRCYHNTDCAIMAAGTIRGDQIYPPGILRVKDILNCFPFEDPVVVLRITGKALWLALENGVSELPALEGRFPQVSNIKFAFSMSKPPGSRILWVKLNNEDLRDDGLYTVSTRGYMARGKDGFASLLTRSEGGEAEEVVSEEDGLLLSTMLRQYFLSNKIIGKWNRLSPSLDRHWMYVHKKLKSEELTPPASSSTSTPTNILPETSFRYISKPGATQGASPVMTAAPVHQQPGAATLGRIGADTPLDSESDSHSESLFRPRNYVTSHALSPDDADHRELVARRVLRKWRKKLGVDPNRVKTVEQGGKDHLPPWTRAIAPVVDGRIIRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D642</accession>
    <name>D4D642_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023291.1">
        <property type="nucleotide sequence ID" value="XM_003023245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D642"/>
    <dbReference type="GeneID" id="9583311"/>
    <dbReference type="KEGG" id="tve:TRV_02565"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="515" mass="57037" checksum="F7B91732D8B8509E" modified="2010-05-18" version="1">MEKHEIEEPSSIEHLDDQVKTISPKIELEDPDAHLSPEERQKLDRALLWKLDLRLVPWLSLLYLVSFLDRTNVGNAKLEGLLKDLRLSDGQYAAALTIFFVSYSIFEPLTNILLKRLKPSLFIPVIMVVWGICMTTMGLTKNFSGFMAARWFLGFTEAGLFPGVGYFLSCWYKRTEFGIRMAIFFSAAAVAGSFGGLLAAAIAKMNGVGGKAGWAWIFILEGLGTIVIAIASFWMVQDFPDTATFLSEDDRKRVLLRLAKDQQASAGHEDFKMEYFWASIRDWKTYVSAFIYAGCVGPLYAFSLFLPTIIKELVSFSPPFTMCLPGHGYTSTTAQLLSVPPYAAGCLLTILIGLFSDRTKMRGLSNIGVSLIGIAGFSMLLGAKSPGVRYAGTFLGAMGIYPCIPNTISWASNNTEGVYKRGVSLGFIIGWGNLNGVISSNIYRHQDAPNFFPGHGIVLGYLIVFLFGGSVLQHILLRIENGKRIRGERNAWVEGLDEHGIEMLGDKRPDFVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D649</accession>
    <name>D4D649_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2-nitropropane dioxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000133">
        <property type="protein sequence ID" value="EFE42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023298.1">
        <property type="nucleotide sequence ID" value="XM_003023252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D649"/>
    <dbReference type="GeneID" id="9583318"/>
    <dbReference type="KEGG" id="tve:TRV_02572"/>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="354" mass="37577" checksum="E15327157DCC2B78" modified="2010-05-18" version="1">MPSLKKEYPWIQEPLIICPPMLPVATGELAAAVSAAGGIGFIGLGNNIDKLDAQLSLAAHHLQTTHAQTSLQTANAAILPVGVGFLNWGVKLEDALPSIKKHVPAAIWLFGAARETMTALYGGWIARVHAETNGLTKVWVQVGSVADALSVMDVSDAHRPDVLVLQGSDAGGHGLKKGAGIITLLPEVHDALAEKNIGIPLVGAGGIVDGRGVAAALCLGADGVAMGTRFLACKQTDIMKGYQDELIRASDGGQTTVRTTVYDRLRGYVDWPEEYDGRGMVNQSYVDEQAGMSDEENRRLYEVEKTKGDAGWGVKGRMTSYAGTGVGLVKAVMTAEEIVRQARDEARRVLKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D669</accession>
    <name>D4D669_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023258.1">
        <property type="nucleotide sequence ID" value="XM_003023212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D669"/>
    <dbReference type="GeneID" id="9583291"/>
    <dbReference type="KEGG" id="tve:TRV_02592"/>
    <dbReference type="HOGENOM" id="CLU_075221_0_0_1"/>
    <dbReference type="OrthoDB" id="4186697at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="31007" checksum="FCC253D783AC9E2E" modified="2010-05-18" version="1">MSRLIIRVNPDFLIDGGPETSDPIQAVVRPLSHPVFSSSKIRLFGPLGATIPLREFLVTPDEDVASTTVSPEQRMMQPWLPDPRCTTYYTPYLPRDLTEPQFKVMVQFHRFTRGEDVLPNQLSPRAIRYILSANNNLPDPYSRFNRRTRRWVYMGWTRAHFLAFFSIYRSVILSSTVDGSGILELRSLGEWLYAAPPEAMGCEEWERLIMEIGGLENILTDEERWDACHTIGVEAAGRADEVGDDDAVPVMRARKERKRGQKDRLAALLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D676</accession>
    <name>D4D676_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023265.1">
        <property type="nucleotide sequence ID" value="XM_003023219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D676"/>
    <dbReference type="GeneID" id="9583273"/>
    <dbReference type="KEGG" id="tve:TRV_02599"/>
    <dbReference type="HOGENOM" id="CLU_007548_1_0_1"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="532"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="780" mass="87195" checksum="590AB0AFF940F49E" modified="2010-05-18" version="1">MHGPLFPFVLARNRSCLDTQLREKIRKLARELEELEDEADRAPDAEAMARGAGLIKFKETDESRFLGPSSGIAITRFVMDMAKQNTGSKSIKEVVNENTAQQIKSVFDIESQKPTSKVYPMISSVAEPDLPPRELTNKLIDIFIAKAQYMVPILHEPTFRSDVDIVFNGSQDPCRNFQLRLVIAISMQRLSTQYAGLADSYYLAALPYFDGCLAKMDISTLQCCALMGLYSLLTPTRTAAYWVVGVAAKLCQDLGISDEETVTRGTNGEQLNCLEIDMRRRLFWIITSMEYGLAHSLGRPSSFCVSHDHINVNFFQTCDDRYITPNGILPGAQPIMKKCIAIHFFKMRLLQAEIRRKLYLCKRPAPLDDRDPWFTQMIDKMDRWVESCPKNDEGSGFSQMWFQGRRNTMIVFMYRPSPQIPEPSLYAAQRCYDASVFNVKIQHQQVATGTIDLTWIFTQSVFMALNTILWSLSYPEIRKEHPVGDVIGEIRLAMEILAISSERWPGVESALELYKSLISGCLKAYATDESYVVHSPPSNRPSPAPSSDFATPPPIAHSPNTAATAPSPVSQSKPTPNRLSSSPYEPTRSRASFEAARLHPGQIKFESTTPPPPSLATIATIPYDLAPPPQVTYANGNGSSIDPNTSSPAQTFSSPVTHSLARCDVSPTPTNNFDPSSFHNTFPSVVPGLHHWDPNYTTASTTASYLTYPSATIDPMSWLGTIGEQYSQFFNQPYQSNIFRDRRLSYEEHAELMDTLGHDLPDISQLAEETATFYTPSMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6G5</accession>
    <name>D4D6G5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023168.1">
        <property type="nucleotide sequence ID" value="XM_003023122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6G5"/>
    <dbReference type="GeneID" id="9583188"/>
    <dbReference type="KEGG" id="tve:TRV_02690"/>
    <dbReference type="HOGENOM" id="CLU_015848_0_0_1"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64574" checksum="CB05051B8EC9D9ED" modified="2010-05-18" version="1">MDRKEDTPGPEAPAACPSSSRLLVPPTRPPNSRRFSIRIRHSAASLTGEPIARTTSLNPEPVKRSDDDVVASRRRSSSEPQRPNFGNDGAAEYMPMTTVAEEGPSKYAQIEAGRGRWRSASASAMSSLRLAKAGQEGVGNVNDGKEYDSRVVNLLDVVGRFVNRQPTYNLTRPRSDSVESIISAVSEEEEETSTSDTEEPPRAKRTETITSNLSVSRFAVLPEGTTLDGWDPSDKWEINDHVRHMLHSRRSKFKRGMKGFWQYVQKREYTILILDYCKMELIYIFWLALGFLVTLYATLITLFGLAWVLFLIDNVLVALFAIVGDGLAPFRAIDTYHMIYIAYYHRLTWRLRRKQDLPKLKNPNDLPEAPLEDVIRSAAKENEIDIEMAARDVMTNDKEAEYSVLTPEQQKKLTHHSNKFSKSHTFYKPHETTTHHAFPVRMLIAVVILLDFHSIFQITLGACTWGIDYRVRPTALTTTILCLSISCNIASGIVIMIGDRMTRKKEVIEKMLRQQLTQEAIKKVEKKKKKKEKKKLEEKAAANCIHEEDEREDTIETSVDIEKHKPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6L2</accession>
    <name>D4D6L2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000143">
        <property type="protein sequence ID" value="EFE42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023118.1">
        <property type="nucleotide sequence ID" value="XM_003023072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6L2"/>
    <dbReference type="GeneID" id="9583138"/>
    <dbReference type="KEGG" id="tve:TRV_02739"/>
    <dbReference type="HOGENOM" id="CLU_1367116_0_0_1"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="200" mass="22024" checksum="9BB7B0FFA15B364F" modified="2010-05-18" version="1">MVLSRSPALRSLWAQSRRISAPRVPTTRAWQRVSRRGYADQAHGSHEAGSDMPWLLGSVAFTLPAAYYLYQSGPAGKSGHDAHPHVEHAVEKVKEAVSEPVKEEAKPEPAAEPKADPEETKTEEPKAEEPKAEEPKTEEAPKAESETEEKPKEEEKPAEAPAEKAEEEKPKEEKKEEPATAEDKTPNPRAPTKEPPTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6U4</accession>
    <name>D4D6U4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023000.1">
        <property type="nucleotide sequence ID" value="XM_003022954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6U4"/>
    <dbReference type="GeneID" id="9583020"/>
    <dbReference type="KEGG" id="tve:TRV_02821"/>
    <dbReference type="HOGENOM" id="CLU_1518847_0_0_1"/>
    <dbReference type="OrthoDB" id="4170853at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055620" description="DUF4105 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23709" checksum="55A0609A4F895B27" modified="2010-05-18" version="1">MKFSTIFSTLLAAASVAVNATPIARNEVDSSLISARETTPLSTPFSAELVKRETEDSDTFAALAQAYGGELEDDKYYVLTAKWPLRDEIDNETPAELQELQKKLGFYHIGFIVGKVSIKESGPKKHRKTKRDFDGQVYDTIKKENKDIKFRKTNWDTTKRRDIEFVKMTTKKKADAINNKAKDYEKDHPVYSVADNNCNTFVQALLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Z1</accession>
    <name>D4D6Z1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023047.1">
        <property type="nucleotide sequence ID" value="XM_003023001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Z1"/>
    <dbReference type="GeneID" id="9583067"/>
    <dbReference type="KEGG" id="tve:TRV_02869"/>
    <dbReference type="HOGENOM" id="CLU_454311_0_0_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="601" mass="64829" checksum="BD9D8B8B4FDEA145" modified="2010-05-18" version="1">MNALRTELTSCILAPWIAESHPDDRSPGNPPETDVAQPGGAVLARDDGVQQVAGRADGVLAGLGRQRLYHGGAHEPDPSCNPGVIGIIAPRVFASRVTLGEHGRPVLDLEGVDDKADALEGVSHPGGRGEEPGAGVSGLLQRQAMEHERSQQGSVDLRDVAVAAHFEDKDATGPEAVEDGLQDGDSGAGVSQDPMQRCVGHSINRQPNTSHHNTRIRRAVDDVGLSEQPAVEHPEGRWGRGSRQPRARSLDHGRRRVESQHGADGRDEPGRELAVAAADIEHSVLAARLQQLQHRVRQPGHEARRRFLNRPPRRQKPLSRTSEDQLSFSSPCISVSPLCVLFVSALSCVSVTARRRHQARRPRSACSHRAAKLAKGAARDRRSIEAAVDALSGREGGREKRAGDGRAAEEVLVEVKVKMPARDETDGRLEDGNLCHSLLLLCLLLQHPQCLMEPADGRSDDSDRYEQPQKNDDHGQKKNDGNEPFPALPELPGPPETLEMATLSIPNTPNTANTANTLNSPASPASPASRSSSPISVASGELGIVASRRPTTESVLTTASRQPSGPFAGLQRFWWAHISIRVPRKQNRDHFGTPNTSIYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>D4D738</accession>
    <name>D4D738_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_02917</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022930.1">
        <property type="nucleotide sequence ID" value="XM_003022884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576988"/>
    <dbReference type="KEGG" id="tve:TRV_02917"/>
    <dbReference type="HOGENOM" id="CLU_001037_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="58"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1892"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2152"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2329"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2353"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2369"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2397"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2406" mass="268240" checksum="9A3ECCD7D52A2063" modified="2010-05-18" version="1">MEESRILGEDLHALPERLLERLSQIPGYSWDQNVTPFQSSYDHWQFTGIKYSADSESISTHTAASSSSRSKASASSHNSPELEPRSFFPSQWRKAPSEAGSEITSPREEVERPWLPVIARVSGHVVRLEREFHILRTIVETSDPECKHTVRPIDIIHLAREPEDRGLLLVTIYEYVSPNYLRRLILGGPHSFQMDCSVPPSTNPDIEEVSLQAFFDFAIGACECLELLHYGLKTIHGEIRGDAFHFSEETRVVRLMNTGNGPRSFDNALGDGWAVLSKEIGVRNKLQFIAPEQTGRLPTEPDSRTDIYALGILLWIMLARKPAFEGKDLVEVVQNVLSKKLSPISTLRLDMPDACSAVIQKMTKKQINERYHTISAVKWDFQQISKLLGDGNSEALRDFQVAQRDVSSFFTLPSGMFGRKVEFDRIMSVINKASKRRQAATTPNKPSLYARSSASSISGDRLDAVEVDASSDSGSYAAPISAFRPNSISHASTSHGLMPSHDSMFSGDHGTTSGKSTLLSNRMKSPTDSRMSWEFIDRDSPSVAFDSGSLARRKAAHTKYRHGGRCEVITVSGPTGMGKSDLLQRLLPEIRKLGYVAVAKVDRQSKLPFDPFLKALASLLRQIFSERDISTEYHNSIRNSLQPIWPSLHQFLDLPYQLLFQDNVDYEPPVHQRSFQPLKGLKEGIEESFSVSAPEFTSLRHGQTSQDFIQGPSASGMNFVEIVIDVLRVMSLYEVICICIDNAHFVDDESAGLLLEIIKNKVRCVVILTGRTDDIVSPIMKSIFAGEGSSITNVVLEPLTEDDILEFVAATMHQTSNNSLVPLAAVVQEKSRGNPFYIRMILETCYRKNCIWYSWRDAAWEFDLDRVFSEFVVPGYGEGIGTNFVVKRLQEMPSAARSIVLWAALLGTTFSFSLVQKLLSGEFLFEVGGEEEDDVTCPAQTKWKQNSSDIVAGLQFLLQAYIIIPGETDDEFRFSSDHYAQAVASMRQCHNVEKMHFIITQTMMKYLPDNEATMHLKSRHIGLSAKLIKERVPIRTAYRDVLYRAGLSSYKSGAKAMALKHYQLCIFLLQDSPWAPDTPDAYYDETRELYIQVAEMHLALGQTEETLNALKPVFENARTAPCKARAWTLRSRVHSVSGDVCSALGDLFTCLEELGVKINRVATWEESDEAYRKIAKYLQTIDFDTLLTRPLSNDRALIAAGSVLNEAISICLWLDPMMYFHLTVEMMRLHLEYGAMAQVVYLYSQLSTIALSRFKDIELGLKLSDAALSILRITSDPAAIARGTTIHNFFINHMRDPVSAILPLLETSTEAAFFLGDRYYILLNVSSMVITRLVLGHDLGEIEDLCNDATEGIDDWVHDIRGGLGIVATRQAARALQGKTLASSPELALSDAYHDDQRLQAEVLERFPGKPHVLVTYRSIILIPLYVFGHYSRIVEMGTEMVGQLRGIFSSRLATQVYFYLSLATLSLHFEDPLRPDLEENLKTVERYKEEIDYMRDACDANYGMWSLLVKALLSELKRDFQGALVAFEEALDHAQIHNWPIEEALAYELQVDFLVRRGAKRAAQMMLQPAISVWNRIGASRKARQLTEKFEWLMRIGTVSRTNDVGCQTIDSLLGVQKSNVTESTSENRGLSSLESGHNQKWLEQNQGNDGPSDITGVGLDIIDLSTIIEFSHIMSSELEVNKLLTKMVGIILESCSGSELALVITEFESQGWCVAASGDNESDPIAYDNGLPFSEVEDKMAQQISNYTLRTREAVLVHNVLEDDRFTNLSESYASRHPHGRSIIVLPIIQAKKFLGVVHIEGKPNSFTQRNLVLLRLVCNQMGISLANAFLFQEVRKVSAANAAMVEAQKRALVQAREAEHKAKIAEVEANHNVKLKEDAAKAKSIFLANISHDLRTPMTGVIGLSELLKATKLDPKQDVYVESIRVCADTLLTLINDILDFSKLEAGKMKVSIVPINLRQTIAEVVRALRYTHREKGLNTIEDLDSIDPDLLVMGDPVRLHQIFMNLLSNSYKFTPAGSVTVRAIVEEDTPEKIRVTCKVADTGIGISEEQLVRLFRPFSQADSSTARSYGGSGLGLSICKAIIEDVLGGRIWLQSKEGEGTTVTFTLVFKKAGKDAVPKTPWTQEPGHKQPHAHRLRDISHIPRDDVRICIAEDNPINQKIAVSFVHHLGLSSEVYSDGEQAVEALRQRSRDGKPFHVVLMDVQMPVLDGCDATRRIREDPDPNVNEVLVIAMTASAIEGDREKCIDAGMNNYLAKPVRSDVLKGMLDRYLAPQTKALPKRSKSSAAASRLIELQATTPPKPPQPAPSIDELIAEEKRTKAAIDAATAAATKRREDTPNGDSMPEEYTEGSTEGNTEENTGEKSQPVEESRVEELNDDDGTPTPPGNDPSVDKTPTLNADTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7V1</accession>
    <name>D4D7V1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_03185</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022664.1">
        <property type="nucleotide sequence ID" value="XM_003022618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581323"/>
    <dbReference type="KEGG" id="tve:TRV_03185"/>
    <dbReference type="HOGENOM" id="CLU_000907_4_3_1"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="118"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="20">
        <location>
            <begin position="625"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="18">
        <location>
            <begin position="866"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1016"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1226"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1510" mass="173366" checksum="DB62774DBD3002A8" modified="2010-05-18" version="1">MEDNSDIDKATTNVPQTLKEENTNVPAADSTPETRSGTPTESETEDEKPNPANPSEKRRALNCKFKDLLSRRAEVITEDDVKAVIKATDDTQLSMTNIIAKQDYTSIIHDPREYQLELFEKAKEKNIIAVLETGSGKTLIAVLLLKHVIEQELTDRSLGLPPRISFFLNNIPQKIDKFCGAMQTDLWNKETWEGHFKRNMVIVCTAEVLHQCLLHSFIQIDQINLLIFDEAHHAKKEHPYARIIKDFYLKEPERKPKIFGMTASPVDAKVEVVGAAKTLEAMLDSQITTASNPALLRQSVTRPTEEIWEYDRLELPFETPLYSKLRQKFGDIKVLEKIFKFSRETSSSLGSWCSDWIWSYCLSEETLPKLEARSNRPLMKSIPDQSSCDTEAERIREAGAIIKEHEFGDPVANPELLSRKVLLLRDQLLRRFKENPDTRCIVFTAQRHTARILRDLFKKIGSQYIRPNLLVGVRSGGDKIGLDISFREQFLNVIAFRKVNESNEYLIPGLGTDFNLRFDLYSTLIQYIQSRGRARHMESTVCITYLEVSLVQTNIFTQFAHMVERNNLMHETAVEEEVLTRFCKSLPEDRLLKGTGDIDMMIEKDRQQKSYTIKSTGAKLTYPSSLAVLAHYASTLQYEKELSTQVSYIIHPKDGAFICETILPEKSPIRGCMGKSASRKLLAKQSAAFETCLLLRKNRLLDEYFISTYHKRLPVMRNARLAITSKKSNKYSMISKPAAWELSRGESPTVLYATVLSLSDCEKLQKSYHPIVLLTRVPMPDFPAFPLYLEHNKKCSSCSIRVEEGLKVIPPELELLTKFTFRVFEDVFHKIYEENSSLVSYLIAPAKLDGVTDIKKSNPVELIDWQMLQYIQENEELLWSPDMPNEFLENRFLVDKWDGRYRYFSIKVDPTRRPQDPVPENVARRRYMDNIMNYCLSLFKNSRARFMKRCNWDQPVLRSELIQLRRNFLDIDENQKSPPVDYYVCAEALKISAISVPLATQIFVFPAMIWRMESYLIALEACEKLQLKIPPELALEALTKDSENTEEHGMEQIRFQSGMGKNYERLEFLGDCFLKMATSISLFAMNPDNDEYDYHVKRMLLICNQNLFNNAIILEIFKFIRSRSFSRRAWYPEGLTLLKGKDKKEGPNGPEHALADKTIADVCEALIGASLLAGGPDHKFDMATKAVTVFVNSDDHRVEKWADYSRLYSLPNYQTASASASEIDVANQIQSKLGYCFKYPKLLRSAFMHPSYPSQWANVPCYQRLEFLGDSLLDMVCVNHLFERYPDKDPQWLTEHKMAMVSNKFLGSLAVSLNLHVHLIHISNTLQGQITSYTEELQAMKIKMEGNLEAWTYTNEPPKCLPDIVEAYLGAIFVDSNFNFDVVDDFFRKFIQHYFEDMSVYDTFANKHPITFLHTRLAVDFGCTFYALKADEIPCVDGTTVRALAAVCVHDDIVAEGVASSPRHAKLKASQNALQILEEMSAADFRAKYKCDCRERQEEHEEEEPETAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D864</accession>
    <name>D4D864_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000169">
        <property type="protein sequence ID" value="EFE41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022579.1">
        <property type="nucleotide sequence ID" value="XM_003022533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D864"/>
    <dbReference type="GeneID" id="9581235"/>
    <dbReference type="KEGG" id="tve:TRV_03300"/>
    <dbReference type="HOGENOM" id="CLU_438869_0_0_1"/>
    <dbReference type="OrthoDB" id="4199595at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="623" mass="70825" checksum="6F3A120AE8C5001B" modified="2010-05-18" version="1">MFRAKNIQASKPLGLQPRSSTSIAGRQTGRLSLQQYAQRSSQISRPSPSSQRGSGEQLFRPPANLNYLFNVDSNENDSNGSTSSEEDEDDDDVEAQDTKEPPEIVDLTGNSQETATPPNINDLSPIKSTNSLNQEPTKVEQLSQSSRRSTSSSQTRMGDDEAESWLQLRLAEEAAKKKRTIFAPLPPVSSQQRPHPPSPTPIRLTDAAWGSQSLRRKPNIWVSPSFLPVDRKHAACLERIDAIEAAFKRLEQIGLMNERSSIEKMEFENFKAKFDAKIPLTSTERRRLHDIQRNIERREYSWSVNKMALEKNIVKKRGYSAVNTSAEANVSETITSPRNPDEPNPSSSRRKRPTSHAAEQAELIQEDDKSGMEVETTDDEEDDDDPEDAQEDDAPEPVWAYHVFRTEIDPANPDPTPVYISSHLSRLRAESKMRDQISACYGNLKERTRMEFRATFEEDFTEQAVEFASGRMVIVRVEREIHEEPVKRKKRIKLERIPTKIYTIIEQIRTTPVGDITSEHPAKAEVQSTKYTEMSECFILRKDANAHANRLMLAHLTSHLDAAERFNSDVTGDIDMQARLYLHELDEGERLYDKKHVLPEVESGMRKEVSIRVLEHLVRGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8C0</accession>
    <name>D4D8C0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_03356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000173">
        <property type="protein sequence ID" value="EFE41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022514.1">
        <property type="nucleotide sequence ID" value="XM_003022468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8C0"/>
    <dbReference type="GeneID" id="9581090"/>
    <dbReference type="KEGG" id="tve:TRV_03356"/>
    <dbReference type="HOGENOM" id="CLU_010840_2_0_1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="6">
        <location>
            <begin position="233"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="585" mass="65396" checksum="AA0B505F11815847" modified="2010-05-18" version="1">MACRSRPRDSGGDSSSSTSPERAIDEDNDFFMLEANDSQSSIGVGNFRNLRVDSRRDQDMPLPPIYRLPPEILIAIFSKLSSPVDLLNCMKVSSCWSMNCVGILWHRPLCNTWDNLLKVAHAISDEESYFPYYDLVKRLNLTTLKSKVNDGTVFSFVKCKRIERLTLTGCKNVTDKGISDLVEGNRQLQALDVSDLESLTDHSLNVVAANCSRLQGLNITNCVNITDDSLVQLAQNCRQLKRLKLNGVAQLMDRSILAFANNCPSMLEIDLHGCRHITNASVTALLSTLRSLRELRLAHCIQISDEAFLRLPPNLVFDCLRILDLTACERVKDDAVEKIIDSAPRLRNLVLGKCKFITDRAVYAICRLGKNIHYIHLGHCSNITDQAVTQMVKSCNRIRYIDLACCNRLTDASVEQLATLPKLRRIGLVKCQAITDRSILALAKPRFPQHPLVSGLERVHLSYCVNLTVEGIHSLLNYCRRLTHLSLTGVHAFLRNDLTKFCRAAPDEFTPLQREVFCVFSGDGVGQLREYLNHSALRERSGTAVTMYDDDESPDEVDSQPSVSGLLNAAAINDGDDHPMAVQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K9</accession>
    <name>D4D8K9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022382.1">
        <property type="nucleotide sequence ID" value="XM_003022336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K9"/>
    <dbReference type="GeneID" id="9580929"/>
    <dbReference type="KEGG" id="tve:TRV_03446"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_3_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="161"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="537" mass="60769" checksum="50D2121C3D6E442A" modified="2010-05-18" version="1">MEEKVVKVGLVVEKMAAMLPEIPIAEPITILPEPEPEPEPDSGSDYTRSLETATETENSSEPEVDSDKKSDSETDIDPPAASNGIPTPTRPSPAPPSPHVSPHVERSNPMGHGAAQTVSSKDPKAAAQAASDMKNVVRRKLAGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPRERTGPSLDIIPKTVSVESISADIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRFDAYLDAENKVNRMNIVDNRVHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEIALFKQRILADIQHHSIQIFEGPRYELDDEETIAENKEIMSKVPFAVVGANSEVTSADGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNTLYENYRSDKLTQMGVTQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVQEKESKLKQSEEELFARHREMKEQLDRQRQELEEKKARLESGRPLEDKIKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V8</accession>
    <name>D4D8V8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022335.1">
        <property type="nucleotide sequence ID" value="XM_003022289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V8"/>
    <dbReference type="GeneID" id="9580882"/>
    <dbReference type="KEGG" id="tve:TRV_03546"/>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="352" mass="39638" checksum="595CDF63FEBAF781" modified="2010-05-18" version="1">MPSDLELLADMGFDPERAKIAVSKSGGCKSGRPMFTASAFKFLKILDDFGFFLKKKILNTDILSFHSVQGALEWLEANQDKSLEEIQEETAQKQSEAGASDEPPELKPGEEPKSLVCNECGKRFRSQGQAEFHASKTEHVDFSESTEEIAPLTEEEKKAKLEELRQRLAEKRQKMSEQDKKDQKRNEEIRRKSTKETQDMKEELQRKEQLKEAAKKKREKQEEIEAKARIKAKIEADKQARRLKAEKEKAEREGRVLEEQKAQPTPAAAPVASKPASAYTEARLRLMTPSGNVIKSFPVDTTLFEVAAALQQEGNQVNSFTQTFPKKVFTQEDFGATLEELGFVPSGSLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X5</accession>
    <name>D4D8X5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 7">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022352.1">
        <property type="nucleotide sequence ID" value="XM_003022306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X5"/>
    <dbReference type="GeneID" id="9580899"/>
    <dbReference type="KEGG" id="tve:TRV_03563"/>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="268" mass="31320" checksum="445F07953115F3F5" modified="2010-05-18" version="1">MGKLNFTALQVRRTAIAQQKAGKTPKLPCWIDIMERIPPSSVLVRNLPQQHPLTRERMKTLPGKTEPRSVIETRPTRRTKSKKPSRMFQPVKMEFEEDQLRREFYRDHPWELARPRVVLESDGKDHMRYNWDSLQQNRKRVDGESVVQRQLHLLNTVPDITKEQAYDIARREFYKLRLQEDVERRIAQEEARATGAYFGLDENTIGMELENQEYDRWKKWAETEIVLQQSSRAAFAGTEITEAEAESSMAGNDLSAPESKLLESIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B7</accession>
    <name>D4D9B7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_03708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022184.1">
        <property type="nucleotide sequence ID" value="XM_003022138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B7"/>
    <dbReference type="GeneID" id="9579055"/>
    <dbReference type="KEGG" id="tve:TRV_03708"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1199"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE41566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1225" mass="135833" checksum="49042B1792DA9FD1" modified="2010-05-18" version="1">MTKWNINIDALFTTIPAKSVNEAELIKVIPAANAGSAEICKLVKDNIGGTEVVSFLFQKRRFRYNLEKGCFTPLQYVLDTEPKPTLGYFQESRGLTSLAKVDDVQQHYGDNTFDIPVPTFVELFKEHAVAPFFVFQVFCVGLWLLDEYWYYSLFTLVMLVVFESTVVWQRQRTLTEFRGMSIKPYDVWVFRDNKWVEVSSEKLLPGDLVSINRTKDDSGVPCDILLVWGSAIVNEAMLSGESTPLLKDSIQLRPANDRIEPDGLDKNSFLYGGTKVLQITHPNAQAGQDSGYQPLNGASAAPDNGALGIVIRTGFETSQGSLVRTMIYSTEPVSANNVEAFMFILFLLIFAIAASWYVWVEGVAQDRKRSKLLLDCVLIITSVVPPELPMELSLAVNTSLAALSRFAIFCTEPFRIPYAGRVDIACFDKTGTLTGEDLVVDGIAGLTLGQTGVPTDKYGAHTTVAKVTDVHDNTTLVLATAHALVKLDEGEIVGDPMEKATLTSLGWTLGQNDTLTSKAGSAGRTGDNLLESVNIKRRFQFSSALKRQSTVAIVNILDKRLSKRSKATFVGVKGAPETISTMLVSTPPYYEETFKHFTRNGARVLALAYKFLSDTEIGQSRINNLKREEVESGLHFAGFLILQCPLKDDAIKAVRMLNESSHRVVMITGDNPLTAVHVAKKVEIIDREVLILDAPEHDTSGTKVVWRSVDDKFSVDVDPSKPIDPSILAEKDLCVTGYALEKFRDQPGLLDLIRYTWVYSRVSPKQKEEILLAMNEAGYTTLMCGDGTNDVGALKQAHIGVALLNGTQEDLNKISEHFRNTKMKEIYEKQVQLMQRFNQPAPPVPVHIAHLYPPGANNPHYETAMLREAQKKIAAGTAPSDVNGVPTITSPGAQALQQPDDTNLTPQQRKQKQASLAASSLADKLSASMMEGMDEDEPPTLKLGDASVAAPFTSKLANVIAIPNIIRQGRCTLVATIQMYKILALNCLISAYSLSVIYLDGIKFGDGQVTISGMLMSVCFFSISRAKAVEGLSKERPQPNIFNIYIMGSILGQFAIHIVTLIYISQYVYSIEPRKEKIDLEGEFEPSLLNSAIYLLQLIQQISTFSINYQGRPFRESIRENRAMYWGLVLTSGVALSCATEFIPELNTKLRLVPFEPGFRVRLTLTMILDYVGCWLVENILKTNFSDYKPKAIAVRRPDQLAAEEKRKQEEEEDKEKQKEAEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9C3</accession>
    <name>D4D9C3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022190.1">
        <property type="nucleotide sequence ID" value="XM_003022144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579061"/>
    <dbReference type="KEGG" id="tve:TRV_03714"/>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF32">
        <property type="entry name" value="DUF6606 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2009"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2351"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3028"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3113"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3031"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3142"/>
            <end position="3154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3169" mass="361311" checksum="DC110262B590B4D9" modified="2010-05-18" version="1">MKQHYPPSTCSKLEYVVNHIVLPPRLPGKEEVCEDDVRCELLAFLQAASITLKADSDAEINAVGRSIFNVLEICKATNLYGKLDKSSLLHQFQKIQPNTPIILHVKEQNAGLLIWKNERDGEETVIFESFEVSPVSEKVLSAEGPLQWDFPGETIVIPNTVFTQPSFQESLSNFLESASTESIKRFAAGVLKGGSVAFENRDTTDPALITQMLMTLLEANGSRIFPPLLRKRVRDEVSWAPGGGKPWRRLPFWLVLRVGIERHLHLQLGATKGRAYYKFLLCLMFSAILGSGTDSLSPDLISLLTAKLARRLAKLEVHREKALHNDRVTYNRLFDRFELFFQTSISNARNHVADIWNTFKRSIRRKIPRFPLHADENSQYLSLTNSEKEIENVLSQYRIDRSRTANNPSAKDFIPKRSNAFKKFANTYNSLSQRERVSNEALKFPHSSAEETCIELAVMIWNYYNEAEPAYNGNPEQKSIMILHMMVLWVELDKCATKIYPLLLDYHPGISSSLLDVLQLSSLKDSIRLNTVQEYIETRCTRSLSRRTIFDDPTEGCFAERYFDLSEDSLRLQNLRSKIESQAQKNYDRKVQEWQQKSEIFEALQKKITLSSCTYITNRHGGVDHDKNCEKCENQHRANRMTIQIHEHPLPENPVHARAVVFELQCPEAFKSYRNATWLLFGIVACPHEQPPAYPRLLISEYRELSKFFTGSSEGIVLASTTKSLLSTHYRGVYFPVRLEDICFDNNLRVRYYDTTHNIFPNRQSHVSSVSHHLQMPNLTNSPFSSIAPPGSLSGSSSYEILASQSSCPPGLNAHEFMAYKSLFSGVVRRWPTILIELGSSNLNFSTKGPCTLICQLAIQAGPRDTNDVFRVVHKIFRDETFCNRLIKLLEERLTGIAMNWRETDCMEMLITLILRLCALSPLRTIDKAISLLKKIQETLLKWIRLLRKEICAACEPDMIENYSDFAFTVALLLRRTFAVYPENTPRYTGNMAESDIRCFIEASISLQDNIPPDLKSLSHFQWRALVRDLKMVYRMRPILLQSLKNHPGSLGAVLTDIWAQNTLLLGQMSSLQLLSGDEWAQLVINPTNQTKRQVVHFHFLEGHLLVDGEPLATLPANYRNAMVLDRLFGNQRLQVYPSSLHGMSYVLPFEVKKQRIHIGFRDGKPFVRAESRRTIYEFLPYEIFGDRRNFDLPGSLVENCIHWLDLKSGTIKIRRKPDIWYGKDSYWEVDFYNRKARRRTVTLIDPHSQLFRLIANVFDGFEHPGYITIYQPASKNSSVELRRLELDFIVTKSGQLRCKQLNALIDMNQDAGTWYGLKSKLVLRDVIDNEQRSIIVPMGPLQCTRNGIHVSVFAENLGTYGRFFINTSLGRLDCPVEPWTLYAKAQFHAYTSFVLPDELTGRTGTEEAVHCLKSSYSQPWTTLNPGPLGTLQTVALLAPTRIYYPPGSKTVQHTIWNENLTPWIQHEIFSSLVEKILETERTLRQFGNKEIDQPAVRPASDDFLMIRAYRRRNIYQRPNAGFDDLPIVKDEVYNPRDRFQAVRRRSNVFEISSLVKNWSTNTGSHADLIRRMESWPTIGGYSTVFDKVLLSDILDIQFDVSWGSLVNFCRDSEEKNKYHLMMTMALMSFSNSADMEIIRTLLLFATIPSLKSLTPPNWVHYKHFRYNQQPSVVYLRRLINNCCVPYTGDERGVLPLNIKTRKRFEAAEREHEKRVEANAIAFSEYIFAQWPCLEPKIQGMPDFPLLNVHLALKVILPDWSRLFQNSELSNYLAKVQATLVSEIFPTGFRGQDIPTLASNLLRKACTLYTHESHHTKNTITTYKASQEEGIRRVFTGSDNPPSLLSQSSGFTQILELEEIIGKIKDSPSLVRHQYGHDLMTSLEALRSIKIVNDIPADKEFDESTIYTNIGSATQKVESHVEHLRSVLNKDDSRFRWLHPAGLWPCMTMVTLLEHLRSTFKGEFGAGMKENLIALAVEIIHRQRFIRIKGAYLRRQDRVLEEEKNCMPHSNWDPSLHPDWLLLQIDADICIRPNQVEVAHATISPSSQANAVLQMNMGQGKTSCIIPMVAAVLSDTTKLLRVVVPKALLLQTSQVLQGKLGGLVGREIRHIPFSRRTPTSTDMINSYLKLHKDIMSSAGIIVALPEHMMSFQLSGLQRLVDNKLPEARRMIKIHGWMQTVCRDVLDECDFTLAPRTQLIYPSGTQSTVDGHPHRWQTAEKLLELVSGHIWGLWQRYPGSIEVIQRPKGGFPIVYFLRKDAEEALISHVVRDIIDGRTSVIPVQGCCRSEIMDIKAFISEVSISPKTVKRVSSLFPDNSAARQNIYLLRGLLVHRILLLTLKKRWNVQYGLHPLRDPIAVPFIAKGVPSEQAEWGHPDVAILFTCLAFYLGGLELSQVRQCLDDLMKSSDPSTIYEQWITNSEKLPKILQDWNSINTEDESQVYQLWSHLRYQMPLINYFLNQFVFPKHAKQFKVKLQASGWDIPLSSPHANLGTMTTGFSGTNDNRTILPLTIKQQDLSSLVHTNAEVLTFVLRARNYVVAKDSEGKRLTEEGLLALLKRMEIRILIDAGAQILEMDNLSLAKVWLKVDHSAPAAMYFDPENKPYIIYRNGYRVPLLASPYAENLADCLVYLDEAHTRGTDLKIPADAVGALTLGLGQTKDHTVQAAMRLRQLGTTQSITFFAPPEVHHSILDSRKLPSSAPVTAADVIYWLLVQTCIGIEQIQPLYFSQGMDFCRRRQAAVDTPKYLTDQAQRQQYCKALQQEEMQTLQELFRPIAKVKSKATVAAYAPHIATHVKDLEHRKKGFQDFGDAVHSSALQEVEQEREVAYEVEAIREVQKAPRFKALNFPGIHEDIELFCRTGTLTSYSSAYQQAFIALRNTGIGQKHGINSCATSSKLFLSKEFFKTVRLPVGEYNDNYIRQVNWILWNPTTEAALVVIPEEAELLIPLHQNAKHLHTRLLTYAAPVTRGMLHFSNLDFYSMPPLPENWKAPLWLTVELGILAGRVYFDYSEYESICHYLGLTSSPVETAPSHEESEVESKEPTQDMGGESVIHTNNPTFTPKPLSFLQEWLALRRKGQDFSNTPMGYICQGKILNERSPFFSSGRDIRVNVPKLKATDGRSDGGNVESPGASDYESEDIEDQRRESTGKREIFTDDSSESDYHDNAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9I3</accession>
    <name>D4D9I3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000194">
        <property type="protein sequence ID" value="EFE41491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022109.1">
        <property type="nucleotide sequence ID" value="XM_003022063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9I3"/>
    <dbReference type="GeneID" id="9578993"/>
    <dbReference type="KEGG" id="tve:TRV_03776"/>
    <dbReference type="HOGENOM" id="CLU_007407_0_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="760" mass="81737" checksum="83515A19ED4F1F20" modified="2010-05-18" version="1">MASYSTGAGGQHAHQQPGDGSQARSQDIREALSDSQCCDLIDLILNTADCMEDLLCPRAEPEMKGSLSRGNALDSGKEDVDLLGNETDQPQRPKRPVRSATTVAAIKAEAEASRHFGSWRDAVLARVRQALQDPNGRAPLKPRQAQQSLIDLDEGGLGQQDCALQELPSETKDLIVNSLLLILLSLEHYNAHSRVLLVRVALQLGLQVADVSEHEMKVAHVLLDSVKEMNHAEEELKRRADQSKISRRWKVGLASVAGAALIGVTGGLAAPLVAAGVGTILGGLGLGATVAAGYLGAVAGSSIIIGGLFGAYGAKMSGRMMDRYAREVEDFAFLPLGSTPKPASEPTEARPPSSDNRLRVTIGISGWLTEGKDVVEPWRVLGPDSDVFALRWELQALLRLGSSLTTFVRNTAWTVAGRTVLSKTALAPIVGAVMLPVTISKISYILDNPFNVAKVRADKAGQILAEALINKAQGERSVTLIGYSLGARVIFSCLIALAKRRAFGLVESAILIGSPTPSTTSHWRLMRSVVSGRLVNVYSENDGILQFLYRANSMQLDIAGLEAISDIQGVENYDVTGIVSGHLQYQFSIGKILQRIGFDHLDEREIQRQEHKLEINEEEMKNLEEERIATARAAQTSGTGTKKAAIKVQERQPRTGPSVVVSSGTLSGAATATATTGIEATAGTAVDGAEGDHTDDTDDEAPTGIMMVDNDDIELDDSSDTNECPYPDIEPEQLERDIEEMTRQRLLNARMDGIQLEDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9M4</accession>
    <name>D4D9M4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000196">
        <property type="protein sequence ID" value="EFE41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022076.1">
        <property type="nucleotide sequence ID" value="XM_003022030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9M4"/>
    <dbReference type="GeneID" id="9578960"/>
    <dbReference type="KEGG" id="tve:TRV_03817"/>
    <dbReference type="HOGENOM" id="CLU_2225113_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="106" mass="12017" checksum="A54990920D3A1AF9" modified="2010-05-18" version="1">MIVDATWLFHPHLRLSVRICVDNELSMECRLDTEPGISMASTAPRLETAASREATNRAPSKEPTQIRNRKAKKKAETRRSKEQEAKNLASSYLPIRISKSQPEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Q6</accession>
    <name>D4D9Q6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022032.1">
        <property type="nucleotide sequence ID" value="XM_003021986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Q6"/>
    <dbReference type="GeneID" id="9578916"/>
    <dbReference type="KEGG" id="tve:TRV_03849"/>
    <dbReference type="HOGENOM" id="CLU_067359_1_0_1"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18565" checksum="159D95F471105FDE" modified="2010-05-18" version="1">MVVFVVGFAIESSQAHDRKFVSKSCNANIKTEISIYNRPYDAGSKAHPFPYALVVGIERYPSKITRRMGTKKVEKRSKVKPFIKTVNYNHLMPTRYTLELEGLKGTVTNDTFKEVSQREEAKKTIKKALEERYTSGKNRWFFTPLSMFLESYGPHREQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA19</accession>
    <name>D4DA19_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021933.1">
        <property type="nucleotide sequence ID" value="XM_003021887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA19"/>
    <dbReference type="GeneID" id="9578816"/>
    <dbReference type="KEGG" id="tve:TRV_03963"/>
    <dbReference type="HOGENOM" id="CLU_035168_0_0_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000108">
        <property type="entry name" value="Octanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="293" mass="31892" checksum="92590D52299960D1" modified="2010-05-18" version="1">MRLAHLHIPNIIPFRQASLLQQILVSRLLTHKRKQSESPALFPPTSAPDPTILTFTPRPVYTTGRRDLPASCSPNDESSNTFATKASDLSLPTPLEPIRNILTPTSSPTNAAQHLAEYYPTLRGGQTTYHGPGQLVIYTILDLRALRIGPRCHIRLLENSVLDVLKGFGVKGGTTTEDPGVWVKPDVGNSGMPRKVAAVGVHLRRFVSSYGVGFCITEEPLWYLRQIVACGLEGKESTSLEGVGVNVGDVTMEEVGTRFVQAFVDRVNSGGPSGGQGPRLDEVYRIQEEDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA27</accession>
    <name>D4DA27_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021941.1">
        <property type="nucleotide sequence ID" value="XM_003021895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA27"/>
    <dbReference type="GeneID" id="9578824"/>
    <dbReference type="KEGG" id="tve:TRV_03971"/>
    <dbReference type="HOGENOM" id="CLU_053393_0_0_1"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="286"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="43362" checksum="EEBBBB51B8F294A7" modified="2010-05-18" version="1">MLASRLLRSGTSPSLLRPFSTSCTRLRAPSIRDITPDNASSFNTRQKEFRDNLEAARKRKAEQDSQSLDASAPVSPSSSSSSSSSAQAPPTAPDASNASGPSTVVDAASSLDRQALGSLSTHRIVGERQQAENNSTPGRGRLSSLIYGTKEGQQLDKDIERSFSEVLARGKYVHSIVFHEVKPDKVDEYVGLVGEWYPKMAGMEQNRVNLVGSWRTQVGDNDTFVHIWEYQRYTGYHASLHEIGQQPGFVEFDRKLKSLIKSKKTSLMQEFSFWPTTPPRRLGGVFELRSYTLHPGNLLEWESHWRRGLAARRQIMEGVGAWFVQIGDLNTVHHLWQFADLEERKKRREQSWELEGWADTVHKTVPLIQTMKSRILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA75</accession>
    <name>D4DA75_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-actinin, sarcomeric (F-actin cross linking protein)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021844.1">
        <property type="nucleotide sequence ID" value="XM_003021798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA75"/>
    <dbReference type="GeneID" id="9578726"/>
    <dbReference type="KEGG" id="tve:TRV_04021"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="67014" checksum="CC6FFAEE1993D304" modified="2010-05-18" version="1">MTNIGAEDIVDGNRKIILGLIWTLILRFTISDINEEGMTAKEGLLLWCQRKTACYPGVEVRDFSSSWNDGLAFCALLDIHRPDLIDFDSLDKTEHRKNMQLAFDIAAEEIGIPDLLDVEDVCDVAKPDERSLMTYIAYWFHAFSQLEKVENAGRRVEKFVQNMQGAWEMQNSFERRMRALLKNIAAQQEKWLNSTFEGTYADAKEQASEFAAYKKNQKREWVAEKSDLAALLGNIKTKLSTYRLRAYDPPPELRLEVLDEEWASLTTYEHKRSQLINETIRDIKNALRRSFADKANDFALTLNTLSLAISGLEGDVEDQLTHVRRLSDNLPPLDAFLETIEDLDEQCAEANIEENDFTTYTFEELSYELSLVKSSVAKKLAFLENQMVARNMTNLTPIQLEEFESVFRHFDRDSTNTLHEIEFSAALASLGLVYDEDEMHEVFVETCGPNRLERNAGVSFEQFIRFMVSVTEDQHTAEQVLQSFKEVADGKVISTIEFCPFSWELFYSQLPPYNLHPYVTELDLRHSLIPDELIENLVESMPKHTGPDLLEDRDVAKYDYMTFMEHMMNNGGRGNDVGTNHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAH7</accession>
    <name>D4DAH7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021793.1">
        <property type="nucleotide sequence ID" value="XM_003021747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAH7"/>
    <dbReference type="GeneID" id="9578673"/>
    <dbReference type="KEGG" id="tve:TRV_04124"/>
    <dbReference type="HOGENOM" id="CLU_2308115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="100" mass="11155" checksum="101BE13809DCCD65" modified="2010-05-18" version="1">MVWEACSGQELSVRLPIPAASWSGGRPPSSAGFPSPYLVFRGLRSLSSLSSSFFIVFVLLLLLLAEKLGEKQKKKKKKKQEEKKEEGREEKGQKKTTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAP4</accession>
    <name>D4DAP4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021681.1">
        <property type="nucleotide sequence ID" value="XM_003021635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAP4"/>
    <dbReference type="GeneID" id="9576764"/>
    <dbReference type="KEGG" id="tve:TRV_04192"/>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46203" checksum="DB8856BF582B6BC9" modified="2010-05-18" version="1">MHQYARYFERYRQLAQTRPLNELLPPETLAQFRAEIENAAGNVPPGSRSEAEIERDIRLRADGHFLEIFSRTQTETTKRWTYESEIKRPYFHVTELDEGQLSNWRRYLDFEEAEGSFARAQFLYERCLVTCAHYDEFWMRYAAWMSGQEGKEEEVRIIYQKASSLYVPISRPAIRLHYAYFEEMASRVDIAKDIHNAVLLAMPGHIETIISFANLSRRHGGLDAAIEIYKTQLDSAECDIQTKAALVAEWAKLLWRVKGTADEARQVFRKNQHWYPDSRPFWTSYLMFELEQPTSAETEPAQYERIKQVIDDIRNKSSLPAEAAKELLQLYMTYLLERGSSEAAKEYITLNREVNGPPSVQSIMKSSLSKETQDKLVIGQQSPNSMFRPDVSVPTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV3</accession>
    <name>D4DAV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021621.1">
        <property type="nucleotide sequence ID" value="XM_003021575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV3"/>
    <dbReference type="GeneID" id="9578599"/>
    <dbReference type="KEGG" id="tve:TRV_04251"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="470" mass="51585" checksum="E49516EF2D895230" modified="2010-05-18" version="1" fragment="single">CSTLAKELPKNVFTSDSKAWDTHNKDFWSLTSILDPSCVFLPETSEHVSKAVQILAENDCKFSIKGAGHSAIPGAANIHDGVMIAMAWINSTDVQDDYIRVGAGAHLGEVYKALDPHHKAAVVGRFSEVGLGMVVGAGISFFSNSKGLAIDNVVNFEVVVASGEVINANATSNPDLFWALKGGNNNFGVVTQYSLATIDTAGMLHGGVITYPESSFDEVADVIYDYHTHQAVDDVRTHSLPQYAYDGATNETTAGILVAYNDAVDELPEIMQPWLKVNYTTNTLGKKTYSELAEELNGRFAGDGFVQEQRVFTVYADAQFYKDVWFKFRQWFQDYRDIPGFQGSHGNMPITPRQAEEGVKKGGNALGLQEGPQDKTLGIIYFGVTFKDPKYADKVLPAHKKFVESMRKLAEDRGVLHPYIMLTFSGYDQPAIASYGEKNVAKLHEVSAMYDPKGVFQRLVPGGQKLPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAX9</accession>
    <name>D4DAX9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000217">
        <property type="protein sequence ID" value="EFE40986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021604.1">
        <property type="nucleotide sequence ID" value="XM_003021558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAX9"/>
    <dbReference type="GeneID" id="9578565"/>
    <dbReference type="KEGG" id="tve:TRV_04277"/>
    <dbReference type="HOGENOM" id="CLU_021214_1_0_1"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="490" mass="54394" checksum="FC87D16F1AC433FA" modified="2010-05-18" version="1">MRLSISTASTHPPFSYKSVLSPKEESKSNSSNLILYLPPGPLFDRSQYTKGHGSTGTTSTSNGSSAAKQNTFTLLPEENLAITTLCTTVVVKYRLGRIQAAGIRKTYRYPTPVHDTLAGLDWAKNEFQPDNVFVFGRHIGGSLALMLALTEARGLKGVAAEEPICDWVGLDDYCITDIEKAGPDTEKPEVEQDKESARKRGRKKKEPLPTPADLVPLLDARRRLFPTPEKYFDSFASPTLFLRTSGKYIPLVFPTYLTGPEYPTPVLKRQPKTEADALYMTDLLASSPSENSTSTDRSENIPDKSLTSLIKPVRKRKVLSRWPPSGLDYGLEAYEAQNRWVKREETALPDVRIFVRDEDLYAKELENQDKATSLDDRINTLMEALKLDGYSNGQEMGRNSPSKGKAHGNTVLARQGKEMVSLMRSACFWDRKKGAAERCVKLVPILPPDADQISGSSGNEAADSTPYEVRPVEVQAGHRFMEILQGSKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA7</accession>
    <name>D4DBA7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021559.1">
        <property type="nucleotide sequence ID" value="XM_003021513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA7"/>
    <dbReference type="GeneID" id="9578520"/>
    <dbReference type="KEGG" id="tve:TRV_04406"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_2_1"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34111" checksum="5C2C21E927FC9A15" modified="2010-05-18" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIHLDEEFDLFAHSDPDSVRRVVDLCAAPGSWSQVLSRVLIRGESFGRRQYELDRGGTGGVAEEVRPRRDVKIVSVDLQPMAPLEGITTLQADITHPSTVPLLLNALNDEGEEEKVDLVLSDGAPDVTGLHDLDIYVQSQLLYAALNLAMGIIRPGGTFVAKIFRGRDVDVLYAQLKSVFGRVVVAKPRSSRASSLEAFVVCRDYKGSPQRAITGTTSTERYMARFVACGDVSGWDADASYELPEDHVSLDPVQKPTAPPYKRALELRRAKGGAFGKTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC3</accession>
    <name>D4DBC3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021449.1">
        <property type="nucleotide sequence ID" value="XM_003021403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC3"/>
    <dbReference type="GeneID" id="9578429"/>
    <dbReference type="KEGG" id="tve:TRV_04422"/>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03188">
        <property type="entry name" value="GST_C_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03057">
        <property type="entry name" value="GST_N_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26059" checksum="D9E89AE955620F03" modified="2010-05-18" version="1" fragment="single">LTTSIKSSSSVSILSFTHDTIMASTTPSIKLWYAPGACSLAPHIILKETGANFELVKVSFDSINSDEFKAVNPKLRIPTLSINEDIITENPAVMMAISNLVPEKHLFGKTPLDTVRVIEWANYISGTLHGQAFAGLWRPQRFTADPEDHHKLQAMGMTTIKESFRYIDDKLKGVHAVGDSFTIVDAYLLTMYRWGQKIGLSMESDYPKLTALVAEASKRRATVAAMEAEGLPPIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG4</accession>
    <name>D4DBG4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021390.1">
        <property type="nucleotide sequence ID" value="XM_003021344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG4"/>
    <dbReference type="GeneID" id="9578269"/>
    <dbReference type="KEGG" id="tve:TRV_04464"/>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15295" checksum="8C9D687E6E6B9105" modified="2010-05-18" version="1">MFLMGKHKPIYDPSTDCGDYVVALGCRNLRTTGKKRAQKLYYTHNTRPGSLKSMSMDQMIEKWGGAEVLRKAVKGMLPKNRLREKRMARLKAFEGLEHPYKENIVKLNGQNTSITDMPEVREALQNAKTEALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBQ7</accession>
    <name>D4DBQ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021351.1">
        <property type="nucleotide sequence ID" value="XM_003021305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBQ7"/>
    <dbReference type="GeneID" id="9578183"/>
    <dbReference type="KEGG" id="tve:TRV_04558"/>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="17151" checksum="245A0038B75FC711" modified="2010-05-18" version="1">MFPPPPPPHWAVDMNSPAPSRASKSASFPDPPGYSAPKSVSKQRAQPSTSPSSTPSKTETDALKLKKAWELALAPAKQLPMNAIMMYMSGNSLQIFSIMMVFMLFKGPITGIIGTNAAFAKLESESIRGQMVAVKVVYVAMQCVLLALGIWKVNGMGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC05</accession>
    <name>D4DC05_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021225.1">
        <property type="nucleotide sequence ID" value="XM_003021179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC05"/>
    <dbReference type="GeneID" id="9578070"/>
    <dbReference type="KEGG" id="tve:TRV_04657"/>
    <dbReference type="HOGENOM" id="CLU_057145_0_0_1"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="275" mass="31475" checksum="666671F0388E13C4" modified="2010-05-18" version="1">MPFDYLEWLVPVLPESWLIFLYEQAKAQKTTHLHDDPYVRPVIRISDKIAVKCGHGVAPGEAATQQYAYQHLDRRVVRVPRVYRYFQVKSNSSWPIGYIFMEYIPGKTPEEVDLNNDDISKRLADVVCELATVSGGATPGQINGGTLEGYLWGDDGTKDVFHSVDDMNHWLNRRLKLLNKEIDLRPYPLVLCHLDLCRRNIKLLDDDSLCLLDWGHSGFFPRFYEVAAAQCINDDGAYIRSLSNAVKSKANLSEDEEKCVWLILRARAASLRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC55</accession>
    <name>D4DC55_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021190.1">
        <property type="nucleotide sequence ID" value="XM_003021144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC55"/>
    <dbReference type="GeneID" id="9578034"/>
    <dbReference type="KEGG" id="tve:TRV_04707"/>
    <dbReference type="HOGENOM" id="CLU_048935_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="31928" checksum="95664ACD68B99703" modified="2010-05-18" version="1">MRPKRGDLERPLRLPMTKESVVGFDGAVTSIQNLAFTAIFTLHLDIRCGSIYMISRALKGKNDGQPQEPNRNSSTENNWSYILTVEPTSASPIVLELNNDLISFGARMSNYLGPNECRYITSCLSRLIDRALVSSTRFIGAMNSYGALRLQLDVLVLQQNLKNIIVVSPSPVSSKSSLSLDKDVAASMPEVVALPQSAKFLDWFLEGPGKTLRNAKEERDMFKEMGSQVLTEGNGEPFTFDELRVLIELCYSAALKGPQGPEAREEFMAAKRGLDDSLLRLSEVMWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCA2</accession>
    <name>D4DCA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein cox15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_04755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021140.1">
        <property type="nucleotide sequence ID" value="XM_003021094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCA2"/>
    <dbReference type="GeneID" id="9577983"/>
    <dbReference type="KEGG" id="tve:TRV_04755"/>
    <dbReference type="HOGENOM" id="CLU_017627_4_2_1"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE40522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56374" checksum="CFA5D2FFE085BCE3" modified="2010-05-18" version="1">MTNQGNNEIPKVQSGELYFVPEDEKLLLKKLKQSKQLKKLKKPKSQQSRELPGHISIKRDTSKYTSGLLAAFRAQPSKPVVPRSFFTTAATPAVGEAVSKSRFPDISSEGVAYWLLASAASVFGIVVFGGLTRLTESGLSITEWRPVTGSIPPLNEDDWESEFAKYRASPEFKLLNPNMTLQEFKSIYYMEWIHRIWGRFVGLSFVIPAAYFVATKRVSKSMSLRLAGIAGLIGFQGFLGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLGAAFVCYVAMLWNGLAILRSHRLLADPVKGLEVLQALKNPKLAVFRRSVAGLALLVFITAMSGGLVAGLDAGLIYNEIPWMGNGLTPPKEELFDEFYSRKEDRSDLWWRNMLENPSFVQLDHRILAMTTFTSVMALWAYSRMPAMKRLLPRAAKKGIHGVVGFTALQLTLGISTLLYLVPIHLASAHQAGSLFLLTWVMVLGSRIWHPSRTARLLQQAVKAKPLSSTSHAASPLANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCQ9</accession>
    <name>D4DCQ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021049.1">
        <property type="nucleotide sequence ID" value="XM_003021003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCQ9"/>
    <dbReference type="GeneID" id="9576696"/>
    <dbReference type="KEGG" id="tve:TRV_04914"/>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="366" mass="40870" checksum="74B0B333EFB3E8A3" modified="2010-05-18" version="1">MATHETMATNGNSGISADEIALYDRQIRLWGMKAQERIRNANILLVTLKALGNEIAKNLVLAGIGTLTIADDGVVREEDLGGQFLVTEENLNQSRVEAAAPQIRQLNPRVKLIVDPSSIKLKPPVYFEQFDLVIATDLDFETFSTINAACRVANRSSYMAGVHGFYGFIFADLISHTFVIEREKSNVAPQTNETPTRTVLEVTTKVENDKTIEMVTKRETYTPLLLANTSPLPEEFTRLPRKRKQVTPLLTCLRALWDFERQHGVPPSFSRQDLENYTRLANERHLELQLDPSTLTAAVLRSFLQNVGSEINPVAAFLGGSLAQDAINVLSQREQPLQNFLIFDSEKSVAPVYSLHPFFPDTTNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCT3</accession>
    <name>D4DCT3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020944.1">
        <property type="nucleotide sequence ID" value="XM_003020898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCT3"/>
    <dbReference type="ESTHER" id="trivh-d4dct3">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9577794"/>
    <dbReference type="KEGG" id="tve:TRV_04938"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="257" mass="27742" checksum="1AF0B6551636B533" modified="2010-05-18" version="1">MMKPTIAVVPGAWIPEHFYSPYIHTLEKAGFETRYAEYPSLEPQNPLTADCATDAKAVRSILEPLVETEGKDVVLVMHSYGSMPGCAAAKGLSKTERLRAGKLGGILGMILFSAFLVPEGLSCAGVQGGTLPPWIMLDNPAPGLNVPKDPINVFAADFDHGLSKKTEQELKPHSSLAFFSPQPPTACTDPAFKDRLAYVVATNDLAVPKDAQYAMIAGTGQEWKIKEVPQSHCAPFKVDLDENVKIVGEFIEAFQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCZ2</accession>
    <name>D4DCZ2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020922.1">
        <property type="nucleotide sequence ID" value="XM_003020876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCZ2"/>
    <dbReference type="GeneID" id="9577755"/>
    <dbReference type="KEGG" id="tve:TRV_04998"/>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="39463" checksum="AB5D2EF5C71D5F2D" modified="2010-05-18" version="1">MSSHGVLRQPAANQRTEAQRQAELTAITEYQALDTLVLQKKAKGEFSKEAFDKTSELLLKNAEYYTVWNYRRMILQSMFSEDSTQEGQPTDHTQQLIQQDLGFLVPLLQKNPKCYWIWNHRLWLLQQATERLSSAVSRKFWETELGLVGKMLNKDGRNFHGWGYRRAVIDALENIPDGPSEATGKEAPKSMTQDELDYTMKMIGTNLSNFSAWHNRSRLILKVLDESAADDEKRKKTLDNELSPQTMAPNLTTKDRLQYLEQEIEAIEDILEDTNDCKWVYQALITYTLLAAKINKHVDDVQQQRISTWLSELMRLDPLRKGRWDDLKESLATPDALISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD56</accession>
    <name>D4DD56_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05063</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020837.1">
        <property type="nucleotide sequence ID" value="XM_003020791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD56"/>
    <dbReference type="GeneID" id="9577576"/>
    <dbReference type="KEGG" id="tve:TRV_05063"/>
    <dbReference type="HOGENOM" id="CLU_005327_1_2_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="480"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="208"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="852"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1034"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120814" checksum="7F1890063342B2D7" modified="2010-05-18" version="1">MAATPLAAYDNNYPEQEPEIDSEQDAEGDEDPEFYDATAQAGIVTTYENSTVTVDGTYHGKGDTDEGGAVDENNVNHEKEPSLIDDGNDSKEKVDQDAAVIGSASEDGKSASEADELDAEFEELSNESNAVASEASSESDSEAEEEWEAESNEQEDADTEPPVENNCIVCKEDEEHDPSEVFEEPLICDTCSVHYAGKWKCPLCKHLHSQPDTRNSSTARQKSTVSSVTKDLLPADNDTQDPNSHSVFNSLIIEDDPLDGSRSLRKRKSSSYEAENRRSTTRKRRKVTPPHGQALPTTRASGSRSRAPSQNQLAENDVTTVHENRAPRQRRTRNAQKYYCSVVQKQEGRLILSFNLDQEKIQKILNSKPRPRSQRRRPLPKPPTIPEPPLVSHFAPTNPTPYAAPFYSFHDRENDELKSKPYGGILSEAEADTSRTVPLSTDRDKFEAARQKAEEEWRKKMMANEEDSDNALLSSQKLSGPPSKIKYINFGGYEIETWYAAPYPEEYSRNRVLYICEFCLKYMNSDFVAWRHKLKCPAKHPPGDEIYREGSVSIFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVMTEYDEWGCHFVGYFSKEKRPSSSNNVSCILTLPIHQRKGYGNLLIDFSYLLTRLEGRTGSPEKPLSDMGLVSYRNYWRLVLCYKFRDKKSPTSITAISEQTGMTPDDVISALEGLSALVRDPVTKTYALRLDYDFFERYIESWEKKGYVKLNPNSLVWTPYIMGRSNKSHYDHAPIHTVAPREEIDADEPTAATNSIPSNGYGLGISASDADTANSVAGSGADTVNTNGKGFSEASPSLFDAPGPPSTSALSFADVMAKQAPSTNGRQSSSTPSNPAFGIPPTRFEIFPPPQGASTSTPTVKRRPGRPFGTRKKVRSTAQSPARTSGHNTPKKSKPLRLGTPSTATRPLRFSVRRARSSMLGDNPDTKHDTDPESPGGTKRFDYPNPFASTSNGPADQPEANGSPGSDKNDEETHINKIPESMEIDRQLLNGIEDHTRNHQPQLVDGTNKNDTELTNGLTKPMDDTSQTIATQVGNPGENGASDAPSEKKIPLQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDD1</accession>
    <name>D4DDD1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000262">
        <property type="protein sequence ID" value="EFE40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020757.1">
        <property type="nucleotide sequence ID" value="XM_003020711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDD1"/>
    <dbReference type="GeneID" id="9577455"/>
    <dbReference type="KEGG" id="tve:TRV_05140"/>
    <dbReference type="HOGENOM" id="CLU_2063188_0_0_1"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="119" mass="13476" checksum="CCA3E26CF49DB1F5" modified="2010-05-18" version="1">MDYLLDIYHFEVDPTNRVDGDTPLHLAVQYGNEKDIELAMSMLEMMLEAGCDPRVRNKKGQKPADCVMPQYNQMRTALMKVEYMMQEGQGVEGQGRDDDDDGPSDGPSDDEDNGQEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDM2</accession>
    <name>D4DDM2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020707.1">
        <property type="nucleotide sequence ID" value="XM_003020661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDM2"/>
    <dbReference type="GeneID" id="9577406"/>
    <dbReference type="KEGG" id="tve:TRV_05233"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_2_1"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="144" mass="16011" checksum="B9EEF7F021CD3743" modified="2010-05-18" version="1">MSAIQGKCHCGAVEYTAKLGDKSHILCHCDACKRINGSDFTLNQVIPKADLEIKKGDLTKYTYKGDSAQLDIDYEGNSVHCFFCPTCSTHIYHHQTVLGDDKFILRTASLEGNKDWPASVEIYCKDRAKWQPDVAPKVCQAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDN4</accession>
    <name>D4DDN4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020647.1">
        <property type="nucleotide sequence ID" value="XM_003020601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDN4"/>
    <dbReference type="GeneID" id="9577351"/>
    <dbReference type="KEGG" id="tve:TRV_05245"/>
    <dbReference type="HOGENOM" id="CLU_071379_2_0_1"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="214" mass="24071" checksum="44437F09239786C0" modified="2010-05-18" version="1">MALSCVAWRATPTTSSYIYNSRQLLRPILRRRVHSEPSSSSRMRLRLQSFNNRLPKFLRSYTTPLFNAPVTHITSFLILHELTAIIPLFGLVGVFHYGGWLPSLGNPDGTSSVDEGVRKFGKWLRKRGWVQDVEDMSTMDRGAIRVEDSASELTAKDRQGLRLVLEFATAYAITKALLPLRIAWSVWATPWFARTVLGPVGRAVGRLASTNKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDQ7</accession>
    <name>D4DDQ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000269">
        <property type="protein sequence ID" value="EFE40019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020637.1">
        <property type="nucleotide sequence ID" value="XM_003020591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDQ7"/>
    <dbReference type="GeneID" id="9577335"/>
    <dbReference type="KEGG" id="tve:TRV_05269"/>
    <dbReference type="HOGENOM" id="CLU_018994_0_0_1"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="478" mass="54417" checksum="365E0B9077C496F2" modified="2010-05-18" version="1">MERPDLQRVKSEPVNLPQSQSAPISGNVETVVVAQEEPPATTPEGGRSPLALSPLSRISSEGSSSYQEDWEPLTPVERVTVLDLLGNLAISQKLEKWQASLNAQKERVKRHQEKFRSTSQQARQRVVGEFKKRMPSSEEQLQKYRKRMKSSVERLAVRWNDTVTVTAIEKISFIAGVLNVFISGYLLGAFPTYFYLWFTGQLIYFMPQRYYRYCKIGYHYFLADLCYFVNLLTILSMWVFPNSKRLFLSTWCLAYGNNAVAIAMWRNSMVFHSIDKVVSAPGSPEHYTLGAMMIWASVPYAIWQLSYHFFITVRQRDKIAAGRPTSFTWLRPSYAKTWIGKFVLHLSLPLQEPAFMMIHAFLTVMFIWSIYNGATFYIDVFGKRFQKELEQLKRDVAKWQMSPEALTAVADPQDPDGIKAASLTGVVMTTPKQPYVEPSQLITNLDLNANSKATSTGALVDEPASHNTTNRRPQDASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE09</accession>
    <name>D4DE09_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020544.1">
        <property type="nucleotide sequence ID" value="XM_003020498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE09"/>
    <dbReference type="GeneID" id="9577243"/>
    <dbReference type="KEGG" id="tve:TRV_05373"/>
    <dbReference type="HOGENOM" id="CLU_1312825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="210" mass="22697" checksum="BC51D0D16FE65A6F" modified="2010-05-18" version="1" fragment="single">MDDRGWGAVGWESAGGSTMAGCRWRSILGRRRNELATLSSSAAASRARFFSSSFSGFATHSTKFSLHPLQSNQIDRPTMAPELRKRKAPAPAPVAEPKAKRGSKAGAKAEPKKAAPKEKKAAAAAAAAAPPAEPEKADKKEEKKEEETEEKKEEEKKEDKGEEAEEKAAGCVPEEGDVLDLSQFEIEIELNDGTKTSFRKLLEESKEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE71</accession>
    <name>D4DE71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NRPS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020471.1">
        <property type="nucleotide sequence ID" value="XM_003020425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE71"/>
    <dbReference type="GeneID" id="9584210"/>
    <dbReference type="KEGG" id="tve:TRV_05438"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="419"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="533" mass="57434" checksum="8CBAB5B882416260" modified="2010-05-18" version="1">MTTLSTAFARSGDQPAVIVPGKPAPFIASYGTLSADIAAFQGQLAKLGVAHGAAVSIALTNSYEFIVSFLASSWQRAIAAPLNPAYKQEEFEFYIDDLSSSLALVPRGAYAQNSAAVRAAKKYNAAIAECYFDSGKVVLDVKEHGKLAGKGGLQVQTAQPDDIALVLHTSGTTGRPKAVPLTHQNLTRTMRNIQATYSLTGDDRTYLVMPLFHVHGLLAAFLAPLQSGGSVVVPPKFSASEFWSDFITYKANWYTAVPTIHQILLKHPFPSPMPKIRFIRSCSSPLSPKTFHEIERAFNAPVLEAYAMTEASHQMTSNPLPPGKRMPGSVGIGQGVEVRILDDNGKEVPQGSEGEICVRGENVTKGYLNNPAANKSSFTKDGFFRTGDQGKKDKDGYVFITGRIKELINKGGEKISPIELDNVIAQNPHVAEAVSFAIPDNMYGENIGVAVVLKKKGSISDDQLKSEIAPKVAKFKVPQRVSIQQPQTCELLLASTLTNCYSLSQRSGSSTKSQRLLPVCISSLEKCNHGMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE98</accession>
    <name>D4DE98_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000288">
        <property type="protein sequence ID" value="EFE39827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020445.1">
        <property type="nucleotide sequence ID" value="XM_003020399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE98"/>
    <dbReference type="GeneID" id="9584187"/>
    <dbReference type="KEGG" id="tve:TRV_05465"/>
    <dbReference type="HOGENOM" id="CLU_2484950_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="87" mass="9487" checksum="8662EE7A8B27183A" modified="2010-05-18" version="1">MQKKKGYKKMEERRRKKEGNIFLLVFSKYFNAREKESVASSASRSSHAALSQFWLYIFIAAAAAAAASTAAAGSSACPVSILQQASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF33</accession>
    <name>D4DF33_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000328">
        <property type="protein sequence ID" value="EFE39542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020160.1">
        <property type="nucleotide sequence ID" value="XM_003020114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF33"/>
    <dbReference type="GeneID" id="9583929"/>
    <dbReference type="KEGG" id="tve:TRV_05778"/>
    <dbReference type="HOGENOM" id="CLU_3353557_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="37" mass="4648" checksum="3A33BE69E945AFDB" modified="2010-05-18" version="1" fragment="single">REKTEEEEEEEEEERQKDQPLPRKILFLFFSAIYLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF61</accession>
    <name>D4DF61_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000334">
        <property type="protein sequence ID" value="EFE39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020136.1">
        <property type="nucleotide sequence ID" value="XM_003020090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF61"/>
    <dbReference type="GeneID" id="9583900"/>
    <dbReference type="KEGG" id="tve:TRV_05806"/>
    <dbReference type="HOGENOM" id="CLU_052827_2_1_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="183" mass="20653" checksum="A615DA10FFC8D49E" modified="2010-05-18" version="1">MSSEINLFAGPIIEPDSPEDIEITTSLNSRFDQLEIVKKLREDPDYTEWEPYGNFTEEEKKARLTKNTLKSVLYLGNGLDGWPTVVHGGAIATILDENMGRLAIENLPERTGVTANLNISYKARLGRDQYIIVEAKYDRLLSSERKAVIEAVIKDGKGKVYSEAKALFVYPKKLKLRTLGEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFE3</accession>
    <name>D4DFE3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020116.1">
        <property type="nucleotide sequence ID" value="XM_003020070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFE3"/>
    <dbReference type="GeneID" id="9583880"/>
    <dbReference type="KEGG" id="tve:TRV_05890"/>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38357" checksum="881AC23427A90459" modified="2010-05-18" version="1">MKICEDRNLKVEESKRDRQRKPGTKRGESGLNQHKMAPRVGSSGLCSWFSNLTLSRVGSQQSRTVTTKGHGRRQRDPFAIAQARQRKAANISRQRELSQQRTEAFGDPVASEKTPMIEAMLNPSLYPTLGSKGVHVPSDNEQPSYVNYCISKSELASALETSKQLTRPVPPIDGSVVDPQQVEDAIKKHEEDHKNAEEAVRRILAMKNGSTRNRTKLNIKRSIDILGRHNTDRVLPPKPAAAGQDPASLESSAKRPRAGPDTGSPEVQVAILTSKILVLAEQLKTTSHKDKHNKRRLRLFVHRRQKLLSYLRRKERGGPRWQNLMQTLGLSDAAWKGEITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFY8</accession>
    <name>D4DFY8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019893.1">
        <property type="nucleotide sequence ID" value="XM_003019847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFY8"/>
    <dbReference type="GeneID" id="9584644"/>
    <dbReference type="KEGG" id="tve:TRV_06091"/>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="34994" checksum="C87644E37E48D96E" modified="2010-05-18" version="1">MAESDSSQPPPPQPQSNQVDVAQPSSQAVAQQPASSVPKASSSASPPSQTQPQMQTSQALPQDTAAPANQDSSEPVIKQQSPSSNPSEPAVAATGEGGSASSLAKDVDLSPQGANIKDTNATEDITMGGTEPEAGETTVQEGAGVTAGGAATTSTANVAPGIPEPAPGLTGLESIVPPSKKDTSLREFLSQMDDYAPIIPDAVTAHYLTVAGLPPPGPGPNNTPPHLARLLALATQKFIADIAADSYQYSRIRSSNSASSNNPMGSINVTAGLSSAAQGGQPGGAGAAGAAGTGEVSTKGKSGAGGLHLGVQRAGFGGGGQGGSQGKTVLTMEDLGMAVGEYGVSVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI7</accession>
    <name>D4DGI7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019662.1">
        <property type="nucleotide sequence ID" value="XM_003019616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI7"/>
    <dbReference type="GeneID" id="9583579"/>
    <dbReference type="KEGG" id="tve:TRV_06291"/>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="458"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136216" checksum="5A4FD06B6B46BA1B" modified="2010-05-18" version="1">MSASPSESPAPEPSGMDSQHSGIMGDLAEDDFEPAEEDDEFDKVVQRMNEPNANMDFLTRDLEIGEKADDAIDYEDFDDDELPDEEVVAPSARLPTAIPQDDDLGDLFGGDEGFQGGQEGEGDELDDLFGDVPSSPAQKQPGMGLSLPITDHSMEAAFGESGLSQRSLEVHDDIFAEDIENEKEAPPSPTLDMDPATLRDYQLQQALFAMSAYGPDNPPAPPENNEELLASLWPKFDKDALPRFMELIPPKKARFIGKAPIKPPKRINPTKINIELAPDQERAFLFTGQTQKKPVESDQFITVMTPPSMSAESSDVEGGDDSDEELPGGITMEDLQFICADWDVKSPTPENDTVATPEVPQNDEDDWLFEVAQPTKKRKLGRDPADYLSYSHIDLPNLDDPAEATALLARKIRIDMNDPHLLLDDYSNNEPITKIKSSKLQSTNEISSGLTKRLMQRYNISNDAAYDMLKENHQNKVRSTLGNIALEHSLPAIRLQWPYYKTKLARPEARSFHRPSLTFHPNLPLTFKVPAYLKRKHQKGKDAKTLFDTTKSLSLADNSNALLIEHSEEYPTMLSNFGMGSRLINYYRKKNAEDPSRPKTEIGETAVLLPQDKSPFSSFGHVDPGETTPTITTGLYRAPVFRQEVKSTDFLIVRNSTGVEGSSYFIRNIDHLYVAGQQFPSIDVPGPHSRKVTTAAKNRLKMICYRRIKRNGNNRVSVAEVTEHFPDSTDMQNRQKMKEFLQFNKDHKEWEMKSGESVPSEDVMRGYVKPEDVCLLEAMQVGQQQLHDAGYDRESDNGDDYEGKEGESLEQQLAPWKTTRSFLLASQGKAMLQLHGEGDPTGRGEGFSFIKTSMKGGFRAVGESVEDKIDAQRQKELGGHSYNVARQQKSYEEAIRRIWESQKSSLSSTVHHSDEESDVDMGEADELFGKPTPRSDRPTPSFSRRDDETTSQFSRFSTSSQSGKVMVISRQIRNNKGQIETVKEVIRDARVIKQYQKQRHEADLANMTLVDIQPTGNPEVDARNMKQYVYTALSSTCISQCISNKLFSYSIEDELRRLQRNKERRHAREKQKSVMAESNREMSPNTAAGSPAASGSGGPKTGGTQRKCANCGQVGHIKTNKNHLHLRTRTPDSLSTNTTDTILLSSPTFNIPFLPIFIFIQQKKHWDIFLSLVHNRPLNQHNLLTKFFRLCPLLNGSMRPEDASNLPAFALGVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGR6</accession>
    <name>D4DGR6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_06371</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019575.1">
        <property type="nucleotide sequence ID" value="XM_003019529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGR6"/>
    <dbReference type="GeneID" id="9578349"/>
    <dbReference type="KEGG" id="tve:TRV_06371"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase dimerisation" evidence="15">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE38930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="304" mass="32733" checksum="4640EC95869F452A" modified="2010-05-18" version="1">MPAKVADLTVRRCDPAEFSDCDIIFSGLDPDAAGEIEMAFLKANFAVFSNAKNYRLDPMVPLVVPLVNAGHIDVIPAQRKHFGLDKGMLVCNSNCAVVGLVVPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPYIPGEEGKISSEARKILGDLNSDLAGFSDQKPLQISVACNRVPVLDGHTVCASLRFVNRPPPTASQVREALREYKPEVQTLGCPSAPKESIHVMDEVDRPQPRLDRETEGGYACTVGRIREDDSGVFDIQFVALSHNTVLGASGSSILNVSFHFPPTVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHE8</accession>
    <name>D4DHE8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase activator Bem1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000379">
        <property type="protein sequence ID" value="EFE38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019375.1">
        <property type="nucleotide sequence ID" value="XM_003019329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHE8"/>
    <dbReference type="GeneID" id="9577778"/>
    <dbReference type="KEGG" id="tve:TRV_06604"/>
    <dbReference type="HOGENOM" id="CLU_014957_0_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="378"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51145" checksum="CA0B507DCA828E1F" modified="2010-05-18" version="1">MSSLGKTGATAMVYGIVMYDFNAERPDELEAKAGEAIIVIAQSNPEWFVAKPIGRLGGPGLIPVSFIEIRDMTTGKSAPDPLEAVRRAGVPRVEEWKKMTAEYKNSSISLGKFENGPQQAAAELERMSLNSRSNHQRSPSKHGYSQQPPQQPQHYQVPIPVQASIPRYCFDNDKYWYIVEVQMEDGRWWELSRYYHDFYDFQIALLSQFEEEAGNRGGQRTLPFMPGPVTQVTNAISNGRRQSLDEYVKQLLAMPPHISRCQLVRQLFAPRPGDFEIDPAVMSDDYRLSSGSQQSSGHNLSRTASRQSSQGQMSGPNQQAHYQPSQRPTHQRSQGSVSQQYHQQPHQQMPPPGQAQAPSMSRQGSSFNSQMPSQGSGAIKIKVFFQDDIIVIRVPDDINLRQLTDKLRDRLKVDSMIIRYKDEPSNSFVELLGDADLETAIRRNAKLMLYVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHK0</accession>
    <name>D4DHK0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CCCH zinc finger and SMR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019312.1">
        <property type="nucleotide sequence ID" value="XM_003019266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHK0"/>
    <dbReference type="GeneID" id="9577634"/>
    <dbReference type="KEGG" id="tve:TRV_06656"/>
    <dbReference type="HOGENOM" id="CLU_015244_0_0_1"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="650"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="90265" checksum="AF667B2942FC0BA1" modified="2010-05-18" version="1">MVSEETYELCLHILNNEDDNEEEKAEKLEAFLRDQSSLAGSALENAVLDVLWRHRSSSMADASQPPVRHTVIRRSSPAPWQMARSATPLSSPSHTGSSPVAQSGFPVPRGGFPRAPRSLTASPFTSPRPSPRLGKVLPIPHSPNLNTYSFSERGPAPEIYGDLGSDNVDWLVNEDAKSTASSTGLSAAAPEWVAPPDMSPYDILRSVLGERKTNEEIEHALEANGYDLGATIASLTEQDHHSHHSSSNHGHGQHHLETPSLSSSNEGRVLIGKSTAMDPARPVTPSTSARTPVVCKYWLSTGQCLRMDCRFSHDLTSHVCKYWLMGNCLAGDSCPFSHDPSSLIGSMSLGSDNLSVAGYSANNAAAAAAQHQHQHQQQHQQQQQTSLYPLQDNYEAFPPLQPPSTSSSAATTSNSITADQWHHRSQMQFMAGSPQMRPGSSSSIKNKNMLNPSATRSHSRPGSRHQSREQPATSAPAVDDPEAFPTLQALNSRPGKKHHGKRGTQHREVTKARDASGTSLADAVRMSPSAKKGAQKGARSSASGTTREISAEAQAIPSPKHIPWLETGVEWTQPYLKYRVDAITHGNVRNKFLQSAAQAWNRNDARAAKALSLRGQAENDAMRRCHREAARLLFEEGRKRIADNDDEFYVDLHGLVPTEAIAYLDNILKESSQLREHFLYVITGSGHHSKNGKDKVGKAVKGWLTEHSYVFRDFSVPGERGGFVAFVIGINPTATANSGRDSPSPTSPAISKAQSQTQSQSQSTDKPTGEISKAVAAAAAAAAAAASAATTDATPARDDTGDEDGSVTAAEASSSSPEPGPVLKMGKIQLLKRDGAATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHK6</accession>
    <name>D4DHK6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019318.1">
        <property type="nucleotide sequence ID" value="XM_003019272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHK6"/>
    <dbReference type="GeneID" id="9577640"/>
    <dbReference type="KEGG" id="tve:TRV_06662"/>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="595" mass="64860" checksum="F882CE21E843577F" modified="2010-05-18" version="1">MAEQKSAILSVYDKTGLLDLAKGLVEQNVRIVASGGTAKMIRDAGIAVDDVSSITKAPEMLGGRVKTLHPAVHGGILARDIESDKQDLANQKIAKVDFVVCNLYPFKDTVAKPDVTVEGAVEEIDIGGVTLLRAAAKNHARVTILSDPSDYTNFLKELASGGVTEETRKLYALKAFEHTADYDEAISGFFRKKYAGEGSQYIQLRYGANPHQAPASAFMRNGKLPFKVLNGAPGYINLLDCLNAWPLVKELKQALGYPAAASFKHVSPAGAAIGVPLNEKEKQAYMVDDIQGINESGLAQAYARARGADRMSSFGDVIALSDVVDVPTAKIISREVSDGVIAAGYSPEALEILSKKKGGKYLVLQMDENYTPPDEETRSVYGVQLSQRRNDANISPKTTFNKIVTPKDMSSLPEGALRDLTVATIALKYTQSNSVCYAVNGQVVGLGAGQQSRIHCTRLAGDKTDNWWMRFHERTLGIKWKAGVKRADKSNAIDMLCSGQIPRSDVEKADYERVFEEVPAPFTSEEREAWLQKLTEVAISSDAFFPFIDNVFRAARSGVKYMAAPSGSQNDGPVFETAEKLGIVFVEQRIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHT2</accession>
    <name>D4DHT2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000387">
        <property type="protein sequence ID" value="EFE38582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019227.1">
        <property type="nucleotide sequence ID" value="XM_003019181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHT2"/>
    <dbReference type="GeneID" id="9577476"/>
    <dbReference type="KEGG" id="tve:TRV_06739"/>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="489"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="825"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="954" mass="105984" checksum="2B7BD0B0353CDBBB" modified="2010-05-18" version="1">METAVRWSPSSTLDDQRFLYVDIPGKSFNLCKVTSRDDVLGALKYDVLSSRHSVPPFRAFDWSSADENLAVVGQSSGEAAVLRLDDDTQSPVVFPIRNQRSCNAVAFNTQGLLAAGLDKVRNDFSLNIWNVNQRLSLGSSARPFGSSRYPTEPLRKLASSEPITSIKFFKDHPETLVVGVRGQSVRIYDLRESSGSPSLQFITRCVHNIAIDWLDENYIAACFPSNDVAISIWDRRSGFRYPTAAGAASASADSGPLSTALDLKPDIESNSTISSLRFCRSKRGCLGMLTTTGTFRCYDIAKEYLSEENKSSLEHALGQDSSKHYPEQIYTRKVQDFRPSILPSGGAAKKDWQRVTSFDFLNKGVVSQPVAITLLADKTVSLFTPPPPPSSTDLSSKCSLSIGGPVCSDSSPMVLRPSSDLGLTASQINFGKTPNVLSSEEEHSHQSTSDHQIGETAETNHEKRDSAFPTDDTPSFDDALSWLTIPRLRCKEGYLLDSEKNKAIVSDNHSLQELWDWIGRVYSVWNGKLGRSFESRRDSSELAEERSISQLFQELVHKLNFAQSKTCESEFPEKRQLCLHICGAPESNDDLVNTVNKLVAERQHSKAAALAIFQDEVKLAYKALRENKPTQAHKLLAMAIIGGSKGDAGPDWEETCAEIAAELTDPYARAILAMVGNSDWMSVLQEATLPLKYRVEVALRWLPDAELTSYLRDASVQAIHQGDVEGVLLTGLDHAALDLFQSYINKFNDVQTPVLAMCHTVPRFIRDAPSKARFEAWRETYRHQMNSWKLHLNRVKFDIESRKLAITWESRRLVEPPLQQISLVCNYCTRPLTQQDTSNSEVATTPTEYSHATPGNPLGHPSMNGTACPKCNRHMPRCGICSLWLGTPDPMSKASIAEDSKKAASTTQSHDDIMRRFVAFCVNCNHGFHADHARDWFNKHKICPVAECGCICDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHY1</accession>
    <name>D4DHY1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019182.1">
        <property type="nucleotide sequence ID" value="XM_003019136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHY1"/>
    <dbReference type="GeneID" id="9577185"/>
    <dbReference type="KEGG" id="tve:TRV_06788"/>
    <dbReference type="HOGENOM" id="CLU_017452_3_0_1"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="373" mass="39867" checksum="AE6782FE54650DA4" modified="2010-05-18" version="1">MVPIPITIVTGFLGSGKTTLLLNLIPQLPSSYRLALLKNEFGDVAVDSQLAAASSISGVRELLNGCICCNLVGQLSDALLQLRDTVNPDRIVIETSGSAFPATLAMEVNRVSSERKGEFVLDGVVAVIDVENWEGYEDTSYTAKLQAKYTDLIVFNKWELVSERRFDICLDRVGDLDVQTAWVKSDKGRVDRDVLLGIDGALLAKMAGSTEITDALGQAENAHSHQSEVEVLSVSLAGDADADADADVVVDSAAFSAFLHSSPKDEIYRIKGTVRFAPGQVPADSSGEVTAAAVAPDAPPVQTYILNWAFGRWTLTPSPSETTTAARLTLILARYEAAKWKKKLEAGQLLKAASPATASLQVGIIGQKTAPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI83</accession>
    <name>D4DI83_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone-regulated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019066.1">
        <property type="nucleotide sequence ID" value="XM_003019020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI83"/>
    <dbReference type="GeneID" id="9582551"/>
    <dbReference type="KEGG" id="tve:TRV_06891"/>
    <dbReference type="HOGENOM" id="CLU_007968_3_0_1"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73535" checksum="A40EEF824A542EAE" modified="2010-05-18" version="1">MILYFNVIISLAVYALDTFTAVNLLAFSRWSSQIKPAIPLDISKWIFAGCIIFSLVLLVYRWLRAIRVIKSGGIAQCYLDPIAVKVQSIRTSKRASGWRRFLVFAELTKSRKGADYVAIFTYFNFEAWLRVIFAQGPRQVINGITLYSVAQLNLIPIGEHAAPEGTSAISQFFINIEALADKDRLQALILFSMLFTLVIWAFEFLSFCVSVLLYLLFLWHHIPSEDGTLSVYCRRKINRRLERIVKKKVDKALTNAVVLQDRKRTNTDIETGVASIKRNPTLPTLPSVMDLKQPQQPKLPEMPPLSRQTTVTTLPPYRPHTSNTDRPPPLPEADWDAHSHEHDQYDNDYNDHDHDQHGDHVMASSNSMHRTQYSDDASASLVNNAGGIGYSPPSSQYNYRPPHPQQQRDPMQREFTKTPMLPPVERYGTPLSVSTAPVFNAQGLGQGRRTPGPMTPGPRTPGPMMPGPGPRTPGPLTPGPGSMGRQTPSSHHHQQHQQQTWDAPEVPGLPVQSPQPTLPSISRPGTAFAPPPPVSTPAPSFSRDRERERYGPYDGPQMSSVPQIPSAPTPTPSAPPTHGNGAPYRNFARPSLAPYSAPGGQDIPPRSETAPLPSQGQYSHSQVGYSQTGSQGHGQQPDLRQEPQLPQIQPPNGTQNGSYPSFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DID2</accession>
    <name>D4DID2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TRV_06940</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019039.1">
        <property type="nucleotide sequence ID" value="XM_003018993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DID2"/>
    <dbReference type="GeneID" id="9582447"/>
    <dbReference type="KEGG" id="tve:TRV_06940"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EFE38394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="859" mass="96058" checksum="77D5AE517E532AC6" modified="2010-05-18" version="1">MERDFRHPYRPYDIQAQFMEALYGCIEDGGVGIFESPTGTGKSLSLICGSLAWLRDHKRSVFLEKADDDGDDGEPDWMVQHARRERTQEMLARRKELEERLARVREAEERHRKKLELASRLTKKMRVVNEKVRPETKDEDFELDDYESGDEKAGRPQDDGNPLSSDTLALLEKLKGPAQRIELEEGDESVKIIYCSRTHSQLIQFAQEMRRVMPISSIPPDLDDNLKEEKQVNQQDEGEWIKHTPLASRKTLCINPSVRSLSSATAINERCLEIQRPNVAAEQKCPYLPTKDNELKTSQFQDHLLARVNDIEDLPPLGTKMGICPYYASRTAMRASATEVITLPYPLLLQQSAREALNLSAKNSVIVIDEAHNLVDAIVNIHSVTVSLSQLRTALAQITTYARRFKSRLKGRNRVYIAQLIRLVGCMVSFLDGVGQNDRPDAELTVQDVLGGGKGKGGVDMINPHKLGVYLRESKLARKVDGYIEHTATQQANGGDGGGKKADGGMPVLFHVQSFLLPLMDPSDEGRLFYEKVGGDVQLKYLLLDPTSRFRELVEDARAVILAGGTMEPMDDYVNHLLSYVPREKIKTFTYGHVIPKDNLMAIPVDRGMDGTEFNFTFDQRRSEKMIISLGRTIARYCSVIPDGVVVFFPSYDYLATVLKVWSSNSGLLNSLSRLKPIFHEPQSTGSTNGSANANTNTDSLLSQYSASVDAGKGGLLLSVMGGKLSEGINFSDALGRGVIVVGLPFPNTRNAIWQAKLQHVEKKAYELADSSQPEDARRACGKAASRAYYENTCMRTVNQCIGRAIRHKGDYAAILMIDRRYQTERIQGKLPGWIRGSLLKNHQGDVPGQLQHFFQSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJE1</accession>
    <name>D4DJE1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair protein Rad1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000436">
        <property type="protein sequence ID" value="EFE38030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018675.1">
        <property type="nucleotide sequence ID" value="XM_003018629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJE1"/>
    <dbReference type="GeneID" id="9580828"/>
    <dbReference type="KEGG" id="tve:TRV_07307"/>
    <dbReference type="HOGENOM" id="CLU_035332_0_0_1"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000014">
        <property type="entry name" value="DNA repair protein Rad1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41938" checksum="3604E9A2E97927FD" modified="2010-05-18" version="1">MDITPVLSAVSTSTDQLYTLLRCIGFSRQASVQITPQGIRFSVEEGRVVQGLAFLDKALFTSYIFNVRNVHDGVTQPEKDGDFFDTSLYPRFTISLSALLETLQIFGISDSSQRPNQMTNIENTQCMHAFSTPALGMNRSCTIGYRRKGSPLCITLAEAGVTTTCELTTYEVEDSSQDSTPGEFDIPLQRDAIVFKIIMRSTWLHNAIIELDSTSPTVLSLSASPNKAPFFALSASGGPFSESTVEFAIDKESDGVDPAYKSFNEDGSSRQPKRNKLAPTVTETFLVEPPSSKSRITQRYRFSLLKKALGAMSASSKVSIRGDKQGVLSLQFMIELNDNASTDASGPSTQSASRTATGNVSFIDFRFVPLIDEEDIVEELGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF7</accession>
    <name>D4DJF7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018635.1">
        <property type="nucleotide sequence ID" value="XM_003018589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF7"/>
    <dbReference type="GeneID" id="9580786"/>
    <dbReference type="KEGG" id="tve:TRV_07323"/>
    <dbReference type="HOGENOM" id="CLU_360999_0_0_1"/>
    <dbReference type="OrthoDB" id="4172108at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="697" mass="77522" checksum="2157B7DA9712DC6A" modified="2010-05-18" version="1">MSFGWSAGDIYQLIVACHTLVSNCTLGPTSALQIVHGLAVEIQELERLLQQLQKLVQDGGETSCIDLRGIEDTLRDCRTHMQKYNKLQQAYENHHRNNTDPVVAGERRPSTTSTTGGRTREILISGRNAARVGGELVRHATWGSGQVSALQDRVSRHKQSLTLYLTVLERERSIRMGKRLQSVERMIHELHAEAMPLTRTYPLQRVGSIPSSGLGISDGSPADGDRYHIMLEAVERQREYAMLQRALAETGNDQEWETICDQLDRFHRRVLNVIERKTNSTAQHGCRSEHGSQSENDIELNRTLLNMSRGSLRSPANENQSYRRRRHAAFETPLERISDEIETETDHQSSHISLSGTEEVADGPGNPIYRTLSTVTLPSYTPSVFSDFTSTSTAATEDTAVTATNAAHMEIPGSHNKPSYMASPTQPLSASPSTVNSLSIPLSTSPGSIHSYSTPISPRFAPRQSPSNARDSISSYASTAPSVVSIENGNAPLRSRGYSNGNGSSFPPSPGMVSRRDTDDSGHHLSCGWKTIPLDGSVRIYLFSGVRFASFLSPCKRSNIAIVSSAERRTIPHIEPPGDRDRSHEAGVIYFIKAPKTKYGEHPKYYIEDPDDLIYLQSLIFGKNLLLSMLVQKISSVNGRESDRQYLRIWEETDGEGHDGDTSILYFASARERPRYIEVHREFANQQASQPSVYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJK7</accession>
    <name>D4DJK7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018615.1">
        <property type="nucleotide sequence ID" value="XM_003018569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJK7"/>
    <dbReference type="GeneID" id="9584544"/>
    <dbReference type="KEGG" id="tve:TRV_07375"/>
    <dbReference type="HOGENOM" id="CLU_816289_0_0_1"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="221"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE37970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="380" mass="42096" checksum="976E847B22B93D69" modified="2010-05-18" version="1">MLWSSEPGLSRLGIEIPLADTEFSAQSLSWSNYFKSTCMLSLLSRNWIWEEEEEEVTVVDEEEEEDDDDEVEEDEVVDRKSKLRLKVEAARRWLDLIYFSNCAVRSADRKNRLQIPRRVAASLLVHKPRLYSFAIQDTMPAQDSDKSPDYKANLLSILISSKVLSFGSYVLKSGRNSPYFFTTTLLHTAPLLHATASACATVLSSPPFVKSQEGKAVTPSFDIIFGPAYKGIPLCTAVLNELGVRDTQGVWDNVSYSFNRKEAKSHGEGGNIVGAPLKGKRIVIIDDVITAGTALREAVGIIEKEGGIVVGVLVLLDRQERVNDTETKSAVGAAQRDLGESIPVRAVLNLNDIIEKLGDDIGKENLEKLLEYRAKYGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJP3</accession>
    <name>D4DJP3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018566.1">
        <property type="nucleotide sequence ID" value="XM_003018520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJP3"/>
    <dbReference type="GeneID" id="9584495"/>
    <dbReference type="KEGG" id="tve:TRV_07411"/>
    <dbReference type="HOGENOM" id="CLU_021768_1_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="341"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="634" mass="71787" checksum="61FB07633796BBD1" modified="2010-05-18" version="1">MEEALARHDRFGEDFSKVFTIINSAEIPAVENSALYLFVGTSRAPDEASKYVRDRVAQNAQSSTLEETLHSIHEELKILSKKMTREDPMNLDPEIEAALYERDGGCCFITGRTAGVQPIYIIPPSILEDKDLQPGGYLRPLLEVSLTKEGTEQMLNLLGLPGRENVLKNLILMEPSIRYSFRHGYFEIIKSPYLEPPYLPTDAPKSKNGGWWLQPIAPQSEVPQIIPRNNELYKVPSTINPISHPLPARLLLKTHGIVSHPLHTIYIEEQIKAGWPVEPEPKELNWVGRLLLQILLRLIPNFARIRLYELIYKMVDYWDPSQKGSHVKFLPLGLVLKKGRENTENEAKALTLAEQYISISTPRLIDSVMVNKTSGFILMTKVVGRSLSSILHRITWEELEQIGKDLANFITELRRIPNSSKYLIADTRGGPISDHRFFYQTWGPFKTVSGFTDRLLQDVKGARDKPPLSFLYEKKHKVYFTHSDIHMTNLFVTCGRLSGVVDWENAGFKPEYWEYIRAMWAYGADKHAKCLYGSAFGDKYKEEGGIEITAVWIGFSLTTFSGFSGLIFEQLIRLRNEYLPLAQGKISPDVNPGHLCSTAKTSYTSAFARWEAVPARPMPTSQSGPITAKDAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJQ8</accession>
    <name>D4DJQ8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018581.1">
        <property type="nucleotide sequence ID" value="XM_003018535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJQ8"/>
    <dbReference type="GeneID" id="9584510"/>
    <dbReference type="KEGG" id="tve:TRV_07426"/>
    <dbReference type="HOGENOM" id="CLU_014492_3_0_1"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF2">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="837" mass="90578" checksum="B78A37F459BF575D" modified="2010-05-18" version="1">MDALPKIKCSDCHAEVELVALGDHVCSKAAGPTVTTSPVEEKLSVAEFNEHGPPPKRSLSRESLFNRLGRVQPPPRIDPTAASTYISSHGYRGIMASGLTVHANKFLDRPFLSPGAQMSPHTGSFGALTPRSASPLSPLQQLQRSHTSPVASQSSVVAVVPEGKANLDCAFPPFPRSASAGGSKAKRLASIRSINTNVSSRRGVTSPSPSDGSYMSPSTDGRSSRATTINRHRREASIDSKAFQRLSMTSSKNGHGLPSPVSPRGSSRSRHEDRDIPPLPSGPIASLASSPVFTSGNSEPFYFGSSDNNDKSDQDQDPPETSPRDKVRQLDGMEGLDFGFTTRTKSPEMMDVDNKLENIEEDDSERAPDSPGPSVSEYKLDREFSVSNFASGLGISDPCHTANDSTSSSNSSPSEAPSNSSFSSRPSESSNISEPKSSLSEKYNVDRLRLLQEEPPTRPKVDPFAYELDSPTDPLFQQGRLSDPPANTFPSSSETKYSTPSIQLEPAQPKKYTPYRSPTQSLNSQSSTFEQQQQQQSPSSPPLQPEVQPEPQEVREQQQQPPPVPEEESAAQPLPPSRSATPGKRHHPCRGCGEIITGKSVSSADGRLTGRYHRACFVCYTCHAPFQTADFYVLDNHPYCAADYHRLNGTLCAECGEGIEGPCLEAEDISPSNGVGISSSKKSQKFHPGCFKCRTCHIVLRGDYFEWNGSAYCERDGRRAAGLMPPPRSPGFPPPHGYQGHPPPPMGPPGPGPGPGYRRPPPPSSPLAGPRQGGRGDPRYRPMNPSSLRPRPDKHRPHPSEHQFVNSSLTPAPGLDNGPYPSTRKFPERRTTKLMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJR6</accession>
    <name>D4DJR6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit Nas2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000443">
        <property type="protein sequence ID" value="EFE37904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018549.1">
        <property type="nucleotide sequence ID" value="XM_003018503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJR6"/>
    <dbReference type="GeneID" id="9584480"/>
    <dbReference type="KEGG" id="tve:TRV_07434"/>
    <dbReference type="HOGENOM" id="CLU_2374300_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="95" mass="9932" checksum="45634ECB34B6EF31" modified="2010-05-18" version="1">MGIPMDDIHTPTVPAGPVSGAGSTSTDLSKAGLTQLFDDKEKLEAELKILSDVLVSHGVDMNTNLLTEDGFPRADLDIAQSTVAQSTSFLGGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJS1</accession>
    <name>D4DJS1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000444">
        <property type="protein sequence ID" value="EFE37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018538.1">
        <property type="nucleotide sequence ID" value="XM_003018492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJS1"/>
    <dbReference type="GeneID" id="9584467"/>
    <dbReference type="KEGG" id="tve:TRV_07439"/>
    <dbReference type="HOGENOM" id="CLU_019189_9_1_1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="550" mass="63902" checksum="B446C6B38C9A5DFB" modified="2010-05-18" version="1">MISERDLFTYTSGRYLYNEKLRLAGRYVEFNVEALKRIAAKAVDRDSTASIKKLAEGGFNRVFLLTMNDGFEVIVKIPYLLAVPQKLTTESEVATLDFLRGKSIPVPKVYAWSSDKENEVGTEYIVMEKATGKPLTDRWFNITPKEMLKLVTSYVDIEKKLFSFPFAAHGSLYYKETLPQNLRVDLYSPGELGDDRFCIGPVTDYMFWRGKRANFDLNRGPWQDHCQYLQSIGERELEWTKKFGKPLMNDFPHNALENIPREISQDVYIDLLKKYLSLAPYILPQDPTDPMNKPTLRHPGTFSCASYLLAELTRVDLNPSNIFVSEEGEITCLIDWQYAAVLPLLLVAGNPPMFDNPDSEPPKDLEKPSLPPDYDTLSAEEREHADELHRQRMLFWLYMVFNGRDNKPHLTALRYPLLMPRQHLVDRAGRQWTGNFITLKGAILRVVSNWHIILGKRAGTIECPVNFTKEEEEEFYAIEEQWFQFNILTEHLRSKLDHLSEDGWVRNESYDKVVALNKEFKEEWLARGEDDDDRFLVEKGWPFQDHEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK96</accession>
    <name>D4DK96_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000454">
        <property type="protein sequence ID" value="EFE37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018381.1">
        <property type="nucleotide sequence ID" value="XM_003018335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK96"/>
    <dbReference type="GeneID" id="9584303"/>
    <dbReference type="KEGG" id="tve:TRV_07617"/>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="42687" checksum="F723D7C885077B4D" modified="2010-05-18" version="1">MSSSQSLYGIRRQKSEASKKDLVSSSTLAFTTHLSSLIAKESKASSPGAESPSGSTVSRGRARKSQKPDIFSVHNKGAQKRAAADLSSDNAALQIHKRGADIGEVDDAVLNRSKRKMIEKTKLYEELQKGEYLAEEDSDSDEAGQPDDRFSAIRRADKNSLVNFDRKWAESRESEIGTKDTSDDEITFVEYEDEFGRTRTGTKAEAAEAQRNRQLQQERSSMDGEEVERSMKPSRVPVAARPSRPSNVIYGSAIQAAAFNPDENTTAQMSNLAKKRDKSLTPPPETHYNAEGEVRTRGTGFYAFSNDEEIRKKEMEELMASRSETTIERDQAAMKKEAREKAKQERRKKIEELRGKKRADKFLGSLDTLLPSGASSEEAGGKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKE2</accession>
    <name>D4DKE2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000467">
        <property type="protein sequence ID" value="EFE37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018319.1">
        <property type="nucleotide sequence ID" value="XM_003018273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKE2"/>
    <dbReference type="GeneID" id="9580021"/>
    <dbReference type="KEGG" id="tve:TRV_07664"/>
    <dbReference type="HOGENOM" id="CLU_1107772_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="202" mass="22725" checksum="ECDD21A55FAF9949" modified="2010-05-18" version="1">MSKSRPLSISELSYFNNARNNLELELQSVQQTLPSYAKDRDDLLRVAEVKRLTALLYLRQRLGTPRNSSILSPVSVGLYARYPITFNTNTTRASPSPGPLALVESSTLAWKEKLVTDIIAIISTLPGTATLLWPLFVVGSVDIDNEEHRRFILERLQNIQNSRNLGNIRRARLAVESAYRARDLDHPRGNDWGREGRGISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKJ4</accession>
    <name>D4DKJ4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018266.1">
        <property type="nucleotide sequence ID" value="XM_003018220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKJ4"/>
    <dbReference type="GeneID" id="9579962"/>
    <dbReference type="KEGG" id="tve:TRV_07716"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="493" mass="54577" checksum="FF6F8C14E205DF52" modified="2010-05-18" version="1">MATVLPPPSKRQRREIDEKARQQQEIDSIPEDLGSVRVQFFDQSTGTASGPAVAVPLGDATVKNLEILLNTLQGHDDHERIPYRFTYKQGDKDGDVIDISSDLYHSLLQPGIKTTEDIIHLQYTPQAVFRVKVASRCSASISGHGEAILATSFASSSSSRMVSGSGDSTARVWDCDTGTPLHTLKGHTSWVLAVSWSPNDNIIATGSMDNTVRLWDPRTGQALGAPMKGHTKWIMGLAWEPYHLQSPGKPRLASASKDSTVRIWDVVSRRIETVLTGHKGSVSCVKWGGLGKIYTSSHDKTIKIWNSESGSLIQTLSSHTHRVNHLALSTDFVLRTSFNEHNQKPPDKEEEKIKLAKERFEKAATVNNKISEKLVSASDDFTMFLWDPEASSKPVARMLGHQKEVNHVTFSPDGIYIASASFDNHVKLWNARDGKLLVSSSKDTTLKIWDVRTGKLTMDLPGHQDEVYAVDWSPDGERVGSGGRDKAVRIWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKV8</accession>
    <name>D4DKV8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018136.1">
        <property type="nucleotide sequence ID" value="XM_003018090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKV8"/>
    <dbReference type="GeneID" id="9579345"/>
    <dbReference type="KEGG" id="tve:TRV_07832"/>
    <dbReference type="HOGENOM" id="CLU_047847_0_0_1"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="285"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="375" mass="41428" checksum="9207F790D85BAB70" modified="2010-05-18" version="1">MTDLTPAVNDLLRARGSSLLSGETSSPSDAQVDEFLKEAHRINVHISSLLAYLRSIRTVYLSTVPARPSGHTQNTDFNPLSPSSSSISSHLTDPERDSIDSSTASLLQDLSRSIGNLASAESLRAQTQASVLRKKYGHGKLNERLWQWAGGGGPVDVPRSSEQEEAEDTEKNIVGMRESVLWFLRRGLEGAAEVQREMVEKRIERVREKEKSVLYKAKAGQMPIHTQAEGSSGGISGGSGRYDGGDEDTLRGRDVSIDEKEAAAIESQLSPEQLQLFAQENDGMLKYYEDTLGKVQNAEKSLLEISSLQQTLVAHLATQEDYINQLVRDAESTHTNVGRGNKELKRASERRSEAQMVFWATVVLCVWLILWDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL98</accession>
    <name>D4DL98_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000497">
        <property type="protein sequence ID" value="EFE37375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018020.1">
        <property type="nucleotide sequence ID" value="XM_003017974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL98"/>
    <dbReference type="GeneID" id="9579147"/>
    <dbReference type="KEGG" id="tve:TRV_07972"/>
    <dbReference type="HOGENOM" id="CLU_1409748_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="193" mass="21850" checksum="15CF50FAB718BFD0" modified="2010-05-18" version="1">MNFAKGILESRKQHYKHLAKLLRPIPLQVPTKIELMPGNTIKVTLFDANHCPGSVMFLVEGDGKAILYTGDIRGKATITQSYKHDSRSVFLLTISLAESWWVQSLIRNPVLIPYTMGDRRLDTIYFDTTFATKSDIHQVFPSKAEGIRELLSKIKGYPEDTIFYLRSWTFGYEDVWLALSAALGTKVGCVDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLC8</accession>
    <name>D4DLC8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017998.1">
        <property type="nucleotide sequence ID" value="XM_003017952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLC8"/>
    <dbReference type="GeneID" id="9579126"/>
    <dbReference type="KEGG" id="tve:TRV_08002"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OrthoDB" id="5338352at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="306" mass="34385" checksum="FE4F0407BB9A1E6C" modified="2010-05-18" version="1">MSGQPNQAKANFPKCLWDLPFVNRGVSGIVFAVDELSVIKTPTGGEENAEELRVEREILERLGDHPRIVKLLYTYKDLIVLERLRYPLRFRTWELREDGRTASLDDVLKWSAQAAEGMQYFHAKGVFQVDVGLHNLLVDWDDNVKYCDFSGSSIDGSRPTVVVSPTAQHPTAVIGSPTVQTELFSLGSAIYEISTTFKAYEGLEEHELQARYARGEYPDTSRLLLGGVILKCWRGCYSNAGEVAAEIRGIQRRMKHGNDLSLSINGLMERKRSEHTRVYIRMQLFIAAAVFGAQAMFRATTINPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLD2</accession>
    <name>D4DLD2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018002.1">
        <property type="nucleotide sequence ID" value="XM_003017956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLD2"/>
    <dbReference type="GeneID" id="9579130"/>
    <dbReference type="KEGG" id="tve:TRV_08006"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="31878" checksum="5C39286FFCD0DAC2" modified="2010-05-18" version="1">MSKFGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQNLDFLNDALDPLSEEYLIIFDMPGQIELYTHVPLLPSLVQYLSRSGALNISLCAAYLLESSFVVDRPKFFAGTLSAMSAMIMLEIPHVNILSKMDQIKGVIGKKELKQFTSVDINLIEPGNEESTGRDPSSTTEVLTGSSFNRLNKAVAQLIDDFSMVSFLKLDAQDEDSISAVLSYIDDAIQYHEAQEPREPAADPEAEADME</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ22</accession>
    <name>D4CZ22_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho GTPase activator Rga</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025797.1">
        <property type="nucleotide sequence ID" value="XM_003025751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ22"/>
    <dbReference type="GeneID" id="9582040"/>
    <dbReference type="KEGG" id="tve:TRV_00059"/>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="921"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="754"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="858"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="697"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="122462" checksum="EA8B2CE5A3280483" modified="2010-05-18" version="1">MDMDASASTESPDDQDDFPIHCKGCGEILEEGKAFELAGNRWHIDCFRCHTCGAYLDSDVNLLMVGDGSLVCRNCAYSCSSCGSKIDDVAIVTGEQAFCAGCFKCRNCKKKIENLRYARTSQGIFCMDCHESLMSRRRKRTARNAAQRQKPPAPSMHLDKSLPSLPPSMVAPENNPPPPSSSDIYSDSTSEHLPPSRQEDDRAARSYSSHQATHRSDGSAGGEEFLIPVAFDPTPSEHASPHLGSPHSSMTLSDGQKDYFGRAPSNALGISADGPPVLSPTHIAYQDKRQMNPNPQQWIQETVTPPQSQTTNNAIQRTGSHSARTSMNIDSSRLSQEGSRGKDQATLGGSVHLTPSERSSNRHSVPGKDAIISQSSTFNPRKKVSNEQSNPGTISSSNQLQYPPKRGDSLESKLHHNIQRKEIPQPSQDHAEKPEGTVRSSTSSDYASVASKAVETTPPSHSNTTTAGAGAVSPSHARSVSGGVSGNVLPPDSQRQNSSGSSPGLLRYSAVGDFSLDEDMARILGDDPQAQDSFLRKVSNSVRHGRSFSDKGSRLSRDSKWPAKSPLEAGNSGNDISSPTSSGLDPKDELTWLKNELKRERQKVVEKDQKIVELEASLNATVNIKQVNTELREKRSTVIFLDAQKEIILRELEVWKEHIAAEKKNNKPLDLGKMSNSVLRDLAESLENLKNTFAPQIEDLIQKRNDLVEELSNLGKMKDKSFQEFEQLSLKNAQLAELNNQLVHQIQELYKANSNTSGGSVRQPPPNGLGIYSHNKDKPNTSLEARSTPYEAVGSSSSVTVPEEAEPATVIQGPHVVNIRKGQPKKFTWKKGQNVAKGVTKGLKGAFLYQRDGQLNENSSFVSTPQQENNGSAMPRSQTQDPSRQGFGFFGSNQKTKPTPWRGQSNGSSPGLDTTTSLFGGELEQRLEIEKAVIPSIVTRCIEEVELRGMDVEGIYRKSGGSSQVQTIREGFERSRDYDISDPDLDINAITSTLKQYFRMLPTPLVTYPVYDILIEATNVTPVSARIEIIQQALQELPRVHRDVLEFLVFHLKRVVDREKENLMTSLNIAVVFAPTILRPESLSREMTDVQKKNETIQFMVENCQDIFMGIEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ59</accession>
    <name>DPP4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl peptidase 4</fullName>
            <ecNumber>3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dipeptidyl peptidase IV</fullName>
            <shortName>DPP IV</shortName>
            <shortName>DppIV</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPP4</name>
        <name type="ORF">TRV_00096</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5"/>
    <dbReference type="EMBL" id="ACYE01000004">
        <property type="protein sequence ID" value="EFE45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025725.1">
        <property type="nucleotide sequence ID" value="XM_003025679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ59"/>
    <dbReference type="SMR" id="D4CZ59"/>
    <dbReference type="ESTHER" id="artbc-dpp4">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="D4CZ59">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="9581968"/>
    <dbReference type="KEGG" id="tve:TRV_00096"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_2_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000003">
        <property type="entry name" value="Probable dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397815" description="Probable dipeptidyl peptidase 4">
        <location>
            <begin position="19"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="753" mass="85635" checksum="02B1752AB9C6F26E" modified="2010-05-18" version="1" precursor="true">MKTSQFLSLLLLAGIAQAIVPPREPRPPTGGGNKLLTYKECVPRATISPRSTSLAWINSDEDGQYISQSDDGALILQNIVTNTNKTLVAADKVPKGYYDYWFKPDLSAVLWATNYTKQYRHSYFANYFILDIEKGSLTPLAQDQAGDIQYAQWSPMDNSIAYVRGNDLYIWNNGKTKRITENGGPDIFNGVPDWVYEEEIFGDRFALWFSPDGEYLAYLRFNETGVPTYTIPYYKNKQKIAPAYPRELEIRYPKVSAKNPTVQFHLLNIASSQETTIPVTAFPENDLVIGEVAWLSSGHDSVAYRAFNRVQDREKIVSVKVESKESKVIRERDGTDGWIDNLLSMSYIGDVNGKEYYVDISDASGWAHIYLYPVDGGKEIALTTGEWEVVAILKVDTMKKLIYFTSTKYHSTTRHVYSVSYDTKVMTPLVNDKEAAYYTASFSAKGGYYILSYQGPNVPYQELYSTKDSKKPLKTITSNDALLEKLKEYKLPKVSFFEIKLPSGETLNVKQRLPPNFNPHKKYPVLFTPYGGPGAQEVSQAWNSLDFKSYITSDPELEYVTWTVDNRGTGYKGRKFRSAVAKRLGFLEPQDQVFAAKELLKNRWADKDHIGIWGWSYGGFLTAKTLETDSGVFTFGISTAPVSDFRLYDSMYTERYMKTVELNADGCDDNVHFQNAAVLSNTLMNGGVTADKLTTQWFTDSDHGIRYDMDSTYQYKQLAKMVYDQKQRRPERPPMHQWSKRVLAALFGERAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZD0</accession>
    <name>D4CZD0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase family protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025649.1">
        <property type="nucleotide sequence ID" value="XM_003025603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZD0"/>
    <dbReference type="GeneID" id="9581888"/>
    <dbReference type="KEGG" id="tve:TRV_00172"/>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="444"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="634"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="836" mass="91865" checksum="80F5BC9F8D0B7A1E" modified="2010-05-18" version="1">MLASKLLSSAPHIATQQALLVLDLQNDFVRQHGNLFVSNTADFLSLIPDLARIFRASGEVIWVQSVFEGRRPVVNEGLGGDTVVLEDGPPVTSTPAPKGLSKKKQAAEQARQSLFSDDPEAFLSVSDKACAGRRCCLPNSSGFHFPAPILAAIDPNEDTVLVKSEYSAFETQGLLLSLRSRFVTEIFVCGSLSNASVYATAVDAVRHGLTVTLIEDCLGYRSSLRHREAMRRMADIMGANGITSRELMEGQDFAAASPVLERADSSLLTGIEEKIGTLGLSSPNYQNPDGQIATHHFIEGGADKPQDILETSQRPVDPPEEKDARKPQDGDQPIESPSPSQKQNSSQPLVCTPGDRIASGDSRILYDLAIPADSFQRLRDEVEWQKMYHMSGQVPRLVAVQGDVAQDGSIPIYRHPADESPPLSPFSKTVDKIRVVVEKELGHPLNHALIQLYRDGEDRISEHSDKTLDIVRGSNICNVSLGALRTMTLRTKADAKKSTHSSPENSRQTQRVPMPHNSLFILGEKSNMEWLHGIRPDKRPEKEKSKEEKAFNGERISLTFRHIGTFVNPISYTIWGQGALSKKKGKAGKIVHGDSPETERMIRAFGQENHQSDFDWDANYGRGFDVVNFVTTPSLTFLPGACDKPTDLRIRLALTENGIRYEIRGVKDPPSNDEADTKASPAPKGEPSLLVDSDGSHVETGSMAILQYIAETAYCRIADIAPDPDMKVDGLTLEERLNAVDELYEAWTTSSDSDVEQVAAKLSAFNSLIHGKLYINGKLFGVDDCAFWSVLREIVEAKAGSKVVEGKFPLLMGYYSRVRKRACVKQVMDEMAVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZF0</accession>
    <name>D4CZF0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000013">
        <property type="protein sequence ID" value="EFE45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025625.1">
        <property type="nucleotide sequence ID" value="XM_003025579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZF0"/>
    <dbReference type="GeneID" id="9581863"/>
    <dbReference type="KEGG" id="tve:TRV_00192"/>
    <dbReference type="HOGENOM" id="CLU_669380_0_0_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="411" mass="45310" checksum="D2B6A1DB3B9A901A" modified="2010-05-18" version="1">MLTAQLNLAATSVDPGVARHFLFCGTKLIRARRPQDPADDEAAALAMVVRTGFNTTKGALVRSMLFPKPSGFKFYQDSFRYISVMATVAAVGFIVSFVNFIRLKAQIPADILHKSTKVPSRQELLCIHVTNFNRVNVAGKLDVVCFDKTGTLTEDGLDDYGPNTAILYTMATCHSLRMIDGELIGDPLDVKMFEFTGWSYEEGSHNTAEVYEDYENISPSIARSPLNFAPPNDTGPTLEASNATELSILRIFEFVSQLRRASVVVRQPGSDGVDIFVKGAPECMKDICIPKSLPPDFSELLNYYTHRGFRVIACATKHIPQFSLRDIFSMSRADAESDLEFIGFIIFENKLKPTSKGVITELHEAGIRSVMCTGDNILTAVSVARECGFVEGAAPCFVPYFVEGKLPLRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D021</accession>
    <name>D4D021_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025425.1">
        <property type="nucleotide sequence ID" value="XM_003025379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D021"/>
    <dbReference type="GeneID" id="9581661"/>
    <dbReference type="KEGG" id="tve:TRV_00415"/>
    <dbReference type="HOGENOM" id="CLU_1422379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="191" mass="21700" checksum="77236714C60FE8B5" modified="2010-05-18" version="1">MRETVEMTVSRAEPSSSPSSFVFFVCRGWPSLSSTAFCSLLDGLVMSDARLPVVAQLGGELDHPTVFFSSAANFSGSSASSMYIFICSVFSLSLSLPPTFNPHLDLIFKRPIDCPPPRRTSFAACLCWLRLLLWVRNTNHQNKKEKKKQPEGNKNRKLAIRRRRRRRPLLSSPLLYLYILKKRERLPPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D043</accession>
    <name>D4D043_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025376.1">
        <property type="nucleotide sequence ID" value="XM_003025330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D043"/>
    <dbReference type="GeneID" id="9581611"/>
    <dbReference type="KEGG" id="tve:TRV_00437"/>
    <dbReference type="HOGENOM" id="CLU_002833_2_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="372" mass="41172" checksum="1D642EF50B780E47" modified="2010-05-18" version="1">MESAAALRRWTEVFIVMKPEDIPLGYYTHINFAFALIDPHSFRIASMDPQTGSLYQRVTALKDHQSDLQVWIAIGGWAMNDPGPTRTTFSDLAASESRQDAFFESLITFMLNNGFDGVDIDWEYPVADDRAGKPEDFKNFVTFLRRLRRRLNQTGRKFGLSITLATPKASRMHSCPSLTDVGLLDGTWDAGVKSIGSHAYAHTNLTEINMALELLWRNNINPARVVMGLGFYGRSFTMKDPNCLDPGCEFKSGAHGGECTGTPGVLSAGEIKKVISQGATIKLNTEAAAKLITWDNDQWVSWDDEETLKIKMDYANKRCLGGVMVWAIDLDDGTLIDALGAAMNKTKTEVSKGPLSFLGSDLGTVWPEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0B0</accession>
    <name>D4D0B0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025325.1">
        <property type="nucleotide sequence ID" value="XM_003025279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0B0"/>
    <dbReference type="GeneID" id="9582936"/>
    <dbReference type="KEGG" id="tve:TRV_00505"/>
    <dbReference type="HOGENOM" id="CLU_1994271_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="125" mass="14064" checksum="9B9CEEB48CA358B6" modified="2010-05-18" version="1">MIFLARRKDEKDEKDDKEGQRAEQPQDEDDAEDDGQGGGPRNETSLFSRRRPVSGCDAQRGQTDVWAHDWLTVEQVVPTRCFFFCCVSGSPLAYPEMPSRPGEFIPNFRAPSSDSQLPDDGCRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0L6</accession>
    <name>D4D0L6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000036">
        <property type="protein sequence ID" value="EFE44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025206.1">
        <property type="nucleotide sequence ID" value="XM_003025160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0L6"/>
    <dbReference type="GeneID" id="9580711"/>
    <dbReference type="KEGG" id="tve:TRV_00611"/>
    <dbReference type="HOGENOM" id="CLU_3056305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="54" mass="6174" checksum="C8039D6EDA79DFBD" modified="2010-05-18" version="1" fragment="single">SPAEEERLSHLVLLKLLSYPALSTSHHLLPPPSPGRKKERKTTEKQKNSEKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0N4</accession>
    <name>D4D0N4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000037">
        <property type="protein sequence ID" value="EFE44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025202.1">
        <property type="nucleotide sequence ID" value="XM_003025156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0N4"/>
    <dbReference type="GeneID" id="9580695"/>
    <dbReference type="KEGG" id="tve:TRV_00629"/>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="162"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="461" mass="51212" checksum="A2D75DB238A6E9F7" modified="2010-05-18" version="1">MASLNLTLIQQYLVRIPLVLVTAIRRLLQLSPVQDRVSVQMELLVTFVRSFLTLDDSVSKMAEVRLTDSTIKGYMWISNVTVPKPAEDDVLEALVKAIRHRGEGGETFDMPDVRAVEAEWTGYRKGASEDTPIPDISDADKYERLMEDVDDDMTIFYAHGGAYQLCPQHPFPAGILDALVAYLSLLSPAEGALYEAVPAKKIVFAGDSAGGGLCLGLLQTLLTLREIIPSKTIRFHGKDVPLDLPAGIATTSPWCDITRSLPSTFENAKYDYVPPPPQKPGTIFTPLPFPPDHLWPTVPPRVDLYANANMMAHPFTSPAASPKGIWKGGPPMYIAVGEELLHDDGMYMARKAHRDGVNVVFERYEGMPHCFALLAPNIPQSQRCLKGWAKFCVDAVHDRVKGYGEAQFFNHSLTKTDIRSLDDIGTLTDDEVEKLIKAGRDWRIDGEHLLQKAWKEQELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0X8</accession>
    <name>D4D0X8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_00724</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025066.1">
        <property type="nucleotide sequence ID" value="XM_003025020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0X8"/>
    <dbReference type="GeneID" id="9580578"/>
    <dbReference type="KEGG" id="tve:TRV_00724"/>
    <dbReference type="HOGENOM" id="CLU_001485_24_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="241"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118180" checksum="67B33D077DD4ACA5" modified="2010-05-18" version="1">MTSTIPQPTRLPSNPPPRSPPRSALPPIPASKTRKSMPGPGDSVKLYATSPLPSKLRTPSAVQTKSAVPSNLGISSLSPSKSSFRSPSVCLTPGSPDKAVRRTVSIASFPQPPKASRPSLSTQSSFSGNPPDSPRSVPNPRTKKKAPRIDTGAGSQLKNSKTPSLLNGSGDGKSIPNSRNSGGHASIVSPTQSRCSSAQDSYSTSATTYDDEEGTRRGRDGVDDSTGGSNRSPKGREGKGNVLVSVRVRPDLSSGEGKNSEGEWLVDGRRSLVSYRGKEGGDYFYDNVFTTHDNNAKVYDASAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTATSPGVIPLAITDIFSYIRETPHREFLLRVSYLEIYNEKIHDLLSMSASGQGNGTGAQGQQQEEIKLREDSKRGVYATPLKEEIVQSPTQLLRVIARGDHSRRTSSTQFNSRSSRSHAVVQIVVESRERAPVAGHEKRAAIAPGGVRVSTLSLIDLAGSERAAESKERRAEGAHINKSLLTLGTVIARLSVEKEGKNGDKEGKHLPYRDSKLTRLLQPALSGNSLVSILCTIQVGSGGTAASSQSHTNETMNTLKFAARAKNNIVSHAKRAEESLGSGTGDAGSRVLLERYRMEIQSLRRQLENQAKAETPTTTSETESKEEERAREKEAALRHEEQMLEMQLARTALKERIEHLNRLILCSKSTGVNASLARFSSQTSPGSVDIRSLRSSVSHSTLGAGTALNRSTSLASMKSSASAGHANAVAPFAHHQDDDDEMIGEFADGMASLQVQVNALQADLADKNRYISTLERRLLQARRSSHSRVSMGLNHHHHLKSCSTTSSNNDSDLASLLREKDMEIADLRLQLDDKDRMVAALRSAARQRDMAHLTGGSTNATNRADAAPTPPPLHPPPPVGADYKIMGINNAILPHHNSHSHNNHHSETNSLFSNSGVGSGSVLGRVSPNLLPPVKLSAEDRDRKRKSVDEMSRMLDEMIQDRVESGHLIKTSKGHMRVSSAGVSPKSNDGTPQKNSRMSRMSTGTVADLSSSNGLFSDVTYSHSRTKDSISTNSDNQLRRDEEPSEQNATNMDTSVDKPAPRPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1A4</accession>
    <name>D4D1A4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_00852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024933.1">
        <property type="nucleotide sequence ID" value="XM_003024887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1A4"/>
    <dbReference type="GeneID" id="9580424"/>
    <dbReference type="KEGG" id="tve:TRV_00852"/>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="216" mass="24206" checksum="5B48DF4325633F6C" modified="2010-05-18" version="1">MDSPTRLTILISGSGTNLQAVIDAIDAKTLPATVVRVLSNRKDAYGLERAKKAGIPTVYHNLLTYKKKHPNTEEGVKKAREEYDTELARIVLDDKPDLVVCLGFMYVLSKKFLDPMAKAGLDTINLHPALPGAFNGTHAIERAQEAWLEGKIDKTGVMIHKVIAEVDMGEPILIREIPFIKGVDEDLEALKERIHKIEWEVVIEGINIMIKRMEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1B0</accession>
    <name>D4D1B0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024939.1">
        <property type="nucleotide sequence ID" value="XM_003024893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1B0"/>
    <dbReference type="GeneID" id="9580430"/>
    <dbReference type="KEGG" id="tve:TRV_00858"/>
    <dbReference type="HOGENOM" id="CLU_021696_0_0_1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="233"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="576" mass="64410" checksum="928277E91F0C8A89" modified="2010-05-18" version="1">MSLQKNETCEPDLLKRRRECSFMIRIDPYNPIRHFQRGLTYQALGFPDLAAADAYRALTLFDSVIDPDTSEYPARKRVDLESFSDLSSLEVSDGSGGNTEDYGNCLDVESPAFEPLSDKEYTEHIFEVYELLVKSLAQCGCLRDAYDMCVQAMNLPTDGVKGKVRNTELPLLLNKIKEAAISTNVNSTGFDPMTLPAQGHARRSLYPWNTHEPDRNKPEIVRYLNERLARVAPKCEVRTTTLPSLHESVVNGNLREDITFEGGNVSIQLGLFAKEDIAPGEILLHESSMLTATNRLHDDICDACNGRLPELSSPEPPVACEDCHDTIFCSQTCHDLAQELYHTAMCGQDGLESIGKDVPDPKDKADYLYLLLLERSIAMAATQDIHPLDLPEVKYIWGDFSSLDGKGDDIFDTTFTKRPASATLPFSFQLNIVQPMRILDEMGIDPFKSLDRYDTWVLNTLYAKFRGTASGRLSTWDGGPEVCAVHPLWCLANHSCDPNVRWEWGGEITFTARTDEGRVKWGPESRSSKGGISKGEEILNHYCDVSLPVKKRREWAMGALGGACLCERCIWEAAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D3</accession>
    <name>D4D1D3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024962.1">
        <property type="nucleotide sequence ID" value="XM_003024916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D3"/>
    <dbReference type="GeneID" id="9580454"/>
    <dbReference type="KEGG" id="tve:TRV_00883"/>
    <dbReference type="HOGENOM" id="CLU_010668_0_1_1"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="6">
        <location>
            <begin position="418"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="906"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="945"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119356" checksum="045A615D9FCC0591" modified="2010-05-18" version="1">MDAAAAACWAVYLDDRVDCERWIDRDGEQLHESAELAANLARILAICRQGNTPYSSSCYSCYSLLLILTGTVYVCNSGKSFATKIAELTDAGREEGDPDAAIVPVLAFIDIAVSGDAESSHVRRSSLNLTPLSSPPSQPQPPHQHQHQHQHLPQQAQGQPSAVSPSTSRRSLAFSSESEELFGLHLLSRFSADIQARETPHAIIPIAILRNVRPQPSPFSSSAHVLRSGKNVEPATKPSSRRPDDRQISRCLDAGAIDVLVSPIDQSRVQGLLIHAYRIRRAAQKENSRFMAASGQKIRKYSWVGVSSTAEDERPYAYLREAMVSKLMKRICNPEEALDDSLISDVCVSDERKEEVKAAIAEWHFCAHDFTDDELCYASCLMFEHTLTVPDLEHWRISSGAIPPFPLGSEPRSSCAGMSCLVTPFDALALLVIALGHDVGHPGVNNMFLVKLNAPLAQLYNDRSVLEAFHCAAYSQILRRHWPAVFQDTEMRTLMISSILATDMGIHNHFIDELGKLRGRYAADGRKVDSWIEKDIRDYRVLLCALIIKCADISNVARPFKVAEQWTDVLQLEFANQGEMEVNIGIATSLFGGPPELGNFIKKAKGQVGFMDIFGLPLFDGVTDILPDLAFAANTIRSNRFIWAKLMEHEEVLAEHRARNCSTPRCQGTDPSWEECRKRLIEEGPASMGYTIQHRSPPHSPIRSPPQLDGEADTTNIQATTTTTAITTPAAAGPTTNVPVIINGIHHANRQSQRSAGRSSVQNTARTIDSGSGCSGSGGGVRTQSTSTYTNNTLITPLSSTTQASSVISAGSSFEEKDGTCQLHQRISLNPNAMHHHHVRRCDQAKPDDVALAGAASTTTASSYTSSIAQNENEDEHDHDGGHQNMYADENLPSPVNALPSTTDGTSSHQHPQSQSQTQTWYERATNSKAGERRSKFITGLFEKASSNNNNNPAATTNSTKGNHPAGLTYSKSAQSTPTVHNNSHNHHHNQHTRGRRGGPTSHPRSTPSSPPLPPSTLPFDSDDGNNDPLSSLSPNHATMPLPRRRSRLRLAFWRRSKHHGQGPGHPHSPPQSDSAPSTTASASSMMSASDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1H2</accession>
    <name>D4D1H2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024917.1">
        <property type="nucleotide sequence ID" value="XM_003024871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1H2"/>
    <dbReference type="GeneID" id="9580408"/>
    <dbReference type="KEGG" id="tve:TRV_00922"/>
    <dbReference type="HOGENOM" id="CLU_026885_1_0_1"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="456" mass="49795" checksum="6B7CED699C573D4F" modified="2010-05-18" version="1">MIASTQKSTIMFDNTTTKEKATVHSSKSSDSWSPTSWTTKKTIIQEVQYQDPKVLQDVCNTIANLPPLITPEEIEAARSQFAEAALGKAFVLQGGDCAESFHDVRPHIVNQKVRLLEEQSHILSQGLNRPVATVGRIAGQYAKPRSSLWETLPDGTEVPTFRGHNVNGPELSERQPDPHRLLLGYFHSQATLNLIRGPDALSTPPMGSFPSTPADGEEGATKRANGGTIYTSHEALHLPLESASTDGRYNTSASFIWIGERTRQLDGGHVEYVRGLRNPIGIKVGPTMTGETLVELLNCICPNAQDPDHIGRVTIITRFGADKVETVLPPLIQAVHQSGHRPLWMCDPCHGNTCTASSGHKTRHISSILREATTCYRVHRENGSTLGGLHLEQTGEFVTECVDGSDMGSEEKLGTNYRSLCDPRLSYLQGLTVVRGFVDFAQHIDAKYQTAAGNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1H5</accession>
    <name>D4D1H5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024920.1">
        <property type="nucleotide sequence ID" value="XM_003024874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1H5"/>
    <dbReference type="GeneID" id="9580411"/>
    <dbReference type="KEGG" id="tve:TRV_00925"/>
    <dbReference type="HOGENOM" id="CLU_052060_1_0_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="260" mass="28376" checksum="771C8936ADCFE67E" modified="2010-05-18" version="1">MVVYIVYGFRWSRVGTLTAPGIRPHIVINDLLDAASDYIQEPRTAKEVIQSFERIDANIPSHLPNLALIEQYDSEDTSISALSQPYAFVCSKVVPIGDGSEPQFNFFLSLDLEDFISKGPGLSAAELATFANLREVLAPGEKVGWWIVYNGNPERFSADKTGSDSDTTEGDGEPEEAGHRSGPPVCVPIKSIIIACTHTAANNPVSPLDLSNLRLFPQNRGLTFQRGPKSSSLRTNLTSFPWSGFDAPTVDSSVCYPKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L4</accession>
    <name>D4D1L4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox and C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024890.1">
        <property type="nucleotide sequence ID" value="XM_003024844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L4"/>
    <dbReference type="GeneID" id="9580381"/>
    <dbReference type="KEGG" id="tve:TRV_00965"/>
    <dbReference type="HOGENOM" id="CLU_008497_1_1_1"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="889" mass="98515" checksum="BA0963AB22D129EC" modified="2010-05-18" version="1">MEYFDFDEAARQNGDIFRYTEVADQDRCDPILAGFDNAAPPNTTPSFSQPSDAQQPSSLDGAYPMHRVKDPCYFCRCMGLDCVVAQRGVMQNACTCCIALYRKCSFTRPLSKENHIDTQQSESEASSAKGPPSPSQPPNPGNISNLPKDIEQQPRKSGVRFSLKAVKVLKSWISEHASHPYPTDAEKDELKEKTGLNRSQISSWLANARRRGKVRPPPRCTSPYPGAVTIPGKRLPPGVDISELNPLERWKHSPPENEAASARDIIQAMATSSFISHLESDFPHLKSHSRHTDSSNDDSYSNKLTAHSISGYSADTNKSSLSEMSFASAFSHRSRGSWNSTENRERRRRRHKSAAAPNPFQKSRVARIFQCTFCTDSFPTKYDWQRHEKSLHLALDKWTCAPNGGIITNSSGELVCAFCNHPNPDEDHLETHNFSTCQEKSVQERTFYRKDHLNQHLRLMHGVKLAPWMDAWKSTTTKIKSRCGFCSATFNTWKERVDHLAAHFKAGTEISQWRGDWGFESHIEECVENSMPPYLIGQERNTLDPWVASKAFNLAKYGRNFSKEHKVAPSEDTEMSALGMPFRTDASCFRRLEKELSAYIARLFDEGITPTDKLLQSKARLIVYGSDDTWNQTCADNPIWLKVLKRNNGLEDSSDTEDIKLEDLGMQPPFAADGGLRQAPAHSSRPRQALSGTLSPPSGFESTTASNPASIADSTRNNSDFCFKGGGGSRSSAHNYTPSPGSHSPHNLNFPSPMSVHPHGVNNESIAVDPLLEMGFDAEFLQQLNDGYGDLGRVIDGLELQGLGYTGATLHNGTFNVQKNNNNNNNTYDNVSTTDSAPVTPHSGIAMTSPEALYTVVSSGGSVEPVYIPGAFDSLSYNFQQTTDGYRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1N1</accession>
    <name>D4D1N1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024848.1">
        <property type="nucleotide sequence ID" value="XM_003024802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1N1"/>
    <dbReference type="GeneID" id="9580339"/>
    <dbReference type="KEGG" id="tve:TRV_01013"/>
    <dbReference type="HOGENOM" id="CLU_1462359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="185" mass="20721" checksum="D8AFC38602FDDE78" modified="2010-05-18" version="1">MGGTHEHQAIVCRVTYEMAARAREREREREMREQTKTATAKRMRGSRGRLEDILSGGLADIKSIQPLQHRDQYLHQQLPIDTPICSRRSIRQRTIDQSLRPPPLLLLALLVFLSPFPTNGILISGVLLCASVESENSSPPSLSLCPGWLLIKNLLPVEILLLLDGQKSKEEAKSHKNFAILPSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Y3</accession>
    <name>D4D1Y3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024736.1">
        <property type="nucleotide sequence ID" value="XM_003024690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Y3"/>
    <dbReference type="GeneID" id="9580226"/>
    <dbReference type="KEGG" id="tve:TRV_01085"/>
    <dbReference type="HOGENOM" id="CLU_1239860_0_0_1"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043936">
        <property type="term" value="P:asexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055254" description="Autophagy-related protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="216" mass="24590" checksum="024EB9A20EE7FC8C" modified="2010-05-18" version="1">MSHFLSSSLSLRLLFSSTSASQPTKTASFVHELSEFSCLCQQMHHLSLALFPLFLSPAIINFCLLHLRCLSCQSTALFANTATTQQLTYKKSATMRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGSFPELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D228</accession>
    <name>D4D228_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024723.1">
        <property type="nucleotide sequence ID" value="XM_003024677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D228"/>
    <dbReference type="ESTHER" id="trivh-d4d228">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9580213"/>
    <dbReference type="KEGG" id="tve:TRV_01130"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_1_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="35822" checksum="478E3EFBC0E601CD" modified="2010-05-18" version="1">MSNLPTLVFIPGAWHKPTCFEKITSILSERNFKCVLVTLPSTQGSPEATFKDDLDAARTAISEETTQGHNVVVLAHSYGGMVGNSAIKGFTRPQDSPTDQDQQPSGPGYIIGLILIASGFTFTSLAFMDPFLGRPPPLWRVNKETGFAELVASPREAFYHDVPADEAEYWCSQLQPQSLKALFEGGEHSYSGWLDIPCWYIGTAEDRGLPLFIQRMQAGMARNMGASVECRELRASHSPFLSHPKDTARLILEAIGQFTGNPVGNLPSLDECHAMMPVPKVELLQPLTWYKFGVPLAFGHLLGRCVVLFNWARRVLGTMGHQKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2H2</accession>
    <name>D4D2H2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000071">
        <property type="protein sequence ID" value="EFE43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024565.1">
        <property type="nucleotide sequence ID" value="XM_003024519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2H2"/>
    <dbReference type="GeneID" id="9579889"/>
    <dbReference type="KEGG" id="tve:TRV_01277"/>
    <dbReference type="HOGENOM" id="CLU_1157107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="27496" checksum="9389C929342E11C9" modified="2010-05-18" version="1">MKETRDAQREIRKIQWGEKRERSTEEAVSVSQAKEKAELFFSPSSWMEAEGGAMSQIDFAGLAVYVAAAAYLFVIARSSLSISLEWERIFGLEYHDGLTREQSPLLLRRRHQLNREESMRDDQAKRSPIVTYQHPLLTARRRHPAVMQGVVFLFFGWLVGWVDLCRSTLEFMSRQQQEGCIKHLFAAGKGSIILLITHLATFGAPFWSYRLYSVHNTLGNPAAIKRQILIPHTDSKSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L6</accession>
    <name>D4D2L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024491.1">
        <property type="nucleotide sequence ID" value="XM_003024445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L6"/>
    <dbReference type="GeneID" id="9579713"/>
    <dbReference type="KEGG" id="tve:TRV_01321"/>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="444" mass="48649" checksum="7DD574062816DC4B" modified="2010-05-18" version="1">MLDMLVSSQQQAAEQASEGSSCPHQQHPDSEYPAIRAKHSIFKARTLSKQCSSPTATMLIQGTFICALVANTIASSIPSSFLLPEPSGPFKVQREILELTDWSRKDINSTLPRRLMVSRFNPIPEKHCIRTEDVPTFPPASAKLEDAILQAASGGHWVDGLLAASRIRVCADVKKGYQTDSHGDNHGFPILLFSPGGNTTRLVYSSIAQTISSAGYTVITMDHPHDTDIVEFLNGDIITGGEVTFSNPSVLPFWNDVRVQDTLFVLNQALKTSPHARIGMLGHSFGGSAVLSSMVKDGRISAGINFDGGLWGDAVNTGLGGRKKPQPYLQWGAYTHNRHNDTSWETLWKAMERLHPHAWKKELGIPEGRHNTFSDFPAIIDAGGVRDVIDKASIDVLVGDIPAARSLEFIKAYVHDFFQFSLFGKDEGLLRGPSSKYPEVVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Q4</accession>
    <name>D4D2Q4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024529.1">
        <property type="nucleotide sequence ID" value="XM_003024483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Q4"/>
    <dbReference type="GeneID" id="9579752"/>
    <dbReference type="KEGG" id="tve:TRV_01360"/>
    <dbReference type="HOGENOM" id="CLU_033452_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="62599" checksum="ED25F89DC4AB996F" modified="2010-05-18" version="1">MNDSRQTGHEGDTAASTVATEPESGNNYSFLIHSNKTLTQDLPPKVDSKVYIRQRRRRTRYVSWLYSPCEGYGTNPETGSPEDHAILEAEYRLNPKPDKATRASIVSRVSLGDKEVQIWFQNRRQNDRRKSKPLHPNELSPNTQEPENSQKTVDASPPNTQNGNLNSNADDSYGNTLGTPSQSFSNCQCEHNIASSQLESSQTSITSAKSQENQCRFCSAISEPRLRAQLSSGKRKRADSGISGLEVGELENGRRSFGSTNSPSLRLSLSFDGEAVVRGEDEKTPSPPKIRDSLRIAFSADGEAVVRTAGEPSPSPSRNRTSTPLSLQSRLRSLRRTSSAVSFGSKSPDAADIFGRSRDLRRWELYCDTDARSALSSPKLGTGPTPDRSGSARFSCRRVSNANARILSPCANLPNSLLPASPPQKRKKLSRAVSSLGRLETEPSLETVSTAKLNSSHGNRNQKMKPKTDFHNGDSDKENWLPGTQNVGPRRRRLHPTAHPQNRVLQTSGDARREGNRIIGRGMTSPRKDHDKNKDTGLTGKPSLPSTSSNQEEDLDCIQGLLSLSQGAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2Q6</accession>
    <name>D4D2Q6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024531.1">
        <property type="nucleotide sequence ID" value="XM_003024485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2Q6"/>
    <dbReference type="GeneID" id="9579754"/>
    <dbReference type="KEGG" id="tve:TRV_01362"/>
    <dbReference type="HOGENOM" id="CLU_011075_0_1_1"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="773" mass="86074" checksum="EF68B8B6803D40C2" modified="2010-05-18" version="1" fragment="single">DKPKQSKSRNGCVTCKAKRLKCDETKPTCLQCQKRNVPCGGYKKSYKWLSFEESSYTGKSKPKTQRSDTEERESQCVRQYKCRFINVTAEDMPRAPPAVEAPPSASGSCASFDSRVTPLLEGLDIQGKASSGPETASGIQLQQSLVARQEAVPFPQSSGAFTPTFTSETQPFTSRSHTPLADSEDDNAEGVIRQDIPGDLITLKRKRPGSLSQIHSIPIPSPINFAADSAEMLLLRFDRRTCGILSIKDGVAENPWRTAVAPLIRDTPALYHAVCAMAAFHSTKENASFKYLGMDHMRQSVRTLAVDIESMNIDAALATTLALAFADTWDTHVSTGVHHLRGAKVLFDRAVARHTHMPLSPNDQSRLMFLYNGWMYIAVIAQLTSREDTGFDQIPFPPIFTPQVHEVDPLLGCAASLFPLIGRVAVLVQNVRKVPMNSVAIVSQAMELKTLIEQWAPPRYFKPPEDPTSNIQDSFQTAQAYRWAILLHLHLAVPEIPSESTSELANRILVTLATIPLGSRTLVVQIFPLLVASCETDSEEDRNWARIRWAEMQQRMAIGNIDRCIEVVCEVWKRRDARKAAMMNHQSDIYSLPLDTPVSGACSRHDSVIEPLVFAGRQDSRVFTADDINAAASTTLPETFNQTPSPSPTVSLASSRGDGSSGLCRIFPEYERTVRGNLHWLSVMGDWGWEGSYFMSYNGGYLNVFFFLTLEYSPTWLSLHCSNHHSPSTFDFKPKNIFAFTRISMKEHHGYPTLGQKTPSYPNYHTIERLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D353</accession>
    <name>D4D353_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024312.1">
        <property type="nucleotide sequence ID" value="XM_003024266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D353"/>
    <dbReference type="GeneID" id="9579470"/>
    <dbReference type="KEGG" id="tve:TRV_01510"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="517" mass="55959" checksum="96A95E8CB8BBC3F2" modified="2010-05-18" version="1">MAASSSRDDPKQPGDYDDTLTDTSSNEELLATIPKGTMDPVYEAKALLLNKAILDIGMGWYQWQLFIVIGFGWASDNMWPIITSLIFTPVKNEFMPSKAPLLTLAQNLGLLVGAVFWGFGCDIYGRKWAFNLTIGITAVFGLAAAGSPSFSAIGAFAALWSIGVGGNLPVDSAIFLEFLPSTHQYLLTILSIDWALAQVLANLVAWPLLGNYSCQENSECTRSANMGWRYFLIAMGGLSMVMFLLRFTCFTIFESPKYLMGKGQDEEAVRVVHEVARRNGKVSTLTVEDLARIGPPIRSNAKVAVQRKLSKFDFKHVNALFGSPTLAFSTSVIIGVWAFIGLGFPLYNAFLPFIQASRGAHFGDSSTYITYRNSLIIAVLGIPGSLVGGALVEIPYIGRKGALSLSTAMTGVFLFCSTTARTSDALLGWNCAYNFMSNIMYAVLYAYTPEIFPTKDRGTGNALTAAANRIFGVMAPIIAMFANLQTAAPVYVSGALFIAAGILVLFQPFESRGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3B8</accession>
    <name>D4D3B8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024227.1">
        <property type="nucleotide sequence ID" value="XM_003024181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3B8"/>
    <dbReference type="GeneID" id="9579265"/>
    <dbReference type="KEGG" id="tve:TRV_01577"/>
    <dbReference type="HOGENOM" id="CLU_014831_4_0_1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="287"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="442"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="585" mass="64932" checksum="42406AADD3C76944" modified="2010-05-18" version="1">MAETGPKLGRTRASAARMAKADTLDAGMDRKPISPPASNSPPPSHGIKSKSAHSTARSTRQRSRTGSEPVNPDALARALQDFEDAGRQRESTPGSSPSRKRQRVYGDRFIPNREGQDLQAGFSLLHEDGCPSTPSKTKKKSTHGEIHSQKTEEANRTYSRVLRNEFFGSTIPQPDIHSLSPNPLPGRSSASRDFASNTPQSHKLAMSLPPASITPSTPSKNLLSYTSPRNASGNPTPSRTPRSQHGPNFDARSELYSLSPIRFDSQQILQSLRKQPRYVNKVPFKVLDAPDLTDDFYLNLVDWGSSNILGVGLGSAVYMWDSINGHVTKLCQLDDDTVTSVNWIQRIWDAEHCRRLRTMTGHTLRVGALAWNDHILTSGSRDRLIFHRDVRSPDQYLRRLAGHKQEVCGLKWNTDDGQLASGGNDNKLIVWDKLNEAPLYRFTDHTAAVKAIAWSPHQHSLLASGGGTADRTIKFWNTSTGSLIKEVDTGSQVCNLAWSKNSDEIVSTHGYSQNQIVVWKYPRMEQVVSLTGHTFRVLYLAMSPDGQTVVTGAGDETLRFWKIFNKKGLKQQDRESKLASYTTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H8</accession>
    <name>D4D3H8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024205.1">
        <property type="nucleotide sequence ID" value="XM_003024159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H8"/>
    <dbReference type="GeneID" id="9579243"/>
    <dbReference type="KEGG" id="tve:TRV_01638"/>
    <dbReference type="HOGENOM" id="CLU_1714644_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="153" mass="16548" checksum="41CAC754A4B5D5EE" modified="2010-05-18" version="1">MSSSMNLARKSLLARSAPSSPLVSSIPSLSSPGRCSIPALSRASHSHTAHRPASKSNNTQLDPRWLSNIKRRIGKCIAFGMKQDLVPAAGGVLEEIARNWRELVAGSEGFLTGEKYCGLHRHNVVWGEMVSSTALSSTFFVFYPPSPFHVTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Z3</accession>
    <name>D4D3Z3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024039.1">
        <property type="nucleotide sequence ID" value="XM_003023993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Z3"/>
    <dbReference type="GeneID" id="9582732"/>
    <dbReference type="KEGG" id="tve:TRV_01806"/>
    <dbReference type="HOGENOM" id="CLU_130036_0_0_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="177" mass="20496" checksum="BC0545607CC8AF77" modified="2010-05-18" version="1">MDMDIGCRRDIRPLLDFPAWVPRTWPYGVSNDLMASSPGHPLMIKAALSLYDHNWWYVSKYVTVFFTTGPMFFSGIILSWFEILKTGAKDDIASFKGPHGLAILPSQLYDTTEYTFFSHFPGSTWHGNDVAVLSWLYHYLWIFFLVAFALMIVSVVLGPTRRAKRRMPRFMMKQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D420</accession>
    <name>D4D420_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024066.1">
        <property type="nucleotide sequence ID" value="XM_003024020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D420"/>
    <dbReference type="GeneID" id="9582759"/>
    <dbReference type="KEGG" id="tve:TRV_01833"/>
    <dbReference type="HOGENOM" id="CLU_035142_2_0_1"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF5">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="193"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="543" mass="61787" checksum="E354510A18C2AB2B" modified="2010-05-18" version="1">MVVNTEAGRPRVNMKGMDQYSPMHCQAQAQGVEEYPSWNTMPVSERSDIKFWCDLKNLVHSANIGGLDKAHDGRTTNALKVPYPHFALVGIDWSGQLKFHSSLLEKFNGPVFTSEFKHWFERATGVKALDRSPIFAGEDSYQGRQWPMAQEVDVFPNPAFPKKRRREMIHHQAPIEAEEQVNEMEAVEMVPLEIGNEEKIEAYYESAFRAFQQINCRQVAKAYIKIIEPRKQVKHPYNGGRGAPGEKGDPEKTKPDWWPAGVIHREPDHLKKPERIRLLVHIFRKLGKTHGITADKLEEAGRDAQRQIKPRERLDILDEIYKVRRAEECYERGEADANAVVYVVNRDANAKTERDSEAMSDAGQNSALTEDSRKTMEAKYSTLSPSHVPKRQSLVRDHKPPHLFRAPNLADFSNMESKPPADQTIEYFSQPEFATSPVDEHINNTIRDSHHWSSFQQPLYSPVEYNTNHLVPQQLLAPPSMVTSEAPNSALQPTHGLPIPEPHGSRHQSFDYISMDNNPFNAGPMTHQLLPQSSQESRPSCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D469</accession>
    <name>D4D469_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_01883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023942.1">
        <property type="nucleotide sequence ID" value="XM_003023896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D469"/>
    <dbReference type="GeneID" id="9582635"/>
    <dbReference type="KEGG" id="tve:TRV_01883"/>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="424" mass="47885" checksum="98E259E2D7C8D402" modified="2010-05-18" version="1">MPSACTQPVGCHEVRYIPLSYNHADSQASALRLVLTLNPHWKDAQGRIEFVRFTDGITNTLLKIILRAPGLSEEEIDKEAVLMRAYGNNSEIIIDRERETKSHALLASRGLAPPLLARFANGLLYRFVRGQAASPDDLTKPAIWRGVARRLGQWHAALPISDAPSDAPSPGTRDGDSLSLGSSDSEIKPVQESTAVEDDITPINTRFEGPNLWATLQNWILALPKSTDQERTRRKNLQKEYERILSEFDDGSGLGEEGMVFAHCDLLSANVIIQPRPKESTLADGAAETVDFIDYEYAIPSPAAFELANHFAEWAGYDCDFSRLPTRSIRRSFLEEYIDSFAQHRELPESKQKTVDSLFADVDRYRGLPGFYWYATISRIDFDYASYAEQRLAEYWAWRHEQDGSRSKAGEKMPLREQRWAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A8</accession>
    <name>D4D4A8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000102">
        <property type="protein sequence ID" value="EFE43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023935.1">
        <property type="nucleotide sequence ID" value="XM_003023889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A8"/>
    <dbReference type="GeneID" id="9582627"/>
    <dbReference type="KEGG" id="tve:TRV_01923"/>
    <dbReference type="HOGENOM" id="CLU_049057_0_1_1"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="209"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="42172" checksum="5C717CE8C1B5767F" modified="2010-05-18" version="1">MPPRIPVLPARSALSLVRATPVHDTIHQTTRKFGNISLRSSKCNTPLPHRSLKGACAYRMSSTSSGGSGKQNDGGVGEQPLGPNQDQLPHVSEEAAATAQIMGKKCGEVGGPELEQGTPVADILKRDKDALKNMPKVLRDEAAASQNGSGSKRSFSTSARLHQGEVKGNSPEDPSAATVANMLAASNRGESVDVEKGIPEGFKYEPPTLPLPPNERFDRRYEPLVEQFTKLIMKHGKLSLAQKHMAKILEYLRTAPAPLIDPSKPFLPGPPSPQLPLNPILYLTLAVDSIAPLFRIRQIRGIAGGGAALPIPSPLAQRQRRREAITWILEAAEKRRDNQLSHRIANEIIAIAEGKSSVWLKRAAIHKQATVSRANIRRASQQRRGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4J0</accession>
    <name>D4D4J0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023810.1">
        <property type="nucleotide sequence ID" value="XM_003023764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4J0"/>
    <dbReference type="GeneID" id="9582383"/>
    <dbReference type="KEGG" id="tve:TRV_02007"/>
    <dbReference type="HOGENOM" id="CLU_2428652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="91" mass="9756" checksum="08CD1BAD13D39020" modified="2010-05-18" version="1">MEVEAAETAEKKKKQSRNRNAPRDEEDDARHGCCSRTVSSPTRGRHLPSGTPSCAPGAAATASLSLPVTVHRLADSGLQKETRKSNEKAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4K6</accession>
    <name>D4D4K6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023826.1">
        <property type="nucleotide sequence ID" value="XM_003023780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4K6"/>
    <dbReference type="GeneID" id="9582401"/>
    <dbReference type="KEGG" id="tve:TRV_02023"/>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="649" mass="71158" checksum="3862D1D3FBFC53FE" modified="2010-05-18" version="1">MAPSAVNEAASTPSELPDEVNKPPEGVILPPKDIKDRVREKEKNNTKFCFLNPNDAYAPFYAWRLSEIKAGRGTDVSAGRVGEAAPAKKEEESNAPKPPPEFQFSARMPNINALDLEVVKLTALFVAKRGKSFMTSLSQRETRNFQFDFLRPQHSLYQFFTRLVDQYRELLQVEGRESAVTEEQRLADLRENVTNKYNVLGRAKQRAEWVKYQEMQKLQKEEEEEEEKVAYAQIDWHDFVVVETVLFTEADDQSELPPPTSLNDLQTASLEQKAMISLQPHDRRIEEAMPTEDDSTTYYNATSDISHQPSLPVLQPQRPVSTGPIQPQAPSPSPFPSTAVTSASLSPAPMPATASPTPPAPPAAPVPAAAIPDQHPARDRVRANPSPSPVPGQPPMRIRSDYVPRAQAKHLSNANQPTSICPNCRQQIPIAEMEQHMRIELQDPRWKEQRAKAEARFASTNLSTVDVANNLKRLASQRSDVFDPMLSGVAGSSTATNEEDEEGRRKRVAVGPNGVPVNMNVPVQQRSFSQPMPTHPQPQMHVHAPGTVPGLPPGAPGTIPLPPGVAPPGMAPAPTPSPGVSVGAGISRPSSTSTGTSTNKPPAMRELPQPPIQKPPPVQPQAAPEEAKPDTPPVDINEQIRKIHEKMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4L6</accession>
    <name>D4D4L6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023836.1">
        <property type="nucleotide sequence ID" value="XM_003023790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4L6"/>
    <dbReference type="GeneID" id="9582411"/>
    <dbReference type="KEGG" id="tve:TRV_02033"/>
    <dbReference type="HOGENOM" id="CLU_024001_0_0_1"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="261"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="336" mass="37104" checksum="C00E182AAF889A10" modified="2010-05-18" version="1">MDILKNLGKVLAPISKTVSSSPPTEPEPQPEPPVDEIAELDKEPPIPPPRLSLPLNEMALDQDDNSPPIPPPRLSVLPDDEDVTRGSIELPRRERSGRDLARLSRVSFASNRFSDHYGDTTNIEDPEDGLDFRVGQEDDFDEDLDNTTGQPMLDAGGETEDLGRFNFDFAFPTPETPHTMPIENENEQDTFELESVPPEFGGPDSPSSGSDFGTGGFEPAMDDVPSNRGTPEPIEQEAEEVEMEQEDQPEPPQKKQKVSKHGIPVPSLPAGVVKKLAMRFARSGNKKTRITKDTMAAIQQATDWFFEQASGDLSTYSKHSGRKTIDETDVIALMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4X0</accession>
    <name>D4D4X0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">short-chain 2-methylacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="11">1.3.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_02137</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="11"/>
    <dbReference type="EMBL" id="ACYE01000113">
        <property type="protein sequence ID" value="EFE43132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023750.1">
        <property type="nucleotide sequence ID" value="XM_003023704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4X0"/>
    <dbReference type="GeneID" id="9582285"/>
    <dbReference type="KEGG" id="tve:TRV_02137"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="310"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE43132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="427" mass="46513" checksum="1F5D9F1A3C3AB0B3" modified="2010-05-18" version="1">MLVVISQLRSRAFSATPLRRDADLTPTPITYLSETESMMAESVSKFAVEEIGPKVRDMDEAETMDPAVVEQLFEQGLMGIEIPEEYGGAGMNFTSAIIGIEELARVDPSVSVMVDVHNTLVNTAVLKYGSAAIKKRWLPRLATDTVGSFCLSEPVSGSDAFALQTKAEKTSSGYKLNGSKMWITNSMEAGFFIVFANLDPSKGYKGITAFVVEKDMPGFSIAKKEKKLGIRASSTCVLNFDDVEVPKENLLGEEGQGYKYAISLLNEGRIGIAAQMTGLALGAWENAAGYFFSPELTTFSTNCDNSYIWNDRKQFGQLIGTFQGMQHQVAQSYTEIAAARALVFNAARKKEAGQDFVQDAAMAKLYASQVAGRVSGLAVEWMGGMGFVREGIAEKMFRDSKIGAIYEGTSNIQLQTIAKSLQKTYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4Z6</accession>
    <name>D4D4Z6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023657.1">
        <property type="nucleotide sequence ID" value="XM_003023611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4Z6"/>
    <dbReference type="GeneID" id="9582243"/>
    <dbReference type="KEGG" id="tve:TRV_02164"/>
    <dbReference type="HOGENOM" id="CLU_2067140_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055333" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13209" checksum="99C11132F26FEB88" modified="2010-05-18" version="1" fragment="single">VAFLAAFSCLSLPLSASLCLSLFASFSLPHQPQEKKKKKQVELCGSHGVTSHAWLTLLLRPLLTIFPRQPPLYYPLSSLFSSHPMRRFVSRSLPSCRRLVSSFSPLSFVALNTESSAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D547</accession>
    <name>D4D547_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023642.1">
        <property type="nucleotide sequence ID" value="XM_003023596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D547"/>
    <dbReference type="GeneID" id="9582188"/>
    <dbReference type="KEGG" id="tve:TRV_02217"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="556" mass="60291" checksum="651FAE95AD045A6B" modified="2010-05-18" version="1">MDEVTGQQTAGSINQTKKTSWFGNVAKNPFIFGVALFSTLGGFLFGYDQGVVSGVLTMESFGAKFPRVYNDSGFKGWFVSTLLLGRKMCVITAVVVFVVGSAIQAGAVNIPMLFAGRAIAGFSVGQLTMVVPLYISEVSLPDIRGGLVVLQQLSITIGILVSYWLDYGTNYIGGTRCAPGIEYTGGTVEKPVFDPYKDVGPNGCDGQSDASWRVPLAFQILPALVLGVGTLFFPDSPRWLFMKDREEEGRKSLATLRQKPIDHPSIETEFLEIKASVILENTFAKEKFANLSGVKLHAAQVGFPQKQIVNSPSHANVLYSTIHFLALGLGSGDLQLDVPLCFSSSSWGAMSSLLATGVYGIINCISTLPALFWIDRLGRRMLLMCGAAGTFISLVIVGAIIGAYGSNFKAHAAAGWVGVVFIYLYDVNFSYSFAPIGWVLPSEIFHLSIRSKAISITTSTTWMCNFIIGLVTPGMLDKIGWGTYIFFAAFCLIAFVFTYLFVPETRGKTLEEMDSVFGDTEAHEEQKRIMQIEASLRGTAIDDSDAVKAKVLEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5E6</accession>
    <name>D4D5E6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinol-cytochrome-c reductase cytochrome c1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023569.1">
        <property type="nucleotide sequence ID" value="XM_003023523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5E6"/>
    <dbReference type="GeneID" id="9577041"/>
    <dbReference type="KEGG" id="tve:TRV_02316"/>
    <dbReference type="HOGENOM" id="CLU_033910_2_0_1"/>
    <dbReference type="OrthoDB" id="5324651at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40071" checksum="2FF35240C6EB0435" modified="2010-05-18" version="1">MKVQDDERQRVFRAYRPLFVGESALIRKKKAIIKRIESLKCPPDADLIMDLGQDKIVDILQSLLTDDAFTPKLIAKEPPSAILLRQQTTKGDNVKISVLSKSTEPSCDNRGLGKKGHSGDIDENVADKDLENSSSKDEVSIQDSSDDGSTNLSHAPFPIQHLVLTKIQTLLEQACFDFASKWATELISTEMWDCPEAIELSKWTLALNKVIHKIPINAFNAEDYPNIRSILHSGYEIRNIAVHRKRVSLQKLEDITQAAILFLRAIRDNNRELQLSNVHAVMSVFMWSLESRRQIIEARFREELGDIQRLRKALDLREKEADEAMRKANAKVNDLTRYMLEHSLREIFGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5H5</accession>
    <name>D4D5H5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023598.1">
        <property type="nucleotide sequence ID" value="XM_003023552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5H5"/>
    <dbReference type="GeneID" id="9577070"/>
    <dbReference type="KEGG" id="tve:TRV_02345"/>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000008">
        <property type="entry name" value="N-terminal nucleophile aminohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="44936" checksum="4399833A83312479" modified="2010-05-18" version="1">MTVTYAASSESTPQPRFRPTVIIHGGAGNIVRSRIPPELYERYRASLLKYLHSTVTLLNGEQEEEDGTKKKITPYSAIDAAVHAVSLLEDDELYNCGRGSVFTLTGTHEMEASVMVCSLLPETQGCEDVKRALIKRGAGVMMLKNVRHPVQLAREVLLRNDVEGHRGNGESMHSHLCGPYVESLAKEWGLESKPDEWFFTQKRWDEHMKGLGKGASIDHDSLPKPGEDISKYLSQGTVGCVCLDQWGNIAAATSTGGLTNKLPGRIGDTSTLGTGYWAEAWDVPSSSTRRALGLSCTGNGDSFVRVAAAHSAASLLKLGAKDSLADAITAIAGPGGELQRSAGPRWGVTGEGSGGIIGIEAEVPHDAEQRQSEEPIKGKAVFDFNRGGMLRAWTEEDADGVLRERMMAFRDEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5P9</accession>
    <name>D4D5P9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023438.1">
        <property type="nucleotide sequence ID" value="XM_003023392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5P9"/>
    <dbReference type="GeneID" id="9583458"/>
    <dbReference type="KEGG" id="tve:TRV_02422"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="40550" checksum="44C84C14FC0C99FC" modified="2010-05-18" version="1">MATGRTTFVNTLCGKQVLQGKDADDAQTAHLEEGVRIKPVTVELELDEEGTRISLTIVDTPGFGDQINNEESFSEIVGYLERQYDDILAEESRIKRNPRFRDNRVHALLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSFTPAELAESKKLIMEDIEHYRIPVYNFPYDIEEDDEDTVQENEEYRSLMPFAIVGSEDVLEIGGRKVRARQYPWGVVEVENQRHSDFLAVRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGASASHDSTMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREINEKRQELLARESQLREIEARMQREQAAQQSQDPNGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T4</accession>
    <name>D4D5T4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023355.1">
        <property type="nucleotide sequence ID" value="XM_003023309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T4"/>
    <dbReference type="GeneID" id="9583375"/>
    <dbReference type="KEGG" id="tve:TRV_02457"/>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="415"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="508"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="512"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="653" mass="73433" checksum="3F0A4F3B9DE6BF8E" modified="2010-05-18" version="1">MLYKQPQRPARTLRGRVDENMIAFNRAGKTIHHRNKSSPALSALANSNSNSNATSKEPVRRAAFGDVSNTVNSLRSAKDDSSLPSKDTIKITEKPLCLARPAQRPIHSISTKPAVNAIINAEVGIKPGSEKTQAKKIQTKRANAVFKDPILQPVVEEPTTKQQKPQQQQQQQEKASAPQASVSEASSKSAEPSKEVEKDVKGATNPPKSATTEPAPAQVTKTMPAATAVAEEPAVKEAVVKATVEPGPPVPNHNAKDANEVTKPKVTRISSDGARGSMQSTKRPSDITVSSRKYDQSEPEEYWDEEEEDNYDEDGYATARSYRSRDNTTGGATMVLFPRMSQQSRRELALARQIMETSTSVEEYDDEWRDTTMVAEYGEEIFQYLRELELKLLPNAHYMDNQAEIQWSMRSVLMDWLVQVHHRFSLLPETLFLCVNYIDRFLSCKIVSLGKLQLVGATAIFIAAKYEEINCPSVQEIVYMVDNGYTVDEILKAERFMLSMLQFELGWPGPMSFLRRISKADDYDLETRTLAKYFLELTIMDERFVGTPPSFTAAGAHCLARLMLRKGDWTPAHVFYSGYTFGQLYQLIGLILECCEAPQQHHLAIYEKYADRRFKRASIFVENEMLNGYRLPEVHEGSSLWSMLDRRASSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5T8</accession>
    <name>D4D5T8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023359.1">
        <property type="nucleotide sequence ID" value="XM_003023313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5T8"/>
    <dbReference type="GeneID" id="9583379"/>
    <dbReference type="KEGG" id="tve:TRV_02461"/>
    <dbReference type="HOGENOM" id="CLU_1611992_0_0_1"/>
    <dbReference type="OrthoDB" id="5406216at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055345" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="164" mass="17666" checksum="5E7F049CCB1F52BD" modified="2010-05-18" version="1">MWFSKGSALLAICSLLSTSVFAADRPPSVSSPTPAIRQRSEEAHDSRPLPADPIIKGRAIVDAPPDPVPTVPTQVSPITTFWLEGVQVVYTQTFPPFPDPWPSPMAGEIGLGTLKGEIGKTVTIKGRSVPTDEPEPMFARQCRTLECGKSREQKAERAGLEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5W7</accession>
    <name>D4D5W7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023388.1">
        <property type="nucleotide sequence ID" value="XM_003023342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5W7"/>
    <dbReference type="GeneID" id="9583408"/>
    <dbReference type="KEGG" id="tve:TRV_02490"/>
    <dbReference type="HOGENOM" id="CLU_021165_0_0_1"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31247" checksum="DD23B5113E57CF32" modified="2010-05-18" version="1">MFMLQFAHIFGEETLLSTTDFNVLLTFLSRDRNIILYDGKTVKFRDASDTTDRITEEDASIASLKATIARLTLQVSTLSEKIKELTGNAQKALANKNRILALSSLRLRKLAERNLQQRTDTLWQLEEVYSKVEQAASQVDIVRVMQASTGVLRQLNSQLGGVDKVEDIVEELRKEMDNVDELGGVINEAGPVIDETELDDELKELEDQEREAGEEKDAEETRKRLAELEKNQGVIKTPAARATDDDLEESIDKLSQMAIGDHPTARAKQSTKALAETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6G4</accession>
    <name>D4D6G4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023167.1">
        <property type="nucleotide sequence ID" value="XM_003023121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6G4"/>
    <dbReference type="GeneID" id="9583187"/>
    <dbReference type="KEGG" id="tve:TRV_02689"/>
    <dbReference type="HOGENOM" id="CLU_058490_3_2_1"/>
    <dbReference type="OrthoDB" id="4180362at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="283" mass="32089" checksum="22BF885AF3236D19" modified="2010-05-18" version="1">MNHGEQEDTGEVALAAHSLDTSEYRYPGVDDARTICGREYDRFLAGHKDNPFTIFTRVSESDFVELDRAGFRRLDYIASFRKLAITTPTAPHEEAGTRFSALVSLKAQEMGVWRLLSSRGSTTMETQERKKEPDASWGPRQRYSETNIKWPTVVLEVAFSEPKDKVKDDAWWWLYRSNGAVLKVITIDIKRESGNVYVTLWERGAAPSRQHPRPEARAVSTLNIFRGQHGNPARLEGTDMALPFKDMLLRDPNPGHGEGDFMFSPAELLEIAENVWADMRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6R3</accession>
    <name>D4D6R3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023100.1">
        <property type="nucleotide sequence ID" value="XM_003023054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6R3"/>
    <dbReference type="GeneID" id="9583120"/>
    <dbReference type="KEGG" id="tve:TRV_02790"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="731" mass="83207" checksum="DDA2233375FE5316" modified="2010-05-18" version="1">MSFQIPNRVPAFNSAQREIEDGYWRAATTNSQFAKQSGIQLTERIGNFITPSRELPMYKDKPYYKSRGPYSGGRKRKKALWVAICIGFLVGLWWFLGGRSGHTRIVRPIGMKGGDMWKWMQEFEKGVVSGKEKGKTIDWEERKQRVKDAFLVSWEGYEQDAWEQCSLDQWLTLHVGKDIYEPLARKGKNMAEGGMGWIIVDALDTLMLMNLTTQVQNSRKWIQNSLRYEQNQDVNTFETTIRMLGGLLSAHYISKTYPDLAPLAEDDDGASGDDLYIEKATGLAERLLGAFESPSGIPFASFNLNSSQGIRSHTDNGASSTAEAGSLQLEFKYLAKLTGETHYWEKVEKVMEIIDGNQMQDGLLPIFIMADTGKFMGENIRLGSRGDSYYEYLIKQFLQTSGEEPIYENMWNQALAGIRKHLITYTKHASLTIVGERPSGLTEPLMPKMDHLVCFLPGTIALGATGGLPLSKARKTPGWNRRKEDEIILAKELVKTCWATYLATETGLAPEIAYFDIDKPPRMMDDVFSKPKGESEDGEGQKTTGKAKEEGIYLFSKPLEPLGDKNSAWREDVIIKPSDRHNLQRPETIESLFYLYRITEDEMYREWGWEMFKSFIKHTAVIEDETPKQNQDGSSEQSTSDDNSPAAKSSYIRAFTSLSNADTIPPGRIDNMESFWLAETLKYFYLLFSDKDFIPLTETVFNTEAHIFPRFKMGKLFKTGWKRKTEWKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6X1</accession>
    <name>D4D6X1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023027.1">
        <property type="nucleotide sequence ID" value="XM_003022981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6X1"/>
    <dbReference type="GeneID" id="9583047"/>
    <dbReference type="KEGG" id="tve:TRV_02848"/>
    <dbReference type="HOGENOM" id="CLU_039316_0_0_1"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42086" checksum="0259CFD26668EA07" modified="2010-05-18" version="1">MESEGRVLRPRARKPFELPSADSTAPPTPAPEDANKEMFPGNSNGNDTGNGSLTATMDKEGLAQSSRTKSDINLTSSTLLGIYSPTAFDGGREDRDIPGTTPWGTGAQTPNLRGSGIFENGNGAKASGNGAVNRFSEEQRKRKLHKQEQDRQRQNEVRRRQRGLVRGYLLPALQQSGLLFLFGVTFGVIIMHLHDSPQMADLLPLHIPVRVEIINFGLEWWHYLVFWGVAGVALGNLLPWFDLMWEDFMGENPVKGSSEAGWNPMVRSIGAFVGVAFAIRKLPWQSSTQVCLTLALVNPFLWYLIDRSKSGFVLSTAIGLTGMMALLEMNPDIIFSPSNAADAVDETVFGIAGLTLTQGQLAVGTWIASVLFCSCVCFGNIGRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Z5</accession>
    <name>D4D6Z5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022968.1">
        <property type="nucleotide sequence ID" value="XM_003022922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Z5"/>
    <dbReference type="GeneID" id="9583016"/>
    <dbReference type="KEGG" id="tve:TRV_02873"/>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53835" checksum="1CDB8BA3A8D95ACF" modified="2010-05-18" version="1">MQCGTANATPFLQVVFESDSGHRRKSSFVSPDTPRLARRHETQTSDQAACFVHSLLGQPRAVQLDHIDEHGKAVTPSVGQQFEDGGDNTSGPSRLLTKKELSDMAWNVRALSKKLGSLKLKLNVHSIFILTKPQDQSLARLTKEVTSWLLGPEQRVPYTVYVEKRLENDSQFDAQSICKEEPTAKQRLKYWDNCLIEDHHHLVDFVITLGGDGTVLYASWLFQRVVPPVLSFSLGSLGFLTKFDFDDYKETLQRAFTEGVTVSLRLRFECTVMRSRRRSSGQPQIERDLAEELIGEESDDNVTHSPDKMFQILNEIVVDRGPNPTMSSLEIFGDDEHFTSVQADGVCVATPTGSTAYNLAAGGSLSHPENPVILLTAICAHTLNFRPIILPDTIVLRIGVPYDARTSSWASFDGRERIELHPGDYVTISASRFPFANVIPSGHRSYEWIQNISRTLNWNSRHRQQKPYDSKYLEQTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7H4</accession>
    <name>D4D7H4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sedlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022832.1">
        <property type="nucleotide sequence ID" value="XM_003022786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7H4"/>
    <dbReference type="GeneID" id="9581556"/>
    <dbReference type="KEGG" id="tve:TRV_03056"/>
    <dbReference type="HOGENOM" id="CLU_083394_0_0_1"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17373" checksum="9A339C28843F0503" modified="2010-05-18" version="1">MSLFEPHVDDQLEFSFILNSSLDIFDMRQQHTSVDQDLGLLHALDERLSVYGWLTNTGVKFAIVVDLEGRTSAHSSAHERPLPVVGLRDSDLKPAFRALQTAYVKLLQNPFYNPDDNVLGKESQTQSKPKGIASRQFVEEVNRIGRTWAPGIAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7I6</accession>
    <name>D4D7I6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome oxidase complex assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022844.1">
        <property type="nucleotide sequence ID" value="XM_003022798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7I6"/>
    <dbReference type="GeneID" id="9581568"/>
    <dbReference type="KEGG" id="tve:TRV_03068"/>
    <dbReference type="HOGENOM" id="CLU_092488_1_1_1"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19742" checksum="143C3D34FA5EDBED" modified="2010-05-18" version="1">MLKPNVSLRSSTPARRTLVAPPQPNSGPLLSRRADRELPSLGSHRRWLRTIPIFLAIIGVSSLAIFNYQKSSSSIVSSTLYALRHSPKARELLGDEIYFAQQIPWISGEMNQLHGRIDISFWVKGTRGKGKMRFKSTRESRLGYFNTEIWSLEMEDGTAVPLLNQTEEDPFKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7U3</accession>
    <name>D4D7U3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022716.1">
        <property type="nucleotide sequence ID" value="XM_003022670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7U3"/>
    <dbReference type="GeneID" id="9581405"/>
    <dbReference type="KEGG" id="tve:TRV_03177"/>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1 5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="9">
        <location>
            <begin position="206"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="8">
        <location>
            <begin position="564"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="783" mass="88803" checksum="9711F3FE17B674BD" modified="2010-05-18" version="1">MAIQKKHGKGRLDKWYRLAKEKGYRARAAFKLIQLNKKYGFLEKIGVDLSPIKPIPKVITFQSDITTDKCRATIRQHFKTWKADTVLHDGAPNVGTAWVQDAFSQAELVLQSLKLATEFLVPGGTFVTKVFRSKDYNPLLWVFKQLFTTVEATKPPSSRNVSAEIFVVCLGFKAPKHIDPKFLDPKHVFAELQDPNPNNEAKVFNPEKKKRKRDGYEENDWTQHKELPATEFINTTDPISILGSYNKLTFTQSPGGDLALATLQRLPETTNEIRMCCEDLKVLGKKDFRQLLRWRIKVREKFGLAVKKGPKNEEETEEVAEVEPMDEELALQEDLRRMHERETSKNKRERRKENERKRKDIVRLQMNMTTPKEIGMEQAGPLGEGAMFRLQTAEKLPAARSVSASSMAAAVESSSEEEEDSSEEDSDEDGDRLERQLDELYSQYQEARDSRDAKLRAKKSRKDYETEEWEGFSDERGEESDNQSPQTFPAAPVGDHVNGLSNKAAMFFDQDIFQDLGAVEDGEASDDPSAAKTNGVTKEQSTVTNKEATKNKRKAASPSPSISSDSSYQEVELEKSETFEDDDDPNLNDDPRKKNGQLDVDIITAEAMALAHQMARGEKTTEDFVDDGFHRYSFRDVDGLPQWFLDDENQHSKIQRPITAAAAAAIREKMRAINARPIKKVREAKSRKKFKQAQKLEKLRKKSSLLAEDEGISERDKAQSIAKMISKATKKKPKQSVKLVVARGGNKGISGRPRGVKGRYKIVDARMKKDIRAEKRLAKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7W3</accession>
    <name>D4D7W3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022676.1">
        <property type="nucleotide sequence ID" value="XM_003022630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7W3"/>
    <dbReference type="GeneID" id="9581335"/>
    <dbReference type="KEGG" id="tve:TRV_03197"/>
    <dbReference type="HOGENOM" id="CLU_010627_1_0_1"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="790" mass="88502" checksum="8EBAE20747DBCB43" modified="2010-05-18" version="1">MTRPQMIRADTIDLQNRQSPSTQDHARKLGGASAVDGRNGAHQDQSLRKVEQEAQDEMSKGPLGSDGNSQVYSHRDGLEVYREHDEADGSKPNGVANGDMSHESRNGSSTEEEMEGDEDDQDLDDDMMDKISSSPSIDDENIDFEFVYALHTFIATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDGSIGYLPAEHIETPTERLARLNKHRNIDLSATMLGDNAEKSKNPLRIAMRRRHGKTVTFNEPLCFEAEEAPIDYSTGSEEEEEHFLEDDEEDEEEDEEEEEHEVHEKSAHTKQQQQQDASRKDEDMGIEPLRPKQQQKETAALQEHRSENKDSLEEHNDDLDKDFQPGRSRNGVVRNTDSFFKDDTLETKKISLTPNLLRDDSLTAQQPDKDSRVRGSFESYDKVSPSDKNKDDKKRKDKKPGMLSGLFKRRDRKTKATDDDDDQEKISEESIRSSTPTGTMGDHGRDGSKPAVALQRTPSKLQKTPPGEQQGSGARHEGGRSTSRQEVAAPQSPPATKQTFQSHGQQQQQQPHQPQQQLQQHQQHHQQRPQPRSSSAQGTRVRSPEVLRPLTNKQDRSLQERPEPNLSLVKEPRDSSESTPDASTNLPANQAQHQYSSSQTSTYSTHSSKKPASVSHAADPVQQDPELNNHYDDNFEDQHSLSHDKDQYSSKQTGSPSPTASPAFSQDPTLEDDRSQEQSVSPSTSIIPAWNDSGLRAYMDDGSDIRDLLTIVHDKSNVPAAGPDHPLIGSLFREESKALNDMSSRLDEMLNSWLSKSSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D4D927</accession>
    <name>D4D927_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022293.1">
        <property type="nucleotide sequence ID" value="XM_003022247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D927"/>
    <dbReference type="GeneID" id="9576896"/>
    <dbReference type="KEGG" id="tve:TRV_03617"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="559" mass="61603" checksum="A6C3BF5401A64DDD" modified="2010-05-18" version="1">MKLFYAKSESRKLISEKKNRKTKKKAPARLDICVVGDTQNEGRQIGRKAQMSNIAAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVAHPAAKSMIELSRTQDEEVGDGTTTVIVLAGEILAHALPQLERNIHPVLIISAFKRALSDALAIIEEISLPVEVDDDKAMYSLIQSSIGTKFVSRWSELMCGLALKAVRTVSLDNGSGRKEVDIKRYARVEKIPGGQIEDSEVIDGVIINKDITHPKMRRRIENPRIILLDCPLEYKKGESQTNIEVSKEDDWNKILQIEEEQVKRMCDAIIALKPDLVITEKGVSVKQNITALRRVRKMDNNRIARATGATIVNRVDDLQESDVGTQCGLFEIEKIGDEYFSFLRKCKNPKACSIILRGPSKDILNEVERNLQDAMSVARNVIYHPRLSPGGGATEMAVSVKLANLAKSVEGVQQWPYKAVADAMEVIPRTLVQNSGANPIQVLTALRAKHVEGRSTWGIDGDTGKLVDMKEYGVWEPEAVKLQSVKTAIESACLLLRVDDICSAKSLNQAANMGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y4</accession>
    <name>D4D9Y4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y4"/>
    <dbReference type="KEGG" id="tve:TRV_03927"/>
    <dbReference type="HOGENOM" id="CLU_3426938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="21" mass="2718" checksum="2503D903DA13E777" modified="2010-05-18" version="1">MQQEEEEEEKKKKKKMMMMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y5</accession>
    <name>D4D9Y5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000201">
        <property type="protein sequence ID" value="EFE41362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021980.1">
        <property type="nucleotide sequence ID" value="XM_003021934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y5"/>
    <dbReference type="GeneID" id="9578853"/>
    <dbReference type="KEGG" id="tve:TRV_03928"/>
    <dbReference type="HOGENOM" id="CLU_013994_1_0_1"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="400"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="934" mass="104954" checksum="11700430A006B412" modified="2010-05-18" version="1">MTTGSIFRYEAELHAHNSRSAVYPLLIRLQPSPTETKSYWQRPSSRKASRNLVDENEPFSISRESFDSYRRSFDISARSPVSQHSDIAASRTSLDSRLSRTTCPRTSTNGNSLEPPTDSNGVDDVEDPFEDVSLADDSKPKKRGLFSRFGDSPASQQTPGKHSFHFPGRRRDQRGHISFRPATYLPFPAAELRSPFTALQAFWLLPPFLFASSFSSFLLFFFLPLLHFFGKVAKMEMYISQEEDIIEIHLKELIFLEVVSAAGIYTMAGVKRRTDATEASLSKRTKSKSSAKPVEVKGKSKSKAAKVVELDSDEDMLDDDDDDDDDDEEEDDYEDGDEVDEKMEEEELSNESEKDAAKGNGNANGNAENKTSTSRESHAKQKALAQERKAARPNADAIARTKKIWERLRRKSHVPREERKKLVAELYGIITGRVKDFVFKHDSVRVIQTALKYANLEQRKNIAVELKGDYRSLAESKYAKFLLGKLLVHGDAEIRDLIIPEFFGHVKRLIRHPEASWILDDIYRTVATPVQKHKLLREWYGMEFTLMKDEISDETPSLPEILEKSPEKRAPILQHLHGMINQLIQKKTTGFTMLHDAMLQYFLSTKPGSEEATEFIELLKGDEEGDLAKNLAFTKSGARLMCLALAYSNAKDRKLLLRMYRDTVKLMSGDVHGHTVLLVAYEVVDDTKLTQKLLLSELLTQDDLVPRANDQLARIPILYSFAGKKNGWLITDTDRQILDEVCEIRSQTSKKDPEIRQRELVSAASPALLECITNNAAALAETSFGARFITEVLFDSTGDKTAALEAVAGLAEAEAAGDVLKSPNAGRMLKALVQGGRFNNATKKVEPVQPPLNFASLLYKHIKDNVQSWATEWNPFVVVALLESEEFDKRDELAATLKKSKKRLTELASKPKGDGEEKRDPASSAAKLLLDKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA43</accession>
    <name>D4DA43_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021898.1">
        <property type="nucleotide sequence ID" value="XM_003021852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578781"/>
    <dbReference type="KEGG" id="tve:TRV_03987"/>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="497"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1505"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1734"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="177"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="428"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="580"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="709"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="927"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1505"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1734"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1811"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1910"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1933"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1950"/>
            <end position="1966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2012" mass="225357" checksum="BFC6444786A331C7" modified="2010-05-18" version="1">MATAAVDIPFLASHYAIPETALTTLSESPTVELVNQLLESISTKARETEELKSDKLRLEVELENAVRGGEAKVKVLKSSVEKGLEEISNLRNKLQESGKSYKSKDIERVNQNTRSQLESEIGTLKSTSSTSEAEVGSFKSRIASLEASNRDTLGLLESKSTAYDKLAEELSTQHRKTVDLRREVTALEQKIQAASSTAASTRFREQSLQQEVDLLKKNNEWFETELKTKSAEYLKFRKEKGTRISELQRLNEEANSKVESLERSENALKRRLDDIEQKYDESLTNIQQLKEEAIQAAESFRIELDSSTRLAQLQQAAAETAKQRVQEFQIALDKARDDATDQISRLRGEIETEHSDKEAAERRIAELELAIKQMETEGSAARLQPMSPGFNNGVSTPLRPGTPVGSFSPRSSRGVKGGLTLTQMYTEYDKMRTLLSAEQKNNEELKAAMDEMVQDLESRQPEIDELRSDHSRLEAAVVEMSNILETAGKEREAATREARKWQGQVGGLEREGQILRQQLRDLSSQVKVLVMEVHLLSAGEKEYDRADLEKIAREGIEESAEDMTETGQFISRNLTTFKNLNELQEQNVTLRRMLRQLGDQMEGEEARQKDISHQKDQEELKELRVRVQTYRDEMANLVSQTKSYIKERDTFRSMLIRRRETGESSEPFSQSLPLGAAPPALDASTMSAAPGPDYADLLRKLQAHFDSFREETATDHSSLKQQVNELTRRNSELQSEVSRASSQLASAIQRAELLQSNFNLLKGENVELQKRHTALMENANKQDLRTQQVAEDLVEARGLADSLTRESANLKAEKELWKSIEKRLIEDNEALRNERSRLDSLNANLQSMLNEREHSETESRRRLQATVESLESELQITKRKLNEETEEAKKATLRKEYDHEQSQKRIDDLVTSLSSSREELIATKTSRDHLQSRVDELSVELKSVEERLAVLQHKPNTGATVPTAGDESTEAVPDNQLSREQELAIEVSELKRDLELTKGELEHAKEQAEDFKAISQSTEERLEALSDTNEQYREETDRLLEEKNAKIADLEKRVEEITSELAATNNEISKLRDQEGEAQRRMDDQKEMLEAEIKRLKENEERYTAAAQYHQQDLKTQAEIAQNAQQNYENELVKHAEAARNLQTVRAEANQLKLEVVDLRTQAESAKNNLTHQEENWNELKERYESEIGELNRRREEVLKQNSLLHGQLETITRQISALQRDRASMPENPEGETDASGTDLEGLQEVIKFLRREKEIVDVQYHLSTQEGKRLRQQLDYTQSQLEETRLKLEQQRRAEADSEHNTLNHNKLMETLNELNLFRESSVTLRNQIKQYEEAIASKSAQIEEIQQQAEPLQTRIRELENNLETKDGEVKLLQEDRDRWQQRTQNILQKYDRVDPVEMEALKEKLATLEKEQAEASTEKSALQAQIDAFPEQLKQAEEKVHDLRSKLTEQFKARSKELTGRINAKQGELNIAIQEKEAIQLELNSTREELNALKASVSENQQAAAAQSAPEPQPAPVQAAVSSEHPSAESAQKIAELEEKVAKLEAALAEKEAETDAKIRERIEKMKETLNNKLAEYKTAHKEQIDKLTAAHQQELAARPSGELPPELTDSQARELVAKNETIRGIVRNNIKNALARERESMSKEADPAALKEMEKKFNEEKEAYMKERDQKVNSAVELAEKRLLAKVSMTEGRARNAQAKLEVVQKAATETPQKPVVEVWEVAKVAKPAPVSQAATPKPAGQAPAPAQTATLPSQATQQAAAQVPAAPTTPAKPTMPTDSQQTPTPAERPEQAPQAPQAPQPSSLPQPTAQGQPQQGQEQPAQNVQPQQPQQPQHQQQPQQTQQTQQGQPVSGLPSRPPQSTHHPAGGTGPGVLRALQSGLPVARGGRGRGGPVGQVTQPHNVAGQQQQQPQQGQQGQQLGASRGHGIPRGGGRGRGGPGRGGAQNVQTGNLPAGAGQSSPRGGRGGLNAQARQFIPQGNKRTREDGAEAPETGSGKRIRGGGAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAQ4</accession>
    <name>D4DAQ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021691.1">
        <property type="nucleotide sequence ID" value="XM_003021645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAQ4"/>
    <dbReference type="GeneID" id="9576774"/>
    <dbReference type="KEGG" id="tve:TRV_04202"/>
    <dbReference type="HOGENOM" id="CLU_1653417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="160" mass="17636" checksum="6A39B735D2A44DD5" modified="2010-05-18" version="1">MEMGWGYFSRSAKSHGGIMYLPGCPELQVKLLDSSSMTLEAQGGALLCWMIGFSQGARRVMAAAGTVVDAPRGKTASLDEERRRLMLAMRHGEGLRRTGKQLCMVNVDGSLAWTAFCVPRCKDGLPRTMHGWQMRHTHAHAHWCTCSVLGMRPLLCGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV4</accession>
    <name>D4DAV4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021622.1">
        <property type="nucleotide sequence ID" value="XM_003021576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV4"/>
    <dbReference type="GeneID" id="9578583"/>
    <dbReference type="KEGG" id="tve:TRV_04252"/>
    <dbReference type="HOGENOM" id="CLU_1120083_0_0_1"/>
    <dbReference type="OrthoDB" id="4148828at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="255" mass="28094" checksum="B5ADF2DF58B631A7" modified="2010-05-18" version="1">MEGGWNQISPPADAKETGFPSTNGISEQSARSSGGDLVRTRSKPWRYSPRGFGSRKNNELLDSRKGGKEDTSMISTTKDKADFVYKPASGEFLKTMAELGKPKNGRYSSEMTRSVVNNRHTSLQSNSSLEPTLPGEIPRHPFHQDFSTRSQSPANQTLSNKSSSPTEHYFDQRTPATNHSTSARNSSARDEDCSSYVSPMDVEKSPRSIISDTAAVPTYLPSNPAPSEQSRRKRKAKQKRVVTSEMVPSTNDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB41</accession>
    <name>D4DB41_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021493.1">
        <property type="nucleotide sequence ID" value="XM_003021447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB41"/>
    <dbReference type="GeneID" id="9578474"/>
    <dbReference type="KEGG" id="tve:TRV_04340"/>
    <dbReference type="HOGENOM" id="CLU_1983184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="13775" checksum="1492362DBF215805" modified="2010-05-18" version="1">MKDGGKADGKKSIKAEDRRGGGVEVEVGGGRGGGGQVDCDGRPVVRTQRGWQGIRSGEKEREKRRGGAKEKRTRKKKSAKRRLLPVLSPYHTSIFPTPVPVFFFIVIPVKCQGKGFEVEVEVGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB58</accession>
    <name>D4DB58_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021510.1">
        <property type="nucleotide sequence ID" value="XM_003021464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB58"/>
    <dbReference type="GeneID" id="9578458"/>
    <dbReference type="KEGG" id="tve:TRV_04357"/>
    <dbReference type="HOGENOM" id="CLU_034574_0_1_1"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35419" checksum="E6ED4C5652F032AF" modified="2010-05-18" version="1">MPPPVLSKLWPGPPESSEKAPRQSFLARRPAIPHRILHSLIYFVAFVMLLLVQIGNLSDRLVLRDIYFLKIDLSNIVPLTVPNAVLINSIARTIGLHDFYQVGLWGFCEGYGDGSGITRCSKPKPTYAFNPVEIITSELLAGATKTLLIIPVVLPSGITRALNIARVASNWMFGFFITATILTFLCMILTPFSIPSSAAILSAPNYSSYYRAKKRAAPSKIAIPIAILAWGAWFTASAGAAVATVMFVIFQVVFENNAADLNVHAELGIAMMALMWIPVALVTIGFLLQLRKLTGSCRNCCYYCCCCCLFPSARKAHENSKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBA6</accession>
    <name>D4DBA6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021558.1">
        <property type="nucleotide sequence ID" value="XM_003021512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBA6"/>
    <dbReference type="GeneID" id="9578519"/>
    <dbReference type="KEGG" id="tve:TRV_04405"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_1"/>
    <dbReference type="OrthoDB" id="4207436at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="134" mass="14882" checksum="338C6F4FA392AF37" modified="2010-05-18" version="1">MNGHAEVVKLLLKARDMDIDSRDSEYGQIPLAWAAEKGHHQTVRLLETGKVEVDFKETVSGQTPLSKAAKNGHDESFAEMGRVEVTKLLLETGKVDVNSENSQFSETLLLWAAEYRHSSQAASWDWDGGYGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBE4</accession>
    <name>D4DBE4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000223">
        <property type="protein sequence ID" value="EFE40830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021448.1">
        <property type="nucleotide sequence ID" value="XM_003021402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBE4"/>
    <dbReference type="GeneID" id="9578408"/>
    <dbReference type="KEGG" id="tve:TRV_04444"/>
    <dbReference type="HOGENOM" id="CLU_2090653_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="117" mass="13272" checksum="767B7781BD334835" modified="2010-05-18" version="1" fragment="single">DATDILSRVSLIHMDLRDIPAGFRACNKQGKPISSRRPDMFMPKGKHAQGSWFISRYFHSSAGKYQSTALYVRKENRRLALILSRRLAAGNPRDCSQPGKNRTAKAKHIHIVKRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH4</accession>
    <name>D4DBH4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021400.1">
        <property type="nucleotide sequence ID" value="XM_003021354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH4"/>
    <dbReference type="GeneID" id="9578279"/>
    <dbReference type="KEGG" id="tve:TRV_04474"/>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="504" mass="55317" checksum="4EB6917692F50CD5" modified="2010-05-18" version="1">MDSKPYPQPAAGFESHTPFWRTSPHKLDTHRSTPNLPSECDILIIGGGYSGASVAYHLFQGNEAPPNTVLLEARQLCSGATGRNVTNSNNEKAGHLRPEMYGHASKFISRHGVEAAAEIVKYEISHLQILADVIEREKIDRDFTLTRSLDVYFDQDVMDKVLRGVEPLLSDSYQHGKYAFMKDAVIRFPTAEQPISEDDLMKTKVKGAKGYVSFQAGHIWPYKFISGLLEIAVSKGLNLQTNTPVLEISPSRDTEGLWKITTDNNRGTIRAKKIILASNAYTSALAPEYVEAIIPCKGLCCHIVVPPAEDGKKRPPPLENTYVTRHGSGAGGYLIPRPDGSMIVGGASHTFTPLLEQWHNNPDDGALIDIAKEYFDGYMQRTFIGWEDSGAYSKEIWTGGKPFPPVFPFNGLDSQLVDTNKTDCSVMGYSADSLPHIGKVPSKDGQLILAGFNGHGMPVCFLAGKAVAAMALDDSVAFEDTGLPRVYKTTIDRLQPKYNDTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC10</accession>
    <name>D4DC10_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021230.1">
        <property type="nucleotide sequence ID" value="XM_003021184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578075"/>
    <dbReference type="KEGG" id="tve:TRV_04662"/>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="574"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1876"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="2962"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1327"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1494"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1495"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1519"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1679"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3096" mass="349311" checksum="458DB9306F7BC4BE" modified="2010-05-18" version="1">MYVKNFDAGQLNVGIWSGDVKLRDLELRREALDQLHLPLNVIEGHLGELTLSIPWSNLRGKPVKVHIQDVFLLAAPKEDSTYDPEEERKREHAVKMEKLESAELIKEQNTEGMSQEEQQKNQSFTQSLITAIVNNLQVAIKNVHFRYEDAIAAPGHPFAAGVTIKELSAVSTDSNWKPTFIQSTSTSNYKLAVLNSLAVYWNTDAELFAPDHGASAESGEAGDTDAPIFSHADLLEKFRDAVATGENNQYILKPVSGKAGLELDTSQNVDHPRAKAKLIFDELGFVLDDHQYRDVLMLVDLFHYFIQHREYRSLMPACRPKEDPRAWFRFAGQAILSKIHERNRKWTWGYIKERRDNRIRYIELFKMRKREDPMSPAETEEMKALEEKLSYEDLRFWRSLARNQLRKERIECPKKVVRQQTWSEWIWGTSPKEEDQPTSMTDEQRQELYQAIDWDEKKAIADAVDLPRDSVKFQVDSSLRAGSFTLKRDPHGKADEILKLVFENFQAKALQRPDSFLVQVDLGGLRLFDHTTDNTAFPQIVRVKDSYSMPSENVEEITEMDIPESPDVETIDLEIVKFFRPPERHMESIGALLETAGATVAEIRQQTRAGLEFALEEHKTINAQLDIQAPLIIIPESITTGDSMCLIFDAGRVSVISKLVDKETLKMVQSKQGTEIGDDDLSRLESLMYDKFLLKLDSTQVLIGKGIEATKAELDPKTESKNLHIMDRINMDFVLELCIAPKSTLTRTRISGHLPEFHASMSDTKYKNLMRLIDIAIPRFDTDESSTNSAEKVAQPETTSVESRARSQSIQFPRQKDVPVLQSENDIAGPDDKKSAESKTPKNIHRRMFEFKFTVDTLRGSLYRSDPSDERKDRLLVELVAEHFQLDYNLREYDMAADIVLKSLSIEDYIEEHSSAPEFKKIVTSRGFDANEEKDLFTLKFIRVNPSSPEFVSVYDGVEMNLDLVVSTINLIVTRKTLLTLLDFILITFTNQNPQDQVQSSHEQAASNDLKEAPKPANTGKIRISSKLERISLILNDDGIRLATLSLNTADVGIFLANETMQIKSRMGSLTLFDDINENGKSSTVRRLMSIEGDDFADFRYQTFNPKLKDYPGYDSEVALRSGSIKINFIDEPYRRVINFLVKFGKMQSIFNAARQAAANQATQIQESSSLMHFDIMVKTPILVFPRITDRDGPRDFITAHLGEIYASNEFSQADHGEAKYLVNTITAGIRHIRLTSTFYYSEDVCEELEMIEKVDMDFNIKYVQEPIDNSIPVMRVDGSMSPTNLRISQMQLKFLLELSQTIPAAFSPDQELQEGQAQQALPELSAGLSTAASSDKSNESKSLTDGPGKNAAEPKKSIQLELGFRVETIGLELLLVNEEAPVQSLDDVSLSKFFLSNTNVKLRMLNNGSLESELLIHSFNVRDSRSKETNRFRKIMSLVNTEVQQQFMASLSMSGGTDRQLVVMVTIDSPRIIFAVDYLFSLKSFAAAAFPAEPDTDASESSDEESSGPAVSRDNLPSKPTTIPSSAMTAENKSSLTMSFRFNMVDSQVILVANPTIANTEAIVLGAKQIVYSQQNASTLQITKVGMFLCRMDKFETSRLRILDDFSLELSMDTQSKSKSFSTTRIDMHVEPLILRLSPRDILLALQIMNRVSEMTSPTQPQNAASESKAIAAKPTQADLQSPSTPVQSRLTAADRIQQSSIVKKEEMSIQMDGIRVILIGDVHILPLLDWSVQSFRVDVRDWSANMSADTTFDTFINVYNFSKSTWEPLIEPWQLGFHMSKELSPDIFSIDAYSHKNMELTVTSATIALASKTMQFLSADEDVLSKPRGTDTPYRIRNYTGFELRVWADTGNGEEGHACTLEDGEEYPWRFEDPTTMRENLTPEGNAGTVGIKLEGSGFDSISRIPLIREGETLYNLKPKKDKVLHKLLVEVSLGTDYVKYITFRSPLVVENKTQIPVEVGVYSPEEGHLLKIEKILPGDSRPAPVGAAYLHSLVVRPDQGFGYNWSNERLFWKDLLRRPTRTLKCQSENGQQSPPFYFQMNATFDKNDPLLSVYPYMRVRVSAPIEIQNLLPYDFKYRIYDKNLKKDWTNFLRKGGVSPVHVVELSHVLLLSIDMQDTAFRQCEFAIVNGNVQEDFRRESTLTVQDDQGQELKLGLHYFTVPDSGGAFKVSVFSPYLVLNKTGLDLNIQSKGVFHGGRSAAGRAIKTDAMNGVRSAIPYMYSYPTDDRKNRSVLRVNGSSWSKPQSFEAIGSSFEVTLPGSNGRTEYHAGVTVEEGTGKYKVTKIVTVSPRFILENRLDEELVAREPGSSNVISLKPRELVPLHFLRQAAEKQLCFCFPGVNNQWSSLFNIADLGITYVKLAKANQRQRLLKVEVLMEGATIFLRISMEAVHWPYSMKNESDAEFIFFQANPNVSEDEDDRSTTWRPIRYRLPPRSIMPYAWDYPAAKNKSLVLLCRGKERYIKLAEMGNLIPMKLPPTQDLPQKIIDIRIEAEGPTQTLVLSNFRPSRSVYRQQKPASSQTSVSTGFEVKEINSDITFKAQLRLNGIGISLVNQNLRELVYITFREIDLKLSESKIYQTVNTTIKWIQVDNQLYGGIFPILLYPSVVPKTGREMEAHPIFTATVTRVKDDSYGVLYVKYASLLVQQMTLELDEDFIFALLDFVKVPGASWSEEREDPICEAELGIPEPKHEAQGQDVYFEVLHLHPMQLDLSFVRTERVNVEDTTESSNPLMFFVNVMTMSIGNVNDAPVRLNALLLENARVSIPMLVSNITNHYTQEFLRQVHVVIGSADFLGNPVGLFNTVSSGVADIFYEPYQGFVMSDRPQELGLGIAKGATSFVKKSVFGITDSLTKFTGSVSKGLAAATLDKEFQDQRRMSRARNRPKHALYGVTAGGSAFATSMASGIGGLARHPLEGAEKEGFQGFVKGVGKGFLGLATKPALGAFDLASIFDAGGLDRVRLTRFIGRTGIVKPYSQREALGQFWLKTTDDGKYFNEEYIAHLEFPGKDMLVLLTYNRIMLVRSKRLTTEWDIKLTDIQKISKERTGMTITLKGGTNGPFIPVQDESGRNWFYKQIAIGMFTYHRFSRQVEHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCB6</accession>
    <name>D4DCB6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_04769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000242">
        <property type="protein sequence ID" value="EFE40502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021120.1">
        <property type="nucleotide sequence ID" value="XM_003021074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCB6"/>
    <dbReference type="GeneID" id="9577967"/>
    <dbReference type="KEGG" id="tve:TRV_04769"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="69"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="487" mass="52814" checksum="FE630BC0F297FB42" modified="2010-05-18" version="1" fragment="single">MATEKVEGVSMEESSPGVQKFASSGSDMALEEKGEELGFWTRLGCTPESFKRRRLTGGNQLNQTLKSRHLHMIAIGGSIGAGLFVGSGSALAKGGPASLVLDFAIIGVMMFNVVHALGELAILFPVSGGFYTYSARFISPAWGFAMGWNYVFQWLVVLPLELTVTSLTITYWKVDVSVAVWITVFLIAIVIINIFGVLGYGEEEFWASAIKLTAIVIFMITAIVLACGGGPKDGLYGQYWGARLWYDPGAFRNGFKGFCSVFVTAAFAFFGTELVGLAAAESRTPLQSLPSAIKQVFWRIILFYILGLFFVGLLVRSDDKRLLGANTYSDSNASPFVIAAKDAGLYGFDSFINVIILISVLSIGNSAVYAGSRTLTAISEHGYAPRIFSYVDKAGRPLFSTILVIVFGGLAYVNVSGKGPVIFDWLQALSGLTALFTWGSICYSHIRFRAAWALRGRSLDEIPFKACSGVYGSWIGLFIIFIVFIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE7</accession>
    <name>D4DCE7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021087.1">
        <property type="nucleotide sequence ID" value="XM_003021041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE7"/>
    <dbReference type="GeneID" id="9576739"/>
    <dbReference type="KEGG" id="tve:TRV_04800"/>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="195"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="885" mass="98190" checksum="19B58BF4C90CB8A3" modified="2010-05-18" version="1">MPDQNYQSDMRRSIFNKGPDFTLETFSSRDFIVKDFIESLSDAAIQRRSGGIGNQPFDPKPLIRAFEHAQRRLTELSGDLEQRENELSAAVRKAEAQHTQNASNLGWKLNQAIESFQKLNTSLNGPRRPSTRDGPGGNGNVAVETGKKLEELDRQRRKALDAHFLIGCWDEVSNRGELTMLENLRRSGSAEGKVRSARIARQLLRISQRLDPLSWSESNGGTDTIPPSPDDHAGTNGNTPKRRNTREIIEKFSETLEKDLLKQFDHFYRKANFEGMKDCASVLQDFNGGASVIALFVNQHQFFIDRSQLISEEVSGDSEAWEQLADPDAPSPGVEPSLQSLVDEVQVVVQEESAIIKRAFPYYEQVLCKFLQRVFQQSIQQRLELVLDKASSVSSLAYLRTLQSARSYISALVDDLKAHGLTEHPDTISSQTAIFLDQQLEELFIPYLVGTSYIDREKNNLEELYTSLMFKFATFHSRRKKTPTTFMSSLAKSGSELLASARDAYINSLDSSDFTPTQRKMLLRVAGLKENGEMQKQNEIELMEEDGQLSVAFAKRMLRWLAEGVGRSLELSVSSETPKDVSTLLNMLLSRMGEGYIEMALDASLESAHAQESGKAEPDFNYLTTLRTAISVTYLMMTCINAVLVPLAASNITIKRDMEKKTNLIMHRIEEKINSIEQKTVDVTLAWVARVLSGQKKNDFRPKEGVADETGWLEMLQTPTCASISGFLTRLHNITLTSLPSSGSNVRVFLTEIALGTRALLLEHFKKFPVNAPGGLMVTKDMTRYTELLRSWNIDESVKSVGGILDVLLEVGSLFVIGPQALKERVRAGTAGGGSGTSTGGGGGGTTSGSQSKSNAGLTVQEVRAYVLRREDSGSAAMQDVFNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCI0</accession>
    <name>D4DCI0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanyl nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000247">
        <property type="protein sequence ID" value="EFE40441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021059.1">
        <property type="nucleotide sequence ID" value="XM_003021013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9576702"/>
    <dbReference type="KEGG" id="tve:TRV_04835"/>
    <dbReference type="HOGENOM" id="CLU_001112_0_0_1"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000053">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2115"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2146"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2171"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1315"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1974"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2055"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1867"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1893"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1912"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1931"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1974"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2063"/>
            <end position="2072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2324" mass="257788" checksum="AF4B96597EC1F201" modified="2010-05-18" version="1">MSAMSAIAAARECDQDEPADVLLPQTTYQPADAFADPHDYYLQHHHHQSHQSHHQSHHQSHHQRDSRPGSSSIGRGRGSSLAERGLPDFSLSPSKTRTATATPATTTPVSTTTSAYKSRQSSLQDLVNRFNQTPDEVVPKPSAVSAHAHARPPPARRPLFGEIIPKPVTAAPVITTATTTPALLQTGSGSRRARSGSDSCMHTPKQLHFLDSAFDHLPQHHYQNSQHHQQHHQHQTLQTQQQTHLQTHQHIQVDSPTAWYLPALSHRRSQSDLGSPVSPQLNMNPHPISTSFSSRQYQHQQLSRIPLPSRRASQASDSGNSSPSTRTNSALDRYPPVSGPLPPKGISLLPKPTSPPTASTATFSPRYRNRSCSTNTTATTATTSSTASSRRQQQQQQQQQQQQQPQHQHQHPHHQHNQHPIPRDQKSPTLQAFISAPLPKKSPPLRSSRPRQPVSSATTSASRARLVDRISGLQSKDGRAASASASAASHPTTAGSRSASASKKPPELGNVDFAARRQRIQQAFNRTVEENAKKEERAAVRREREIARKMARQEKLQPQPQLDQQQQQQPGQQNQQLEQPQPEASTVPEPQPIPEPEPEPQILDQVEKPTEPEPQPETESGTGTGTETETEQTAADPTLVPEELSEPTTTTTTTTTAEPAKIIIEEEETEQTTTAGDRPVNNDCVEPQFTPEEHNNDDSFVTPQEGRSPVLLPVTYQPDQQPEAQQPLDMALHSPYRPKTPESDNTDAVPQSAVTVGTEITTFDPEPQDGLLTHRTMLNHIMQMRESSPSISGTSDGHDDEHDTEHDDTEHDDSTADDGESIRIMLRRSRYLESIARQHEVGNPRHRWSMSSWDSSFQGHPPQGEAEAVSDLGQEDEALTKNQEQEESCESSHSLHENATTPQPIFPPSPPCEADEVHNPGISPIKQQQQQQQQLHESHDVDDDSSESPVLGNDDHAVIASLERRFSMNMANHYTTIAKQACWDSKRATQLYLQELAKAGYERPRVPILTPGSSESEGKRLSAHDSVSRGTDDGDGEDGVLVADSSTIPTAEFLPARASLHLRDDWETSPSIADWMHLAAGEDEMQPPQSQSQSQSQQQPHLPQPEHEYQQHQRQATDATEIPHPSTSTSTSSPESPSASDQEGAETPRIAGPPQFASIDGTVEGLGLEIRVQSPQDGDSPTIPSPFHMHLPVPSQPHHPPPPPPVTSSTSTAAVEDQHHQHQHAVSVEVSPSVYANSPPTSPMPALPTFHDAPPSSRSEDSSLHITPPHTISSSTSHTQDRPSSLAPETTSAFHDILDPASRISPTPEERRLKKRRNVIKELVDTEYTFGQDMTVVVDIYKGTSSSCLGLSPEDIKTLFGNSEQVVQFSMDWQDALKQAARSVYILPKSQRWSSKRSSKCTQNSSATSNSPEPQQIADEENDRKTAIGEAFMANIERMEAVYSDYLRNHDAANRTLEVLLKNKNVNIWLKECREWAADLTSAWNLDSLLVKPVQRILKYPLLLTELLSATPSDHPDYTAISNALTATTAISVRINEMKKRADLVGQVVGSGRKRKESDVRAGLSKAFGRRTEKLKQHVGITEMFADKEYDILSQRFGDNFFQLQLVMRDVEGYLSEIQSSMNKFNDFIVAVERYINLAPSNYPELESKWCRFRLAVKDVMTVALVDHIAQVRKSVITPMVTLLKLHDGPQRVMQKRNKRLMDYVKYKAIKDRGDKPDKKITEQGEQFVALNMALKDELPKLLSLTGKLMEACLNAFVQIQATWLNLVQSRLGYSIERLPQDVNQIITDWSGDFSFSEAQVLSLGVCNGSILADTALVNNYSSPPPSHGADASSSRRPSTVNSATGRTFSGESGNSPKGSHEFLSRSPENMIQTPPSTGFMQHGNGSYVFPASSGSRTRANSTYSVRAQDVTSSHIPSIPSIINSSTRSSVTAQSGSNASFRTSDASPKLPLLSLDTPRLEFFPDHLMSSSRYNINVNGNSNSNNRNSNHHVAPDPADHPSSPSATRYSGFFSSAMPMAENPEPSSRFHSHASIPMNRSAKRVICGLPETKTIPRTRSAGYGRSTSPNWQADNKSKNRKEKKKAISMIYIHRYVFLFIFDPDISLSIPETNSFPFISFSLVLSCLFVLSIISFVIWAIILNSSACFSPFFFFCLSVCFPHPYILSVSFLSFVFLFVFFSMVTMVLGGFGGGILYLHSCNLTTYTPAPGTYTNNNNYNYYYNYYYYYIYNLLSDYKKGKNYAARYNLRAREEEAAGKRDESANPSLYPPPLFSHYLHLHLLLLLPLFYAKNYDFILHVTSSSSYRKSGEKKRLFVEAKRKHEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCU7</accession>
    <name>D4DCU7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020958.1">
        <property type="nucleotide sequence ID" value="XM_003020912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCU7"/>
    <dbReference type="GeneID" id="9577810"/>
    <dbReference type="KEGG" id="tve:TRV_04952"/>
    <dbReference type="HOGENOM" id="CLU_102235_0_0_1"/>
    <dbReference type="OrthoDB" id="5315444at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="172" mass="19994" checksum="FCA5CF9889610385" modified="2010-05-18" version="1">MICQYLRKPVPQLYYSEIKKHGFQETPINHFWAHVLPLYFTQDRLCGIELENRSLVEEIRNRAKIKILSVRNGVQGDFFKKVVIISASSWNDITSQLLDYLKVVRAEQKYSGTIYGICAVGSHVSFYSFNFEQQMLESYPDRSNDKRYELLENEQEIDEILGGLANKICEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDF6</accession>
    <name>D4DDF6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglucomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020716.1">
        <property type="nucleotide sequence ID" value="XM_003020670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDF6"/>
    <dbReference type="GeneID" id="9577415"/>
    <dbReference type="KEGG" id="tve:TRV_05167"/>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="5">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="6">
        <location>
            <begin position="74"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38364" checksum="63B5AE2E69B2B36B" modified="2010-05-18" version="1">MSKLCASLGIEGIITVPEQEQPDPDFSTVKFPNPEENGALDLAMKTADNSGVTLIVANDPDADRFAAAEKVKFTGDHIGVLLASHLLDLWKNKKSEKPMAMLNSAVSSNMLSKMAEKEGFHFEETLTGFKWMGNVARQLETRGYEVPFAFEEALGYMFTKVCYDKDGLTAAMVFLAAEAKWKEQGLTPFGKLEQLYEMYGYHENLNTYFVSPDTKSTTSLFESIRKNTLDAQGTIGSFPIHRWRDMTRGYDSDTADKRPVLPVDPASQMLTIWSHRGIRFTIRGSGTEPKVKIYIESCGASRNDAVEAVCDLLTAVVENWIKPYAPAMTYFNSMTTSSGHILKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDP0</accession>
    <name>D4DDP0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020653.1">
        <property type="nucleotide sequence ID" value="XM_003020607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDP0"/>
    <dbReference type="GeneID" id="9577346"/>
    <dbReference type="KEGG" id="tve:TRV_05251"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_1_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="297" mass="33628" checksum="6D0198D48EDF704C" modified="2010-05-18" version="1">MCGQADGLQPRTLEVLKTMGLADPILQDGCYLWEMMVRKPSKDGTIERFSVIDNKVGPARYQRAITISQGIIEQVFDDDLAHHSQRGVRRNSRLVSVSLDEDSDPDFPVIATIETDGVPQTVRTKFLVGTDGAHSTVRKCAGIQLNGESIDDFWGVIDFVADTDFPDIRRFGRVHSRKGTIMVIPREQTVDGDYLTRLYVQMPQQEESEDENPRTEGNGTEPRRSRKSQITLEKIFQKVSEIFEPYYIRPKAGVDINWWTVYQIGQRIAERFAMKDSKGLGRVILAGDCMLSLFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DED9</accession>
    <name>D4DED9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_05506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020388.1">
        <property type="nucleotide sequence ID" value="XM_003020342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DED9"/>
    <dbReference type="GeneID" id="9584147"/>
    <dbReference type="KEGG" id="tve:TRV_05506"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44620" checksum="AF65150C40C22EFF" modified="2010-05-18" version="1">MSPFELLGLTAALWIVCHILLAIYNVFLHPLRKYPGPILDAATQLPYVYHMIKGENSKYIAKLHEKYGEIVRVGPREISYTSASANRTIFGGRPTEETVFEKNPVVWLQGSGEAHNIFFARHREHARYRKMIAPAFSEAAIREQEPVIQEYVTKFIDEMRERSGKACYPDANGVVNIQAWYNFFVFDILSRLSFGTTVGSLDQGDYHPWVTVIFGAIKHSQYVQAAHRLRPYHRLLELFIPKAISEPYDTHMEFAGKTLLERQKGDSIGRADFASFVLKGMSEAELLDNVNILVAAGGDTTAATMTSMTYYLTHNPESYRKLVDEVRGTFQAEEEITVSSVANLKYLRAVIQETMRIHPPVPVGLHRVVPRSGAAIDGRWLPGEVRIHANLLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF17</accession>
    <name>D4DF17_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000323">
        <property type="protein sequence ID" value="EFE39554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020172.1">
        <property type="nucleotide sequence ID" value="XM_003020126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF17"/>
    <dbReference type="GeneID" id="9583941"/>
    <dbReference type="KEGG" id="tve:TRV_05759"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="458" mass="51044" checksum="141B398B94DC3933" modified="2010-05-18" version="1">MGGQGGEGKDDKDKKAQQKEKPKYEPPPQPTTRIGRKKRKQQGPNASAKLPSIYPTSRCKLKYLRMQRVHDHLLLEEEYVENQERIRKSKAQASSTQPSTDDNNSALDRNADERGRVDDMRGSPMGVGNLEEMIDDDHAIVSSATGPEYYVSIMSFVDKDLLEPGASILLHHKSVSVVGVLTDDADPLVSVMKLEKAPTESYADIGGLESQIQEVREAVELPLLHPELYEEMGIKPPKGVILYGGPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQIFQVAAEHAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIESLDPALIRPGRIDRKILFENPDQNTKKKIFTLHTSKMSLSEDVELDEFITQKDDLSGADIKAICSEAGLMALRERRMRVQMADFRAARERVMKTKQENEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF35</accession>
    <name>D4DF35_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000329">
        <property type="protein sequence ID" value="EFE39537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020155.1">
        <property type="nucleotide sequence ID" value="XM_003020109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF35"/>
    <dbReference type="GeneID" id="9583925"/>
    <dbReference type="KEGG" id="tve:TRV_05780"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="75085" checksum="16DCA8CA180156F9" modified="2010-05-18" version="1">MSRLQSAVTLAEDIYFGPSQWDKSSLPSWRQLLFEQCVASVYGSLYHYYHYYYYYDTKMITSLFVAVVFAGAIFLHAIRYQPFSIDPRIYLLVAVLFALGVMVYKILIYPFAVSPLRHLPTPKGHWLLGQTVKQFRANSPHGAAVDWMLEFPEADLIRPLMLGNSESILVCSPRALKEVTQTHCYSFVKPKFLARTSEGIIGKGGICFAEGDVHRQQRRCFNGTLFFSLFEGASYFDLSILTSSVPFLVKNVKKSMPAMLAKGEQLANAVGETAAGNDDIVEGKYIPYARPPSLTSICMRDQANTYTVSSLIIKATIDIISKAVMGYEVDSLADASKAEFYRRTMDVMHLSTTDQIMLALDNFFPARKWIPIEANRRFLHAGNVISELLTDHVRKCISRIKQEPDAEKDLDSDHTDIFTMIVRELIERGDPLSEELLLRTLMVRGHESTANSIVWCLHMLAIHPSVQARLRAAIREVITEDSFTYEAVNSIDYLDCVIKEVTRLYPSCKDKHTLFFLCSIINLYAQLFTNAGQLVVSMLRTPINDIEICGTLVPAGTLLMMYPAVTQHNPTIWGPTVNEFNPNRWNDLPSAAHDPYVYQVFYSGTRVCVGRAFGLLEIKTFLTKLLLKWEFHPIEKELEMPWSGFTLKPTHGLKLRITPAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF36</accession>
    <name>D4DF36_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flavin-containing monooxygenase 1</fullName>
            <ecNumber evidence="14">1.14.13.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dimethylaniline monooxygenase [N-oxide-forming] 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dimethylaniline oxidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Trimethylamine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TRV_05781</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.148" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000329">
        <property type="protein sequence ID" value="EFE39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020156.1">
        <property type="nucleotide sequence ID" value="XM_003020110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF36"/>
    <dbReference type="GeneID" id="9583926"/>
    <dbReference type="KEGG" id="tve:TRV_05781"/>
    <dbReference type="HOGENOM" id="CLU_006909_8_2_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EFE39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="513" mass="57790" checksum="9C20D690439E1B15" modified="2010-05-18" version="1" fragment="single">TCLENGVTDATVFEGRDVIGGQWNYEDPDPETGETASSIYDNVTLNSCRDTSSFSDFPIDPARYPDYFGHRQFLQYIHEYVEHFGLAAYIKLQTKVISCRQQQQQQQRKTGDNPGKWTVVYQQQGHGPVEAVFDAVLACTGTLSKPMIPDFAGRDKFQGELFHSHTYRKPARFEGKRVAIIGFGNSAADLSSEISSVASEVHLITRRGGWVIPRYVLGKPAEAWDSRLFETILPKWASEWCQMKLCEAVVGSLPEEIKPQHSLFQANLTVRSDLLENIRTGRITAHRASIDRITDYGIVLTNGTTLEVDVIICCTGYDIDLPYLLDEYYRMQEKDSVLPARNSLNLYKLVAAPRYPNLFCIGYVHLEGPLVPVAEAQARWAVGAITGKVTLPSPDEMERSVYAYQEELASRMVSSDRHTTIVKYLPYCDDLFSQLDAAPTFWRLFQRIFTSNPVQAYQVLIAVYFGLNSPAQYRLFGHAGKPDLAAQILLRLSKGDNKMTEEEKAYIQSTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFX8</accession>
    <name>D4DFX8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019883.1">
        <property type="nucleotide sequence ID" value="XM_003019837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFX8"/>
    <dbReference type="GeneID" id="9584634"/>
    <dbReference type="KEGG" id="tve:TRV_06081"/>
    <dbReference type="HOGENOM" id="CLU_1219429_0_0_1"/>
    <dbReference type="OrthoDB" id="4412761at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="226" mass="25262" checksum="54C39FE9F47791F6" modified="2010-05-18" version="1">MSKTHGISANIYGRGDRSLGDRPCHVGLAVYEIGSDICEMHHIRCPQDDQYIYDPRTQPLEDSVLRGRCELTQLSNPEKQQVSQILEKFGLDSTNIPEVGVGNCQDWLAGAVKELERHGILPDGEGSYWRNMINLTSDQMKKRCEDDGKQWIDGPGQIPFSGVPDARYSDREERNVGKLAHGSIIEGKLESLFASKSGPGSSAYEDNDPQRLYVSSPFFSQTKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFX9</accession>
    <name>D4DFX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_06082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019884.1">
        <property type="nucleotide sequence ID" value="XM_003019838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFX9"/>
    <dbReference type="GeneID" id="9584635"/>
    <dbReference type="KEGG" id="tve:TRV_06082"/>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="245"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="428" mass="47971" checksum="090429C8FCAA5F82" modified="2010-05-18" version="1">MSVTRPARCLFCTFSKPNLIRYPRRQFHSTPVSCTPRKPKHENIKASDVEGWLKQHTPEKSRPYTEAEKAHMKTVYSPEQIKAIEAGEKAIPDKDVDEQFNLRDDPWALKYVDDFSTIEPVVDHHIRSPITNHDPNSRLKTHDELVDDVANFIKDMPDEPSALSLQKFFENVRLTTGKAEAELDPHSAAVPDVFEPGENFSNIGRHEPPPLFEKEKSFASTSELTDSQKKLMAVTGLSANALKQIQTKVLVSHRVVNQTRLGKIQKAYVLVVAGNKNGLLGIGEGKSEEAPAAREQAEYRAIRSMQPVPRYERRTIFGDVKGKVAGTELILMNRPPVTIFLIVLCSVSLLTTISISGFGLRCSQRIWEMCRLAGIKDLAARVSRSRNPMNTAKAAYKALMSQKDPEEVARALGKKLVDVRKVYYAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFZ9</accession>
    <name>D4DFZ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019813.1">
        <property type="nucleotide sequence ID" value="XM_003019767.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584564"/>
    <dbReference type="KEGG" id="tve:TRV_06101"/>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000194">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="183"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="907"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1434" mass="160979" checksum="5826C889EC96BBF9" modified="2010-05-18" version="1">MTQEVERTPGSSQSKTVRVSFEATADPQASNLGIQPSTSSNGGHHRSATSGAVQFPSSSRSIDDAGQDSHSSANESRPRSRPNINGNRRKPALIRAKSEHWHDLGPDVRALGGEEEDVQLRHGWQEEYTSSEYLKVLNSFLVLTMAALQNFYMYFTEKRHDTNGIPKQPDEVWRSQDWRMRDRLKTVSAALAICLNIGVDPPDVVKTNPSAKLECWVDPTSTTGAQNKVMEQIGKKLQEQYETLSLRTRYKQYLDPSVEETKKFCISLRRNAKDERVLFHYNGHGVPLPTPSGEIWVFNKNYTQYIPVSLYDLQTWLAGPSLFVFDVSHAGNIVQNFHAFLEKHEKENAEARKRDPIASLQNYGDCILLAACEKNETLPTNPDLPADLFTCCLTTPIEIALRYFVLQNPLQTSLCVDEFRVPGRLQDRRSPLGELNWIFTAITDTIAWNTLPRPLFKKLFRQDLMVAALFRNFLLSERIMRTHECHPISSPKLPITHTHPLWQSWDLAVEMVLAQLPALIEQEEGTRHYEYQHSPFFAEQLTAFEVYLSSGPTEKNPPDQLPIVLQVLLSQAHRLRALILLSGFLDLGPWAVHLALSIGIFPYVVKLLQSAAQELKPVMVFIWARIMAVDHTVQNDLLKDNGIHYFITILHPNSPIPVANVSDHRAMCAFIVAIFCKQYPQGQHVCLSPELIEACLTHLLDTENPLLRQWSCLCLSMLWNDFPEAKWMGIRASAPPKLCELAADPVPEVRAAMLHALTSFIGIPDLTDQVAQIEEYLAMAVLPMGSDGSVLVRKEFLVFVSTFVKRYQNKFIVAAYEQLLEEKQVLTTQPTGSPLMSPPQPSENGVSQGTVIGSIWKLVLILSVDPHPDVAQDGGIIVDYVHKTLLESPLGGLARKAREDILELYTRAQSKKTQQQESIDNARPKTPPSQQAPKPEGYLSLSLRRTASVAASLKNMAFGSSSNSPQPPGSPNSTTFAKPQVPKGRVTVTPRGRAPAEWTRPPEVNDQRASARSYQQAPTPSSRGFKLRDVKEEPVIPLVSQFLDWSTEYFREPQMKPNEPDEPGSSDYNERLWRRGRNERIIVETQPMKTRAGSSRWDNSVSLINNSTQPMKMCFHQFEDHLAVADDRDTICIWDWQSNTYLNRFSNGNPLGSKINEVRFINEDDQALLMTGSSDGVLKLFRSYESSKNVKVLTAFRALPELIPSNKNAGLVLEWQQGQGKALVAGDVKVIRYGYTLQPIVHVITNSQIQDISARSGSCITSLTSDQVAGNIFVAGFGDGAVRVFDQRLKPTTAMVKVWREHKQWITNVHMQRGGVRELVSGSRNGEVRLWDLRMDHSIESTQATKDTLRTLGVHEHAPVFTMYVCPYLINPFGAKLTCCLLAEPIAVKSRHSMLTALIYLPSNLIAAFCTIPDPPQSSALYSILIKCSWLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG15</accession>
    <name>D4DG15_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019829.1">
        <property type="nucleotide sequence ID" value="XM_003019783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG15"/>
    <dbReference type="GeneID" id="9584580"/>
    <dbReference type="KEGG" id="tve:TRV_06117"/>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="165"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="622" mass="69913" checksum="0BD7077215E772AD" modified="2010-05-18" version="1">MVSKILCVAEKPAIAKGQTNIVLYKSGIEGNQYVKNYEFDFTFGPPWGSCSVVMTSVLGHLTASDFEPRYRNWNSCNPSQLFAANVIIAVDKEKLGIARNIKRQARDSRALFIWTDCDREGEHIGSEVRDQAVLGNPSIEIKRARFSNTERTHVLEAARRPTGLDERQVDAVAARIELDLRIGAAFTRLQTLQLQTLGGALAEKIISYGSCQFPTLGFVVDRYMRVKNFKPEAFWSIKVSHTRDGITVNFNWQRGHLFDRAAVVVLFERCLAAKIATVTKVNKKPTSKWRPLPLTTVDLQMMGSKYLRIDSQAIMKFDNEIDLKKLVEKQYPSEAWGEYARGSVFSTNTILAEFHTNPSRCGGFKQPRRGRNNDKAHPPIHPVAYVSPTVLNANEEKVYEFVTRRFLACCSEDAEGESTDIEIQYGDEEFHTRGLVVLERNYLDVYVYDKWESSQPLPNFVLNESFEPKEANITEGKTVAPGYLTEPELIGLMDANGIGTDATMAEHISKIKAREYVATRPRGGGRGSGGRVDEFIPTKLGVALVEGYDNVVAGLPDCPSLTKPFLRKEMELRMGDICSGTKTKAEVVRQNVGMYSEVFTHTQQRIELLKVACRKYVFDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG44</accession>
    <name>D4DG44_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000346">
        <property type="protein sequence ID" value="EFE39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019801.1">
        <property type="nucleotide sequence ID" value="XM_003019755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG44"/>
    <dbReference type="GeneID" id="9584552"/>
    <dbReference type="KEGG" id="tve:TRV_06146"/>
    <dbReference type="HOGENOM" id="CLU_007593_1_0_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="893" mass="98706" checksum="5ADB346C2D51D776" modified="2010-05-18" version="1">MSAAQRRLADQPSFFAAFCVCWLRFDQPPPAPTPASRRCRRQTSFVRLLILLPLLLLLLLLLLFFPVFRRPFLFSVRRPDLGPLSAGVDLQHPLQPAAAATSTTPSTPAAPEDTRERKPRSRSSRDQLIFLPARDAARLAGFHVDSTISTSARPSRQRQRRHQRRAALLKTAGQSPSPDQKHPHTQQTQQRPTPRRQLTLDSIEQRLEDTQKEGPRQDSRQGARQGSTRQGTASSYWPAQSIRVSPSTTSAILWVLEEAIRTPYPFTADPAELNASMSELFETAPADVANGRSSQHHHHNNGVAVAAGRNGMVPAPSTTGATHAPSGVRTPTDIMRRRRERERAQLKAEQEAKLREEQLQKQAQLQLQAQAQVHQSASIITVSQDSGQRQSGRQDTVRIVADDTQKPARQRPNTSQAAKMASGSQQQQQQQQQQQLPDSSSKPQASQSAPGGQQEPQHQQQQQQPSRGKAAFPHAFERWEMLSSHWEGLTSYWIRRLEQNNEELSKDPLSQQMSRQVTDLSAAGANLFHAVVELQRLRASSERKFQRWFFDTRAEQERAQEVRAELERMLSSERQARADAIAALKQAESDKAKAQELAREVRRELQISRDEARRAWEELGRREQEERDRTISLRNGEPTIVGGVQVVPMLQSVPSRHTSTANRPPTREGPYPGGPSATSMGGQSQQRPLLETTESTGYDDDGHDADPFIEAGNPPVVPEAPQPPRQTESGRGHFYQHNRQAIHGGAQAGVGDVLSEDGRAPTTTVGGAASLTAPIAVTNGGTQHVSDGRQLSYPRAMSDDSDDYTTEPFDNYVTYGSGPHGSPGAGTSSADDSHIGYPAPVDYSGSGWGVGGSGWDSVTPRHRHPTRLSDVLEEDERSRTSPSRASQTSRNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG71</accession>
    <name>D4DG71_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000347">
        <property type="protein sequence ID" value="EFE39172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019796.1">
        <property type="nucleotide sequence ID" value="XM_003019750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG71"/>
    <dbReference type="GeneID" id="9583719"/>
    <dbReference type="KEGG" id="tve:TRV_06173"/>
    <dbReference type="HOGENOM" id="CLU_686196_0_0_1"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="42524" checksum="B6E40F4D6B032CB5" modified="2010-05-18" version="1" fragment="single">GRATWMAIYLSTGRAPAAAGWLAGSLALLAGAACWAALRESEGCFLVSSSSRQGAKPGKRAGNSTLVNSLIMEWRRKDEQATKAAGDDESDDSKGLLTPQLFVRSRWQSTRQAQQREKPAQADGQRDSDESHDASLSDPDLDGPHAHLLQEARRCGAGQAAQLPRPRYEQGDGDLGQVGDGREGLAEDAGHLRPPGAAADPLRGMGAQERAAAELTAGDGRAAGAQARRAAVPQECDQVEQGDGPAAAAGHGETAAAPQAHVVEHRRCALDGSVCAGTGYLIYPFSSSATAAGRTGEADTALGGSKHLEFLLKENLIRPRSLTDLENVYLRHYPRKDGVEDTTADEKTAPDCDDGNCGKEVMLLKDTDGKALAKMLDAPELVAEVERAVHQVQQQLDQKKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGI8</accession>
    <name>D4DGI8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019663.1">
        <property type="nucleotide sequence ID" value="XM_003019617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGI8"/>
    <dbReference type="GeneID" id="9583580"/>
    <dbReference type="KEGG" id="tve:TRV_06292"/>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="230" mass="26096" checksum="A2D81C51ABD71418" modified="2010-05-18" version="1">MAREDAQSVHYHYRTKAEVPWDIQNYWAQRYKIFSKYDEGVWLTDDAWFGVTPEPVANKIALHMAQAAPETKCILIDAFAGAGGNTIAFAMSNRWKRVYAIEKDLETLKCAKHNAELYGVADKITWFVGDCFELLQNQLKDLAPYSVIFGSPPWGVFNLSTMEPYSLEFLHAEFSKFTRDVVLFLPRTSDLRQLAATTAPGKKSLVMHYCSEGASKALCIYNGDFKPIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH03</accession>
    <name>D4DH03_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000366">
        <property type="protein sequence ID" value="EFE38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019521.1">
        <property type="nucleotide sequence ID" value="XM_003019475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH03"/>
    <dbReference type="GeneID" id="9578210"/>
    <dbReference type="KEGG" id="tve:TRV_06458"/>
    <dbReference type="HOGENOM" id="CLU_2575582_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="81" mass="9370" checksum="939D367033710993" modified="2010-05-18" version="1">MLTVTPGQAKLVAYMMPFSFFFCFLLNEKSNPRVRDEDKRKKGTVGAFSIQPRQRDKGVEVESTRRKMPIPFLKDEEDEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH20</accession>
    <name>D4DH20_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000368">
        <property type="protein sequence ID" value="EFE38851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019496.1">
        <property type="nucleotide sequence ID" value="XM_003019450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH20"/>
    <dbReference type="GeneID" id="9578188"/>
    <dbReference type="KEGG" id="tve:TRV_06475"/>
    <dbReference type="HOGENOM" id="CLU_018409_1_0_1"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="56158" checksum="65BD47D9CEDCD697" modified="2010-05-18" version="1">MANGTVGEEASTPPSPKASSRKPGQEAAANGHIQGDQTSSKAGDGADHEDGDTAMTSDAPVAADKQQPEEAHSKIPKSPSRPSSPAVEPVVDADGDIGMSAPPTPVYTLTNGQSVGVQIAPPKAIDLTTDTILLDIGAKNHVMKTAWRPGDSLLVGASAESYCGLWKLTGQRSSTTPGHEVLTSTANVTAMEWEPTGKTLAVATYSDFEGTVVLYGPQGKMIKTLPCMPGLISGLRWSGNRDRIIFTVSDGSQSKLLLWDKEISTTEYINSQLIDGAIYEVLWVEDEEVYACGDGAVYQFRVTNEIELSETFRWEEYPQEPWTLIKSIQWKESSVVATVSTSATTSNIWIPSHDIKVESAHHGIITSLEFRPLPKPHSSPQTLANGTGKDPALILATSSMDETLKIWSIDCTSRTASCVHRLFLGSSLPALSSAFSPDGYAIAAASQDKLFIWNAERGGTPMASWPIPKDGTKDETNSDEGNGTVNGIQSALDRPLSWDSDGKKLALGFGNTVCTNSITLPYLISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH62</accession>
    <name>D4DH62_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019437.1">
        <property type="nucleotide sequence ID" value="XM_003019391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH62"/>
    <dbReference type="GeneID" id="9577887"/>
    <dbReference type="KEGG" id="tve:TRV_06517"/>
    <dbReference type="HOGENOM" id="CLU_2605562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="8126" checksum="C2F5F3B1C64EF77E" modified="2010-05-18" version="1">MRVFRRHSGSASASITSIGQMEAETVGRLSFDEISNGGLLSAEPGHGLFGVVSGSGEGESQLPARRQADIAGKVGLPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH74</accession>
    <name>D4DH74_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall biogenesis protein Mhp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019449.1">
        <property type="nucleotide sequence ID" value="XM_003019403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH74"/>
    <dbReference type="GeneID" id="9577899"/>
    <dbReference type="KEGG" id="tve:TRV_06529"/>
    <dbReference type="HOGENOM" id="CLU_004016_0_0_1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1239" mass="134340" checksum="E5C9AE0C370107EC" modified="2010-05-18" version="1">MEGGAEAVDVSWLHHSQRADTAGRSKNTPSRSSQQKLNEQQPGTDSTATQNDATASTTNGQNGQASASAPKPVPTSSLSKPLPLPSESAENETSKQQSLSPPNQNQNQIQAQAQGQGTGPEYTPAPNITTSAIALTGTTQTTVTSTNASTRTPPKPVPRRNSWISTLSSKFSSGSTPPSQSHMRESPSTGRQQQPSDSINPFGAAYSPKDADKSGEGSSSFTSGSPRSGHPSFFHNAFRKLSSSGGASLGKLSSNYAPNGGVWPRRVMNVDADRDRCKIPELNQAKLRRVAFCVDVEIAGTQRRSEGDEERSTKKKPDPKAVEAEEGTVLKHAAGHAPLPTSSPPSDAPVSNGAVQPPDSHPIDDEKSKPPPTKKQEKKKRSEEERKERKEKKRRQAEENGSIPLQVNLEGGSNSTSKTNSIRRSSRGQDQPTTDPLRIYRRCCQLRETGVLKKLVEQISSPSSILAESPGTVAVLDLTGFPMTLTDIITFSDWLSIVPVRKLILQDCGLSDEAVRVILGGLLATKTIEAARQARQLKHRNVGSELAKEIRYGAIEKLSLKGNSKIGPEGWRHISLFIHMSRSLRGIDLSGIPLPRPTPPTNGPASPISRPSKPVPDIGTIFANALAQRFGGERLEELVLSECSPSTEDVQKISDAARSMGLRRLGLANNDLTKEGLEYVINYFQGGKCEGLDLGGNKLEAHIGLFSSALDKTFPLSALSLADCSLTPKTLCSLMQGLTLLPNFRFIDLSHNKDLFITQPDSLGILRRYLPQMKELRRIHLADVCLSSEHAIALAEILPDCPKLCHINILENPAIQDLASASTPEAQEEACALYASFMSAARISRNIIAVDIDVPTPENNEVVKALASQIVAYSLRNLQYGELKEELSSSADTQAAVKDVPVPDILEHLVGHADDANGEIDDSKVTSDYDYVIGGTGVVKALGICLGNSDYTAVEDVLGDQSPTASGTSTPYRRLSHVRVTKKPRDMSRDLLNSARKIRLRLRPALVREDRAGNDLNYRRLHFLDMTLQRMIQRFEDEFPDTRIPDETSTTRSSDGSPNLSNVNDSTILEPVGSSANGNTTAEADGEDEDVDRYAVRLSRTSSNTSLHSRALTSEEGKVHRLSHHFSHSLLGRSDKDKSKDADQESSEKPISQSPPDAVQVQALREKLERLRALQGEDTDTNVHSEDPSSSSRPILHDGASNLEELLTLQKQDPEAFAELKESHIVALINAGLRNPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI47</accession>
    <name>D4DI47_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000395">
        <property type="protein sequence ID" value="EFE38471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019116.1">
        <property type="nucleotide sequence ID" value="XM_003019070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI47"/>
    <dbReference type="GeneID" id="9582607"/>
    <dbReference type="KEGG" id="tve:TRV_06855"/>
    <dbReference type="HOGENOM" id="CLU_040577_0_1_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="402" mass="41364" checksum="15D72E0AC881457D" modified="2010-05-18" version="1">MLRQFHYIDPNGKDQGINIRNRSQELAKLLGDVDMIRAERKKAKANRNKFGGFEGGIGVGGFSGGGGSSRFGGFGSEDANFGGFSGGVYGDGGGFNGNTSEFRDASRRSNRFEEYDEGDNSGYSAPRRSEPTSRAESKPAPPKAPTPDLVSFGDDDEVVAAPSVSSPPAKTSSTTKPVGSSGLTELAAQSMDDDEFDDFQSASPTTPATNTLQSQFGSIAPPSAPTQTQFAAPKPVSAAQNASLNGLAAFRSNPQTPSATGTTSQGSSMGPLSPTTQSQPPKPTTYQASQPNYFTSIPTPQPKPLESSNKSTTKSQTTGSSKSGGDAFGSLWSTASANAGIKSTTQTQSKGPNLASMAKEKASAGIWGTPSSSSSPQTFSGTSSSQQQKKPSGGSALDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIM0</accession>
    <name>D4DIM0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protein DskB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019017.1">
        <property type="nucleotide sequence ID" value="XM_003018971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIM0"/>
    <dbReference type="GeneID" id="9582422"/>
    <dbReference type="KEGG" id="tve:TRV_07030"/>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="50575" checksum="772E5F6CC989AB79" modified="2010-05-18" version="1">MAEEDAPFTFHVKSSAEPKFSLTLKPSSTVAEIKQILAGEEYANVPPERQRLIYSGRVLKDSDTLASHKVKEGHTIHLVKSSAPAGSSSSGSGSANTTAAGSSSNTTASSAAGRGAQSTPSGAAGVPTNLAAGTGNSMLAGLTGARYAGFSQLPGAGMFGPDGGMGPLPDTDQILSMMENPQFQSTMNEALQNPQIIDMMIQQNPMLRDVPNARQILQSPEFRRMLTDPNMLRYMTQMQRAMGQGGGGGQSAFPAPGVTNTTQRDAGSQDNTTTSSNHNNNNQTQPQMPPFNPFLAMPGAGGNPFSFLAGMQQPPAGAASGDAGTAGSNTTNNSGSSNNNSNNQQQRQQQQHQPNPFASLFNPALLGQLPNADGQPGQPIPNPFMQNPALFSQLMQAMGGGPGADANSNPNPNPNASNPLLHSLFGGQPPQPPDNRPPEERYAEQLRQLNDMGFFEFDRNIEALRRSGGSVQGAIEYLLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ17</accession>
    <name>D4DJ17_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">TRV_07182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000419">
        <property type="protein sequence ID" value="EFE38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018801.1">
        <property type="nucleotide sequence ID" value="XM_003018755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ17"/>
    <dbReference type="GeneID" id="9581198"/>
    <dbReference type="KEGG" id="tve:TRV_07182"/>
    <dbReference type="HOGENOM" id="CLU_004096_0_0_1"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="995" mass="109647" checksum="EA5364BB20C99D74" modified="2010-05-18" version="1">MVSLLKQPSGASRPEWQKFLRQCLLQRISADEFHNLAKVMLRRHPISHMDLFDVILESRAVTDFDWDPLIPDYVDAVQKLTQVELFNILPSLLAHSSITSDIRRWKKQNEAQNQDMDQKVDEKGSTEPADSKGPATLLTDYGIIQNVITAVTTGHAPKVPLEFMDTCSAIADWILALVSWNAHLGSEKGEGSGTQLLATPDVVSIFIAVGFLFGALAGTEVGANALSFQHAGTYSPICAEISIPLRNRLDQLQKEFSLFLKGEKSNQDHVIEDTAVSTLEFESRVVDIPPVSSRAGLYIYVNSLGNHMALVEELIAASFDVLSNGMYRNEPQQSMFLFRAFLVNKLPPFLSDLAGSVVEPIPVELCITRALARVDPNTFPSFSEIFSTHGNSVLSDVRQEFLFSCALHKLIPESSIERLLGENPMQTLPNGGRLVKHDLVAQINNNHERAEQLLNGIESMDGNARAIVEAIAETLDIMLLFKSPQAILQPLCALLDSWKWEEDQGESQPVYDEFGSVLLLVLAFKYKYDLSYQDLGIFNPDSFMCRLLEKGSSSQKLEDLTEKQQQNLGAWVTALFIAEGISDESMSSCSPQEFYLLVATLFCQSLSACEAGKLEFDTLKEPFLLPSLVMALSWMGKHIWKSGTDLTTTLKLLATLVKPTSISGEAQEIHRTVLSITARELADELRTAKARHPSRTDIEPILQALEPYQSFQRTGTSNRSELEGWRSSSAPGGMVTGIRNTFSSLVLWSTDPEISMTPPSYTHRQLSAGLKHLGSVRVLAGILEELKLQSETGSGDLAIDIAATLICAPMRECFSLEQAAYQSVGGSLKDSLPRRQMLNLRDALNLQRESLSKMIEYEPHRAELIVRLARRVDTITSIPQIPQGVENIDVGNIMANMDLTGVEENGQMQIDVAQQAEQQDQQHQNLTATGTDATPGTIDAILDAATAGVTAPPAGTEVTMAHSDMDASIFDDMLNPTDMGVGNPEFIDLDMEGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ46</accession>
    <name>D4DJ46_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018776.1">
        <property type="nucleotide sequence ID" value="XM_003018730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ46"/>
    <dbReference type="GeneID" id="9581172"/>
    <dbReference type="KEGG" id="tve:TRV_07211"/>
    <dbReference type="HOGENOM" id="CLU_1053654_0_0_1"/>
    <dbReference type="OrthoDB" id="4174361at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="271" mass="29136" checksum="68D8342D64ABE24D" modified="2010-05-18" version="1">MENESEKSPAGAASRQEETHLHTTTSTTARSTITAPEAEPAPGPTPTAPAATSEDSPSPVPPPPQPQPFPSPYTGQSTSWTGASVPPQETPNAAKPIPPPPKASEMHLYKESTTTTKPPSAHIDTQTHAQHHHFQTLPHQHQRSASSSSHSNNTLPNLEHPPGYRQNPAIAQPSPATLAADGAGFGTGEGPHFGMRQVWDPAPGEAGGRYVYQYDFFGDDEDRNDQAADDGEWLWNSAAGAWETTLSWMKSAGERMAEAEEGIWRWVNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ64</accession>
    <name>D4DJ64_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000424">
        <property type="protein sequence ID" value="EFE38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018754.1">
        <property type="nucleotide sequence ID" value="XM_003018708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ64"/>
    <dbReference type="GeneID" id="9581148"/>
    <dbReference type="KEGG" id="tve:TRV_07230"/>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="221"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="44821" checksum="4AF6EFEBAB692988" modified="2010-05-18" version="1">MPSPSAHASPFIAPRPFHPHVTEFPLTQDTAIPLPSSSFAGGSSSSTGSRNIDADGYTTPNSASTPALLPSIISPALSPTSTLTSTPDVTSASPGSSNAYPAIITPRANLEDQHTLSKPPRLLQHLPKVECIVRARIPTTSGAEMFLHLYQNDADNKEHLAIVFGNSIRSRSLDRVREGETEMDRMIRGAYVGRLRPGRQSSRYDEAIPANDTQSPKNTSVQGPSQAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSEPDTFASGEDTNVSGPGGVIVYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAILVDLGLGQDSSNGGIRLLTNNPDKVAAIEGPNREVIVQERVPMVPLAWKTGGARGIKSVEIEGYLRTKVRQNFSTDSSLLYLNALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJA8</accession>
    <name>D4DJA8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000430">
        <property type="protein sequence ID" value="EFE38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018710.1">
        <property type="nucleotide sequence ID" value="XM_003018664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJA8"/>
    <dbReference type="GeneID" id="9581025"/>
    <dbReference type="KEGG" id="tve:TRV_07274"/>
    <dbReference type="HOGENOM" id="CLU_009827_0_0_1"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="628" mass="70275" checksum="D0C9821BCE76C4EA" modified="2010-05-18" version="1" fragment="single">GADCHYGEDKSNLIDQSAPTTSAETKPWSMPPDTKGLKRTHDEMSSASPARNLMEIPQVASKENLVKPTPKAEKEQGYRHGPGESVHIVGPVAAADAQVIERYSERSNNHSPDRKTPYNVYSNDPRKPILYTTVSRRRQGLRTTGTPGENQREIIEQVLGPFKHDLVKIFLDKINASFPIFDEEAFLSGYEAEDDSVPPALLCQVYATSLIYWNQSPVLAPHPKPDVRYAVNMAVAALHEEFSAPGLSTLTAALIDLTGRPIFSTTGNAINSGRTVALAHCLGLNRDPSNWKLSRAEKNQRIRLWWGVVIHDKWASYGHGVPPHISRNQYDVPLPTISVLVPHANPTQQRVRTAHCYIALCQLTEILGDLLPLVYGLQPRPSKETSKILRRMRSDLDRWEDSLPDWLKVPQDQDTPSTSGASSMQLAFLALKMLVCRVELQEVNPSDNPNTEARRYFQTECRKAAEEIVQFMLSLRKPQYQEFWMSSTLLVRSALETSDPEIARSCLNNVSILRGVLEKARSENDWDVGDMCLDHCEKILSKHTTEEVVQASELNRNATINHHGSDAPETVVMTPYDRANHNDIVDDMMSISGTFGTMDGFPFDMTGIWDVSGLQDQDTNFINMTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJH8</accession>
    <name>D4DJH8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018656.1">
        <property type="nucleotide sequence ID" value="XM_003018610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJH8"/>
    <dbReference type="GeneID" id="9580809"/>
    <dbReference type="KEGG" id="tve:TRV_07346"/>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="917" mass="104410" checksum="14E4BCF855C5EAA4" modified="2010-05-18" version="1">MNPHQPASPSRRYQGGYQLEDNPFHQPVQQPMTHLEMPSADRLQYQPTYSVENIQNSYGHNEAYEEQHPYRPSPRPVAAGTGPLALSPEAHHDAYYTQPYEPAATPPDDYDRQHQSYPPRQYDDHVPILHHEPSYTPSNFDLSHTPHPVDTDGYTDDPNMALNVAPTPSPAPIRRWKTVREVQLFNGNLVLDCPIPPKLLSQINHAEPPERDEFTHMRYSAATCDPADFYQERFTLRQRLFAKPRHTELFIVVTMYNEDEFLFARTMAGVFKNIEYMCSRTSSKTWGKEAWKKIVVCIVSDGRAKINPRTRAVLAGLGVYQDGIAKQQVNGKDVTAHIYEYTTQIGMEVKGTQVILKPRPGMPVQLLFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLIDAGTKPGGRSIYQLWRAFDLEPMCGGACGEIKVMLSHGKKLFNPLVAGQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGQGPLEKYFAGEKMHGANAGVFTANMYLAEDRILCFELVTKRNCQWILQYVKSATGETDVPDRMPEFILQRRRWLNGSFFAAVYAILHFYQVGRSNHSFTRKLMLIIEFICQTINLLFAWFAIGNFFLVFRILTASLGTPDLLGKAGSILGVIFEWLYLATLVTCFVLALGNRPQGSNKFYMTMVGFWCMIMIYLTFAAIFVTVKSIQNEAREGKFTFATLFQNLQFFSIFVSLLTTYVFWFLASILFFDPWHMFTCFLQYLLLTPTYINVLNIYAFCNTHDITWGTKGDDKPEKLPSAHLKPGGKVDVEIPQDDGDLNAQYEAELAKFASKPPKETRVVSESEKQEDYYKGFRSAVVLAWIFCNFALGAVVLSAAGLERVDANSKDNSQKRSIIYMAVVLWSVAGLSLFRFVGAMWFLVVRMFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJN2</accession>
    <name>D4DJN2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018555.1">
        <property type="nucleotide sequence ID" value="XM_003018509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJN2"/>
    <dbReference type="GeneID" id="9584484"/>
    <dbReference type="KEGG" id="tve:TRV_07400"/>
    <dbReference type="HOGENOM" id="CLU_108989_0_0_1"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="180" mass="20053" checksum="5B45E4B3227CED7B" modified="2010-05-18" version="1">MNTDTETEDRSGTPVPGSSLDPDSPMVDSPIYPRSPKINMASREVEEEEEDDDGEAFITVAPASVPASPTKETVIEAMVEPRTEPRPRPRKSLIPTPKSKHVPKYIPKQTPKQTNKPSPRKDDGLSGLAHELAGCTWEQLQQRFTEEMDERSKAENILQKETADLLEVSLATLLQFNVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJN8</accession>
    <name>D4DJN8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000442">
        <property type="protein sequence ID" value="EFE37916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018561.1">
        <property type="nucleotide sequence ID" value="XM_003018515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJN8"/>
    <dbReference type="GeneID" id="9584490"/>
    <dbReference type="KEGG" id="tve:TRV_07406"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF8">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="81"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="582" mass="64166" checksum="275FC964796E95CF" modified="2010-05-18" version="1">MVKEPEAWEEKAAVKRAVTVAKIPEEWRLTEEQINDAKAQRQLAGAYFQGFLTDEERKITGEESTEIVSKIKSKEYSALQVAKAYCKAAAIAHQMTSCLHEVFFDQALERAKYLDEYVEKHGKTMGPLHGLPISLKDQFHVKGNDTTMGYVGWIDTFEGDKGSHKVHNFDSPIVTDLLSLGAVLYCKIGETENHIIGRVLNPWNNNLSCGGSSGGEGVMLALGASSAGLGTDLGGSVRVPAGFCGVYGLKPTHDRLPYRDVANTNPGQNTYSSSIGVLSTSHDSIQLMMKSILSTQPWLRDPVVFSVPWRDEIVAETLERVAPDGSAKSDQKSLKFGILYTDNIVTPHPPVTRGLHALEDALKKAGHKVVSWNPPPHSTAIRIHLEFMSADGGNDIKKQLSLSGEPPIPQIKIFVEGKEPLPLLEYQDLILQGIEYAEAYADYWNSTAQDDGQIVDAVIAPLAPWAAVIPTKYYHTGKILHLILTRHNTQFLQSPAYTEVINLLDYSVSVVPVTKADKNVDVADPDYEPISELDKANWELYDPELFNGTPVGMQLIGRKHEEEKIWAIGKIVDNIMKKAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJU8</accession>
    <name>D4DJU8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018520.1">
        <property type="nucleotide sequence ID" value="XM_003018474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJU8"/>
    <dbReference type="GeneID" id="9584449"/>
    <dbReference type="KEGG" id="tve:TRV_07466"/>
    <dbReference type="HOGENOM" id="CLU_1495825_0_0_1"/>
    <dbReference type="OrthoDB" id="4203691at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="175" mass="20247" checksum="4173162C83A00078" modified="2010-05-18" version="1">MASKALKYTTELFNGCSPTYKRLLTMTAEGNNPHVTFPFKGIKLPRGTKEHCPFTDLEEVRNSVTIQFLGTPYGNITAHLFNDGTIKTSTMMHQENNRRREHEARLLAEENKFPHLNQTPLRTQAYNRKMAKIRNARDNSTWSIMKKQLEKATAEEEYSRFLQEQAEQRAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK50</accession>
    <name>D4DK50_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000452">
        <property type="protein sequence ID" value="EFE37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018417.1">
        <property type="nucleotide sequence ID" value="XM_003018371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK50"/>
    <dbReference type="GeneID" id="9584345"/>
    <dbReference type="KEGG" id="tve:TRV_07571"/>
    <dbReference type="HOGENOM" id="CLU_020129_1_0_1"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055595" evidence="1">
        <location>
            <begin position="25"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="629" mass="67374" checksum="F341759EAC116803" modified="2010-05-18" version="1">MSARIISRTLKVISLLLLLQGVDAVTFFSTGTTVVLDDTHYYVPPDAVGRIPGNATGDSGLLPISVISINASSAFGLHDLQARIKRFSLEDDVFQVGFAEGNICSDHAAEKRNRAIGNHTVLSSSSHHNETTALPDGPYVVSALGCLHQVYRLYADVQSAFSETTTINADGSFSVLPANVPGQSLAVAVPSRLYYRQTAQKPLAGVRLGVKDIFDVKGLKTSNGNRAWYQLYPAANRTAIAVQNLVDAGAVVVGKMKTSQFANGETATADWVDYHAPFNPRGDGYQDPGSSSAGCAAGEEIRSQAAYPWLDIALGSDTGGSIRSPSQLQGLFGNRPSHGLVSLEGAMPLAPQFDTAGLIARDPRLWAAAAKALYGAKIKMTKSYPSRILAVGFPTEPKSNLDVLLLGFVDRVARFLSAHVEVFDVAAAWAATYPRGSPLAAVVNNTYEILSAKEQARLVRDVFYADHAAAHGGRLPHVNPAPLNRWALGDNSKATIAEAEANKTRFMDWFNRSILPSGNTSCSENLLLYMPRIPVPKYRDTYRSGPALPSAFNTSRISVMSGTPDMVIPIGQVAYRSAVTNHTEYLPVTVDIMAAKNCDGMLFSLIEDLFVRGVVNVSNVGSTIETGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK59</accession>
    <name>D4DK59_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical pathogenicity factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018386.1">
        <property type="nucleotide sequence ID" value="XM_003018340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK59"/>
    <dbReference type="GeneID" id="9584330"/>
    <dbReference type="KEGG" id="tve:TRV_07580"/>
    <dbReference type="HOGENOM" id="CLU_2160245_0_0_1"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="111" mass="12639" checksum="9419DFFF3EECFB8D" modified="2010-05-18" version="1">MQAWGGVESFDLTLRRRERLPPTTTTTTTTSPAATSTSSKKSPKNIPRPVPDWLHDCVGPNKSFDEIRQLINDLRLHFLSLVQNNQEPFFPDIEILPNLRRSSKKPAKQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK60</accession>
    <name>D4DK60_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol binding protein (Orp8)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000453">
        <property type="protein sequence ID" value="EFE37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018387.1">
        <property type="nucleotide sequence ID" value="XM_003018341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK60"/>
    <dbReference type="GeneID" id="9584331"/>
    <dbReference type="KEGG" id="tve:TRV_07581"/>
    <dbReference type="HOGENOM" id="CLU_342955_0_0_1"/>
    <dbReference type="OrthoDB" id="4171886at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="93046" checksum="D0F4C419E76AEAF2" modified="2010-05-18" version="1">MVVADEEKKKREEEEEEDEERGIYMLKRERERASPEVKTGGQQAASSNTDRQTGERKEEKRRRRREEEEETDLSRTVLNLCPSSIFSQSRVPQGIQHPTRERVNHHINPLRLSPSSTTPKNAILTTTAGARPGGEDSWWREEKRKKRREKKKKKKRGREGGGGEKPPPFYRLSAGCLVVDESQLTSHRHHHHHLLLLTVLLLGKRRRRESEGQKDRRDRSGRREIEVDQGDIKDRQLEDKRQETGDKRSSSSSSSSSVSSFYLFISTSLLLLLLLLLLLLLMSSVSSSADSKMPKDDSLVGGGGGSGGGGDAATSTTSTTSTSTPPTTDLPDKPVDDSSKLRAFLSILRKDKDKDTDSDSFIGVSDIASVRFSLPAQLLEPIPNLGQSPHFYTYIYIYIYIHTYLWIEYWNYLDRPESFASIGKSDDELGRMLEVLRFWFTKDLVGLLLFSTYLLTCLPIEKKYVKGKPCKPYNSVLGEFFRCNWEVKDTEAAVSLPPAKPESSSNSKSNSAAPSIASTSATTTTTTTSSSSPSAETVKISYITEQTSHHPPVSAFWVDCPQRGITARGFDQISAKFTGTSVRITPGQHNLGIFITLARRDNEEYRLTHPDAHLGGLLRGALSVSVADTCYITCPRTRIKAILQYLEDGWLSKAQHRVTGAVFRYDPDNDCITRIKDIPATHLLAEISGSWHERIYFNLPSNPKDKQLLIDVTPLFPAAKITPPPEKQLAYESRRLWADITAAINAKQYSLATRLKHELEESQRSKAALRKENNHEWTPRFFTVAEQHIQPGRPHLTDDGRKALDNLHRDLFDLDEKLTPSGEFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL45</accession>
    <name>D4DL45_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018083.1">
        <property type="nucleotide sequence ID" value="XM_003018037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL45"/>
    <dbReference type="GeneID" id="9579292"/>
    <dbReference type="KEGG" id="tve:TRV_07919"/>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE37438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="286" mass="31521" checksum="C4071A2EF2658102" modified="2010-05-18" version="1">MKRKKSLAQGRPPTVKKPAASLSARATRDLIRSHHQLHKARARAAAEGNEELVRQLDSEIAAKGGLKSYQIASKKGQSKERGGDSSHVLLQWLKPKLLGGIQGQPENGTGKLRVLEVGALSSRNACSMVKALDVTRIDLHSQEAGILQQDFMERPLPTTDGDRFHIISLSLVLNYVPDPAGRGEMLRRTVEFLTSSVKDDVLPALFLVLPAACVLNSRYLTEERLDDIMASLGYQQLQRKVSSKLIYYLWRYTGVHVRTKGVAFPKQIINPGPGKNNFAVVLKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL95</accession>
    <name>D4DL95_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HMG box protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000497">
        <property type="protein sequence ID" value="EFE37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018017.1">
        <property type="nucleotide sequence ID" value="XM_003017971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL95"/>
    <dbReference type="GeneID" id="9579151"/>
    <dbReference type="KEGG" id="tve:TRV_07969"/>
    <dbReference type="HOGENOM" id="CLU_1375213_0_0_1"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="199" mass="20950" checksum="CDA0D2ABEF76F107" modified="2010-05-18" version="1" fragment="single">KWKDLYAQNLAVYNEEMSAYKASLPPGHKVDSTVPATPKPAKAAKTSKSSKPSTKEAARHQDDHDAAAEQQLQQAVREATTDDTSSESAGSSESEAEATPTPSPPKPTPKSSKRRQSKAAAAAAAPAPAPAPAPPVIETPTPATKKSSPEKKEKKSKSKDKDRRASAANVAAVEVASPVPEPPKSEKKARKKRKSAVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLB0</accession>
    <name>D4DLB0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000501">
        <property type="protein sequence ID" value="EFE37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018006.1">
        <property type="nucleotide sequence ID" value="XM_003017960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLB0"/>
    <dbReference type="GeneID" id="9579136"/>
    <dbReference type="KEGG" id="tve:TRV_07984"/>
    <dbReference type="HOGENOM" id="CLU_1566708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="19810" checksum="689A4ED420731F6B" modified="2010-05-18" version="1" fragment="single">QQQQQQQEEQQEEEEEEEEEGEKRRSRESQGGVFGERRREKRQQKRKKKGWSVSAGATKRYLGSHSSLGRKKGRKEEKKDDDVDDKDERARQRRQTDGDGGREGRRRTRLEDGVAVSGTCPPLSPPKQRTASKVQRAECRPGHPVRPAEDGHQDTKQTRNKRARGKRQPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLG8</accession>
    <name>D4DLG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF92 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_08042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000505">
        <property type="protein sequence ID" value="EFE37304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017949.1">
        <property type="nucleotide sequence ID" value="XM_003017903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLG8"/>
    <dbReference type="GeneID" id="9579827"/>
    <dbReference type="KEGG" id="tve:TRV_08042"/>
    <dbReference type="HOGENOM" id="CLU_036918_1_0_1"/>
    <dbReference type="OrthoDB" id="4171218at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="38521" checksum="D91D69F0E4E81EDE" modified="2010-05-18" version="1">MKPIIAVPATLLLVHRAWSRKSLTPLGIVFAAFTAVIHAIHPSSTPFALLIVFFLGGTRVTKVKHDVKARLTISATGAAGGEGSRTHIQVLANSGAASILILLDCYRIYYKNGDLSCLPYGRPESLLMVGIVSTYAAVAADTYSSELGILSKSAPRLITSPTFRKVPPGTNGGITLVGVAAGSLGAFTIAVTSMLLPFCSLGSPVAGCSKLGLDGGSAWGWNEQALWVLAITIWGTLGSLLDSLLGGLLQATVVDKQTGKVVEGCGGQKVLIHAGALTSKIMGDPPVRQETSLRTNEDIANALSPHASPHESHEGISDPAHESRKITAGSDILDNNAVNFLMASIMAVGGVAMASFIWGTPIDSIFREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZA2</accession>
    <name>D4CZA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000007">
        <property type="protein sequence ID" value="EFE45067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025678.1">
        <property type="nucleotide sequence ID" value="XM_003025632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZA2"/>
    <dbReference type="GeneID" id="9581917"/>
    <dbReference type="KEGG" id="tve:TRV_00143"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="44"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="33930" checksum="A2114FE648E7464E" modified="2010-05-18" version="1">MDEYETRARYNIAETCSSPISLDDLCAFAGDTRPADLFNASQKLGYGVIRGSEELRSNIAQIHVGSGDVAPASDNVLITPGAISANFLLLYTLVHAAAYSVPESLGAEVTLWKTSVEKDWELNVDELKDLIKQNTKLIILNNPQNPTGKTIPTEDLQQIINVARERNIYVFCDEVYRPLFHSLDTNQQPASAFSLGYDKAIVTGSAFKAYALAGIRVGWIIASKDIIEQCLHARDYTTISVSQLDDRVASFALGEKCVSKLLARNTTIARHNLNILTAFVEEFSSVCDWCEPLAGTTAFVRFSKKRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZF4</accession>
    <name>D4CZF4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000013">
        <property type="protein sequence ID" value="EFE45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025629.1">
        <property type="nucleotide sequence ID" value="XM_003025583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZF4"/>
    <dbReference type="GeneID" id="9581872"/>
    <dbReference type="KEGG" id="tve:TRV_00196"/>
    <dbReference type="HOGENOM" id="CLU_1817201_0_0_1"/>
    <dbReference type="OrthoDB" id="10582939at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055194" evidence="2">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="146" mass="17141" checksum="E00D1389BC6C8040" modified="2010-05-18" version="1">MSWIAAFAAVGTGVIAACAVSSEFRAWRAEMEKKKEKEKNKELEEREEKIVGWEQELASQWSDVYIERRELTGRERVLLQREIAVSQRNEASIRLSAESRRVCEEATRAMKTISEWEEALEERDTLLRLEQRRQTSIRRDVQQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZV7</accession>
    <name>D4CZV7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000019">
        <property type="protein sequence ID" value="EFE44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025481.1">
        <property type="nucleotide sequence ID" value="XM_003025435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZV7"/>
    <dbReference type="GeneID" id="9581717"/>
    <dbReference type="KEGG" id="tve:TRV_00350"/>
    <dbReference type="HOGENOM" id="CLU_106380_1_0_1"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987508" description="Hydrophobin" evidence="5">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="139" mass="14373" checksum="7FF2E1B00154A174" modified="2010-05-18" version="1">MKFSIAAAVLALASAVVAHPGAGYVSTPEKEANFQQNFQKFVTACGNGNQVSCCNTETKKVGAPLTAGGLIPILDNLNLEDFSLLKGCSKVDVAAVIGVQDLLNSNCKTQVSCCKVGDTNQVGLVNANVDLKCAAQNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D167</accession>
    <name>D4D167_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opsin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025010.1">
        <property type="nucleotide sequence ID" value="XM_003024964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D167"/>
    <dbReference type="GeneID" id="9580502"/>
    <dbReference type="KEGG" id="tve:TRV_00815"/>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="185" mass="21029" checksum="FA9CA122358769EB" modified="2010-05-18" version="1">MAMGYGVSYKHYTNHKHHKHSPDTIQETCREVYWIRYVNWMLTVPLILTCLSFLSGVNGASLLVSISAALVMFVAALSSSFMDKHYQWAWFVISCLGYLTIVYQTGFQGRRASLAKDQQARNFYTSIASFSLAVLLVYPIIWAISNNARKMSIDAEIIVFAILDILLQGVFGYWLIASYNTIRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D181</accession>
    <name>D4D181_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025024.1">
        <property type="nucleotide sequence ID" value="XM_003024978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D181"/>
    <dbReference type="GeneID" id="9580516"/>
    <dbReference type="KEGG" id="tve:TRV_00829"/>
    <dbReference type="HOGENOM" id="CLU_022339_1_0_1"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="565" mass="62684" checksum="80B17473679887BF" modified="2010-05-18" version="1">MLSSVDIQSGDVSPLLTTTASLNTSEPPLHAITLSVPSTDDLKTKLLPPASCPVADVDMDYSAAADNPDLSSTHFSDLPPEIHETILDHILGVRGSTLASITSATVTTSSWSKALRHPRRKALSDLALVSRAYRALVQGRIYRHIQVKGTTDCLAECAKWFDAHPHLKPYVRHIEIWVPVWGDRLRKSHFSPPSRRESGQANFGVIETNTMESYMHGLDALSSSRTNCNFKSASHNATLQQIFESVASQFPDAKMMTLEGGHCKKPPMIRHFESDPWGDSGLESLTPLPNIQTFIMKGAWNIMRDYSHWTNLSTALPNLREWHCFYAKSKREAHITISKVLRTFPPQLTRLNISLDGFCSKTSSRGFLNPQDEKHLCRLFGAILPQLESLTFTGKVCASLFLSGRAAVLSSQRKSKLKSVDLVVKACCWGHESDDGSLIPTDISGITNMSFIIEFEKLVIAAIHSLGALPALQYIRIRFIDLDSICGLLNPYFQLVGNTCTGVWSEAILKTLEENRPEAQFAELNNGILEDYGINSRTGTRSYPRSRPLSIKTSCYRIIADKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1B7</accession>
    <name>D4D1B7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024946.1">
        <property type="nucleotide sequence ID" value="XM_003024900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1B7"/>
    <dbReference type="GeneID" id="9580437"/>
    <dbReference type="KEGG" id="tve:TRV_00865"/>
    <dbReference type="HOGENOM" id="CLU_040566_4_0_1"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055159" evidence="1">
        <location>
            <begin position="32"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="308" mass="34991" checksum="4F0DA3396122FEDD" modified="2010-05-18" version="1">MPVRTARVDLSSLIRHAVLAFLVIYATTAEASCECGFVINDTQDYYTHLIHNNFSTYSPTKPLSTNPKFTRDWAIQKWGLPVMNWATPLPILNRPENVYLENGQLTLRQEGYSKESDDKNEIDIEILTREFKPDSMLVHYTTHPALDDRGWLIDNATEIIALKGHRPAEHFQLHRFDWTKEELRFYQNSKVVHTNNLRIPKDEGSVYLNLWADGGMWSGSPSTTDVYLRVKHLSIYHNTSASENGTDTAFSRRCQRAGGLSTETVCYDVHINSGLQVPSSKSKSLAPRPFWVLFLFSLALASAITSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1D9</accession>
    <name>D4D1D9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000052">
        <property type="protein sequence ID" value="EFE44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024968.1">
        <property type="nucleotide sequence ID" value="XM_003024922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1D9"/>
    <dbReference type="GeneID" id="9580460"/>
    <dbReference type="KEGG" id="tve:TRV_00889"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF280">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="53"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="453" mass="48869" checksum="CA502D42A488106F" modified="2010-05-18" version="1">MVDLEKDGKGQTSSLGIGGGSVVASSTTLPGENNDVDDAGYANNEHSYDSGWTAWSQVLASFFLFFNTWGVVTAFGVFQTYYEHNLLDHLSPSTISWIGSTQSFLLLFFGTITGSLFDAGYTRQLLMVGWALIPLGLMMTSIASQYWQIFLAQAICMGLGFGSVFVPCVAVLPQYFKKRRAIANGLAATGSGIGGLVYPIVFRQMQKSLGFPWATRVLGFIVFATMSISVSLLKMRFKPAERRSLVQLSAFRDPVYSLFCVSQFCGFLGLYNMMVYIQPYAIDEGIMGTDLAFYLLAILNSASTFGRIIPNYFVDFIGPFNVMIPMAFCSGIIALGWIGVHTTGSIIGIVILYGFFSGAFVSVPPVVLISITPDLRDFGTRLGMAFVFNSVGTLAGTPIGGAIIHASGNQYLGVQLLAGSCLLMSGILLVIASQKKTGINTLAGLVNLVWHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1N6</accession>
    <name>D4D1N6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucin family signaling protein Msb2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024853.1">
        <property type="nucleotide sequence ID" value="XM_003024807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1N6"/>
    <dbReference type="GeneID" id="9580344"/>
    <dbReference type="KEGG" id="tve:TRV_01018"/>
    <dbReference type="HOGENOM" id="CLU_313291_0_0_1"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055249" evidence="3">
        <location>
            <begin position="18"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="977" mass="97533" checksum="76891FEDE7A0B63A" modified="2010-05-18" version="1">MRLAAALLAAVAVEALGDLPAAHRPQHYFPRLVRRDLDRTSWGSSRKMVKAAEPMDRREVVVVPVTVKKGPDGSLHGEPSDLPHYYNAIIMPTAASTDSSTTTTTTSSDTTSDTTSGTSTGDSSSSGSATSSGGASSGAGESPSPTPTPTPTPTPTPNDPVTTPPPTVYPTAPTVPSMPSEPSEPAEPSEPSEPTLIIPTAPSSKPTVPEEPTPSAPPTPPDEPVSSVPLPPVLSSPPVTSPSSPEMSTPAPTLLPTSFPTLLPPEEPPSSSASSQPPQDPSSYTPPPQVPPSSEAPISPPADPTTTPGAPESPVPTSVVPSMPSVPSMPSMPSMPSMPPMSPSQGVSHPGGVPTGDSTLIPLPTLFPSSSAPASPPTQPGQSSQPSQPGQSSQPMQPTPPETPTIPTTSATGGMTYPGGGTGTGSNPTSTEGTGILPTLLPIPSDSTGTSTGTSMGTSTGAGTSAGSSTGTGTTSTGTPISSPSSPVSISIPISLPTDLTSVTNFPTYSPSGDPATVTGPGSGTATTPITSILPTGTGTSTGTTGTGTSTGSSTGSSTGTSATTGTSTETPTSVTFPSLSIPTGTASTSSGTIGTGITTTPTGTGTGTMGSSTYSSHPTSASETSTSGSGSDTSTVHPSTMMTVTTTTRPSSHTPTPTSTMPSSSAPISTNSDTTLSVPTSIIIQPSTTTTTTSATATHSPKPLPYMISPPNAKPPPPDSVLIQLGFNGSLPYEFIALNTDVVTQIFTFMPLGVSYAVEVDKDETPITGIGQYDRGTHKGYTTALVFCFIPKDVYKVLATSLTTPQSRLYTNPDASTFTLMSMIDPTIPLLAGGQTVPGGGSAPYPGGLPGSGNNGGNGDGTDGTENKGKGPGGSAGGTGIKPTAVGIGLGVVGGAALYGAAMFFVARRYRKKRNLHRRSDSLTSGMGSPTPYHDEQRAGSPFAGTTMNDRYSGAGSGRTAQISAPVMAENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D221</accession>
    <name>D4D221_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024716.1">
        <property type="nucleotide sequence ID" value="XM_003024670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D221"/>
    <dbReference type="GeneID" id="9580206"/>
    <dbReference type="KEGG" id="tve:TRV_01123"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="460" mass="51475" checksum="9EFB8F53222CAE8B" modified="2010-05-18" version="1">MNLLASLKTNIGWPAVIGVAVAYYGTLVFYRLFLHPLSRFPGPKLAAISRWYEAYYDVVLGGQYTVKIAELHKKYGSPHELHVIDPPFFEKLYRSDGRWDKYSWTYDAFGAKMSTIFGSDHYAHKARRRALAPFFSKANIIARQDLLQKNIKKLSQRITSFEGTTFNLGAAISAFARDNANELIVGKDYNELSLEDFGLGLSLASQGAGVFWHTRDTLAAAISPSPDDKIKSTLIYSIAHSDLPPAEKTFDRIFEEVATVTGAGFETISNTLRLILYHVYSSNEILQRLREEINAASTTVTAPLTLKELEQLPYLTAVLMEGLRLSPGVGSRAARITDQDLFYEHWRIPAGTPVGMATILMHTDENLYPDPMCFNPDRWIDNTAKRSTTTFAPFSRGTRICLGMHLAWAEMYLLLASLVQGFDFKIKDATASDFAFEKDNFGIGTKAACNLIAYVMIHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D269</accession>
    <name>D4D269_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_01171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024654.1">
        <property type="nucleotide sequence ID" value="XM_003024608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D269"/>
    <dbReference type="GeneID" id="9582829"/>
    <dbReference type="KEGG" id="tve:TRV_01171"/>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="781"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1174" mass="129710" checksum="EB3377E0E09DAE52" modified="2010-05-18" version="1">MSLIGDHVRRLDAYVDRLQLRGLAEAGVETSQQREAAAAGTREATTTTTTTTTTTTTQDVRRAARRTGRAQEDLGSVRPPLLAAARALSGGHTLKPARVLDHLRRVHRLQQAIQTAETRYTEYEDKDAEEGDYDAPAREYTTGLLWLVASKATVQTFAAVTSSMVDETVPLSDGIWYWDEVLGSAFYSGLYTLQTAPARWASYLISIYRNIRQMGSNDNGNNARHARRGSSAEDLSVGSGLHDGTTLMARWRAFYRLVHHSVRARPVSSSQARELVLSPFQLARCRARASRSGLRRLREMTACAVGLLMEEGLLFDVADEDEAITPPAIITPDTGPGGSAAPDPAPSSSKKHDSPDEWRDLVSRTTVLMQTVLQHVNNLDTDLTGFEDNVFSTVGSGIRAMEESLVTIDETAGTGRSPSPTDQAYLVIQLLIDVLEHHLPHQQEQSRLLACNYARPSRLVRYWPAALALLLSSSTVLNILTSRQAELLTWLRELGSTVSDFWTNWIIEPLTRLVGTIRHDEKSEVALMSKNSLDADFSSLERMVVDFVRTRPSQDLGLSGHPDALDLIRQGVRQGDLTPVLRAYERDLQRPFIGAIRGDLVTALLIQIQKTKVDVEVAISGINSILKSQELVFAFIGLTPSILVSYATVQWAAGLLGSRRGLRQGQRRSEIVRSLRTVNRILMSSLPSQTGVLSYKDHGLLICEAETLRRRAERVLPGAIYHEFHEDLNDLLNVRAGIAHQMKVVDQIRWTYSKWIYSFSALSPASVQKVETLTSSFDRQQQLASHADITQPTDRDAGNEQTETGRGRPGLPVGLRCPLLTHAVSQLSRHRNAPEISHPPAQHPDGQTDRQTDRGEQGNSDSQKRQINSPRSLSVSPLFLPDSIHPGLGSRLDGPIASRKHSSVTRRAAASTPANTAASDTASLASQLFFYRRGLPRCPQTSYRPCESSTDRPAPSHSLTRHRSRESTWFLVLTFTLQIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTINLDGKRVKLQIWDTAGQERFRTITTAYYRNAMGILLVYDVTDERSFKNIRTWFSNVEQHASEGVHKILIGNKCDGEEKRAVTVEQGQQLANELGIPFLEVSAKNNINVDKAFYSLATEIKKDMDVSKAEQAGSQGVNIDNQNGGAGGSLGKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D270</accession>
    <name>D4D270_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024655.1">
        <property type="nucleotide sequence ID" value="XM_003024609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D270"/>
    <dbReference type="GeneID" id="9582830"/>
    <dbReference type="KEGG" id="tve:TRV_01172"/>
    <dbReference type="HOGENOM" id="CLU_1612009_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="165" mass="18234" checksum="296C1B16930FE9F9" modified="2010-05-18" version="1">MAEKNEFGAIPLFLQGRDFILQQTVDDHPGKRAAKVDDLVHGKGHDAGGEDVVLHVGVPGRPHLLEDIELGVYVSGGGESSVVEFLQVPKVNKRPARRRTERATYMTDRAQREPEEKPAASGEDSGVSRGMNRQRRLSRWSSLSVSSLLLLLVVEVEVEVEAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D274</accession>
    <name>D4D274_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024659.1">
        <property type="nucleotide sequence ID" value="XM_003024613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D274"/>
    <dbReference type="GeneID" id="9582834"/>
    <dbReference type="KEGG" id="tve:TRV_01176"/>
    <dbReference type="HOGENOM" id="CLU_036204_0_0_1"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="309" mass="34698" checksum="748256E6D96D8871" modified="2010-05-18" version="1">MTVETLPAWGIYIELLGRMDVNENVDDLFDYDAGLDDILRQVEQDTNKTTAASSSQDQPNPGKGVLGIDDELQVSRKRAPVAQLDEARLLTVLVQFSDAGRLLNFYRLWLDELYPRAKFTDTLATIEKLGHSKRLQVMRREWIDEGKPRPEVDDDDFQLGKEQDLPTREKGNQQDGARLNPEEEDLFIDSPHPETTFSTQDAVKSLFGGDGNEQSSVLNTTSIDNELFEWESNDKALGDPPKDNIDHSGTNKVPAGFPDDEDDLDRPLAEDDNGINSNSIRKPNAEASASNAVADEYENDWEAMQEHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L3</accession>
    <name>D4D2L3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024488.1">
        <property type="nucleotide sequence ID" value="XM_003024442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L3"/>
    <dbReference type="GeneID" id="9579705"/>
    <dbReference type="KEGG" id="tve:TRV_01318"/>
    <dbReference type="HOGENOM" id="CLU_053359_0_1_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="86"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="346" mass="38342" checksum="9EC58AFB360342BC" modified="2010-05-18" version="1">MDNSVDGQGAPGAGGATPGASDNTHNNNANGNNIANGGTIPRQRGASYSSQRSRKGSIHQDQPSWYRRILEKYGSLELENKGSVARDHLALERTFLSWLRTSLAFASIGIAVTQLFRLNTAIQQLDPSQNSPSNPSALLSEHYRETSKGLYFTITSNSSQLRGLGKPLGATFIGVAILVLFIGFHRYFESQYWVVRGKFPASRGSIALTAFITASLMVSSLVIILTISPVTCIYAEFIEFIFLSSSCWITGNNNEGPRHITSCYPSTYLDPRKAKTKIASFAYLVIRFGLLLLIFLLLLPCIVHLLLVLAFPSVMLFFEYPAYRRLWFTLFVSFFSPSVDLFIFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D345</accession>
    <name>D4D345_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_01502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024304.1">
        <property type="nucleotide sequence ID" value="XM_003024258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D345"/>
    <dbReference type="GeneID" id="9579478"/>
    <dbReference type="KEGG" id="tve:TRV_01502"/>
    <dbReference type="HOGENOM" id="CLU_103863_0_0_1"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="174" mass="20060" checksum="73FC57E854668993" modified="2010-05-18" version="1">MSTQVTAPGAEEWYRVYKPELDTAAFDPLDPEKRYHEGVLVETNPGYGKGTLFHVTGDIIAASGMRYEEREFDREMESEYLHSFPQTGRVLRTDFHSGKISAILKELPRPTKQQGINFWEVDPTTGRHEIIWTRQDGERYGPDEQRRPIFKCNEWTRQYAIPALRGAGVLLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3H2</accession>
    <name>D4D3H2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000084">
        <property type="protein sequence ID" value="EFE43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024199.1">
        <property type="nucleotide sequence ID" value="XM_003024153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3H2"/>
    <dbReference type="GeneID" id="9579237"/>
    <dbReference type="KEGG" id="tve:TRV_01632"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="100"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="645" mass="69374" checksum="384AABF60A63DD53" modified="2010-05-18" version="1">MAGLMESTATVTGGQDEAATEIKSSSSSLEGSTDCSAKMEAPKMLAGGAKEAVETSGPAEADEKQEEVLQDRYQEKEDSRDDHGPEAQEAPGAPAGSSEVKMSKGKVALIMLALCTIVTTALPTIAREFNTSQADYAWVGSAYLLGAACMLLLPSWAVVLVLTCFLASTPSWGKVSDIFGRKPVLLAANVVFLIGSLLCGVSINIKMLVASRVIQGIGSGGLLTLVNICVSDLFSMRTRSMYFGIIGMVWAISGIIGPVIGGLMTQYTTWRWCFYINLPIDGVAFLIIFFFLELHTPTTPLLAGLRAIDWLGSLAVVGGTVMFLIGLEYGGESYPWSSPTVICLIVFGIVTWGIFILIQWKVSRYPVMPLWLFTQRSTLAAYGTVLIHGAIYTSGSFFLPLYFQAVLGETPLKSGILLFPNVIAVSIVSAVTGIFIRKTGLCLPPIWFGTTVLVLGTGLYINLPSHRSLVKVILYQLVAGMGIGPNFQAPIIALQSHIRPSDIATATASIAFCRNLASSISVVIGGVIIQNRLQSNILEIQHLLSPKTLDALQGVSAGASVHIIQALPPNEKQPVLDAYTKSLSTMWIFYTALAAIGFIVSLLLQKKRLNKEHEVTKTGLDAQERARKERLQMEKEAKSSRNKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3R5</accession>
    <name>D4D3R5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000088">
        <property type="protein sequence ID" value="EFE43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024127.1">
        <property type="nucleotide sequence ID" value="XM_003024081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3R5"/>
    <dbReference type="GeneID" id="9577124"/>
    <dbReference type="KEGG" id="tve:TRV_01727"/>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="825" mass="92865" checksum="E6AE1486BE9FE779" modified="2010-05-18" version="1">MASKEGPPEVPKLAPDLEIVGDQVRIQPTGFTAGIEETDGITERRLMHQMGRFRENPFDFLREISLFVSGTGWRAYDDFIGQPIFYSGFSEKMKSSVASHSLLVGKIEELAESRVKTEEVEGLLSVTAPASSNGEPSVDARTRRKEEIAASLREVVDTMMDNMICKMESKSFIRGAYYITTQILTRAYHQGIHVSSEEVLRLRKVAEEAAKKKQSIVFLPCHKSHVDYASLQVICYRLGIALPVVVAGDNLNIPLLGSFLQHAGAMWIRRKFGNDPLYHALVQAYIDTLLSNGHNFECFVEGGRSRTGKLLPPKYGILRYVLDSVGSGRVEDALICPVSTQYDKVIETESYISELLGQPKQKENLRDFISASSVLSLKLGRIDVRFHEPWSLKQFITQQTTKIHHMPTNERNLMATISQEERSRILRTFGYRVLSQINDASVIMPTALVGTVLLTLRGRGVGKAELSRRVDWLCHRVKEKGGRVAHFYRAPTAHVVERALEVLGPKLVGKTAGLAEETYHVVDRFQLSFYRNMTIHLFIPEALVSVALYSRVKKGGEPSNQQITYDELLTRVSFLSQLFRGEFIFPPEGLTANLEKTLHGLERGNVLKVTKDASNVPQMIELSEHERNCGRENYDFYCFLLWPFIEACWLGTVSLIGLTPPLTDPTNVWVDMNKAQSNAQLLGKTLYYQGDLSYIEAVNKEILKNSYQRFEEEGIIITAKSKESPQPPTMRVSPEWAPERDPETGKLLPQGKLWEFIRMIAQSRREGKNRRDGETISTRVLELSEAMGRTLFQAAHPVKPASAGGDVELSSQIQRRRAIDTASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D436</accession>
    <name>D4D436_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023988.1">
        <property type="nucleotide sequence ID" value="XM_003023942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D436"/>
    <dbReference type="GeneID" id="9582681"/>
    <dbReference type="KEGG" id="tve:TRV_01850"/>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="475" mass="54222" checksum="E13598384F33C113" modified="2010-05-18" version="1">MATEVACRRCVQALGLGIRRNGVTSGPKLKQLARLSHSYRTYSTPSRKNISPQQQGQLRLNGCRSQTRGTASLALSQEASASEQSEPKQPLLRRDNLFHSYSNSPSPQIRKRAQFIKQHAFCPHPDHQQTRASVSPVCSEAEKPGIPNEQKQPPAHAQHECPDCGVPIYCSEEHWMDDFEAHLQVCETIRQINEDDHDLQSGRFFTEFDYPGYQADEIVVNMTNWDTFLYTREFEAVNDDRSMRQVTRLLTYPVTIASVLHELSPYNISKGGRLTPEGLKSLSESSLPREVWMQISHLFPRATINLIFTGPESMANRDDEFPLPERTASNPFGGIVEDRLGPQMKITTYVDYFHTMHKANMFAPYDPYFDCFMLFHPGLGHPASSHEWEETLPCLLETKVPIICTGYTQSDMERDLNWVKEKCGGEADILLEQGENRFRSLRWDLNDLDPHDVSCGNWGVWAFRGKRYEATFKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D442</accession>
    <name>D4D442_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023994.1">
        <property type="nucleotide sequence ID" value="XM_003023948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D442"/>
    <dbReference type="GeneID" id="9582687"/>
    <dbReference type="KEGG" id="tve:TRV_01856"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="129" mass="13817" checksum="26409E797B7A8243" modified="2010-05-18" version="1">MEPVFTKDACPRKSSLAPPLPRRSQAIKAGGQVFVSGQIPADNTGKLLEGSIAEKTDLCCRNICAVLTAAGSSIDKVVKVNVFLVDMADFAEMNGVFEKYFSHKPARSCVAVHQLPKGVPVELECIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D475</accession>
    <name>D4D475_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023948.1">
        <property type="nucleotide sequence ID" value="XM_003023902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D475"/>
    <dbReference type="GeneID" id="9582641"/>
    <dbReference type="KEGG" id="tve:TRV_01889"/>
    <dbReference type="HOGENOM" id="CLU_1360511_0_0_1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="2">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23285" checksum="DBAF241FA4AAE30B" modified="2010-05-18" version="1">MGTNSPNPVPFSEPPYLCGLPSPYYTEAHRQFQKACRAFIWEHLHSRAMEWEREGTVPPHVFEAFAKHNMLLPNLPSPLPVAWLKKLNIHDILGVKVEDWDLIYTGIYLDEMSRCGLSGPPSSLTAGFAFGIPPMLAFGSREFQEKFLPDMLTAKVRSCIAITEPDAGSDVANITTTAEKSADGKYYIINGEKKWYILVPGVQFTTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4D2</accession>
    <name>D4D4D2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase activator (Lrg11)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023897.1">
        <property type="nucleotide sequence ID" value="XM_003023851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9582497"/>
    <dbReference type="KEGG" id="tve:TRV_01947"/>
    <dbReference type="HOGENOM" id="CLU_001321_1_0_1"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="262"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="811"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1350" mass="149646" checksum="77A3DF707D85D2FB" modified="2010-05-18" version="1">MLLMKPAPSKTPLPARGWKAALVSDCCVNLPRHPALFQLALTYTLAHFSPRSTSAAAVLFFLSPVYRPDRLAIRAALSRISLSHSLACFLSLNRRALNLQNRGYRSPFLSFILPLTDPPCLSSEAKKIKKRETVSTKRNKKKKAGYSPRAEVVDADMASAGGRHIPPNLLPGNRGEDGGLQITNTSGFQGQSPIDSPDGNRSAPWSDIPPSAPTESNVNPEERSPRQPDSYRSPGRTKSRDRHNNNNSNGPSTSKSPSGNTRICRVCGEPLLGQFVRALGGTFHLECFQCKDCGEIVASKFFPVDSEDGNSQHPLCERDYFRRLNLLCFECGGALRGSYITALDHKYHIEHFTCSVCPTVFGAQDSYYEHEGKVYCHYHYSTQFAQRCNGCQTAILKQFVEIFRNGQNQHWHPECYMIHKFWNVRLSPSGKTFEPPEIDRDVSNEERDQIRDEEEKMEEKVYRIWSVLSAFEESSAACISDMLLHVSNGAYIDGVVVAKKFIFHVEVLFKGTDQLASQISALGVKEMAYGREAKLLCKKVVSFFSLLSKTQETGVRKLGVTQELLALVTGLAHYLKLLIRIGLQGSLRLERETKTPDALYAFLDLTADLEEVNTITASDLNTDTSQLAHSQSDCCAACTEPIDDECIVLGRRQWHKKPPHLVCGACQDDLTHDLERARWSEKNDRPFCQNCAVQRGHDPQAISGFENVTKLQQYVFLLRVALARLLSVLRSGGTLPHTSDDPNLKEYEANDGHRIPPQADPHVPPQRPTTRSMSYTGEQNEEKAPSSLEQTVGEMRRLRSTRNERAISTTFKKARTSRIISGPESSSVQPGAPGSANNGQNQNFQIVEERDADGEPVADLTFGNQDALTLDDIPRIVAAEQAKEQRPNAYKHAGGNLIGSGGPAAKLVNGHQRGVSVDQLGAMERPRAKKYFSELSALEYFIVRHVAVLSMEPLLEGSFNLEELLGLIEPRKPTIWNIFNRAFKNDPRKVGKKKGVFGVALEVIVERDGTESTHGVGPGTLRIPTFIDDAISAMRQMDMSVEGVFRKNGNIKRLRETAELIDTKYEAAELDKESAVQVAALMKKFLREMPDPLLTFKLHSLFVIAQKIADPVKRKRVLHLTCCLLPKSHRDTMEVLFSFLNWASSFCHVDDETGSKMDIHNLATVMTPNILYSNAKVAGVDDSFLAIEAVTSLIENNDTMCEVPEDLLSILTDSTLFNGSAEITTKEILKRYGALGKLPVPQRAPTIAETIPVRSGSSKGNNSPIAARIDTDPSQATAWQMQSSVRHVHGPQDHNAPFPPQPIRTNTGDSNQGHGQGQGQAYSGVPPQKPQHQQHLTQPPMAYRGRPPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4L4</accession>
    <name>D4D4L4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023834.1">
        <property type="nucleotide sequence ID" value="XM_003023788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4L4"/>
    <dbReference type="GeneID" id="9582409"/>
    <dbReference type="KEGG" id="tve:TRV_02031"/>
    <dbReference type="HOGENOM" id="CLU_035996_1_1_1"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="360" mass="39495" checksum="2C76640E374A5B2C" modified="2010-05-18" version="1">MFKRRLIAALEDNKPPRRMREAMAQAQAQAQRMASQTGSSSVSPTTIPAAPAASGTAIATPPAPSPPPATPAPPSNVVDPPSDTRSNDQQRRDSIREGKRPAEPENEKKEQAEWKGKQKRRHQQEREERERVLERIRRDNEERKAKAERQRAAAAEKHEATRTPPPTAQTYRLQVRLFDGSSIRNTFSPNQTIGTAVRSWLDRERSDGDAPYTLKHILTPLENKTISLSEEDQSLQELGVGPTATLVMVPIRTYTDAYSDSGASLPYRVLSGGYSLVAGTVNAVAGIVGSALGIGQNPAAVGRGASTQTEATEETSTTSPRTSTRNRVRTLHDANSGKNDHQFYNGNQLNFEPRKKDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4R2</accession>
    <name>D4D4R2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000109">
        <property type="protein sequence ID" value="EFE43158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023776.1">
        <property type="nucleotide sequence ID" value="XM_003023730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4R2"/>
    <dbReference type="GeneID" id="9582354"/>
    <dbReference type="KEGG" id="tve:TRV_02078"/>
    <dbReference type="HOGENOM" id="CLU_019373_0_0_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="88929" checksum="03DDA8C0FDA9988A" modified="2010-05-18" version="1">MSFLEQYTSSPSPSILSPSQPSSRPSTSQWYHDQILRELPFISGASRSRSGSPSRSRNNTGTQTPKRLSVLGQRSRSDTANSSNLSPASSMTSSKRSSHDGSKGVFDFVLPLEKEESSSKSFFSRGNRILRRQGSKFSLLDTLTLDEEEEMSSDQVWYGEKVKPRREKPAVLRRINRQRNPTSHSKLKSSISEPFHFQHITHTSRGQLPPIAHTHPHDLATEFSIIRASQRPNSELKGIHAQNLSCRPYTAEEESDWTLDTLAPDAPSLFTRSPPGSPRATRTTVTSPELRQLRAPRSVENFSRPVSRIVRQPFSPPMIPPPRRSSRMAMSPKSGGQRTDPSEELMGLNGLSLSPVEDGPINAVVGYAVSPPEQGPVAEPIEEIGRAFSPDENNAPSTNISPLVQPSGVNERDEPQSNHVIAFDPAPYNAHMEPELVEIPSELKKPALHLSPLKETRFEYEDLHSPILPSEQPRKLLPPVEPKSPAGTVGMHVSNDSWEADIDYCYEHAAESNSNFDWNRESAEESRDRECSHLGKSETSGCFKSNTSSFYLHPLDTTTSGQTTPELQPSSGISASTRAESDAASPAIFNHSFGTFPSAAESMDKKPKTTEIQVLETHFEDVSHDSVYTHVISDINEDDEYHIDEPAYTRTGSSPLSKCNSQESMMLSRAASIVRKHRSSTSTNSVPDLIHSPNCSREMVDREAPTSPLAERPALPTYSRPLPIGREGMPRMPFASFSGIESTSNPSVSMHDRSKSASVLDSADCSLSRTSQVNRKRASTLSRGVRKNRPSYSLFPVTGPATSPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5I8</accession>
    <name>D4D5I8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_02359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023508.1">
        <property type="nucleotide sequence ID" value="XM_003023462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5I8"/>
    <dbReference type="GeneID" id="9583528"/>
    <dbReference type="KEGG" id="tve:TRV_02359"/>
    <dbReference type="HOGENOM" id="CLU_1908214_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="133" mass="15536" checksum="2BFB286EE3EB14E0" modified="2010-05-18" version="1">MHDAEIEDSDSGVEVNYMSMKLIDGQTPKACWDTLIIDEKKGTRTNYFIELRSSPSPKYHSFLEHLQCKNIIVKKKGVHNPSRKDWKYEVTPIDWEEAGWYPGYQEYTLAAHASGWEADWPNRLPKLMDPYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6A1</accession>
    <name>D4D6A1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000135">
        <property type="protein sequence ID" value="EFE42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023235.1">
        <property type="nucleotide sequence ID" value="XM_003023189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6A1"/>
    <dbReference type="GeneID" id="9583259"/>
    <dbReference type="KEGG" id="tve:TRV_02624"/>
    <dbReference type="HOGENOM" id="CLU_291738_0_0_1"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000052">
        <property type="entry name" value="F-box protein (Pof7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118147" checksum="F0154E28419108D6" modified="2010-05-18" version="1">MAGGQQEDELESFRRQWLEEVRTRHPPPPAQSQQQPASEARPAERRKSLQPRPQASIQLPQDLADEADEDGYTKIDTSELDGEFKSLELGSQKTEEKAPQSALEHFERAIEKEDQGRLGDSLSLYRKAYRLDAKVDQAYREKHHANAKPYMPPAAPASGSTQPSAGEKVDIASFASLPILPADPIIENTPPPPCPIARLPSEVLIEILKHVALLDPALFFRLSLVCKRLAYHFMHEQHIWRRLCQGTEFGLASMHYSFACQINGSPIDKGYVLGSDSDSESDSQIVHSHPFTAQITATIPKPLTSWSHVFQAFPRLRFTGIYLSTVNYMRPGANSAMQSVSWNSPIHIVTYYRYLRFYPDGTVLSLLSTTEPVEVVHHLSRENIDLLAASSAGRKHTRHISDTPAPAPQAISTASPMPPTAAAALKHTLRGRWRLAPPTLSHTGPAPTNPDSTSGQPSNRQHTSAEPPSASTSDPRDLFIETEGVDPKYTYSMHLSFRSAGSHKSKNTKLAWKGFWSYNRLTDDWAEFTLRNDRAFVFRRVRGWGLPIVHHLFDVMVGDTVPNPEVPVENGVVDKPSADPPAIEEPLAQEPPAPEPTIVQDTTELTARKLNTQVEETKIEVSPKAEPTTNKLASESTSTESTATEQTSNELVTAKSSTPDTTATESTSKDFTSEASKPKEPFTLPLLRGKITLEDALVQEEDMLIRLSLVDKRFDFFLWIVQHKKEIQELVSFQLGLSSPEQCRVGEVREWLHGSFNVCVPIYVNKGVTPTEKRLLIRFPLPYKIGETNYPGNADEKLRCEVATYVWMQENCPDVPIPKLWGFGFVDGQTPNSMNDEEDGRSQMANLAMMRTVLSDYTSRDVRHGPFFFQLTDLHQSNIFVDEDWHIRYMIDLEWACSLPVEHLFPPWWMSGRFVDGLTDEHLEVFTNTYKEFADIFEEEERLLAPSPINGIELYRTSIMRRGLSKGTFWYLSSLDSPKGLYNLFHQHIQPRYAQDHRKGSEYPKITYKYWAADADEVLSTKMKDKEVYDEKLRELFRKSANEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6H0</accession>
    <name>D4D6H0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023173.1">
        <property type="nucleotide sequence ID" value="XM_003023127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6H0"/>
    <dbReference type="GeneID" id="9583193"/>
    <dbReference type="KEGG" id="tve:TRV_02695"/>
    <dbReference type="HOGENOM" id="CLU_054794_1_0_1"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="283" mass="31211" checksum="5C14E9C3136E4AC3" modified="2010-05-18" version="1">MVKFYPSIEPDHREWMLNQPVFFVASAPSFGKHINISPKGLPSTSLAILSPNQAAYVDATGSGNETLSHVRENGRITVMFCSFESSPRILRLFCTGKVIEFDDPAFKGWVGKMGVSDRYIPSARAVIALDIFQVRSTVYVYVLFYIYSTISESLRPNVLQVQTSCGYGVPLLALRTDADTGAVKPYLQDRDTLVDWAEKQAEKKQLSKYMNAWNAESLDGLPGLRAAMIARGQSDAAVSLSIALCKYRRPLEIVSAVLMAVLALWLAGCLKQPAFFGRTGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6M4</accession>
    <name>D4D6M4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_02751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000144">
        <property type="protein sequence ID" value="EFE42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023108.1">
        <property type="nucleotide sequence ID" value="XM_003023062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6M4"/>
    <dbReference type="GeneID" id="9583137"/>
    <dbReference type="KEGG" id="tve:TRV_02751"/>
    <dbReference type="HOGENOM" id="CLU_010595_2_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="269" mass="31279" checksum="C2146F6E58B3D69B" modified="2010-05-18" version="1">MHRFWDLSRTFFIYLSLITQTRFHFRLDDRIRSDLCFVLRLANTIGIWAIDIAKKYPHAYVLGIDLAPMQPTNRPPNCEFQSPRDFESPWLLGENSWDFIHLQMGCGSVSNWPNLYSKVFAHLKPGTGYFEQVEIDFEPFTVNGMPNEHLSEWYRQLKAATDKAMRPIAFNRSMKHTLKEAGFVDVRQHVEGLPLNEWPEDPSDKLVGKWYNLAFSESALTLLQGPLTRISGMSLDRIQDLADQAITQAYDKNVQAWNHLQVYTARKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6M9</accession>
    <name>D4D6M9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000144">
        <property type="protein sequence ID" value="EFE42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023113.1">
        <property type="nucleotide sequence ID" value="XM_003023067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6M9"/>
    <dbReference type="GeneID" id="9583133"/>
    <dbReference type="KEGG" id="tve:TRV_02756"/>
    <dbReference type="HOGENOM" id="CLU_002546_3_0_1"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="490"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="801" mass="88786" checksum="3D5A11D1B3A2AAE3" modified="2010-05-18" version="1">MFCAARRPQHLRLRRQPQLQLPTTAGVVPVFVEYPVSLSLSSLSLSLFLRALPVLSSYVRSISGSVSKTWNSINPATLSGAIDVIVIEQEDGQSLPGPGDTLMHAVADRPDFRNTRMLAVPCPFRQILPPSAVREEVILQVEFSVNGVKQDYAMKLGEGGEAFFVFETTGDVPEDLQTSPVISPAASPQQSPNEPSNNSTLNLQEPEYLDLTSKSSTPPKQTRATTEPLLDSETERSSPVSKNVREPGHKLDRSRSDDLLEAGRANGQSANSSPQTTRSQSPPPISRQEAYSRAISLSKKLSGSNIPSKVTESGDLMLDMTGYKSSEDEALRAEVVARKILAEELEGNYDIGALIGADEHGNLWIYSSEEAKEAAGRKASYSALQHHNGMADDAVSDPGYQSDNDQLDYNNHPQKHHRSQSDAQLEYPTPPQTPTDKQPEGGRSYAKTLRLTSDQLKALNLKPGANPISFSVNKAVCPATMYLWSYKVPIVISDIDGTITKSDALGHVLNMIGRDWTHLGVAKLYTDIASNGYNIMYLTSRSTGQADTTRAYLKGILQDGYKIPQGPVIMSPDRTIAALRREIYLRKPEVFKMACLRDILSLFEGRQNPFYAGFGNRLTDALSYRSVNIPSTRIFTINSNAEVSLDLLSLTKYKSSYVTMRELVDHFFPPVSTLVQEGGEEFTDFTYWRDQPRELDEFSLTDTDAGSDRADDDDEYDLDHRSGIHETYISRDSIEISGDMNDSIHDSVYEDMDDISEEDEYEEEDDRRMSDEVPAWSNEEDTDDPGVPKSPARTPRSLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6U1</accession>
    <name>D4D6U1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022997.1">
        <property type="nucleotide sequence ID" value="XM_003022951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6U1"/>
    <dbReference type="GeneID" id="9583017"/>
    <dbReference type="KEGG" id="tve:TRV_02818"/>
    <dbReference type="HOGENOM" id="CLU_056567_0_0_1"/>
    <dbReference type="OrthoDB" id="4173901at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45567" checksum="93ABD0BE50FABA15" modified="2010-05-18" version="1">MPANNAKRRRSDDVDFSSNHPTASATPSLPAIGEKRDADPSGVSWWLAGAAPPIRYLFNADGSTAARDSPTPYRRPTKPYLLRLQWFKSQGHSKTCPDCRAPVKATPAPAYLVRNIVHMFIGRSELTDANETTQEHLANQVAETEKVERDKQNTDPRTGGLFQGCFNNTPIPLYDNAEGVSRCPGCFWELEDGECTHCGYTVSDSDQDQDLDEFEVMEQLRLMGDAFTEDEDGSDFIGHRHNPGFEYNFLPYDSGHITDITDMDADSEDVYTDDNDDITDAGDAESNLSEDESLRSESDSSGRSNSTARRASSDHGSQTIEPESTPSVQEISSSAQSEAESEEEPIRRPVRRRVSRPRQSPQHISTDQATRMTLPMILLASMRGTDPENAVVIDDSPPPRRTSRRRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D716</accession>
    <name>D4D716_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000148">
        <property type="protein sequence ID" value="EFE42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022989.1">
        <property type="nucleotide sequence ID" value="XM_003022943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D716"/>
    <dbReference type="GeneID" id="9583009"/>
    <dbReference type="KEGG" id="tve:TRV_02895"/>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="361"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71649" checksum="C620BF5E18C77A0A" modified="2010-05-18" version="1">MVAEEYGVVGCRFWSTGFVALLSNNQLVAVSHYDEPRPKLLAQSPEGEINSWSLIPPTYTLSRSVEVLLAIDKSIYVVDAADCEDRMLQNGPFKHVSVSPNGLFVALFTGDGKLWVVSSDFQNKFSEYDSHARTPPGSVTWCGNDAVVLAWEDEVHVVGPNDIDGIRILTNDVCEFLHKVPDATEEVFRLGSSAPASVLLDSVEQLEKKSSAADENIQRIRANLVEAVDTCVRAAGYEFNTYWQKQLLKAASFGKSILELYNSDEFVDMCEKLRVLNAVRDYKIGLPISYEQYMRLTPEKLIERLINRREYLLAIRVSEYLHLPADKIFVHWAIQKVRSSTEDDDSICQIVVQRLQGKQGISFESIARSAHEEGRSHLATQLLNHEPRAGKQVPLLLSMEEDTLALDKATESGDTDLILFVLLQLKRKLPLATFFRTLNNRPIASALVEASARHQDEELLKDLYYQDDRVIDGSNIHLKDALKQTDLHNKTDKLRVAARLLSDSKDTAVQAQLKSLNDAAYLLKIQDGLDKELADNNDLFTGLSVNETIYRLIRSGYGKRAIKIQNDFKVPEKTYWWLRLRGLVAKRDWGELEDLGRTRKSPIGWEISPLFVLIAAPLSNFLRLEANFITLVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D742</accession>
    <name>D4D742_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000150">
        <property type="protein sequence ID" value="EFE42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022934.1">
        <property type="nucleotide sequence ID" value="XM_003022888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D742"/>
    <dbReference type="GeneID" id="9576960"/>
    <dbReference type="KEGG" id="tve:TRV_02921"/>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="63925" checksum="AB9CB5A2985D22F4" modified="2010-05-18" version="1">MKLINLVDVNLVEGLLQNSALLTRDYYQDDTKAAPKTAKEISLLSVPEACPHFMSSHEEVFQYNNGHFLVDEEYQYARRYVRFNINELCNLVTSVVTKSDSTVSKVTKIEKMEGGFHKALLMTLENGAEVVAKISCPNAGLPMLSTASEAAVLEFVPKVLAWSSDSKNLVGAEYIILEKAKGVQLTKVWGGLSESRRLDIIKNLVLIEQQLLSLQFPAYGNLYFRRSIPNLPHVPLDKEFDPSSQYCIGPAASLQWADGGRTPQCGSGPWMNLQEFGESLAKRSLCKGFPTVRAAGGQPPSYGTPSSHKSVLESAINILPKVSSHQNLVKTSTPVLLHPDLHMGNIFTTEEGKDTISITGIIDWHSISIAPKFLQARWPVFLEPLDGYTPGLTEKPEPLSRLEGMDAADRAVAKVTYEQNYLAKAYEVCTGAFNTHLHTALLVPSALKEIYIRCGETSVDGIFPLRSCLAELYKYWSDLRFMEPCPIHFTEVELSQYEEELAKYEEWNDLQVLVKRALDTDSEGWISPAFDWNEKKTQHEELYQMFAKKMLAENKTIDEIKKMWPFPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7A6</accession>
    <name>D4D7A6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000153">
        <property type="protein sequence ID" value="EFE42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022883.1">
        <property type="nucleotide sequence ID" value="XM_003022837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7A6"/>
    <dbReference type="GeneID" id="9576922"/>
    <dbReference type="KEGG" id="tve:TRV_02987"/>
    <dbReference type="HOGENOM" id="CLU_421483_0_0_1"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="698" mass="76239" checksum="C45F426387690277" modified="2010-05-18" version="1">MLLTLKTSSRNGALALDECTRTKPAYAYQKHPHPSPSPSPSPPPSPLSSAPARRQMDSHRSLPPPAAMGLTVTDMTSAASHGGSSGSNGGTGSMPLPPPPTHSHQHVPGGGNHGRDGWSRDGQDDAMRQWLQAKVEEDKRKQEEERTRQEALKLDQRKIEQKMLQDTLSSNVPPHMVPLVFIGLAGPHAQWAQQYILQMTQNNGHNPSSSPYPVQQQRHDQYTQQYRPPPPPPPPPAFQQSSQQPPQPPPPPHPHPQQQQPLKHISQFPEFIPRPKQSPIEASENREIAPNPYAISAPRLSIPAGQHQQHQQHPQQHQPQPHHNQQHHQQQQQQQQQQQHPPPHHHQPRPPHQHHPQQPSPPPSHPPITIYAPNPAHHQPQMNTESLPRLSTASDMHHPIQQRNNSAPSSGAMSANTQSSLSHSHPSSSQSTSAKQDSTTAAHQVQQTSPSISFHHWVPPQSQPTTPAGKSPNSSPHSGHPASASSSQPHHLRNEYQQSPKKRKAQSSHAPIPPPPSQLSEVATTDETTSQTGRTPRNRSHSGAGAERRRQSSSAAQARSAGEYTFKINTRNNSTAHANPSPISKQQQQGSQPPAPAQTQMQVSSLVRPSDPNQTPTTSRSHSHSRDVSPSSRDTRDTTREREPPTVNEPDNTAPRGAIASTNSGSSGESTVSYHTASNSLTPNHTNGPVPNGDSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7D9</accession>
    <name>D4D7D9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000157">
        <property type="protein sequence ID" value="EFE42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022859.1">
        <property type="nucleotide sequence ID" value="XM_003022813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7D9"/>
    <dbReference type="GeneID" id="9581583"/>
    <dbReference type="KEGG" id="tve:TRV_03021"/>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="154" mass="17513" checksum="C2EC0BD1BE80BECA" modified="2010-05-18" version="1">MPFTAEDFNRAMAPSTDERRTYKGNCHCGNIRFMINNIAPLEKGKAVRCNCSSCVKHGYLLVYPRIEDVVFTHGSMDSMSEYRCATMSRPHKFCGNCGTPVMIQLEHGDTPHLRENIAVNIRTLEDVDEVLDKIQFLEFDGKHEIGEKYTLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7S2</accession>
    <name>D4D7S2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022695.1">
        <property type="nucleotide sequence ID" value="XM_003022649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7S2"/>
    <dbReference type="GeneID" id="9581353"/>
    <dbReference type="KEGG" id="tve:TRV_03156"/>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112319" checksum="91F4BE044FFA4BEB" modified="2010-05-18" version="1">MPFESNFIDLSLRLVLSPPDAPGGHRLGVNGLAVDTTSSTLYSAGRDGVICAWDLNLNLRTRNDLHDFTQNNTPSRSSTATSFRSQVQAHTHWINDIILTRNNSTLVSASSDTTVRAWRPAADDHAPAVIGKHTDYVKCLATPQPDADWVASGSLDHKIYLWDINGGGERLKIDVSEYDKTPKGSVYALSAKGSILASGGPDSIVRIWDSKTGKLITKFVGHTDNVRSILLNRDADTILTASSDQTVKVWSMAAGRCMHTLTMHNDSVWSLYSDHPQLSVFYSSDRSGLVAKTDTRNAPDIDQGICVAALQENDGVFKVVAAGGHIWTATPKSSIHRWSDVDITAEIEASAPSPLCRHTPSVASPTPSDDNKIDPLSSNQKIPASSILILSNAATFPNPMHREADVVSLSVSSLRAPTDILLDEGITLATPLQSLPQETIEGQHGMIKHIALNDRKRALTQDTAGDVVLWDLLRCVPIKFFGKRHLDDVASEVNTTETIANWCTLHTRTGRLSVILEQNRCFDGEIYVDQANLPDTDTNAYREDQRINFGKWILRYLFDGIVKEEVRRDEVYRQTLKLKYEQKGECDYDVLDNIALPTVATPSSPETPIPPSSPGMKGAGATRSAMAPGMSIGIGTPNMTSPFPELHNSSNGPFTNDGGKDPTGSSDYFTNAMKRPSTDAADSTAKSRSSDEQPPPAAPISGPLEPEKEERSKKGTTLFGKKFQMTFPKKSKTSTETKPIAEEKTEESDKSSEKERPFDDNFRGVIDRIHADYDAYSAANPCKEIETLITPTPENEAPVLNIPPHIGILIQEENPDSAVAADLYRGTVGTVRQDIEIFEKAAPAWLADLLLRNIVPFKEIPKIAFSLKPYQDSLPEVVKPDTAAPNNSSRLNANRMLRAKKILAYVAERIDPQNAETPSEDALKPEEYLELYCQNTLIPMDMTLATIRTHLWRTGNDMVLVYKANGKRKIPVPVEDGEAKDKKVGVDLSSTETTGADQRPQVNGKHTDTDATGATLAQSPPESDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7S4</accession>
    <name>D4D7S4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000163">
        <property type="protein sequence ID" value="EFE42079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022697.1">
        <property type="nucleotide sequence ID" value="XM_003022651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7S4"/>
    <dbReference type="GeneID" id="9581355"/>
    <dbReference type="KEGG" id="tve:TRV_03158"/>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="680" mass="76587" checksum="4500F0380DA21089" modified="2010-05-18" version="1">MLTYPLGVQSKVLTLQWPEGGLLTKKGFETQARMLRYQILGKACVKDDIRALLLGHHQDDNVETALMRISKGHRKLGLVGFDEIAPIPECHGLYGVSKSGLATSLQGILKSTNMDETISHPSSEIPSRSMNFAPGQMQVSTGGIYLFRPFRSFSKSRLVATCQENKIAFVSDSTNEDRTFTIRNTVRQLLNSENLLPRALQRPSILSLVDKSREQTEKFRELCESILKKVEVLSLDTRFGTMVVKMPMMSELPKHQINAVQARTPLPDGVRDVYASVLRSLCDLISPHPDRWSALSQFRNPAYRAFFGLDPSGMNGTVFTVGGVLWQAINQKTASKSNTKLLLSDLPSLQNLPGNLQLRDQDFTPLSAKQNNVWLLSRQPMHSGKPQPTINFALTIPDYLATKTKHGVILQKKGQKSRQQDVGKFIYTEWTDWKLWDNRYWIRIRGRTSIQQYDRSQERLGRSDKPLGKQKSKFPKYSPNSEIPIRLRPLSPADLVRIRKILGGAVKRSLDRDMAKGHFILDEERESRARSRRDSQDSALVTYLASQNPISATTTLTRPQGPVLPIAPSMFQKLLALLAPGKIRFSAPILTDVAPEIKDDESFENIQDQLLGMPSIPMSFRTKIRVRTPVRDTGGGRDDCTFDVPWSVEWEVRYKWIDPNTVQAVSWKAFDVPCQGSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Y9</accession>
    <name>D4D7Y9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022636.1">
        <property type="nucleotide sequence ID" value="XM_003022590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Y9"/>
    <dbReference type="GeneID" id="9581311"/>
    <dbReference type="KEGG" id="tve:TRV_03223"/>
    <dbReference type="HOGENOM" id="CLU_020925_1_1_1"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57935" checksum="3E2B10D457ECB179" modified="2010-05-18" version="1">MPGKKRASTSSRGVANLTAEQLAKKRANDREAQRAIRKRTRTQIELLEQRVRELTSLQPYQDLQEALRQKHILQAENNEIKRRLASVMATLQPILNHHSGPLTSTIPPLSPHNDVPSTRVHRPNSVANADIPPTPPPQSDYAGSQQQAPQGEPSDRRLRNPVSVESTNGGPGAYTSSPATSVSPSPSASSQAHGHRQSWQQNAPTSHNADNAWPPHNQLFDYQKRNLTHNLELSGNGERLGLNFLLDSTQNVPKVNDFRIGVGSSSANGPLSYNNRLNTPSYGDSNMCPYSIPIRNVEPTCPLDGILLDFLRTRQREAAEGVPNKQLVGPPYPSVSSLLNPAKGIYSHPLSKVFTDILSKFPNISNLPEQVAVLYVMFLLMRWQIYPTRENYDRLPEWMTPRTSQIVTPHAAWIDYLPWPRMRDRMVASYADYDFSNWFIPYTTGLSLNWPYEPTDTLLATNDSDELIINPVFERHLRDLNNWSLGTLFATTYPHLVDTTRIVPESNSQHKNRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z1</accession>
    <name>D4D7Z1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022638.1">
        <property type="nucleotide sequence ID" value="XM_003022592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z1"/>
    <dbReference type="GeneID" id="9581297"/>
    <dbReference type="KEGG" id="tve:TRV_03225"/>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60236" checksum="8683462FAA153B0C" modified="2010-05-18" version="1">MSPQSFSQAAHHSHTPRDEDQFNSSTSERRSSLSRRRAAAAGPSNISSSTDIRLRELKPANKSTTLFSADDGHTKSSYTSAEEDSDGDMAIGRPSMQRPGESRSKVPLLKGDSRGRSASVGPASMEEGRPSLSRARPSFRSKSPDFGAKNATRKKYIIAAFALFISLISFTVQTQTAVNIQQELGWNKPYCMLYLTHGSWIFLWPVQLLVLRIQKRHLTWSAFWRKHVYILQTTAQMVETQELHLTTRQSNKSPVPYMVRTTVFVALALTIAGGSWYVAVDLTTSSDLTAIYNCSAFFAYAFSIPLLNDKLRFDKVFSVGVAIVGVIIIAYGPGGPPEGTPAGDAETLKASNRALGNIIIGVGSVLYGLYEVLFKRFACPPEGTSSGRGVIFANTFGSMIGLFTLLVLWIPLPIFHLLGLETFQLPRGETAWLLIISTLSNASKYKSPSAIIFATGILTKYPPAFSGSFLVLISLTSPVLSSVAALLTIFLVTLVDWKFNHKALGFTSIVGGILITVAFLLLSWSTYRELDEERRKRMEDEGPDSESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z9</accession>
    <name>D4D7Z9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022646.1">
        <property type="nucleotide sequence ID" value="XM_003022600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z9"/>
    <dbReference type="GeneID" id="9581305"/>
    <dbReference type="KEGG" id="tve:TRV_03233"/>
    <dbReference type="HOGENOM" id="CLU_056802_1_1_1"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055653" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="291" mass="31979" checksum="1766D14A1C160A91" modified="2010-05-18" version="1">MRLFITIPILLGSLGSSSPIKSRSNSQVDIKASEQIRVGYFDGDTFYSPPFAPPRVKSNNELHEDGDEPVADTAIPDWPTTHLLARRLLAISSTAVLSTVYPKGYRDGTLEGTPIGLPDYIADCSAYDNNVALTNILGRGNPLLLALNIGTTFRNAKAGSKVSLSVDWWQHSRILPEGEDPLDRVPAGLPRLSLLGRIEEIQLSSLSKGDKEAIEQCFLKNHPDSKYWLPGSPKSPHSGYWARLVVEKAFWVGGFGDRARIGWLDMDAWKTVPENSKDGKKGWADIKLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D836</accession>
    <name>D4D836_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022614.1">
        <property type="nucleotide sequence ID" value="XM_003022568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D836"/>
    <dbReference type="GeneID" id="9581273"/>
    <dbReference type="KEGG" id="tve:TRV_03271"/>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="514" mass="57404" checksum="1BF84B833A83850D" modified="2010-05-18" version="1">MSPLHILQDSVIANAVFNPANCQIGAGSGGSSTAYYLRTYADYYSIPVNITIFEREDYVGGRSTTVNVFDDPTLPIELGASIFVEANKNLMKAAKNFGLEIQDAGVARPKEATDNLGVWDGSKFVFQQREGNYRWWNIVQLLWKYGWAPMRTQDLMKSTVGKFLKLYRYPLFPWKNLSEAARSSGLVEATWATGAEFLKENHISEAFSREIIQASTRVNYGQNLPLIHGLETMVCMAAQGAVSIQGGNWQIFSGMVEASQAVLKLESQVTSLKRAEDNTYTVSHNCKANKTEDEVFDQVVLAAPLQFSDIKLEPPVDDQPDNIPYMTLHVTLFSSPHKLSPKYFNLPLSNMVPETVLTTLPKGLNLGHRRDGVGPTGFWSISTLQKVRQPNTEEDEGKYHYVYKVFSPERLNAMFLSGILGLEGPINGTIADFPEADISWSYEKVWHPYPVPYPRVTFESIKLSPGLWYTSGIESLISTMETSSLSGMNVAALMVSEWTEDFNPKMNIFEGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D848</accession>
    <name>D4D848_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022626.1">
        <property type="nucleotide sequence ID" value="XM_003022580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D848"/>
    <dbReference type="GeneID" id="9581285"/>
    <dbReference type="KEGG" id="tve:TRV_03283"/>
    <dbReference type="HOGENOM" id="CLU_025360_1_1_1"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="237" mass="25562" checksum="D615EEB438458A27" modified="2010-05-18" version="1">MIYTSIKALQFLSVPVYTIFKNLTIVVIAYGEVLWFGGSVTPLIMLSFGCMVLSSVVAAWADIQAAVNGFGHSGETAAAISTLNAGYAWMGLNVICTALYVLGTRKFITSLNFKDWDTNLAKNFPAESRNNILIGMLYSGLGAIFISYSSAWCIRKTSSTTYSFVGYLNKLPLAISGLVFFDTPVTFGGVSAILLGFFSGLIYGYGKMKQKEMASQVLPTTRPTMSASSQSQKDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S2</accession>
    <name>D4D8S2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022299.1">
        <property type="nucleotide sequence ID" value="XM_003022253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8S2"/>
    <dbReference type="GeneID" id="9576902"/>
    <dbReference type="KEGG" id="tve:TRV_03510"/>
    <dbReference type="HOGENOM" id="CLU_998160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="279" mass="31493" checksum="D4E8C9E9B13DCE1A" modified="2010-05-18" version="1">MAAGIAVELRFLRSLMEVRLEVLPVVEDWKKKRQTQGGEAERERERERKAKKKKKRKKNNNNDNDDDVDQSAAGKRLTDGQTHDEESDKKAPLFEYSKTARRGRFMGSHDRSTKFLAGLKPALAATVETYEVRPGGFKRSGTRDATASGPGEMQAGGEAEPGAAERDNKRRNKRKREKGRDKDQGKLKNRRSVFNWRWILEGMERQKVKETEKDGRGGGETALVDKGGITATGRPFSDNTSDNETMQDYDADDRNRPAERSVGVEGRQLDHSSQATRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D931</accession>
    <name>D4D931_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein (Gyp3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022297.1">
        <property type="nucleotide sequence ID" value="XM_003022251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D931"/>
    <dbReference type="GeneID" id="9576900"/>
    <dbReference type="KEGG" id="tve:TRV_03621"/>
    <dbReference type="HOGENOM" id="CLU_005350_3_1_1"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="512"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="859" mass="94425" checksum="05D1C430543CF79D" modified="2010-05-18" version="1">MITQRGSRRPSADTRTASQAAAAASPSPSPSPASSASSVSSSPSPSLSPAVRKGASSARLRPLRQHQHQQHQQQYQNSPVGLRKASYAASFTESPTQIQPADGAGRGHGSPAATAPASGSASGGQPYQQHHQHQHQHQHQHQQQRFYQRPYSPQPRLKPSPSMPNVRQQKSYSPFQADKPSPRPSPMALSPSRPNNHRYYTPELHFDIPPPSRTSLQSAMTVASSVEQTSGTERSSVVTKTSSTTELSPKISEEDVQGGKQGDHRGQEDQLQHNSQEEGQGTLGYGDMSVDDAIDMYLDGFADDPSPGSPAKRKSAALVRALLSTGAGDDDDNNIIIKPASTPPDTPEPESLTPGNFNSADFNFDFAPSQPAGDKSPSPRPQTALPSPSASPPPPPPPDTAAAATTTTAATTSTDMQPPQKQLQPPFIDLSISSEPPPLLKPTKTRDQYGFRKATTHVTIEQYDSWYQSYAEYQKIRSEKWYALLKASGIDEAVPTTFPIRSAKLKKYIRKGIPPECRGAAWFWYAGGYDYIRRNPGLYRRLVETALRSPMNDDKEHIERDLHRTFPDNVHYKPDSSEDAGASSGSGSSNLKHSSSSPDTPIIQSLRRVLYAFSLHNSNIGYTQSLNFIAGFLILFLPEEKAFWLLHIITSSFFPGTHEISLEGANADLWILMVALKESLPSVYTKVVSTAPTTSRSKPPNLSTATRLPDITLGLTNWLMSMFISTLPFETTLRVWDVLFYEGSRTFFRVALSIFRMNQKQIVSLGDPMEIFQVVQTAPKRMIDPNELMMDCFARRFKLSQARVETLRQARRAAIREGKDRLSQLAGPRKFKTDPSGRPSTGANSSSPSAWRSFKSFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9G8</accession>
    <name>D4D9G8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000193">
        <property type="protein sequence ID" value="EFE41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022116.1">
        <property type="nucleotide sequence ID" value="XM_003022070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9G8"/>
    <dbReference type="GeneID" id="9579001"/>
    <dbReference type="KEGG" id="tve:TRV_03761"/>
    <dbReference type="HOGENOM" id="CLU_1961179_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="128" mass="13659" checksum="C55FE6ED6B551007" modified="2010-05-18" version="1">MGQVPSAPRAPLVLTSNKGAVSGGTEEKTEETEETEAGEKKKKGKKKKEKKPNCYRPGGQQHLGLKGQGSLVHLASSIRQKQTSTASAGGSKKDREARRESFFFSLLSTSCSSFSFSSSLSSPPHLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Y9</accession>
    <name>D4D9Y9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000202">
        <property type="protein sequence ID" value="EFE41328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021946.1">
        <property type="nucleotide sequence ID" value="XM_003021900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Y9"/>
    <dbReference type="GeneID" id="9578829"/>
    <dbReference type="KEGG" id="tve:TRV_03932"/>
    <dbReference type="HOGENOM" id="CLU_019189_3_0_1"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="391" mass="44729" checksum="C66295AA28DE93DF" modified="2010-05-18" version="1">MEHLKLILRSKTPLPIPEILLWSDDPSNPVGIEYIIQEHADGVNLHEHWPEMDMVQHMQCTKELSLQIREMASLDFPAYGSLYFADAPIEGKLKIPFDNGIDLKEYSAGLIDTALSRLPKEQPADDRLPFRGAVQEHSDLIDACRKSMNILIEDGRVQTAATPALIHPDYHKRNIYVSPDDPTKVTGLIDWQLASIEPAFIYVHGTPDFASLADQDPAEADESEKAQSEDERRLQKDLSICHQTYDVIMKGKIPKMRAATRLDPTFFRLFHYCFTTWRDGAPAIRQELLDLRSLWSELVLPGSCPYDPDEEELHRHAKQYEDFETRQKLKTWLTMQLNSGSDGWVPNEIWDAAQEANRAAYAEWMESAKELGEAEGMTPEKADRLWPFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA06</accession>
    <name>D4DA06_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021920.1">
        <property type="nucleotide sequence ID" value="XM_003021874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA06"/>
    <dbReference type="GeneID" id="9578803"/>
    <dbReference type="KEGG" id="tve:TRV_03950"/>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="165"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="686" mass="74303" checksum="1080F2F67D4BF96C" modified="2010-05-18" version="1">MTRYSVTVIDASVGHIVNQIPAENVYEIDFSPLGTYVITWQRPSKDENGDAVRNLKVWKVATDSETQDQQTPIGSFVQKSQTGWNLQYASDEQYCARVVTNEVQFYESGNLGTVWKKLRVEGVADFALSPGKGHAVATFIPERKGQPASVRIFDMPNFNAPVSQKSFYKGDKVQLKWNNTGTTLIVLAQTDVDKSGKSYYGETTLYLLSVSGTFDSRIDLDKEGPIHDVTWSPTSKEFGVVYGYMPAKTTIFNTRAVATHSFQLGPRNTILFSPHGRFVLVAGFGNLAGQMDIYDVEKDYKKIVTIEASNASVCEWSPDGRHILTATTSPRLRVDNGVRIWHVTGALMYNEDMNELYSVSWRPQSPNSHPLTSNPLNPVPTPHPSATAYLSTKKAPTKPAGAYRPPGARGQSTPLAFRREDEGGAAFVREDSSSFASNGGSAPSPFGKPRRRAVPGAEPVEEFLPPGAAPGGGVALPPGAEASAPGPEKLSKSAAKNKKKREAKKAKEASAGGQGDGGENSMAAATNSGRRDRSRSRHRQQASGGANGANGANLDPNYPRGGRDRSRSAHRRQRSDGRNSTPNRNGNGNQPHDRRSPAVNTTGRQQAAPPDLTVTSPDGGNTANAVPDAAAIARDKKMRSLLKKVRAIDELKMRVASGEKLEETQMKKIHTEDSVRSELEALGWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA42</accession>
    <name>D4DA42_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium dependent phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021897.1">
        <property type="nucleotide sequence ID" value="XM_003021851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA42"/>
    <dbReference type="GeneID" id="9578780"/>
    <dbReference type="KEGG" id="tve:TRV_03986"/>
    <dbReference type="HOGENOM" id="CLU_071162_0_0_1"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25304" checksum="1F8505FF5C6FCBE3" modified="2010-05-18" version="1">MVKNKGSNSAKVPLPLALEAPYAAPTTFNDGLPLPKIFVFDLDYTLWPFWVDTHVSAPIKAKDNNSRCVDRWGESFSFYPAVHSILQACRARSIPVSLASRTNTPDLARDVLKALHVIPSFTDNPAADNRSIRALDYFEHIQIYPGTKTQHFTRIQQSSGLKYEDMLFFDDEPRNKNVQAELGVTFCLVKDGITKEEVDRGVWEWRKRMGISQADRKSAEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA65</accession>
    <name>D4DA65_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021834.1">
        <property type="nucleotide sequence ID" value="XM_003021788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA65"/>
    <dbReference type="GeneID" id="9578714"/>
    <dbReference type="KEGG" id="tve:TRV_04009"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_33_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="393"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="756" mass="82132" checksum="7DFBC9839E47BC6E" modified="2010-05-18" version="1">MAATSTSTSTVGVDVKKPPPLMDIPAALAASPTASRPTLDLPDSLRCSDLPGVIHEEDEESATEPSEPVTPTSLTHHNHHNLFSGPHSYQSQQHPRIDPPSRDPMVSVNVPVEVLKNPIIVNTEPTPPSTPSRRPPTTQAQAPAPAPASNPTSNTTATSTSATSAPVAIPPPARPSTSASQKSSPLRKASKSIKGIFRRPSTSDAMPPTTTPANNTAAAAATGNAAPNAQTEQKKLSLNMFQASNTRKGSVSSSHQHSPTSSRTNSPQSPSSPSSTLHGNSNPQNPMYLGVTPPSDSSFNPRRPARSSTGLSLRERSRVMFGSTPRPQRDEDQRIRSPSLGDVQNQPERPGFSIPAVSGAGLKARRMSTSLPDDFDVNTCPLADEYTNSSKLPGKRKEVGRGATATVKIMCRRGSDKSELFAVKEFRKCGSKEDQHENEQKVKSEFSIAQSLHHPNIVESFRLCTSNGRYNHVMEYCSYGELFSLVQKNYLQPKDNHCFFKQMVRGVAHLHENGIAHRDIKLENLLLSDDGYIKITDFGVSEVFSGLHPGLRSSGGECGKEMGEVRLSSPGICGSLPYIAPEVLAKQSSYDPRPLDVWSCAVVYLTLHFRGNLWPSASREHPNYARFTSGWEKFLASSETGIPSEDKMPSCGPAFRHIGNRNLKLLLLKMLHPDPAKRITIKEVLGDRFMKSVECCAPETKKGEEQIEAVGAGIDAAGKASSKRASKMVIQKIHHHFPPEKKYLPQYRFDMGDGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAG6</accession>
    <name>D4DAG6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021782.1">
        <property type="nucleotide sequence ID" value="XM_003021736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAG6"/>
    <dbReference type="GeneID" id="9578662"/>
    <dbReference type="KEGG" id="tve:TRV_04113"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="427"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="805" mass="91981" checksum="33DAB82024DB1698" modified="2010-05-18" version="1">MTGRNENDDFASIWNILASSIREIHTKNSSQLSFEELYRNAYKLVLRKQAMDLYEKVAELEKDWLYNDVRKQVASLITPALLTITDSADATEHANERKAAGERLLAKLKEVWEDHQLCMGMITDVLMYMDRVVMQELRSQSIYDTSMGLFRDCVLRADIGGENGTIGSVFENTLLFMILLEREGVIIDRALIKHCVYLLEGLYEDGIEDSTGKLYHTTFEPAYLEASRRYYAAEGQRLLTTTDAATFCKRVTARIRAEQSLCQQTLSPVTEAKVMEVIDDCLIRHYIGEVIRMDDSGVKYMIQNDRLEDLKNVFELIARIDAKKVALTKVVQQTVIEYGTAVNTAAKELSQNPPAPSATDQGKKSSAPDEKQPVANLQTAAAIKWVDDVLKLKAKFDRIWEEAFVKDQALQTALTLSFSDFINVNPRGTEYLSLFFDENLRKGIKGKTEEEVDALIDNGITLLRYIRDKDLFETYYKKHLSRRLLMKRSASMDAERQMITKMKMEVGNTFTQRLESMFKDMAVSADLTTSYRDYIGNNSRIELEMSVLTSTMWPMEIMSSHNREGQVQLPCIFPKNIESLKQSFERFYLDKHSGRKLSWLPGMGTADIRATFMRQNGKVERHDLNVSTYAMVILLLFNDLPSGESLTFEEIQEKTRIPTNELIRNLQSLAVAPKTRVLRKEPMSKGVQPSDKFSFNEQFTSKFTRLKIGVVSASGNKVENKEERTDTEKKTSEERGNTIEAAIVRIMKQRKTLAHSQLITEAISQLAARFTPDVNMVKKRIESLIDREYLERITDSDPPAYSYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAP2</accession>
    <name>D4DAP2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021679.1">
        <property type="nucleotide sequence ID" value="XM_003021633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAP2"/>
    <dbReference type="GeneID" id="9576762"/>
    <dbReference type="KEGG" id="tve:TRV_04190"/>
    <dbReference type="HOGENOM" id="CLU_076154_0_0_1"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="207" mass="23487" checksum="5194795A6068BF0E" modified="2010-05-18" version="1">MTTQAAVSLVEGLPLRLRNFFARYPPQYYSSQAIPKVLPQQETFSSSSESSAVIKPAPSPFASRNTKVKLSKTKDADSVSYTDSLLRSDPSGLYPNPFLPYKNPETGRWRGAVISLRRQAELVKLGIKYGVEELLPPGRKSTEYKHARLIEKGLRVKGTGIGQKVKGHKWERSMKGKLEERKKAMLEMPEMIRLWKQVRLHIRFCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS5</accession>
    <name>D4DAS5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021643.1">
        <property type="nucleotide sequence ID" value="XM_003021597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS5"/>
    <dbReference type="GeneID" id="9578604"/>
    <dbReference type="KEGG" id="tve:TRV_04223"/>
    <dbReference type="HOGENOM" id="CLU_079426_0_1_1"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="29880" checksum="5D8D249F6CB4940A" modified="2010-05-18" version="1">MENPVEEIPQVIHLLTQSIPSVQQQTVEKYFTPSASITHPFLHSGSFQGSRWLISRIFLFYKIMSPHVDLQVKSVGQYPTTNALVVHARKVAPYLTCIIAFDRDNLLLYVTVSQVFRIFIVPFYTAPVTLTTVLQLVKGVEQDSPAQHRHKVPVVELTNSNTDLLASSTSIPAEEYASTTVEPCSSTKPLYYIASQNDLYQTNEYVKFVIPYGIGEAFVLFWHAFATLFCVLASYVFWPIAWAEEKGILQVTRFDSTLHKAKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAS7</accession>
    <name>D4DAS7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021645.1">
        <property type="nucleotide sequence ID" value="XM_003021599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAS7"/>
    <dbReference type="GeneID" id="9578606"/>
    <dbReference type="KEGG" id="tve:TRV_04225"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_5_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="325" mass="35663" checksum="9AA08D916BB16FB3" modified="2010-05-18" version="1">MPRVITIIGATGNQGGSAARSLLQNPSFKIRAVTRNPSSDASKALASAGAEVVQGNGFNHEEMLRAFEGAWGLYLNLNSDDEIWSNPNGPTEFDLGKSIIDAAARVGVPHLVYSSGPPCVEMTDGVVRMKAMEMKYKTEQYAKESGKFQTVTPINAAWYLENFLAKEIAPAFGGFPFFPDDEGYLSYKVPHWGGDNRVPYLSITDDYGDIVHGVFLDPTRWKGQVIQAMSDMITFDELAANFEETTVTGKKSRFQPVLPSWEAYDTHGVPELEDVKLMFGFTQITGGRYFGPEPSDITVSKELKRATAKALGKPEDEGTLKPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB54</accession>
    <name>D4DB54_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021506.1">
        <property type="nucleotide sequence ID" value="XM_003021460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB54"/>
    <dbReference type="GeneID" id="9578454"/>
    <dbReference type="KEGG" id="tve:TRV_04353"/>
    <dbReference type="HOGENOM" id="CLU_676105_0_0_1"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="407"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="503" mass="55918" checksum="30504FC55CC4862D" modified="2010-05-18" version="1">MFSPRRLRLYLISAVILVCFILYFTGDVRRTQALRAAGTSQPGKSNPNLKGSSGSYGNDKDNDGGVFDKLKPGSLRSGDKQKPVKVEEPEQTPTSAKKEKGKGKDEEEATDDAKSEDDIVNEEMNTILKRSPIIIFSKSYCPYSKKAKYFMLEKYNITPAPFVVELDEHPLGRQLQDLLGTNTGRRTVPNILVNGKTIGGGDDIEALYLSGELGTKLQALGGKRVTAVGINRYQSISININFVAFFSFPKGKHITDRKTSKAKLRKVNEAKKNDEAHQRRQTTFNSPVSPSVSFFTGGVKMLYIHSQETLQIPENVNLHIRSRIVTVEGPRACTYTGFNDAGKLVKDLSHLSVCFSRPKKDTIAIEVHHGGRKAVATLRTVRTIINNLIIGVTRGFKYKMRYVYAHFPINVNIETNKETGAVELEIRNFLGEKVVRRVVCQKGVEVVASSNVKDEIVLSGNSVESVSQSAADIQQICRVRNKDIRKFLDGIYVSEKGNIVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBB5</accession>
    <name>D4DBB5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000221">
        <property type="protein sequence ID" value="EFE40855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021473.1">
        <property type="nucleotide sequence ID" value="XM_003021427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBB5"/>
    <dbReference type="GeneID" id="9578434"/>
    <dbReference type="KEGG" id="tve:TRV_04414"/>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="420" mass="49131" checksum="113B30D904995AAD" modified="2010-05-18" version="1">MLTRDFIEDSLYNPHYGYFSKHATIFSPGEPFDFNNIEDGPTFNKLLDQRYVEFEDKLDETNYDETRQLWHTPTELFRPYYGEAIARYLVTNYKLTLFPYHDLIIYEMGAGNGTMMLNILDYIRDVEPDVYQRTKYKIIEISSSLANLQQQNLNHSIHAGGHGGHAEIINRSIFDWNTYVHSPCFFLALEVFDNFGHDVIRYDMETGQPRQGCVLIDSDGEFYEYYVPDLDRSAARFLRVRQAAARRPFTTPLGPRLWRKLQTALPFAPNMTLPEYIPTRLMQFYDVLHDYFPAHRLIASDFNSLPDAVPGFNAPVVQTRYQRRNVQATTPYVSNLCNLFLVIMLTLLFLQVHQGYFDIFFPTDFNVMEDVYRAITGKLTRLTGHDDFMRRWAYLEDTQTKNGENPLLGWYKNASVMITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBF9</accession>
    <name>D4DBF9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021385.1">
        <property type="nucleotide sequence ID" value="XM_003021339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBF9"/>
    <dbReference type="GeneID" id="9578264"/>
    <dbReference type="KEGG" id="tve:TRV_04459"/>
    <dbReference type="HOGENOM" id="CLU_031403_0_0_1"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="36716" checksum="A9BDBBE77DCFAF0C" modified="2010-05-18" version="1">MIVEAKFIASVVEEYGPCMSSPKIRVTSFFRKYLTRGQTSCKAPELEAFEKYLPSDVEILSCHSLHGPNVNPKGQPLVLIQHRASNESLKFVEEIFRSFQSTYVYLSGEMHDRITADTQAVTHAAFLSMGTAWHANSQFPWEVPRYVGGIENVKINITLRIYANKWHVYAGLAILNPAAKKQIRQYAESVTELYKLMLGGHREELTKRIKTARAAVFKSNSARQDLLLQDNVLDRFSLSKGGTERMPNNHLSLLAIVDCWWKLGIVPYDHMICSTPLFRLWLGVTEYLFQNEELLDEVIDTAIEDNTFRSDDLEFTFAARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBH3</accession>
    <name>D4DBH3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_04473</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021399.1">
        <property type="nucleotide sequence ID" value="XM_003021353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBH3"/>
    <dbReference type="GeneID" id="9578278"/>
    <dbReference type="KEGG" id="tve:TRV_04473"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="295"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE40781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="481" mass="53079" checksum="25841889A99C6942" modified="2010-05-18" version="1">MASENPAAGTPLAERASFAEPKGKEVDTKPEESSGGVEDAQTDGAAYRTGASMLRDSEYTVNVQLSDLQADPNNPLYSIKSFEELGLDEAVLRGLRQMRFSRPSKIQERALPLLMSNPPQNMIGQSQSGTGKTAAFVLNVLSRLEVTPEMINVPQALILAPSRELARQIVGVVQVMGSFIEGLKIATLVPMETNRNQPVEASLVVGTPGTVQDFIRKRLFNTQHVKALVLDEADNMLDQQGLGDQCIRMKSSLPKNTQIVLFSATFPDSVVRYAHKFAPNANQLTLKHEELTVEGIKQLYLDCDSTEHKYEILVKFYGLLTIGSSIIFVKTRASAVEIERRMVEEGHTVVSLTGGVEGQKRDEVIDSFRKGTAKVLITTNVLARGIDVQTVSMVINYDIPELHAPGAGERIADPQTYLHRIGRTGRFGRVGVAVSFVSNKEEWTMLMDIQKYFGTDIMRVDSRDWDEVEDVVKKVIKPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBT7</accession>
    <name>D4DBT7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_04588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021275.1">
        <property type="nucleotide sequence ID" value="XM_003021229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBT7"/>
    <dbReference type="GeneID" id="9578149"/>
    <dbReference type="KEGG" id="tve:TRV_04588"/>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE40657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="477" mass="51255" checksum="B0E9F72C4DD5F9CE" modified="2010-05-18" version="1">MQGWRIAMEDAHAAVLDLQAKYTDLDRSSSSSSHHGAGGPTPADKRLSFFGVYDGHGGEQMALYAGENVHRIVARQESFARGDIEQALRDGFLATDRAILEEWCVIFISLDGYHTPTYIWQANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRALGDFEFKRAADLSPEQQIVTANPDVTTHEVTEDDEFLVIACDGTHHHFLPSLLATTNNNHCIGIWDCQSSQAVVEFVRRGIAAKQELHRICENMMDNCLSSDPETGGLGCDNMTMVIVGLLHGKTKEEWYNTIAERVANGDGPCAPPEYASFRGPGVRPQFNEGSDYDSAGPAGRSGRIILLGDGTEVLTDMGDEEMFDSADEDKDLESQVRRTTDADADADEAGETNDAAETERRQQREGTPGPQSTASNANSVDSASVSTSATSAPIAALTESPRVISASPLPTADSSPNSVSDTKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCC4</accession>
    <name>D4DCC4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021104.1">
        <property type="nucleotide sequence ID" value="XM_003021058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCC4"/>
    <dbReference type="GeneID" id="9577946"/>
    <dbReference type="KEGG" id="tve:TRV_04777"/>
    <dbReference type="HOGENOM" id="CLU_064135_1_0_1"/>
    <dbReference type="OrthoDB" id="4940591at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7735" evidence="2">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="287" mass="30644" checksum="5C54F117E5C807B0" modified="2010-05-18" version="1">MCSGLRRCSAEKKLAVIIIYKKRDELYSAPFHAAQPISISFTRSYIAFTAPIRKMRATFTLLLAAIAAAKDITDDDITIILPNERPTVTIDPWQCLTQNLTEYFDVPRPTGAFYSAVYSHGSELIKDCVAATKGVDCPFPESSDWCSLSTSIPASVLPAYSAYGSVASVWWKSHSSAVFTAAEMCPLGWFDAMLSIPGGRAWMNLTRIYGGCYAHAQPTPGSEPSKRLSTTSGPTAMPDAGASATGHSQPTATPMKNSIFGRAENRPGSLVAAGAGLAAAFISSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCE2</accession>
    <name>D4DCE2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000244">
        <property type="protein sequence ID" value="EFE40464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021082.1">
        <property type="nucleotide sequence ID" value="XM_003021036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCE2"/>
    <dbReference type="GeneID" id="9576729"/>
    <dbReference type="KEGG" id="tve:TRV_04795"/>
    <dbReference type="HOGENOM" id="CLU_117316_1_0_1"/>
    <dbReference type="OrthoDB" id="4174143at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="130" mass="14580" checksum="60DD112C616E2028" modified="2010-05-18" version="1">MHFRLGAEELSSRAGETPPYPTVNDMITDVQKGIDHLSGLLHLVTDEPHEELTYSRLLHALVRVSTSAAAVTKHIDENLGTWKAKDIASMDDEVERYELVPGVINVTMTEGNDHYVLVPETTRMTLEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCG8</accession>
    <name>D4DCG8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021071.1">
        <property type="nucleotide sequence ID" value="XM_003021025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCG8"/>
    <dbReference type="GeneID" id="9576718"/>
    <dbReference type="KEGG" id="tve:TRV_04822"/>
    <dbReference type="HOGENOM" id="CLU_1490052_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="181" mass="19476" checksum="5831629CEC2A7112" modified="2010-05-18" version="1">MAPLPDADVDAISASSLRSHKSPTLALMSWNIGLASRQRYITLSYYHSSIRLPTYASIAAAVSTIPPPAAALLSILYVGLRLHVQTFISTRTNPPLAVGQQGDEVSAVMGMPNSLFSAEGAPVLPCFNPDLMEFFGHNLPLVLKSSAGTEILLSRAKARNFGHHFPFLPLLLGKSHVVSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCL4</accession>
    <name>D4DCL4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine-rich secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021004.1">
        <property type="nucleotide sequence ID" value="XM_003020958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCL4"/>
    <dbReference type="GeneID" id="9577856"/>
    <dbReference type="KEGG" id="tve:TRV_04869"/>
    <dbReference type="HOGENOM" id="CLU_045407_0_0_1"/>
    <dbReference type="OrthoDB" id="4662630at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056166" evidence="1">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="331" mass="35845" checksum="E22529D6E5D56D22" modified="2010-05-18" version="1">MKFIYLALLSNLLNSPSLAHSANVAVRKIGKDAIIKDNKVTWMGEDGFQDSFSCPDTHVLQPSADQKSASCCLPGLTLKGSSTTSFDCCAEGHDLAGSEAVGYICCPTGQIYDGKVCKNGKPLVEGKCACSEDKNVTSEGCCEPEECSSGLKTGKCYTFKESNGYLLGYLRTGKYYNAAPDSRDRIFGKFQLCRDQLCNPGRPINAGDELYIKDLHGTPMDGADAGQWMNNAADGPHIGKTPNFAMAGRFAITKWPCGKYCITGAELGLGPACPADQPALTFYTRSSEPCVPYELTEVPCSVRSIKNNCIWYNGKDQCCDKIDCSERKCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCM5</accession>
    <name>D4DCM5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021015.1">
        <property type="nucleotide sequence ID" value="XM_003020969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCM5"/>
    <dbReference type="GeneID" id="9577867"/>
    <dbReference type="KEGG" id="tve:TRV_04880"/>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="178"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="690" mass="76662" checksum="B5D72597D71DAFE8" modified="2010-05-18" version="1">MVLAKSKNSVGLGNSLMNDRFGKGKRSDRKKVSHNVAAIQRKGTDGETYITNPTEEASWVKMRSITEQAALDEFLSTAELAGTDFTAEKLNNVKIIHQDQKNPYLLSAADERNAIRKHQKNRSRLTVPRRPKWNERTTRNELDAMERESFLDWRRGLAELQEVQDILMTPFERNLEVWRQLWRVIERSDLVVQIVDARNPLLFRSEDLEKYVKEVNPAKRNLLLVNKADMMTLKQREAWADYFEEHNISYKFFSAALAKELNEANGVGSGSDDDDDDVDTALAEQTSNAHIQDSEEDSEAAEEAGEEEEDSEEDDDGGGLPLPQESESKRTEIITVDELEALFMSAAPPRDPNDEKGKDVTTIGLVGYPNVGKSSTINALLGSKKVSVSATPGKTKHFQTLYLTPKIVLCDCPGLVFPNFATTKADLVVNGVLPIDQLREYTGPAGLVAQRIPLHFLEAVYGMKIPIRSIEEGGTGVPTASEILRAYARARGFATTGLGQPDESRAARYVLKDYVNGKLLFCHPPPKDPPFTDPKERSDYELEFNEGLYDMAHLPARRKEALLKEHAAAIRSDSVDGISDDIDLDSDMAPSHVSGNSSIPAQSARSKKLDKGFFGPGGAGSAGHLTMPFNYKYSEVGKQKAITGRKQRALIALEKNIDVSEVRGPGKKHFKANRKVKTKKKGNSFLAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCN0</accession>
    <name>D4DCN0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021020.1">
        <property type="nucleotide sequence ID" value="XM_003020974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCN0"/>
    <dbReference type="GeneID" id="9576667"/>
    <dbReference type="KEGG" id="tve:TRV_04885"/>
    <dbReference type="HOGENOM" id="CLU_560421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE40402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="487" mass="54156" checksum="4E7183AFADCA03CF" modified="2010-05-18" version="1">MAGHYDGPLDMPIELIYPFDGLPDGSTIVDIGGGNGQNAIRLVKSYPQLAAIVQDHVSVISNAENMVKESYREEIASRTTWEAHDYYAQQPQKGADIYLLSHVLMDNSDEKCVKMIQEVAKVMDPAKSKLLIHDFVDLPRTVGEGARLIEMLDLHLIASLNTHSRTELEFDSIIERAAGDLGLARVKTWPGRGSAVLELRLQSTDDVTSLRSMTGPNISNSLTAAISGTALPLIDKQAIVNYLGALAAGVIVLFLSLIAVHHLFTKLHAYIILRHIPGPPLAHLSSWLHRRAILRYTPAQWYHDVIEKYVAKIAPNLIVTSSPEVWMHVTTKPGYPRSEWFFRAMRVDYQHDHLFSLTDTAEHDRRRKLLGPGFHGTECSYELCINERLEELLLLIRSKYLSSDSKVVPMDIAAKVQYFTHDVITAITFGKSFEMVQKDADTNGYIKSIKEGFLTANILVAFGLAKISQSSLIGPALTPVATEETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCY0</accession>
    <name>D4DCY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_04986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020910.1">
        <property type="nucleotide sequence ID" value="XM_003020864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCY0"/>
    <dbReference type="GeneID" id="9577731"/>
    <dbReference type="KEGG" id="tve:TRV_04986"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="199" mass="22877" checksum="B136342574B07D14" modified="2010-05-18" version="1">MANTLDTDAGSELFSSYEAELKLVQADLNQKLDQIAEASGEERKAAIRQAERALEEANELLDQMRMEKENIPSSTRSKINSRFRNYLTDVDNTKRKLRSLSDDRKALFGERYTDDPNSTHDQHLEQRQQLLSGTERLERSSARLQDSQRVALSTEEIGRDTLADLYRQRETIEHTRAGLLESEGYVDRSVKTLRGMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD19</accession>
    <name>D4DD19_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000255">
        <property type="protein sequence ID" value="EFE40248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020866.1">
        <property type="nucleotide sequence ID" value="XM_003020820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD19"/>
    <dbReference type="GeneID" id="9577705"/>
    <dbReference type="KEGG" id="tve:TRV_05025"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="499" mass="56328" checksum="8A7122FBA6FB4703" modified="2010-05-18" version="1" fragment="single">GTRLEGTFLPWSLDLRKHLLDKFPLKEGQHPIPDDVRLPPKWILDHYDLKDEDGETRPKQPSRAKEANSPDHDTRPLPGSISATLTDNTRMTPSDHWQDVRHLVLTASESIKYAPGDILHITPRNFPQDVDRLISLMGWEEQADIPLQFVTGDGSLASASVSAPSIPFLLGSPGFTLRTLLTDYLDIMAIPRRSFFSQFAHFTSDEMHKERLLEFTNPEYIDEFYDYTTRPRRSILEVLAEFDTVKIPWPSVCSVLPVLRGRQFSLASGGKLKTSARGGTRFELLVAIVKYQTVIKRIRQGVCTRYLASLQPGSTLKVQVQKGGLHSSAKQLSDPSVLIGPGTGVAPIRSLLWEKAAMAEEYKKNQNRGPDEQPLTLGPVILLYGGRNKAADYFFEGEWEELKTQLNLRVITAFSRDQKKKYYVQDALRENSSMFYELLHEKGGSVFVCGSSGRMPQAVREALIEAFQAPLGDSAESRQMAEKYLIDMEKVGRYKQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDB5</accession>
    <name>D4DDB5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05123</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="ACYE01000261">
        <property type="protein sequence ID" value="EFE40151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020769.1">
        <property type="nucleotide sequence ID" value="XM_003020723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDB5"/>
    <dbReference type="GeneID" id="9577468"/>
    <dbReference type="KEGG" id="tve:TRV_05123"/>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="252"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE40151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="547" mass="58807" checksum="E65D15D77FB4C18F" modified="2010-05-18" version="1">MDDAGSAPSHSRSVSIPPAEAASRHLELALQRVVNHRAKSNRAAHTAKMIEQRQAATETAVSAPGKVLLAGGYLVLDRDYTGTVCALDARIHVVVQQQSVKRRPSAAETQTEGHAQLNSGQAAGDGAVGTAEIPPAGIVNGGAQEEGVQDTITVKSPQFVDAVWKYKIQRSDNGGGVRAVQCDDGPRNPFVETSLNYALTYVSYVSASHNIGSLVVTILADDDYYSETTASGSSNSGYAGFKKFGVRLQDAHKTGLGSSAALVTALVSALVVHRTVQPEKLSQNKAKLHNLAQAAHCAAQGKIGSGFDVAAAVYGSCYYRRFSPSVLAGLGEPGSAGFEDRLFAVVEDVNAGAPWDTECHDVGFKLPMGIRMVLCDVDCGSQTPGMVKKLLRWRDENREEADIIWANLQLNNEMIRFELRKLLHSPGADFNELRNLLLKSRMWIKTMTKKSEVPVEPMVQTELLDSLGKLDGVIGGVVPGAGGYDAIALLMIDDPEVYNEVRAHLKDWHSTVEDDFGGKIERVRLLGVGYGSEGILNELPVRYSGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDG3</accession>
    <name>D4DDG3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05174</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000265">
        <property type="protein sequence ID" value="EFE40105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020723.1">
        <property type="nucleotide sequence ID" value="XM_003020677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577422"/>
    <dbReference type="KEGG" id="tve:TRV_05174"/>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="756"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="491"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="635"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="909"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1431" mass="160655" checksum="013E710297184A08" modified="2010-05-18" version="1">MASASSRPRRSVSRKSFVLEESSDDEPASGRVTPSIPSNDEDEDEEDEEEEYTPVPKRRVSRRVSKAPVEEPTTPTPAMGRSNRRRSRMSGRESTVSTTDESIVSVEEEPEVRSRRTSKARQSIPRSQSSRHSSIEVSSLPTPAPSQSPEADRAQSRRLSGTPLADITENAVNQTPPNAPDVEKSVIERVDPSSSVLERPMDIMLKSRSAPQIVEEEPSGPKQRMVITHLVLTNFKSYAGQQFVGPFHASFSSVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKISALIHNSANFPNLPFCEVEVHFQEVIDLPDGGHEVVPDSQLVVSRRAFRNNTSKYYMNKRETNFTTVTEFLKGRGIDLDHKRFLILQGEVESIAQMKAKAANEHDDGLLEYLEDIIGTSKYKTPIDEAAAEVEVLNETCNEKNNRVQHVEKEKASLEDKKNKALAYIKDENELVEKQSALYQIYIDECNDNTNVTQEAILQNQDLLNLELEKHQGNEDEIKQLQRTYKKAAKEYEAMEKETQGIMKEMAKYDKESVKLEEKRKFLNNKQKKLEKSMNTSRLAASECAGLVEKHSDDFEKKSAEIAALEKEMKIEEKELAEIRESLKGKTQGLSEQIAAKQTSLEPWKEKINEKQSAAAVAQSELDILREKGNAGAVALEEAQAKIVSIKEDMSAKTAELEQCRAEKANLEHEVATCSANVQKFADKEPEYRSRLSHLRQKADEARASLSSTQTQGNVLSGLMRLKESGRIEGFHGRLGNLGTIDEKYDVAISTACPALDNLVVDTVEVGQQCIDYLRKNNLGRANFILLDRLPRRDMSSVFTPDSVPRLFDLVKPVDDKFKAAFYSVLQNTLVAKDLQQANKIAYGARRWRVVTLDGQLIDVSGTMSGGGTRVARGGMSSKQVAEVSREQVAKLDADRDAMEKKFQAFQERQRELETELKTTKDAIPKVETAIQKLQLEIDSAKRNLADTQRRVKELSEEHKPSAADEKREASLEKTIKALEKEIEKLRSEMTGVEEEIQALQDKIMEVGGVRLRGQKAKVDGLKEQISLLTDEVSNAEVSKSKNEKLRVKHEKSRADAEAELESVQEDIEKLNEEAKNQAKAVSGIKQKTEEAEEALQTKQEELTALKTELDGKTAELNETRAVEIEMRNKLEESQKALVENQKRAKYWHEKFSKLSLQSISDLGEEEEAPESLQIYTKDELAEMDKESLKAMIAALEEKTQNTSVDLSVLGEYRRRVAEHESRSADLATALASRDAAKSRLDTLRSLRLTGFMEGFSTISLRLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHHYRPTPLYVMDEIDAALDFRNVSIVASYIKERTKNAQFIVISLRNNMFELASRLVGVYKVNHMTKSVTIENRDYIEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDK6</accession>
    <name>D4DDK6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000266">
        <property type="protein sequence ID" value="EFE40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020691.1">
        <property type="nucleotide sequence ID" value="XM_003020645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDK6"/>
    <dbReference type="GeneID" id="9577390"/>
    <dbReference type="KEGG" id="tve:TRV_05217"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="476" mass="50822" checksum="3067D30C62324B1B" modified="2010-05-18" version="1">MKLHTDPSTGKLIGTCPEFTPADTHKAIDAAVSAFPSFRKTTGRERARMLRRWHQLMIDNAEDLATLITWENGKPLADAKGEVNYAASFFEWFSEEAPRIYGDTIPATVPGNRTMTIKEPVGVCGFITPWNFPAAMITRKIAPALAAGCTVVAKSPGETPFTANAIAELAARAGIPKGVVNIVTALKNTPEIGLSLTTAPEIRKVSFTGSTAVGKLLMKQSASTMKKLSFELGGNAPFIVFDDVSDVDAAVAGAIASKFRSSGQTCVCANRLYVHRGVYDEFTSKFAEKVGGFTLGHGFNEGVTHGPLIHSRAIDKVHEHVSDAQAKGGKVIIGGNRAPELGSNFFFPTVVTEMTKDMRMASEETFGPVAGIYPFETEKEVVDLANAAEVGLAGYFYSRDVQRIFRVAEALEVGMVGVNTGIISDTVAPTTLADLKSRFGGVKQSGFGREGSKYGIDEFLTIKTVTFGGMGGDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDN0</accession>
    <name>D4DDN0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000267">
        <property type="protein sequence ID" value="EFE40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020643.1">
        <property type="nucleotide sequence ID" value="XM_003020597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDN0"/>
    <dbReference type="GeneID" id="9577347"/>
    <dbReference type="KEGG" id="tve:TRV_05241"/>
    <dbReference type="HOGENOM" id="CLU_049131_3_3_1"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="130" mass="14889" checksum="4007264EA685A424" modified="2010-05-18" version="1">MINQYLRGEIQLDDHAVHLLFSANRWEAAAQIRQDIESGITVIVDRYSYSGAVYSAAKENKELQLDWAWRPEVGLPRPDIWFFLNISIEVAAARGGYGTERYETVNLQKKVGKLFLSLTELKGNEDMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDR1</accession>
    <name>D4DDR1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000270">
        <property type="protein sequence ID" value="EFE40006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020624.1">
        <property type="nucleotide sequence ID" value="XM_003020578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDR1"/>
    <dbReference type="GeneID" id="9577323"/>
    <dbReference type="KEGG" id="tve:TRV_05273"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000219">
        <property type="entry name" value="tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="266" mass="29819" checksum="FD33AC99C03E187A" modified="2010-05-18" version="1">MKVNAMASNSESYEEEHVHKVYQEIAPHFSSTRYKPWPIVERFLKDIPSGSIGLDVGCGNGKYLKVNSNIFIVASDRSEALTKFARQHQPHSAIIADTLSLPHPDGFFDFAISIAVIHHLSLPERRIRAIAAILNTLKPPALEDPNGGKVLIYVWALEQKDSRRGWDADHEQDVMVPWVLKTNGGKAKNTKARGMNKAESLEISADEAGKTTEPEKKPEPTTYLRYYHLYREGELENNIAAAGGRVLESGYEKDNWWAIACPLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDV4</accession>
    <name>D4DDV4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000273">
        <property type="protein sequence ID" value="EFE39978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020596.1">
        <property type="nucleotide sequence ID" value="XM_003020550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDV4"/>
    <dbReference type="GeneID" id="9577295"/>
    <dbReference type="KEGG" id="tve:TRV_05318"/>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12648" checksum="4813B4936590AD22" modified="2010-05-18" version="1">MGWFSSSTEPAPKKAADGGSIAPDRTSRQQCWIGRDKFFACLDANNIIDALKEDSAARSKCSKEIQEFESACSATWAKYFKEKRVMEHRRDQTIQRIKREDIESAAAQKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDW1</accession>
    <name>D4DDW1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000276">
        <property type="protein sequence ID" value="EFE39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020573.1">
        <property type="nucleotide sequence ID" value="XM_003020527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDW1"/>
    <dbReference type="GeneID" id="9577278"/>
    <dbReference type="KEGG" id="tve:TRV_05325"/>
    <dbReference type="HOGENOM" id="CLU_959781_0_0_1"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar GTP-binding protein 2 N-terminal" evidence="5">
        <location>
            <begin position="79"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="326" mass="36328" checksum="F889CE4A4C97D85B" modified="2010-05-18" version="1" fragment="single">RQLQRQLQREALNCKAPLETDTLLSSSRVSCYTSVKMGTGKKEASRRERQGKSNDGMGNVRTKGENFYRDAKKVKTLNMFKDGKAQRNASGKITKAASYQSRDKPSARIEPNRKWFGNTRVISQEALSSFREAVAEKAADPYQVLLKTNKLPMSLIQDGHAPNGLKQHKAKIAVENAPFSDTFGPKAQRKRVKLSVDTLEGLAGETVKMYDSYLDRLEQAKLLSGTSGDANADTNGDDAELTAAREPIFSKGQSKRIWNELYKVIDSSDVIVHALDARDPEGTRCRSVEKYIQEEAPHKHLIFVLNKCDLVPTGVAVSLYIFHIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEG7</accession>
    <name>D4DEG7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020363.1">
        <property type="nucleotide sequence ID" value="XM_003020317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEG7"/>
    <dbReference type="ESTHER" id="artbc-d4an28">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="9584113"/>
    <dbReference type="KEGG" id="tve:TRV_05534"/>
    <dbReference type="HOGENOM" id="CLU_046024_0_0_1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="57916" checksum="78E15C24B31EFBE9" modified="2010-05-18" version="1">MPEANGASMDHPVLKMAVAIFSFVYGIFTVVLYGVTAILSGVPFRQTTEKERLEFQLASDRFWNLSKNWKNFSHRFMTLRNGFKVHYLANVSPDETVASNTGNLPLVIFLHGFPDSWAIWRHILSSSSIGEKSVMIAPDLPGYGGTDSLDVYGPTEILETLTEFIVTVRDQYKVYDGDGQTKRRVIIVAHDWGAILAFRLAAEAPQLADRFIISNGVLVCSSISFFCSFLLPSFFFFSFLPANMRYCPWQKPGLMQDNIYLSIESANKMFKTFLREPWRSRHVLCKSIKALAPVLRQLKKSQYIFVFHLPVPLVRYVGHGGNYSFLRAIHELAAGKTAEFTVRDAQEAMASTLGPSIEELKTKTAEGEAYSESVRIRAEQGNFKDTTSYYRHGAVSGPWHKSLETISALHSICPDERRRTSCGTGVFDPAPGALKANATMLWGMKDPAIDNHLALDGIADRLIQGSQVIVLPRSGHFTPMEVEGRGALEETVLWAVKGETGDVGQAVLSVYPEARVVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEQ6</accession>
    <name>D4DEQ6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000305">
        <property type="protein sequence ID" value="EFE39673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020291.1">
        <property type="nucleotide sequence ID" value="XM_003020245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEQ6"/>
    <dbReference type="GeneID" id="9584030"/>
    <dbReference type="KEGG" id="tve:TRV_05645"/>
    <dbReference type="HOGENOM" id="CLU_1367119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="200" mass="23786" checksum="4166423D42B5C5C5" modified="2010-05-18" version="1">MTRITPYEAEDEEIILRAPEKPSTLSSLAKCYLSDIKRRQNRQQAKQARRYDSKARPQTLPETQRRRNGERPVNAREKKKAKKRDERQAEMSFQRFLLLVTDEEEKKKKKKKKQTSWSVCCLTKEKEEEEEEEEEENTKHNRNNCRRRRRLLHLLLACYLSPGFASVVPRESSSKQQQQPAHGKRLSIRRLAMTSEHHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEV6</accession>
    <name>D4DEV6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major allergen and cytotoxin AspF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000312">
        <property type="protein sequence ID" value="EFE39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020232.1">
        <property type="nucleotide sequence ID" value="XM_003020186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEV6"/>
    <dbReference type="GeneID" id="9582776"/>
    <dbReference type="KEGG" id="tve:TRV_05696"/>
    <dbReference type="HOGENOM" id="CLU_2348203_0_0_1"/>
    <dbReference type="OrthoDB" id="4998592at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056217" evidence="2">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="97" mass="10246" checksum="BE05AF1226B6FA5A" modified="2010-05-18" version="1">MVSFKAILTLSLIGAAFATPIEQRAAEPVEDSGAVANSPEGSGMDLGGTDPTADAIEERGLLVRIILRQLLNNKQSGLTIISSTSNAITWLSRPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEX7</accession>
    <name>D4DEX7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000314">
        <property type="protein sequence ID" value="EFE39595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020213.1">
        <property type="nucleotide sequence ID" value="XM_003020167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEX7"/>
    <dbReference type="GeneID" id="9583982"/>
    <dbReference type="KEGG" id="tve:TRV_05718"/>
    <dbReference type="HOGENOM" id="CLU_013869_1_1_1"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="74698" checksum="B25B2B65C80A6E5B" modified="2010-05-18" version="1">MNQDEGGVGPSSLKGFYSYKNTFGADSVWLDIPKEVVFVDNSDPYADELEEQFTADTPLDTHGEPAWSHGGGYLPPFTEAQTHGLDALSAAATAENHPIYQSVADHIAENSNSHTRLETTEHPEATISSSSPTIARIPTEASPGSLSLPLSSPNNNVGFVLNAPPNGMPQPIDPGLHSPENQRATSSVSQGLTQVMRVTSLVETEHEAAFFLRHFSEGPGRCPLLKYAACAYSAKQIGRIKGTNAVTGGSCLRQAMMEIWPDTERVDWNYYGVKYYEKAIQLLMEELQHNGNFSPLSGSQTSGNLQAEDPGGLENTSSKRRKVSIAEVQLSSPHSDDVLAAISIIFAYEFLDNTSPVWDRHFSGVQSLLDIMKAGIVPSEKQNSSGNLNVATSKLPRFSKVGKAIFWNFARQDYLSAFINETLTRLVTSDLTLWTEAGLILNDAGFFQQESATEHNESTKEDIISNTLIWILSKIVDFIAVGDSRNHGESFTGASQNTLLDRWNRLQAELDTWFHALPDTFKPCARIDSPPGPHSSQDVCPFQEIWYSIPMCASAMQHYHMARILLLINKPHESTARRSTVTDRLNSYRSIEKEIQNHSREICGISASRLEASARIHSIQPLFVSGQCLTGELERKAILQLLCRIEADLGWATKYRVQQLLAEWNWDETVLDSLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF87</accession>
    <name>D4DF87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020060.1">
        <property type="nucleotide sequence ID" value="XM_003020014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF87"/>
    <dbReference type="GeneID" id="9583824"/>
    <dbReference type="KEGG" id="tve:TRV_05833"/>
    <dbReference type="HOGENOM" id="CLU_024640_1_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58138" checksum="98D0732F21827F79" modified="2010-05-18" version="1">MHIRPKNIVISLVLAIPIFFLWATVRYDRIALSNLAHSFDQLSRSSLNVSPLTRFQPQLSSVEAVNELCKRGLMVPPPLSYSEWLHRKNFTRAYIRPNMVSSDAKFAPLETIKQPVLPDFMALDRGLTAPPEDKGESALTCPPVIDVDVAADSEVDDTAAILFGLATDVDRLRRLLPSLLFSYGSSKANILVLIPEGTKDIDIHETYFRNRGLNLTLKTSPLEFTARYFGLVEAFTEHIENNLPNVKWVSFVDDDTFFPSLATIGKRLATIDATKRHYIGSLSEADIQVKEFGPIAFGGAGVFVSKPLLETMHTVYQKCQDLGTQPGDQKVAHCIKKFGNTDLTLWDSLYQMGIRGEPDGLFESGRHFDSLHHWQSWYNKDVVKMSTIAAVAGRNSVLRRWRFDERITGKGQRTFWVLTNGYSMVKYTIDASANAESVGFDKVEKTWDGDDKVFEKRLGPLRPKDQPGVKKERWMLAEATIIGHNVHQLYSRELDETHSMIELIWLGTPDGSETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF97</accession>
    <name>D4DF97_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020070.1">
        <property type="nucleotide sequence ID" value="XM_003020024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF97"/>
    <dbReference type="GeneID" id="9583834"/>
    <dbReference type="KEGG" id="tve:TRV_05843"/>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25570" checksum="A40F46CF957D8125" modified="2010-05-18" version="1">MGFAINKVLTGYIIADLLFLLGGIILLLGSRLGEASLHHERNVENAMRSLLIPRCPIIPSLANAICVFAAFLCSIPVIVFPQNGIWLRLHGWLLVFSGIFTLSLGLSVWYEALRTRSTLQPMWSRETGDIQGLLQKKFDCCGFENSTSPLYHYDSTCMSDLLAAQKPGCIGPMSDYAFSFFGNISTATFGIVAIDAILLLCVAMLFKDRKDRTRYRLIDEKYELGMRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFH5</accession>
    <name>D4DFH5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="ACYE01000338">
        <property type="protein sequence ID" value="EFE39405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020029.1">
        <property type="nucleotide sequence ID" value="XM_003019983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFH5"/>
    <dbReference type="GeneID" id="9580198"/>
    <dbReference type="KEGG" id="tve:TRV_05925"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000045">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="254"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="300"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="371" mass="39405" checksum="31AA2A222F0B8032" modified="2010-05-18" version="1">MAPSIRVIGSLNVDMVSVTPRFPVPGETLTATSFTTSPGGKGANQAVACGRLSRSRTSSSSSPSGVLANVEMVGAVGRLDAHFGTLLQPTLANSGVSTDRVRRIDDEHTGVAVIIVDTSAAGENRILFSPNANYTGMKPTDEVISQSLSTPLPDLIVLQAEIPIDTVIGILRGVAAKKKLQESDVEVVFNPAPAPEGGLPDDVYAAVDHLIMNETECGLMAPEELRDSGLSQEEQRNKIAVHFHALGVRYVIVTLGAKGVWYSAAEPGKVAQQDAGTWIRSVNEVPASRVDKVVDTTAAGDTFVGGYCVQIAQWREQRRAAGKACSALTTDEWKDRYGIVTEEAVRCGTRASAQCVQRSGAMDSIPFRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFH8</accession>
    <name>D4DFH8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019960.1">
        <property type="nucleotide sequence ID" value="XM_003019914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFH8"/>
    <dbReference type="GeneID" id="9580188"/>
    <dbReference type="KEGG" id="tve:TRV_05928"/>
    <dbReference type="HOGENOM" id="CLU_080071_0_0_1"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="34337" checksum="1B7015709D44C9F1" modified="2010-05-18" version="1" fragment="single">MACDTVSRSCVNTASHNPHFPPAPFSAATISSRAHDITDPSSTLALRLLAPDSSILEDHRKHQNQNHSQRPTIGPPVGSAVMSHHYQHHDEDQEYTYGRNNQYNFSQPSFNQSYSNHQVLAPYNHHSTETASIAPSYSSQQAIYTQAPQHSSLITHSSSTGYQCHPQYMSQPRFPAPHRLFPMHEPFWEVEIEAQESCNEQTVLSEPVIPALEGFPDVREFDQLMKRFSSSSSSTPWKLIGLNSYVDDLSVKKQDKALIHSRRARNIKIVLTDPKDIAIESAQFRFWVKKMFTLVPKDNNIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH02</accession>
    <name>D4DH02_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000366">
        <property type="protein sequence ID" value="EFE38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019520.1">
        <property type="nucleotide sequence ID" value="XM_003019474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH02"/>
    <dbReference type="GeneID" id="9578209"/>
    <dbReference type="KEGG" id="tve:TRV_06457"/>
    <dbReference type="HOGENOM" id="CLU_011003_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="71565" checksum="B5C23920B620AA8D" modified="2010-05-18" version="1">MNPPRKRPWSVAELSSNPSNPPPPLEALHSAPNGSSASDTAMYRSPDSLSKTPNTPPVSFGIAPPESPQISVAVTSRKSTACPACRKQKDIVVEQARYDIYISTPASIYTELQSLMAALSLPPVSAVDELSMKEEDSKASQREQADEQPNTLEVAMEQDTLASAPMRSLYEVTKSSEVHEKTTQFSGLVMEPDFVSRGVITEAEAGQLTKTYLTRLDHFFYDHLQKYADISEVRKTSTLLALTLCTVAALHDPLGTDAYDKLSRELRSVTSSLMFRTHLGVEDIKALCMGSYWLGNLTWVLSGLVLRKAIGMQYHTAHMNQPQTDKEGFGKSQMWLLIFLANEQISILHGSPACGVEPGYINWKNHLASPFSGEIDLRLISHIDLLLLLGKVRQTYGVDAMKPIPLSLIPQLRDYLAQLDRWSQAWTGRLARNKWLGNFPSQAVKLHFRFAKFFICSHAFRGLNVEAAHVPLAPELQDIAGSAVATAISILELLIESDELRAYLVGIPHYFHTMFAFAAVFLLKVATRNRQHVHVDTQLVFRISRRVLEVFQHCPCAKQHLVHRIAQGLQEMIERCEGQIATESSGHPVNRVLNREPPIPASMPPPPTTSNPEIGSQDMLSWFNLENFDFLSMSPPTWNTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH37</accession>
    <name>D4DH37_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000370">
        <property type="protein sequence ID" value="EFE38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019477.1">
        <property type="nucleotide sequence ID" value="XM_003019431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH37"/>
    <dbReference type="GeneID" id="9577927"/>
    <dbReference type="KEGG" id="tve:TRV_06492"/>
    <dbReference type="HOGENOM" id="CLU_018248_0_0_1"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="614" mass="68234" checksum="6E0C869FDEA43FC3" modified="2010-05-18" version="1">MASQDIRSGARRSSRASGGRELKLPPSYTVDGRTYTAGPEMRPRSHTISAEASRIPLNPLSLPSSPSRQPVVTTIKPRSQTIYPTPSRDGGERYITPSSSHSRHRQASGPLGGEPDTIVPSGERELKYRNGYLTPAGNSGFPSPNRDSSYKDIDVHDSFSYTNAREQFYRDSDAIRESRRQVPAVRKARPLSLTGLEAYLPQVTRDPKAAGPPPSSRRFLAPEREDAPRNYREIKPRDLDADTARNNPTVPRASDNARQNSSLRNPVSLHQDRTTSPSPAPPAPRRSGYDNSVEKGYQIRRDANNNVIVDDKPETARRDRRLSVSGQTPNRDRGYSTGRAPDGMTGGGLATAGLASGYSNEPMDAHPRSEARSGRDRSDYSSRPEDKYKSSRNWPQDTNGGYYSDGARGNHQYKPSSSSRETERRPRAPSPVDSDSKRSINSSRPENYERAAQRESNSSSAKRSPPPASGTSPDTQAPRGILKQPTEKFPEEPHAVREGVAPLKDAPKKGVPAGARWTKIDRRLVSPSALEGRERFEERPDYVIVLRVLSREEIEEYALSSAKIRATRTRRISDRKSRDEDDTRARGRDSDSDDEDDHSSSQLRLEPPPRDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHD5</accession>
    <name>D4DHD5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000378">
        <property type="protein sequence ID" value="EFE38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019388.1">
        <property type="nucleotide sequence ID" value="XM_003019342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHD5"/>
    <dbReference type="GeneID" id="9580103"/>
    <dbReference type="KEGG" id="tve:TRV_06591"/>
    <dbReference type="HOGENOM" id="CLU_030115_0_0_1"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="526" mass="60847" checksum="37D60B47ED75511E" modified="2010-05-18" version="1">MDQLTSHILEKKVKEFIDSIEPSLVCELASSLHPEKKSCKIFSDPKKGSYNVCFPIVFTEQIPDAADSASTQETTERWMIRIPLLPRLAFPEEKLRSEIATMKFIAEKTTIPIPRLYHYSINRDNLLNLPFMAVEYIMGNTLHGRISKLPKEQELYLYGQLADIYLQLHRHQFDRIGALTLDSNDENWVFEHNRPLTIELNDQELSGLKSSEIIPAHQTYSSTIDYVYTVMKLVFNDFYHSRDSVFNETDARNYLYGIFASQGIVMEWVDERDNHGPFLLMHGDLRPPNIFVDDDLNIISVIDWEWSHTVPSQMFIPPSWICGQELPAATTRPYHLVLDVCVSQFQRAARDREDQHYNPDKKLKLCLPLVKLWNRHLKSEKLFIAYALLKPRYLGNVYWNLLDNIYHGTDSGERVDSFYKLKVRKRQEKELQRVLSDLEAYKKELALAGLEPTQPAAPLVLKPAEGKDSNTLSKSGEDADSAIYRIWKKLDFKNIKNTLSPLHCWVPCSLVGVSIIVCCIIAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHP4</accession>
    <name>D4DHP4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000382">
        <property type="protein sequence ID" value="EFE38651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019296.1">
        <property type="nucleotide sequence ID" value="XM_003019250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHP4"/>
    <dbReference type="GeneID" id="9577618"/>
    <dbReference type="KEGG" id="tve:TRV_06700"/>
    <dbReference type="HOGENOM" id="CLU_1111147_0_0_1"/>
    <dbReference type="OrthoDB" id="10524682at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="245" mass="27207" checksum="5E013AC9A8AD7F96" modified="2010-05-18" version="1">MKSPWTEQPAVFHLFLFSSLFSFALLGFFFFFSFLDGCLTKVTPARKGEKRLLRRTLIVGSASSVPLFLIVAIITLQLYFSFPGFISFFQLRQLLKQAIPDSYQSNLSINIFVSSFDRQEPSFARRVISINQYQLGRIPSIYQISLANTTATAKKYTSTMASTMTRPAHSSLPHTMHPFPSTGADSTSPSTKQLSVSTLSLDIQRAMQSSSSQPKYISAGNNDFEHPPPPPPSPVGFPSGSTSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV1</accession>
    <name>D4DHV1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019209.1">
        <property type="nucleotide sequence ID" value="XM_003019163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV1"/>
    <dbReference type="GeneID" id="9577206"/>
    <dbReference type="KEGG" id="tve:TRV_06758"/>
    <dbReference type="HOGENOM" id="CLU_015910_2_0_1"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="651" mass="73782" checksum="409C863BF7162BBB" modified="2010-05-18" version="1">MTERGIEIVYGRWLIEGAPRVLLIDTGAGYKYLDEWKGDLWNAAGIPSPSADSETNEAIAFGYLVAWFLGELIFRQYICRDTERAVIAHFHEWLAGVALPLTKKRRMDVTTIFTTHATLLGRYLCAGSVDFYNNLKNFDVDAEAGKRGIYHRYCIERAAAHSADVFTTVSHITAYESEHLLKRKPDGVLPNGLNVKKFSAVHEFQNLHSHSKDKINDFVRGHFYGHNDFDLENTLYFFTSGRYEYRNKGVDMFIESLARLNHRLKVSGSKTTVVAFIIMPSQTSSLTVEALKGQAVVKSLRDTLESVEKSIGKRLFERCLGWKEGDNMPDEKDLMTNQDRVLIRRRLFAMKRHNLPPIVTHNMINDSEDPILNQLRRVQLFNYPTDRVKVVFHPEFLNSANPVLPLDYDDFVRGTNLGVFPSYYEPWGYTPAECTVMGIPSITTNLAGFGCYMEELIENSADYGIYVVDRRLKGVDDSVNQLTSYMFDFCQKSRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRAYPTSFDAADDFHEAIGHTEQKISRPLSVPGSPRDRTGTMTPGDFASIQEGREGLDTEDYISYKPPTSANGVNANTIPRAGSDDEEEDSIPVPIRPKRQSISLKLGPAPNGHGVGSETKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHV4</accession>
    <name>D4DHV4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019212.1">
        <property type="nucleotide sequence ID" value="XM_003019166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHV4"/>
    <dbReference type="GeneID" id="9577209"/>
    <dbReference type="KEGG" id="tve:TRV_06761"/>
    <dbReference type="HOGENOM" id="CLU_022749_0_0_1"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="567" mass="61225" checksum="588E92641EF5F0DE" modified="2010-05-18" version="1">MAAEDSMLARADALLEALFSDWNIYSTLLATVLVSYIGYTLFFTPDPDAHPYVLARQGVVAPVRQRGESASVRAMDVPHGYPLKAGLGVRDPDTPRWTAGRRGDLRDIWKAVVRGELNSDGTPSGKKGSIFTVFGNTAQERSVDDISREIKIIGQYISDTKAQRVAICLTDSVEMLATIFASAFYGFPTVIIPHNLPPQTLAGYLQETKADVLIAEAGAVEVTTLLKMCPALRHGIWVAQEGSRHMDWNEVPEGAGSKIEVSTWHELVNEKEGSVSPEVPEWDVKSPTPSLTTLCPSKKGLGSFIEYTSENIISGVAALGSSLPRNEQLKSSDLVLSIDSLAHSYTLCFVLAALYSNASIAFNSVAGEIVDFALATTGVSPTIIIASSHTMSDYHAQYMGPQLNPLVKLGRFFQTRALDSGRMPSSNILSALGGSGPVSEQTLKNLRLILVSHRAEGDRNNQLTSDQLTDFRIMTGARLAYALTTGKVAGAVCQTNPYDYRGQRGFSHFGPPLNSVEVKLVDYDEKSGNEKAIEGKIHISGPAVVSGECKLEADGLFQEDNTLVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIC5</accession>
    <name>D4DIC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000404">
        <property type="protein sequence ID" value="EFE38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019032.1">
        <property type="nucleotide sequence ID" value="XM_003018986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIC5"/>
    <dbReference type="GeneID" id="9582440"/>
    <dbReference type="KEGG" id="tve:TRV_06933"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="170"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="620" mass="66842" checksum="6F75E8B26688CBD8" modified="2010-05-18" version="1">MVFGLFQVQSLSLAHKGRQTLRQTPADPGLFSPGDRVIPADSLSLPLAVSISARSRAFRRGLLSLSNSLYIAVFGCTSPTLVGFLPPLICPWSKSSHTHSATMADAFKARSLKRKNVKGLALNAAASKPGLKPSDGDAQIPGAIGNVDSNRTDTLEIGLEFKLDLRSEDLIVLKELGAGNGGTVSKVMHASTKVVMARKIIRVDAKEKVRKQILRELQVGHDCNSAQIVTFYGAFQNEARDIVLCMEYMDCGSLDHISKNFGPVRVDVLGKITESIFAGLVYLYEAHRIMHRDIKPSNVLVNSRGSIKLCDFGVATETVNSIADTFVGTSTYMAPERIQGGAYSVRSDVWSAGLTVMELAVGRFPFDTSDTSAGDRASAGPMGILDLLQQIVHEPAPKLPKSDAFPKILDDFVAKCLLKKPEERPTPRQLYDHDAFILAAKRTPVNLREWAISMMEQHNRKSYLAPPAPKAITRDGGSGESPSSSGPHTPDETPRQATSGEIPLNIAGDITPRSRPQATYGIEHSPSMGFEKLSLNTNQGQNYSSGSVPRSSRSPYPHSATSTSQGPFAAPRPAPSPVYHTTRNGSQSAGLPHLAGPPPKGPLPIPPTSDSWRSQSQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIF1</accession>
    <name>D4DIF1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase, putative subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018948.1">
        <property type="nucleotide sequence ID" value="XM_003018902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIF1"/>
    <dbReference type="GeneID" id="9582106"/>
    <dbReference type="KEGG" id="tve:TRV_06959"/>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056295" evidence="2">
        <location>
            <begin position="25"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="289"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="796" mass="88009" checksum="006392E885645912" modified="2010-05-18" version="1">MVSAAWLRYPSLLTLGVLVCRVTAQYEGDVLRYVDQLVGTANGGHAFPGASLPYGMAKAVADVDGSENYGGFTTEGSNVTGFSHMHDSGTGGKPSMGNFPLVPQICQDDDINKCKFSKEDRAVHYIADSVKARPGYFAIKLNNGIAAEMTVTEHAALYHFDFPHNNAESNGTLPVILVDLTDIQDSRQNAAISLDEDTLRVKANGTFLPSFGIGTYNSFVCVDFSGAEAKDTGIYISNRAGTLPKAISVGRGFNLFYIQAGTYLQFRASSNGPTRVSARVGLSFINEDQACKNAEKEIPGSNWDFEKVRTDAESAWKEKLGLISLKSGGVSDIFQRTFWSAIYRSMISPQDYTGENPLWQSKEPYFDSFYCLWDSFRSQIPLLAIIDPTTLAKMIRSLLDTYKHQGWLPDCRMSLCKGFTQSGSNADVVIADAYVKSISDNIDWDLAYEAVVKDAEVEPSDWSVEGRGGLMSWKSVGYIPAQDYDYLGTGITTRSISRTVEYSYNDYCVGVLGKGLGKEHEKYFQRSGNWQNLFKADQTSFIDGKDTGFVGFFQPRYYNGTWGYQDPILCSNIAAFCSLTSNSQETYESGIWENQFFVPHDMSTLINLLGGRSKFVARLDYLHDSNILYIGNEPSFLATFLYHYAGRPALSAKRAHTYIPSRFNDTTTGVPGNDDSGAMGSFTVFAMMGLFPNPGQNVYFIMPPFFEAVSIKNPVTGKIATVRNVNFDSKYENVYIQRATLNGKEYTRNWIGHEFFLNGGTLELTLGKEESSWGTGQNDVPPSLGAGIKRDGLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIN1</accession>
    <name>D4DIN1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018909.1">
        <property type="nucleotide sequence ID" value="XM_003018863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIN1"/>
    <dbReference type="GeneID" id="9582097"/>
    <dbReference type="KEGG" id="tve:TRV_07041"/>
    <dbReference type="HOGENOM" id="CLU_018583_0_0_1"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="73657" checksum="3D846AB592B98ED9" modified="2010-05-18" version="1" fragment="single">TETMASSKHLFLSDEELGKKYDDHNRRDSIYGLSLGSFWRRFPRRRRIALVFFVAFVVFIFCKHIPTRVEDVGQRSQFLDDPWLRPSRETNFGSEPAEIDSTPDENGIKYYRGPIEFESLFESLYSTRSLSYDAGQESVIFATGQLKSLGDMLPVACDMAARKRSSVHLAIMGRDEIPLADIQRANGFREEDCPVTWHELSVKAALVHMYRILAPRVFITRDIEFKEAFFIDAIELRAFQLGITHISLPSPLSNFKWIADLDAFSLEAWNDVHTEILINVQPNSSGGPRKLLRSLQEADYFGPAPGLTIELPVDADPTLLYFLKNFRWPPKTAHRQFTLRRRISPSVLTSQEAAVRTVDSFYPKNPNLSHVVLVSPDTELAPSFFHFLKYSLLKYKYGDSENSPGHLFGVSLELPSSRPTDGKPFSVPMAISSPNLSKGRSAEIPTLLWQIPDNNAVLYFGDMWAEFQSFLSHRLSTSIQKKGKDVHKVIMKSYPSWMDYMLEFMRARGYYLVYPAFAVQDDLAIATVHNELHRPPEEYDDPTQRQVKPNFEEKDLAHSPSTLSTLLDVYPGMLPDIRELPVLPYTGELTHDDKSTNEQVSFLQTFRKEIGGCTNSDEKPESVPLKADDLFCIEEEPISIEGVEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJF2</accession>
    <name>D4DJF2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE37985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018630.1">
        <property type="nucleotide sequence ID" value="XM_003018584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJF2"/>
    <dbReference type="GeneID" id="9580781"/>
    <dbReference type="KEGG" id="tve:TRV_07318"/>
    <dbReference type="HOGENOM" id="CLU_032013_0_1_1"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44310" checksum="09D8367D37B168DC" modified="2010-05-18" version="1">MGLNEIRTAMRVDRRKPAAEQPGVHVIPACGSIKNGETVKIECLDWTGGQIKNNDCADDVRDVDLTHVHYLSGPFDVETAEPGDVLVVEIQDVQPFQDEPWGFTGIFAANNGGGFLSEFYPQAAKAIWDFEGIFCSSRHIPGVRFAGLIHPGILGCAPSAEVLAEWNRREGQLMAENVGSEVAKPPEVKNAHAGGATGELKAKIQKEGARTVPGRPENGGNCDIKNLSRGSKVYLPVHVKGAKFSVGDLHFSQGDGEISFCGAIEMAGIITVKLSVIKNGMVQMAMKSPIFIPGPVEPQFGPGRYLTFEGFSVDHNGKQHHLDATVAYRETCRRVIEYLRRFGYSDEQVYLLLSCAPVQGHIAGLVDIPNACTTMGVPMDIFDFDIRPESVPEKRDLGSCAFTSDRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJK3</accession>
    <name>D4DJK3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018611.1">
        <property type="nucleotide sequence ID" value="XM_003018565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJK3"/>
    <dbReference type="GeneID" id="9584540"/>
    <dbReference type="KEGG" id="tve:TRV_07371"/>
    <dbReference type="HOGENOM" id="CLU_692966_0_0_1"/>
    <dbReference type="OrthoDB" id="4174276at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055927" evidence="2">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="362" mass="36464" checksum="E3CB2F868E75D1A1" modified="2010-05-18" version="1">MRFQTLFFLSFIGLAASAAIDGLLGSLGGLGGALGSGQQAGAGNGAAAGAGALQEMDKDENPSPTAMANETGAASQETGASNSTATATGENQAESPAPTTESSPMPNSPEASQSAQGAMPSMSPSGNRDDGTQSMTQEQPQTMGGKPKQTMGDQPKQTMGDQPKLTMGDQPKQTMSGDQNKPQTMGGQSTQHESMVKQSKQSESNGTETTTMPESEGESAPMPTTSAEPVANGSRPQASDMSGRRPRPSAPQTGKMPAKQSMTPVATATPTATASAVKPTATSPAPSVMDLIADDDQEKQIEGTAKAPLKNSTKSPPSASAASEQPSSASSSPPSQADTQAKPSSSSPSSSSSEVNSFFNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJY9</accession>
    <name>D4DJY9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_07498</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018484.1">
        <property type="nucleotide sequence ID" value="XM_003018438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJY9"/>
    <dbReference type="GeneID" id="9584413"/>
    <dbReference type="KEGG" id="tve:TRV_07498"/>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="154"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="516"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE37839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="67467" checksum="50FB88E765D2EDFC" modified="2010-05-18" version="1">MSGYQDMYNSSASRSPGSHRHPPQQLRRQPSRQFDAYGPMSSALYEEPPLGRYDTNPLDRLNATMPSGSYPYDISGSQTWNANCVGLGGLAVNSATATSRMRNVRSRTALPTQTWLDQQNSLPNSFSLAPGQHQPSPQIRAENPHDAEDELIPTAIVIKNIPFAVKKEQLIQLMTEMNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIELLNHFELQGRKLRVEYKKMLPAQERERIEREKRERRGQLEEQHRPMATSQLQHQTSMSSLASHLPTTSPSPVSQRAGKLEVDMNDAQTLQYYSQLLLFKQDLSKEALIFGTNLTPAQRRIVHTISHNMGLAHTSRGTGDQRQVHVYRAGPGANVSPPVPAMPATVTSDAARRGLSRAATIDFGESRHEQQAYGSSMRQSSFLNVLDSPGPGGYANAQNLRAAKSFADLRSFTPSPVPSSASFPAALQTNGARFQQQQQQQQQAYDAGTSGASNTPTLTPTPSGSSLGIQRVDDSLLVNSLGGLSLGTSVTGPSGSPRRTRGIWDASDLPTTTAGSNNGSGSSAGAIGSNRSIGLGFDSGNQNQERVPVRQPRGPAPERGPGFRRQNSHQQRGSDELRSNPGVEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK20</accession>
    <name>D4DK20_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000450">
        <property type="protein sequence ID" value="EFE37796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018441.1">
        <property type="nucleotide sequence ID" value="XM_003018395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK20"/>
    <dbReference type="GeneID" id="9584371"/>
    <dbReference type="KEGG" id="tve:TRV_07541"/>
    <dbReference type="HOGENOM" id="CLU_027146_1_0_1"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="549" mass="63007" checksum="78F6F0AA8749BDB9" modified="2010-05-18" version="1">MSDKPEKPNMPEITQSVEAPEDTNQSDPESEPYSDLDGRPYSYRQCVAALQAEGVPKDLSSKTARWCVVRGIRTSYEYATSPGVSRICDDMTIPQFARARNARLIMSNVIPEGMEDPRVQPYCIWIPDCASADTYRKLVHRYPAMLYQVGRACGAAGYADLYKELVKDFKLLPEVSIAEEARESGTNGGREIYRLILDSPIKYAVLDDNTRGINVDNPQFPAYLNGNTAVRWKVEPRGDLLEDGEYDQGDQDIEEDNRLDVAAAYLDDQYKCLSAEEAKWFYQPLPADIPTVKKELLRDMAAYEGNIDRYHRLMDPQEMTHSEVTCVTRGIYHNTMFARWWMDQLEMNTSRIPKQDVWRIRSAINARRIMINDISGFHDEMEGKPYLIWWPLKPHRKCLEALAKKCPSMQEQIAIACIFCDYEDIYQSINPVPHWRIRLAATKNANPFYLADIDKRALEQGIDVTERPGEQDGRKDSLSSDIEPTSMWVESPINESTMVSRLPDFHPYFGSRVEPGIIERYVFKSPEVLQKIEALRTRCFGDDTDLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKB7</accession>
    <name>D4DKB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000463">
        <property type="protein sequence ID" value="EFE37704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018349.1">
        <property type="nucleotide sequence ID" value="XM_003018303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKB7"/>
    <dbReference type="GeneID" id="9584277"/>
    <dbReference type="KEGG" id="tve:TRV_07639"/>
    <dbReference type="HOGENOM" id="CLU_1229667_0_0_1"/>
    <dbReference type="OrthoDB" id="4173794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="225" mass="24141" checksum="BE8966D1D0240A25" modified="2010-05-18" version="1">MAPTGQAYSSYQPQSMYSQPPPTTYSYYPTQSYAAQTGMPYPAPQSGPAQSYYPHVNQGYYTSQSQQPVVHHLPPAPVGMFTRNLIGSLSASAFKLSDPAGKLGIWFILQDLSVRTEGMFRLKMNFVNVGTPQQALSRSGNTSSSTPVLNHGSAPVLASVYSDVLQVFSAKKFPGVIESTPLSKCFAIQGIKIPIRKDGVKGGRGGGAAMMLKGDDGDGDEQYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKN1</accession>
    <name>D4DKN1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Membrane bound C2 domain protein (Vp115)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07753</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000475">
        <property type="protein sequence ID" value="EFE37587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018232.1">
        <property type="nucleotide sequence ID" value="XM_003018186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579608"/>
    <dbReference type="KEGG" id="tve:TRV_07753"/>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="223"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="423"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="567"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="693"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="875"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1481" mass="161482" checksum="2E904FC7AFC0A248" modified="2010-05-18" version="1">MATQAESPATDAARPAPEAIEQKLVDESKKAGVPAFQFDPDAAPEKKAEQAKMAIPAGFQKNGTNGTNGSQAAVNGKKADAVALATDMGATNGTKKPAEMDKADEADKPKMEVKELTEEEKFAPGRTGWAPRFSAPAAEDGAGEEPGLPPTLLEGKLEDKFFGVIIFACLASWIIALFGGGLGWVFLVMAACGTYYRTSVRRVRRNFRDDITRELAKNKLETDTETLEWINSFLAKFWPIYAPNLAHSIICSVDQVLSTSTPAFLDSLRLKTFTLGSKPPRLEHVKTYPKTEPDIVLMDWKFSFTPAEKMDLTARQIKDKINPKVVLEVRVGKGIVSKGLDVIVEDFAFSGLMRVKVKLQIQFPHVERIDISFLGKPEIDYVCKPIGGETLGFDINFIPGLETFITEQIHGNLAPMMYDPNVFPVEIAKMLAGNPVDQAIGVLAVTIHGANGLKKADQFSGTPDPYTLVSINSRTELGRTKTVSDTSNPKWNETLYVIITSFTDALTLQVFDWNEFRKDVELGTATFSLESLETEEVHENLNLDIMQNGRNRGVMQADVRFFPVLTSKKTDGGAIEPPPELNTGIAKFTVEQAKDLDGSKSFIGQLNPYAVLLLNGKEVHITKKLKRTNNPIFPDPSKEILITDRKTARLGMMIKDDRDLATDPILGKQQIKLNDMLKMMDKGKEWFDLAGAKTGRVKMRLEWKPVALKGVVGSGGYINPIGVMRLHIKNAKDLRNVETMGKSDPYLRVMKSGMEVRRTVTWLNNLNPEWDEVLYVPVNSAREKLVLEVMDDESIGKDRPLGLVELNVGEYIKEGEDGEYEVHDEKRDLSTPLKLDGRSNQKGVLNYTVAFYPTLQVVDPDEEADELEAQKELAAAAAEEEGKPTDADTAVNAEATTNGDARPSTDGLVSGEKAEKEVPKIHLTAQDVHKYESGLIVFKLEEGDFSSTGTQLEVLMDDNLYPTYTSPKIQSKHMVFGDVGDAFVPEMEFSKITLRLVDKSDRHNEDSDDHSIAKLSGPTLATLQQCLYKPTELVLRGSDGINSKVTVSLKYLPVKMKLDPSESINNMGNLRVDVLDAADLPSADRNGYSDPYCKFKLGDKEVFKTKVQKKTLHPAWNEFFETPIKSRIAANFRADVYDWDFGDKADYLGGTTIDLTNLDPFQAQEISLPLDGKSGAIRLKLLFKPAYVTRSRQGSSTFSGTFAAPGKIVGAPVKGVTMLGGGVVKGASFLKHGFKRSSRAQVETEAEPEAAAAATATNGTHGHTPSVEVSAPGTPQRAGALADSPSGSPVMSHSRSRSSASQAGLGVSSIKGETGAANITIVSATGYPRSTNVRVVVKQQTSKGMKEIHKSKAHKAHGSSSEAESVVQFDPGHETIKINSVTADAQFQLQVKDHAVFGSDDILGEALFFLDDQGSNAGKERNVKVGNGFVTIKTVFTSSESSSLRPGTSHSNTGPEESTADSPKPRRSFLSKRSVSGVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKS2</accession>
    <name>D4DKS2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000480">
        <property type="protein sequence ID" value="EFE37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018193.1">
        <property type="nucleotide sequence ID" value="XM_003018147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKS2"/>
    <dbReference type="GeneID" id="9579563"/>
    <dbReference type="KEGG" id="tve:TRV_07796"/>
    <dbReference type="HOGENOM" id="CLU_031977_1_0_1"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="245" mass="27799" checksum="1BC3C0A78E9308D6" modified="2010-05-18" version="1">MSAQLTESLPFTASSDVRSIHRTLHLLYHHNKNQHRCTKWWKWLNMLRRWTLNLACEIEKIEKFEDVLGADGSDEHPFSPVWKIMRYLHDELIPRCYRAFSTVVADIQFCSLGITLLATLAEVFKVVQINKGELSNIARELGDEKTLETIPRSASNVTVAEDFGEVIRRSEVGSHIKTTVDSTVSTDGEAGTKKNRKLCLDESMKRKVDYDTAMTASLGVADSSKEKKKKKKRKVNAIDDIFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKV3</accession>
    <name>D4DKV3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000484">
        <property type="protein sequence ID" value="EFE37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018131.1">
        <property type="nucleotide sequence ID" value="XM_003018085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKV3"/>
    <dbReference type="GeneID" id="9579340"/>
    <dbReference type="KEGG" id="tve:TRV_07827"/>
    <dbReference type="HOGENOM" id="CLU_010480_0_1_1"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="921" mass="100620" checksum="2A37DE3F4E35C4C7" modified="2010-05-18" version="1">MSSRPGIGKRFSHDRFTILPDSDPNSNGNPNGSGMSKDATIDIPLTAVPSVSQTGARKPEDGEHYFEKNHDGGGDAGGEGAERQIGGRRRAHGHHHYGDRSATSDEDGTITRMGRFYNKILNFSVVTRYFIYVLPVALLFAVPIIVGAVAAPTASIGGVRIVWFFAWVEIVWLSLWVSKAVAHYVPFVFQFLCGIVSSGTRKYALILRALEIPFSLVGWAITSLATFIPVMTRNPDNIKDPRIQPWQTVVNNILFACFISSLILAAEKVLVQLISISYHRKQFDSKIQESKRNVHLISMLYAASRKMFPEYCKEFEMEDYIINDSIMGITGKKKGHGRSGSASPMRLIQNVGQNVGRVGDKITAAFGHVAQEITGKQVFNSTSAHSIVILALEKRKSSEALARRLWMSFVLQGRDALYLDDLYDVFGPDHRAEAEECMAALDRDDNGDISLDEMILTVTEFGKARQSMSKSMHDVDQAINVLDNLLLAVVFILVVLVFVAFLNKGFGTTLAAGATALLSLSFVFAATAQEVLGSCIYLFVKHPYDVGDRVHINDNELMVEHISLLFTVFRNIQHHKTIQVPNIVLNTQWIENVTRSKAMREQITLTCDFGTSFGDIQLLKREMQAFVRAKDNARDFGPDVDIEVSGLGEMNKLELKVEIHHKSNWHNEVVRATRRSKFLCALVLAIKKIPIYGPGGGDAALGDISKPSYSVSISHEQAQHSKDEYAANKEAKRMIPTDQMDEALSADPAPLSPRPGAGTGAAAAAAAATSASGLTYRGSTASNSTSNVHSPHNPEAAFASALNSRPPMESTPSSANVTQEHLIRGPSTGHRRLSQNPNQNPSGRQGMSPNTPATEYQQYDYDNSNNPFRAASPPAQMYGQPGPSSQSPTPQGSVHPATIIARGQGQGQQDQAPLGQGPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL33</accession>
    <name>D4DL33_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018071.1">
        <property type="nucleotide sequence ID" value="XM_003018025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL33"/>
    <dbReference type="GeneID" id="9579279"/>
    <dbReference type="KEGG" id="tve:TRV_07907"/>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="839" mass="90955" checksum="47DAB08D803B4596" modified="2010-05-18" version="1">MAWQPQSAMAGNGGMGGGSMDASNGGGQPQGTEYTLQGVMRFLQTEWHRHERDRNAWEIERAEMKSRIGRLEGDARTSKRMHESLGKHVRILEVALKKEREKSSKLAAGETIEPSVDPKEVAKKSLKALEKKQPKPSSGLDNYADDEESNSPDAQHENERDKSRLYLGKCTQEVAYHIIPRSHPPPEINEQDLLNHDYQQHHMQRQPLDSSYIQEHQRQQQQSVPQQKQQLVPAQPQLNHVSMVREPEGSQMMMPTYNENGAQGSAQREFLDRRPQEPQRANETTQEERNANYEFPSKSEEPSQTESKSPEALSGKEDFGKPPPTNDIIVDEADGWNFDEAPSTEPTPAPVTRRPDTDAFPSANFIPPKSPTRGRGSRRKSSGGRRRSDGNPDVRELSGSVGPKADTTNFKVRFALRGHLDVVRSVIFTGGGSPSEPEICTCGDDGTVKRWIIPATYGVFGSNVAAPGSDLDVTSYFTHRGHNGSVTTLAACPPSQNFSSGGRATGDGWVFSGGQDGCVKVWERGRVDPKATLDGHKDAVWTVCVLPGTSKSVFGDQCNTNGGPDRVLLASGAADGRILIWAISAPPQLSSPQTSSRRSAGGSRRANSISSGSNFPTSPQPSTASSTAFNYTLVHQIVRNDIAPTCISPLSLAGVNFVVSYADASILVYDTRTGEEIVGMASLETYDGTRATGVNAVVASTIGFDGTANLDPNRALSEEESVVHGATGTSGGVEGVVISGYEDRYIRFFDANSGQCTYTMLAHPAAISSLSQSPDGRELVSAGHDASLRFWSLEKRSCTQEITSHRLMRGEGVCSVVWSQDGRWVASGGGDGVVKVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL46</accession>
    <name>D4DL46_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L23/L25 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000491">
        <property type="protein sequence ID" value="EFE37439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018084.1">
        <property type="nucleotide sequence ID" value="XM_003018038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL46"/>
    <dbReference type="GeneID" id="9579293"/>
    <dbReference type="KEGG" id="tve:TRV_07920"/>
    <dbReference type="HOGENOM" id="CLU_037562_0_1_1"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14280" checksum="2044D361E062D6CE" modified="2010-05-18" version="1">MAPKDTKKATKASSKAGAASKAVMKGLSRSPKYPRKSIPHAPRMDHHQVIVHPLNTESAMKKIEENNTLVFIADVKANKRQIKLALKKLYDIDTVKLNTLIRPDGSKKVFARLTPDIDALDIAATKLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLG5</accession>
    <name>D4DLG5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000505">
        <property type="protein sequence ID" value="EFE37301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017946.1">
        <property type="nucleotide sequence ID" value="XM_003017900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLG5"/>
    <dbReference type="GeneID" id="9579824"/>
    <dbReference type="KEGG" id="tve:TRV_08039"/>
    <dbReference type="HOGENOM" id="CLU_036517_1_1_1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="363" mass="42534" checksum="F0AC2837FA57C2E6" modified="2010-05-18" version="1">MEYQIIVYLSKFFTFTGLADDEEKVARGPSAPVMCEGEFESMKAINEVSPSLAPKPWARGKYKNEDSYFMLTDFRDVGKQPPDPVKFTARLADMHMRSVSPTGKFGFHTTTCHGTITQVTDIWEESWAVLYRKQLAHMFAMDLEKHGSWPEFEQLCDLILEKVIPRLLEPLQSEGRSIKPCLLHGDCWDENTATDMKTTEPFIFDAGSFYGHNEYDTGNWRAPRHRLSGKLYVKNYKRNFFPSEPKEDWDGRNLLYSLRFNIGTSILIPGCNQREIVFEDMKELCRRYCPEDSPTLIQRARNPGGTEEEEEEEEEEEEEEEEEEEEEEERRRGERKEAEDEEEEIEEEEEEEEEEEKEKSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLJ1</accession>
    <name>D4DLJ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_08065</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017899.1">
        <property type="nucleotide sequence ID" value="XM_003017853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLJ1"/>
    <dbReference type="GeneID" id="9583794"/>
    <dbReference type="KEGG" id="tve:TRV_08065"/>
    <dbReference type="HOGENOM" id="CLU_027506_1_1_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055964" description="chitinase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE37254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="40731" checksum="47C0EB8CF811F75F" modified="2010-05-18" version="1">MMASRRISVLSSLGLFACLLSPVVAQTFTYCNPLEKDDCPNAPALGQNYTTYLNSSLNPDVWNATSGIVEISDAGSNFTIHKALDSPTIQSFFYIFFGTVEVHMKAATGRGVVSSIVIQSEVLDEIDWEWVGSEPDKVQTNYFGKGNTTSYDRGKTFDIKGAMDDFHNYTVNWTPEKIEWYIDTVLVRTLKYEEALGGKNFPQTPSTVRLGIWPGGDPQNKKGVIEWAGGEIDYEKTPYIMSVKELKVVDAHKGKEYSYSDRSGDWQSIKVIDGVSDIANEINKPPPKSLAQRWRELPAAAKIAIFASIGGLVILGMAIIAFCCVKQRRAGRREFSMENSKFVEDQNNVMAMRTQWNHKYKPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLL1</accession>
    <name>D4DLL1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_08085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017919.1">
        <property type="nucleotide sequence ID" value="XM_003017873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLL1"/>
    <dbReference type="GeneID" id="9579797"/>
    <dbReference type="KEGG" id="tve:TRV_08085"/>
    <dbReference type="HOGENOM" id="CLU_074873_0_0_1"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="272" mass="29775" checksum="D6701E154BDD33C3" modified="2010-05-18" version="1">MATRRQNKKPSDGPSIPLAAVDNNKKASPGHKTLYEIAAERQAELLTSQHRQTSSNDGKTPPKMQYVHMNADGEIVHSPLPDTPETAPATAELENSESLPPLADTIFLSLSLSCIHFTLSFLAAHQFAQEIEFDRIIFETLVVAFPVMTLLIHFVHGHMVTFPKISLLSLYPGSGKKTANETSGQLATRKSLILALFPPTAHNIIFLTFSVFLGSRLIAMANEASYYAAMKKTPALGTLWVWAVVEMTAGFSVLGLAVPVVWAVWLKGHSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZE2</accession>
    <name>D4CZE2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025661.1">
        <property type="nucleotide sequence ID" value="XM_003025615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZE2"/>
    <dbReference type="GeneID" id="9581900"/>
    <dbReference type="KEGG" id="tve:TRV_00184"/>
    <dbReference type="HOGENOM" id="CLU_128288_0_0_1"/>
    <dbReference type="OrthoDB" id="10295564at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="180" mass="21163" checksum="DE814263686A046B" modified="2010-05-18" version="1">MEEVFSGIKYAFDYLFRSRAARGLPDDRKCRVAYWLMDYVQCALCHFRSEVKTRYPHRVDIIDIAEKVERSIIYEHGGMEPKTLLRTLRGETPRSKPLTPEGLKTCDQILARWQDHDAIKKEFYFLKLDRIIEEGFMKGSFVDDDDVLLSTYLYDTEKHASQTANGMKKWLLARHGTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP7</accession>
    <name>D4CZP7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025527.1">
        <property type="nucleotide sequence ID" value="XM_003025481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP7"/>
    <dbReference type="GeneID" id="9581764"/>
    <dbReference type="KEGG" id="tve:TRV_00289"/>
    <dbReference type="HOGENOM" id="CLU_2147690_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="112" mass="13373" checksum="2579369D50103F91" modified="2010-05-18" version="1">MRTGGGDGRFAQEELQRALQQGRDDRRRRRRARTRQDGSKGRLSQDSQDLQDSRSAVSTGVDGLLVLFWGGRQCQWKRSRRDDEEKKKKKKKKKKKKQKKKRKEKKMTDIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZQ0</accession>
    <name>D4CZQ0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025530.1">
        <property type="nucleotide sequence ID" value="XM_003025484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZQ0"/>
    <dbReference type="GeneID" id="9581767"/>
    <dbReference type="KEGG" id="tve:TRV_00292"/>
    <dbReference type="HOGENOM" id="CLU_1797849_0_0_1"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="144" mass="15939" checksum="CA1DCBE7A954446C" modified="2010-05-18" version="1">MPATSSEADVIFNRANVALARSQRLIASWLPPKTADETANAKSEEELQKEEDEIFTAVPEKLGLGAPIPQKEADGSIKRTELSSNDKLREQLLGKNFQKTEASRLKNANARTKQTGPTPSQKKEIVEESDEEDGRGGSWWEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZT5</accession>
    <name>D4CZT5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000017">
        <property type="protein sequence ID" value="EFE44887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025498.1">
        <property type="nucleotide sequence ID" value="XM_003025452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZT5"/>
    <dbReference type="GeneID" id="9581734"/>
    <dbReference type="KEGG" id="tve:TRV_00328"/>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="214"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="34388" checksum="0893CA270501F785" modified="2010-05-18" version="1">MHVPKKNKRANAANLASSTTGTLGTSILSGVMASLSEPRSSSAYPPPSGSATPSEGLPVHQIPSKFIACVRRPESVKRIQHILSPYNLPLTILQNENVKGVTDGDVIVLGCKPYMLSEVLNVPGMREALKGKLLISILAGVPAEQIEEVLYKDSDLDMADRCRVVRAMPNTAAIVRESMTVIASTNPPLSHFQSTIVSWIFTRVGRVITLPPHIMDASTALAGSGTAFVALVLEALADGAVAMGLPRAESQLMAAQVMRGTAGMVLNGEHPALIREKTSTPGGCTIGGLLVLEEGRVRGAIARSVREATVVASQLGKGVQGVNGTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY2</accession>
    <name>D4CZY2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025436.1">
        <property type="nucleotide sequence ID" value="XM_003025390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY2"/>
    <dbReference type="GeneID" id="9581692"/>
    <dbReference type="KEGG" id="tve:TRV_00376"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_1_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="689" mass="79424" checksum="571C90E2C3983756" modified="2010-05-18" version="1">METTNVSSGLLGPVYTALPEIEWNGRQGFALFIVAILSLHLFNVFKESLFGVKAPMVGYRSFFEPKWLLRLRFVRGSMSIIRGGYSKYKDSMFKISRNDADILVISNKYVDELRNLPEEELSGIEAHIRNLLGSISTTHVMLETNLHTRVLQTKLTPALGLIFDDMKDELNFALETELPECKDKWVPISINHLMLRLLARVSARIFVGRANCRNEEWLSASIDYTENIFITVMTLRMMPRYLHPFVAPLLPWYWRIRSNLATAKRFIGPIIRERREAEARQGKDYQKHEDLLQWMMDGANEKESNPDMIAHIELLLTLASIHTSSMATSNVMYDLCAHPEYFEPLREEMLSARREDGGWRKTTLTKLRKLDSFLKESQRMNPPSQLAFNRVVRSTLKLSDGTVLPAGTHFNIASDAIMNDPAKLPGGGDPEVFDGFRYERLRSDPAHPENANRFQLAMTDSNNLHFGHGKYACPGRFFASNEIKMIITELLLRYDFKYPEGQERPRSLSADENLYPDPDARVLIRRREESVLLLAGVTVNPTILSLNKLQDCIWLARYIYNYMTSGFRREYYVINDNCRNQNEETVVVKSVGHFGIHNEQDIFLHFQDKTNVLRPLLDEIKDSSAPHSIILRYLDDDILHAADWATMQLISLLYGEGFHIFRPDVPVDHDDYSVKILMKHHRCFGPFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D019</accession>
    <name>D4D019_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025423.1">
        <property type="nucleotide sequence ID" value="XM_003025377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D019"/>
    <dbReference type="GeneID" id="9581659"/>
    <dbReference type="KEGG" id="tve:TRV_00413"/>
    <dbReference type="HOGENOM" id="CLU_175691_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="91" mass="10861" checksum="642DFBDB0D984714" modified="2010-05-18" version="1">MVEKMVRMEVGGWRLEVEGEEEEEEEEKREDGEKRQNNEVSKEGKKKKERKGKGKKKARKKAKKRKKRKKRRASGEQEEKEEKEGKSQPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D039</accession>
    <name>D4D039_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025372.1">
        <property type="nucleotide sequence ID" value="XM_003025326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D039"/>
    <dbReference type="GeneID" id="9581607"/>
    <dbReference type="KEGG" id="tve:TRV_00433"/>
    <dbReference type="HOGENOM" id="CLU_067676_1_1_1"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28326" checksum="1BA2E74F94FBE32D" modified="2010-05-18" version="1">MKEDAPILYPNQPVGERVGTYSKEHSTGIPKHIIEYHEHVRETLPDTANYMISISQAQAMCFLAKTVGAKRILEVGVYVGLSSLVWSTAVGPEGKITGLEFDSNFAKLAEEAFEKYGVKNVELVVGDALETLPALVPTEPYDMIFIDAQKRGYPKYLETILKCSQPGSQNRLLRPGGLIIGDNTLRCGFVADDSEDNPWRQHNWGEHRREYWKSEDIISLRAYNDAIVKSDRLENWLCPLWDGVNITRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0S3</accession>
    <name>D4D0S3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025143.1">
        <property type="nucleotide sequence ID" value="XM_003025097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0S3"/>
    <dbReference type="GeneID" id="9580636"/>
    <dbReference type="KEGG" id="tve:TRV_00668"/>
    <dbReference type="HOGENOM" id="CLU_1670652_0_0_1"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="158" mass="17703" checksum="8A0B8BFA5A465EDA" modified="2010-05-18" version="1">MLSSTRSRLCLFAAQSSRYVQRATYTSTVPRLSENTIPTNNPNPQKPVTSISETNAREPASMQETVEHAQKQLSMQAPNRATTWAKNQQERSKAMAGPRFEQTIIDFQVSQLIMGVFRGCIWNNEEILCQLGTLHVLLMNCGLIGDKTYSLNLMPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0V9</accession>
    <name>D4D0V9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IQ calmodulin-binding motif domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000047">
        <property type="protein sequence ID" value="EFE44515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025126.1">
        <property type="nucleotide sequence ID" value="XM_003025080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0V9"/>
    <dbReference type="GeneID" id="9580619"/>
    <dbReference type="KEGG" id="tve:TRV_00705"/>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128576" checksum="1277DFF294BB480A" modified="2010-05-18" version="1">MSRAQKELQPWREIGLGVCLLSNKRRKRLAGRLLSPSLVFSLVLFGPVEGGEVLYREQGGGGVAQKRNEPSDSGHCSADYGVLRPRPGDGDTTAGGLAATAGDLLTSAARSRAYLARPPETPREAKKATSQEDERSPVLRSSVLCSLLSALCSLLSAAGLQVHAARQPADQATLPPSRTDTMACPDDVDAHSTAPAPVSIPGDRPQDIEMAADDSAARHALPPRLAARFNRVSATYRRASLPSISRRNSASSIHSNLTVHGAPHGDPMAPHIRRNLILESRKARLADRAAHVEKVRLRAALAKNGTKTAAIKEERARAAQKTRERLLADITAKCEEEVRRAKKKAEDTEERKAAQRARLRLEMVEKFAEAERRRQLYQETPRRRRTSSIPTVPAAPAAEGIRVTSPGGGHTKPAAIRLTPSAAAHVIQRVWRNHRSRVLVGKYLGLNLTLERIGLLGFERTGALVASETTLDVTAAMLRLCGLQDTQGGALGERGAVRIFLSSYVIAAFPEHVLSSDGEQEQDLIAKARELLVIFQNLLDKIAVRGLTNVSLSPNMLSLSEAYNMFVSAFHAWKSRDSTVLIEIMVAQFTELELIWQTVKNDRAGGVADDYQQGIRYNQTLLLARLKRLVGSEKAMKLIKKSLKKAKSTKQANVATENTIPRAVDKPSASAEALTESSKPPFEEMLHYATANLPESRLEEESISPQDRLTRVLTALPNNRTLVHELLINRDYRIEQDHYTRVRRQIMNHVCDIMRREVAAGYGTKWTVALATVIQDRLLRFLKQGNSLHNLITEVLDPAHIEKQCNSGTFSYDTFFDFMGNILSKLCAPFRDAVVEEFAKDKSGDEIDRLSRLMGIIDLLSLDHTNFMLQVVSPQLIEEAPQYEQRMFERDLQNGSITLDSTREFWKSNLSMFGATDSQPIMGKIYAQGMVDLVLSNTITSQRRIPETLHADYARLGQLRSQGFKIAATASILLTAKNLLKRDVRSQWKSEADRILSLDWHDIKAERIQSIIDSTHPMPTAARSQLLSTIKRVVGPALVAANAASALAPPSLSVTTTFQSFTVRPSPSPSDAGSDASGNPASFTDPVARLMLTRLRSHILARLSATNTRERVKMTTTASQGLASAGMPEFVSEVGKIVETLDKVREVDWLCHGLVHEKIWHEISSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D134</accession>
    <name>D4D134_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000049">
        <property type="protein sequence ID" value="EFE44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025043.1">
        <property type="nucleotide sequence ID" value="XM_003024997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D134"/>
    <dbReference type="GeneID" id="9580535"/>
    <dbReference type="KEGG" id="tve:TRV_00781"/>
    <dbReference type="HOGENOM" id="CLU_010194_5_0_1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="378" mass="41190" checksum="E6B3DF1C954F8374" modified="2010-05-18" version="1">MCFGGTGGAHVEAYIELLSAARRREVKLLQPARPVGDRQNSGFTADVIGRILSSTVLAPQATIPLLLFAGYTSQGRSLIADRPGVFTALKALASIGLLRIVNGFLNRRALNNWASDEFVWRREIALVTGGSDGIGQRIALLLARRGLKVVVLDVQEPKYHTPPNVTFYKCDITSSAAVAETAAAIRADIGEPTIIVNNAGILRTRPLLKSTEAETRLAFEVNTLSHYVMAREFLPSLIRHNHGMLVTVASQASHVACASMVDYAGTKAAALAFHEGIASELKIRYKAPRIRTVVIEPGFCKTSLIDGMSSEDTWFHPLLHPDTVAERTVEQILTGSSGRVILPGSTGFFAENIHSLPFWLQNFIRDRCEMSTRTSHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D158</accession>
    <name>D4D158_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025001.1">
        <property type="nucleotide sequence ID" value="XM_003024955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D158"/>
    <dbReference type="GeneID" id="9580493"/>
    <dbReference type="KEGG" id="tve:TRV_00805"/>
    <dbReference type="HOGENOM" id="CLU_1082554_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056090" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28881" checksum="BB28C6D78F7B93AE" modified="2010-05-18" version="1">MTCALPLSLSCLSVSVSLAEGKDEDDYQLPIFDSRRLYGPVHQVLSLPLSPSVYMSMSMSLLIVPRLPFPRERLCLPASKGEADMKLVCLSFFCLFLDFFVFVSSSPMVPQLAFFAKKKKKKKKKRTGTGTGGRRREDRLAWFDGLESCNLLCHLGFLVSPCSFTVVVVVVVVVDIIFLTSRVTCLFLDGFFFFASAMMASSLTAYSHGGYRRINPVRNMRWGTREKKRRRRDQDVCFLLSLSSSPSTFTLSASLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1L3</accession>
    <name>D4D1L3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000054">
        <property type="protein sequence ID" value="EFE44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024889.1">
        <property type="nucleotide sequence ID" value="XM_003024843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1L3"/>
    <dbReference type="GeneID" id="9580380"/>
    <dbReference type="KEGG" id="tve:TRV_00964"/>
    <dbReference type="HOGENOM" id="CLU_016785_0_0_1"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="367"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="553" mass="62206" checksum="343BFACD1DC7F1B8" modified="2010-05-18" version="1">MTTLNELINRAIFSISAPDPNDPILECYGYEVQKLKTALLDTPDSALQLADANLRIFPFKDVKDCWRRLYTDASLIKACQLLKKHIQRSDKAGHVSGKKVDNAQQVCLSGSLDEGRDEYLEADSPTLYPWVSDVIHILDKALIMTGAPRRTRLIEDLLSTFQGSLRLDYVTSFISSIPSGQTELPHLLPSRPAKRQKLGESSSLFPLDYAPQPSLRNPVPRVAELTFEEFTEHIWNIRTPIVITNAINHWPALSSRPWSSPKYWAERTFGGRRLVPVEVGRSYTDEGWGQRIMPFAEFAKDYLWRSTSSTGKEAQTGYMAQHDLLTQIPALKEDICIPDYCYAEPPAPEPGTPLYKKNIQQADNGNSSKEVQQGEASMPHGNKGKFTEYHDSVDGEDGLSDNITTADPIINTWIGPSWTISPLHHDPYHNILAQVVGAKYIRLYSPHTPASQIYPRGKEVVNHKASDASTMEKKGDAGQEQIDMSNTSQVDISAIELSPAEVEAWEELWPGFFKAEYVETILQEGECLYIPIGWWHYVRGLQAGISVSFWWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2C0</accession>
    <name>D4D2C0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024607.1">
        <property type="nucleotide sequence ID" value="XM_003024561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2C0"/>
    <dbReference type="GeneID" id="9579931"/>
    <dbReference type="KEGG" id="tve:TRV_01223"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="75"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="210" mass="23082" checksum="03561B96B79842E9" modified="2010-05-18" version="1">MSFTRAVYGSIASGLAPTRYTVTSHITRFRHRPALIRPALLGTSSMIGFLSSFLSSSSSSASSKNMANYPEKRTDAEWRAVLSPEQFRILRQKGTERAFTGEYDKHMPESGVYQCAGCSAPLYKASHKFKSGCGWPAYFDCIPGSVKRLEDRSFGISRTEIVCSNCGGHLGHVFKGEGYDTPTDERHCVNSISLKFNEDEGGAKASKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2P5</accession>
    <name>D4D2P5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA exonuclease Rex3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_01351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024520.1">
        <property type="nucleotide sequence ID" value="XM_003024474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2P5"/>
    <dbReference type="GeneID" id="9579743"/>
    <dbReference type="KEGG" id="tve:TRV_01351"/>
    <dbReference type="HOGENOM" id="CLU_022453_4_0_1"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="425"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE43909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="656" mass="72554" checksum="C5F4AF27E469348D" modified="2010-05-18" version="1">MFSSLGLFSAVPCPQNNQCTVINCIFSHQEVKNAATFLSTADSKERANPRPENIDEPIRKRQRLYDDGGTVSGSSGQEIDAAVVERTSTTVAERPKSSPPRSKGNLNSLGRRVSPPLVNRTATRANVAEPLAEDHDKRTSDTSSVMQRRQIKKETLNPRHLSKPPATHVIRTSILVKLHSVMVRLNEELKKSVDPSKKCMILSADELVSMALDEEEKIAKESPAVYSNVVKLRIVKLTKMKQQEWQETVTAFLRTEDSPKIIKPEGPPPKPLSTGLTAEEEKLVLSTLCASTRDLKELEYVMIPPSIDEISAAKRGIEASQGWEKCDRCNGRFQVFPGRRSDGALTSSGPCVYHYARPIRPPKQKTEHVVGQKEFYYPCCKEPVGKSTGCTKVDSHVFKVTDMKRLAATMQFERTPRQPGKKILPPVCVDCEMGYTTLGLEMIRLTAITWPEGKLLVDVLVRPIGEILDLNTRYSGIRSEQFAKATPYKTEQASTATTKKHESKSTNNLEMVDSPATARELLFQHLQPETPLIGHALDNDLNVCRIIHPTIVDTVLLYPHPAGLPMRNGLRALTKKHLGRDIQACGGTEGHDSIEDTKATGDLVRYKVGEKWKVLKRSGWTIRDGELVSPAGNGVSQGSWASDAGIGVKRKAMDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X4</accession>
    <name>D4D2X4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_01430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024467.1">
        <property type="nucleotide sequence ID" value="XM_003024421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579689"/>
    <dbReference type="KEGG" id="tve:TRV_01430"/>
    <dbReference type="HOGENOM" id="CLU_000536_3_2_1"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="entry name" value="AAA_lid_3"/>
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    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
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    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1373"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1571"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="321"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="382"/>
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            <begin position="409"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="11">
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            <begin position="420"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1421"/>
            <end position="1443"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1543"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1571"/>
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        <location>
            <begin position="1600"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1729" mass="191101" checksum="82F8F86104CF1030" modified="2010-05-18" version="1">MPRKYEPTLEELVNRSDPEDDDYDDREQRSRRPARKSKSKSKKQTSRKRKRDSDDDIDEDTELSEEEDDLSDDFEDEIEDPNAERNARGSVRRRVATKKVSYAESSPDEDDIDELLEDKEEEKDPEEDLQEKKGKKRKLIVKFPLPTQSTAAEPAPSGRATRSRGRSASVQRQDPMSVGTRQSTRRSSRLAHDDREDIVALSGSGRHVETIRPGTRGPEPVKSLPTRQGQQLSHVEEEDGDGDGSKIPKDEEDESHLDRVGASQVEIMESDPQGGFDEDAPAVAASDNAHPPADEDADGGEPDVEMGEDGIVPESQHDRVEQDEEDDEDDEGPVSRTRSRRNRIQQEPAEEEEAQAEKEGSQPVRRSTRRTAGKRSQPPGDDGSDFEPNEESHEEEELSDSAASLASPQKDDSGNEPRTRRSNRQRYSHSRAESEAREIEEELAELKSTRPRRKKPDIVYEDKPRRTRKSVDYRLIRPELLLPLEESEVEPTGSPSRRGGRAGGSTWQRTLFSTYGPFGGAGPTPLLGGPAGMGANGGVDSDSSDDELAARSKGPGGAPGGMTAASLAPSLGLGMTGQLHPDPAQGAPGVPANYGKIKDKQALADADPLGVNPNVNFDSVGGLQGHIDQLKEMVSLPLLYPEVFQSLNIIPPRGVLFHGPPGTGKTLLARALATSVSTDGRKVTFYMRKGADALSKWVGETEKQLRLLFEEARRTQPSIIFFDEIDGLAPVRSSKQEQIHSSIVSTLLALMDGMDGRGQVIVIGATNRPDSVDPALRRPGRFDREFYFPLPNVEARRAIIDINTRGWEPALSDEFKDKLAASTKGYGGADLRALCTEAALNAVQRVYPQIYQSKDKLLIDPKKINVSFKDFMISLNKIVPSSERSASSGASPLHSTVEPLLREPLREIQERISKLVPRRKALTALEEAQFEQPNDDIGFKREKLQEEFDRSRVFRPRLLIRGEYGMGQQYITSALLNHFEGIHVQSFDLPTLLSDSTRSPEAVVVQLFAEVKRNKPSVICIPNIRSWYETLGNAVISTFTGLLRSIPPTDPVLLLGILEGEAEYEANSDIVRSLFGFSKKNQYFLSYPELSQRREFFQPIIDFIRTSPADFPDPDNRKKRVIEQLELAPPAPPKPPPAPTKEELKAQKRKDRQTLNLMKIRIQPIMDQIRKYKRFRTGVVDESQIRYLYDDDDPNVVTSDLPPEQRSTFRPYEKDTDKAGVPGLREVASGKFYYNLDIVTIEKRLSNGYYKRPKDFLADIKRLAKDAKQLGDPDRQLKANELLANVEVDIGAIDNTDPALVAECEVVYTRELEREKAALEKIKQPVVDADGTMKPPAGPPPQMNIAHGSIELSNVSSAGPVVLGELFNSPCPAPGSKSGPGYPSLTNGHTPGFHPHGGVDGVRPPTSNGPLHKPEGDGDVQMSNSDNTSGTHQNNTQNSSFGPSAQPRPLHSYTAPSQFMRHQSGLSTLSQKGNITPMAPGSQPGDYVNDASTTQTTSDKKNSGPTDLMHTNPHASLIGSAMHDAPDLTLYPDRASGDEHLPETQQGDSSWVSSQMTPLRGVAEFLHSQSTTNANGSQSQPRHSQASQPHPAGPPLLFDATSSRSSGANTHGNPVTPPSRNGEPTRISHLINSEPKQPEPSPPNLKLNLMVDEDFNRELHDELSTKTGGFSVEQLEQINTELMDCLWINRNEWNRREVAIILRDTFLETLDDIKSSQNYVDTTQKLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D304</accession>
    <name>D4D304_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024394.1">
        <property type="nucleotide sequence ID" value="XM_003024348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D304"/>
    <dbReference type="GeneID" id="9579534"/>
    <dbReference type="KEGG" id="tve:TRV_01461"/>
    <dbReference type="HOGENOM" id="CLU_015321_0_0_1"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73566" checksum="A94E98A1DEA4D660" modified="2010-05-18" version="1">MASKKPSSPTPTGRRTPSTDAQTSPGGPRRVSSQSPGATTNGVGRSPSTKGSPGPVSARAAAARRAGLGRSNLSMSSVPRNYPHNNEDEEARAANTALIEDLKEQVQKAETVADQYRKQLGVLQMRLDEAVSEQTRLEEQAHEKDGQINPLRDEIKELHRQIRDLEQKHETERESMMADKENQAKREEELEASIQRLKETIAQKDLRMGVDGERNLSRSHIENGQFAPSSSQLQRSPSRNNSKLILQKDKLIESLRLELAEAQIKIVEMENLGGGRQQELERELLEARMANARLMEDNESYQLLLSERTLNGDFTKGDFMHDAHPPANANGTGGSSLADELDSVGEGGEDNEKRKLESELKSYKDQNKALSLYIERIIGRLLQHEGFEHILDKSDSDNTGPKGGNKDKELPPPPPAEKNEEPGQQQSFLQRAKSVVSGQPARSNNRQRPPSQLTQSTSTHSPPQSSPREPPTPSAHENPDTAPRIPLGRSRTVQHRRTRSDQLDNSGAAAGTASVISQMYRGPPSGRSPSTGPISPGISPTLSNNGPFFAPGAASKRSSVATAPGGTGTSISTRSADRRFSGAASLTSDRSGDVGSMEGGAASASPPRSGPGMNNYTGAVMQQNKLRPLRLVQENQEMDADPLTDEAARKKANRGSWAGWFNRGSFTMSDSSNSRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D350</accession>
    <name>D4D350_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Alpha-glucosidase AgdA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_01507</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000080">
        <property type="protein sequence ID" value="EFE43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024309.1">
        <property type="nucleotide sequence ID" value="XM_003024263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D350"/>
    <dbReference type="GeneID" id="9579467"/>
    <dbReference type="KEGG" id="tve:TRV_01507"/>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="214"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="507"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="17">
        <location>
            <begin position="613"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="826" mass="93832" checksum="B5E2AC5E6E41C18A" modified="2010-05-18" version="1">MLATYIQCVLMGIIDERLHVIIEDSKEDVYQVPESVFPRPESEENDSASTKSALKFSMTQKPFSFKITRRATDEVIFDTSNSPLIFESQYLRLRTSLPDEPNLYGLGEHSDPLRLQTEDLVTTLWNRDAFGIPPGTNLYGSHPVYYDHRGRSGTHGVFLLNSNGMDVKVGSENGDNGKKYLEYNTLGGVLDFYFMAGPTPKEVASQYAEVVGLPAMMPYWGFGLHQCRYGYRDAFNVAEVVYNYSQAGIPLETMWTDIDYMDGRKVFTLDSKRFPIDEMRALVKYLHDHNQHYIVMVDPAVSYGDNDAFERGKTQDVFMKSRDGAIYKGELEALPLYLLYTKSSIGAVWPGVTAFPDWFHPGTQDYWNNEFKLFFDPEKGIDIDALWIDMNEASNFCDWPCSDPEGWERDHDLPPAPPPVRPIPRPLPGFPDKLQPGSVKLVKRDGTRLRSQAGLPGRDLIDPPYRIQNEAGSISNKTLNTDLVHANGLVEYDTHNLYGTMLTIYRLGDNLSEWSQYRFSISQILQFAAIYQVPMVGADVCGFGGNVTEELCARWAMLGAFYPFYRNHNDIAGRDQEFYRWESVTEAARTAIGIRYKLLDYIYTAFHRQTQSGDPVLNPLFYIYPEDKDTFAIDLQFFYGDALLVSPVTDEGATSVEIYLPDDIFYDYYTGEPVEGKGGLITMENVPITHIPLHFRGGQIVPMRADSANTTTELRKQPFELVICLDREGNAEGSLYLDDGDSLEQPHTSEINFEYHNGVLKVSGKFDFQNEEALEIKNIFVLGYKQDMTVQDKGNKNKDSQYDERLKKLAIKAKILLTGPSEMTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3E5</accession>
    <name>D4D3E5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH signal transduction protein PalI, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000083">
        <property type="protein sequence ID" value="EFE43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024254.1">
        <property type="nucleotide sequence ID" value="XM_003024208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3E5"/>
    <dbReference type="GeneID" id="9579374"/>
    <dbReference type="KEGG" id="tve:TRV_01605"/>
    <dbReference type="HOGENOM" id="CLU_030208_0_0_1"/>
    <dbReference type="OrthoDB" id="4174427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055283" evidence="3">
        <location>
            <begin position="21"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="622" mass="66231" checksum="0B163C44C8D23F63" modified="2010-05-18" version="1">MLPPTLIQLLLLQSCASALATTPSIRSSARPDSCSDQLGCLKQDDSKLPRQFDHLWIWDEISKAKRADDDKGKGEGRKEGGRGKEGSQGEDQEGGRGPPPGPENKPPPGRPDKNDRPNNGRDNNGENKDKDGKGSSGGPETGSGKGGGDEEGDKDKPKKGGNEGGNGGGNGGGNGGGKENDPDPPKNEPPKNEPPKNDPPKNEPPKNDPSKNDPSKNDPPKTDSPPPVPTQQPDPPRDPVPNRPPPDPMTQQPDPAPSPTRDPTTEKDPGTRTNGPQPTHEDPSPSQSPPPESKPSAEPTEGPTTTKDPKPNSTDPVPASSSSEPSGSSKSPEQTTSPTGDPAESSNVPPAPTSSSSSTPVTSSTTPPGPPKSKGSSLSKGGVAAGAVFGGFVVISLIFLTFVYYKRWKHTRENQTDEGSSRRLSPFPPTPPMGNVQQTQTGIVDHNESMAYDHNMSSFGVLSSPSQGDSYPHSMEEKGIAYSTYPSHQDAAYQPSLSQSAQNELHLPQGNMGNTTQSNLLIASSEHQHQYMAYSPDLMEDEKTGFHAVGAPGLAPLPESSQENLHLHNSSEEYRRPIPKRYSAEFLFAYLFLVSPLLLRDATYIKITGTYLWWTPLTDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3X3</accession>
    <name>D4D3X3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024019.1">
        <property type="nucleotide sequence ID" value="XM_003023973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3X3"/>
    <dbReference type="GeneID" id="9582711"/>
    <dbReference type="KEGG" id="tve:TRV_01786"/>
    <dbReference type="HOGENOM" id="CLU_125080_1_0_1"/>
    <dbReference type="OrthoDB" id="2989864at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="126" mass="13964" checksum="2DA3BBAE5BBF060D" modified="2010-05-18" version="1">MFEHFTAWHLPPLFVATATTFGGLMPFWNAAYAIEEFGLPKRIAVSKEAQAIMITASGRTTALGLALFTFYSQNKLREVDTIMFILGYLGLVDGYVCWREGVPGKAVFRTVSGLLIAAWGWFSMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A0</accession>
    <name>D4D4A0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000100">
        <property type="protein sequence ID" value="EFE43355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023973.1">
        <property type="nucleotide sequence ID" value="XM_003023927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A0"/>
    <dbReference type="GeneID" id="9582666"/>
    <dbReference type="KEGG" id="tve:TRV_01915"/>
    <dbReference type="HOGENOM" id="CLU_101420_0_0_1"/>
    <dbReference type="OrthoDB" id="4588567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="213" mass="23051" checksum="680C53663326FF44" modified="2010-05-18" version="1">MASKPAVHDLISLFEAIETSESKMDEHTRYLSQLLPSPWTEMAPSLTIPYSPRSTVGSEVDSDRPSPLTSATSSPASSPTSSPISASPRMNRFTSSLRRIGSRSKKCYSSSSLGMGTILLRRRPSNVDLALTEERYRCTEDSIERRGLGLLEPRPVDPMPLMADGHAHIDSSNNLSSVTSDLKEPSALLSPLSARQSPRFVMGGIAEVMEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4C2</accession>
    <name>D4D4C2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023887.1">
        <property type="nucleotide sequence ID" value="XM_003023841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4C2"/>
    <dbReference type="GeneID" id="9582519"/>
    <dbReference type="KEGG" id="tve:TRV_01937"/>
    <dbReference type="HOGENOM" id="CLU_1455399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055559" evidence="9">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="186" mass="20048" checksum="9AF1D4C072E383D1" modified="2010-05-18" version="1">MISEGSMYLFVVFWSPAIISASKDDDIPGSPPFGVIFASFMTAMMLGSQISSQLMVSPPSREDSSPTPSLSSSSSSSSTEPQNPPSYDFNRISVSRSSCLLTILLFLGSMSLTCAVVFPTTLLTLWAFCVYEFSIGLYYPNMGVLKSVLIHDKDRAGVYALFRLPLNCFVVAGLAFTTEGETCVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4E3</accession>
    <name>D4D4E3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023908.1">
        <property type="nucleotide sequence ID" value="XM_003023862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4E3"/>
    <dbReference type="GeneID" id="9582520"/>
    <dbReference type="KEGG" id="tve:TRV_01958"/>
    <dbReference type="HOGENOM" id="CLU_125044_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="124" mass="13858" checksum="58A7942CBB2DC09C" modified="2010-05-18" version="1">MIASVNSIKTWVMSSKGRMVKIAKGSGTAGTRAAPTQSGTNDEKMGGRLDFGERFEKDGKVYCRFNFQLNKNAENKTLRDLARDNTHKKWSSAEIEISENPTEDEAREKATQLFDSIISNLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D585</accession>
    <name>D4D585_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023623.1">
        <property type="nucleotide sequence ID" value="XM_003023577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D585"/>
    <dbReference type="GeneID" id="9582169"/>
    <dbReference type="KEGG" id="tve:TRV_02255"/>
    <dbReference type="HOGENOM" id="CLU_045148_2_0_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="300" mass="34028" checksum="E0C7376CFD5C52EE" modified="2010-05-18" version="1">MLNDLGPELFRNRPQTLRTLYTAVLAVAIYNCLELVLLIFMTFSKYEGLYFWSLLLATVPGVLTDAIFLLMYYYMKLPPAVAFAFASIGWCFMITGQALVLYSRLHMVLHNRLGLRLVLAMIVISAILFHIPDIVTGFGSIVPNPARPQFVRAFHIMEKIQLTGFSVQQFILSGLYLYLATGLLAFVSAKARRKELHRLIAMNVTIIIMDVALVVFVYLNWWVAHESLKPFVYSIKLKLEFAVLRTLVSMSKSASANLPDFVDPDRLEGDVSAAEHAEDETPLQSNNNMYVFNKRSKTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5N5</accession>
    <name>D4D5N5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000125">
        <property type="protein sequence ID" value="EFE42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023454.1">
        <property type="nucleotide sequence ID" value="XM_003023408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5N5"/>
    <dbReference type="GeneID" id="9583472"/>
    <dbReference type="KEGG" id="tve:TRV_02408"/>
    <dbReference type="HOGENOM" id="CLU_065832_0_0_1"/>
    <dbReference type="OrthoDB" id="3921745at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33392" checksum="119900E19A4F9424" modified="2010-05-18" version="1">MASTRYGLPSPKSPTESSKRIAINTLLNPESVSACDSRCLYPTRKPQPPYVDYPDRRERYSSGSSTTISSACSTPVNTSFQGYNQTHFRPLQYLNTGYGSYDGRPEPTSAASDSYNFTHHHHHHHSTINGNANATGKAPVSPTSSPTPYRRERFPSVSSGTSSAPVPERRRPPRPKYDEEEMYFIWYHRVDLGQEWKQVRECFNAQFPNRQRTGFQGIQCKYYRFIKEKNCPTLREQRRKRSAAAASAAAGGETGSDSEGRAKGHNYGGSNCHFNEDGPAYGVIRWTGTRFPWMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5S2</accession>
    <name>D4D5S2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023343.1">
        <property type="nucleotide sequence ID" value="XM_003023297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5S2"/>
    <dbReference type="GeneID" id="9583362"/>
    <dbReference type="KEGG" id="tve:TRV_02445"/>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="289" mass="32238" checksum="6C9D93F3AD14C456" modified="2010-05-18" version="1">MCFFGNDDDDMPPARYIDPPEGSKFITSGGSGLIYSSPAIRGEIYKICSHDPDSKENIEREKLIFQNMMSVGQHPHVVRCFKVIENGVILERAEHGDLREYYQAGGVATIYERIKWCKQLASAVDYIHGLHIRHADLCGKNILLDADRKIKLCDFAGSGFCGNLPTVSAEIGYAHPNRDQNRRATVKAEIHALGSTMYEIITTRRPFSSDNEPGVVAHWLNNGVYPSVYHLPLGDVIMGCWKGRYPCALQVQRAIELAISEGLSIPIHVFWYTSPLMLNVLAGMDALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5V4</accession>
    <name>D4D5V4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_02477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023375.1">
        <property type="nucleotide sequence ID" value="XM_003023329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5V4"/>
    <dbReference type="GeneID" id="9583395"/>
    <dbReference type="KEGG" id="tve:TRV_02477"/>
    <dbReference type="HOGENOM" id="CLU_159427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16217" checksum="42BFFBE4CD8EA485" modified="2010-05-18" version="1">MGTCVNIATAYLISRVKVQTLGVVSALVTMIAPILMATIKVGENYWFSPFWALFLSPVNPDVISDAFPPDIQSLAGGVFNEVAQFGNSVGLAVTASIAASISDHKTIQDHKERLMLGYRGAFWTIFSSCALVVIISFFGLRKGGTVGKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5V9</accession>
    <name>D4D5V9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_02482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023380.1">
        <property type="nucleotide sequence ID" value="XM_003023334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5V9"/>
    <dbReference type="GeneID" id="9583400"/>
    <dbReference type="KEGG" id="tve:TRV_02482"/>
    <dbReference type="HOGENOM" id="CLU_018993_0_0_1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF195">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="281"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="806" mass="88647" checksum="FC181532E365E4EE" modified="2010-05-18" version="1">MSKSMFRSPQDDSSSEESGSISSEEEQENGHTPRQDGNSSSAQDIEPTSSSLDTESTAGEILGGGGGGGSFYGDLGFRDIPDVDAEGHAALMTAALLEHYCLTKACGILNEQSSSRGQYTLESPEVKLLGRRLYTYQSKFLSSHGIVAPGVDNDSWESTRQYYREGLDTIGMAALDGLNLNARAVQTPIDTPQTPLMALGTKEDDAVAGENRMFSMKQPTNISLQRLITGRADVSQSQNQFTSGLLNRLQRQATPLARSISIPFLYSHPSGVGGSRYATEFEEEALIGRGSYGMVYRVRHHVDGQDYAVKKIPLSSKKLQQLQERGLREVDNILKEIRTLAKLEHVNVVRYYGAWAEYSPTPVTSRSSSPPKRQQTLLNTPYAEYDGSASSCGIVFEESDHGVVFEEPSKPSPAHEEEHEPSMDRLSTGEQDRRRGSFATVSSERSLKSFVASVEEGETDTIDDEHVESIPRQLNFTYSGQTSASESGPDIFSDGLGGGGSNMQLDRKSRPDTAAPVTLHIQMSLHPLSLAKYLVPQVDSGSPSVPRHCYHIIPSIKLLLGILSGVDYLHAKGIVHRDLKPANVFLSPSDTEQDTHLCPICRHDGHDQKIHYSVPRIGDFGLVAESPTYGKSTIPEDLPSMPARPVGTEFYRPPAHSFRAQSSGDLHPYADNSLDIYALGVILFELLYKIDTRMERQMVLSNLTCSPSNLPQFGESVPDKKECSCPALPADFTDKIVRNCINHGRSKNDMEHDHSLSAMAKDIAKRLAMCIMGMVELDIRHRSTCKKVREELEEIRDLAESLWKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D625</accession>
    <name>D4D625_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000131">
        <property type="protein sequence ID" value="EFE42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023322.1">
        <property type="nucleotide sequence ID" value="XM_003023276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D625"/>
    <dbReference type="GeneID" id="9583342"/>
    <dbReference type="KEGG" id="tve:TRV_02548"/>
    <dbReference type="HOGENOM" id="CLU_012079_1_0_1"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="72"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="447" mass="49117" checksum="8A22E1BEDC379A59" modified="2010-05-18" version="1">MTLVLLLSILAIGFSSVAFIQLLPTRREKKSSETHDAVSVQIDTIVCLLWLPRSSSNSPTLNRVADSTPNQELLDHPLISIVALPSPPALLQTKKKFLFPVAAILEVLQQAWHLWTALGYRTGPAHWILVQNPPAAPTLALALLACHLRHSRLIIDWHNFGYSILALKLGSAHPMVKLMAWYEKAFSCYATAHFCVSNAMARILREQFEIKKPLMVLHDRPSSAFSPIFDEKRRLAILSSIPETSQSATDIIEGRCRLLVSSTSWTPDEDFSLLLDALCRYSTSAKSSVLPSVPLLVIITGKGPLKDMYLSQIDKLKAEGKLFNVFIKTAWLSFENYAQLLACATLGVCLHTSSSGVDLPMKVVDMFGAGLPVVGWDQYEAWPELVTEGVTGLGFDSADKLSGLLKSVLGGDGSALKVLREGAVKESRNRWDQTWDPIAGTFLGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6E4</accession>
    <name>D4D6E4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored cell wall protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000140">
        <property type="protein sequence ID" value="EFE42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023206.1">
        <property type="nucleotide sequence ID" value="XM_003023160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6E4"/>
    <dbReference type="GeneID" id="9583226"/>
    <dbReference type="KEGG" id="tve:TRV_02669"/>
    <dbReference type="HOGENOM" id="CLU_1300473_0_0_1"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056230" evidence="2">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="260" mass="26792" checksum="08A6CDAD4BDBD2F1" modified="2010-05-18" version="1">MMLKSVLSALVHLGLAAAASSSSAPASTTQSGSPSPTISIFFPNTARPTDGPIVTPLADASVVSVKEPLTTVAVCINFVSRHSCEADMLQTFTVGGTTLLEYNEVNTDEGMTGMLTVETRTIHGGCTIHEAATCSVSFSTAIASFSTNMVETTTYPASEVTYVPVTITAGAEKLPKATQTSGTGGPSGTGKPNSGPKATGMPNLALLGGAAVFGNVYGISTEFWISAWKDIIADIDWVASLKISAKFGYSSASPERVPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6N4</accession>
    <name>D4D6N4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023071.1">
        <property type="nucleotide sequence ID" value="XM_003023025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6N4"/>
    <dbReference type="GeneID" id="9583091"/>
    <dbReference type="KEGG" id="tve:TRV_02761"/>
    <dbReference type="HOGENOM" id="CLU_054777_0_0_1"/>
    <dbReference type="OrthoDB" id="4507588at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44137" checksum="F0108A897760EFDA" modified="2010-05-18" version="1">MAPKGGKGGGGGGHYGGGRHGSSSSYSSSCASGAFKDGAIIASMVFLSIFLLTFLCLGCLTSNKSTAMKKRNQRKSRSLWWALSLSLTLITASTDNYELLSIIRTWFKNWGTLLLIGVIMVPLCKHLHQLAGKVLGRVVAIGHFVVMVIMAILLVCYLGLQSSLPSIRANYRVLDTLSKVTSGLGATYNVVAFIGTCLASISILFAVIRSSQIQNSWAKKWIFFVIIFPVLLTFFDVVYGFHFYVRGQPYTTTAFAVFTFLWNLFYTMSYLAVLYIVSEGSLAPVTQPGAIDPNDPTKGTYVPVQPGPQPPFQNVNTAYNSPMQQQQQFQHNMQTQPPMSQPGFEPTRNDFSPSPPPQQPQYYDPVKSPESQALMQGQTYEQPAPQYQNYQQPAVPQPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q2</accession>
    <name>D4D6Q2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Toxin biosynthesis protein (Tri7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_02779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023089.1">
        <property type="nucleotide sequence ID" value="XM_003023043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q2"/>
    <dbReference type="GeneID" id="9583109"/>
    <dbReference type="KEGG" id="tve:TRV_02779"/>
    <dbReference type="HOGENOM" id="CLU_032731_0_1_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="243"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="410" mass="46441" checksum="B6B29F7A2A564EA1" modified="2010-05-18" version="1">MEIHPILLGGAVVASSALAVGFTRPSSIYRLAVAPILTFCTFRCITTSMDYMIRCPWAGLVGAYTITFFLHYLDIVLLRGWSFEAGGPSTDPGTGENIPNYPKKDRTDNTWERLKFGLAATCSFRHIGTPYQVKNVPRFSDKNPEYVPSRSRFLIWTAFLYAACYLFLDLITFKVDIDTNLKYFTQKNVPFFTRLPNISSDEIVMRVINTIISGLIMICVQRSFYSLVGFFSVLLGISEPREWPPYFGSLSQAFTLRRTWAVFWQQTNAAKFASVSSFIVQRVLRISRGTQLYRYARLVTIFAISALMHVLVDVASGLSLTSSGAARFFLTQAFGIVIEDIIVGIYYNFMVKDRSRGSYLLEKCVGFVWVCAFMIWSSPTYVYPLMYRVNSGQDDSIIPFSIIKMLIPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7H5</accession>
    <name>D4D7H5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000158">
        <property type="protein sequence ID" value="EFE42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022833.1">
        <property type="nucleotide sequence ID" value="XM_003022787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7H5"/>
    <dbReference type="GeneID" id="9581557"/>
    <dbReference type="KEGG" id="tve:TRV_03057"/>
    <dbReference type="HOGENOM" id="CLU_078549_2_0_1"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="19135" checksum="996536D228EEC849" modified="2010-05-18" version="1">MLMVFFSFAFVEYESRRDADDAYHEMHNKRIGRDDVLKIEWARTPPSASWRFDSGSDRRRERTPPRRSHRSPSPRRGRDYSPRKDDRRDRDFERRERDRSRSPDDRDRDRDRDRDRDNRDDRERRESERENGTTNGDERKVPMDSPPPAHDELDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7R6</accession>
    <name>D4D7R6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation regulator (Cya5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000162">
        <property type="protein sequence ID" value="EFE42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022727.1">
        <property type="nucleotide sequence ID" value="XM_003022681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7R6"/>
    <dbReference type="GeneID" id="9581416"/>
    <dbReference type="KEGG" id="tve:TRV_03150"/>
    <dbReference type="HOGENOM" id="CLU_003430_0_1_1"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1214" mass="139394" checksum="B6AE27D3FC86DECC" modified="2010-05-18" version="1">MLERAVRCIENASQHVYLGSKHTFRSRHILHPKFWHCNTDDSSALSLLYYYAVQSRLGKRPPAQHNNDDAPLDSILPPTPLEFLYPPKTRLFARTYKSEPKRNLNKRKRNIYRTYSSSASNCLTEESLDTGNSFTNDVRSNESPDVLRKFLTDKGPRDYGAAWWLYRSSGSPRGFESDLLSYLSTSQDPRDFQRCQLLFERINPTNRSERDYLSTVKIALNAKSRAYTNFALELCGEASARGQTQCWQYAFMEFVNRMDWENALSVWNLQPHPLPNKLPAVDRQSKPLANRLLALLEVVQQRNTNDTTEMARYIVQLVISHDRAMMSVSMNELLKIFENSIKLELFNHDDYILAIRSLLSSKIRSANGRSIMLYRNFRWRIPQITPPKALIMGLLHMLCNIEVLEGVDYLLDEYRLHYGKPPLLAYHDALTVSARLGDTSSTLRFYNDYTADHGRADSTEILTPLLYVHARTGDVKETQKWFNHVSELGVEPRVQYWNILLTAYSKNKNLEGALRTFQQMLQSGMAPDAVSFTILMGLSAGRGDIRAVLDLFDMAKRNGVRLQRSMFDTMVEVLCKHRRYLDAEKVAEEATSKFPASTMTRTWNILLWNYAYTIDITAVLRIQNRMQDAGIQFDGMTYAAMMSSLVRVGKTNSARKILGVLHRNHEIHLTLFHYAILLHGYVQETNRDMVQVLYTEMMERFNKTGLSGTLAMLQSQIDRDIRRARETMGSASSAKFALPHAEKLLKTAMAQLDTQDFSTRQPQPGARGRSLREAFPAAFYEQLIRAYGRNNRDEKVGELFLEFSQKSRSTLPDRLPHSPMILHALMVNFLAKNQHYEVKKCFEAALTHTLQRSRGINVQAALSRPTGFLAAPRVSKKGPAEVTFCTKTPTVLPSHRFDLSHCISTYMRSLSSQNLHLKIADLVTQIEKLGFAFSTHNWSLYVNILCLSRDPASQMRAFTIFEEKFMPNYPGWRYIKRGYTLRPEGAHMEMDLMEGPFRRGKPGRMIGRKVRALWAKVQPDYMQPTHLNILHLASALIDFRSRSIVDGGKEMNELFSKAPKTYTAVATIPYLEEKFQNILRRYKADQADIERLPRVEISNDDVRTGGVLGEGSERINTGEVESSFEEDNDVREDEDKSDSEWTPEIHEQPNVFESTEPAPPLLESLLAEDMSRRQRMGVSEKSTAVPFAERVLSPEDQWDLDNYIRRSTFEETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z4</accession>
    <name>D4D7Z4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022641.1">
        <property type="nucleotide sequence ID" value="XM_003022595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z4"/>
    <dbReference type="GeneID" id="9581300"/>
    <dbReference type="KEGG" id="tve:TRV_03228"/>
    <dbReference type="HOGENOM" id="CLU_2996142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="57" mass="6814" checksum="C08BF057D5D8D9E7" modified="2010-05-18" version="1">MSTDQKSEEKINQDISLRNNNIDEEQNEISKDLPAYQNDPFGDEEFSDVKYKVMTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8P6</accession>
    <name>D4D8P6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022419.1">
        <property type="nucleotide sequence ID" value="XM_003022373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8P6"/>
    <dbReference type="GeneID" id="9580966"/>
    <dbReference type="KEGG" id="tve:TRV_03483"/>
    <dbReference type="HOGENOM" id="CLU_045550_0_0_1"/>
    <dbReference type="OrthoDB" id="4173544at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="385" mass="42415" checksum="114422DD56E74955" modified="2010-05-18" version="1">MGGCCMNCDPFRCFRGKEELDSEEEVQITVSDGSTIVDSADSSDSLAPQLPPINRLSSLHIPGVQPPSPDPQHDILFSEEPSPSSFAEMIYYHNGSAGLPQSDMDALNRCHAAALGRGSVQACQGPTLRNPPATMGPRIIDKAPDISFDPLTEAMQAMAEELKEEQEPEKTLEDPARSQAKNEDGCKIALVPDPVAEARAIASRIVVPGPEETEEKDGSHVAFTVDIKPPPRPLPLNWKPSQVVDRVCKGMDAMMEVRAGINRVLRDKPDYVVGLPYTIQHKKELEMRALGTVIRFANCIAEDKRLHDEKEPIRLLVTCFEILVQCTSASLAAALTAAEDSKSPEEDEAIRLQVQRWLVQTFSDIWVLEKETARYLARFAMDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Q8</accession>
    <name>D4D8Q8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022431.1">
        <property type="nucleotide sequence ID" value="XM_003022385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Q8"/>
    <dbReference type="GeneID" id="9580978"/>
    <dbReference type="KEGG" id="tve:TRV_03495"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_4_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="169" mass="18632" checksum="E9A980191B00C7C4" modified="2010-05-18" version="1">MSTHLHSLSPGDTLLIAAVIPSYSWTPNKHEDIILIAGGGGITPLYQLAQGILNNPDDTRTKINLIYGVNNESEILFQDQFDQWRHQFPDRFKATFVVGSPEPGSPHEKGRINADLLSKHMVLPKTGEKSVATKVFVCGPPAMEAALVGKRHDGILKQIGFTKDQVFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V3</accession>
    <name>D4D8V3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022330.1">
        <property type="nucleotide sequence ID" value="XM_003022284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V3"/>
    <dbReference type="GeneID" id="9580877"/>
    <dbReference type="KEGG" id="tve:TRV_03541"/>
    <dbReference type="HOGENOM" id="CLU_503404_0_0_1"/>
    <dbReference type="OrthoDB" id="4200179at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="570" mass="62289" checksum="9C1F0B3EB342EAC2" modified="2010-05-18" version="1">MLYKSIDLGSTIHMQKDHEIQLYISSSVQIAHLNDSPCLEELSIENLRRQDVWVSWGSNSTIQINISVKIQTSLATKVSIPGTLRTISGLLTLPSVWSVYGLDATQDGKLHQNETNTLNITLQARPTRDQATSCELNNIPTSLSALLDGNPHIQPPAEIPTIFVRDISIQLVFSNGSSSPILLPQSGDNYNGPLNVLLSDSDGWESLDDSTPFSSQELTSTRFSGNSNYGSSTHECPVSGSHNISPIRSIISLLNSGLLNLLNIPSPDTRSIQSMPSNGHQVSLAELSPVIFSPGYKMAMFQRLSFVPLVIKGMASMIRSMDSKRCESTTSKICDIYRFKSYTAGFGTAPVSSGIRDMLRYILWVQTQNSLYSANKKPKRSHLFATTVSKQQGILGCPANTLRKANSVEALVAISGCSDSDWHIFEDEEEDDILLTDEVYSEEQEEWYKSPSLSESIIDNDGFHFITTPEIAGLVPDQDGILSSSPCLLAEVDIGPILERSGEEHDCNTGIPMDPGAGNDPTMEILQSSSPIILPLSASQGSPCNDDIDRSEELDTLPRLDSSDVEMMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8X1</accession>
    <name>D4D8X1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022348.1">
        <property type="nucleotide sequence ID" value="XM_003022302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8X1"/>
    <dbReference type="GeneID" id="9580895"/>
    <dbReference type="KEGG" id="tve:TRV_03559"/>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056086" description="ACT domain-containing protein" evidence="7">
        <location>
            <begin position="36"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="355" mass="39382" checksum="A4871908625127C2" modified="2010-05-18" version="1">MLRPSKKKKKRKEIKWILELLLLFIITHKLPDSKGEAKEIKGSLAPPGERRYHQQQQIRLSSSSTSALAYKALHRRSPPPLPVSDTSPQWSAPAAVSSILYETPVPSTKPPKRHVLNCLVQNEPGVLSRISGILAARGFNIDSLVVCNTEVEDLSRMTIVLRGLDGVVEQARRQLDDLVPVWAVLDYTDSALVQRELLLAKVSILGPEVFEELLQHHQEMSTPESDTNNPSSEEAQHREMHKVDGSLSEIADYHPNRLAASEALRHKHEHLEAITHLTHQFGGKVLDISTNNCIVELSAKPSRINSFLKLISHFGILESTRTGLMALPRSPLTSPAEEVEKEAADIVDTSTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D904</accession>
    <name>D4D904_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022270.1">
        <property type="nucleotide sequence ID" value="XM_003022224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D904"/>
    <dbReference type="GeneID" id="9576866"/>
    <dbReference type="KEGG" id="tve:TRV_03592"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="552" mass="61299" checksum="EB2269B4FEF0D18E" modified="2010-05-18" version="1">MPFAQASSLEAWKALEQHHTTAGRHIRLNEEFQKDSQRFEKLSRTFYNEADKSETLFDFSKNLVTDETVSLLVNLAREAGVEELREQMFKGEPINFTENRAVYHVALRNVSNQPMQVGGKSVVEDVNSVLEHMKQFSEQVRSGEWKGYTGKKIKTIINIGIGGSDLGPVMVTEALKAYADRSFDIHFVSNIDGTHIVEALRNSDPETTLFLIASKTFTTAETTTNANTAKDWFLKTAKDEAHIAKHFVALSTNEQEVTKFGIDKKNMFGFESWVGGRYSVWSAIGLSVALYIGFDNFHQFLAGAHAMDKHFRETPLEQNIPVLGGLLSVWYSNFFGAQTHLVSPFDQYLHRFPDYLQQLSMESNGKAVTRNGEHTKYTTGAILFGEPATNAQHSFYQLLHQGTKLIPTDFILAAESHNPVEGGKHQRMLASNFLAQAEALMVGKSPEQVKAEGAPDELIAHKTFLGNRPTTSILAQKITPATLGALIAYYEHVTFTEGAVWNINSFDQWGVELGKVLAKKIQKELETSGAGGDHDGSTSGLIAAFKKKASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D970</accession>
    <name>D4D970_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022257.1">
        <property type="nucleotide sequence ID" value="XM_003022211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D970"/>
    <dbReference type="GeneID" id="9576859"/>
    <dbReference type="KEGG" id="tve:TRV_03660"/>
    <dbReference type="HOGENOM" id="CLU_2764973_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="70" mass="7137" checksum="E746520E6DEB64E7" modified="2010-05-18" version="1" fragment="single">RAGAGAGGAGEEQAGAGPCHPEAAFVPLEHAVLELTKEEGVLVEAVDGQAKKMYVPVASSREAIVLLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B0</accession>
    <name>D4D9B0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022177.1">
        <property type="nucleotide sequence ID" value="XM_003022131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B0"/>
    <dbReference type="GeneID" id="9579071"/>
    <dbReference type="KEGG" id="tve:TRV_03701"/>
    <dbReference type="HOGENOM" id="CLU_038840_1_1_1"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="446" mass="48322" checksum="3F4746229A75F939" modified="2010-05-18" version="1">MNSLPPSLHTPLRRYLTQCARRNLTRQQPRWLSTSHTLRATTTKTGTREEVRYSTKAARDQNARHKRSMAISAAGLIACAISMYGTVTYYFPDGLQPETNADNNDGQKSQTAASKTKGDGKIKLEGPPGGVALNESSTVIIDGIEQVPTGNSTIPNFPKTIRLPRTVDGSNPDLKIGDELPATDNVNDKSADEYQLLGLGLRTVSFLSIQVYVVGLYIATADIPELQARLIRQGANPVVPGVAPTDDGLAATSLVPHEREELQASLLEAEKGEQIMDHILRQGGIRTVFRIVPTRNTDFLHLRDGWVRAITARAQKANARAKQLATADKSASDVSTAVEFGDDSFGTALSEFKTLLGGGVRKNVPKGQTLLLLRDKLGGMGIIYQPGDTKPMTWLGRVGDERIGRLVWLNYLAGKTVASESARKNIVDGMMGIVGRPIGTVEMKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9B4</accession>
    <name>D4D9B4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000189">
        <property type="protein sequence ID" value="EFE41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022181.1">
        <property type="nucleotide sequence ID" value="XM_003022135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9B4"/>
    <dbReference type="GeneID" id="9579075"/>
    <dbReference type="KEGG" id="tve:TRV_03705"/>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="207" mass="23136" checksum="2BE34701C81850C1" modified="2010-05-18" version="1">MATTATIPEGGTWLDTMKRSFEDVPVDESSDNAISTTEFLEAAESLVKLFDILGSVAFTPVKNDLLGNIKKIRDRHLAAPAESETLQALVLNELKTKQHKATEGLVWLIRGLDFTAQAFSRNLSMESEELASSFREAYTNTLKPHHSFVVKPIFSAAMSATPYRKDFYAKLGSDEQKIHAAMKKEICALEKRVAILNEFLARKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9E5</accession>
    <name>D4D9E5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000192">
        <property type="protein sequence ID" value="EFE41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022133.1">
        <property type="nucleotide sequence ID" value="XM_003022087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9E5"/>
    <dbReference type="GeneID" id="9579030"/>
    <dbReference type="KEGG" id="tve:TRV_03736"/>
    <dbReference type="HOGENOM" id="CLU_296990_0_0_1"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="918" mass="100593" checksum="BF8C72D07FC2B078" modified="2010-05-18" version="1">MSVKNSASPASSGASPAVEEEPRSPISTKMDGFKRRFSRSKSNFQRRLSLTSNGDNNAASAAVSHPRAPDPASPALVGLGLIGGGSTAAAAVGGHHGNTDAPMPSPQNPPSGQPRLVSARRRSFNISTRFPLFSKSRQHTSHQDDSVFHYKSNPEPLRRSWTDVGAATDTAATTTTSAAYPRPRSASPARAISPSEQGYTHLGTFKFGSLHVVNGCASPAPSSKKQRSYPDLNAIEQLDSKPETETEQVQEPLPEMETVMVRAEEPVTMPAIATPPPPIPKRSSSRLNIRRSEGAVEAQHLPEFATQSSPRSKPKLTPLVTSRRPSVSWFDDCPTSPAGFGSPDSAHLRPLTPPSVQPTPMLVTTTKQTEHDDNLFEDEGMEIPVFWDDTVQSHESFHDPHFHSSLSKERQETTKLESSKRSGALNKTDSGYSSASGKSASRHRYTSSRQRNSRDRNGRLFDGDSNQALIHCDGGINDPVEGTISITSHGDKEIINAVFPWPPAHLRYPVEPYTSQEIRPKQQPQEPTYENKADSMSEYNLDPTYPVRAKFEPSRPPPIPPRFRQSMQVSRPRPADSQHTQCKIPSPVGLAIEISPKCISPREPSPKDRTHRSSNNERSSRSHARSHAKGSSHKSYSSKEHTTKSHASASNMTKSNPPKSSTTKRPNRRYRDSTPARMTGGKPPTAPHVHARSASDATSSRPSKGINKDKPLPALPPPGHPRFPEAQMLTPPLSRSTSMGDLKLLTDTSPADLINYIDNHTPVKIDNNLWGSLSTDPELDLELLPLNLDLNKSALDNYQPRKSLQESINQSTATTRQPKKLHRSASHFSFSSSINQKPSGRYSTFPPSPVRDVFFDRKSRKAKYQSTPPTSYRFSQLKSTVTERRSSHLPGAPSTTCAAQMALAHQKPGALNHIESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9I4</accession>
    <name>D4D9I4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000194">
        <property type="protein sequence ID" value="EFE41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022110.1">
        <property type="nucleotide sequence ID" value="XM_003022064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9I4"/>
    <dbReference type="GeneID" id="9578994"/>
    <dbReference type="KEGG" id="tve:TRV_03777"/>
    <dbReference type="HOGENOM" id="CLU_085810_0_0_1"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="189" mass="20642" checksum="34D6DFC1531D3BFF" modified="2010-05-18" version="1">MVAGPALRRALIRANWLVRSPAAGPAYYSTAAPTDVSALLSKPTWSVKSLLPASQQEDDAGISPKQLRHLLRLAALPQPASQAEEAEMLKTLASQIHFVKEIQQVNTTGVTPLRSIRDETADAQKENTIDLALLKSALEREEFVGRTRRIRRKPAEKLEKPDGEAWDGDALKAASKTMGRYFVVQTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Q7</accession>
    <name>D4D9Q7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome segregation ATPase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022033.1">
        <property type="nucleotide sequence ID" value="XM_003021987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9578917"/>
    <dbReference type="KEGG" id="tve:TRV_03850"/>
    <dbReference type="HOGENOM" id="CLU_000589_0_0_1"/>
    <dbReference type="OrthoDB" id="5423371at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2103"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2165"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2276"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2221"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2280"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2299"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2313"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2348"/>
            <end position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2360" mass="261197" checksum="EABAB7A955832BA0" modified="2010-05-18" version="1">MQPNDKEENRDRELVLRHHHTPSESRSLIPMWDSADPKRAPPPLPLNPGGPNSPVTRSNASATVQAAAAALAEKSQETTPSSYTVNPMPLKPTSPEKSLIKGQYHKRMQSLQNATNNNEFASYLERRSSPEKYRRNSVFDRDDRSADTTPTRGGAADTTTPNHDSPTQARISNRYLNKPILGENTPPSATMLALRDMQIPMDLAMPAETPSKPEKPTKMPESFDALSAQIVSLTKIATSLQQEMSQLSRRSKDNATDLISLKAATNARDEDIRKSLKDLTANLSSKIFDPDPHTTTPRGTPYIHPATGGFMLGDSKPHESSPSSRKSFSGARMSSPGSFAAALERDLAASPGPISDGSASIALLEKVLREMATKEGQEKLLTLMEDVQARPTEKDNTMTMMLSEILNLVKENSGSRALVRSRGDMGNQLFGDKPQTPDFGQGTRSGPMGLSASPTPIRSNSDSNINASLQPSNPLADDLMAMLKRVKQSVTEGGGITSEVKALVRELRGEVLGMGRDIARKLEEAQKTKSIDSQVPSGPGKEEIEQIVTGALVDLRQQMDHIIEENARNTASTAITRPIPDSQEIYAVVKRALHEIPLPQPQLPPPQDLEPGLQRDEILETVREAWETYKPEIELQNFGLERDEILECLSEGLKGYQPQEEPIDPDVVYQQVLDAVHTELQSFEPPRIEPDISSIREAVVSAVQESLKGIEWPAPQAVEKEDTLKRDDVLSAVQEGLTSQETLKRDDVFAAVQEGLSHQEILKRDDVVSAMQEGFAFQEPLKKDDVFGAVQEGLSSLPEPLKKEDVLSALQEVLANQEPIKKDDVLSAVVEGLAAQEPIKRDDILSAVQEGLANQEVQPREIEINRDDIFDALRLSLEDASGALTSNLGEQLIEHLHGMILEMKDEFKEYSAANGRDTEQVLDATKDGLEVLRGQIESYIDRTAGANGKDEIIDTVKDGFRLLQSDVEKCIRESTERNPSDTVELLDAMEKEFEHLRQTLSSLLIRSNTTSDKDEILDAIREISDSDALKKNTSNSEDKDEILNAIRGISESESFKNSHSELADTIKQELEHLRQTISMAIVKPESSLDKDELLSAFKEHLQAAFEEHHERKDGNESIISNTNELLDAFHDGVEQLRAEMDKLHDKPIEPSVDKELLENLRDEVAGLKAGMDRLIESQKEAEEANTARGGEIMLAGDASIGGDIDGLKALVTQLQTKVEAIEVNPVVPERGEDPDMVKKNDLAEVLNAIKEVHGSVNEVAASSNAAREAPEKEVDPDAVKKDDLTKVLDAIKEVHGSVNEVAANNSATREAPAENVSSASKEEIEALQTLLQGMKTQLDEITPSTSATWVTAEKVEALETLAKETKETMSVFATHIDIEGPTKEDIKNLEGIMKDVWVVVEEIKTAQNPEKEEPKEDPEKVVKGDVKNLETLLFELKAQIEELVLPDVNTLPTKEEITNLANTVNEFKEKMDAENELTAQAFEARKVEHGGLAEKIEEAKLFIVDFREDFKTKLTESDGTLGDIKTILECLNDSAESFAKADTIKELSELVKRESERSHGDHEATKVEAAERGTALLEKIEEHRNGLKADIEAEIDKKFQEVITKYEDAQLLVDSKFTAAEERDAQGLEALTSTKAVAEDLKLVIGGMGQSLTETCDKINDDAKTFFGRVDESFERFDHLHEEMKSFTGRVDESFGKIDNVREDMKAFTQRVDDSFGKVDNLHEDMKAFSGRVDESFGKVDNLHEDVKAFSGRVDESFGKVDNLHEDLKAFTGRADESFGKVDNLHEDLKAFSGRVDESFGKVDNLHEDVKAFSGRVDESFGKVDNLHEDVKTFFGRVDESFGKVDKMQEDVMLQNEDMKAQFDKAVAATDRIESQISQTHPELLSSIKEILAVVGQHYEHSQQSSKDLKTDLCALPNSITPLLPALLPPPPEVKEPQFEKYDDTLMHEKLDTIISHASNKESSDAQMEKLNALQEQLNATAREVSEMMASHSKKTIQDYEDKKEEAMEAALALERRLAQKESVEAEVSALKEEKERLLQSIRELREEESELSRNRIKLAKEVAGMETALRIRQEEVHLMEDRAEDLERRIVEGVLDHARSQLVSRHSGSDRMSLKRVPSTASTTKGGGILGSSVGMALNRRMNKRTNGSTVPNGKNERRILSLSNVSGNRGNPDRGPYSGSHNGLASLKRSHSVKTSQGYRRQSCDTRLLGSNKENESVREEEESMSEVESDAGTERRTSYTGTYADSVSYITGSTVSQNRSASYCSTNVDGSVAAGSESWQEPSELSRVTNDEQSEVADRAETEEHSSSELESEESEDEEEDDEEEDDEPTLHALKAKEGDMVLYHQTTDSGVGMTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9U0</accession>
    <name>D4D9U0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000199">
        <property type="protein sequence ID" value="EFE41371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021989.1">
        <property type="nucleotide sequence ID" value="XM_003021943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9U0"/>
    <dbReference type="GeneID" id="9578873"/>
    <dbReference type="KEGG" id="tve:TRV_03883"/>
    <dbReference type="HOGENOM" id="CLU_001366_2_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="131"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="423"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1233" mass="141426" checksum="9E24D90122E81F00" modified="2010-05-18" version="1">MEIFCRNLPEQVQEKHLIKELKPILEHFQIHVFDFQKVGRKNSRITVADVRKGQHFLDTYESRMKPVRGPGRPSRTPATLKLYGMPVYVSKSTNIPHKQLLQSLCEEEEERLNARFAPAPRSIAGKIDRVRHFKVTMMSCGSWDYRANQPVFVEYFRFPCPGVIHIGKTAFEALFTDIRSMVKTSMEIPYWNVADDIYVGAYAKPSVTITTEVAPRFYISDPIEQMKVQMAALLQTKGRPPPPKRRVGYITSGHEKISARCFTYRFALQDPRDTGVVRNLAHDRNVPKMSTWNDMCVCPRRPYKLLDREFGAYLVRMPFDYRVKFQLLKLVWNGELSLDQASLLLPTVHRLHQQHSSDIVAQALMRIDGNSVYPSPGVLASDASIEALTETLEKSLDTILKARTEWDINLMHEKNVLVHRATVTPAGIYLSGPYAETKNRILRKYLDNIDYFIRVEFLDETGDPVFFDPSANLEQIFHQRFAGVMKRGIEIAGREFEFLGFSHSSLRAQTCWFAAPFTTANGDYLNARTIIGNIGYFDHIRSPSKQAARIGQAFSDTLTSISVSKEVVWMRAPDVKRNDRIFSDGVGVISRDLMYRIWNEYALREKVKPTVFQIRIAGAKGMVSLDTRRKGEFLMLRESMVKFPTDDLYNIEICGAGIRALPFYLNNQIIKILEDLEVPFEAFHQLQQDEINFLYSTFNSTERAAKFLEDSPVPKSLRLPWLFLVLKGLGIRYTQDPFLKRVMELTTLLRLRDLKYRARIRVPNAVTLYGIMDETGYLKENEIYCAYLGGDGRREILVRDNVVITRSPALHPGDIQVVNAVDVPANSPLRKLHNCVAFSQHGDRDLPSMLSGGDLDGDLYNIIYDTRLVPRKTIPPADYPRVEAKELDRKVETEDIIDFFVTFMQQDQLGRIATTHQTIADQSEFGTLDQACLKLAHLHSVAVDYSKSGIPVNVFSIPRAPRVRPDFMAPSPRFRVADSIESIIGEKKSTMQDDDDEDEDDSDHRRIRYYKSNNILGRLYRSIDERSFLCQLRDAGAVDINTNTNVLRSIWNYVLSEVDGFLWTHLKGIFYDTRDMYEPPFTSFFLDMFMDIYRADALGIISYEDELRELMRKYSATPLKSSISEYELFVGTILGHGHKQRRRDKDNAKEMRDEYNRLVEFTISMIRGTESGGTEALERSIACFWVAIDGKGSGQKPGVRSTHAHQDKLLSFPWIAAMTCLDEVDKLQRYAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAF7</accession>
    <name>D4DAF7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021773.1">
        <property type="nucleotide sequence ID" value="XM_003021727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAF7"/>
    <dbReference type="GeneID" id="9578653"/>
    <dbReference type="KEGG" id="tve:TRV_04104"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_8_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1194" mass="132066" checksum="ACC460EED72FD024" modified="2010-05-18" version="1">MAIQNEGSAIIDSQPRPVTLNHNKNEPEEGQSVTSGSGWQMKTPKNEGCPPVAIVGMALRAPGGVKSPDELWRLLLEKKNGICEVPGNRYNIDSFYSENKTHMVKTRHGYFLDEDPACFDASFFAINSHEAGQMDPQQRKLMEVFWECLESAGETDWKGKNIGCYVGVYGEDWLDLASKDPQYTNRYHILGTGQFALSNRLSWQYDFRGPRFFTLWPKFKWLSRIYTNCLPLVADFYYTNCNQGLHPEWRSGDDDKPEQPGLSPEQWEQQLHTAGFSGVDAISFDFDAPHQTSFSILSSAKPSSSPKTDVTLLTGDTPCPWTKKIASSLEKIGYRVHWGRLDQSPPTNQCIVSVLDLESPYLHNLSEEKYIALHSYLTKIGKSRMIWVTRMNQLECSDPNFSIIFGLARTLRNEMGLDISTFETDMFNSAAINGLSKVLDKIEWSRASSALDPDYEFAFHNGSIYNGRCHWMSAQSQMPIESLGETPRKLAIKSIGSVDSLYWQPFADATELTGDEIEVDMHYIGLNFRDVMVATGLFGDPKEFGIEGSGIVRRVASGVVDFKPGDRVFVLDTGAFRTRVVKPAHTVLPILDTMTLEDAATIPCVYLTSIMCLETFSRVREGEVCKKIGAQIFATVGNEEKVQYLVNEFGIPRHHIFNSRNADFLPGIMRETGGRGVDVVLNSLSGKLLHTSWQCVAPFGKMVELGKRDFLSNGRLDMAPMMENRSFIGFDLGHWINADHGILRHQGSLKPIRPIKVYDAADVSEAFRYMQQGTHMGKIVIRLPQDLSAIPLAGVKAPVEFSPDVSYLLVGGLGGLGRSISAWMVEQGARHLVYLSRTAGQTDKDRAFIRELEDQGCHAVCVAGSVVNIADVRSAIAQCPKPLAGVFQLSTVLKDRTFSKMSYEDWTTCLNTKVQGTWNLHEALQNEKDLEFLVLFGSVSGVCGNVGQANYAAANGFLTSFTQYRRQLGLPASVLELGIVDEIGMASENEAALQNARSTSLRLIYENELIEGVRLAIYQCRNPPPADSLTSSSSIIGLGNTKPLTEPGVRPLWARDARFALYSNLAGNGNDGTAGEANNGVKLLLSKIGQSASYLNTEESKSILQGVLGMMVRQSMAHTQDMDEDELAGVNIDSLTAIEMQNWFRRNMGLEISLAEIGKAGVVGNLAETIHGLMKVKYGVTGKQDGADPENDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAK0</accession>
    <name>D4DAK0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000209">
        <property type="protein sequence ID" value="EFE41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021749.1">
        <property type="nucleotide sequence ID" value="XM_003021703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAK0"/>
    <dbReference type="GeneID" id="9578629"/>
    <dbReference type="KEGG" id="tve:TRV_04147"/>
    <dbReference type="HOGENOM" id="CLU_1751028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="149" mass="16721" checksum="B11A4CF7940C238B" modified="2010-05-18" version="1">MHVSGSGVAGWLAGEAKRLFFFFPGSSRDHEERDPEKGSRKAKTANSKSKRKAKKGRKPKKETRGKMELELETPRGLRVAREEEDSRGRLSRKRAKSKRAKRERPVGRAKDDLVGCSSAGGSRRAQEDSQRSQRVDGWLVGMVRDELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAV5</accession>
    <name>D4DAV5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000216">
        <property type="protein sequence ID" value="EFE41005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021623.1">
        <property type="nucleotide sequence ID" value="XM_003021577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAV5"/>
    <dbReference type="GeneID" id="9578584"/>
    <dbReference type="KEGG" id="tve:TRV_04253"/>
    <dbReference type="HOGENOM" id="CLU_098335_0_0_1"/>
    <dbReference type="OrthoDB" id="4203959at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="184" mass="20684" checksum="FD1D7AADCB9D9D28" modified="2010-05-18" version="1">MIHAYLSRATVISLILYLIIHKKMWYRKLFWREKASQRDENNGASPSTHPDFPCHPLYREGIRAASTQTSPKLPEAQTPAPSTPFRYHPYHPQPPNAYYQPVEVYRTLMLPDEILETHAGQAHGSRTNLSAAKGSQDELSATPHSRPDASEAAPHPVPITHPAQLPIHSPQPRRMGLPVSPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB01</accession>
    <name>D4DB01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000218">
        <property type="protein sequence ID" value="EFE40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021591.1">
        <property type="nucleotide sequence ID" value="XM_003021545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB01"/>
    <dbReference type="GeneID" id="9578552"/>
    <dbReference type="KEGG" id="tve:TRV_04300"/>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="350" mass="38700" checksum="A862E8B037E159AD" modified="2010-05-18" version="1">MSLRPCLRSPLLRRISPLSRTYAVQTPGNPTLEVFNRRTKLLQKDRAAKNVDTSRQVDYLKDEVAMRLSDRLLDIKRHFPNVLDLGANSCNIARALTSTPISNGEGDASTGTGETVADRISKITCIEESRSLLYRDESLPFNSQISITREVIPSIENLPYEPNTFDAVLSSLSMHWINDLPSLLAQVNSILKPDSPFMAVMFGGDTLFELRTSLQLADLERRGGVSPHVSPLADVRDIGGLLTKAGFKLLTVDVEDIVVEYPDTFALMSDLQAMGESNAILRREAGPISRDVLLANEAIYRSLHTEEGESNIPATFRLIYMIGWKEGEGQSKPLERGSGQVNLKDIIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB18</accession>
    <name>D4DB18_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000219">
        <property type="protein sequence ID" value="EFE40957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021575.1">
        <property type="nucleotide sequence ID" value="XM_003021529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB18"/>
    <dbReference type="GeneID" id="9578536"/>
    <dbReference type="KEGG" id="tve:TRV_04317"/>
    <dbReference type="HOGENOM" id="CLU_085417_0_0_1"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="207" mass="22188" checksum="49165D013FB0ECE9" modified="2010-05-18" version="1">MGSLQTQVPPQEDDGTLSAVFDNNHPPRLGTDVGIRLPLSAMAAFASGMALGASHGSTKAAFRFRAENAHRFPTNPAGWYQYHKSKNYTSMIGGLKEGTKLGMKVGIGAVAFCIFEETVDHARGNRDFLSTVTAGLSFSGVYSLLAANSVIAHVARHDVYTAARTAKVGLKLSLAYGLLQDLFASFRGSRPQYIQFIFNVFGKPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBD5</accession>
    <name>D4DBD5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021461.1">
        <property type="nucleotide sequence ID" value="XM_003021415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBD5"/>
    <dbReference type="GeneID" id="9578422"/>
    <dbReference type="KEGG" id="tve:TRV_04434"/>
    <dbReference type="HOGENOM" id="CLU_2623779_0_0_1"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE40843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="78" mass="8913" checksum="3462729051B4355E" modified="2010-05-18" version="1">MVLRQLQIQSLSKKLSSTYKLHFRHTSASGKVVQEKTIEAPFSKWFSADGTLHFEPFSEWLKNEIKLVQTSSLEGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBI0</accession>
    <name>D4DBI0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HLH transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021406.1">
        <property type="nucleotide sequence ID" value="XM_003021360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBI0"/>
    <dbReference type="GeneID" id="9578285"/>
    <dbReference type="KEGG" id="tve:TRV_04480"/>
    <dbReference type="HOGENOM" id="CLU_008057_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="194"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118028" checksum="58C6002B75CF2A3F" modified="2010-05-18" version="1">METDKEPRPDETDSTPFDLDIVEESINIADSHIDLTPTPPADQSEEQPKDKAAMFSAQDDLTADWAQWMRWDDIEDTKPSIFNIPNIPGSSLPQSAFTFTSDDAILPTHTLAPSNGSLGLPAVKQPSVSTIFQEQPTIETIQPAPPSDASSPLAPSPTSSVGRKRKSSHDDSPVNDVPQPAAAAAAAADKSAPSKKRSHNIIEKRYRANLNDKIAELRDSVPSLRLTYKQRHGGNLKKSNEDDDIDLTSGNKLNKASILSKATEYIKHLELRNSRLEEENLSLKNRFRELEKAQGINLVSYPAVTGSETPSGACTVSTSSVVTSPDIFSHSSDFSPDSPPNPLFPPEGLLRPPDGFNQLRPTGPQPHYADTFQYNQPQEYDCAPLENASTATAPSSETTTRSRRQFMGLPNKFMLGTLAGIMVMGGFESHRSSDPEEKKELFALPLQFLGSFYRLALQKVYFIRANSWQIRALSQFALTSLILFGCAFFMFLYLFNSRPRVSRVPLKPSRTRNVSAQQQVSTGCSFTEFRQDAWLTSIQTVGVPRHNFFPEWFAVTSRCLEYCVRCLLGWKLYSFVTGISADDEKGRVKAWDIALDAQLTGGDAEVSKSRLVLTIFAAGTLPRSPARMMLKAFHCRVLLWRISSPDSLAFRAANYIAKVLANYQWELAQSMHRRGPKRGEDPLPSHLAFLLSMDCDEVFTDTIVQRASNMVWNRPTQEATDGEDALLDVVVEDSAVRSPLDVLAAWWSSRALQEALLKSLDLVSIESPIEKRKSFERSLDIALHSAPIPSTAYTRATVVKALFFEEDRINNVNTVLSTLPAKNSENFRSTCGLTNFLDSSIPPSARDEIFIGVRCAMIAAILRGQVGRGEDEPASSPFSLSSAIKQFNAASVDEVELTLLGFASHYYLLHITATDERLLPCSSLASSMHSSVVQLTDGSETTTSYQDEHDIPIPDLSRIAADLIFWVRNAYNPISSGLNAKLMEKVVIDCVEVCRNAGVDIDIRKIQRMKTHQRTSSVGPSHTPARSPDSEGVPSGVTPVGVQGRRPSTFSDDTGYGSIDSEENRAIQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBN8</accession>
    <name>D4DBN8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000228">
        <property type="protein sequence ID" value="EFE40714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021332.1">
        <property type="nucleotide sequence ID" value="XM_003021286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBN8"/>
    <dbReference type="GeneID" id="9578223"/>
    <dbReference type="KEGG" id="tve:TRV_04538"/>
    <dbReference type="HOGENOM" id="CLU_048955_3_0_1"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="313" mass="34528" checksum="E4ACF843259767BA" modified="2010-05-18" version="1">MGNDGGSIPTRRELVKEAARNPNTTQLKETLREHLEHFWTTCPISHKKLLSPVVSDAVGNLYNKDAILQYLLPGDDSEAISAKADCDEVLQGRVKSLRDVVELKFDVDGNPDVPNGGRKGRWICPVTQKELGPSVKSVYLVPCGHVFSEGAIREMKSDKCLQCNEPYEPSNVIPILPTQESEKERLKSRVEDLSRQGLAHSLKKLSGSSKKRKKNRTDMNGDVEDGSKAESATNGKVKNDSKTPTPSSTPAPVGIKNAGTAILTAKVLEEQNERRKRAKTERSDAVQSLFTSKNKKENGKNVDFMTRGYSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBT1</accession>
    <name>D4DBT1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000231">
        <property type="protein sequence ID" value="EFE40688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021306.1">
        <property type="nucleotide sequence ID" value="XM_003021260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBT1"/>
    <dbReference type="GeneID" id="9578150"/>
    <dbReference type="KEGG" id="tve:TRV_04582"/>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="245" mass="27368" checksum="E8A5406B44A755E2" modified="2010-05-18" version="1">MFRRALLRQSRLAGSAAPSSIVSPIHRQSAIIRQSQQLAARSLPSRVQSRYASTEANGEKPKAEEAAEAEKPSELETLKKDLETREKEVVDLKDKYLRSVADFRNLQERTRRDIEAARTFAIQKFAADLIESIDNLERALAAVPPEKVDAANAKENKDVYELFSGLKMTEGVLMNTLKKHGVVRFDPSELVDGQPQKFDPSRHEALFMSPMEGKQDGDIMHVQNKGFTLNGRILRAAKVGVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC01</accession>
    <name>D4DC01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_04653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000235">
        <property type="protein sequence ID" value="EFE40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021221.1">
        <property type="nucleotide sequence ID" value="XM_003021175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC01"/>
    <dbReference type="GeneID" id="9578066"/>
    <dbReference type="KEGG" id="tve:TRV_04653"/>
    <dbReference type="HOGENOM" id="CLU_594426_0_0_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="517" mass="56354" checksum="88C9BD918C115951" modified="2010-05-18" version="1">MALLPYQSPPLLPLDSTHRGSLVVIAGAIAGAVTLTGLLIRLYIHLAINPHYGRDDYFLLGSAFVALCQSILIFVSVSKGFGTSADLISHDNLVTLRRAFFSSEILYLVTLYLAKCCVICIFLKLTPKKTHNRATLGTLVYCTLWIIGSIMAVGIRSGILDTHTVRAVSVSYCKLKLVKWRFIVSFDVLSEVIIFFLAVHLIRELQMRFRTKIVVLSAFAARLPIIALAIIRLHYLDICGEQTNLTLDLIDSSVWTQISLNYNVIACTIFALKPFTAAVSTNYGTAGDQSLQNSKNNSNGSTVDNSYSRDLESGTYTSRSKEQSFSRPYTGTSSQHGLKKQKPRKTQLSTSLSRSLAGKEAKSSQHSFPRFSLFSPTSPTAQHQRLKSSDEHHEMTSINGNAPPVPSLPHNQIPKNTHTRTSSRGVRVPFLHRGEKGGSGSMDSHGSVPGAGMIHGPGPMASDTIIDPPAAAATTITTAITAGGGDRTEANPEGDWNDDKTKLIIKKNIEYTVQYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC62</accession>
    <name>D4DC62_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000236">
        <property type="protein sequence ID" value="EFE40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021197.1">
        <property type="nucleotide sequence ID" value="XM_003021151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC62"/>
    <dbReference type="GeneID" id="9578041"/>
    <dbReference type="KEGG" id="tve:TRV_04714"/>
    <dbReference type="HOGENOM" id="CLU_045011_14_1_1"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF18">
        <property type="entry name" value="HEXITOL PHOSPHATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27544" checksum="5A7C557766A8EF27" modified="2010-05-18" version="1">MQITHILFDCDNTLVLSEELAFEACADIANEILEKHGIEKRYTGEQLIGEFVGQNFRGMMVSIQTKFNISLTPEELESYVKEEENRVIAKLEAKAQPCVGVTEVLVKMFAEKKYGMAVVSSSALRRVKASIQKVDQSQFFPEDHIFSAATSLEKPTTKPDPAIYLHSLKVIGKSATECVAVEDSKSGCLSAVRAGIPVVAYVGSYPTTEKQEEMAKLLLEQGAKVVMRNWSEWDKCIAEVEKMDIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC83</accession>
    <name>D4DC83_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_04735</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000240">
        <property type="protein sequence ID" value="EFE40538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021156.1">
        <property type="nucleotide sequence ID" value="XM_003021110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC83"/>
    <dbReference type="GeneID" id="9577998"/>
    <dbReference type="KEGG" id="tve:TRV_04735"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="406"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="567"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE40538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="720" mass="80392" checksum="63F4731D181E5686" modified="2010-05-18" version="1">MAIALAEADKYELLERIGSGSFGVIRKVRRKADGFILCRKEINYLKMSHKEREQLTTEFNVLSSLRHPNIVAYYHREHLKATQDLYLYMEYCGGGDLSRVIKNHKLAGTFAEEEYVWRVFSQLATALYRCHYGVDPPEAGSNVLGPTPKSSGLKGKQAQVMILHRDLKPENIFLGEDKSVKLGDFGLSKQMGSHDFASTYVGTPFYMSPEISAGERYTLYSDIWSVGCIMYELCKKEPPFNARTHVQLVQKIRDGKFAPLPDVYSSELRSVIASCLRVNPDHRPDTAALLKLPVIRLMRKEQEVVEISKSLTSKEEAAAQKLKDLELRYAKMEKEKAAMKAAIESSVRREWEVKARLEIDRQVQMELEKLRRTFEVEVEQRVASEMQKYKEEMAQKHNVDLSQLDSAHHSSMGSSDDTDFPSSTDLSELSLDPPTPEQKNAGKKGNRTPFSRSKTTVESPMDVQMAEPSPVCIASLSLSPRRTAGTSAKNLFADGGRTKPRWDDAIAMYSDDEDDIPDLPSPTRAKIQADPSKLAHRPLMRQNTTAMMQKLTTQPDLFPVTKTTAVRPAQTANSAAPQSTDGRHSSADTRNKSPQRRISKIPSYNNLALEGSPSRKTAMMPPPAKAGTNPGGEEMFKAIMQRNMGGRSLVELAQARAGGRSLDELKRPGDSKIPATTASAPVAATTTVAQLDPPATWDPERDEMPSPFLVRNKKVIRNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCX0</accession>
    <name>D4DCX0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2 family helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020900.1">
        <property type="nucleotide sequence ID" value="XM_003020854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCX0"/>
    <dbReference type="GeneID" id="9577721"/>
    <dbReference type="KEGG" id="tve:TRV_04976"/>
    <dbReference type="HOGENOM" id="CLU_003233_2_0_1"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="877"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129849" checksum="572B163A220B1824" modified="2010-05-18" version="1">MTSTDISPLASPAPCSPADSHISACSSSDTSASPADAEGDQSDCDLNHYIPIGVLWWKLPDATRPDAPQEYRPEADSLQLLEDAGFIKLSVAQEPGEIWTRIQIYLIPESRVPRLPRRHQRHRRALKAVMAKIDASADAWEGRRRNPVQVNNASEAGSGCESLFYIFNTLQSPKPEAAHVSDPWSKIAITNLIYSGDYEDDAGDGNSGIDGLKTRLYPYQRRSAALMIQKEAEPSLSLDPRLQALQSPTGRTYYYDGEQGIVFDEPRFYSNVSGGILAETMGYGKTLICLAVILATRGHMPSIPSEFITSTPIRSETGSLMTMAAAAAGTKSLPWETHFRNLGSNGMYFGKCIDMCNKHRGTYTINLAPKYGNRSGSYLRDSSVTVQLTSSTLIIVPPNLVDHWLNEIAIHTEGLNVLVLRDSSAKTPPASDLSKYDIVLFSQPRFKKESGVYTGSGPVYFSPLRYLRWLRIIVDEGHNFASSGGKTNSVYMLDKLQVERRWIVSGTPSKGLYGVEVTLAAEQSLNSTSEEEKIGGILEARRHAGNILNDEVKRLDSLRSMVIDFLNLKPWANSRAADPASWTTYMTPTGPDGRRAMSPSLRATLQSLVVRHRSEDLHRELPLPSLHNEVVYLEPTCYDKASLNLFILRIVINAITSERTGDDYLFHPKNRKHLSQLMNNLRLAGFWWPGVETEEIQNVTLRVAKDYLQKNIDRMAGEELNLLHQAISIGEKILGFSTRNVLCEKEEVGILVDGFPEYAQGFWEIGERVGHQEPMLLGLSLAREAQKFVVSKLCSLDPGEGLAGAGIKARRQRYQKPAQVEKPSPKKKPEEVINTPHRPKPEKISAPKSSAKKSLPSDSSLKKTKVIGTVSAKLSYLLEKVLQFQDTEKIIIFYESENTAFWIAEGLELVGTDFRIYAHTLKASQKSEYLSTFNEGESVRVLLMDLRQASHGLHIAIASRVFIVNPIWDPNIESQAIKRAHRISQTRPVYVETLVLKDTLEDKMLRRRKAMTSVEMQHAEKDMLNDGTMSSIIQSEGFLPLPDNFASPSPAILSKPFGLFDRHTLPIPEDYVDPTKPAQDHQPELVASDIVSDSLTSDDKRRLANFLEFDSPAASQGRKSPKRRKESHAEEVVNENGIVFISPRSRTPRKQRRGPSSASSSPSSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCZ4</accession>
    <name>D4DCZ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000253">
        <property type="protein sequence ID" value="EFE40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020924.1">
        <property type="nucleotide sequence ID" value="XM_003020878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCZ4"/>
    <dbReference type="GeneID" id="9577757"/>
    <dbReference type="KEGG" id="tve:TRV_05000"/>
    <dbReference type="HOGENOM" id="CLU_014831_3_0_1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="848" mass="92344" checksum="BB63DDAFDE3BF67E" modified="2010-05-18" version="1">MPLSSDELEAPLLSRERPSININTLSTEAEPLRQSTQSPLITPASPTDTEPSALFSPADSHRSQRTAASSISSNDVFLIQDLEESFGLGVDTEDVRASHTTSSMLSYNPLRSPDRFLPIRDPHNPSSLPFRLSRHPALLSPVERSRRLHDPANIFTYPYQAVQRGVEIGDPRISPRQLPRYINHGLLSEHPSNPGEIAHTNRSRAYAVWSFQGGLGVRPSPRNMVCDGRGGLFGSGTVAPLYIADFLTDRSQIQDDLAYETRLAYAINVDHAARVLHSTPQSPLQDKRIPSFNSPDRWSNNVWKTDDSKSPISLTYSAVSPKKLGPKPPRPVPSTPFRVLDAPLLRDDFYCSTLAYCYTARVLAVGLGHRVYIWSEGTAVKHPPFKDYPPSNYVTSLSFSSHTGGHSILAVARQGGRVTLWSTFDSEPRFELKLPHGASSACFKGCTTRRTSSRDGLTSVDVEELAIGDEFGQVWYYSVEWTNAKWRKRYNWNGAIRLLAKISAHTQQVCGIAWSPDGRFLATGGNDNICLIFDVVELTKKTGSGECVVNSPGKARSLSTGSTLSSKLCLLQSYFHCGNSCGSTLSAGTSTPETGAPSPPKGAVEDQPSTKPIYIPAESEKHKFTHAAAVKAIAFAPWQPTLVATGGGTNDRCIRFFHAISGACLAVINVHSQVTSLIWSKTRREIAATFGYASPEHPYRIAVFAWPSCQQVVAIPWAVATGHERFGSLNPGDCGRALWAISYPGGPNEMARQLADPVSHGHHGHGPNRSDTSSDDSQSSASNKEGDTWWSRTAEEGCIIVASSDESVKFHEVWSGTPKNIASTSGVLGGSAILESLEGIEKETEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD18</accession>
    <name>D4DD18_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_05024</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000254">
        <property type="protein sequence ID" value="EFE40268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020886.1">
        <property type="nucleotide sequence ID" value="XM_003020840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD18"/>
    <dbReference type="GeneID" id="9577719"/>
    <dbReference type="KEGG" id="tve:TRV_05024"/>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="16">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="495"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="741"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1049"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE40268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122942" checksum="FEEA6755A45BB9FD" modified="2010-05-18" version="1" fragment="single">IHISVYPVYRLCSRLSCRDLVITTSSPTPTSQPPPPPPPPPASASASASTMPAVAVADSTPAQSAKEAAKSVAVLDELLKSLSLSKSADEAKAAAANIASLLNGPTEEHVVPARAVESLKKQLGNKKDTQAREKALDAILAIAQHSSVSPAMEPYILALLGPTLAAVSDKMNSVKELAQQAALAIVKSINANAVKAALPAIVKSILTAQKWAEKMTGLACIEALVESAPTQLATRVPDLIPVVSESMWDTKPEVKKAAYATMEKVCALISNKDIERFIPELIKCIAKPENVPETVHLLGATTFVTDVHEPTLAIMVPLLDRGLAERETAIKRKSAVIVDNMCKLVEDPQIVAAFLPKLMPALNKNYDTLADPEAREKTKQGLDTLIRVGAVVDGKIPEVSKAGDIETVAAILRELLEPKYKAQIEPAAATIEYIAAIAGQLIDEKVVDVADWTENILAYLTVIVGEEEARSMADNLRKRASPAAAAEAEVEPDEEEGEDLCNCTFNLAYGAKILLNQTHLRLKRGQRYGLLGPNGSGKSTLMRAINNEQVEGFPKKDEVKTVFVEHDLDAADTEQTVIGWTEKKLRDVGITTELSAIQEQLVEFGFVREQLESPITSLSGGWKMKLALARAVFEKPDILLLDEPTNHLDVKNVAWLEQYLVNSPCTSIIVSHDSKFLNNVIQHVILYDRFKLRRYRGDLTALVKRVPSARSYFELGASEMEFKFPEPGFLEGVKTKAKAIVRVNKMSFQYPGTSKPQISDITFQCSLGSRIAVIGPNGAGKSTLVNVLTGELIPTTGEVYQHENIRIAYIKQHAFAHIDNHLDKTPSEYIQWRFATGEDRETMDRANKIVTDEDEKAMDKIYRIDGTQRRVIGIHSRRKFKNSYEYECSFTLGENVGMKNEKWTPMMTADNAWIPRNEILASHAKMVAEVDQKEALASGQFRPLVRKEIETHCSFFGLDAELVSHSRMRGLSGGQRVKVVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKALKSFEGGVIIITHSKEFTENLTNEVWAVVDGKMTPSGHNWVQGQGSGPRLTDKGDDEEEKFDAMGNKIAATKKAKKLTSSELRKKKKDRMARRKRGEEVFSDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD64</accession>
    <name>D4DD64_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020845.1">
        <property type="nucleotide sequence ID" value="XM_003020799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD64"/>
    <dbReference type="GeneID" id="9577584"/>
    <dbReference type="KEGG" id="tve:TRV_05071"/>
    <dbReference type="HOGENOM" id="CLU_393276_0_0_1"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE40227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="692" mass="78700" checksum="BBC02891707828F8" modified="2010-05-18" version="1">MHYGKQQFDSPPASLSEKLQADQELVNWITTLGGGLNPAVEIHRDDKQGSCLRVRSNEALTASTVVARCPISATMSIINVKNLDPNLPSHDFRCSDILSQRVRKSIILAFFMVHEQLKGRDSHWWPYLATLPRASEFTSALFYQDNDLEWLQGTNLYQTHQAYRNAVQEEYDSAISILRDEGFLAVESYRWDIFCWAYTLIASRAFTSRVLDAYFSNHPTLKQDEEFQIMLPLVDSSNHKPLAKIEWRAEATEIGLKVIEPTSSGEEVHNNYGPLNNQQLMTTYGFCIVDNPCDFRDLNVNAPPGTPLANARQFRYQEFHEPHGKSLDNKCFLFNIFYPFSSESSTVEERIFSRDLLDALGLTRLNTRESQNIEVTEERTYANFYDSGSRVVLNALCQGSIELAFRIVRVGRGGYLQKQPSNHKQKLAQTYRETEWLIYMTGLVVCEWAIARARTSDSKELDTLLEKYLSYIPSPTVLERLGHVIKGSKSIVCQPGELFLGIEILELLESSDAKTLVQEFINGISSAVDSLVDPSDRLLSSNTVTYILFLLICLRASKAAVNVSNSPEPFHKTLTDVFSKRLDAYVVQLIDWYPLDDKQTLFENMDEEVEKEIATIFEAIKEEKSRQSYNLLLGASDEWLSADVLRWAVYVVQEEGLTVLRNPLEMISREPSDGPVHMATDSYFYVPQLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDE2</accession>
    <name>D4DDE2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein (Rad57), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000263">
        <property type="protein sequence ID" value="EFE40127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020745.1">
        <property type="nucleotide sequence ID" value="XM_003020699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDE2"/>
    <dbReference type="GeneID" id="9577446"/>
    <dbReference type="KEGG" id="tve:TRV_05153"/>
    <dbReference type="HOGENOM" id="CLU_013059_2_0_1"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="116"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="600" mass="65237" checksum="45017FA7AB335D7F" modified="2010-05-18" version="1">MDLSLTLPDLSTKAYTHLLPLLERAGITLKELLVLDALEIAKASRAPVTDIRKFTAHVLDALHQDLGLGNEPRNNGDNNKTYLLKPGGNGDRSARNETDCSSVVGNGASKVLHPPVTGQISTLDPILDSALSGGISTGYLTEVTGESGAGKTQFLLHLLLSVQLPAPHGLSKNALYISTESDLATNRLSQLINEHQTLQALHPETPRPSLDNIYSVTTVDLESQEHIINYQVPVAISRYNIGIIIIDSITANYRAESSTESVSGLLERSGQLKKLGHFLRTLAVTHNIAVVVANQISDGFESSLHDPFPEESRDYSGSPLEASSPSAVPSFVPASQPYQQPKSAENHLPRGPSVNLPQVNLGTCGQEEDRCSIPGFNLLLSLDYQQQFFTGWAQTPHSYSSGGPLGISKGFKVPALGLIWTNQIGCRIVLKSKSSFQPTSSYPPMLAVQNSNVDMHSTNQDDSTEPVTDPGEKSVVKYNDPDPSGKGQENEVQKAAKHDSTQPLQSSQESFAILEDESWSDYMSVPASQYRGRLRQMVVVFSPWTSGNPEQNSSHGSRNRDTHEEDQLSIKTIFDPMYNSAEFEILPQGLRGLTRSATHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDW5</accession>
    <name>D4DDW5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000276">
        <property type="protein sequence ID" value="EFE39959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020577.1">
        <property type="nucleotide sequence ID" value="XM_003020531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDW5"/>
    <dbReference type="GeneID" id="9577274"/>
    <dbReference type="KEGG" id="tve:TRV_05329"/>
    <dbReference type="HOGENOM" id="CLU_010228_0_1_1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="166"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="708" mass="78120" checksum="9B53DC8B213D4CF0" modified="2010-05-18" version="1">MADHDSRSMSIVPYSGGGDVVLRHDDAIVVFDPNSQQLVLKPANQGVENIGDRTDCPYCHRPLRDGSPEHSQEPHRGPTPATAAPSRFVNPEYFRLLENTIPPSAAADQPPSSPSSPRRQLVPPGREEGTPASGSEHGSGGDGESPSTTHGISSTAFSHDYFKRFFVEERELGRGGKGVVLLVKHILDGVSLGHYACKRVPVGDDHEWLKKVLIEVQLLQHLSHQNLVSYRHVWLENARLSNFGPSVPCAFILQQYCNAGDLQKYICGSIQTAADTPQQLKARLRRRSRGQPELPSAASGPRRLQLEEIYSFFKDITSGLRYLHVNGYIHRDLKPSNCLLHETGLELRVLVSDFGEVQFENTVRNSTGTTGTISFCAPEVLRRVSPGGPFGNFSFKSDVFSLGMTLYFLCFGQLPYRNADVVDEDKEDLDLLRAEISQWAGFDAARRMRPDLPDMLYSFLTRLLDVNPDMRPTAEDVLSGIQTGGSSGRFHRTSPSPTDLQPTARVLPVDSPATGSPSRRSNSPVKRAPPALDLPYAMGHSDALVGGNSSQPISNESEGSVEGRRGGHTNREPTNLLVRSTATSPRIVREYPEGRNRRLYNISNRLLLPPPSRFPILGHILRSRPIIPILMNFTLLTIKIISLTQLCAPLTVKTWIVYPLLFLAVLDLSVPKRWLHVAAFLIHALVLALALKTGSLCAQGFHDLHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE10</accession>
    <name>D4DE10_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000282">
        <property type="protein sequence ID" value="EFE39902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020520.1">
        <property type="nucleotide sequence ID" value="XM_003020474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE10"/>
    <dbReference type="GeneID" id="9584271"/>
    <dbReference type="KEGG" id="tve:TRV_05374"/>
    <dbReference type="HOGENOM" id="CLU_3320325_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="39" mass="4452" checksum="9E13F52BD4D166A4" modified="2010-05-18" version="1">MMMKKKTKMIMMKKTNMMTKIVIVVEESSGCPDQEVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE68</accession>
    <name>D4DE68_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020468.1">
        <property type="nucleotide sequence ID" value="XM_003020422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE68"/>
    <dbReference type="GeneID" id="9584207"/>
    <dbReference type="KEGG" id="tve:TRV_05434"/>
    <dbReference type="HOGENOM" id="CLU_2672892_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="75" mass="7790" checksum="33861F9EF6823733" modified="2010-05-18" version="1">MVKTEVLGRDLKMALMKVTEVGEAGVAGVVVVGAKKEKDGKRERKKDGKKTIGHVESRAAGATSNGRGKGCLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE87</accession>
    <name>D4DE87_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_05454</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="ACYE01000287">
        <property type="protein sequence ID" value="EFE39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020453.1">
        <property type="nucleotide sequence ID" value="XM_003020407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE87"/>
    <dbReference type="GeneID" id="9584192"/>
    <dbReference type="KEGG" id="tve:TRV_05454"/>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="432"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="685" mass="76600" checksum="9D5FFCE1E8A0F1D6" modified="2010-05-18" version="1">MSSNNGIGSSSLSTPSSDPSSTGKTPIPPDTANTVELNTMKPIGVAEAIGLEMDIMQLARLGEIAAIKELFDSGKYDISYRDEEGITPLHWAAINNRFELCKFLLDAGADVNAKGGESVATPAMWAAQRCHHYIVHLLLQYGADPLLTDIQGFNIMHLATIDGNSFLLVLLLHQEIPVDIADPQGHTGLMWAAYKGFPACVDVFLRWGADVNATDEGGLSPLHWALVKGSTACVQKIIEYGADRFAETKEGKTPAIVADEMKTTHIWHHALGECGYEPNGTSSALPSVIGQMLRSSLYMSRFYFLLPFFSLPTIVTILSSLSIYVSILTALLFMFGVHLLIKWVSKRGPLDFRVLQRTVCLLHHDSSQITTDMSLATYSSSLFLNLIFLTLFAFMTYFYTYAMIEDPGFVPRLSSRNEQKAVIMELINDWSYDEDHFCVPCMIRRPLRSKHCRRCKRCVSKQDHHCPWINNCVGNNNFRHFMLYLILLLLGIVAYIRLVFLYYSAIVPGGVKATCNLISPWLCNVVETDTYTFVLTIWTSLQLIWVTMLTLVQLYQISRGTTTFEVMRGHGHGPSHRAPTSPNQAPSTAESNNRSRRSCFTKWKSLFGLDAFMAAAQDGLKDGQSHRRRQNPFSHGIVRNCQDFWCDPAPYFGMRQAGSSMLGGKVVNYYKMYDADILEYSGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEG5</accession>
    <name>D4DEG5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000293">
        <property type="protein sequence ID" value="EFE39796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020414.1">
        <property type="nucleotide sequence ID" value="XM_003020368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEG5"/>
    <dbReference type="GeneID" id="9584153"/>
    <dbReference type="KEGG" id="tve:TRV_05532"/>
    <dbReference type="HOGENOM" id="CLU_3368790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="35" mass="4030" checksum="B962DF397F07E23F" modified="2010-05-18" version="1">MIFFNLEKLSKFLGFSQAKKKKKKKKKVSERAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEK6</accession>
    <name>D4DEK6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000299">
        <property type="protein sequence ID" value="EFE39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020329.1">
        <property type="nucleotide sequence ID" value="XM_003020283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEK6"/>
    <dbReference type="GeneID" id="9584074"/>
    <dbReference type="KEGG" id="tve:TRV_05573"/>
    <dbReference type="HOGENOM" id="CLU_417934_0_0_1"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="682" mass="73970" checksum="6161C93A9E60394A" modified="2010-05-18" version="1">MDAFVGSLPLASANSDAPSSQNREMHQLPHLKIPPLRDPLPPPSRKPPSPLEPNAGTIRESKYNSKSTLAASNQQSELLTVAGFLNNTAQSDKPAVTDPIPSADNPPKTVLPAFINLRAVEKLPYSSFEQEVLPRKRRRVDQYADTFGDHLQLPIPKNQKEVPKQRPPFGPLTILNGLNEPPPNAALFPPIEPNGSLNIPTCGIQQMSTTTNGSSIQNNGGSKPRQHAEDNEKTVGKDRIMGNAASLEIPALTTETQVESQQSFEWANNENDPKDMGETAPKSQRRKKARKWTDEETYDLLRGVVRCGVGNWASILAQSDLNFNDRTSTNLKDRFRVCCSWAYQPDGKPQTLADNTNNRQSGKIFLPDPRKTKGISEPNSLTSSVSTLQNITGNMPPTASKSHTISPFPSGTESSVTSEIPTASHKSHRKARPSARGSDALSKKTKSTLIALGLPDPDATVKANRRSRRPFSQAEDEALLKGYAVHGFQWTLIRQDKHLNLMHRKATDLRDRFRTKFPNAYREGGSATAKIIPLTSNNTTVLSTASDPAEGEKQGPSSTAPASSTTKEHLPRSNFHSPVAESRLGKGNLRRPSNSGTGTKTTACEQNAKTNPSSTPANDIFLSTMTASAMPIDPAMLPPAPPLSTAFTFTTIDDGTSVSASESTLGRSDDVTLPPLVWEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DET9</accession>
    <name>D4DET9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA/TS-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020240.1">
        <property type="nucleotide sequence ID" value="XM_003020194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DET9"/>
    <dbReference type="GeneID" id="9582781"/>
    <dbReference type="KEGG" id="tve:TRV_05679"/>
    <dbReference type="HOGENOM" id="CLU_005723_0_0_1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="896" mass="97079" checksum="35B56AB8DF8501EA" modified="2010-05-18" version="1">MDDLSGLDWSQSSSSQKPAPVNTLSSMSAAALRPTPPMSGRSSPFPPQPTTASNRAPSSKPTTPSNTDSFANLLNFPSGNASKNLSLAERQKQLAEQKAREEREKQEKLKAQYGGVNDQIWDSLEKSGTGQSAPQAQAGVVRGGTTSGGDDEDDLLAAFNASAPVDKSTNFPIPSPSPLSRTDSRSPAGVPTTTVLEDDDDPFGMAEFSASRRQRTEVQATKAQALNGADDDDDVLGLLAKPVSEFPKRETTSPALEVPEEPEAEPSRHTPEDRAIAELVDMGFPIHKAREALAETSSGTDVQQAVGWLLNQAHSEAKEKAQSRNHTGQQERSPDPRVSRRSRREGDGYASSRDRSSNNGTPREKDPAQLASEFGSTLFKSANSLWKTGTKRVQQAVQEFNNGSSDTSSQPRWMRDSTPDPPRSRERKVDTRRESPQGSAQTETMTNEAMMLETSREPPTASSRSRGGEPQGSPHQASSRGRPAELPSRPRFQQEDDLRKQIQRPSHHPQPDTRKQRTLLSRFDADEEASQAYVSPARRRKAASSVPPGFDAPEPDLLQSSSLPARPARPATTSPARQSRTSTPVRPKAPPRTVPQISPASLASIHSHRQKGTEAYKRGDYAVAHASYSSSISLIPNDHPIVIILLTNRALTGLKTGEPKSAISDADRALSIIGPSKGDSETIDLGNGEPPKDMREFFGKALMRKAEALEQLEKWKDASAVWREAIESGHGGNTSIQGRNRCEKAVSIGPNGASSTPSKPISAPSRPKLAPRPAAPKSVSTKPAEAVSRLRAANEAADRIDNEKFHLADAVEAKLAAWKGGKQDNLRALLASLDTVLWPEAGWKKISMAELILPNKVKIQYMKGIAKVHPDKKMISGAVFSTLNEAWDKFKRENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEW0</accession>
    <name>D4DEW0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit Orc5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000312">
        <property type="protein sequence ID" value="EFE39618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020236.1">
        <property type="nucleotide sequence ID" value="XM_003020190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEW0"/>
    <dbReference type="GeneID" id="9584004"/>
    <dbReference type="KEGG" id="tve:TRV_05700"/>
    <dbReference type="HOGENOM" id="CLU_028223_2_0_1"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="256"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="357"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE39618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="556" mass="59869" checksum="D65FE8AE4B400166" modified="2010-05-18" version="1">MLPSDLVVSVSRQWPCREQQARQLAHLLCTPFSPPPAVIVHGPKGSGKSTILKSLLQVYAESQGHRDAKENRSPQAISGAKRQKLGHTSDNEVKGHRFCYAVVNVAECISANHLFMKIISNTLDAMQQGATGRPGDERTNIGSLRCEHVSSLSGLLGSILGKSECRRFVLLLDGIDELREGGQMLLAALCQIGQMLPNASVVFTSKFSPRPLLLHAAGTPHVYFPPYTRAESIAILANLPPPVLPHLSEATAAKLYPPFLSTLYDSLIGPTGGTVSTFQSACEKIWPRFVAPITNDETPPGGVAVEWDFPRLLVRNRSLYQHQGELLLSHRIVSEDFTATFNTPTLATKAAPTLPSLPYLPTLVLTAAFLAAHIPPRLDLSLFSKFTPSVKRRRRRLNTTIQPKASAKADDDPTDDTPKKGGKAASQSKAPKGATNNTSIPGGTRGGRSSYFVNPHSFTLERLLAVYRAIDPNPPLVTDISLADTIFPELATLQRLRLLIPASAGAAAAGGVVDGAEKWCLNINAMVSAGNSISDEWVVEMAHGIGVEVEEYLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF26</accession>
    <name>D4DF26_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_05769</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="ACYE01000327">
        <property type="protein sequence ID" value="EFE39545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020163.1">
        <property type="nucleotide sequence ID" value="XM_003020117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF26"/>
    <dbReference type="GeneID" id="9583935"/>
    <dbReference type="KEGG" id="tve:TRV_05769"/>
    <dbReference type="HOGENOM" id="CLU_035731_0_1_1"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="301" mass="32477" checksum="4A6C6B47F7B363C1" modified="2010-05-18" version="1">MLMYPLFITDRPDEQIPVPSLPNQYQIGLNKLIPFLKPLIKKGLRSVILFGVPLAPGAKDALGTMADDPSGPVIQAIRLLRSTFPSLYITADVCMCEYTSHGHCGILREDGSLNNTLSVERLSDIAVAYAQAGAHCVAPSDMNDGRVRAIKLKLIEAGISHQVVLMSYAAKFSGCLYGPFRDAAGSSPSFGDRKCYQLPPSGRGLARRAIQRDINEGADIIMVKPAGAYLDIISDAKELGRDLPVAAYQVSGEYAMIHAGAKAGVFELKAMVMESMQGILRAGGSIVTTYFVPELLDWLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF42</accession>
    <name>D4DF42_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000330">
        <property type="protein sequence ID" value="EFE39528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020146.1">
        <property type="nucleotide sequence ID" value="XM_003020100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9583921"/>
    <dbReference type="KEGG" id="tve:TRV_05787"/>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2609"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1769"/>
            <end position="1782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="2839" mass="327771" checksum="36F7A05B794122E1" modified="2010-05-18" version="1">MASLPPPPPPGWGAAPPPSMPLAPPPPGYRPAPNPMLAKFEQKKKEWLRSQRNRFGEKRKAGFVQSQKDDMPPEHLRKIVKDIGDVSQKKFSTDKRSYLGALKFMPHAVLKLLENMPMPWESAREVKVLYHVNGCLTLVNETPRVIEPVFHAQWAAMWVCMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDEAEDSPVFEWFYDHRPLLDTPHVNGPSYKEWNLTLPQMATLYRLSHQLLSDVVDKNYFHMFELNSFLTAKALNVAIPGGPRFEPLYKDIDPNDEDFGEFNAIDRIIFRAPIRTEYRVAFPYLYNSLPRSVKISWYSHPQGVYVRTEDHNLPAFYFDPIINPISSRSVAPQNITVSHEDEIFGHGNDEDDFELPAAVEPFLADEELYTSETSSAISLWWAPYPFDRRSGRMVRAQDVPLVKQWYLEHCPQGQPVKVRVSYQKLLKTYVLNELHKRKPKAQNKQNLLRTLKGTKFFQQTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNSGSVGKGPGCGFWAPAWRVWLFFLRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIKQNKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKSKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYMKDGPYVSSEEAVAIYTTTVHWLESRKFSPIPFPSVSYKHDTKILILALERLREAYSVKGRLNQSQREELALIEQAYDSPGTTLARIKRFLLTQRAFKEVGIDMNDNYSHINPVYDIEPIEKITDAYLDQYLWYQADQRHLFPAWIKPSDSEVPPLLTYKWAQGINNLSNVWETADGECNVMIETQLSKVYEKIDLTLLNRLLRLIMDHNLADYITSKNNVQLNYKDMNHTNSYGLIRGLQFSGFVFQYYGLVIDLLLLGLQRASEIAGPPQSPNDFLQFRDRATESKHPIRLYTRYIDKIWVFFRFSADESRDLIQRFLTEQPDPNFENVIGYRNKKCWPRDSRMRLMRHDVNLGRAVFWDLKNRLPRSITTIEWDDTFASVYSKDNPNLLFSMCGFEVRILPKIRNQNEEFSVKDSVWSLSDNTTKERTAYAFLQVTEEDIQKFNNRIRQILMSSGSTTFTKIANKWNTSLIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPTSDKRWSKQTDTGVTHYRAGMSHDEETLIPNIFRYIIPWEAEFIDSQRVWMEYSQKRQEANQQNRRLTLEDLEDSWDRGLPRINTLFQKDRSTLSFDKGFRARTEFKIYQLMKSNPFWWTSQRHDGKLWNLNAYRTDVIQALGGVETILEHTLFKATAFPSWEGLFWERACLAKGTMLLRYDHSQVAVEDVKEGDLLLGPDGGPRRAFNIVSGEDRLYRIKFGDRKDDLVVTANHILVLHKEKSRTDEYEANIDPLEKDAEEFVVAPASQEAPTPERYETVEMTAAEFYALKHEERCKYMLFNSPGFDLAEQSVPCNPYFLGLWLGDEKRRSAPIHDYSHEADVRGFLVRHAAELDLHGQLGLQTTEAPRTNAEGHTPRQSIISRRLAAGWTFQTGIWEPPTENPTYRGVSSQARPDDKPMGLIKDPETVKKGDLDSYLDILGTVNETDDSQLDGNLPQTQRSVRLQTGLSAYGTLQEEEQDQLLEQVTGKSQGNPGVNSLLQALRGVGVIAEPESIGPKDGRKRIPAVYINNSRAVRLAVLAGLLDSDGWLIYPENMFGFSQSEQCNSALFWDTVALARSLGFSVSTTRRMMWNSTHAMQRPQLFAEISGNLKEIPCLLSRKMAMDLVIPQNYSFIIKDITLEREITGWAGFRVDKDQLYLRHDYLVLHNSGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEQLGIETVQKETIHPRKSYKMNSSCADILLFATHKWNVTRPSLLFDTKDVIEATTTNKFWLDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSIYPSATGLMIGIDLAYNLYSAYGQYFPGLKALIQQAMAKIMKANPALYVLRERIRKGLQLYASESNQEFLNSQNYSELFSNQIQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKIEKLADMILKATEPQMVLFNLYDEWLKTISSYTAFSRLVLILRALHVNIEKTKILLRPDKTVITQEHHIWPTLSDEDWIKLEVQLRDLILNDYGKKNNVNVQSLTGSEVRDIILGMEISAPSLQRQQAAEMEKQQQEQKQLTAVTTKTQNVRGEEIIVTTTSQYEQQSFASKTEWRTRAIATSNLRTRANNIYISSEDIQEDGHFTYIMPKNILKRFIMISDLRVQVAGYLYGSSPPDNDQVKEIRTIVMIPQVGNTRDIQLPQQLPQHEYLNGLEPLGIIHTLSGNEPTYMTAMDVTQHSRLMNAHSSWDKKTVTMTVSFTPGSVSLSAWALTPQGYKWGAENKDTTSDQPQGFSTNMGDKCQLLLSDRIRGYFLVPENNVWNYSFMGSSFSSVEKRPIYVKVDTPMVSSPSLLLQFTIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA2</accession>
    <name>D4DFA2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020075.1">
        <property type="nucleotide sequence ID" value="XM_003020029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA2"/>
    <dbReference type="GeneID" id="9583839"/>
    <dbReference type="KEGG" id="tve:TRV_05848"/>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26044" checksum="82F3DEB2A6808A34" modified="2010-05-18" version="1">MSQSHALSDDQVAGELRKMTAFIRQEALEKAREINLKADEEFAIEKSKLVRQEIASIDQLYEKKFKQASMSQQITKSTLANKTRLRVLSARQQLLDELFERARGEVTTAATGKKGANYEKTLAGLILEGLYALNESKVQVRARKADYAAVRKAAENASKEFKDKVGREATVEIDEREPLAQDSAGGVIVLGSNGKIEYNNTLEERLRLLEADSLPTVREMLFGKNANRKFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA7</accession>
    <name>D4DFA7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020080.1">
        <property type="nucleotide sequence ID" value="XM_003020034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA7"/>
    <dbReference type="GeneID" id="9583844"/>
    <dbReference type="KEGG" id="tve:TRV_05853"/>
    <dbReference type="HOGENOM" id="CLU_022271_1_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="273" mass="31282" checksum="4530E0F25F637E42" modified="2010-05-18" version="1">MQFDRVLFLNDVYFSAIEAAQLLFSTNVDQAGHAQYRAACAVDFISKAMFYDTFVVRDAEGYGTGLMFFPWFAPVGRARSRNQVLQGADAVEVRSCWGGMAAFQASVFQHFSTADSTSHIVTRFRHDSEPFWESSECCLIFADWEDRFGRPDVANRTGVFLNPYVRVAYSQNTWKWLGFFRRFERVFANLQYLVSRLAYPEHNPRRTHLPGQKVRERVWQSNADGQPGGSLQTIQRIASPGGFCGQRRMFIMVDDIEKANRNGAKNWKKIPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFY5</accession>
    <name>D4DFY5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase subdomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019890.1">
        <property type="nucleotide sequence ID" value="XM_003019844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFY5"/>
    <dbReference type="GeneID" id="9584641"/>
    <dbReference type="KEGG" id="tve:TRV_06088"/>
    <dbReference type="HOGENOM" id="CLU_350621_0_0_1"/>
    <dbReference type="OrthoDB" id="5401902at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="89646" checksum="F4699FB68AE36495" modified="2010-05-18" version="1">MATVLAQSPGSSSIFREAVNSGNEGKEKPRLKVYEDLEPGKGDLSLSSTVKMKPRKYDIETLLSIGKNMGKTDFPKRLNLSSFYGSGRKSLGSGSYVLREKPVNHTRTSTDMSMDSDASYHTTQSSHFQFPCRQPKNAPEGNIAQTNEGFARFLKEHASPKHHRVTAGGRIVPMTLRASPTPEFKPAVKGVEPACNQNPCQNPGASHSPMSGKGDESKEDTGTMRRHRTRTMAEHTTRSEQGRRRDSAMSQASKGNTTKTTPRYQTPVISAPVTSNPTTPGQMGGINFIPNLVNVGMDGLSMQQGQTDQGAFPFPSLQTYYSPAGIAQTVPDQAHGAAQAQFIGPACNIIPYPTPPGLGMINLAQMYQLPGAFNSFTGYMAPGLNAAQTASQPNDSRGLSNMLDNAIQEFETISAQLSNLDRYMAVHTWDIDPSSKKILVIQRMELVTKLDAARVLKENIEAMLRSSNDSAMPVKVHQKGPNPGSHDFITAPPCTPVMTPQGGYYNPGLTNAGGSSFSMSDVHGFMSPVQATESPYMSPESYCDNGFLANMPASSATSNNWTVPGVNNMGIPERLADDDDEDDMRIITSATGQKIGEPTRNARAPPELSVIYQKIEQAAKRNEPLGPLFQELAKVTAHITRLGTNRGRNPDTFGSGRIGVPRGRPSARLEIVDPKARQAAAPQTPKPVQTPIATTGSSKEPAQFKKLSKLQQSPLSFSPCKQHCRKHDSKKVETLTMEQKVNAHGYLPPFDGGGDAPGRASQTEPNKIEAAKPTAPSTENTWMDLLRTRPNANPMDVRRFFKLLRDEDSAALDKYRKEGDRRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGD7</accession>
    <name>D4DGD7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000352">
        <property type="protein sequence ID" value="EFE39102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025837.1">
        <property type="nucleotide sequence ID" value="XM_003025791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGD7"/>
    <dbReference type="GeneID" id="9583647"/>
    <dbReference type="KEGG" id="tve:TRV_06240"/>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="43893" checksum="241B986BB262E867" modified="2010-05-18" version="1">MFGLALGVAKLDQNLPTIVYAFLSGLNASTVGIIALAAVQLAEKSIQDKVTRILVIFGGSAGLCYQAIWYFPILILIGGCTTAVWDLIAQPYITKLRDKLRQRRSSSSGDAEAGIDHVGVQLNHPHQSLALQRRRVLAGRAQEPQADLPQLRRSDSSTIIPDSPSTLVGSDSNQPMDTHSHSLHMKWGILIIVLFFASFVAILVVREGMEKPMLDLDLFSNLYLAGTVIFGGGPVVIPLLREYVVGPGWVSPRDFLIGLALIQAFPGPNFNFAVYLGGLAVASMHSPTILGSAMAFVAIYIPGMALAVGFQSCWSVLRKYPLTTSCLRGMNSAAVGLVFTAVYRLWEIGYLSANASQGQSLGMEPFWVVVAAITYAENAWFRVPPAIAIAIGGILGLCWYAVVQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGL6</accession>
    <name>D4DGL6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000360">
        <property type="protein sequence ID" value="EFE39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019649.1">
        <property type="nucleotide sequence ID" value="XM_003019603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGL6"/>
    <dbReference type="GeneID" id="9583549"/>
    <dbReference type="KEGG" id="tve:TRV_06321"/>
    <dbReference type="HOGENOM" id="CLU_2442470_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="90" mass="9330" checksum="CBE06FC123D547D8" modified="2010-05-18" version="1">MARGEEEDSTCAEREHAMNIVAASSSGEGRSAAAAAAGGGGGGGGGAGRASSTSRQRRKKRKRTTRWTRKQEVRRGTKQKAKGKKRASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP4</accession>
    <name>D4DGP4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_06349</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019631.1">
        <property type="nucleotide sequence ID" value="XM_003019585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP4"/>
    <dbReference type="GeneID" id="9580161"/>
    <dbReference type="KEGG" id="tve:TRV_06349"/>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="403"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="403"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="536"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="581"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="673"/>
            <end position="676"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="778" mass="85294" checksum="0998423AD4B321E5" modified="2010-05-18" version="1">MAAPTPVAAPAKQRRIAVLTSGGDAPGMNGAVRAVIRMSIHCGCEAYAVHEGYDGLVQGGDYFRQMFWEDVRGWLSRGGTLIGSARCKAFREREGRLKAAKNMVIRGIDALIVCGGDGSLTGADIFRSEWPGLLEELVKNGELSSKQIEPFKSLNIVGLVGSIDNDMSLTDATIGCYSSLHRICEAVDEVFDTASSHQRGFVIEVMGRHCGWLALMSAISTGADWLFIPEMPPRDGWEDDMCDIITQNRRRGKRRTIVIIAEGAQDSHLEKITSNKVKDILSDRLQLDTRVTVLGHTQRGGAACAYDRWLATLQGIEAVKAVLEAKPGSPSPIITIRENKIERTSLVEAVRVTKSVSEAIAKKDFATAMALRDSEFMALHRAYINTTTPHHPKLLLPEAKRMRIAIIHVGAPAGGMNPATRGAVAYCLARGHTPIGIYNGFPGLCRHHDDKPLGSVREVKWLESDSWVNEGGSEIGTNRGLPSEDMETTAKCFELYKFDALFVIGGFEAFTAVSQLRKARKDYDAFKIPMIQLPATISNNVPGTEYSLGSDTCLNTLVNFCDVIRQSASSSRRRVFVIETQGGRSGYIATIAGLSVGAYAVYIPEEGISIKMLANDIENLRKSFATDRGANHAGKIILRNERASATYTTQVIADMIKEEAKGRFESRSAVPGHFQQGGKPSPMDRIRALRMSLKCIQHFEEYADKSPDEIAADDMSTVVIGIRGSEVVFSPLGGKDGLEATDTDWEHRRPKNEFWLKFREMVDTLSGRPDGNYKTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGP6</accession>
    <name>D4DGP6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_06351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019633.1">
        <property type="nucleotide sequence ID" value="XM_003019587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGP6"/>
    <dbReference type="GeneID" id="9580163"/>
    <dbReference type="KEGG" id="tve:TRV_06351"/>
    <dbReference type="HOGENOM" id="CLU_031816_1_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056262" description="IMP-specific 5'-nucleotidase 1" evidence="13">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="426" mass="47692" checksum="BB58989655F14CE1" modified="2010-05-18" version="1">MAGLFHCILYFAGIIEFACLTVISSQSHRRDQLGLLAVPFVLHSQPTAAYKENSPNLAHLAERTHNRYVEIMRDVEHLINDHIELQKTGASGKSTLKLLVPSVGTFFTPLLLEDAFIYQDNKRFISHRRFVPPSFNDIRLTLNTAQLMGLVRRSEVQLITFDGDVTLYDDGCSLTADNPVVKRIILLLKQNKRVGIVTAAGYSSAAKYKERLEGLLEAIKDSADLSVKQKNHLTVLGGESNFMYEFDPQSPDLLTYKPQSEWQLDEMKQWNDEDIKELLDIAEAALRDCVSNLRLPAAILRKERAVGIYPLEGHRMHREQLEETVLVAQQTIETSEVGRRLPFCAFNGGSDVFVDIGDKSWGVLACQKYFGGIDRSKTLHIGDQFLSAGANDFKARLACTTAWISNPGETVQLLDELAVLEQGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH76</accession>
    <name>D4DH76_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019451.1">
        <property type="nucleotide sequence ID" value="XM_003019405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH76"/>
    <dbReference type="GeneID" id="9577901"/>
    <dbReference type="KEGG" id="tve:TRV_06531"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="511" mass="58856" checksum="A4B82B9D44426EF1" modified="2010-05-18" version="1">MLLMEPVSMLTTALVALLGYFIVQTIYRLYFHPLSKFPGPKIAAAGRFYEFYFDIVKGGMYIWEIQRMHEQYGPIVRVNHRELHIKDPDYYAEVYSSRKQEKDFHAVSAYGMTHSMITTLDHDHHRFRRGLLNSFFSKRAVTSLEPMVLEKVNRAAERIEEAFNQNELVPFDKVFAAVTADIISKYSYGQSVDYLENKDYQNDFRDFGNVASNLSHIFTFLPGMMGVVKVIPEAWLQAVQPQAVGFFSMRNLVRDQSLAMLKETHRPGYKSPDGADRNIFHALCDPAVPDKEKEIERLTEEGLGVLAAGTETTARTLTVGTYYLYHDESVLHKLRQELKEVMPKPDSPITWAQLEKLPYLNGVINESLRLSHTLVMRLPRIAKDQSLAYGEYVIPPGTPVSMISYFIHLDPKIFPDPQRFDPERWIRATEKGERLSRYNVSFTKGNRICLGMNLAYIELYHMFATMVRRFDMDLHNTTFDNIRVDREFGPGLPEGKNVIEGYAKVTTVLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH81</accession>
    <name>D4DH81_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000373">
        <property type="protein sequence ID" value="EFE38811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019456.1">
        <property type="nucleotide sequence ID" value="XM_003019410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH81"/>
    <dbReference type="GeneID" id="9577906"/>
    <dbReference type="KEGG" id="tve:TRV_06536"/>
    <dbReference type="HOGENOM" id="CLU_1262332_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="219" mass="23814" checksum="917CC9BE9E4DC105" modified="2010-05-18" version="1">MLAGQLLVGCCEIYLADKEDGRRPVEGCPASSTAIWNPETANPPSISLSISVHPVYPVYLMVICACQPARLFPACDFKRASHSSSSSFSFPSSSSPSSSSSRLCDFCVFSSSLPLCPHASNYITNQLLHQTPQLHPTSPQTELEEKRLKSREQRKMAPGIDTSHQPRERRPSVGAPHSDLQGPVGPGFSRPKHKRTFTGFGPKDIKSVEASIPEPQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHC6</accession>
    <name>D4DHC6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein Pex17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000377">
        <property type="protein sequence ID" value="EFE38770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019415.1">
        <property type="nucleotide sequence ID" value="XM_003019369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHC6"/>
    <dbReference type="GeneID" id="9580131"/>
    <dbReference type="KEGG" id="tve:TRV_06582"/>
    <dbReference type="HOGENOM" id="CLU_016177_0_0_1"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="68858" checksum="850EEE919AF672F5" modified="2010-05-18" version="1">MLSVFNTAAVTIVNYESAYDPHSPNLQRRGIGREDWAKAVVNGADEKSPRWRHLLLLGGLLLGFEGQNRRGLSYALRKKLEAALVTGIQLALDELRSSPAIAAYTIVLVLNYTFELLSDWERSRINYDVLLPVLADAAFMSPEGLESGYFLGSIDRGIEEIPGQGKFCWKEDSPSYYQAKDILMRPLVASFGPLSRLIAHAVENTSNCGQVIQVLDSLFELSRTLMVQWRQNKLSEIDQSEESEFLDTASLQTTVPTLWKLLNIPLFSFIIVLRAILGRVLNDPILAADRSSPFIASKSLKSLRHLAFITARAGYSSSSQYVFVNLTAIDILAQYPDLSEDFLEEIRPSDSSKIPAHPLDRCLDLFFLNTAEHFSLIVSPMLNERLLLSAAQPYLAAGGNNHLLEIFESAHSVVLAVLAAPQSANMAAKHLPSYVDTLFTVFPQNLSARQFRLAFKTILKITAPPSPLANSQPYLPSVLLQLLYDRAISAPTTPLLPPATDSNPNPAPEDLSEQGVLTITIIDGLPYLRVELLEDWLDLTVDLINRIHDQEIRRKCQEKFWDTSSNGDMDVERANFCVTWWSTRSGRDMLLRKSEEEDTQLYSMSGGVAMQLIQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ0</accession>
    <name>D4DHJ0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019302.1">
        <property type="nucleotide sequence ID" value="XM_003019256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ0"/>
    <dbReference type="GeneID" id="9577624"/>
    <dbReference type="KEGG" id="tve:TRV_06646"/>
    <dbReference type="HOGENOM" id="CLU_1918591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="132" mass="15004" checksum="76EEEF8239E7CB64" modified="2010-05-18" version="1">MKRRRCAMMDDDGWMGRRERHEKARRSQRPTISLSLSLSPQLDASREWPGHVLRWLAAPYLPAIKEALHRRNSQQLREKVEQRADGSLAFIHRWLSTTDDDVSAAWKPGKQGLSEASAACHDADSVTTAVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHX9</accession>
    <name>D4DHX9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019180.1">
        <property type="nucleotide sequence ID" value="XM_003019134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHX9"/>
    <dbReference type="GeneID" id="9577177"/>
    <dbReference type="KEGG" id="tve:TRV_06786"/>
    <dbReference type="HOGENOM" id="CLU_036731_0_0_1"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52642" checksum="ED6D3E2B43F387FC" modified="2010-05-18" version="1">MSTSSLQKRHVGGLTSLDYISTLLFLFLVSKRQKEEAKLANNNNNNNKLASTRRRRRRLREERDYASLCSIKTLVTLTTDLGDSFLAEEVELRASVLRVDSDNDSRKNDRHTVQCIKQKNFIWPAASRQLLIAIDGLQLDLRRHAVQLHVGPADRGHQPGPDDDFAVSSAIPTVISAWSPPFGGSESPQADKLALRWLRTRCPAEVRIWEETGNNLARHIWYDFEDSIINYQPPFFPCIHSSSFLCIIYSMALSNLYRDASLAWLMLFQETLSPVVVAADGDDGKATSPFLMFKDLIRQNDNKSHFNVIELGAGCGIVGIALAQSLTDCSVLLTDLEEVRDIVSRNINMSYPAAGSKIDFQVLDWEASVPSRISGQQYDLIVVSDCTYNSDSLPALVDTMAALVERSPKAAIIVALKRRHESEAVFFELMHRARLDVCSKTHIQLPSVCSDERVDIEIHCFRSSPFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIM9</accession>
    <name>D4DIM9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019026.1">
        <property type="nucleotide sequence ID" value="XM_003018980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIM9"/>
    <dbReference type="GeneID" id="9582431"/>
    <dbReference type="KEGG" id="tve:TRV_07039"/>
    <dbReference type="HOGENOM" id="CLU_137480_1_0_1"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="114" mass="12534" checksum="EA96C786CC44C38D" modified="2010-05-18" version="1">MARGNVGVYKVFYKGETDDFVVYVDDVASVKQWRKDKTVPLAQVVSGWKIFITHRHGAQGIHDGASKATLSNEFGTSDEVECITKILEKGDLQESENTERNGSTNDSKGGLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIN6</accession>
    <name>D4DIN6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_07046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018914.1">
        <property type="nucleotide sequence ID" value="XM_003018868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIN6"/>
    <dbReference type="GeneID" id="9582073"/>
    <dbReference type="KEGG" id="tve:TRV_07046"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="438" mass="48172" checksum="677EB0871C3FC039" modified="2010-05-18" version="1">MSTLQRSLNVLLRTGKYAAQRPSAVNPMQYVFSHNRMSARGMVAAFERNKPHVNIGTIGHVDHGKTTLTAAITKRQAEKGFANFLDYGSIDKAPEERKRGITISSAHIEYQTDKRHYAHVDCPGHADYIKNMITGAASMDGAVVVVAASDGQMPQTREHLLLARQVGVQKLVVFVNKVDAVEDPEMLELVELEMRELLSHYGFEGEETPIIFGSALCALESRRPELGVEKIDELLNAVDTWIPTPERATDKPFLMSIEEVFSISGRGTVVSGRVERGILKKDSDVEIVGGSTTPIKTKVTDIETFKKSCDESRAGDNSGLLLRGIKREDLKRGMVVAAPGSTKAHTDFMVSLYVLTEAEGGRSNGFTHKYRPQMFIRTADEAASFSWPGEDQDKKAMPGDNVEMICKTLHPIAAEAGQRFNIREGGRTVATGLITRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIP0</accession>
    <name>D4DIP0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor eIF4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_07050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018918.1">
        <property type="nucleotide sequence ID" value="XM_003018872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIP0"/>
    <dbReference type="GeneID" id="9582077"/>
    <dbReference type="KEGG" id="tve:TRV_07050"/>
    <dbReference type="HOGENOM" id="CLU_043552_5_0_1"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE38273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26925" checksum="10C7258498D29E3E" modified="2010-05-18" version="1">MTIQPPKFTALEPVTEDEVQALNPTRKTLHQNIIGKLRPLPFQYRWAVWHEKHSESTNYGDRLYPLHDDVADIATFYRIYNNYPWGKIKVRDTVHIFRRETKPVWEDPQNLKGGCWTFRVPKSKSQAFFHEVAILCMANEFQAAVQSERDHVLGVSTSARFNSNLISVWNKQGYNLKAIKALEEVILQRLSPELRPTAEKSYFYKRHDEHDGYQAAIEAALGSATHRSNTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIS3</accession>
    <name>D4DIS3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000412">
        <property type="protein sequence ID" value="EFE38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018892.1">
        <property type="nucleotide sequence ID" value="XM_003018846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIS3"/>
    <dbReference type="GeneID" id="9580063"/>
    <dbReference type="KEGG" id="tve:TRV_07084"/>
    <dbReference type="HOGENOM" id="CLU_068909_0_0_1"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38191" checksum="D35D8AC7C21D154D" modified="2010-05-18" version="1">MSFLNSVLSSIETGEVSITPPPPPKSTTPDSTSSNQKPSLNSKLAATSISGNSNGYTGTAQKRKAGEQLTRPAPRNDRFSKPASSSSPQPATPASRLPRDSDAARKPASKPTSSATAAPKPALSKPSATPVSTKPPPKGSYAAIMAEAKALQNKAPAAVGLIKHQAVPKDKKSKVQQKKMTEEAKQRDREPANRKLSTEKSAVTAPSRSTKEAILKARQAEMGKQEAYKGTARPRPGSLPPARSSELSYSGTAGLPSRRAQGRDASYGRSKSRGAARNEYLGTDEEDEGDYGYGDEDDYSDESDMEAGFLDVEEEEQTALRIAKQEDAEELRLEMAAKKEKMERKMKLNALAKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJE0</accession>
    <name>D4DJE0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_07306</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000436">
        <property type="protein sequence ID" value="EFE38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018674.1">
        <property type="nucleotide sequence ID" value="XM_003018628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJE0"/>
    <dbReference type="GeneID" id="9580827"/>
    <dbReference type="KEGG" id="tve:TRV_07306"/>
    <dbReference type="HOGENOM" id="CLU_015741_1_2_1"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="329"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="423" mass="48920" checksum="A3F3233AFB4D2E32" modified="2010-05-18" version="1">MAPVVVDREFPNAMFISIRRTDILFNFLGAKRKASEEATTPDSKANIKKARTESPETHDQEETDAEKVKLVPYAEKPAVLEEREGKIEFRVVNNDSSRESFIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKHPLEVVGGITYRPFHGRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEISLEKSIWMGYIKDYEGGTIMQCSMLPKIRYLEAGRMVLKQKEAVYAKIRAFSKSHIVHQPPKEWKNGVVEIDPLSIPAIKESGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFAQPVNRDEVPDYYEVITEPMDLSTMEEKHEKDMYPTPQDFIKDAKLIFDNCRKYNNESTPYAKSANKLEKFMWQQIRNIPEWSVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJG7</accession>
    <name>D4DJG7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RSC complex subunit (RSC1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_07333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018645.1">
        <property type="nucleotide sequence ID" value="XM_003018599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJG7"/>
    <dbReference type="GeneID" id="9580796"/>
    <dbReference type="KEGG" id="tve:TRV_07333"/>
    <dbReference type="HOGENOM" id="CLU_007728_0_0_1"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
        <property type="entry name" value="Bromo_Rsc1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000015">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="381"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="867"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE38000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="103045" checksum="D73444AE107F3079" modified="2010-05-18" version="1">MAEDSSGGAASIENQLREAAQEPAAETPGVVESIESSKAADAPASQVTLVQWRAMSDVLISLYNYREPDGHDPSRLFHRSVNKRNVPDYYDVIKEPMALSVLKQKIKSKVYTHFAEFVRDCALIPHNAQTYNRPKSMAYEDALIIKDVMISEFQKLAEQEIISPETAQLPDLGEIPEADPLPAEEEEEEEEEDEEDEEAEDSDDEAPRRKRKGRPRLSSKRESGVNDLHKGADADGRKRRGRPPRVDTPMEARIKAVLKGIRKLKDSSGQMKVRHFERLPDKSAYPDYYVEIKEPLAIDLIKRKSKRKKYTSVDHFMRDVDVMFNNAKAYNLPESQIYRDAVDLHREAHRLAEQEKNKADSEYLMEDGRLPLPNGITYKDEVWRVGDWVHLQNPNDATKPIVAQLYRTWQDPEGEKWINACWYYRPEQTVHHFEKHFYPNEVVKTGQYRDHRIDEVVDRCFVMFFTRYNRGRPRDLPLNKEVYVCEARYNEEKHKLNKIKTWASCLPDEVREKDYEMELFDAPRKIKKIPSPIRHLLKEDAKETDDLPKPTWGAENAPPIVGAVHCRPRDENESPPPEPTPSPPPPQLQPPASLPIPRPPSMVQPHTPMQPMPGQDHVRHNSIPHIPGRMPHAAHLATSPQPPMMPGGPHPYHPARPNMPMYPVAHNNRNMPVHPQTPQPPYHAPQPAQPYSAPHNFPSYQGSRLPQASIPPPVYNPNAPRSVETFHLRDGLDQSIPKEIRDQFQQDDQGRVLFFNVPPLDVVSNSHQGLSHSLKYLAAKERRLKLIEATRKRISASSEESQTKKQKIEAEAAAEKKRLEDKENLHAETLKMITQTITRSNSEFYMYHYGDRAAEVMERDLQAHLDRCYPKSPKPKEPELVLRPSAPKLRWNPKGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJI0</accession>
    <name>D4DJI0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">TRV_07348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018658.1">
        <property type="nucleotide sequence ID" value="XM_003018612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJI0"/>
    <dbReference type="GeneID" id="9580811"/>
    <dbReference type="KEGG" id="tve:TRV_07348"/>
    <dbReference type="HOGENOM" id="CLU_071892_0_1_1"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="239" mass="26621" checksum="2E841415A39F7971" modified="2010-05-18" version="1">MAGLVSRVRPACRRCLSSAQPTYRIQARYSSSSSSSSNKDNDNGGRKMMELSESQKAYLSSALRVNHAGELAATLIYAAQSPPVLRSHPHLRPLMKHMYDQEAGHFSVFTEMLASHRVRPTAMYPVWQAAATFLGWSTGVMGREAAMACTEAVETEIGTHYNDQIRVLAGWMEDAEARGEVVPDELKQLVQTLKRIRDEELEHLDHAVENDAKEARPYEPLIGVIRLGCRAAIQISQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJU0</accession>
    <name>D4DJU0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_07458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000445">
        <property type="protein sequence ID" value="EFE37867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018512.1">
        <property type="nucleotide sequence ID" value="XM_003018466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJU0"/>
    <dbReference type="GeneID" id="9584441"/>
    <dbReference type="KEGG" id="tve:TRV_07458"/>
    <dbReference type="HOGENOM" id="CLU_050914_0_0_1"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE37867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="38127" checksum="A6BD3946263025E3" modified="2010-05-18" version="1">MDSFANQPGGGRASRSAVALPRLQDQAEQGRPPRQAAPKMQRQMLTDVVVVLREQLLAAHLTNASHTAPPPPRPQPGVPAHLQAAAAAAGAGGQRDHIIDPAISGMTAAPQVHTTAAMLAQPPQAQVPVGQQDMTGAPPGLDQTGEPRKVYGKRELSSSKRAAQNRAAQRAFRQRKEGYIRKLEEQVKEYEMLLDNYKAIQAENYQLREYIISLQSRLIDSQNEVPELPGNIDLSQPRPEPAIVTSGGQQQGQQGQQGQAQQGQQGQQQAGQQQGQQQGQQGHQQGGAGGQAGAGQHSSQSELNALNRIAVAGLGMRKHQHEEAAFLGQGGNFSKRTRQDGQDDSQAGEQSKAEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJZ3</accession>
    <name>D4DJZ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_07502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018488.1">
        <property type="nucleotide sequence ID" value="XM_003018442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJZ3"/>
    <dbReference type="GeneID" id="9584417"/>
    <dbReference type="KEGG" id="tve:TRV_07502"/>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="77"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="416" mass="45532" checksum="AF0A9F5C41390C16" modified="2010-05-18" version="1">MSDYEDDMDVDAPPARDTAAFTADPTDVKGKRIVADLPVEAGDNLPWVEKYRPDTLDDVSGHQDIIATINRFVDSNRLPHLLLYGPPGTGKTSTILALARRIYGSKNMRQMVLELNASDDRGIDVVREQIKTFASTSLVYKGRSEAESLTAIVGTKQIFSTAPSSGSGLGAFKLIILDEADAMTSAAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKEKDIRRLVDTVIETEEVQIQPDAIDSLVKLSKGDMRRALNVLQACHASSMPLPSKNDDANEQQQERETITEETIYTCIAAPHPADIKIILETLLSTSDVTSCLNTVQTLKANKGLALADIISALSTELQSLEVPAQVRVSWIEGLADVEWRLSGGGSEVIQTGGMIGVIRSGCELMGDKDILMNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL57</accession>
    <name>MCPA_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName>Probable metallocarboxypeptidase A</fullName>
            <shortName>MCPA</shortName>
            <ecNumber>3.4.17.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase M14A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MCPA</name>
        <name type="ORF">TRV_07931</name>
    </gene>
    <organism>
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-"/>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018043.1">
        <property type="nucleotide sequence ID" value="XM_003017997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL57"/>
    <dbReference type="SMR" id="D4DL57"/>
    <dbReference type="MEROPS" id="M14.014"/>
    <dbReference type="GeneID" id="9579170"/>
    <dbReference type="KEGG" id="tve:TRV_07931"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_1_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000397760" description="Activation peptide" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397761" description="Probable metallocarboxypeptidase A">
        <location>
            <begin position="113"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="3">
        <location>
            <begin position="119"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="422" mass="47132" checksum="7BF1DC86643A9FC4" modified="2010-05-18" version="1" precursor="true">MRSVLSLALLAVNVVTAAVVAPFDYSGYKVIRVPTQKDNVKEVQRIITDLNLDTWKYPKSEGQNADIVVPPSQISSFMERISGMNIEMMHEDLGLSIRNETSFEAYSAGYAPDINWFKSYHSYQDHLSYLQDLQGLFRTRSEYVDAGKSHEGRTIPALHIWGSGGKNSKPAIIFHGTIHAREWITTMVTEYMAWSFLSQYNKNADITSIVDNFDIWIFPIVNPDGFAFTQTSNRLWRKNRQPNPNARCPGRDLNRNYPYQWVGPGSSSNPCSDTYRGAQPGDGTEIKVHIANMKKIAANKGIAMFVDWHSYGQLFMSPYGYSCTARPPTDARHQELSRIFAQALKAVHGTPYKTGPICNTIYQVNGDSVDYALEVLKVKLSLTAELRDTGARGFVLPADQIIPSGEETLAGTVAMLKAVIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL58</accession>
    <name>D4DL58_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_07932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000493">
        <property type="protein sequence ID" value="EFE37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018044.1">
        <property type="nucleotide sequence ID" value="XM_003017998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL58"/>
    <dbReference type="GeneID" id="9579171"/>
    <dbReference type="KEGG" id="tve:TRV_07932"/>
    <dbReference type="HOGENOM" id="CLU_061789_0_0_1"/>
    <dbReference type="OrthoDB" id="3436015at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="32525" checksum="C2B9B2ADE1CE8302" modified="2010-05-18" version="1">MDQNQAGMTDTSVVGKWYDQNTILEHNRLMTSCIEYSITMRVIKQCLLELETSSGKPIRILDLGGGTGRYAVELAKLGHIVTLSDISQSELDYAAKFAGDSGVILENIVQADARHVRNNEILFRKGHYDLVLCMGPMYHLLEECERLAVLESCSLMAKPEGFVITAFVTKYAHLRDIAQRDPRRLCDESDFYAQYLSTGKYTRNPSNIVSHHIDVGDIRGLFDKLQRNGLANIRLERLVGCEGFLGGGLGATINLNDAETYEAWVDVRARYSMDPHVLGASDHIAAVARRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLB7</accession>
    <name>D4DLB7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000502">
        <property type="protein sequence ID" value="EFE37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017987.1">
        <property type="nucleotide sequence ID" value="XM_003017941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLB7"/>
    <dbReference type="GeneID" id="9579115"/>
    <dbReference type="KEGG" id="tve:TRV_07991"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="63815" checksum="593D7E40F5D16793" modified="2010-05-18" version="1">MGTRTSIDRPGPVASGLTPLQGYEKDDSLSKPEYHEAKTSGLKQREDRDSIEDPVSPSPKSGGLPQRPEGWSWTLAVIVLLASAFLYGLDTTIVADVQAPVIEQFGAVQKLSWLGSGFPLGSVATILPIIKIIYIASIILFEAGSALCGAAPNMNALIIGRVIAGIGGSGMYLGQESILMLTKSTLVLTDTRVLTYFSVFVPERRQPLYVSTSGFVWGLGTVIGPVIGGLFAHSNATWRWIANVAIKAFYINLVLAAVKAPVLLLLVPDYLPKPHKGALQKLKELDIIGMVLNAGIYVGWVIPMTFASTLWGWSDNRTIASFVAFGVIFIAFAIQQGIPLFTTLERRVFPAQFLRRTVMILLYVSTSCTNAALLVPAYYIPLFFQFTRGDSPVDAAVRLLPLIVLAIVSVMVQGITMPLVGYYAPYYTISGVLIVIGSALMSTVGVDTPVGNIYGYSIIIGIGTGLGVQASYGVAAAKVKEDEVQHAINYINLAQIGAETISLTVAGTIFQQLAFKNLSKYLAGRGYTSAELIAAIAGTQSVILQNGSEEVRSLAIEAIVEAMKKVYISMIAAGALQVICSVFLPREKLFMKSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLE3</accession>
    <name>D4DLE3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017966.1">
        <property type="nucleotide sequence ID" value="XM_003017920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLE3"/>
    <dbReference type="GeneID" id="9579844"/>
    <dbReference type="KEGG" id="tve:TRV_08017"/>
    <dbReference type="HOGENOM" id="CLU_565234_0_0_1"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="483" mass="54119" checksum="85680454D8D861D9" modified="2010-05-18" version="1">MTEALPHGIVFNTHSIRSELNHDSHVEVEDVARLWRVYTTNKTTLEKDAGRRLENLFWRIWSNGRISCTIRGYTLAFLFIQISEGEYTTEEWLRKERELAGLKPRAIPHGFYVDNSLPKSPSFQGPSRSNSSRLTPSGSSIKTTLPPSILKKPRPPSDEQLPDSPSRKDVTASYSGDSLYQQSDRSRSGSIRRKKTTFASNLTCSQEMEPGSLPRRINRPFPTRTLDSPAELRPQSPPSKFRGPFDDSPAQSPTSRPNNPAPSSLSRKPQFRSPFTTQSSQPQQKGSYTAQEGNLTANIRMSSTITAGDKMMLEEYLANSPVVIEDKPSSEQPSTASLVEKGFRSRFVKEQVKVKEQCHRVSSLTNLIDSVQPGPAPVPNTSSASSSFTSSKKSKPKSKHSPTPSTSSTHSTTALLFQIPPSSNPPQHYSTSPLFLIRVYLYECLVTIFWLRWQRDMKYIITGIWIDRSAFLSGNRGNRDSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLF9</accession>
    <name>D4DLF9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000504">
        <property type="protein sequence ID" value="EFE37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017956.1">
        <property type="nucleotide sequence ID" value="XM_003017910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLF9"/>
    <dbReference type="GeneID" id="9579837"/>
    <dbReference type="KEGG" id="tve:TRV_08033"/>
    <dbReference type="HOGENOM" id="CLU_030125_1_1_1"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="2">
        <location>
            <begin position="202"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="623" mass="69790" checksum="9B9A9428D3146B6D" modified="2010-05-18" version="1">MHGTLAKSSACYAALQGCVVDDARNRTYILTQLPTPRDSLLSLTGMSRSRSISTFFYSPPFVFFYNFPLFSSTGGSGVLIGQGVIVHVLVLPAGYSPFTMEKKTPNPLSPPYTAFYAGYKGGNNNHNSRDFLDQKHYRNQPPATSHLFFHLLPADIPDCFPGSDFVVMFINDEELNGVGKVQSKGIYHGLPVFPESLKGLSAIITGANGISGHHMLRVLAESPERWTNIYSMSKRPPLVPTKWKTNVQHISLDFLDSTPVELAMAMKENGVKADYIFFFSYIQSEPEDGGGIWSAAEELVRVNTAMLSNFLDAVKLAGITPKRVMLQTGAKNYGIHLGPTMTPQREGDPRVLLEPNFYYTQEDTLFRYCEETGASWNVVMPSFVLGAVKEAAMNMMYPLGIFGAIQAHLGRPLVYPGELASYMMPLDLSSATLNGYLEEWAVLTPKAANQAFNACDNSAFTWAAFWPTFASWYNLPYQIPDDEKSQYISIPTQYEPPPRGFGPRGIIRLKYALSHWATDPEVQDAWKVLSQKHNLQTNPFQSAKDIHRLFSFTDSALLMAWPLQFRSGLFVDFLFLFLLLFGFRTKCHKLGWFGAVDTIESMRQILYEFVGLRMLPPLPSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLL6</accession>
    <name>D4DLL6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Decapping enzyme Dcp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_08090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000511">
        <property type="protein sequence ID" value="EFE37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017924.1">
        <property type="nucleotide sequence ID" value="XM_003017878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLL6"/>
    <dbReference type="GeneID" id="9579802"/>
    <dbReference type="KEGG" id="tve:TRV_08090"/>
    <dbReference type="HOGENOM" id="CLU_008108_4_0_1"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="655"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="872" mass="97383" checksum="59CD78F6B4552476" modified="2010-05-18" version="1">MTEINMRLEDWLDDLCVRFIVNLPREELESVERICFQVEEAQWFYEDFIRPLDPNLPSLKLREFALRIFQHCPLMSQWSHYHHSTAFSEFLAYKTRVPVRGAILLNQEMDEVVLVKGWKKGATWSFPRGKINKEEKDLDCAVREVYEETGFDIRASGLIKDEKNVKYIEIPMREQNMRLYVLRGVPKDTHFEPRTRKEISKIEWYKLSDLPTLKKNKQHENVPYQNNNRFYMVATFLGPLKKWIAKQRKLDQARISHPHIAIQEEMGGAIITEDEGTEDHQDITEEYPTHPAPTMPILPPVHSDLPEVSTPLDPTVHLKRLLNIGSATSTAPTKQPDSDRQHEQQHQHVSNIDKGNALLQLLRNGSETHPPENPPLAPIPVHPSRALPTIHSQQTTPQPTPGQAFAPPITQFGTGNQYPQHPQNQISNQPPYTYPEQKSAAQPRHEYVGQAPHQMPHEPAKPPFTAYPPPLRQIGTQPPMSSTQHVTPPYHRTGDPQFASNHQTLQTILPSVPPANALPLPKLNSHSLALLSVFKGDGVKNTATMPGSIPASPVEPFPQNDAKSQHKNQLLRMLKQPSGSHLHNGGGLHPPGRVELATQNSPRIQGQTGMHPPGLSLDSQAKAPVILQNPHRPRTPSQPTVGKTAATLSAPLNLPNFEGIAKSPRSPRREKKHTPSQSSAMKSNIKILPRPTSNNNEGVPVAVKANTLSPAPRPNVKLSELTKPFKPKILRRPDKDNLDAYLPTSTVTVSAFSKPEPPPVSDDEVVQKSLPQPQFDQRPSQSAAQKETLLSLFNKDLPPQPTSIKRDITRQAKSPALVSPPFSTLISPVTDPLNSPREATREGGSERRSGATSPSNQAFLIGYLEDVATGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ50</accession>
    <name>D4CZ50_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000003">
        <property type="protein sequence ID" value="EFE45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025760.1">
        <property type="nucleotide sequence ID" value="XM_003025714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ50"/>
    <dbReference type="GeneID" id="9581991"/>
    <dbReference type="KEGG" id="tve:TRV_00087"/>
    <dbReference type="HOGENOM" id="CLU_054058_0_0_1"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="37389" checksum="189BFE87EFE96AB4" modified="2010-05-18" version="1">MADDAAATPARGRGRPPKAPGSASTPKAAASTAADGQPRKRGRPPKNGGPVTPKPVVLDANGQPRKRGRPPKNGIAAQSKSKTDASGASASAKKRGRPRKDASDGDGADASPPARGRPKKDADAKSNGAKGTTGTGTPGRGRGRPPANPLQKFLGSFALECAAVSDEWPDQCDSMDMSISASDLDPCGMVASFNLGIVEGTMLLALTQDELNAFHSKVEGGSGACYSIKLCHDYPPVQLLTTLNSTDSDSEEDAECDEPPAKKVKSAADEDSLRLYFKWKGRNTTDTEIHDGSRDVGTIDFLDSKAIQFKGIGSFPALGSKCEFTGTRYDKEPTTVPLPWSTFSDEAAQLANENRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ74</accession>
    <name>D4CZ74_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_00111</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025697.1">
        <property type="nucleotide sequence ID" value="XM_003025651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ74"/>
    <dbReference type="SMR" id="D4CZ74"/>
    <dbReference type="GeneID" id="9581938"/>
    <dbReference type="KEGG" id="tve:TRV_00111"/>
    <dbReference type="HOGENOM" id="CLU_044973_4_0_1"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055852" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE45086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="235" mass="25164" checksum="1E59288EC2B5E79C" modified="2010-05-18" version="1">MKLSLLTVAAAAGAAVAAPAAEIDTRAGSVQGFDISGYQPNVDFRAAYNGGARFVMIKATEGTTFKSSTFNSQYTGATNNKFIRGGYHFAHPDTSATAQCDYFLANGGGWSNDGITLPGMIDLEGTSGKPKCYGLSASAMIAWIKAFSDRYNAKTGRYPMIYTSPDWWQSCTGNTKTFGTTIPLVLARWASSPGTPPGGWPYHTFWQNADTYRFGGDSEIFNGGMDQLQRFAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ91</accession>
    <name>D4CZ91_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025714.1">
        <property type="nucleotide sequence ID" value="XM_003025668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ91"/>
    <dbReference type="GeneID" id="9581957"/>
    <dbReference type="KEGG" id="tve:TRV_00128"/>
    <dbReference type="HOGENOM" id="CLU_055356_2_1_1"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE45103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="262" mass="28675" checksum="471BA2DEDC186CE3" modified="2010-05-18" version="1">MDRSDRKTADGPGDDGGGDGQLPPDRLVDNAGAVEYWTTVEPNINGMLGGFPEISRADLLSSRSFLAKVRRLLPSIGGGTALSATAHLPPLQLGVDCGAGIGRVTEGLLSKVCEVVDIVEPVEAFAKVLIEGKLKAEGKVGDVYITGLENWVPEKRYDLIWIQWCLLYLTDDQVVQLLTRCKDALSPSGVVIVKENLNTKPHDTFDPQDKSVTRTEEKYKHLFQGSGYSIIREEDQLGFPRHLNLLPVKLFALYCEPNTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZC7</accession>
    <name>D4CZC7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025646.1">
        <property type="nucleotide sequence ID" value="XM_003025600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZC7"/>
    <dbReference type="GeneID" id="9581885"/>
    <dbReference type="KEGG" id="tve:TRV_00169"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_2_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE45035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="472" mass="50466" checksum="9A95368F4C8809E2" modified="2010-05-18" version="1">MASSGYAASDAALSSLNTELRPKLSSSALITASTDPDWEEYARWSAYNSPIPKAIVSPASEQDVAVIVQHCISHGVPFLAQSGGHGWSSTLNLGRDGIIISLRKLNTVTFNRDGTEVTIEGGALTSEVMEAASRKGSLVITGNCNSVGALGAALGGGYGFLTGLQGLAVDNILSLTVVSGTGTLKTVTAESDPDLFWGLRGAAPNLGIVTSVVMKAYPVEASGQYAWLGALVYPADKVEPVLRAVSELTLTPKMSVFFYFLTSGAPDYSPLVAVAPWYYGTEAEGRAAFASVIDIGPIADTTGVLHYTRWNDKAAAFCIRGGYKPSFGVGLSSIVPETWIKVWDEFVSWAALSGTGSSVVLMEAYCLDKVRAVPDHSSSFPWRSNIAINAIVIPWFTDKKLEEEALSLGRRIRRLLQSTDGLKAPAMYINFAHGDEDPAEIYGSNLTRLRDIKAREDPNNFFCHWFGVGSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZF3</accession>
    <name>D4CZF3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000013">
        <property type="protein sequence ID" value="EFE45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025628.1">
        <property type="nucleotide sequence ID" value="XM_003025582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZF3"/>
    <dbReference type="GeneID" id="9581871"/>
    <dbReference type="KEGG" id="tve:TRV_00195"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="454" mass="50540" checksum="868137118BCCCAA1" modified="2010-05-18" version="1">MYMVTPYMEHDLSGLLENPDVHFSEPQIKCYMIQLLKGLQYLHERILVLPGPMTKRHLLLVREAEKQRENIRRWLSPAGIGRRNFFSNYVAILPRLTCGVLGNVNPSYPNVPIVDLQNANYRDRCVFGEMFKGKPILAGTSDLNQAQLIFNLVGSPTEENMPGWSSLPGAEPIRSFGFKRPTLATVFHEQGPVAISLLTELLRLDWRKRINAIDALKHPYFTTPPLPARPGDLPSFEDSHELDRRKFRGQKAALPPAPAGGSVGMGAHGEWTSGSSRGAPTTDPKKSRVPQAARSGYGNNMHPSSRPPYDSRMPDPVHGHKRKASGEPHSHLPAWQRDANLSPKPPAPANPQWQTGSRRGGGPGQDSRRDRPPIPRGGGGISDSGRDSYVPNYVGGGNDRYRSGVDGPMPPRRDNIDPAARDRYWRPSRSRSPEMRDRSRSGDPGSLSHHLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZH1</accession>
    <name>D4CZH1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000015">
        <property type="protein sequence ID" value="EFE44962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025573.1">
        <property type="nucleotide sequence ID" value="XM_003025527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZH1"/>
    <dbReference type="GeneID" id="9581811"/>
    <dbReference type="KEGG" id="tve:TRV_00213"/>
    <dbReference type="HOGENOM" id="CLU_021703_2_0_1"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="401" mass="44219" checksum="E1270BEA625352F1" modified="2010-05-18" version="1">MPILNSPFAPSAFANSSGRGEVVLTVLPPAIPSLSTVSYNYPLKLLSRTPEGELKSRYPATATPHLHLYLLTYGGGLLPGDHIDVSVTVKPRGRLVVTTPQGSTKIYKTEAQGGRKRPIPKTDNDRSKQTLKVQLGRESGLCLLPDPSAPFADSRYDQFQTFTLLHGDHSKAAGSSQGDEGVTKPAHKGSLCVLDWVTEGRSARGENWSFDSWTGRNEVWLEDCKTGKRRLLLRDAVILNNETAAQKQLDANDPDSSAESHMSSTQSQTSVRSRVHPHGVLGTLIIHGPLFESLADFFMEAFTSQPRIGGQNWSSSSTYYPTHTNEHVNNNEKYDNHDDTTKPAEMRHRNVTWTAARVRNGFVLVKFGAPDFENARDWLGHMLRAEGSIQREFGEEALGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZP5</accession>
    <name>D4CZP5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025525.1">
        <property type="nucleotide sequence ID" value="XM_003025479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZP5"/>
    <dbReference type="GeneID" id="9581762"/>
    <dbReference type="KEGG" id="tve:TRV_00287"/>
    <dbReference type="HOGENOM" id="CLU_125047_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="150" mass="16544" checksum="C14913A438A4D73F" modified="2010-05-18" version="1">MDENMENTAGPPVNPAQEAGSDLDKYPSKSAQKMDDQTPKSPVAASTKDLPKLPQEEEENMIRSLRTKFKGGDAGELHNLLSSLELAEKERRSGSPTLDGLEAVLSQIDMMWRSNSTYMAEVAEMLADASRDGKVASLRYETVYIYTDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D003</accession>
    <name>D4D003_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025457.1">
        <property type="nucleotide sequence ID" value="XM_003025411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D003"/>
    <dbReference type="GeneID" id="9581693"/>
    <dbReference type="KEGG" id="tve:TRV_00397"/>
    <dbReference type="HOGENOM" id="CLU_033816_0_0_1"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="140"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="579" mass="63535" checksum="9C0FBA59C311057D" modified="2010-05-18" version="1">MEQWPFDKKGITMEKADSSSPEIRAKKIFACGFSQKQGGCFDLSMFCSFDSRNFGSMADLVSLEWDIENSRSFVSPPLTWNRWNWVDGSNPFPWQIPKSAKRQQKDNHRDKQQRRRDRSEKELQRRRQRAAIMDAKLLKTTKFPPEFAKKVDMTKVNIEVMKKWIAERISDILGNEDDVVIELCFNLLEGSRFVRGQTDSRLLVSLLRVEFDGLTINLTGFLEKDTAKFCKDLWNLCLSAQDSPQGVPKELLEAKKLELMQEQRESGGERERIVAVAEEAAVALLVELIGTTAEILPRLIDGDEAHRFTEIHLAGEQISTFPAVVEAIDEMIIEGAARRDSPLLRRPGHHHALSRQFGTVDGIGGLPKEGGGVRPAALAHLIEVTVTVTVTVAGNEPAARPMMTTPGPQAARRPEEDGEDREAEALSLHPLLVIGLRDPVVHLHYDLRRGQVARVIGEVGALGGDPLCTNKGLDVMYLELILLKIAEVTTTAGLAAAVAAVAAAVAIEREAGVEAAEDTAEDSGRPAAGHRRAAHVAAAAAAAAVAGGGINLLKDMPQLDAGRARTVLPLHHLLKSDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D012</accession>
    <name>D4D012_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000021">
        <property type="protein sequence ID" value="EFE44805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025416.1">
        <property type="nucleotide sequence ID" value="XM_003025370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D012"/>
    <dbReference type="GeneID" id="9581652"/>
    <dbReference type="KEGG" id="tve:TRV_00406"/>
    <dbReference type="HOGENOM" id="CLU_025395_1_0_1"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="513" mass="55434" checksum="FCC63296E944F8D6" modified="2010-05-18" version="1">MADALYELLVPHFDAAEGSPRLSSPPPPPATSSTTAQYLNHIPTLDTASLTSTELQSLSQVSHSNLVSLQALANRSHKTFITSADNHRSLQKSLPQLARETQRLRDAIPKLDEEAVRFSSTYSKTGDSQILERRKKALQLARNVDRLSDILELPTLLSTAVSSSSGASSAGAGSGAGSGTGGTLSSSSLSSTSNYSAALDLFAHIKRLQTLYPESPLARDITNQAEDAMKDMTTNLISDLRVQNIRLAPAMRIIGWLRRIAPDLEEPSSTKSASGGSTSEGAYGALFLVCRLANLLNMLSALEPLRELADQETLRRRQNTTKGETSEGSKNNNTWSGGQQTERFLKKYIEIYREQSFAIVSLYKNIFAPGTLDPATKQQETEEEELSEASMLSQLPPALATFPMHLAQLLAETLEEYLPNVRDKSSRESLLTQVLYCAASLGRLGGDFTMMLSLLSTTGGTDQDDEDGDETEAVPEWEEAIRKHRILAERLDLLTAGSEAAGGAGAKGSSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0A1</accession>
    <name>D4D0A1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025316.1">
        <property type="nucleotide sequence ID" value="XM_003025270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0A1"/>
    <dbReference type="GeneID" id="9582933"/>
    <dbReference type="KEGG" id="tve:TRV_00496"/>
    <dbReference type="HOGENOM" id="CLU_056776_10_0_1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="72" mass="7932" checksum="0400CED171732119" modified="2010-05-18" version="1">MLTVSKPVAKKIAIAAGVADFNILQNNGRIAHQFVDHIPKPNEPEGLGIDWPAKEADKEDLKVLLEELKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0G1</accession>
    <name>D4D0G1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000031">
        <property type="protein sequence ID" value="EFE44668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025279.1">
        <property type="nucleotide sequence ID" value="XM_003025233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0G1"/>
    <dbReference type="GeneID" id="9580771"/>
    <dbReference type="KEGG" id="tve:TRV_00556"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_0_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="255" mass="28946" checksum="1D34F66B84A75F64" modified="2010-05-18" version="1">MTEDRKDVKITLYWLEQSRAQRILWLLEELKLPYELQRFKRDKGLLADPALQKIHPLGRSPVISVEVPGREKLVLAESGLIVEYLTEHFGPSLIPRRYREGCEGSVAGETDAWLRNRYFIHYSEGSLMPVFLVQLIIDRIRNAPVPFFIKPLTRGIAGKVDDAYLRHNMKLHLGFLEGQVKSAPQGGPYLCGPDLAGADIMMSYLLEIATASKAITADSHPALVAYLDRLRQREAYRKANDLIVELEGSCDYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0K7</accession>
    <name>D4D0K7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase delta subunit 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000034">
        <property type="protein sequence ID" value="EFE44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025236.1">
        <property type="nucleotide sequence ID" value="XM_003025190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0K7"/>
    <dbReference type="GeneID" id="9580729"/>
    <dbReference type="KEGG" id="tve:TRV_00602"/>
    <dbReference type="HOGENOM" id="CLU_077732_0_1_1"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="248" mass="27992" checksum="D0465DC7F73A0D42" modified="2010-05-18" version="1">MDNQRFSNYQADEPPGSQRRQTDRQTDTNNGSFLSTAKQQESHYRIKILLLTVDMAPRRKAAESRKSNQATLQFGTQSKISKPFSNASIPGKDLKQKSPSPKEISLPTHSLPKKQDEEQQQLQEPTAEVTTTPASTTSTAVVHEQARAEAALPKSKEDEQAEALTLKQLHAYWRAEERKRTASRANKQQKQADRNIICQPCIGIARIKRWRRAHALGLNPPIEVLAVLLKEETREKASEKAYIDELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0N9</accession>
    <name>D4D0N9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_00634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000039">
        <property type="protein sequence ID" value="EFE44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025179.1">
        <property type="nucleotide sequence ID" value="XM_003025133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0N9"/>
    <dbReference type="GeneID" id="9580688"/>
    <dbReference type="KEGG" id="tve:TRV_00634"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_7_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF199">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14519" checksum="5656E93394187819" modified="2010-05-18" version="1">MRHLTTIYQTAVSIQAYTLNRDPSFFHSATSFIPERWLPEASTNPKSPFYHDQRNAVQPFSVGPRECLGQHLAWAELRLILARLVWAFDFEAVEGKKLRWEELRTFLLVEKKPIQVRIKRRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Q6</accession>
    <name>D4D0Q6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine-serine-proline rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025169.1">
        <property type="nucleotide sequence ID" value="XM_003025123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Q6"/>
    <dbReference type="GeneID" id="9580662"/>
    <dbReference type="KEGG" id="tve:TRV_00651"/>
    <dbReference type="HOGENOM" id="CLU_1688007_0_0_1"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="156" mass="17589" checksum="B78CA73B1C2331C8" modified="2010-05-18" version="1">MVNHSKEAEVFKGCPFPRPLLLVVLILPTQNILSITVNTSFYQLPPPTTNMSFHETAREVRLEDDSILVAELRNDNGDYVTARFDLNSVLGNDDGRFIWSGRDFSNSASNIWFQFDEATNLPILRATLANSDGEEFDRDVNLAECITNNNGCFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0S8</accession>
    <name>D4D0S8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000042">
        <property type="protein sequence ID" value="EFE44537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025148.1">
        <property type="nucleotide sequence ID" value="XM_003025102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0S8"/>
    <dbReference type="GeneID" id="9580641"/>
    <dbReference type="KEGG" id="tve:TRV_00673"/>
    <dbReference type="HOGENOM" id="CLU_002027_1_1_1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="834"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137819" checksum="C41521D38D868676" modified="2010-05-18" version="1">MNANDEDGTDQQSIKPVSSLLSHFENLSHTKREAQDGPGSLLKSPPAADNVATGRVSLDLPRSNTSWGGSQRPSQGFLRPQQTGDSPTRRPQSRPLSMNLQSSPPGRPIYTAESSRAPPQPNFSYSQSLPHTQSRPPHAFYAPNGHATSNEPSSSPPSSSRTSTRPTTPLDSPSHSVSIDIRRTTPVSQRTGHVGKSTSVPPPVNRAEKPKIPLRKPGLSPGHDAPASNTLAPLPSSQRTSMDDRISPFSTPPSSPEKGPGTPKLNGVLEPLSLGEAHVTSRIQQSQPAPRPSPGPISREGPPVSRLTKGNLISGTVPNAISPRLPPAVGAKAAAAIPIPQPFNRPNDDDDQPVRQNAQGRRPSPAPPRRLDTSRAALGLHREDLPSPQRVVSAVEPQAPNPYKLPPRSLSIKHSKPTPPPPPPPRRETSNLSVKSNQNTNRPPPPPSNPPTRYRPPVTATTNDKDAIKSLEQLTRRPEPVVVTDTDIHPDATLTNRRPPFFRSGAADVYTKYDTRVFDVCGQYACTTGFYTRVWDLVTGEMVMSLNHGETVKGSAIAFKPGRTVDEEGAIIWIGTTAGELLEVDVRTQAILNTRPAHSRREIIRIYRYQKELWSLDDEGKLLVWVPDESGAPNLQYSYNHPYDRMVKGHTFSMVVGDTIWYATGKEVRLYRPHAQDTAFQVLTSPLGKHHSSEVTCGTMTTSNGGMVYLGHADGKVTIYSSKDYAYLGTVTVSMYKISSLAMVGDYLWASYKTGMIYVYDTSTNPWTVKKDWSAHNHGVCGITLDLSSVWTVNKLQVISLGVDNYLRIWDAMLEEDWLEARMQSRDVEYCQFNEISAAIVTWNAGATVPGKLPNSNFIRDAIHPESAPDILVFGFQELVDLEDKKITAKSFLKGKKKDADKERMSRQYRVWKDYLALCIREHMPINESYVLLHTASLIGLFTCVFVRQETRERITNVSAAEVKRGMGGLHGNKGALILRFLLDDSSLCFVNCHLAAGQSQTAHRNNDIAAIMESEALPREPSMSARIDRYTGGGDGSMILDHEICILNGDLNYRIDSIPRNTVIEAVKANNLPKLLDRDQLLASKRKNPGFRLRTFNEAPITFAPTYKYDVGTDDYDSSEKKRAPAWCDRLLYRGFGRIKQLEYRRHEVRVSDHRPVSGTFKIRVKSIIPKKRTATWESCQEEFLTEKQRLATEARYVLPTFVYRDGCLTSFTNPLINSVSYLVRFLGLSPREAYALITSPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4D110</accession>
    <name>D4D110_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_00756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025098.1">
        <property type="nucleotide sequence ID" value="XM_003025052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D110"/>
    <dbReference type="GeneID" id="9580590"/>
    <dbReference type="KEGG" id="tve:TRV_00756"/>
    <dbReference type="HOGENOM" id="CLU_030273_1_1_1"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="158"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="424" mass="46570" checksum="5326F6B7BC09E209" modified="2010-05-18" version="1">MATIFPTIKTVNTFIIDGVGSGGDYHNVCCYLFSSEVYCLYINILFQVKGGHWLIDSPIATPMARWEQYRSSRTSWGINVLGSFCVEIEATDGTKGFATGFGGPPACWLVAQHFERFLIGADLAIWDLLGKIRNEPVYKLIGGTTRSRLDFYCTGPEPGYSKAMGFSGAKVALPYGPDEGASGLARNVEYLQQQREKVGPNFPLRVDCYMSLNVPYTIELVKACEAAGINIDWWEECLSPDDVDGQALLKRAHPTIKFTTGEHEYSRYGFRKLIESRNLDIVQPDVMWVGGMTELLKISAMAAAYDIPVVPHASGPYSYHFVVSQPNSPFQEYLANSPDGKTVQPVFGDLFLNEPIPSKGYLDVSALDEPGFGLKLNPAAKLIPARYILTPGPQVSLRDNSIASRKDGKHGSENSVPITNGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4D115</accession>
    <name>D4D115_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_00761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000048">
        <property type="protein sequence ID" value="EFE44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025103.1">
        <property type="nucleotide sequence ID" value="XM_003025057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D115"/>
    <dbReference type="GeneID" id="9580595"/>
    <dbReference type="KEGG" id="tve:TRV_00761"/>
    <dbReference type="HOGENOM" id="CLU_931236_0_0_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="299" mass="32597" checksum="90F11C3B82622D99" modified="2010-05-18" version="1">MSEHLFSPDRIDSVQNADMGMQTEIPRLRSTKKEYPPAHYLCDGRSRRTDSSAGRATEISCQVDIHPDKTTSTPEPQASIKISKHKHIFFDTSAPSKKEISSFIKMSVLSRAVQLAFVALGLCLFFSNLVAAQPIAGPSLGVSVKSVNGVCRTNKPCELEVTVRNTNTKKPATVLNWNTPLDPYADQLGVFEVRDSKGAVVPLDFIQIRRITPPPASDLVEIKAAGSVKVKVALETLSRAELPAGTKYTVTATGWWQAVWDQPKEQVVQTHLQELSGAFSGNFNSNSVQVTKVCSSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D165</accession>
    <name>D4D165_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_00813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025008.1">
        <property type="nucleotide sequence ID" value="XM_003024962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D165"/>
    <dbReference type="GeneID" id="9580500"/>
    <dbReference type="KEGG" id="tve:TRV_00813"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="256" mass="27830" checksum="9447097121D0A6CF" modified="2010-05-18" version="1">MADAARGRGGFGSRGGDRGRGRGGRRGRRGAKSEEKEWQPVTKLGRLVKAGKINSIEQIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVVIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVLPVRRGYWGSNLGEPHSLPTKTSGKCGSVSVRLIPAPRGTGLVASPAVKRFLQLAGVGDIYTSSSGSTKTLENTLKATFVAVGNSYGYLTPNLWKETKLNRSPLEEFGDVLREGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Q6</accession>
    <name>D4D1Q6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI ethanolamine phosphate transferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_00999</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024834.1">
        <property type="nucleotide sequence ID" value="XM_003024788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580312"/>
    <dbReference type="KEGG" id="tve:TRV_00999"/>
    <dbReference type="HOGENOM" id="CLU_003591_0_0_1"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1217"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1283"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1322"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1439"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1481"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1513"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1544"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="18">
        <location>
            <begin position="402"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="16">
        <location>
            <begin position="834"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1402"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE44223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1592" mass="176978" checksum="E7DB28C8B789706D" modified="2010-05-18" version="1">MPKRKAESKLSSLVNGDIEDDDLSRVEDDDNASIEPPPAKRQKGRPKAATTKATAAATKTTRKTRSKVVVGPKKRGAAAGRKKTAKVVEEPPADDVDSAEEENETLGREGVSEDELDSPETVHNQESQEKTRTRGRAKDTETIKDGEFEYTPTNTKSAAVRGQKGKQTAKQAAKEPSPPVEITPETVKSTSRTSISAGKTQRFTPSGVHWASPVKSTNVLPQHRTSRPSGIKPWGSPTKGRETGDGEVALRLKLGEMTKKYESMEGKYRALREIGIVEANSNLEKIRKQHEETTAASKQLINSLKSELSKQSSASKQTRDLQKQLESRNEEVAQLRQQLEEMKSGLNKAQTEAKSLQTKLTAARNAAANAEKVATARGSAVRSGAVTRDTANGLLESAQVAQLKEDLYSDLTGLIIRDVKKRESDHLYDCIQTGLNGTLHFKLGVSHNMDNRSTASLEAAEFHYIPLLDENRDRDLLEILPDYLSFVLIYSSIHRHFPQFLITSSSLRLFHLVFLCGHPPKVLHPFLDLSLTKNFAIFTFFGAGRGALCPSIQSEAPAQSKASTFFRTLIRCPTLKKKLLLEGERKKSCAAMSRTGLFLALAVLFHLIYTYSIFDIYFVSPIVSGMREYGVERAPSAKAPAKRLVLFVGDGLRADKAFQYFPDPSPPKTGCSKDSEDNVTCPEPDLTPKPLAPFLRSRVLDHGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVNFDSVFNRSRHTWSWGSPDILPMFKEGAVPGRVSVDMYSEEAEDFTRDATFLDIWVFDRVKEMFAAAREDKELDAQLRDDKVVFFLHLLGLDTTGHFYRPYSKEYLHNIQIVDQGVREITELIEDFYGDKETAFVFTADHGMSDWGSHGDGHPDNTRTPLIAWGSGVAKPVKSKKGVVAPGHEDGFSSDWHLNDIKRHDVAQADVAALMAYLVGLDFPVNSVGELPLSYLDATPKEKAKAALANTQAVLEMYRVKEEQKKATTIKYQGYSSFTQPQRSPEAQLAAIRKLISTRKYEESILQSRRLFQDALEGLRYLQTYDWLFLRAIVTAGYLGWIAYALVTVIDLHVLPTSPEPDRSVPSFMFFSSVLMVLYSLLWVQQSTWRYYAYAFFPVFFWEEVFARRAALGAGRKILLGHVKSFTGYAMFLLQSSLYIGVLLGLVQSYFNREIYTYCYLLGSVWPALYGFEFLNKNKLLSAAWTISCICMSIFTLLPVGKQDDADTVTCGGILMFATGMLYLIFEESILSSSKIGTRSGSTFNIGSRIVMGAQIGLILLSIIVTRSSIASLQERAGLPLGNQVTGWIAMVSSFILPMLHKLFPTGHYFHRLILLFLTFSPTFIVLTISYEGIFYVVYFATLVSWVRLEYSIYKHTLPSIPTRPTLSREDTPRPTSPGFKPATPNTNNSTYRPLNISDARIALFFLFLLQSGFFSTGNIASISSFSLDSVSRLIPVFNPFSQGALLILKILVPFALLSATFGILNRRLHVAPSALFMIVMCISDVMTMNFFFMVRDEGSWLDIGTTISHFCISSALCIFVALIESLSGVFISGVELDGYRAQSDLGEEKDTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1U0</accession>
    <name>D4D1U0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024803.1">
        <property type="nucleotide sequence ID" value="XM_003024757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1U0"/>
    <dbReference type="GeneID" id="9580293"/>
    <dbReference type="KEGG" id="tve:TRV_01042"/>
    <dbReference type="HOGENOM" id="CLU_2564824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="82" mass="9004" checksum="A658C7B4C51A9C5A" modified="2010-05-18" version="1" fragment="single">TFTTAMADSMPQVQIELPGDVEMEESTAPAAEEDPSAETTKEEEKDKESGDQETQPPAEPEVHSQQAVFLKYAQLRSTAYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Z1</accession>
    <name>D4D1Z1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024744.1">
        <property type="nucleotide sequence ID" value="XM_003024698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Z1"/>
    <dbReference type="GeneID" id="9580234"/>
    <dbReference type="KEGG" id="tve:TRV_01093"/>
    <dbReference type="HOGENOM" id="CLU_2308113_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="100" mass="11290" checksum="76EBCB157C4A9DC8" modified="2010-05-18" version="1">MQKAEEDEEEEEKEEEEEEEEAKGQQGDKTRKMTTCYAHVQSRAGEEEAAALPQTLLCSSREPALLTYLTVHPLSQPGSLRVKKHVLFHFICPPPPTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D264</accession>
    <name>D4D264_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_01166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024649.1">
        <property type="nucleotide sequence ID" value="XM_003024603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D264"/>
    <dbReference type="GeneID" id="9582845"/>
    <dbReference type="KEGG" id="tve:TRV_01166"/>
    <dbReference type="HOGENOM" id="CLU_040663_0_0_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE44038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="253" mass="28964" checksum="81593392AC12C7C6" modified="2010-05-18" version="1">MSDDITASKTAKLACSHRICHGCLRRAFTLSITDPQHMPPRCCTSDHIPLKHVENLFDLKFKLKWNQKFREYTTKNRIYCPSKGCEKWIPPANIYRATGSRGASRRRYGVCSRCKIMVCCTCGEKWHKDEDCPQDEGSIQFVEIAEQEGWRRCYNCSAMVELKEGCNHITCRCTAQFCIVCGLKWKTCDCPWFNYVDIPDNAVPPGGAVDIRDPVCYQEEIDRRREQEADDEALAIQLQYALALGMDPNLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D279</accession>
    <name>D4D279_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000064">
        <property type="protein sequence ID" value="EFE44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024664.1">
        <property type="nucleotide sequence ID" value="XM_003024618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D279"/>
    <dbReference type="GeneID" id="9582839"/>
    <dbReference type="KEGG" id="tve:TRV_01181"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_1_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="311"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="708" mass="78364" checksum="BF51D7D7E42E2047" modified="2010-05-18" version="1">MLEAERRQRRPAVNKPTALISVEGSNLKGADCISSERPASQSYPPSLTEGSTNGSAAVSQQSNDTVSMDSTRASSRVNQPHNLNLNNYNTSSPRIKETSSQLGGTFQIHRRAGLPGGPLAISGTTTHKGRSFGQSHWVNLISLFDDICGTVERHLQHNQPIALSNVEKCKALARTIKSRRVPSGPINLTLDLPSKKVSDELVDCYLQTIESVYRILHIPTFRRVYETLFLSAVDPAVNDAFVVQVKLVLAIGAVTYDKDFSLRTLANKWIYEAQAWLLDPKFKSRFNIQSLQSHLLLLFAQEMVGIDGDPMWVSVGTLLRRAIYMGLHKDPDGVPGNTLFVIEMRRRVWNTILEVCLQPSLTSGGPPLFSIDDFDTKSPRNFDDEQIEDSTAIQKNEFTQTSISMALRDTLPQRLAVITFLNSHGSLGTYETTLQLDKELRSAYKSLCHTIQGYVRKSCPSPLFEFRAVDLIMQQYLSCLHMPFFGISLQESAYTFTRKAIIEASSKIWHSIYQTSSFPPRQSNECPASSPHDRLTLLATCGSGFYRTALLQATLLIAAELRAQIQDSESLGPIPLSQDLFTVLKNAKAWSIQCIEAGETNIKGHLLICVIDAHIQALLKYPVEDCTPASLIGALDDASAASLSILSRVATMDNVENSTGALHEMPLDNMGEGAEDWRFMVGGELPNASPIFRPHLTHSIRWPIQCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3U7</accession>
    <name>D4D3U7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000093">
        <property type="protein sequence ID" value="EFE43472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024090.1">
        <property type="nucleotide sequence ID" value="XM_003024044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3U7"/>
    <dbReference type="GeneID" id="9577078"/>
    <dbReference type="KEGG" id="tve:TRV_01759"/>
    <dbReference type="HOGENOM" id="CLU_034110_0_0_1"/>
    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="432" mass="47199" checksum="C697D0B03D1844DE" modified="2010-05-18" version="1">MMLLEIEAAVHGVNGKAELTISTIGAQEDVIAVCDEQPLPVAPMKLVLYDDIPSSPRRADSRASLLPNLVTETRSRASRASNRASLLVKHKKRSKNTPVRKLKISGPTDFRHLTAGSTPTPRRRRRSFRPLELSIYVEGNQLPDLPAFDTFGLDDFDLEGFGQDSSRSTGTTTDSTTDPIIAPPPKAVCVPDQKDDRRRSESTSSPFAVARKPIGTSSARNSLFIEVHDRRHTIPDPEKLQEIQNAISPPRRSSETLNGYPLSSLEDLTDLKQTESEITPSSVSPSKGHNSSSAPIPTHYPTRSRTIAEWFAAKSHQGRPPSSFRFDTSHARARTLSGSTMVSLANASTAGYSSRNPSLSSSVMMGTTTQSPLSFHALTEKDYEICDIAMGYKTSSQEACSTPNEKRQSQTLTDKGPYYEIPLGPNDIGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4E4</accession>
    <name>D4D4E4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023909.1">
        <property type="nucleotide sequence ID" value="XM_003023863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4E4"/>
    <dbReference type="GeneID" id="9582521"/>
    <dbReference type="KEGG" id="tve:TRV_01959"/>
    <dbReference type="HOGENOM" id="CLU_019189_13_0_1"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="595" mass="68500" checksum="E403F76441ACE903" modified="2010-05-18" version="1">MKLPWRLLCFTKTHRSARKPQFTRCHSSDSRAMHTIPRQSQDWNIHDEFFQFTRGRFVIDEKEQLSKRHVRFNMNELAQEAAKAVGAKYCINVEKCADGMFNKAYIFTLDNDKQVIGKVPNPNAGIPHYTTASEVATLDFMRNVLKTPTPKVYSWNSRKDKGNNVGAEYIIMEKFDGVQLGQVWPSLDPSDKMKIFLQIFDYQRVWTQKKFNAFGSLYYRDDLGESIRRPLADEEGTQINELDRFAIGPATGREWSDDGRSSLTCDRGPCECFILPDDAKLVFIIIIACNQGKSLLEYRIAVGHREKLAIESRICAPKQLAMLYGPGLYRPTQEKRLDAVQCYLKLVSILLPSDPSLASGHIWHDDLHSENIFVSPKNPTEVVGIIDWQSTQISPLFDHCMDPAFLEYDGSPIGDSLKRPELPENMKQLSESEKNDTIKQYLNKSVMVAWRMLVKNKNPSQYAAMMFENTTKGYLLLLSRRLYELGEPQFRALSLDLQKEWLKSNANEEQKFPLSFSPEQEIEINADRELSALSSEVMKSIQQRLGRIWPDKALAEHDDYQQLKPLLAQIKEELASELVKAPEEKAEFEKFWPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4F2</accession>
    <name>D4D4F2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000103">
        <property type="protein sequence ID" value="EFE43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023917.1">
        <property type="nucleotide sequence ID" value="XM_003023871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4F2"/>
    <dbReference type="GeneID" id="9582529"/>
    <dbReference type="KEGG" id="tve:TRV_01968"/>
    <dbReference type="HOGENOM" id="CLU_2335158_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="98" mass="11033" checksum="A457DB3C46993996" modified="2010-05-18" version="1">MDDYNDYYLLFVFFFFLLAFLCFEARSSQAAQSFSHSKRHLISSSILLPFFFILLLLVTNYPFSLLRPAPHSSPSSSPVMSSSLPSSLLLPLPPSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4H3</accession>
    <name>D4D4H3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000104">
        <property type="protein sequence ID" value="EFE43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023868.1">
        <property type="nucleotide sequence ID" value="XM_003023822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4H3"/>
    <dbReference type="GeneID" id="9582479"/>
    <dbReference type="KEGG" id="tve:TRV_01990"/>
    <dbReference type="HOGENOM" id="CLU_011816_1_0_1"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="438"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="764" mass="82036" checksum="574F84B85BE246B3" modified="2010-05-18" version="1">MSDRPTSPSKGSEGDADRQKSPSIEQSGGGAGDGGGAGSEQSSSQASPVMDVFSDEFSVERIDNSSSNSQRQSVNSLSSHSSSSSDKTETRDGQDQISIPPLPTSSFQGIPESLERRASQLLQQQQQQYQQHHHHHQTVTPQVPDKKHFPPDAGPVPRTSSPAVSIAQSTASASHRSVSTVSRLSIPPRALSPYTGQTGPSHPYAMYSQGISVNRTSSISSNSTVRPPERNFVAAAPPQHPYALYSQNTVPEHVPDEPLNTTVPLPLPGHPQIYSQPAPAPVADEVGDILGTDGYREQLPPYTRYPEGIPEKSYYAPAAPTGVPGTTNTPSQPLETPVSPVSQVSSRTLLSENVPGAVAPAADSSAAESGNTSQEIVNEKEKRRNQKICCGLPLWIIGLIAIGLITGTLIGGVLGGIVGARQGQKDSGKTPDPDHQPTHGTLDALPLPTTSGAPVFSPIPTGPISISGRTFNSLSQSCVNTTSLRLSWDCVDYGHFKGSISVGPKDTRTIKFSQNSLTGKFIYGDQIPFLANKDYQLQPAYDASAPDDGPAYFFYTTFDKLVIVPDDEFPYGVLGRSVKDSAQLKRSNNRSGKVQSQPGDKPWFCWWNTTYIELFVYANKNATEDDMKTSSDGSDDGMPSTPPTPYPRESTPITASSSPTSTPITMSGEGGSNLPQAYPQAIKIKELRFSDASQSPPYCQQMQVLDDWSLSTLQNQATIEEKDSRSGPDSENIDISQKLARRSQLIGSRDVVPDQCYCEWLYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4I0</accession>
    <name>D4D4I0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023800.1">
        <property type="nucleotide sequence ID" value="XM_003023754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4I0"/>
    <dbReference type="GeneID" id="9582473"/>
    <dbReference type="KEGG" id="tve:TRV_01997"/>
    <dbReference type="HOGENOM" id="CLU_1152445_0_0_1"/>
    <dbReference type="OrthoDB" id="4173680at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="261" mass="28898" checksum="55B2DA5E12A3EC72" modified="2010-05-18" version="1">MEDRLHYLRWKPTITALSPNNLSSNARPRSQVPVSSSSTRATSGLQGPGLARYVRGSYTLFSGYNIDQINGILVSDDGNGFLLAVPPEASLRSTAAEAVSSSARRETIKATGHPSTISDYEIAKEEQDFEDAIQNSLKDHRTPAAAPRVRCQHSNPVADRPSAASHRSHQPLNTQTLWRLYQEQQETSVDRHQRVPGIRPAVLHPPAHRITCTICNGSRAVRQDEAIADGLPICESCCDEILRAEQSRAEQVERERRVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4K7</accession>
    <name>D4D4K7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2p, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000105">
        <property type="protein sequence ID" value="EFE43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023827.1">
        <property type="nucleotide sequence ID" value="XM_003023781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4K7"/>
    <dbReference type="GeneID" id="9582402"/>
    <dbReference type="KEGG" id="tve:TRV_02024"/>
    <dbReference type="HOGENOM" id="CLU_009486_1_1_1"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="751" mass="80816" checksum="7D160C297C6038C1" modified="2010-05-18" version="1">MAAAVAQGPSSVRRPKDRDRERDRDREKPENSLSTLRDPRVASTSDLSRTRSASTASHHPDLSNEVANLSDKLIQAINHQTLLDDSLAVARQELEEERKRRSTVEKEKKGIETELETLTAALFEEANKMVAAAKQEREVVERKNEQLRAQIKDTELLLASHQEQLAELKSVIEQMNSRHDDQDTATTATSISSPSDPFPDQPTPNNGNGNNHNINRLFEAMNLSPVTPGSDDIPPAPPTSFSHLLKPVCRTDILAYEDFNTLLQLSRSRPPSHVSSGSYSGLNVMNLANLTSSRPKSTTHTPTNSQDTNHNGGNSNNVNTGSPAAASSSVASSPSTSHGGISSSPRENITSSMQLKETRFYKRILAEDIEPTLRLDMAPGISWLTRRSVMSSLVEGELIIEPIPSNTSSANSATDLPSPPSTPSSMSSTSTPCALCGDRRTTVNPRTHRFRTSSSDSAPKHALCLLCLEKMRACCEFVGYLRLVVDGHVRTGGDGEAEIKEREREAWEETVRLRERIFWARIGGGVVPAFISGKKAEDDSEKEKEKIQQSDDAPLVIKDITVTSPADAKQTPVSTPTKPEAETETTEQLASSISTPTPTPTPAPAAEAEPSTAPADTPSTSTLSASTTTTTTRSLSLSPSRYRSRSPSPSPKPAPSSRPATAIPPSPTSTSQTPRTVLRRLRSVPPPSTPQSPSTVTSPDTKFPKVMPVSLRASLANGSSTTSTPSTSGPAPAPAEGKLKVKIPAAFLHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D513</accession>
    <name>D4D513_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000117">
        <property type="protein sequence ID" value="EFE43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023674.1">
        <property type="nucleotide sequence ID" value="XM_003023628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D513"/>
    <dbReference type="GeneID" id="9582221"/>
    <dbReference type="KEGG" id="tve:TRV_02182"/>
    <dbReference type="HOGENOM" id="CLU_2607747_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="79" mass="9089" checksum="C0799AB958585B98" modified="2010-05-18" version="1">MVLSDTSTSDGARTSSIENKTSNHGEKMSDYLKRETSSYPERNTKRKKKNKENEKLLTNLPTRQKMMEFTQCEGNIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D557</accession>
    <name>D4D557_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_02227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023652.1">
        <property type="nucleotide sequence ID" value="XM_003023606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D557"/>
    <dbReference type="GeneID" id="9582198"/>
    <dbReference type="KEGG" id="tve:TRV_02227"/>
    <dbReference type="HOGENOM" id="CLU_331558_0_0_1"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="400"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="864" mass="95201" checksum="FBBF3D0B0B0EE96E" modified="2010-05-18" version="1">MTPEGHLRSVKAIRDKRRRITKLDFVHSSSSFKFEQHRTQDMEEKSRKLKVEDEEEQLQLQLQTSSRTDIDTLEERPHSTTLQLQTTRRTRRIQKARATFREVENNYTPGSPNMASSDAAQTDPLLALKRALSSSSSGPVLTNSPELSTEHATDDISKATHLYLTQPIAQSIPLSTPTRFVSAAADQAIDLRSIYFAWLKKDVAIPEYIASAQEVNDALGSAGKVLNLVFVEKVDLISWLEGASDESEYIKPLEGKEAGEAAGEAGDAAAPAGPAAVSAKEAADVAASSVPAKAAAGAVGAGPSTSRAGKTVDARLQAIYNGERKLGDRNTVLRGIKPTDFSHIRKTAELFLGRNRSRAAVSSKGGKPTPTPGPGSIPKKPLDPTATPSGTSSASSSSRRPNPIILVSPSASSLLRMSNIKTFLTEGIYIPPDHPSLAKSTNSNLLHLSRALQTIPDTSRSATAPAGAGVTAGAANTLRKPTLFILVDSTADFKPDYWNRVVAVFTTGQTWQFKSYKWSTPQELFKHATGIHVGWRGEEPPREVKGWGRGVRSFAIDRWDEKSANVPGGGARWRDRGVVEGIWSAIEEGMRARGWQAGNYFCIFYNFVYLFLFGGFGFVHACICTVTFPIISVIIRSPFWRTYIAAVSMYVRYVPIAGSDYYIPHPTPGVMSTWQAAKGGPSQPTRRSKKGGVASAEFASHEAPEEAKRAEHGFFLYFSFFFSWAAIDRRRSQAEAGKVNLGVLRIRKEEEEEREREAYVRVLRLQPSPASPVNPQSPRRASKVVWTWVEEYSPPFAALEMEEKNTSRQKDSSRKEKEKREEERKRGGTGGMQTNEKKKEKEEGDITTKSLKGQKSMKKIRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D570</accession>
    <name>D4D570_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000119">
        <property type="protein sequence ID" value="EFE42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023608.1">
        <property type="nucleotide sequence ID" value="XM_003023562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D570"/>
    <dbReference type="GeneID" id="9582154"/>
    <dbReference type="KEGG" id="tve:TRV_02240"/>
    <dbReference type="HOGENOM" id="CLU_1939643_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="130" mass="14599" checksum="3A7EBA0BFA888083" modified="2010-05-18" version="1">MPPSSPRLIYTWLGYFSAVGAALLAAAAKPGEHYEKLLHDLPAAWLCWVILCIYYIGKRYLLHGRFFDGDGLRGRDLTSFIRLWAASIAVVAFIFASSFSGEASWLLVWKHDLSKTPSPHSTIFLRTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5D4</accession>
    <name>D4D5D4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02304</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000120">
        <property type="protein sequence ID" value="EFE42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023557.1">
        <property type="nucleotide sequence ID" value="XM_003023511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5D4"/>
    <dbReference type="GeneID" id="9577029"/>
    <dbReference type="KEGG" id="tve:TRV_02304"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_2_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="371"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="137"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="781" mass="85541" checksum="AB735E63D85E0228" modified="2010-05-18" version="1">MSRHRVKNISYDDDDLDDEIDDNDDELSPEDREQMRLATIEVQQLLRSQIPAIEAKEDDIWETLWHYYYDVDKSVDYLTKKYRSQEKKETKAKASTAATKKKNTAAIANLLTFYSSSYRFASVNFTTALLEPLFWGSPSSEQPGKMSKLAALAAARKKKEAERQKAQEQAETGGSAEETNKPLSLRDRLAGGGKSRTPAPSSSRSSTPLRGLSRSPKNEQPQAIGDGANIGQRLASKETQQEHASREADVSKSEEKLAAGPSDFAAIIIGERSKLGEPASSVSPRAYNLFDFVVQDLTEVYNFAEPSPDDVVINAQNAAKEKKAKRNANQQAAGKAQTDLAGGVQQLSVEPVKVKSKNLDVLEEHRKAKRKKAVNFVVIGHVDAGKSTLMGRLLYDLKAVDQRTVDKYQREADKIGKGSFAFAWVLDQGAEERARGVTIDIASNNFETKDTKFTILDAPGHRDFVPNMIAGASQADFAVLVVDASTGKFESGLKGQTKEHALLVRSMGVQKMVIAVNKMDIVEWNKDRFDEIEQQISAFLVTAGFQAKNISFVPCSGLQGDNIARRCEDKKAGWYTGKTLIEELETSEPFSYALDKPLRMTIGDIFRGGIQNPLSISGRLDAGHLQMGDQFLVMPSGEKGVVKSLEVDHEPVDWAVAGQNVVLHLANIDAKHLRIGDIVCSAASPAQNITSFTAKVLAFNHLTPMHIDVHRGRLHVPGRITQLVATLDKGSGKPTKRKPKIVAPGNVARVVVDLEQSIPLEAPARIVLRSSGETVAAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5J0</accession>
    <name>D4D5J0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000121">
        <property type="protein sequence ID" value="EFE42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023510.1">
        <property type="nucleotide sequence ID" value="XM_003023464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5J0"/>
    <dbReference type="GeneID" id="9583530"/>
    <dbReference type="KEGG" id="tve:TRV_02361"/>
    <dbReference type="HOGENOM" id="CLU_042688_3_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="292" mass="32968" checksum="40FE090A25ED0EDD" modified="2010-05-18" version="1">MSATATTTTSDPQVVLENDVNHIPRGDVEAPMQFFEYPEDGSEPYNLMEGHLKGGTQPNYPLSTRTISITDIRGKESEYSLAKHGFQGVSNVPSAADPSFCDEENIKSVWYPEVEKFVGELFPEAKRIFIFNHIVRRSQPGAEHSPLISAHIDQTLTSTKEAIGLFFPPEEVAELLKDRYRVLNIWRPINGTVQSYPLAVAMPSSVPDDDLVRIELRYPQHKSETQMLKYSPAHKWYYWSGMTNEDRLAFMIMDSKEDAVARRTAHASFADPRTPAGAKPRESIETRVFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5L8</accession>
    <name>D4D5L8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho2 GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000122">
        <property type="protein sequence ID" value="EFE42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023496.1">
        <property type="nucleotide sequence ID" value="XM_003023450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5L8"/>
    <dbReference type="GeneID" id="9583516"/>
    <dbReference type="KEGG" id="tve:TRV_02391"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15446" checksum="F7F7FE61B8FEBB41" modified="2010-05-18" version="1" fragment="single">LALWDTAGQEDYERLRPLAYSKAHVLLIAFSVDTPDSLENVKHKWIEEANERCPDVPIILVGLKKDLREDPLAIEEMRKKSQRFVSPRDGSEAAAEIGARKYLECSSLTGEGVDDVFEAATRAALLTFGKTRGPCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Q1</accession>
    <name>D4D5Q1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_02424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000126">
        <property type="protein sequence ID" value="EFE42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023440.1">
        <property type="nucleotide sequence ID" value="XM_003023394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Q1"/>
    <dbReference type="GeneID" id="9583460"/>
    <dbReference type="KEGG" id="tve:TRV_02424"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="77"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="411" mass="46788" checksum="8C37C984980BB0E8" modified="2010-05-18" version="1">MATTKMIKQLLPDIAHAKEQQQQQQQQVLEHDHVEAEVKPDRLSWPASRPRTPKDVVQARLKQDAGLPDNGLTIDDFDLIKTLGTGTFARVWFARLKAAKEPNKNIFALKILRKAEGRLPDPSPNYLRSVIKLKQVEHVRNESKCLSKAAGHPFITTLITTFSDEQCLYMLLEYCPGGEIFSFLRRARRFDEYTSKFYAAEITLVIGYLHDMHGIAYRDLKPENILLDQEGHLKLVDFGFAKQLYNLETYTLCGTPEYLAPEVIHNSGHGLAVDWWALGILIYEFIVGQPPFWDSNPMGIYEKIVAGCIRFPANMPASAKDIISALCKVNPSERLGHISGGSQRVRDHPFFEGIDWDDLYRKRVKGPIVPQVSHPADTANFEEYPDPPDPATQAVYTDEMKARYEEIFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5X2</accession>
    <name>D4D5X2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_02495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023393.1">
        <property type="nucleotide sequence ID" value="XM_003023347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5X2"/>
    <dbReference type="GeneID" id="9583413"/>
    <dbReference type="KEGG" id="tve:TRV_02495"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="525" mass="59536" checksum="B6B8BAB7F397D71C" modified="2010-05-18" version="1">MSMDLDAPVSMQPVEFHPQQQAATILCCNCGAPIDGTTAAGALCEDCVKLTIDISEGVQREATLHCCKDCERWLQPPAQWISAALESRELLALCLRKLRGLAKVRIIDAGFIWTEPHSKRLKVKITIQQEAFQGTILQQAFEVEYVVASQQCPECAKSYTVNTWRASVQVRQKVPHKRTFLYLEQLILKHGAHKDTINIKEVKDGLDFYFSARNHAEKMVDFLASVAPIRVRKSQQLISMDVHTSSKSYKITFSAELIPICKDDLVALPIKLARSLGNISPLTLCYRVGTSINVLDPATLQTADIPSAIYWRSPFANLADIQELVEYVVMDIEAIGQSSGRYHLAEATVARSSDLGVNDTTYFARTHLGGILHPGDTVMGYHLTGTNFNNANFEEIEASHTYGSTIPDVILVKKHYPRKRKNKKRNWRLKRLDREEEDERPSKKQNNNNRLEDDFEMFSRDVEEDAELRSTLALYKAKHNQKPKNVEADAMEMVEEEEEEEDDDEVPEINVDELLEDFEELHVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D5Z7</accession>
    <name>D4D5Z7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000129">
        <property type="protein sequence ID" value="EFE42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023418.1">
        <property type="nucleotide sequence ID" value="XM_003023372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D5Z7"/>
    <dbReference type="GeneID" id="9583438"/>
    <dbReference type="KEGG" id="tve:TRV_02520"/>
    <dbReference type="HOGENOM" id="CLU_054430_0_0_1"/>
    <dbReference type="OrthoDB" id="4168687at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="327" mass="37324" checksum="5AA276BEC1E9CF55" modified="2010-05-18" version="1">MSRPRILLAFFHADRAPRNCILTPNFYSHRTDRQQTRFTSTPFSPAASIAKTIPAGTELIGQSGRHYIIEKVLQAKENSPLHVYLAKCVHALKNPSFHEANSCLFDRSEKEDFVLKNVPDFEYLQKVYQKVDGCSYLRLPQDSMAERSMFVYRYLTTDFLNLPVKNELPLDTTKRVLRDALQGLAALHDNNIMHNEDGSITDVRLGDLEDAAIVPPGCGISGRQLVDESELGAGEEILAHVIERQISYFADEDSIQEFLELIRESPWAEVFKITSDGFNNENPRKPFALWKGVDPVFKDLICRMTHFNPRKRITARGALEHEWFKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Q9</accession>
    <name>D4D6Q9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_02786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000145">
        <property type="protein sequence ID" value="EFE42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023096.1">
        <property type="nucleotide sequence ID" value="XM_003023050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Q9"/>
    <dbReference type="GeneID" id="9583116"/>
    <dbReference type="KEGG" id="tve:TRV_02786"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="225"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="520" mass="57491" checksum="150783B917F7ADE5" modified="2010-05-18" version="1">MVRPAPPSSPTTNFSPTSRQDRIYKPLNRLDTDQARHLHLQSPLTNRLNHCKHRRHGHYQDPRSFRLRLSRQPNRRGRRRHRDWPPPRHRPIWSFHRFVSPMTSCTLLSSAAIETRDMLTGPAGQHEACELRDGDKSMWLGKGVTKAVENVNTIIGPALIKENIDVKDQSKVDEFLNKLDGSANKSKLGANAILGVSLAIAKAGAAEKGVPLYAHVSDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPSAAPSFSEALRQGAEVYHKLKALAKNKYGQSAGNVGDEGGVAPDIQTPEEALDLITEAIEQAGYTGKIKIALDVASSEFYKADAKKYDLDFKNPESDKSKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFFKTSDFQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSFGADWGVMVSHRSGETEDVTIADIVVGLRSGQIKTGAPARSERLAKLNQILRIEEELGDNAVYAGEKFRTAINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6T3</accession>
    <name>D4D6T3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_02810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000146">
        <property type="protein sequence ID" value="EFE42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023063.1">
        <property type="nucleotide sequence ID" value="XM_003023017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6T3"/>
    <dbReference type="GeneID" id="9583083"/>
    <dbReference type="KEGG" id="tve:TRV_02810"/>
    <dbReference type="HOGENOM" id="CLU_021529_0_0_1"/>
    <dbReference type="OrthoDB" id="4174284at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="763" mass="82985" checksum="BE097B94CBA74E28" modified="2010-05-18" version="1">MNYDSDDARNLSPPLEKQKIVYEPHESPPPFIPEDKSETCSPVDASCSSNNNNNNTSSSSSSKPGGGGPGGGGDRKRRRCGRSTKSALSDELILRSVAPNDPEIAYRSREAPLRRDSSSCSSSSPVSEHTSGAEDAASLQDVDGALPPDIELKRRLQSTSTSAGGAARKPSSPTLISASNNNNHHNNNNSAENNSTHTSTSHRNHHHSHHHSHHHSFGQPLPRPDILMTDPPNPSADPSAAAAAATPRHPATTASSKEGASNAASPAPAPAPAPAATTTTRLPSVAQIISNPTSQSPLSASIFQDSRPPLLTTPTTFKKLNTFPLDPSRGAGGQSLPSTIAGSSSDSGSTVCQSLPSFRSSFPSEIVPDVISSKDHFLNKNGVPPQPPYPAVTSSPRQSHHSHSHSHGHHTSSQSHIRRLSEQFYPTPLLSSTSSTPAYSQGSPPKSCDIPTHHHHQQPPPPPPSQQQQQQQQQQQQQQQHYWPGRLKTDHSRSHSQSHSQSLSQSSCEPGFQYSDSPSTGYPTPTDPASQEGSEKRHATPTSSSIASSGMFKCNYPGCVALPFQTQYLLNSHANVHSQFRPYYCPVQGCPRSEGGKGFKRKNEMIRHGLVHDSPGYVCPFCPDQRHRYPRPDNLQRYVTKPKMKKKKKRKEGRSNRSFSALVLRFLVDPALSVVACSSLPLRLLCLRQALIQHFTLYYPYITPNALSIICNVAVLTFSPLFAFALNRHVRVHHIDKDREDPLLREVLAQRPEGANRGRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D793</accession>
    <name>D4D793_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_02974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000152">
        <property type="protein sequence ID" value="EFE42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022892.1">
        <property type="nucleotide sequence ID" value="XM_003022846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D793"/>
    <dbReference type="GeneID" id="9576930"/>
    <dbReference type="KEGG" id="tve:TRV_02974"/>
    <dbReference type="HOGENOM" id="CLU_028537_0_0_1"/>
    <dbReference type="OrthoDB" id="5348845at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE42274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="635" mass="71066" checksum="69DC19CA3F77A965" modified="2010-05-18" version="1">MVSSFVATTLAVGHNAVKSILFRIAGLCLQVGVFKFFALIASVKNAFTAYLMFTEDYIQRTLFVFSRGFTHQAVIVFSFTILLLTSGLYDTLLWGLDSPGYIPLKRNVTASTLKDQLLRRPGYVVFFSTRPEDFDTLDRHFADSMNGNLFQSHLNFSLTGNVDLGKPEPVPPTQKFNLQKNIGPRIWLDSEGFSVSPDTYVTTSSISNLERKEYYTCPWVTVTEGESASWECSFDNIHAGQFVRTPLGQPEIHWDDVTDQNHLSEYMRPNREDNPWSFLGSGGDTAMMKQMFTVTKGRRRHTFLENVMKVSAVYDHNQPFPRDSVHDLVKRTWSLDPSQWDDPYITKITEKIRHGVSNNTSFQFGSVQKSGNNTVLQFHYEYLNLVATESVVVFSLFRISLINITIIRSETLPEPVKPLEACDHYYHNRATGGKVYGTSCYEQGSSNKTGARFFGQIDSSSVLVIGGTLGDGSTNVSSVALNQKGFQWVANNTEKLDNFVLSRGYIMAIDPGLVTLETSRVQAAMSPLQVLLVILPIIFCAAIWIWLWLQVDPHYSSSLLANLYATTNVGDTNTSADPGYIHTMPDIGLVKKDGKVQMATSTGVFIHNHSETVGDVGIEHQQTDPRGHYTPIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7J7</accession>
    <name>D4D7J7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022783.1">
        <property type="nucleotide sequence ID" value="XM_003022737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7J7"/>
    <dbReference type="GeneID" id="9581518"/>
    <dbReference type="KEGG" id="tve:TRV_03079"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52815" checksum="C7E7AF35E0BFA794" modified="2010-05-18" version="1">MGLSAESSAQQIEAQDVEKAVEAIPISSFAEIPSEKGGSQTQSGSSSDHDNDVNQISKVPTKTVERPGVLEKTLSLVRTRESNRDPGPPPDGGYHAWLQVALTHMVIFNTWGFVNGFGVFQSYYTEALKRSPSDIPWIGGTQIFLLFFIGTFSGRATDAGYFKAVWSAGAVIIIFSLFMTSLCKTYWQTFLSQGVCMGIGSGLIFCPSVALLTSYFARRRSLAIAITASGSATGGIVYPVLVQQLLPIIGFGWTMRVIGLITAVTLTPGFFFLRQRIPPRRTGPFFELQAFREPAYSLYAVAMFLNFWALYIAFFYVGSFGRNVIGLSQKDSINLILIINCVGIFGRLIPCYISDWKSGPINALIPCTVVAGATLFGWIGVKREPNLYAFSIVYGFFAAGIQALFPSALTSLTTDLKKSGIRFGMTLSIVSFSSLTGSPIAGALIALRDGDFLYAQIFAGLSMFLSLAVLLLSRSKVVGWKLKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7R1</accession>
    <name>D4D7R1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorbitol/xylitol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_03145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000161">
        <property type="protein sequence ID" value="EFE42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022763.1">
        <property type="nucleotide sequence ID" value="XM_003022717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7R1"/>
    <dbReference type="GeneID" id="9581453"/>
    <dbReference type="KEGG" id="tve:TRV_03145"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="240" mass="25487" checksum="4AD2BEA58A86B12F" modified="2010-05-18" version="1">MVFAATPPYDGTLAKYYVLPEDFCYKLPDTMDLKDGALMEPLGVAVHITRQAEVKPGDTVVVFGAGPVGLLCCAASRAFGAAKVVSVDIQEERLEFAKKYAATGVFLPQRIPAKENAEKLRSEHGLGRGADVVIDASGAEQSVHTGIHVARPGGTYVQGGMGRDEISFPIMAACTKELNMRGSFRYSSGDYKLALDLVGSGKISVKELVTKVVAFADAEQAFLEVKAGKGIKTLIAGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8G8</accession>
    <name>D4D8G8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022454.1">
        <property type="nucleotide sequence ID" value="XM_003022408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8G8"/>
    <dbReference type="GeneID" id="9581001"/>
    <dbReference type="KEGG" id="tve:TRV_03404"/>
    <dbReference type="HOGENOM" id="CLU_101425_0_0_1"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="18406" checksum="E6B1B19E37BAD588" modified="2010-05-18" version="1">MLTYNQNGTSRGIASIIFSRPETAIKAAKELNGLLIDKRPIKIEVVVDASRAPPVPTPKPLTERVAQPKSQPKPASAAKAGRKRDARGRTQRGRNAGRPKSKTLEELDAEMVNYFAEAPASTNAPAPAANGAAPQPAGNGEDLGMVDEISVSRWFIPVLFKYYPNANVVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8I0</accession>
    <name>D4D8I0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000177">
        <property type="protein sequence ID" value="EFE41848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022466.1">
        <property type="nucleotide sequence ID" value="XM_003022420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581013"/>
    <dbReference type="KEGG" id="tve:TRV_03416"/>
    <dbReference type="HOGENOM" id="CLU_254978_0_0_1"/>
    <dbReference type="OrthoDB" id="4173589at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1309"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1400" mass="152156" checksum="D55A8B3D8CF1A0E0" modified="2010-05-18" version="1">MAYNGYGYPQYQHTNSRAQQSQTPYAPPSQTPKPAAPAPENRSQDYGQQNNSWNGQNVSRQQTSSQQNVRNSYWLSPANNTASQPITYQQQVSYRMSGTNQTTTAHQYNNQAHSLGGTNTHVIDNYGGESNPNIGVRRDMVNSGARYTSSPPQGQAAAIPPVTTSQNPQSYQSTTPSHQSDYMQNPRTVAATAMTALSTAARRNYTQNAPAASANSYQVSNSARYNASAGDPTGHSPATNTSSSSNTYQYQTTNPGQVIEAGTATSNSLNQTSNTSDMSTHSVTSSAEPSPQLQHRVHQTKPATSRSPTLFQHPNRTSSSSQIRRPGQEFSMNTAKPDNGRPSPAMSQRPYSQPTDTSSVTAESPTQNSLPRFVDPTNIYNPYYGQFGTSGVTNTAHASVEPDVTSVTGGIEGIQVETQQNSTQPPAQNATPSEVAPNTTVSNVATNALEASITKEASKGTPQGVSNDAPKKARKRPNRKQKPGTASAPISPSTQPQTTSTTQEEANGKEDTATQMQRMLDEMRKKDPDLFKSILAANMGKQESSGQTAPQVPSKVDNTSAKTYIEESSIASSSQLPPPHSSNNLPKKKARNKRATGDAVFLISTPAQKGASPSIINNNNMSTENTQAEQHHHETALPSTRPSQTQNIKTIIPEQVAKPGFIDGLPDLGKFPALRRKRRLKASLTANESSPAPNSNLGLENEISAAHLSGQPVPAPEAPTSVPQPYASLSVEEQRLSLLDNFTKTGHAEFPQSPNIPPSSTEDIQLTQEGHPRTTLDAPLPLQGQSQPAGDEVGKEERMTSFWPDQKRRLLAESACQYISTFPGNDSITSDFISSLIEQNPSYVQLCNMLEGHGYTINKVHFAKHLLKTFPDLGESSNKETKATSEPAMQTSQPSLPDSSFVSSTPADPIQIAIPQQNLEVTALQPGSVPSKSVSALPLSREKQRQKSLNLLHISKRRRKSAPQHRSSISASPAPQPREPFPNSKEAMARKRTFAEIVDLSQAISDEDESEAEDEVLDQPNLLEIAVEDTMNTSLDVTMEDAINVTPVQRNTPEILPQCPSEDRKVVPSVQKQLVRSREPSPAVQPMPEKPTSMAKPKHVDATPQPTGKEDLRRYNGIVKPMNKAKALKRSYYDPRTIARDILIAAGRHPTERSLNYHLLKLKENFQFVDYTSDLETFRWDLVDPGGPPPPKIAPEPLLSQPKSHSRDDSISRDETSAGRRFQSERGPSQLRISHTVNTDSSSTPPRPMAPTPQKPTFASSLPTRRRPGRPPGAKNKPKAIPSVASKVEVAVPRATPQYPSNKYPIYECGFDGCGAKLHNFEIFRKHVLKLHSQSGEEQAICRWTGCASGEAAPRIFSTEGLKQHLDSVHLSPLAWKLGDGPKSVSSGETGKFHLPIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8K2</accession>
    <name>D4D8K2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000179">
        <property type="protein sequence ID" value="EFE41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022436.1">
        <property type="nucleotide sequence ID" value="XM_003022390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8K2"/>
    <dbReference type="GeneID" id="9580983"/>
    <dbReference type="KEGG" id="tve:TRV_03439"/>
    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="38913" checksum="7F0FC11A2AFDA398" modified="2010-05-18" version="1">MLEYRTEGFNGCAVKYSPFFDSRIAVAASSNFGLVGNGRFYILNLTPQGILPQQSYTTQDALYDVAWSEIHENQALVASGDGSIKLFDIAVNEFPVQGWKEHSREVFSVHWNLVAKDRFSSSSWDGTVKVWTPDRPQSLLTLPTNSCTYSAAFSPHSPDILSCVASDSYLRVFDLRTPAATNHLTLQMPIHGANSPHKPGFTPATGPVPPSEALTHDWNKYRPSVVATAGVDRTIRTFDIRAPHQGPLSAMIGHEYAIRKVSWSPHLSHVLLSASYDMTCRVWTDGSEGMPPGDADLTRSGPISTIGRELGRMGRHTEFVTGIDWCLFGSEGWCASCGWDERLCVWDARAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8W2</accession>
    <name>D4D8W2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_03550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022339.1">
        <property type="nucleotide sequence ID" value="XM_003022293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580886"/>
    <dbReference type="KEGG" id="tve:TRV_03550"/>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="428"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="716"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1348" mass="149922" checksum="91ED098200498AF2" modified="2010-05-18" version="1">MRNLRNIRFSEVPLLGGLPLAATAWDASTDSLICAFGPAEDNAVIELKRKLQHEDANPEALPGDMSLIASWDAPCPNPEMKCDRILSLQYFPDTLIICLVLEGGDIIVVREEPQPGEDKIEIVGSVDAGISAAAWSPDEELLAISTKANTLLYMTRDFEGAADIALSQEDLKISQHVSVGWGKKETQFQGKRAKALRDPTVPEKVDEGKLSEFDDGKNTLSWRGDGAYLALNSIETGIRRVIRVYSREGALNSVSEPVDGLEGALSWRPSGNLIAGIQRLDDRIGVVFFERNGLRHGQFTLRLSKEERLSWASNITLAWNVDSNVLAVQFKDRIQLWTTGNYHYYLKQEVSLSIDGASPLCTFRWHHEKAMRFTASSPSMYSSSILSSVWVPRKLLTSFEASLIDTDWVFEVAAGSTIIPNDFGSTAVIDGCTLKLSPLKVATVPPPMALCELAHDSNIIDVAFSKTSAKIAILSAASFTIYTWNLKSTSPLEATLHSSYAISPSRRPRLIAFLGEDDIYVVTQDEFGGEVVEWTGLQSNASKPVFLPEEGVHISSIFPDSEQEKLWIAHISPSKRVRSYSFVRNNEAEDSSVVTWQEGPATDTSWARAIQVPSGDDILFTLSRSGALYANKRLLTKSVTSFLLTSAHLIYTTAQHLLKFVHIAKVDDLEIPGDTPEEDERCRSIERGAKLITAMPSKLGLTLQMPRGNIETIYPRAFVLAGIRGYIENKKYKSAYLVCRAQMVDMNILYDYMPEQFLDNIPLFLDQVKRVEFIDEFLSRLRNEDVTKTIYKDTLKLSQPTEVSRGNAPGSDQAPATSFGKIKAENKVNKICDAFIAILSHRIDTNLQNLVTSHVCKSPPDLDAGLSLVAKLRANAETERNAEQAEEAVEHMCFLTDAHQLFNYALGLYDLELTLMVAQQAQRDPREYLPFLQKLHGISELQRKFEIDNHLGRFNKALKTLHALGSYDDLKLYTIKHGLYKDALELYKYQPELLWDMTQLHADYLYDQSNYKEAAIAYESLGMFKPAYESYKLAHMWRESLYCAALVPLSETDMNELATSLASTLTDENKDYVSAARIQSDYLHDIPTAARLLCKGSQFGDACRLLVLHNYQDRVSEIVDHGLAEAMGTMTELLADCRSQLQAQVPRIQELRAKRAADPLGFYGGDPTGAGAGDVDIPDNISLAPTDASTMAGRSLFTRYTGGSSTSRASSRMRKREERRRAKGKKGTVYEEEYLVNSVRRLIEKVNSSIEEVEALVQGMLRRGMRERAAVVEKNLDEVLGMCRDCLSDVFETPAEASSDAQDKEDEPPAGAISSGERVYLESMEALKGKGREPPVVKAFKKLSLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D928</accession>
    <name>D4D928_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase/oxidoreductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022294.1">
        <property type="nucleotide sequence ID" value="XM_003022248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D928"/>
    <dbReference type="GeneID" id="9576897"/>
    <dbReference type="KEGG" id="tve:TRV_03618"/>
    <dbReference type="HOGENOM" id="CLU_020884_1_3_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="490" mass="55869" checksum="E058C9C60C6A2B6E" modified="2010-05-18" version="1">MSPQTDLQVSPSGIFKRVKDKIQACLDLKKKHDMQLAELGEPTDSYCYKSTLVKYHCPQTDELHATTDTEAFVNSWEVTNSQFRRLHERFKRLFQSPAVDVTFPNFRWTARVNDIYATWMGHSSVYMEFYWSGLTVLCDPVFEDTCVYRGVKERRLNPPPCKIEDIPFIDIVLISNSHPQHFSYRTIKKIHKIHPFCQFIVPRGCGDWFRENSIDTVTELDWYEKVDFQSLPYANASDTAQIVEAGWEERKDINATIWCLPCQYESPMGPGSRAKGLWAAWLIKSEMCNVYFCGYAPRILSGNYTHANISLTRATGYRTPEDVPPGTDPLFTRVAKRPYTNNRCPQELCRIIGSIRPCIDLACIPIGGYKPRTLWGGRNCDPTDAIMMLEDLGAQFGLAIGYGTWGTTNEESRAVEDEFERACVARGCESGKFNITGIGQTIGYPQTAARGPVDPQSLCENRPEWLKMKLREKRGYDPCCGSVPYRPRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4D991</accession>
    <name>D4D991_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000188">
        <property type="protein sequence ID" value="EFE41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022201.1">
        <property type="nucleotide sequence ID" value="XM_003022155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D991"/>
    <dbReference type="GeneID" id="9579086"/>
    <dbReference type="KEGG" id="tve:TRV_03682"/>
    <dbReference type="HOGENOM" id="CLU_023133_1_0_1"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="49983" checksum="92F94A31031DF02B" modified="2010-05-18" version="1">MSVPDTSPPSWDLTPAISLLHSFSLEGCQHERPASPKQTANGPINHATFASNALGDAESEKGAQPKLGDFGALFTFLSQTTPPKLGTVSDNSATHASSGKKDVLEAAAVLKHQLDGSRSPTKKVILKRDVPKRINSAGLSVLPTPTSGTVLVSPKSILRRPPATTAGAVVAAEAAPAPKGKRIVGSIIHIEPLLTGSTIQRQQALVSLLEEKHAKVRNNLNHGNLRECLCRPLKTAPAGIHVFVDMSNIMVGFHDCIKKSRDIPLTTRVRRLPLSFQNFALVLERARPVSKRVLVGSDRYPAIDEAETLGYEANILERVHKAKPSSPRKTKLSGGGGDKASRRALYDQSSSSETNAQASPERWVEQAVDEILHLKILESIVDTDTPSTIILATGDAAQAEYSDGFLKMVDRALSKGWYVELVSFSSITSRAYTRKSFRDKWGSRFRIFELDIYAEYLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA20</accession>
    <name>D4DA20_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase Rho3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000203">
        <property type="protein sequence ID" value="EFE41316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021934.1">
        <property type="nucleotide sequence ID" value="XM_003021888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA20"/>
    <dbReference type="GeneID" id="9578817"/>
    <dbReference type="KEGG" id="tve:TRV_03964"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12873" checksum="2FAD957BEF368DC8" modified="2010-05-18" version="1">MELSLWDTAGQEEFDRLRALSYDDTQAIMLCFSVDSKDSLENVESKWLAEIGENCPGAKIVVVALKCDLREEASDEKDDGSNTQQQPKPVITYSEGLEVAKRINALRYLGAFTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA36</accession>
    <name>D4DA36_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000204">
        <property type="protein sequence ID" value="EFE41273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021891.1">
        <property type="nucleotide sequence ID" value="XM_003021845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA36"/>
    <dbReference type="GeneID" id="9578774"/>
    <dbReference type="KEGG" id="tve:TRV_03980"/>
    <dbReference type="HOGENOM" id="CLU_018184_0_0_1"/>
    <dbReference type="OrthoDB" id="5244050at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="834" mass="91902" checksum="48A9A14110E5AF07" modified="2010-05-18" version="1">MTLDIPPRMSSAGQHHHHHHQDQRQYRQETAIGIIERAFDSFPATPSPDLALWREHKGGLRETEMETDAAPRAESCASDLTGGYSINRTGRLDEEVDIEPVKEHKVRPRLSSPFLRHVTRKTSSNLKQDSLRPSEPSSSSSTSQAVNRSQKSYHTNGTSSQDLALRDYPAGANQSTTDLSTDHNSRGTSSRKAHNKQKHRPPMIDLSKLFPRQRKTPVPCPPSPVRVDTPPSIMSNGSDTSLYKTHKFEKAQRALDRLTTRSPNSGKLDMIQSEYRQEDDLTPVQAPLDRYQSTSSLQEPFNHQKDQSNQQQQKQRQEKDKLAEDTGERLTDRKYEGNWRDFNYKRKKLDSAWYDGVGHHLVDDDMGIQPGDQVEVMYGQLLSRDPAPATRERRSMSLPSRQPSIQSGKPGHGRLAVPNGSTQKPKTSSGSVKSASMANSNSYSSQPSVNTNSRPAGKSDKEEPRIRKKSSRAILNASNLNESSVLCLSSSEDESEDESSDHTTGLRDSITTIDEGFQICTAKAVTTASRPSIKRVRSSSKKHTARSGTSTATRSQNGDTSSRASSLHPSILSPTDSNFSSGRTIPDRLPTSPPTLPRIQTQFSPAESGLSQPGNRRSRVIAVTRQEEYLLELIRRNKGAVPQTLSPDGSASTNTKEWARALAAQMNRRSASSYSSDTSFLRLSPALPPTPLQKRPPRSIPNPSIASTTGDAASSPSVPQSVTSDTSYHTSFQSPPPLPKINLVNSGVCFPSPPSGQSSPFTPPAVPFKHRRHSSRMSHTPSMPSVRESLRNRANTTAIYDDNDDCEKDIETNPDIPIWALGWNSEATGVAIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN9</accession>
    <name>D4DAN9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021676.1">
        <property type="nucleotide sequence ID" value="XM_003021630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN9"/>
    <dbReference type="GeneID" id="9576759"/>
    <dbReference type="KEGG" id="tve:TRV_04187"/>
    <dbReference type="HOGENOM" id="CLU_122468_2_0_1"/>
    <dbReference type="OrthoDB" id="4173816at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13160" checksum="AFD7C4F950F99A86" modified="2010-05-18" version="1">MPVVWDDKADALLLASILATASAKVDNAAVAKMMGGEYNALAIKNRIARIKLKAKAPSSDTETPANTPQKPKTARPAGEKKRKVKDETETEQSEAADQQAPKKGRRAVKTEVKDEVKEEDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAQ1</accession>
    <name>D4DAQ1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000214">
        <property type="protein sequence ID" value="EFE41070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021688.1">
        <property type="nucleotide sequence ID" value="XM_003021642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAQ1"/>
    <dbReference type="GeneID" id="9576771"/>
    <dbReference type="KEGG" id="tve:TRV_04199"/>
    <dbReference type="HOGENOM" id="CLU_2322047_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="99" mass="11801" checksum="BDD72BD0B3BE8D8C" modified="2010-05-18" version="1">MQLIYIEREVFLYIKNQPDMSRQREFTAQLTKKERRIEPGETSGGRSKCTSKSRPCFLALRAEYQLHQAVAVFNLHLRLLYVFSFGFFFFHLQEKISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAT1</accession>
    <name>D4DAT1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021649.1">
        <property type="nucleotide sequence ID" value="XM_003021603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAT1"/>
    <dbReference type="GeneID" id="9578610"/>
    <dbReference type="KEGG" id="tve:TRV_04229"/>
    <dbReference type="HOGENOM" id="CLU_071858_1_0_1"/>
    <dbReference type="OrthoDB" id="3438781at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056353" evidence="2">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="268" mass="28054" checksum="C23E3BBED4CD8902" modified="2010-05-18" version="1">MRLSSLPLFVWLAATAVTSAGSCSNGYVSCHPKGAELGNPPDIGPDMKDFYVDLVQSVKGHGHGREKRSLNKNHGVIAQRDEEGELCWKGKGNGPGSGIQCLFLDGAKFPFCWVSLLCTPLYAGYPKENTDTFQDPFTTNFFFRDASHGNAATGDYQTGNGDKVNLIHGNYTKPDGTEENIYGAKESAPALSTLPVPTPFTGSGVGSPIPGDKLGNVATSGATAPPTSSTKSPSGSKPTTPADSSSQKMELGFSLVASMAMLACALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBM3</accession>
    <name>D4DBM3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000227">
        <property type="protein sequence ID" value="EFE40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021368.1">
        <property type="nucleotide sequence ID" value="XM_003021322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBM3"/>
    <dbReference type="GeneID" id="9578248"/>
    <dbReference type="KEGG" id="tve:TRV_04523"/>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="641" mass="69467" checksum="48F10D5AAC79277E" modified="2010-05-18" version="1">MPCFKGLAVSIHTPNGPLAEYSVQRHSRASRIACYIPVPPPKLPNSATGKPEQSTFAISITLLTPGLTVPYSTPKATPDNPYPRPKIVGGLPDQPTAGSSIGPYQPMTASPRETVAAYIYFDGRQKEEVATLLRRGEETWVNSRWVGVPQSEGGGLAEREFLFREVGLERWLNGLDLEGKDAAEKIERRRQKMEKRRRKRELQQRNENAANAAADEGMDLDDKKPKLLREKGVLRYGANDQSPVEQLSDDAELLSTDSDFDDDPIPETAGQIKVALFRVLASGEIKRGEYSPQFDAHDDDEDLHGGPGGGQESNGNGSTADIDHTTSFAKPKSLDPKSISTQTVTGIDPTDKPYAVFTFMYRGERQLQKMGILKDPKSQDKESLKSARRKSTQPDFANIKPLKPGGTTGFVGFRDREKEQKTGKRKGSNGNELDSDDDEDDEGVSVSIVGKAEDEEEKEGNSLLSPDDAKRQGELAEGVRQIKLKRQHSAEPLSAAAGLADPAKASKSSTPGSRLSPPVTTRHDSTPPHSSLPKETSMNLLDNDAYVGSPLKKQRASISATDDNVHRQGPVTGLSSKIHEIMDTTATATSATAGETQNSQSSITNHNTSTTTANNDSLGGSLLSEGIMQSDIKSPGLEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBU6</accession>
    <name>D4DBU6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000232">
        <property type="protein sequence ID" value="EFE40666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021284.1">
        <property type="nucleotide sequence ID" value="XM_003021238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBU6"/>
    <dbReference type="GeneID" id="9578129"/>
    <dbReference type="KEGG" id="tve:TRV_04597"/>
    <dbReference type="HOGENOM" id="CLU_030892_0_0_1"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49877" checksum="9594D0BC0C3D0A57" modified="2010-05-18" version="1">MDVDESPRKAQDELEDEAMENSPPALDEDGDMGLFGSGDEEEDEEDVQDRRRKLDDVELDSGDDEGRYDRAGSPMEEDAMDYGRTLNIMDLSLGRAPEPETTDGQLFNCAIPNFLSIESEDFNPETYVAPPFSSASTSLCWRTSPDGSELQSNARIIRWSDGSMTLQLASNPTEQYRISSKPLAQSSRPGKREEYDPDLESHTYLGVAAEASSVIRLTSRITASLSILPSTVETDDAVQRLQESLAAASRSGKKTADGSVAIIEVKQDPELAKKQAEQAEREKLREARKRQAAAEREVDRGRRSTAFQRSGAAGLTIAGLEGDEDMGVGTKSRPGAKRPGARKPRRRDEIYSDEEDDYDRRGRTREDEYDEDDGFLVGSDEEPEIEEDEEEEEEEAEDEDMDAEGEIDDDVQPAKPSGKSSRPQSPGQKEASPQARKKHRYVVDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC89</accession>
    <name>D4DC89_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TRV_04741</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021127.1">
        <property type="nucleotide sequence ID" value="XM_003021081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC89"/>
    <dbReference type="GeneID" id="9577969"/>
    <dbReference type="KEGG" id="tve:TRV_04741"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="295"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFE40509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="738" mass="79815" checksum="5BE948D42213F08D" modified="2010-05-18" version="1">MSALDSWEDDPAAQDENLSKEAQQSLNLNQAPQAQQQQQPSFRPQVASFQPGAATFQPGAASFVPGQQFQQYGGYQQQYYPHAGGYGGYPQQQYPQYSQHYMQQPGGYQGGYQSGQHAGYNQGFNQYQQQAPPPQQEQWQPPSTAEKSNPAPSDATTDATTDATTDAAAAAATPKPTPSESSKPSPASQPPKAKVLTIGGDIPKSKAPAASATSATEAQKSTGPAAAAAGAKVTATKAIEKTEKKGASSPTPSSGRSSPGRADSKAANRDADIVAKEQAADVDEATLKEIYGEKREHVNLVFIGHVDAGKSTLGGSILYCTGMVDERTMEKYKKEAKDAGRETWYLSWALDLTNEERSKGKTVEVGRAFFKTSGDTPDGPMTRHYTILDAPGHKSFVPNMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLARNSGVKKLIIAVNKMDDPTVEWSKARYDECTTKIGKYVEALGYKKSDLHFMPISAQKTIGIDKPVPKDIAPWYDGPGLLPYLHNMKMPERKINAPFMMPISAKYKDMGTVIEGRIESGVLKKGSTCILMPNRTEITVTALYGETEDEIQTATCGDQIRARLRGVEEEDILPGFVMCSPKRPVHCVTAFEAKIRILDLKSILTAGFNCVMHVHSAIEEVTFAELLHKVQKETGRKSKKPPAFASKGQTIIARLEIASGGSAVCVEKFEDYNQLGRFTLRDQGQTIAIGMITKLITDPTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DC99</accession>
    <name>D4DC99_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000241">
        <property type="protein sequence ID" value="EFE40519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021137.1">
        <property type="nucleotide sequence ID" value="XM_003021091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DC99"/>
    <dbReference type="GeneID" id="9577980"/>
    <dbReference type="KEGG" id="tve:TRV_04752"/>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_1"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="272"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="446" mass="49683" checksum="383BF33105A0CA86" modified="2010-05-18" version="1">MIADLQRTEAVKGALPVGQNSPQKPPFGLYAEQLSGTAFTAPRHENLRTWLYRIIPAASHRPFEEVDASTYHTSLSKDATSLRQIPNQLRWNPFDLDEKVDWVRGLHLVAGAGDPATKHGLGILLFAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRILVRPNEICVIPRGVRYRVTLPEGPVRGYICELYQGHYQLPELGPIGSNCLANPRDFQAPVASFDDEEEPSEYTILSKFNNTLFRATQPHTPFDIVAWHGNYYPFKYDLGRFNTIGSISYDHPDPSIFTVLTGQSDHPGTAIADFVIFPPRWLVQEDTFRPPWYHRNTMSEFMGLISGDYDAKTAGGFKPAGASLHNVMSAHGPDAASHEGASNAELTPKKVGEGSMAFMFESSIFLRSTANVLTSCLMIGVSEWGLKTCQKVQDDYNEESWTPLKRYFKNPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCD9</accession>
    <name>D4DCD9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021119.1">
        <property type="nucleotide sequence ID" value="XM_003021073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCD9"/>
    <dbReference type="GeneID" id="9577961"/>
    <dbReference type="KEGG" id="tve:TRV_04792"/>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="267" mass="30957" checksum="2DDE60C250F58E96" modified="2010-05-18" version="1">MEAHEYMQKRLANAPTRIGLKMYPPTLSMTVYKLPFGLYLRRGSPSLVPKYHVEAHTLKMIEQSTNIPAPRAIDVTQTSRYSYLLMTCVPGRPIGPSMNTMTDEEVEQVVVDLKGYISELRKIPRDPSSEYLICNSQGGGFLDWRIPDSQSEELRFKSEADFNKYLTDPFWEEIRTRAAKSHEIPHEIVFTHGDLNPRNILAENGRITGIVDWENAGWFPEYWEYTKMHYTVRGVERWLVDVVDSVFTGYRQELWVENMLSDLLGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCG4</accession>
    <name>D4DCG4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000246">
        <property type="protein sequence ID" value="EFE40449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021067.1">
        <property type="nucleotide sequence ID" value="XM_003021021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCG4"/>
    <dbReference type="GeneID" id="9576714"/>
    <dbReference type="KEGG" id="tve:TRV_04817"/>
    <dbReference type="HOGENOM" id="CLU_455581_0_0_1"/>
    <dbReference type="OrthoDB" id="4174025at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="651" mass="72332" checksum="D70C4E920C6EECD1" modified="2010-05-18" version="1">MEEENQRPKDMTPETWALVEDLFPRSLNRSSAHPHLPSSSGHASDMATYDGSEAAASDGDQSYSVVDGISSTSETPSLLTPPLTNTDDEEFEDIEDEYEDEDGSSVATPSGWGSTPAHSVDSEHDQEVYDHDEYEDESEEEEASEEESEDERNYVQSRGVDWPESTSNPAQFDRVEQQNNHNGVPRHHPCSDATHIFDEPESYDDHETNHHDEEMPGDESREAPANTSPQNTPSHLAQTHADVLRRAIETITQQNEMISALSQSRPAYTQPGAVPGQGKPKKKEGKQKLPRSQGFSNRLAQLMEKYPDIFHVLVLVILSLVATALTFPYIDTCLGISTQVQEGAVTGRVQTIITPVATPVICAKTPVVSTSPEGVQYFESHSRAPQNMDDFITQLTCAKAQGMSESDDVQVHVVGDHHMVVRLPNRLVSVRDGNKFDIKVTRENNGLPFDLYKLFDGVFTLRLAPEDAYGPMNITVSALSKPKLTKVTGVDFGTPWLKIASWKRATQSLSQTLRGDLADAKTGLSKVYIKLTFDFRSMYDAWGMYTNKTSADATSNRISNLFDRAVSRAKKSVARSREASDGFFKKAKESLRQSSDQLRAEAQLMRRKARRSASSMMSAAQERAQQLRAPAFSFDLKAKFRDLRKNLTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD48</accession>
    <name>D4DD48_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_05055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020829.1">
        <property type="nucleotide sequence ID" value="XM_003020783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD48"/>
    <dbReference type="GeneID" id="9577600"/>
    <dbReference type="KEGG" id="tve:TRV_05055"/>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE40211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="865" mass="98721" checksum="BCB462F47512B358" modified="2010-05-18" version="1">MSPTQDTLFRSADMSLTQLYIANEIGREVVSALGELGQVQFRDLNEETTAFQKTFTNEIRRLDNVERQLRYFHAQMEKADIEMRPSEEFSNNLAAPMASEIDELAERSESLEQRVSSLNESYEALKRREVELIERRWVLREAGGFFDRAHGQTDEIRQSFDNDEAPLLRDVEQQPPRGQNGDAHQSSFSVMDIGFVAGVIPRDRIGAFERILWRTLRGNLYMNQSEIPDPIVDPATNEEIHKNVFVIFAHGKEIIAKIRKISESLGANLHAVDENSELRRDQIHDVNTRLTDVGNVLRNTKNALDAELTQIARSLAAWMIIVKKEKAVYHALNKFSYDQARKTLIAEAWCPTNSLGLIKSTLQDVNDRAGLSVPTIVNQIRTNKTPPTYMKTNKFTQSFQLIVDAYGTSKYQEVNPGLPTIVTFPFFFAVMFGDFGHAMLMTMLAITLILFERKLGKTKLDELSSMAFSGRYIMLMMGIFAMYTGLIYNDIFSKSMDLFQSAWSWPEDFNENETVFAELKGSYRYPFGLDWGWHGTDNNLLFTNSYKMKLSIILGWSHMTYSLCQSFVNARHFKKPIEIWGNFVPGMIFFQSIFGYLVFTIIYKWSVDWNGLGLPAPGLLNMLIFMFLQPGRVDDELYPGQATVQKILLFVALIQVPILLLLKPLYLRWEHNRARALGYRGLNEAAHTSAVDDDDEHQNLISGQRDSMGDGEEGIGMVTQDMGEGEEHHEFEFSEEMIHQVIHTIAADLIILEFCLNCVSHTASYLRLWALSLAHQQLSSVLWSMTLGNAFLQTSPTLRVIMTVITFYLWFVLTISILCVMEGTSAMLHSLRLHWVEAMSKHFIGDGIPFTPFSFEAILQEDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDS1</accession>
    <name>D4DDS1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small nucleolar ribonucleoprotein complex subunit Utp14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000271">
        <property type="protein sequence ID" value="EFE39988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020606.1">
        <property type="nucleotide sequence ID" value="XM_003020560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDS1"/>
    <dbReference type="GeneID" id="9577305"/>
    <dbReference type="KEGG" id="tve:TRV_05283"/>
    <dbReference type="HOGENOM" id="CLU_003783_0_0_1"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="981" mass="110550" checksum="01828AAEEB91433C" modified="2010-05-18" version="1">MSGRKSNILKPQEKRSKSATKRRPKNNLNALATAEKQFPTKTKIRRHRLGDDEFSQPTRKRVINDEEEDDDEDAGRAKRVRRDQDGSDIDGGSDSEGNEWRIGTVDSDNDSDIDSDEAMGESDEEKFEGFTFRGSSAMQKKDHSMKAAQAQKRKTNTNQFDRDDGDILNEEFNGASDEEAEEEDDDLGEDAVDLATAWDMNEEDSEAEASRRKASKEKRKQVDTMSEDEDDNGSLSAVSDDDEEDDDDGESDTSELSISDNEGDTKQGLTKLRRFVTSLGQDSGSATSTRPKTALPGGDPTEFGLAPSRKLTVADLMPSISDSRMKGALKHIENDLSTKGTTGIPRKLDVPLPKRQQDRLDRAAAYDKSKETLARWIETVKANRRAEHLSFPLPEPDALQPSKVVDSKPRTNLETTIQNILVESGLADSNNGDAEDKIQEFEELQAKKISVEEIQARRAELRKQRDLLFREEIRAKRIKKIKSKAYRRVHRKEREKLEQMEHEALAAAGIDMDEENRERNDRIRAEARMGSKHKDSKWAKSLKQTGRTAWDEDARTEMADLARREEELQKRIQGKRIVDEDGEFLSSSSEDEDDSDSDMPGFKLREKVDKLERDGTDPKDSGPYSGLLSMKFMQNADAARKEANERELREVKRQLNSEESGSEEEDLQEEVGRRKFGTQSTKSSNKPSVNLSQKEDEGGQARNEGAENASSSDSDIDIRVTPKPRQQSKAAPKKTARHGFEGTKQQSPEDDENPWLAETSKKNRSKKKTIGTAADVGLIENSGSIVAQEPKQQLSRQGYQNGSEKAEVANRPVDDDERSDDEDKATMPVLLQNEELIKRAFAGDEVLETFRKEKKKTVEEEDDKVVEDTLPGWGSWAGAGLSRSDKKRVKRTFTTVKGISADKRKDAKLDRVIINEKQVKKNNKYLASQLPHPFESKQQYERALRLPIGPEWTTKSTFQTATKPRVMIKQGVIKPIQRPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDX7</accession>
    <name>D4DDX7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000277">
        <property type="protein sequence ID" value="EFE39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020572.1">
        <property type="nucleotide sequence ID" value="XM_003020526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDX7"/>
    <dbReference type="GeneID" id="9577271"/>
    <dbReference type="KEGG" id="tve:TRV_05341"/>
    <dbReference type="HOGENOM" id="CLU_1566706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="171" mass="19239" checksum="ACB01ABE18C953F9" modified="2010-05-18" version="1" fragment="single">MAVGDGSSQTDILASNRSTGEGRSACLFQGRLREGKEEGVCVITEPEHTDTTYLHRISYTTVLIIIPTTSSTSLLLLLLSSSLRRKENFLLFKRTKKTSVPRDLVPNGLARPSVLPLRSFEVERSKVDDDDDEQRTATKTSDDDKRRRRRRRSEETRTTRADLLGAALDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDY3</accession>
    <name>D4DDY3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000278">
        <property type="protein sequence ID" value="EFE39942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020560.1">
        <property type="nucleotide sequence ID" value="XM_003020514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDY3"/>
    <dbReference type="GeneID" id="9577258"/>
    <dbReference type="KEGG" id="tve:TRV_05347"/>
    <dbReference type="HOGENOM" id="CLU_071675_1_0_1"/>
    <dbReference type="OrthoDB" id="4170578at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="335" mass="38952" checksum="8DBADD15864A07FD" modified="2010-05-18" version="1">MRKVPSLTPLYHSTLPCKSKGCSPDLSSVAVLVLPVAPLSHPPRTKSAPPKHLLLPTTSHHHDKLHDILYFLQHSFFYLNKQNHLYLLLTCLSPKSASIMTLDPRLLSIPSARPTPGPMIPYQHQYQQESSRNRYGSPESGNVFLPRRILAAIPQDVVHATNIARRRADEAYRGFLFLQHGFNQRFYRLCPNEPRVRASNHAKSIDMLFSWGPKSGYTADPPKIPTCAVKFYVEEDAYLKYAHRYRSYRQKYLNGAYLAWIKSDIFLRNFADNTPMSALTRARFNSWWTGYRDEMRAWEEQIDSLVLPSWASIIRELREIIEQRLDLDKEWDRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ5</accession>
    <name>D4DDZ5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000280">
        <property type="protein sequence ID" value="EFE39932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020550.1">
        <property type="nucleotide sequence ID" value="XM_003020504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ5"/>
    <dbReference type="GeneID" id="9577246"/>
    <dbReference type="KEGG" id="tve:TRV_05359"/>
    <dbReference type="HOGENOM" id="CLU_2580510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="81" mass="8804" checksum="3B8C5BE83940DC29" modified="2010-05-18" version="1" fragment="single">MKEYDGCFGVPVEALASLDDFFEEFDLTILSLLYSSDSEADESRLPRGIVLCLGFPCPDEAPVGGMGILEEDIMISVVDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEA5</accession>
    <name>D4DEA5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_05472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000291">
        <property type="protein sequence ID" value="EFE39815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020433.1">
        <property type="nucleotide sequence ID" value="XM_003020387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEA5"/>
    <dbReference type="GeneID" id="9584175"/>
    <dbReference type="KEGG" id="tve:TRV_05472"/>
    <dbReference type="HOGENOM" id="CLU_061288_22_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="210" mass="24302" checksum="7B6AD176612CD17D" modified="2010-05-18" version="1" fragment="single">ADSLTEEQVSEYKEAFSLFRAFPSPKQMETVTCQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDWSYFYVVTNLPFLLFTVLPYRLTHQWMDAGNNIVFKDLGYSNQLITCVLALLSMFILYSQWDKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEH4</accession>
    <name>D4DEH4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000294">
        <property type="protein sequence ID" value="EFE39752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020370.1">
        <property type="nucleotide sequence ID" value="XM_003020324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEH4"/>
    <dbReference type="GeneID" id="9584109"/>
    <dbReference type="KEGG" id="tve:TRV_05541"/>
    <dbReference type="HOGENOM" id="CLU_023134_0_0_1"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="323" mass="36428" checksum="AFF27D09F44F016A" modified="2010-05-18" version="1">MINVPLVVGTAYVKWQLPSSASADHNGHTEKALLHDHRASWDYEKLTVVRLTVDRNQMLQDCELQLDIFQEFTAENRADRVPLGNIKLNLSEYVDKTESDEGITRRYLMQNSKINATVKVGIAISQIEGDSNFTAPPLKPATVFSGIAGVMSTEHGEINNDGHIPSVNNRGREYSDLQDMYRSTLAAAWATLPDELPPDQLIENIFAGGDGFPQNHSRYKADDEDEVHDNNSLSDAGSHRTIRDSKNSPDHIPRIKDPFTAHSRSDSRHSDFSFGAVGKERNETGAFERSGGKRRKRKTLTEFDYREDLRSWEVSWAKEDSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEJ5</accession>
    <name>D4DEJ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000298">
        <property type="protein sequence ID" value="EFE39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020337.1">
        <property type="nucleotide sequence ID" value="XM_003020291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584079"/>
    <dbReference type="KEGG" id="tve:TRV_05562"/>
    <dbReference type="HOGENOM" id="CLU_241013_0_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="908"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="624"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1656"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="914"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1598"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1611"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1748" mass="193525" checksum="A78CB270F23E10EC" modified="2010-05-18" version="1">MPGPPSKLVSISITPLHCMNMLLIKSLVVRVRPPLQQSDPGFDLIPQRFQRPTVHVTSPTSLAIDAPQGRKLFVFDRVFGESVDQEGIWDYLHDSVNSFMQGYNVSILAYGQSGAGKSYTMGTSGPSEQHDPKAMGIVPRAAQMLFEKLTGSPTHNRSFSGSPVTGLRTPQRYSSASSFGRVSDKPWQMRATYVEIYNEQLRDLLLPESTPPGERNTVTIREDTKGRIILTGLHQVAINSVDDLINALNFGSAIRQTDSTAINAKSSRSHAVFSINLVQRKDGSAGLPLSAQEKRFSMPDPTSSSSSSSASGDHVTIDSKLHFVDLAGSERLKNTGASGERAKEGISINAGLASLGKVISQLSSRQQGAHVSYRDSKLTRLLQDSLGGNAITYMIACVTPPEFHLSETLNTVQYAQRARAIQSKPRIQQITDESDKQAVIERLKAEVAFLRQQIRNADGGERDRRALLTPQERSDRQNERERELQNHLLDVQESYTALSQRHAKLISELTKSDPSADSSNGLDDGGDASMERLKRSHSFAESVEQVVMEYEKTIQSLESSLSQTRASLSATESTLLERETKCAYIETVNGQLQARMQKMLDREANTESYLHDLESKLDSHATGEEKNAAIVAELRKELNRARENEASCEDYISTLEERLAEADQDMELMQSEMDRLEHVIDRQRSLGKLDNLLYELDHVQNGHSRSEYPAEYPTEYSAVGIHDSRKLSSAGSASTIRPKKTTRTRTPSLDVLTEAVETAIPESDDDLLLADGSTPSSIQEETALDLARDDAGLAALERATPTNSTFARDAHDDDDEDAENDEPEPYTPSAAQSQFVAEKLDSVTQELFDLRIQHDHSMNEYALLNAKYQESLRAMAELQDAMDEIRHSQRSQHPVQPAVAFLDTKLAQNGRPRVNGNGVSVSSYSNGGQTSRSLSSELSSAEQANSSSFTSSTTTNNTEVEEADQGEEEDESEESDVVKKLKAEHQQALDAVTSKFNELQMEHEDSLTLLESLKDEVTRYKNAASSPPHTPNVIRRITSQSMMTVDRAHRNLSALRIQAAEEFEGRPETLQSFDQKIDSALRELNSRMERIQALEAENKNVKKEMETKATIISGLTRERSSLQSVSPVDMTVVSQLRDQIVNAEGQMNEMREAHEAKERELAEELKSVNALVESQKAELDSLRKEVEEWQGKHRQTAEELALVQSRLEASEKQVKATVAELEASLANVDAMRGTNSSNKGGVSADEAAATADALEKERSQHQELVDSLKQEIDGHKATIGAHLAKIATLESDRDGSRTALDDLAGSEDQLAPHKARVTELSRDIEVHKSTVEAQQAQLETLQLTHKRELLELESKTKAAAEAQFESQLAEKAAAHEAALDDLRAELTKSKDESAQILKTISSLLKTQSPVTPFTLQDQLQDVLSQKDQFAEKYSALMDTNESLTRQLDEKTETHTALEKQVVDLKNKANEHEMKVNDLAVLVANHEEAIAAKEATIEEIKAEKEKSIRLVEELEEQITSSFDQHNNRLSVIQAEKSMALEEAKAKIAAHDKEIETYRARIEQLEAQTRPISPEGGHIDRGSGSISTNLRKSSSAASLPSPPPAIPLPPLPNIAAAANPASISPPSSRHQSKELANNQFVEDQEARIRTIEKHLHAEKQLTATLEEALGDLEAQSNKVKSDMELWKKKAWQLEEEVTTLRSERNSARLSLQAVEEERSARREAEAARAHLEEKMNAISKKKKKSTLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEM9</accession>
    <name>D4DEM9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_05598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="ACYE01000301">
        <property type="protein sequence ID" value="EFE39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020322.1">
        <property type="nucleotide sequence ID" value="XM_003020276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEM9"/>
    <dbReference type="GeneID" id="9584061"/>
    <dbReference type="KEGG" id="tve:TRV_05598"/>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="505" mass="57665" checksum="FA2E0BBA707A6A21" modified="2010-05-18" version="1">MVHISRVRKDSVAFPPKLLNRVDTLDLEEPQDHDFYSSVYGSRFAAEDLPTDEMPEKEMPKEVAYRMIKDELSLDGNPMLKYVLAVVILFIYRVILADLDHVYSLASFVTTYMEDEAEKLMTESFSKNFIDYEEYPQSADIQNRCVNMIARLFHAPVGEGEHEHDHAMGTSCIGSSEAIMLGTLAMKKRWQNRRKAEGKDCSRPNIIMSSAVQVCWEKAARYFDIEEKFVYCTNERYVLDPEEAVNLIDKNTIGICVILGTTYTGQYEDIKAVNDLLVEKKIDCPIHVDAASGGFVAPFVNPSLEWDFRLEKVVSINVSGHKYGLVYPGVGWIVWRSTEYLPQELVFNINYLGANQASFTLNFSKGASQVIGQYYQMIRLGKRGYRAIMLNLTRTADYLAASLKELGFIIMSDGKGRGLPLVAFRLPPETAEKYDEFAIAHQLRERGWVVPAYTMAPHSEKLKLMRIVVREDFSRSRCDSLVNDFKLALAQLEEMDKKALEKYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEN6</accession>
    <name>D4DEN6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_05605</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000304">
        <property type="protein sequence ID" value="EFE39676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020294.1">
        <property type="nucleotide sequence ID" value="XM_003020248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEN6"/>
    <dbReference type="GeneID" id="9584043"/>
    <dbReference type="KEGG" id="tve:TRV_05605"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="269"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE39676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="501" mass="56055" checksum="0975715C5DC519F4" modified="2010-05-18" version="1" fragment="single">KQKKQTEAEPENNLQQESYARDNNAYIYLLSTYILRLSSRLASMAGVLVDTPLGAPSLPKTTLNDAIPDIDPLEGSTNDDEDGYSILKRYQRHLEYIQLQEEYIKDEQRLAAIMPKSSSEKTYLILTAFFRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNSLVDILPPEADSSIAMLGANEKPDVTYADVGGLDMQKQEIREAVELPLTHLDLYKQIGMLHISGIDPPRGVLLYGPPGTGKTMLVKAVANSTTANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIAGKMSLSPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQSDLEDAYSSQVKGGQDSDKYVFFLLHLFPSQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DER9</accession>
    <name>D4DER9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000308">
        <property type="protein sequence ID" value="EFE39653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020271.1">
        <property type="nucleotide sequence ID" value="XM_003020225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DER9"/>
    <dbReference type="GeneID" id="9584009"/>
    <dbReference type="KEGG" id="tve:TRV_05659"/>
    <dbReference type="HOGENOM" id="CLU_2074851_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="118" mass="13142" checksum="DA08D8A2AFD7B94D" modified="2010-05-18" version="1">MNDIFSVKKEIVSSPEEDINKAQWLTALLANIQKDCQFDNIIPLLLVHKGMSVQAAVDYTVGLIEESYRIVNAAGARLPKLEGKAKEDLDTYIEQCKDQAAGSIYFQYGQPNEYGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF15</accession>
    <name>D4DF15_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_05757</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000323">
        <property type="protein sequence ID" value="EFE39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020170.1">
        <property type="nucleotide sequence ID" value="XM_003020124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF15"/>
    <dbReference type="GeneID" id="9583946"/>
    <dbReference type="KEGG" id="tve:TRV_05757"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="245" mass="27272" checksum="8964CD98DB2AB921" modified="2010-05-18" version="1">MASNRTRRITKEIADIHADRHSQITVDPISEDDLTRLKGSFPGPPGTAYEGGTFKVDITIPTEYPFRPPVMKFDTRVWHPNISSQTGAICLDTLSSAWSPVLTIKSALLSLQSLLSTPEPRDPQDAEVARMLLSDPKEFERVAREWAVMHAGAPRRHTGEGSGGATDESIRRKALKAKEDEQREKLAAYEGYNKDLIDRFCSMGFDVPRVVSAFKYVGIDPMDGDDYELEEAYMGDITARLLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFA6</accession>
    <name>D4DFA6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020079.1">
        <property type="nucleotide sequence ID" value="XM_003020033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFA6"/>
    <dbReference type="GeneID" id="9583843"/>
    <dbReference type="KEGG" id="tve:TRV_05852"/>
    <dbReference type="HOGENOM" id="CLU_1215551_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25047" checksum="C5150B4836CAF5A9" modified="2010-05-18" version="1">MGPVDLPRPSSPARCDAEAEAVGLLSYHGQQKQQKQQQQPSHGRGGLLQAIHGRSPSSLNSLPLRRAEKTGHHLLAAIGCCPTRRAGTRLSRTHRLLRLVGLLAWLFVVVSVAESLLWPPYQTPPEHYAGLRERILGSTQPGRGNPEGQKVFIASNIVQEEMIRGPWGRSLLELVDILGEDNVFVSIYENDSGPGTGDALRELAAQLPCPLFPLRVRSVYLFHLVSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFC5</accession>
    <name>D4DFC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000336">
        <property type="protein sequence ID" value="EFE39474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020098.1">
        <property type="nucleotide sequence ID" value="XM_003020052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFC5"/>
    <dbReference type="GeneID" id="9583862"/>
    <dbReference type="KEGG" id="tve:TRV_05871"/>
    <dbReference type="HOGENOM" id="CLU_037663_1_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="37586" checksum="2E6C26DBDCDF0566" modified="2010-05-18" version="1">MISSEGRFCIIYCIDDLVDVTTYVIDCDTLRCLQLIGPSKLLGNEDDFRNTFLALERYVDQLGPDNHTIIVDENGDLVKFTSEDVTMEIRFPKYTGAMDKHQVIRRSELTEIDRLNKFVDLVEYNSSDSEAKKELAFFKYTLNQNWIWRVWIDLHIHKALQGNEHFVPFHRIIIDDVTENILGFTYKCLSGTRLYDYDGVFNFCWLKQMTDAADELNLRYGVLHNDICPHTFLIDHDKNEVKLYCFGLIIKIGKQTMVPLADVNSLIVWVYQFLTGDRQFLDRLLHQESVSKIEDMGEWKLQRPIEDGFDISDYRKHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFI4</accession>
    <name>D4DFI4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019966.1">
        <property type="nucleotide sequence ID" value="XM_003019920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFI4"/>
    <dbReference type="GeneID" id="9584719"/>
    <dbReference type="KEGG" id="tve:TRV_05934"/>
    <dbReference type="HOGENOM" id="CLU_014627_1_0_1"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055496" description="Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="478"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="921" mass="101143" checksum="935B40D1FEB80151" modified="2010-05-18" version="1">MHIMPSFVLWTFHLCSQWFQGLTDLLPHIPDTEPVNHLVSQTGLLHPGGMKYSKVAPWVCIPLLTCRGVGATNSADGGSDLQLNESPFSKSWQVLGPFEIGTRESSWGADPLEAYGGFQTLQYDPKASFDSSLALNGLANWSIASTHVNSTADPPETILDINLSPDNLTSLQEVYGWDAKQYQAWARGTLTVSKSNSVVALYTDRIWEYRIDNKSYFGGDFFGFRRAPLLLDLSPGTHTVDLRVVRDVRALGAVGEPFINVTLIAQELSKTLIVDEKSILVADVVENRLISPYASVTLHNTIGNPVDVVGIKEDSTQAARFSLKMLNNHVKLEGAQSRAIGFTVEANDKTNVPASVSLYFEYTTPGSSSVQRTQPMTITFTRRKLPEVQQNTFVLPGGVVSYATMRPPTSLECNKNKSAKLPVLLGLHGAGQAASDEIIRTMLDDTWGFADLQHSVRALNDYIKYSGWTGVGVIDSDWVIAGHSNGETGQGTWYTISHYPDKIIAAAPVAGYTSIENYVPYSMWHNTDSLLASTFYRARQDFKHEILVDNFAGIPVYQQHGASDDNVVVYHSRLMHRLLQESGSPSKYHEVPGKNHWYTGIMTSDFLKDFYRTYVQRPNATDLLPQRFSVTLPPAGHMGTRGGIYVDQSHTPDRVGSIEVERSMTNDGVWKLKTRNIRRFHLETSAIRSHVPLYIQIDGSRFTVTPSNSTTTWYTQDAAGKWTSGGDSWRTISQRYGRQAGVNAFLRTEAPFTVTAAAQETRDLALQTCRNLFQYLSADCIISYAVPTADSTTATSLAGNNVTILLGAQPNGYTAGDSAISISARSLDIKTSQGTTSYPFESGLGAIFIRPLVNERLELVIWGSDMAGLQQAARLVPVLTGVGQPDFVVVNKGTPLKGQGSLYAAGFFDSEWKVSAASYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFK8</accession>
    <name>D4DFK8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019990.1">
        <property type="nucleotide sequence ID" value="XM_003019944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584744"/>
    <dbReference type="KEGG" id="tve:TRV_05959"/>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="722"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="913"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1247"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1303" mass="148036" checksum="C28C02B0F48DC96B" modified="2010-05-18" version="1">MGVPKFFRWLSERYPAISQLIAENRIPEFDCLYLDMNGIIHNCTHKDSDSPTFRMTEDKMFIAIFNYIEHLFGKIKPKRLFFMAIDGVAPRAKMNQQRARRFRTALDAELAKEKAIKEGVEMPKEDAFDSNCITPGTEFMAKLTKQLKYFINKKVSEDAEWQGVEVVLSGHEVPGEGEHKIMEYIRQAKAQPEYDPNMRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQSQKKSKELEHQNFYLLHLCIVREYLELEFQELKLDGALQFPFDMERIIDDFILMAFFVGNDFLPNLPNLHINEGALAWMFKVYKDVLPKLGGYVNEHGTINMERLRTLLAALSDVEFRFFEAEYSDARWLKSKTLDGDQTPTLPEKPNVLTITPAQKHIFNRIKKYVTHRPMDEAGQPVPLDLSPSLPARDRKFVEQLADSLHLKWSSVLNQHEERFLRVQLPTNDDDDDEDDDDDESQIAILRVLKKYENAKVKEVTAEDAQMAAEKKYEKKFQDWKDKYYKGKFGWGLENTEEMRKLTENYVQGLQWVLFYYYRGVASWPWFYRYHYAPMISDIHLGLGADVDFKLGQPFFPFQQLMGVLPDRSKKIVPVAFHSLMTSPDSPIIDFYPRDFELDMNGKKMEWEAVVKIPFIEEERLLKAMATKEHLLTPDEKARNTFGVTLKFTYSPDVEFLYPSSLPGIFPDVSRCRCIENVFELPTMEGLDPYVGLVEGVKIGAEALYGFPSLQTLQQTGQLGFHGVCVFQQESRNESMVVTISDPEIGGNTADAKTKLGKRVHVGYPFLQEAKVVCVSDELFDYVQVDGEEHVVPIPHTPTQISQWKKKAEKIESYYSKRLGMVIGDVETIVRVEMLKGLKKTPDGATVKEFTEIPGVETEYAAQLIVDSVMSEDLRFIEREAVPIEEEFPEGARAFFLGEYNYGAPVHVTGHEDGKLSGLLSAVKGKEPEFGREHVLNAEKLSKYTPSFAIARNLRLSPLTLAKITSSFSVNMDGTRVNLGLNLKFEAKKLKVLGYSRRGNSGWEFSERAIGLLQDYMIKFPDFIAGIQRKPQGDLFEPSDFYPADIAKEKIKEIQAWLKSIESKSFERVPLEAEQLDSSIVQAIEKSADELSQSRPTPVAQKIRGVPRNALLKPADAEHRLNNQHFQLGDRVLYAQDSGKVPIASRGTVVGLTRTSRNLLLDVLFDVSFMSGTTLSDRCSPFRGSTVPSSSVLNLTSKQLIALSRATAQNKEQAREQQLPLRAAAPQAMSGMGQLKDEPTPPPLVNSYRGAATGQPSNGVTARRAAAVEEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFN5</accession>
    <name>D4DFN5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_05986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000339">
        <property type="protein sequence ID" value="EFE39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020017.1">
        <property type="nucleotide sequence ID" value="XM_003019971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFN5"/>
    <dbReference type="GeneID" id="9580186"/>
    <dbReference type="KEGG" id="tve:TRV_05986"/>
    <dbReference type="HOGENOM" id="CLU_002511_0_1_1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136926" checksum="CC90A07768931AC8" modified="2010-05-18" version="1">MAPQAPELPTKFPCWCRAVYSWGGESKQDLGFIEGDLIECLNAGDGSWWTGRLRRDRRMVGVFPSNFVKVLEDDFVPATRSISPLPPVTDSPSNAPLYAPKKEKTIFRKPFQGYKQVLGPSAELAKKNAEKETEAPTVPEPLPRGRKSVINRTPRRKSTSRVHPRAVSPAQPARQPTPLPTRNANSQQPERQPTPQPERQPTPQPERQPTPQPERQPTPQLALAPMQPPPMMIPAEPREFEPESSPPPPPPPPHRIAVRRQPSYVQPESSMHDHQYQQENHEFRPASRTPSPYPPSPGTHHRHTPSPLRDAMEDVMSSLQGMSMPHDPHSEPQRTPSPFNPWSPAAFDNLRGPPSQQFAGRPSTSLGLGNSQYSRRGSHFAHKSSESFHDRFQDGPPQLGNYVQRMESRLRQLHNQEEGSDRGNPMLIEDDDNPPPPPPRRGEYNYSPSQQMITRTRGLTYDSGRDTLGRTFTTRSIATNSSSGVQSNTTHSTASTSATNPSLMSGTSAGGFSATSAGSFAKRHQQTSQLRHGMFRSFDGTRSGGFTGFGDDAAGEQRSYTPMTSQSGSYPHLPQDDPRQGATSAVGWTEYNKHEESPGIFGGLTTPKSKKTGFLKKMIESAKTGAATARSSIATAQHIRSLSPTKGLLSGGVGRFSPTKDRDTTADTGLGGNDWVQVRRDVNRATSPSRNELVERAERCQMMDYPVIYAVEELYECAEGDEGLDGLPVTEPTNWAAVNLQLVDKSSRFINSLPPMTSPASLAQGFVCRPHRSDVQRLRAIFTWVAEKIVWDEEIEGEVDVRRVIQMKRGSPREVAVLVMEMCDAVGLHAEVVQGYLKTPGEQLEFDGYTRVNHWWNNVLIDGEWRVMDCSLASPTHPRRALYSSFNPQAAETWYFLARPMEICYTHIPLAPEHQHICPPISPDVLLALPCACPAYFKNGLHMPTYDTSLVRLTDLEMLQVRVLVPPDIECIAEVEAIAFARDADGDVFESGDIITKRALAQPDWIQGQKRFTIKAALPGDEGQGVLKVYAGKKGLMHSIKDIPHALAFALPITHTGDNPPYEFVIRHPTPHAQRHDLYVIQPQCARLTINNTFVFAVRQHPSSLPSSPKAEEPSGRVSPNPFARPSSALSMVSSVATISNASTTSSTVSSNYKHQNSREKPAKLAIQTPSGKILRLSRKADHMITTSSDAESGFDGPPDGSVWETVIKVSERGVWRGLVLADRTARWCVWGEWECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFT0</accession>
    <name>D4DFT0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_06032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019930.1">
        <property type="nucleotide sequence ID" value="XM_003019884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFT0"/>
    <dbReference type="GeneID" id="9584682"/>
    <dbReference type="KEGG" id="tve:TRV_06032"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE39306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="494" mass="55007" checksum="AC824FB0E5729100" modified="2010-05-18" version="1">MSKENVVVDIEAGVRDGDSSDGVILDVAVARPGTAAGLKTAPDGHTILVPQPSDSTDDPLNWSSAKKWIVLLIISFAAFLPDYGSAVGAVTLLPQAEIWHMTPDEVNHSQAGNVFMLGVGGIVTVICSAYFGRLPVLFWFMVGAVATAVWCTAAQSFESFMGGLMFINDIFFFHEHARKINVWSSFIIVSPYLGPLLTAFIINTQIWQWAFGVYSIETGLCFIAIVLFMDETYYDRKLPVDQRPVRVSRWKRLIGTEQWQSRHQRNSFKDAFMRPFIVIAKPAMLISCIVYLLTFAWVVGINTTLAIFLVPVYNFGPKQIGFFYFTPVVAAILGEIVGHWLHDRVASLAASRNQGRFEPEARYLVTWISTPCICAGLILLGFALEREYHYMLASLGWGLYVFGIMITTVATSAYVLDSYPEASGEVAAWLNFSRSTAGFIVSYFMVRWAGDQGPIRQFGAMTGICGFAFVMLLIFQFFGKRIRHWAGPVNFKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFT2</accession>
    <name>D4DFT2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000341">
        <property type="protein sequence ID" value="EFE39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019932.1">
        <property type="nucleotide sequence ID" value="XM_003019886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFT2"/>
    <dbReference type="GeneID" id="9584684"/>
    <dbReference type="KEGG" id="tve:TRV_06034"/>
    <dbReference type="HOGENOM" id="CLU_018398_0_0_1"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41595" checksum="EB725FA7DFB4EB93" modified="2010-05-18" version="1">MPRIPYSLFLRAHRIDPLLPPLLRECRDLCSARNELRWLTEYARSRDTGRESWRWKQRLQLLVRQRAAGKPLQYILGDQPFGDLTILCREGVLIPRPDTESYTTRIAQRLLTENRLNPTRSIRIIDICTGTGCIPLLLHSLLAPSIPTISIIGVDISATALSLAKKNLEYNIGNGTLLSRARDEIHFVHADILDPCYLESDGSELGEMLSRSNQGGHSKGLDLLISNPPYISPRDFTNGTTRRSVRLYEPTLALVPPAIQHPGIASDSARADSFYPHLLAASAKLEARFTVLECGDLAQARRVAAMADDTRQNSSWSSQRNVKTEIWRCDWDAHLHETTEHVSFDDQEESATLDVTAKPDQGARAVVLSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG12</accession>
    <name>D4DG12_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_06114</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019826.1">
        <property type="nucleotide sequence ID" value="XM_003019780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG12"/>
    <dbReference type="GeneID" id="9584577"/>
    <dbReference type="KEGG" id="tve:TRV_06114"/>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000002">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="21">
        <location>
            <begin position="270"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE39202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="675" mass="75880" checksum="1B78326779E34EFC" modified="2010-05-18" version="1">MWTKSKDNSYKNISIFKEIGQYVFVKPRGLDGSNTSLRALMPDLKELRSLIKPSNTDNGDAISSIILAIDMITKYCKKLKYKRKIVLVTNGKGPMDLDGMDTIAGKIREEGIELVILGVDFDDLDFGVKEEDKDAVKAENESSLQKLCDVCDGVYGTLEQAISELDTPRVKVVRGIPSFKGDFKLGDPDKYDSALTIQVERYFRTYAARPPPASSFVLSGAPPEVQETGDSSANLKDARTDTGKSISNELTSVRNARSYQVTDSGVVGGKRDVERDALAKGYEYGRTAVHITDSDENITKLETKAALEIVGFIPIENVCFIIKSILIIYKLPFTDYVLIRTNNKAIIALSSIINALHEVESYAVGRLVTKDGKSPTLVLLAPSIDPDYECLLEVQLPFAEDVRCYRFPPLDRVTTMSGKVVKEHRNLPNENLLAAMEKYVENMELVQPGEEGVDQAIRWRAIHPTKPLPPIPKVLQKQSRQPDELMEQSKSALEQLIKASDVKKVPPKVKGRKRNRITDKPLSGLDVDALLQGEKRQRISPENAIPEFKQALANTDDINTVKKSVKQMCAIIENQIKHSLGDANYDRVVEYIGTMRDELISFEEPDLYNDFIRELKRKLLDDKLGEDRRELWWLIRKKRIGLIDDKLVEISKVTEQEAKEVCIYPIPTRIFAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG27</accession>
    <name>D4DG27_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_06129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019841.1">
        <property type="nucleotide sequence ID" value="XM_003019795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG27"/>
    <dbReference type="GeneID" id="9584592"/>
    <dbReference type="KEGG" id="tve:TRV_06129"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="433" mass="46111" checksum="AFD0416C69D6688C" modified="2010-05-18" version="1">MPIIEQNTNTCHRPDQTACVKKGGDTTPPSVVDDNLEAGNNNEAKGGFKAWIYVLASFFLFMNACLLSTSSPSSISSIGSFQVFLVIVLGVFTGPLFDAGYLRQMLTLGCTLVVLGMSTLSLATAYWQVFLAQGLCVGLGSGLLYVPALAFVSTLFPDSVRPWAIGCVNAGGGMGGIVYTFMLRDLEPQIGFGWAVRAIALVTLVLSVVALAILLPYRSKAPKPQHRRAMFDLKALREPSFLLFSIAMFLNYIAFYITPFYIPMYATEALHQSRSFAFAYLVYMSITSIIGRTLPMLAAGRFGSLQVYIAATVGTTVALFCWTAVHNVAGFLGFTLMYGIVSGVQVAAPSAAISHPVLSPTMNVIGTRMGMGWMFAGVGVLVGSPIAGALVNVTPGRVDFKPAQCFAGAVAAGALLCLIFPLIAVIKHDKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGJ8</accession>
    <name>D4DGJ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000359">
        <property type="protein sequence ID" value="EFE39028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019673.1">
        <property type="nucleotide sequence ID" value="XM_003019627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGJ8"/>
    <dbReference type="GeneID" id="9583561"/>
    <dbReference type="KEGG" id="tve:TRV_06302"/>
    <dbReference type="HOGENOM" id="CLU_060131_3_1_1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="251" mass="28690" checksum="7CC476E5F3344DC3" modified="2010-05-18" version="1">MPIRLARYSDLEAISSTLAEGFHEEEVMGPLLHPLRREYPNDYLNYWRRKCWEKWWNYSYVFVVSYIEQDEEAEEADEASLDDRKDDRSAEEPSRPPRETITGVAQWHRMGPGWESVWKPLGKWDPTPNRAASRPPQLTEESVRQALIKALGALYASPPHRLTNWSLNCLAVRPKYQRLGHGRELVAWGVDRAREEGIAASVLAAKGKDTFYRRCGFTELAGWATDGEGNPLKGVVEGGAVMFTRVKEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGQ1</accession>
    <name>D4DGQ1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-dimethylallyltryptophan N-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.261</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019638.1">
        <property type="nucleotide sequence ID" value="XM_003019592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGQ1"/>
    <dbReference type="GeneID" id="9583538"/>
    <dbReference type="KEGG" id="tve:TRV_06356"/>
    <dbReference type="HOGENOM" id="CLU_049766_0_1_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="37267" checksum="E385E3E5FE8881FA" modified="2010-05-18" version="1">MCEAGTVIDIGGGRLESSLKELTEYQFLGSNGGNPRDLPTGLFYNTRGLKIWKDITHLPEYQQTQDEINLLNSFKDQIADWIVEGCTIVDMGSGDTRKVLPLLAHLEQLKVEVQYFALDLSKQALEQTMEQLVPEFHYVRCFGLWGDFSDGLNWLRPVKSPKLILSLGSMFGNDEFSLAVSRLEEWKHVMGRNDLMLLGLDACDYLPELWESYHDPQRVWDSFIRNGLKYSNEVLRCDWYKEEDWQISGRIDSSPDTVHRFSIIARRDVHCHPLGLHFSAGERVDFFEAWKYGPERMRSQFKMAGFAEVERWQAPGNRPFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGQ7</accession>
    <name>D4DGQ7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000361">
        <property type="protein sequence ID" value="EFE38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019644.1">
        <property type="nucleotide sequence ID" value="XM_003019598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGQ7"/>
    <dbReference type="GeneID" id="9583544"/>
    <dbReference type="KEGG" id="tve:TRV_06362"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_1_1"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="344" mass="37739" checksum="D0E9AAE1DA1BDCF7" modified="2010-05-18" version="1">MEFPAGGVIVIVINTIFTSLAIIAVILRFYAIQVIGRNYYMSDYLIVLGLIFTVATAVLAMVDGGAGLHMNQATDRQLLMLLKTFVAGPIIWSTATTFIKLSILSFYHKVFGSKQSMRIAVYIESTVTIALYLAGILEPFLLCRPFNYTWNKDAHGTCGNATKAYLAIAVANLIVDLSIYLLPIPVLWNLQMNLVKRLALCGIFAIGLVLRIYAVLTLKVNDYSHSMIKDVTFGGLEVELGAINACLPFYRPLVAKYIPSLKFDRNSSRGSYGSAKSRPGHVPCSSEGGSRDSRGSQNPLNPPSCNPYVDEVVGDPYANGDRHIQLDDSSLEKGITQEQRPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGS4</accession>
    <name>D4DGS4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000363">
        <property type="protein sequence ID" value="EFE38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019583.1">
        <property type="nucleotide sequence ID" value="XM_003019537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGS4"/>
    <dbReference type="GeneID" id="9578357"/>
    <dbReference type="KEGG" id="tve:TRV_06379"/>
    <dbReference type="HOGENOM" id="CLU_078820_0_0_1"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="263" mass="29817" checksum="CDB746DCE0762CF0" modified="2010-05-18" version="1">MSGFSVGNFSDYRYSHTISNKQTVLVSRMLSPLHKVLNKPGKPATLTSVNDLDEYLSLSFSFDSTQLASPKRRTLDDLGTETWNECVKELAKPQNIDRIETMKILGKFVNTAHLVMFLAFLLIEWGMDEESDSSGMGYSDLAKKVLERLDRHNSGISKEESSEARELAAECSFQLSILTWKDRLKGLGIAQQPIPFAVHSLEWKTKAADILFRIGTAKKREGDPTAIEWLQCCHDFIFAQSEEQETYEQFESIRQALLHELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGU5</accession>
    <name>D4DGU5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019526.1">
        <property type="nucleotide sequence ID" value="XM_003019480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGU5"/>
    <dbReference type="GeneID" id="9578347"/>
    <dbReference type="KEGG" id="tve:TRV_06400"/>
    <dbReference type="HOGENOM" id="CLU_427721_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="734" mass="73541" checksum="3BAC5B62FE33C4BE" modified="2010-05-18" version="1" fragment="single">PTGTGTVIPIPTQPTSPTGTETPIPTGTPIPTSTGTVNPTGTDTTTCEPTETPIPTQPTGTGTETPIPTQPTGTETPIPTQPTGTGTETPIPTQPTGTGTETPIPTQPTGTETPIPTQPTGTGTEIPIPTLPTPTGTEIPAPKLPPPVPTQPTGTGTETPVPTQPTGTGTGIPIPTQPTGTGTETPVPTQPTGTGTETPVPTQPTGTGTETPIPTQPTGTGTDIPVPTLPPPVPTQPTGTGTETPVPTQPTGTETGIPIPTQPTGTGTEIPAPTQPTGTGTETPVPTQPTGTGTEIPIPTLPTPIPTEPTGTGIPIPTQPTGTGTEIPIPTLPTPIPTEPTGTGIPIPTQPTGTETPAPTQPTGTGIPVPPQPTGTGTETTIPTEPTGTEIPIPTQPTGTETPIPTEPTGTEIPIPTQPTGTETPIPTEPTGTEIPIPTQPTGTETPIPTQPTPTGTGTPIPTLPTPIPTEPTGTETPVPTQPTGTETPIPTEPTGTETPVPTYPTYPTGTETPVPTSTITLTTTETYTSTSCPGKLKYLHKRSVNLVADALTYVLVTTETHTSGTETFTSTRTETSTLTYTHTTTTETVVPIPPSPTGTGVPQPPQSPPPQSPPYPTGTGVPPSPPGSTGVPPPVPPPSSSETPVPSQPTGTVPQPSQSQPPPYPSPPPSSTETGIPSAPPSETTTGGTNPTQQPSPTSPTPVIPPVYTGMATRTKGSGVSILMVIGAAMMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH87</accession>
    <name>D4DH87_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_06542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000374">
        <property type="protein sequence ID" value="EFE38783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019428.1">
        <property type="nucleotide sequence ID" value="XM_003019382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH87"/>
    <dbReference type="GeneID" id="9577876"/>
    <dbReference type="KEGG" id="tve:TRV_06542"/>
    <dbReference type="HOGENOM" id="CLU_070647_2_0_1"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055860" evidence="9">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE38783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="234" mass="23701" checksum="0FFFE70E24ECFDBA" modified="2010-05-18" version="1">MKLLAILPALLPLVAAHFNVEAPPTRGGSEDTQPMFPCGGPTEPSRERVKIPLDDPKLAIAMEMGHDQAAVQVLLGLGSNPGSNFNISVVKTFRQVGLGAFCLPEVSFSEDVVGFKPKDGMEATIQVLSNGDPKGGLFHCIDAVYTMSARYVKPESCKNGTGVEAMPFSGEAANRNANESTPNGQPQGGSSGGSGGSGGSGGQSPSPTGNAAPLQTAAVWGVLGAAVAGGVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHT1</accession>
    <name>D4DHT1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_06738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019249.1">
        <property type="nucleotide sequence ID" value="XM_003019203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHT1"/>
    <dbReference type="GeneID" id="9577489"/>
    <dbReference type="KEGG" id="tve:TRV_06738"/>
    <dbReference type="HOGENOM" id="CLU_096859_0_0_1"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="167" mass="17259" checksum="4B52DC8EF1047AF8" modified="2010-05-18" version="1">MVYLATSQDYLKQSSLLLEAYPDTTRITTKYSYPKRPSAKERAKAKSKTAAPAPTETPEPTTVPATLTLKTFNPATGICLKYQTNKAAEVGRLIAGLGKLASGSPIEDFVPAPVPVKPAAGEVEDVDMPDATPSSAVDEISGSNTPVAGGGGGGKPAKGKKKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHY0</accession>
    <name>D4DHY0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_06787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000389">
        <property type="protein sequence ID" value="EFE38536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019181.1">
        <property type="nucleotide sequence ID" value="XM_003019135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHY0"/>
    <dbReference type="GeneID" id="9577184"/>
    <dbReference type="KEGG" id="tve:TRV_06787"/>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="14">
        <location>
            <begin position="79"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE38536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="460" mass="50567" checksum="0016931AD77C0047" modified="2010-05-18" version="1">MVMAPSASDLPRLYFNDHEHEKLKHVECPDDETRGISHLAEARAASRQLVFEILKQKAAAVDVKTCYPGEEDPFYVADLGEVYRQHIRWKTNLPRVKPFYAVKCNPNPQVLRLMAVLGNGFDCASKAEIDLALAAGVDPSRIIYAHPCKTKSYLRYASQVGVKQMTFDNTDELYKIKEMCPDAELYLRILTDDSASLCRLSMKFGASLSSARPLLELAHGLGLNVVGVSFHVGSGAEDPKSFIKAVQDARFVFDRAAEIGFDLKVLDVGGGFSDDTFEPFAAALGDALDTYFPPHIRVIAEPGRYYVATAFTLAANVIARRDVGVEEPLSDSESDSTTPSRASTPSSSGAYMIYLNDGVYGNFSNIVFDHQHPVAQILTKDDDYTSAPIEYSIWGPTCDGIDVISERVTLNGLLGVGNWLYFENMGAYTQCSATRFNGFTDKHEVIYIVTEPGAAALLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIE1</accession>
    <name>D4DIE1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000406">
        <property type="protein sequence ID" value="EFE38293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018938.1">
        <property type="nucleotide sequence ID" value="XM_003018892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIE1"/>
    <dbReference type="GeneID" id="9582108"/>
    <dbReference type="KEGG" id="tve:TRV_06949"/>
    <dbReference type="HOGENOM" id="CLU_078879_0_0_1"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055887" evidence="3">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="290" mass="30476" checksum="59994D8544674276" modified="2010-05-18" version="1">MRRILASLTLLPAVLAADIKVEMLYQRIMAVTMTTTKSAPPTECTYTPPPRNCERACGVGNVPCVNETRCYNPYIGEVCCMDGKYTLKQCGGHEVRNYDPPPGEDSSTTRRLSSTSTSEPITSSSTNSAVTSSGSAQPSNPSGSNDKDGNGASKKVSAIIGGVVGALAIIGAVVVGVVWLILRSRAKEKAACAAAAEEGADNGMEFKAQVPYGSGEPRQTASRSVMGYYAPSTLGPTEATSSIPFYNMSTPRRVTELDAEGIYHINPTSSSVTDDVISPSSEGQLSKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIU5</accession>
    <name>D4DIU5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_07106</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018880.1">
        <property type="nucleotide sequence ID" value="XM_003018834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580052"/>
    <dbReference type="KEGG" id="tve:TRV_07106"/>
    <dbReference type="HOGENOM" id="CLU_238425_0_0_1"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="2"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="438"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="603"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="839"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="127"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE38235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1787" mass="196458" checksum="7A67682D1A61F47D" modified="2010-05-18" version="1">MSVQVIARIRPLLKTERECDVIVQPCSSSSSAALQSGSEALSKTKENDKPLKAKKVKNGKGEDADISLAKATVVRIPNPRNEGEDFSFKFHSVYDGTATQQDIFDAEVAPTLKHLFNGFDVTLFAYGVTGTGKTHTMRGGKSLADRGVIPRLLSGIYRRCRKLERDTEGRTKVEVAMSYYEIYNDKIFDLFEPVEKRTPAGLPLRDNGVKTVVVGLTERPCTSLKEFEVIYDQANMNRSTSATKLNAHSSRSHAVLSVKLTVTTEHQARISTASCIDLAGSEDNRRTENGKERMVESASINRSLFVLAQCVEAINKKQARVPYRESKMTRILGLGQNNGLTIMILNLAPVRSFHLDTLSSLNFANRTKKIESREIENEPMFKGPPRPAAGRVTGTGVKRQPLRPLAASINANIAAVTAEARKPSDGKPAKAFAVYTDISHSKSSTKPGASEAAQRKSPLKRRSGNGHQPGPRPSKMARTEERLQHGMSSMSAAKFEELVEKKVREVLSARQSDDFETESKELNKQVQRRLELLEQRIDETEDSRADGLSYLLMAKQHQARGEYSSALRMYELAQPFFPKNAKLALKIEALRCEKAAGKKITVEFQEQSENPGENGEEPCEGDYDEASTTDAPHRRPRQIRTKASPLSPETLPSNAEGKEEGGLSPRSSHILSVINTRDIEQIKLLRGVGVKKAECIVDRLCDMDGGAEGHIQLHSLADLEKMKGPVTYSLFLVHHRHHHCLIDFWPAVVSSINFGAVAGGRRALRCDWLAAEGHRDPKEKHPNFDARRAKAASRLATNFALAAQLVQGTNGSLTLVNSVLLSRGYTVPDVRSVKEKQYAATGNYPPPGQEGYGQQQPDTQHPQRPPAHTVLGAPGAPNAPPHDSAPAPAHSHGRKKRAYANQAFDFGVGANAALNQPGVGAEGYGYPGAQQPQGYPQGAVYPGQQQAPVPAAPYPGADAGYQPPAPSYPPQPGPGMAQITQQMGQMSMGDQQQPQPGMQRPVQLNQLYPTDLLTHPFNVAELDYPPPPIVLPPNTSVTPSVYANCPAQYVRSTLNAVPTTNSLLKKSRLPFALVIQPYASLHDSEDEIPVVSDQVISRCRRCRSYINPFVTFLDHGHRWRCNMCSLTNDVPQAFDWDAAAQKALDRWQRPDLNHSVVEFVAPQEYMVRPPQPLVYLFLIDVSYASVTSGLLATAARCIRESLDRIPNADRRTRIGFIAVDSSLYYFTIPRDGSESSEPNMLVVSDLDEPFMPIPGDLLITLAESRENIESFLDKLQEMFQNTQNPGSAMGSALRAGHQLIGPVGGKLTVLTASLPNMGFGSLEMREDKKVLGTSKESSLLQTGNSFYKSFAVECSKQQISVDMFLFSSQYQDVASLSNLPRYTGGQTYFYPGWNAARSEDAIKFAKEFSDYLSSEIGLEAVLRVRATTGLRMNTFYGNFFNRSSDLCAFPAFPRDQAYVVEVAIDETVTKPVVCLQTAVLHTTCNGERRIRVLTLALPTTQNLADVYASADQCAIATYFSHKAVERTLGGGLDAARDALQAKIIELLSTYRKELAGGSVGGGGLQFPANLRGLPILFLAMMKNLGLRKSAQIPTDMRSAALCLLSTLPLPLLIQYIYPKMYSLHDMPDDAGIPHPETGKIVLPPLTNLSSERLVPHGMYLIDDGQTQFLWIGRDAVPQLINDVFGLSDKSLLRVGKQVLPETENDFNERVRAVISKSRDKLSRGVGSIISPHLYVVKEDGEPGLRLWAQSMMVEDRADQSVSLQQWMGLLREKVSLPPSSLSIWPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ43</accession>
    <name>D4DJ43_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor SipA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000422">
        <property type="protein sequence ID" value="EFE38128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018773.1">
        <property type="nucleotide sequence ID" value="XM_003018727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9581169"/>
    <dbReference type="KEGG" id="tve:TRV_07208"/>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000079">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000349">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055918" description="Transcription factor SipA3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="425"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1510" mass="169448" checksum="42F741B8FC9B3107" modified="2010-05-18" version="1">MRLSSSARLGLLLLSEVFNFYFLYPCGGPNAHAVLTNDVVSLKAHRFADSSNLTYSSLIDVDMFEQPEKVKPRRVVAKTWQQVFLIYYISFTFILPPLADPKCSTVEMASQIQLSIPQEGKLVNVVPVVLKEAALDSPSFRATTVHFSEQIDYMERWLDNYIKTTGRLTSELASLENISNGILAHITSPPNISEAILDQDYALLAMKRYGECFRDSWSGMINATKRFEVQVAEPIRAFMQGDIRAFKIYCYSPLTPAQELRRVLDQTQKQFDQLQARYSSQGKSKEPSSLREDAFQLHEARKAYLKASMDFSVQAPQLKVALEKLLVKVFFDQWREFRVVRDASSATFTKYGQEMERTKGWTHELEAGEKSARRDLLIARKQIEESVEYSTRPSRELDDYSISTVPYLGSHGPASVKLAESHVFLPEKQGWLNLRVLTGKPTRTLWVRRWAFLKNGIFGCLVQNPRTGGVEESERIGVLLCSIRPAFQEERRFCFEVKTKSNTILLQGETQKELTDWIGSFEAAKRKALESPSSEMSAASKSKSPDPAFAISQPPAPEFAADPSDSLTPNTTGELPAVERGVTTPLLDLDALGVRSSADFSHSRRSTGPDRDADGAGRDHTSRIIQKLDIHRKQNPNSPLLVPPSPAQPSSGIASLISASHSMFPVTSVPFAKDGNVDSGKPRGASKGDRSHTSLAPSTLVNPPAPTSMSRVAIMVSAERGIGMGPGDTASSIPTGMMANLWGSSQWAMVNQLQRDEPTGAPASTSNHPVVEITPDTPSSSTGNPQGRTSMTRHRATVSLGDTGAFHPDTVTALHDYPSYYPQQLRPHNSQFRLLFPHIPRNESLVLVFRATFSPNDQQDFPGRAFATTHNIYFYSNHLGLVLTTCANLRSITEVTAAPGRDCDFLYLHVVPEKGSDIPGRLGVKTFLEPLKLLQRRLNYLVTNAALDNPAGLETVINTLIKLETTGPTRTPSMDSWEDVSLNTPADDGTMVPKPEKLLKASTYIDHDLDIDPTKQNSATQASRIRLPSQPVIYEPQGSLNLAAEQYVNMSPKALFLVLFGDNSPIWQLSQHQRRAQTNGMKISSKGPGSLYLPPIFDVRWRIKFAWLIHSVRFSKNSQFSHSTNIVYHLGRSHLADVCDYQIIDVFNDHLCYVVTDKRTPWHLPFKRQFRLVSKAVITHVSKSKCKLAIFTKVEWISQPYLISNLIDLVSDQVKRLGPYPTTKSAISMFGNIGHQTETSNITVSERVRLQLQRPLKQSGLLPLLLETSGSLFQSAASSLIIWFWALLRWIWKVSNANKTILLPLILSLLANGFHSWRDTMDWWQERNAGKFMARLGVRPNVVMGKAVYLKDLNDAVPDSVGIQGFNTSICFSTFREENGLTRDNLLLPPSGTPAQNKISRNAAYRLQRTRERLGSYRHNLLVGLKVVNSIEKEVLHLEWERWLRRETGRCAMLDIMLKEHIQYHDNDDYDGVLGIRKQILSGNQKEIEKWYKEYCSSCQRDQERIHINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ92</accession>
    <name>D4DJ92_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000428">
        <property type="protein sequence ID" value="EFE38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018713.1">
        <property type="nucleotide sequence ID" value="XM_003018667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ92"/>
    <dbReference type="GeneID" id="9581034"/>
    <dbReference type="KEGG" id="tve:TRV_07258"/>
    <dbReference type="HOGENOM" id="CLU_510171_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="534" mass="61189" checksum="A05E843348A2AAE3" modified="2010-05-18" version="1">MVEDGADEDEDREGEEKANRLLEQKQATQARLHRQGHGLQHNPCKDLIEASNKKTRRRKTESKQREERNKEEEEIAGEKKKKKKKREWKKQASKQGEVQVSLNWWRIALLALLLGASFASFFSFSVSRLVVSLLLSCLSVYLSLLVFDAGVDAAASVYQLLVRGLKEFPCLSLLLLLLLFCFFLSGAFFFLFFAFSSLFFASSTAYHSFDTLGIRPSVRGMLLFGRDETTIMMIDDDDDDDDDDDDDDDDDDDEMMMKQDYKDGRDKCMLYCYSYIQPVVDSQPGVEYSRFPVMHIHQCSLSFSNDQSRWLPRRSRRALFCFFFFFCFVYQKQKTSKQTSRGNCTMDTRLDFVPGPVLHSTPPPPLLRPWFLQKRRRPLTGPRWLSFSPPSHSFSLRSAKIASSSNLQEVRGAWSKQARGWIKDNSQLTLHGLVILFAGKHLMGLVAFSFCCFLCLLLRLLPRRGGDALAEGWRPPPLSPLQTPFSCSQSLSLRYAAPFFWKQASSSLDSFALRALLLLLPLLLLLLLLLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJJ2</accession>
    <name>D4DJJ2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000437">
        <property type="protein sequence ID" value="EFE38025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018670.1">
        <property type="nucleotide sequence ID" value="XM_003018624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJJ2"/>
    <dbReference type="GeneID" id="9580823"/>
    <dbReference type="KEGG" id="tve:TRV_07360"/>
    <dbReference type="HOGENOM" id="CLU_197955_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="78" mass="9875" checksum="6A4A11C5BE9B24E0" modified="2010-05-18" version="1" fragment="single">TRRRKDENETRAIRLHAEHSEREREREREIEKREIEEKEKEKEKKEKKNKKDKKDKKRTRDEMMTNKDRPSQKRERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJS8</accession>
    <name>D4DJS8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000444">
        <property type="protein sequence ID" value="EFE37900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018545.1">
        <property type="nucleotide sequence ID" value="XM_003018499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJS8"/>
    <dbReference type="GeneID" id="9584474"/>
    <dbReference type="KEGG" id="tve:TRV_07446"/>
    <dbReference type="HOGENOM" id="CLU_031559_3_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="39583" checksum="17D3C867ACF1ED6F" modified="2010-05-18" version="1">MPVHRPRQAQRINQLFILVSITTVFTLYFLFFREPPSRTHGLSSSQQQQPQRPGSGKLATASRELVVASVKADDTAWIQEQLAGWKANIYVADGDAASNSGLSVPVNKGREAMVYLTSIRLAARLYDIHAWTAVPMAQRRPNIRYVQTMDRLGGQVVQMALNDYTSSTPADGASVISKLQLQAVVKTGYAPLRCTWIPGCPVELHPLKPVDEGPIVRQQTELAFAAVFKTLFPGTEVPAEVGATCSSQFAATREQVMLRPKADYERIRKWLVETNLPDDISGRIMEYMWHMIMQKKPVYCPPAGECYCFTFGLCNLECTAAKCEKQYVLPTYAAVPDGWPEKGGGENGWPKPGWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK10</accession>
    <name>D4DK10_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000449">
        <property type="protein sequence ID" value="EFE37807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018452.1">
        <property type="nucleotide sequence ID" value="XM_003018406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK10"/>
    <dbReference type="GeneID" id="9584386"/>
    <dbReference type="KEGG" id="tve:TRV_07530"/>
    <dbReference type="HOGENOM" id="CLU_2747206_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="71" mass="7946" checksum="7AA1F69216DF9883" modified="2010-05-18" version="1" fragment="single">MASIQSPTPKLDRYIIIHVATTCDEHGVYVTKDSAEVIELGWILLDTKNCEEIHRESVLVKPVNTPITPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKD3</accession>
    <name>D4DKD3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000466">
        <property type="protein sequence ID" value="EFE37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018337.1">
        <property type="nucleotide sequence ID" value="XM_003018291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKD3"/>
    <dbReference type="GeneID" id="9580032"/>
    <dbReference type="KEGG" id="tve:TRV_07655"/>
    <dbReference type="HOGENOM" id="CLU_089018_0_0_1"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25997" checksum="96164FA405F30E3F" modified="2010-05-18" version="1">MLFPSFFLTLTPRHSIKTPLSLNLKSLEPFSLAFAYLPFKMRTSILFSIAASLLGASAQAVEAPIKGYGVEPFSWEVKATANGPPLTLNGTVEEVHSQLLKINPNYDIEMATSGRKREHARDIHGLFKRDNVICGRQRECSRKRIEEGIAYLYRVPGRPTNGPGPGNCGRVSCSYDSAIWWCNDNTFTKVLPGFYNVAEGAQLILNTCNPGGSYVSGQDFHDDKWNVIVQYTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL22</accession>
    <name>D4DL22_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000490">
        <property type="protein sequence ID" value="EFE37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018093.1">
        <property type="nucleotide sequence ID" value="XM_003018047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL22"/>
    <dbReference type="GeneID" id="9579305"/>
    <dbReference type="KEGG" id="tve:TRV_07896"/>
    <dbReference type="HOGENOM" id="CLU_053907_1_0_1"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE37448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="276" mass="30878" checksum="7B41F71FBC855571" modified="2010-05-18" version="1">MAKGQKTSPYFKRKRPDIASCIPFPPTSAVLFGLIQEKLAHEPFRLLIATIFLNRTRGEVAMPVICSVFEHYPTIEALANANFDELVLLIQRLGLQNSRARKCIALAKAWIENAPECGKRYRKLHYPNKSDGLDIGCGEAVTDDDPRVAWEVGHLPGIGPYAIDSWRIFCRDRLRGLATDWNGADALEGFSPEWKSVLPKDKELCAYLAWMWLKDGWIWDPQTGTKVAASRRVLRAVENGGLVLQKSSGKWILDLTLVKETSLSIDVGLGKFVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLH3</accession>
    <name>D4DLH3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_08047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000505">
        <property type="protein sequence ID" value="EFE37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017954.1">
        <property type="nucleotide sequence ID" value="XM_003017908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLH3"/>
    <dbReference type="GeneID" id="9579832"/>
    <dbReference type="KEGG" id="tve:TRV_08047"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="469" mass="51161" checksum="01C81D6DE7E5432E" modified="2010-05-18" version="1">MASETLTTISPITGKPVVTRAGVTQDELAALPKTAQEAFRAFSKSTTLAQRQEIVARALNLMAKKKDVLAREVTEQMGRPIAYTGVEITTAIKRGEYLNRVAGEALGEPVPGDAEPGFKRYLKKEPLGVVLIIFAWNYPYLILVNSLIPAILAGNAVILKPSPQTPTVVEQVSSIFLEAGLPRNVLQYFHCGSLVNLEAIIRSPLINHICFTGSVAGGLAVQKAAADRIVNVGLELGGNDAAYVRQDVDLAWVAEEIVDGAIFNSGQSCCSIERVYVHEKVHDAFIQEIKKVLSNYRVGDPFDEKTQIGPVISQKARENILSHIEDAIKGGARDETPANSTFDNLPPVGNFVKPTLLTGVTHSMRVMAEETFGPVIPVMKVKDDSEAIRWMNDSDLGLTASVWTKDVATGEKLIQDIEAGTVFINRADYPSPDLAWTGWKNSGRGVTLSKFGFDQFIKLKSFHLKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLM0</accession>
    <name>D4DLM0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_08094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000513">
        <property type="protein sequence ID" value="EFE37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017894.1">
        <property type="nucleotide sequence ID" value="XM_003017848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLM0"/>
    <dbReference type="GeneID" id="9583793"/>
    <dbReference type="KEGG" id="tve:TRV_08094"/>
    <dbReference type="HOGENOM" id="CLU_1929121_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="131" mass="15259" checksum="10B94530978378D7" modified="2010-05-18" version="1">MYPVRDGEVLEAVGLDFWTKDPTCIWIVNQEEAQKRKRDGKKEKKENKEDKRSDHQIFNRSKHKGTDHVPKSTKVLDTSIHPIGLFFFLYLTNCCMHLPFSGRTSWTLDNQDSKDQPNPDREKPKTLSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYW6</accession>
    <name>D4CYW6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000001">
        <property type="protein sequence ID" value="EFE45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025800.1">
        <property type="nucleotide sequence ID" value="XM_003025754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYW6"/>
    <dbReference type="GeneID" id="9582043"/>
    <dbReference type="KEGG" id="tve:TRV_00003"/>
    <dbReference type="HOGENOM" id="CLU_037132_0_1_1"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="444" mass="47594" checksum="0C49B80B5462A70F" modified="2010-05-18" version="1">MGKKKRGHPDLEELLARPWCYYCERDFDDLKILISHQKAKHFKCERCGRRLNTAGESLSQVDNALQNRSSLDIEIFGMEGVPEDVLQAHNQRVLQQYQQAEAERRAATGNPAPGTSGSSGQSKKPKFESPSELKKRLAEHKARLAEQAAGGSSGDTTPVGAGQQSQSTPGGTPYQQPSTPQYNAPQQPANGSGQHYAAPYGQAPAAFPQQPQQPGFVPPAGPQSYPMHQYPPSTNMPTSPYPQAGVPPIVSPVGASPTLPYHHQQHHQAMRTHTPPQTISPSYPTRTPSLPPAPGLPQRPSFGAPQVNAFQMQQLHQGQVSGPPAVPMPTDAQGNRAHPLPDANFESLSASADKLISEAAKQAKELPAKPSPAPGTPEEGAAGKSSKKEKAKSIRLVYSDNEISPEEKLARLPRYAFVPQHENSSGETAAEPVAGAEEVVNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYZ4</accession>
    <name>D4CYZ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025769.1">
        <property type="nucleotide sequence ID" value="XM_003025723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYZ4"/>
    <dbReference type="GeneID" id="9582012"/>
    <dbReference type="KEGG" id="tve:TRV_00031"/>
    <dbReference type="HOGENOM" id="CLU_2724033_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="72" mass="7248" checksum="84D0BD408026AB18" modified="2010-05-18" version="1">MAESERGKKSSRTEQPGASLSAAGSKGEGEGRAGGREGENQDGDAVLSTKQPAAAAASFRSTSQPASQLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYZ6</accession>
    <name>D4CYZ6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025771.1">
        <property type="nucleotide sequence ID" value="XM_003025725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYZ6"/>
    <dbReference type="GeneID" id="9582014"/>
    <dbReference type="KEGG" id="tve:TRV_00033"/>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="168" mass="18487" checksum="CD7CC12C8DBFAD1E" modified="2010-05-18" version="1">MKKRKRSSKNKTLTQEEIWDDSALLESWEEAAEEYRLYHSIQARGQKVEDVLREAAAAEGSNANEDEMQIETNAETENLSEKSTVNALETVVVEESDGKIKQVDACTTSQVEDEAAPELTAEADQADTAAPASANLASMPQEVLNGAPNPPNSEYIDNRSNHEHVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ01</accession>
    <name>D4CZ01_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025776.1">
        <property type="nucleotide sequence ID" value="XM_003025730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ01"/>
    <dbReference type="GeneID" id="9582019"/>
    <dbReference type="KEGG" id="tve:TRV_00038"/>
    <dbReference type="HOGENOM" id="CLU_044758_0_0_1"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="391" mass="43202" checksum="D9743D5167C12FC0" modified="2010-05-18" version="1">MLSYDNIKALAIFFAPIIIPKAIALFRSVYSHLTNRPPPQALPTLASRALNSLFFSTALFLALSLTPGSNILSSTSSGTNDIFKLTGSRFNTPTELLFSRLRRLGGRFEVESEHDSTLKKLFSSHTARGVYLQLGSEPLIACPFCSLDSAVTYLLYYLPFNTLVPHLFHFLVIGIATSSSIVGEKTARWRNKFLVGAVALLVIELCVILRATSPLFSRPRSSSDSQRNKWTQLYAQYPDAPTSLHVQLVTLRPLAFTVFDAICAALIYLSATNRLFYTLPTPAEQAQQILSLSTATMLATMSKLQALSVTRSVIARDPELSAKYDAYHRGEGKDGDDWVWQEEEVINAVAKVMNDKALQAGNRTDAKEHEIIDSSEYVDKLTAGLEDPIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ21</accession>
    <name>D4CZ21_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025796.1">
        <property type="nucleotide sequence ID" value="XM_003025750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ21"/>
    <dbReference type="GeneID" id="9582039"/>
    <dbReference type="KEGG" id="tve:TRV_00058"/>
    <dbReference type="HOGENOM" id="CLU_806959_0_0_1"/>
    <dbReference type="OrthoDB" id="4174367at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="383" mass="37462" checksum="9B134317D6253F1B" modified="2010-05-18" version="1">MTGERKGKHKRTANPFWRALLSLFSSSNQLETSHSFILFISSSLFSHFPCWFSFLPFFETTFLRTNFKMRFSIVFSAVMASSAMAAPTIVGGVGNNVPVSKGAVGTVNKVAPGVASRDVVNGIAGGAVGTVHGVASGAAGLKTGSIVNRDLVNNAAGGAVGVAGGAVNQAAGDVVHGATNSKRDIAGQAVGGATGIANNAVAGTVGGTVGSALNGKRDVVNHAAGGALHVAGNAVNGAAGNTVDGATGGALKRDVVGQAANDATGITNGAVKNTAGETTGQVVGNVKRDTLPNLNGVTGVVGTAKNLVGGATGGVAGGIVKRVEGVNNMVSGVTDRTIGGVGSIHQKRELPVVGGVTGAVQGVTGNLLGGAASPVAGIAGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZ77</accession>
    <name>D4CZ77_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="ACYE01000005">
        <property type="protein sequence ID" value="EFE45089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025700.1">
        <property type="nucleotide sequence ID" value="XM_003025654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZ77"/>
    <dbReference type="GeneID" id="9581943"/>
    <dbReference type="KEGG" id="tve:TRV_00114"/>
    <dbReference type="HOGENOM" id="CLU_048345_1_0_1"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE45089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="314" mass="34132" checksum="3CABF5918E72DFFF" modified="2010-05-18" version="1">MERSKKPTAIPVSSSAPGPSVSVLENRVEASLATGESITVNLFGATVTSWKLADGSEQLFLSEGAHLDGSKPIRGGIPLVFPSKVFGPPPKEHATSALPQHGFARNAYWEFLGKSTSETEGDASVKLDFGLSKGMLSDKFQKDWPFEFGLVYSVTLSPRSLITSLQVQNKGTTSFEFQSLLHTYFRVDDISKMCIAGLQSKSFVDKLRGASTFTEESDAITISSEVDRVYQSLDPATPVIVTSSGKPVFSITREALTDMVVWNPWIEKAKGMADITPDEAYKNMVCVEAGSVSGWQTLEPGDMWEGGQTIRCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZE5</accession>
    <name>D4CZE5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000012">
        <property type="protein sequence ID" value="EFE45025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025636.1">
        <property type="nucleotide sequence ID" value="XM_003025590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZE5"/>
    <dbReference type="GeneID" id="9581877"/>
    <dbReference type="KEGG" id="tve:TRV_00187"/>
    <dbReference type="HOGENOM" id="CLU_084297_0_0_1"/>
    <dbReference type="OrthoDB" id="5316634at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055117" evidence="1">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE45025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="288" mass="32099" checksum="2DEA64D3298A1C54" modified="2010-05-18" version="1">MASALLPKLYLLLSLLSVVFADAKTGPYLAYIDSDDKPVTVTSIKGSDEYRAFMEDTERNEGVIVTKEEVLNILGEPRNITAISVPQYFNDSSMGMIFSAASDIENSIRYWQVKKQFYLGRFAYGLSSCEGFGLDPKNCNVEDDLPPIIFVDYNEEYLQIMLAEVGEFTFGDLYSVRLPSLGAKRLLDNNLDEYRLELQSAIQDFKDRVSVVYIDSVGEIVMSGEAPKPAFEIIRDAIAAVLPHHVGMIRDSIDPLFTDAVGAAEFAKILVLDPEDSHVDVCNLHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZT2</accession>
    <name>D4CZT2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000016">
        <property type="protein sequence ID" value="EFE44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025562.1">
        <property type="nucleotide sequence ID" value="XM_003025516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZT2"/>
    <dbReference type="GeneID" id="9581800"/>
    <dbReference type="KEGG" id="tve:TRV_00325"/>
    <dbReference type="HOGENOM" id="CLU_043196_1_1_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46163" checksum="8AF22B997709383D" modified="2010-05-18" version="1">MSKAKGSPLSTKWKPRGSQKSALSLKEKAKVLSQLGSITWQLSQLRFEKIGSLFEEEDGHFRVGSCLSRGLVDFDRDSLDELPRGPFSCENEYVDALVLGFLQHAECLQLHHHCFFAPLPTRKRYNNDREYRRACEQWNNFVTLGSKIDGSDNRTDYIVVGNFLRAIASKWTMKGAAAGPRDTNLEFTLHHPDLNVNNIFVDDDCTITCIIDWAFCSSVPLSVLLMAPGLPQSRDELEAPLIAAFEDGLSRSISTGDIISSRLRAFPSRRFLWLFYRLVSFDSSGDYSQFKEIWRLSDQNNLDFSTFFQSQQRSDSYIKKHDEMKQDDESIDRVMRREAAYFQRDMVGLTVSRKLTLVSEWTSRYRKNDNKGIRRSGSIFVADDRLWKWVLRSLEQVEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D025</accession>
    <name>D4D025_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_00419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025358.1">
        <property type="nucleotide sequence ID" value="XM_003025312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D025"/>
    <dbReference type="GeneID" id="9582969"/>
    <dbReference type="KEGG" id="tve:TRV_00419"/>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="582"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="871"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="980" mass="108029" checksum="B1E04D3F66A5446B" modified="2010-05-18" version="1">MKSFIQFVTAPTSDTPGTTLFLHYDDKRYFFGNLSEGTQRACIENNVRLSKLSEVFLTGKTTWAGNGGMLGMLLTLSDTMASASGAMVEAESRKIKNLEERAKAAVRPKDADELMARVKRRKLELEALPEFHGQRAISLYGGPNLTHTLATGRTFICRTGVPIEIREFGCLGCEERDATIDISKPAWSDDHIKVWALPTYPSSSPRLQPGKRTLDDFEGGGRAGAAATKAAREKDLVTRQKIVLDMFNSQWRLDTLVETPLAEVSLPATLFIRDKETGEVKPYEGPKPGDGEALPNINVLVRQPWPGAMVESLPATTPSDCAVSYIVRGHDSRGKFDRKRAESLNIADKSDFRRLASGETVISADGKTITPDMVLGETRPGKGFAVLELPSVDYIQSIINRKEWDNAEVMKGMEVFIWILGPGVGGHPLLQEFVTKMSKYKHIVSSPDYCADNYGFPAVSTATLELSAIDGDRYQKTFCNGEAMLPVSAFAAADTKTSVSIAQPNLTIDLEPSVKLTASPTPPSKPIKMPRRNSYSRVMGEILSQPGVQKRIEKLKASIPNGDAEIIALGTGSSCPSRYRNVSGTLLRVPGHGNYLFDAGEGTLGQLKRTFGPDELKEVLRDLRVIWISHLHADHHLGTVSVIKAWHEAVYGPLSSSPSYMDITEEDVPRILKEKRLYVVSAQHMLQWMAEYTNVENYGYDKVVPLSASSFEHPDGKTDYTYTIHRRQRNGAAIPDSDGKYLGIRLKFDDENSPLTELLKQGTGLDAILTTPVSHCQGAKAVSFIFPTGFKVSYSGDCRPSTRFIDMGRGSTVLIHEATFDDNMLSDAVAKRHSTVSEAMTVGLRMEAKVIVMTHFSQRYRKMPDIANAKEVHIQPPKGWNNKGNTAEDKKPRQAPSVVRDIPTSEDVEEDYTMAETENSGAAKVTRPRSRSRSKSPSSSTNNPPIVIAFDHMRLRVADAIQAEAHQPLLTKFLETTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4D097</accession>
    <name>D4D097_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000025">
        <property type="protein sequence ID" value="EFE44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025312.1">
        <property type="nucleotide sequence ID" value="XM_003025266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D097"/>
    <dbReference type="GeneID" id="9582929"/>
    <dbReference type="KEGG" id="tve:TRV_00492"/>
    <dbReference type="HOGENOM" id="CLU_3088985_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="52" mass="5843" checksum="13F06C6627BEC1E6" modified="2010-05-18" version="1">MAKTGKTTEIRVSSNCDRAKLVEYPPIGMKQSWAKEKREEEEEGGGQAARFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0N6</accession>
    <name>D4D0N6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000037">
        <property type="protein sequence ID" value="EFE44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025204.1">
        <property type="nucleotide sequence ID" value="XM_003025158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0N6"/>
    <dbReference type="GeneID" id="9580697"/>
    <dbReference type="KEGG" id="tve:TRV_00631"/>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="40015" checksum="B0A8DCE233EF79E3" modified="2010-05-18" version="1">MAKNSKRAPKAKAFAPSDSSAKSSSKSDSFDVPAAFTQAPSSLKGFLEPLSTSRIYLIHIDTHPPGFRRQIFLVPLSINIVIVAFILYRIYTGLHMYPDIFNAVVSGTGPAKIDTASASWGFLSSTLAWRTLNFLLDYILATIFLPWPVRFFLGPIRWRLAVRFEPQEIIVRQSREWSESLRPGTWIRDDEATMKDRVIPAILPLRLQKTGYLLIDADWDLDCDAMVNAHKVVEFKKAKLEDFHTAVLVHGGPSKGWLIWRVEDEAVAASGETLPPAARDRIIAFKEKLTDMGKEDLFYRWVEIIQYESTRPGGFTPERQRSAMIEVKELFEKEGVDFDQFWKDIGGMEGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>D4D195</accession>
    <name>D4D195_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_00843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000050">
        <property type="protein sequence ID" value="EFE44427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025038.1">
        <property type="nucleotide sequence ID" value="XM_003024992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D195"/>
    <dbReference type="GeneID" id="9580530"/>
    <dbReference type="KEGG" id="tve:TRV_00843"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE44427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="488" mass="53834" checksum="3B6E1E7900FE6DA0" modified="2010-05-18" version="1">MGSEKSEKTGVSPAGADDQIERTKTEDGMDEKVAVEDRDYAGAVTKLSTEEVKLVRKLDWRIMPTLTFMYFLNYIDRNTLAQARLNNLEEELGMHGTQFNTTISILFVGYVLTQVPSNMLITRVPPSLYMSAWMLVWSAVSACTALVQSYPGMVVCRFLLGITGAPFYPGATYILSIFYTRREVAARIAMLYAAQILATGFAGLIAAGVFSGLDQVRGLSGWRWLFIIEGSVSAAVAIAGFWLLPNTPLTTRWLKPAERELAHERIQRDKMGEPEKASTMQGLKQAVRDPRTWIFCLMQNFHLSACGFNSFFPTVVKTLGFNTTITLVLTCPPFLFAGAAGVLFGYTSGRFHERTWHITVGLATAIVGFVIAASTLNTAGRYVACFIFPIGAYSVNSVIIGWASSTLSQTREKQAVVLAMTNVGGQIGYIYGAYVWPNYDSPRYGIGFGTSAGFALFSILCAWWMRYLLKKENKQLQGTGTSTNLYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1M9</accession>
    <name>D4D1M9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024846.1">
        <property type="nucleotide sequence ID" value="XM_003024800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1M9"/>
    <dbReference type="GeneID" id="9580324"/>
    <dbReference type="KEGG" id="tve:TRV_01011"/>
    <dbReference type="HOGENOM" id="CLU_040048_1_0_1"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="38986" checksum="D3872B5BB64932A9" modified="2010-05-18" version="1">MDDIIRVCTYHRRDFDLAVTRLNPRVHDAVQDSLARPFNRPAVKTLGRMQVLPLEIVFEILLCLDLRSLFVFREVNLRARQVASAVPGYQPLITHALQAICVILRTKIAAWYTLKDVFNVLCTRDCPQCDAFGGFVFLPLLERCCLRCLTSSPRFRVLPAAEIKKLLGISQAHLRQSVPLLHTIPGIYSMDESSRKRRMYIVAVKQVFTAYTFPRTSASVAATAPASRAHAILRYMAGTTLPYVNIESGEIQRGLCCSGCQILIEGGTTPNPTEDLARRDRVYSKTGFLDHFPRCPEAQKLWKRSKEGKVAVKLPMSIIRGGYFSERDVIMSYSKRKYSDLQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1T6</accession>
    <name>D4D1T6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000059">
        <property type="protein sequence ID" value="EFE44188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024799.1">
        <property type="nucleotide sequence ID" value="XM_003024753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1T6"/>
    <dbReference type="GeneID" id="9580289"/>
    <dbReference type="KEGG" id="tve:TRV_01038"/>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="296" mass="33280" checksum="E412F152FC70A4D4" modified="2010-05-18" version="1">MAASNGTQSSFPSPEATPPSSITRKGFRITTKKLPILKAGPIDEMTNKLGIAPPEMIFGDNLVSIEHIPSGWGINFNAFDALDRVDKTGASMLKVSYSGEWQKSRCAISGSSCLYACYFSTNTWNRESAHEGIKEVVKPFDWSYTTDYKGTVTPKGHEFEQTSTPLPIERLKQPDPILFYDEIMLYEDELADNGITMLSCKIRVMPTCLLLLTRMFMRLDNVLFRLRDTRVFVDFDTGEVMREYLAKEEGYDKVKEMIGGSRKDVPAMMRDPNHIAQILPVVDSSLERVVLPPQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X7</accession>
    <name>D4D1X7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_01079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000061">
        <property type="protein sequence ID" value="EFE44119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024730.1">
        <property type="nucleotide sequence ID" value="XM_003024684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X7"/>
    <dbReference type="GeneID" id="9580220"/>
    <dbReference type="KEGG" id="tve:TRV_01079"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE44119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="293" mass="32022" checksum="85FF92F6907F52A5" modified="2010-05-18" version="1">MAPANNGESIDALKDLINSLESRIVGLEKALLNGGHSDSNSAAESMRMILMGPPGAGAQDQGEILRVPLGMSIFANRLVYTLVSSIVALTTMYKSTGDMLRSQVSRQTELGKAAKKIMDQGGLVSDEIMVGMIKNELESNKECKKGFILDGFPRTVAQAERLDDMLRERKQALQHAVELQIDDSLLVSRITGRLIHPGSGRSYHKIFNPPKKEMTDDITGEPLVQRSDDNAEALKKRLATYHAQTAPVVGYYKKTGIWSGIDASQEPGQVWKSILGVFEQKQSPILSKIGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2L5</accession>
    <name>D4D2L5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall proline rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000073">
        <property type="protein sequence ID" value="EFE43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024490.1">
        <property type="nucleotide sequence ID" value="XM_003024444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2L5"/>
    <dbReference type="GeneID" id="9579712"/>
    <dbReference type="KEGG" id="tve:TRV_01320"/>
    <dbReference type="HOGENOM" id="CLU_007264_0_0_1"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="952" mass="102103" checksum="E017285F22777F38" modified="2010-05-18" version="1">MTSISLGAHQPSSHWNTASHIHLHSPESPSYDTRMNPPSSPLPNPPFSFPAQAPSSTDTSRVPSGIPSNNMSSSSRRGRRQPPASLPSFSFPQAPPESVSSTSPTTAAAVAAAGSAPTTKTIPTAPASPVLVEPAHLNAKGHRRQPSEFLGDASSQVAISSSKATASTLPHPGPGLTTGPGRGARRHAHRRSQAISSVDLTVVAKAFPPVPVSGSVPTSPILPFANDKNSKLSSRSFPEMHTAQTSPQRVEQQHQQKLQVSPTRRPYKEESITTATTATTTTASEVAPVSCRPLSTISSESSVSTVRPNQIFSDRSGSGQRSGASSPLHNSNESTARPKTAGAQLAMKWKPFGPSSDNNEHTKRPLSASASMALNFSLGNVCRSQDAERTASNSSSSTTNAQAATPSDQDMEDAETSTLTQRTAHERKPSKKQKKKRSWAGILIRKGKKRSSKKSRKSPTPPPMLTRTNSELGSMYSVDFDHDNTIVIRTPTAQNAPRSHPQSGEPASSTDNSLEKAWTPKSFYEQQSNPDIFSPVIDLDAALGPFNTPEMGPERNITSGFMIASKRMYSGGRRGEFVGPEMRYHRRAESAPEMPPFDRSFLGASRFGLSTAMENPDVFDEEEEDAFLAQNDDQANQKNAESFEADDDAAENDSSSSGEEEEEDEEDSDVEEAGLGIQVVDSSNLPDLYPASVESRPSTAQVITPRTPYAHAIDFESQSQRSNSNSTTYHHPGSIGIVGSDSGQASPRNFDEKRPSTSPEFIYNISNATNLTPIPAIIPPVPMIPQAFPSPAPSSTSFDVPRLNTASSSMTDRHHSSGSVYSGEPGSDYLQNSSEDVPSLTSSASTMTGNIPRLPSAIYGRIPGDRAASFSHVLQLNSAANSAGSNGHSNNNRPSSSKRSSLVSFSRLVGANSERSKLSHEEKAPTDESEKRKKKGLRITRLMQFWKVKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>D4D325</accession>
    <name>D4D325_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TRV_01482</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024345.1">
        <property type="nucleotide sequence ID" value="XM_003024299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D325"/>
    <dbReference type="GeneID" id="9579484"/>
    <dbReference type="KEGG" id="tve:TRV_01482"/>
    <dbReference type="HOGENOM" id="CLU_009273_7_1_1"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="79"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="503"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFE43734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="738" mass="81701" checksum="8D2F989C3779BAF6" modified="2010-05-18" version="1">MAAHCSRIAGRARYPGISLKSQCLRRYSSGCGQAVPKEPSFRPPSLDVPPRPSPELQSPSSRLDSLKDARPFSSFLTDTFSRQHDYLRISITERCNLRCLYCMPEEGVPLSPPEHLLTTPEIVYLSTLFVSQGVTKIRLTGGEPTVRKDILPMMQEIGKLRRDGLKELCLTTNGISLHRKLDSMAEAGLTGVNLSLDTLDPFQFQIMTRRKGFEAVMKSIEKILELNKRHGAGIKLKINCVVMRGMNDREILPFVELGRDKALEVRFIEYMPFDGNKWSKGKMFSYQEMLDVIKAKYPGFEKVPDHKNDTSKTYRVPGFKGKVGFITSMTHNFCGTCNRLRITSDGNLKVCLFGNTEVSLRDMIRQENNNKPIDEDALQSLNLLESARQAARAEDQGYPVNERERELLHIIGAAVKRKKAKHAGIGILENMKNRPMILIGGHWVPQISTTITKISFAIDETTPRNIHHYNHHPAVKRRARTLVSSLRSWQSIPTHLLGIDRSMGQSPRLYSTRKSSTGVELPPSASSQSKPTKDNTIRDLPTASHAKLPHLTPNETVHMTSIGHKPETNRLATAVCRVTFSNPTPISLLTTGDGLMKKGDVLSVARIAGIMAAKKAADIIPLAHPGLGITGIEVDVTVCPPHPEGSMPNEKNRVDNGVHGSILVTSSVSCLGRTGVEMEAVTSVLGAALTVYDMCKAVDKGMVIGEARVVRKRGGKSGDWEEGIRVRDSKENSNEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D337</accession>
    <name>D4D337_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_01494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000079">
        <property type="protein sequence ID" value="EFE43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024357.1">
        <property type="nucleotide sequence ID" value="XM_003024311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D337"/>
    <dbReference type="GeneID" id="9579496"/>
    <dbReference type="KEGG" id="tve:TRV_01494"/>
    <dbReference type="HOGENOM" id="CLU_011501_0_0_1"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="326"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="780" mass="85789" checksum="4B6B70C91B98962C" modified="2010-05-18" version="1">MASPASPSAIAAEEEEEPVTLNSVAEKDLTARCKPRTIAYCPNMDLVAVVTEDEQVNVYRLNGQRVFGGAYGLGEEDGEKGVVRAVVLRWKENGRVLAVACSDNRIRLLSSYSGKMVHILTAEPAQAPFSSPQRPSGSISCIGWGVSFAETDSLLKNLKDPEGKLSLDDLLMSDTKLSTHLGFLKADLPRELALLDIEGSLPKLSTLPSTGDEYVGRLPLVDSIHANGISSDDVFSSRVSLDSIFHSPVKNPGDSVDVLLAGLDDGSIHMRIFESFEIGSIDVSSSLDGSDSDTGEGGGYKTLLHASHPMSTTHALLFQSEAGMKLLNLDLRFITKAGRYLPLLASKVTQLQNLLRYIKQVQAQMHLEWKNARELPIRYLRNINEELKEQCHCDFVTATYHLIVTGDCYAPLKEFLATTISDRGQKRWEKTVAGGYEALRRLAYECLMPALERCGVLLSRLIGLSKYHRISPILGLETTYLKACVATLDCLTLLAHKVVLHSSTELKEFHAFSHWMQHEIKLQSTDPTSSTIDELVEAADEIDYGTTLGYVKGALTNSALQGFLQVPPPPGAPGAPGADPEDRKRWDVDIQDDGTFYEEYKKVVSQHESQRSAEGLSIPMLGDLTARLSAECDQVFKQIAETQRRGTLFRSALKLNEDCDATFLDMAMNFEVSVRRLVFRVKLADGVSQEYEGESLPSIYAASRSRTTAHKFYIYRHILSVVNGVSSTKASLQATVELGSGSIQDLKFVEDGTLMLLWKSKGMFLLVVFLLFTCSGLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3N8</accession>
    <name>D4D3N8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000086">
        <property type="protein sequence ID" value="EFE43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024140.1">
        <property type="nucleotide sequence ID" value="XM_003024094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3N8"/>
    <dbReference type="GeneID" id="9577137"/>
    <dbReference type="KEGG" id="tve:TRV_01698"/>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="440" mass="49725" checksum="A5879E7666006ED0" modified="2010-05-18" version="1">MASLSFTLLPEALMQLRDVLICLSKFNETVSIEAEPDCLRLSTLNVTKSGYASYRLDAPSFFSQYSYNTPLNKDKNGKDKISCQIYIKALLSVFKGRAGDFKDKDTAIEKCEAQLFDSPEETECRFVVQMICKHGVLRTYKLIYEPADVQHAIFARSDSQNQWSVDSRFLREILEHFGRGAEHLDVYCEDGRAVFTSYTEKVIAGTEILKQPVHTSVAIETRDFVHFSVEEGLHVAINLRDFRAVILHADTLKVPITARYTRPCRPLQFSYGIPEMTCEITLMTRGEGIDETESVPSQSNGVREVPARPAQQVAVSVSAGGDGVAREQQQPTQVHAQVQPEPQISMLPPASHGQGTKQITSLAPVAPIDHESLFVAADDDRQWDEPQYEEEEREDMLRWDSNLDQVKTFLMPIDYLILMKSLVIGGLAAEYRRHYPRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D3Z7</accession>
    <name>D4D3Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 5-phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_01810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000096">
        <property type="protein sequence ID" value="EFE43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024043.1">
        <property type="nucleotide sequence ID" value="XM_003023997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D3Z7"/>
    <dbReference type="GeneID" id="9582736"/>
    <dbReference type="KEGG" id="tve:TRV_01810"/>
    <dbReference type="HOGENOM" id="CLU_025224_1_1_1"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="439" mass="49682" checksum="FEF75DE7E55039DC" modified="2010-05-18" version="1">MLTSKSWLNAYILTFNCARNTIDTQIFASHLFDGLPKDSDPVSYPEVLVLSLQEIAPIAYAFLGGSFLEWYFDAFRLAVDLATPEDQRYQNVLTKNVGMTAIMVFIRDDYVDRIAWKEEAEVGVGVHQAGNKGAVGARIGYQVDYDSEDQLPLTFVSLHLAPDESAIDRRNQDWKDICQRLVFTGCDVAGQSGRQHRQYDEEGTPLIPSYHGSERGSGMYSPNTYLFVAGDFNYRTSHRDPQPGDIPAFPQPTNDTSSRNHYMHLLAHDQLTRERLANRTMHHLSERPITFPPSYKYSLEAREGSLHHPEEGFKWAKNRWPSWCDRILYLENPFPGDESQKVQVHHYGILPLFQTSDHRAVVISLSVPLKTPPALQDSSAISPPFDIDHDWRSKRLIARKKEIAVGTMAYLALTWEGNGLILATILGIAAGYFTLYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D4A5</accession>
    <name>D4D4A5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_01920</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000102">
        <property type="protein sequence ID" value="EFE43314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023932.1">
        <property type="nucleotide sequence ID" value="XM_003023886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D4A5"/>
    <dbReference type="GeneID" id="9582629"/>
    <dbReference type="KEGG" id="tve:TRV_01920"/>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055224" description="Ribonuclease T2-like" evidence="19">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="20">
        <location>
            <begin position="279"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="412" mass="44152" checksum="FF071E087E3B078B" modified="2010-05-18" version="1">MLASSTTAAVVLAASQLFSGVRADGPTCPPGGEVSCHNSGPVGDTCCFNTPGGLILQTQFWDADPATGPEDSWTIHGLWPDNCDGTYEQFCDMSREYSNITQILQAQGKHDTLEYMMKYFKDYKGDDETFWEHEWNKHGTCMSTFETKCYMDYMPQQEVGDYFTKLVELFKGLNTYKTLADAGITPSNDKTYALRDLQAAVKSSFGMEITFNCKNGALNEAWYFYNVRGSAQTGEYIPTLPGGSPSTCPDTGIRYLPKKSGGTQPPTTTTPGSPAPTGTFSGKGYLTVTVMGEEDGCLISSGNWYTTGTCATYRAAASGSGFTLTSSKGACGMVNDQFKCGSGVTASVFGVCLPPSFPCQILLLTISQASEGKLAASGKSTFYADKIPSGSTQAPVYTAPRAIPLTVSWQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D550</accession>
    <name>D4D550_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TRV_02220</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000118">
        <property type="protein sequence ID" value="EFE43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023645.1">
        <property type="nucleotide sequence ID" value="XM_003023599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D550"/>
    <dbReference type="GeneID" id="9582191"/>
    <dbReference type="KEGG" id="tve:TRV_02220"/>
    <dbReference type="HOGENOM" id="CLU_053569_0_0_1"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFE43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="294" mass="33119" checksum="FE1E14208D184598" modified="2010-05-18" version="1">MHGDGWTTLKIYPYIAMDHIIPHVCTILLAARLMVYWLGKINFILPDPYLDEVFHVRQAQAYWDHRWQQWDPKITTPPGLYLVSYAVASLSAALFGKPVELSASVLRCINGLVLFNVLQFTLRRFFSLRQALMLEKGEVRVSTWSISLSALNICLFPPIFFFSGLYYTDLAALLVVLEACNVDLERSSFADGHGTVKGSLRMTLEYLSLVVLGLAALVFRQTNIFWIAVFLGGLQVVNTLRSRSTECQCSDMQRIARGSWELNQLYDPPAAAAYTEGNACMPMMSLGVRSITPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D657</accession>
    <name>D4D657_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_02580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023246.1">
        <property type="nucleotide sequence ID" value="XM_003023200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D657"/>
    <dbReference type="GeneID" id="9583266"/>
    <dbReference type="KEGG" id="tve:TRV_02580"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="271" mass="30705" checksum="2678037F2BAE8575" modified="2010-05-18" version="1">MRKKPKEGKSDFEIGKKTSGRQRANPHHKNSFKYSSGRLFSSCLKSQSQLLDYSHNEKKRNFVETVELQIGLKNYDPQRDKRFSGTIKLPTVPRPRMSICVLGDQHDIDRAKHLGVDAMSSDDLKKLNKNKKLIKKLARKYDAFLASDALVRQIPRLLGPGLSKGEYSHIRIFRYEDRSTNLTIAGKFPTPVSHNEDLSNKMNDVKSTIKFQLKKELCLGVAVGNVGMTEDELIANIMLAINYLVSLLKKGWQNVGSLTIKASMSPPKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D661</accession>
    <name>D4D661_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">COPII-coated vesicle protein SurF4/Erv29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023250.1">
        <property type="nucleotide sequence ID" value="XM_003023204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D661"/>
    <dbReference type="GeneID" id="9583283"/>
    <dbReference type="KEGG" id="tve:TRV_02584"/>
    <dbReference type="HOGENOM" id="CLU_056195_2_1_1"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24217" checksum="E1831ED34B04E484" modified="2010-05-18" version="1">MVLTYHAVPWGITHLFLIVNVVVMLSCSVLVIARKHSEYAVAGLLGVVVAQALGYGLLIDITFIVRNLSVIGGLLMVLSDSWVRKKFMPAGLPQLEEKDRKMYVQFAGRVLLIFLFIGFVFSGEWSLWRIIVSCIGLVASVMVVVGFKAKWSAVILVVVLSVFNVLVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLVLLVNMGPGQLSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D686</accession>
    <name>D4D686_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TRV_02610</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ACYE01000134">
        <property type="protein sequence ID" value="EFE42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023276.1">
        <property type="nucleotide sequence ID" value="XM_003023230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D686"/>
    <dbReference type="GeneID" id="9583295"/>
    <dbReference type="KEGG" id="tve:TRV_02610"/>
    <dbReference type="HOGENOM" id="CLU_003376_0_0_1"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="27">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="26">
        <location>
            <begin position="164"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EFE42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1052" mass="110231" checksum="5FBC06CFF0EE8013" modified="2010-05-18" version="1">MNNLTSLRRAVVSFGQHARFFSCSSQYYQQQQQQSDSKIKTVPYSSLTIGVPLESYPSERRVSLTPANAALLLKKGFGQVLVERGAGAASQFTDKAYIDAGASLVDRHDVWESDIVLKVRAPSLNRGEVGLLKDGATAISFLYPALNRDLVEALAKGGVTAFAMDMVPRISRAQIPPGKVLVIGAGVAGLSAISAARRMGAIVRGFDTRPAVREQVQSLGAEFIEVDIQEDGSGAGGYAKEMSKEFIEAEMKLFLQQSREVDIIVTTALIPGKPAPKLITEEMIMAMKPGSVVVDLAAEAGGNCVLTKPGELVLSSNGVTIIGYTDLPSRLPTQSSTLYSNNITKFLLSMAPVEKQFGVDLEDEVVRGSIVTHAGSILPPAPRPAPPPQPATPKKDDAALSADAAKMELTPFQKVSREVATVTGGMGTALALGKFTGPLFMSNVFTAGLAGLIGYRVVWGVTPALHSPLMSVTNAISGMVGIGGLFVMGGGYFPETIPQALGALSVLLAFVNVSGGFVITKRMLDMFKRPTDPPEYPWLYAIPGVLFGGGYLAAVSTGMAGLIQAGYLVSSILCISSISGLASQATARAGNSLGILGVASGILASLVAVGFSPEVLAQFVGLAGIGGLVGAAIGRRITPTELPQMVAALHSVVGLAAVLTSIGSVLADIDHVSTLHLVTAYSGVVIGGITFTGSIVAFLKLSGKMASKPLAFKGRHIVNSSLLGTNMALMGGFISMAPGAPLVAAAALSASTILSFIKGFTTTAAIGGADMPVVITVLNAYSGFALVAEGFMLDNPLLTTVGSLIGISGSILSYIMCVAMNRSLTNVLFGGISSPTQAQSDHQIEGKITKTSIEETAETLASAESVIIVVGYGMAVAKAQYAISEITRMLRAKGVKVRFAIHPVAGRMPGQCNVLLAEAAVPYDIVLEMDEINDDFGDTDVTLVIGANDTVNPIALEPNSSIAGMPVLHAWKSKEVIVMKRGMSSGYGKLLNSSLTKRDPFKLTYPIADVPNPMFYMPGTKMLFGDAKTSCDDQLDHLFKDREDIFIYPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6H1</accession>
    <name>D4D6H1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_02696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="ACYE01000141">
        <property type="protein sequence ID" value="EFE42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023174.1">
        <property type="nucleotide sequence ID" value="XM_003023128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6H1"/>
    <dbReference type="GeneID" id="9583194"/>
    <dbReference type="KEGG" id="tve:TRV_02696"/>
    <dbReference type="HOGENOM" id="CLU_011226_5_1_1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="93"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="228" mass="25716" checksum="C4A3E3975F58150E" modified="2010-05-18" version="1">MPQFTLYANPIATAPDRILLALADAGFTDFEYVNVDMSAKEHKSAEYLARNPFGKVPTLVTSDGVTMYESRAIARFLCTKLNLPLLPNPATATAASLALFEQELSCEISYFETPVSGIIWETFIKRVIGMETDNAAAAEHKKKLEEYFDIVEAKFKTSGKKFMAGEEYSLVDVYYLPFLARLFDRGFGDVVTSRPQIKAWWDRCMERPKTKAWIDQSPKLDAILASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D6Z2</accession>
    <name>D4D6Z2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_02870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000147">
        <property type="protein sequence ID" value="EFE42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023048.1">
        <property type="nucleotide sequence ID" value="XM_003023002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D6Z2"/>
    <dbReference type="GeneID" id="9583068"/>
    <dbReference type="KEGG" id="tve:TRV_02870"/>
    <dbReference type="HOGENOM" id="CLU_1662079_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="159" mass="17903" checksum="8C5F1A0561472222" modified="2010-05-18" version="1">MHRRRERASARHSLEVTGQLTDAELDNEEDGVNDEEEDDPLRLGQSHPAVVAVAVATVVVAWSILEKRRKEAKKKRRSAARAEQREEARKKKKKKKRRSEEEAKREDETPAGVVYKVEVRQIKRAADQARPGQRKKEAAKQASAAAAFRIGATALYQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7L0</accession>
    <name>D4D7L0_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000159">
        <property type="protein sequence ID" value="EFE42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022796.1">
        <property type="nucleotide sequence ID" value="XM_003022750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7L0"/>
    <dbReference type="GeneID" id="9581473"/>
    <dbReference type="KEGG" id="tve:TRV_03093"/>
    <dbReference type="HOGENOM" id="CLU_031753_3_0_1"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37489" checksum="24C90CC1D93E69D7" modified="2010-05-18" version="1">MAQQQDTHFAFLPLGAIIQEFRVAGKNIVLALPDEEAYRKYNAPYFGSTIGRTTNRLKDSVVKNLNDKTYVITSKEGPNSLHGGKEGWNSRVFEGPKPVHRKGRESVEFRYTSRHGEEGYPGTVELRVWYIAGKQDGKTELEIEYEVEFIGSECEETVVGVTNHSYFNLSDDRTINGTEAVLSTDKYLPTDSTGIPLGTIESYGPLRVTEPFVIDDKCPDFDSCFIVDTHPQDIPLDTRPRDLKLLASFKHQESKMHLEVLSTEPAFQFYTGQHVDVPPVGKYPARGPRSGFCIEPSRYINAPNVPEWQKMCLLKKGQTWGARTLYRSWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7R7</accession>
    <name>D4D7R7_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000162">
        <property type="protein sequence ID" value="EFE42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022728.1">
        <property type="nucleotide sequence ID" value="XM_003022682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7R7"/>
    <dbReference type="GeneID" id="9581417"/>
    <dbReference type="KEGG" id="tve:TRV_03151"/>
    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="605" mass="66675" checksum="5889A4BF7D6D802E" modified="2010-05-18" version="1" fragment="single">MDITGFIVTHRAEALSMGDYNKYRAMLTRRLHTLNKRLGRTTPKNKKFSGKAAITSSDIAKDHGYVRILLLSAERAWAEAMHMRSVHSQDTSKKGMVGSARRHIISRLTKSTVYARQLASALQNQQESGASRTDILEAHAYLATLMTTCWMERRQWENCLKQASLARVLYAALEKQDKQGNIQEVISGTVDPSIRYSAYQLKIPRSVPLSTIAKKYFPADSPLRGEVEAIDPHCLSEDTAEGGPDAAAGSGDGQTFPQTITWRSRTVKIEDSAISQALASAASAEAQLVAWIAKQGGQKASAKETAANYDNVIIASQDAVDATKAAIDELTSEGIDQGDTRMQSLQITKTAVNYRLVRWRVGRNRVLCGDADGLSFTPPAAARRKGKEEDGAETPKQESLGRRIGRLREHVVLCDSILQSLESVKELPGVAADAAFVRELEAKLSYFKSLRCLAIGRSYAFRSESKNALALFIRADELVSKALPSCSEETDASSHPLGVDVTRSQAEELHVQLEHLVWQYRGIVEIEKLAAESDQRDPATLPPVVRRMQEYHLDGVDLSNLVAYPPRLEPIPVKPIFLDLAWNYIQYPMEKKKGILPDTAGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7V9</accession>
    <name>D4D7V9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_03193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000164">
        <property type="protein sequence ID" value="EFE42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022672.1">
        <property type="nucleotide sequence ID" value="XM_003022626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7V9"/>
    <dbReference type="GeneID" id="9581331"/>
    <dbReference type="KEGG" id="tve:TRV_03193"/>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE42054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="322" mass="35126" checksum="874BF65525747CF7" modified="2010-05-18" version="1">MPPRLPLRLLSQSVSLISSSIQSHVSPSFLFLLPSIHTQTRAASILASLSDNPGAYSKKIRRGLGPASGKGKTAGRGHKGQGQRGSKKAFFNGGQTPDEVVHGERGFDNIFALKISPVNLDRIQDWIDQGRLDPSQPITLRELVKSRCIHGIKDGVKLLSRGGEGALKQPITIIVSRASASAIQAVEAAGGSITTRYYTRHAIKRILSGKTDPYVSLAWKDTSEKLAEAAAKGEDVSHIDTELMQKIGMGVDKPLTKGNGFQYRLPDPTSRRDIEYYRDPAHRGYLSYLVKEGDSPSLFFTPPSAEQKAKKAVKKSAENRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Y1</accession>
    <name>D4D7Y1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">TRV_03215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="ACYE01000165">
        <property type="protein sequence ID" value="EFE42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022655.1">
        <property type="nucleotide sequence ID" value="XM_003022609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Y1"/>
    <dbReference type="GeneID" id="9581313"/>
    <dbReference type="KEGG" id="tve:TRV_03215"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="404"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="816" mass="90475" checksum="AD832595D7CCEC00" modified="2010-05-18" version="1">MALFPLRLQINYEEEKTVLKEFLQNFKSSQSASEASATEAISGLNIDEDDLDALDEMDEDGEENGQTTRERREPKLKYMALLQEIADRTKNHIVIELDDLDKVQSTPDVFMKSAPEGPYSDLAERITNNAKRYIDVISEAIDDIMPKESSEVTFKDDVIDVIVSQRGRRNETLDLNLEADPDADVQASTFPPELTRRYTLNIKPITPSGSSSNPKAKAFAVRDVRGAQLGKLITVRGITTRVSDVKPSVKINAYTCDRCGSEVFQPITTKQFLPLTECLSEECKKNNSKGQLFFSTRASKFVPFQEAKIQEMADQVPIGHIPRTLTVHLMGSLVRQLSPGDNVDIAGIFLPTPYTGFRAIKAGLLTDTYLEAQHITQHKKAYDHLVMDPVTLRKITRHASSGNMYEYLSRSIAPEIYGHLDVKKALLLLLIGGVTKEMGDGMRIRGDINICLMGDPGVAKSQLLKYITKVAPRAIYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDGDRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPLYGRYNPRVSPVENINLPAALLSRFDILFLMLDTPSRDADEELASHVAYVHMHNKHPETSADEVVFTPAEVRQYIAKARTFRPVVPKSVSEYMVGAYVRMRKQQKQEEGSKKQFTHVTPRTLLGVLRLSQALARLRFSERVVTEDIDEALRLIEVSKSSLHQDSQTGMDHSPTSKIYNLICAMRESGAAAIGDEDEGTLSMKRIRERVVAKGFTDDQLSQAIDEYAELSVWQVSGNGTRLVFIEAGDGDAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4D7Z5</accession>
    <name>D4D7Z5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neutral amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_03229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022642.1">
        <property type="nucleotide sequence ID" value="XM_003022596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D7Z5"/>
    <dbReference type="GeneID" id="9581301"/>
    <dbReference type="KEGG" id="tve:TRV_03229"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="403" mass="43637" checksum="43AADA0B9630041B" modified="2010-05-18" version="1">MIAETISLGILSLPSAVAALGIVPAIVIIISLGLLATYTGYVIGQFKMRYPHVHNMADAGEVLMGPIGREILGAAQLLFLVFIMGSHILTFIVMMNTLTDHGTCSIVFGVAGMILSLVLALPRTLKNVSWLSISSFISILAAVFVTMIGIAIQHPGKAVEITVKSDLYHAFLAVSNIVFAYAGHVAFFGFISELKEPAGYPKALYLLQGSNTTLYTVSAIVIYIYGGKDVASPALGSTGPILRKVAYGVAMPTIVIAGVINGHVASKYLYVRIFRGTNKMSQRTFLSLGTWVAITVVLWVIAWIIAEAIPVFNNLLSLITALFASWFTCEFLPIQLNHLALQYENKQLIMGSTDGLSGLFWLYINKGKYFSSPRKIFLTFLNSFVFVAGATIVSVKSRIPKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D804</accession>
    <name>D4D804_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_03238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000166">
        <property type="protein sequence ID" value="EFE42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022651.1">
        <property type="nucleotide sequence ID" value="XM_003022605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D804"/>
    <dbReference type="GeneID" id="9581310"/>
    <dbReference type="KEGG" id="tve:TRV_03238"/>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="529"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="735" mass="82635" checksum="296EE2F4D0434FEB" modified="2010-05-18" version="1">MKKRTAIIVGAGAGGVATAARLAKEGFKVTVVEKNGFIGGRCSLIQENGYRFDQGPSLLLLPRLFVDIFKDLGTSMQDEGIQLLKCEPNYRIWFGDHDRVDMSTDLAKMKLEIERYEGDTGFDQYLSYMKESAQHHDLSMAYVMKKNFTSLFSMLRAEFLFSTLPLHPFESIYSRASRYFASEKMRRVFTFASMYLGMSPFDAPATYSLLQYSELADGIWYPAGGFQGVLEALANIGKRLGVKYLLNQPVSSIQLSKDGHTAVGVKLGSGKTLTADTIVINADLVYAYNELLPISPLGNDLKTRPSSCSTISFFWSFDRVIPELQPHNIFLADEYRESFDSIFNDHTIPADPSFYVNVPSRVDPSAAPQGKDAAVALVPVGHLVDNSAWADDMDSVVSKTRERVIDTIESRTGARGLRDCIISEQVNTPFTWKEKFNLHQGAILGLSHSFFNVLSFRPKTKHDTIKGLYFVGASTHPGTGVPVCLAGSSSKHFLVKQALLETSVVQLSWMQTRYALLLADTMSVTNTPKVVMLRVGERTFHTTAETLTERSDYFKAYFSGKWTIPTMEDGSIFIDADGEAFEHVIRYLRRGVFPLAFDAAKGHNYHLYTSILEEAIYFQCHRLVTWLKDQCYHKCVTWHTSVKEVEGEVEGETMAVMGDGSSRAMSIVRAATKEKKTYVCPREIFSHYGQKWKCGRQCHNAQAGEDIKYDVEHIPLWHILKTEHNFNNEWMTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>D4D846</accession>
    <name>D4D846_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_03281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000167">
        <property type="protein sequence ID" value="EFE42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022624.1">
        <property type="nucleotide sequence ID" value="XM_003022578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D846"/>
    <dbReference type="GeneID" id="9581283"/>
    <dbReference type="KEGG" id="tve:TRV_03281"/>
    <dbReference type="HOGENOM" id="CLU_085444_0_0_1"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="260" mass="28883" checksum="74843DBC7F07D238" modified="2010-05-18" version="1">MTISGIANSTGTSLFLRGKGLCSTTAQHDWVKVCLRDATLMLTMAKLKPEPELVFERKNKNLLKIPKNARIEKRPIPHPPAASPYAGANVPKVVYVSTKSPFMSIAKRVQKLLREAEKRATQSICLGNKRKSSKDKLTQLKNASEALRKEPVFIKATGRAIDKAMEVGKWFDKKDGFTTKVKTGTVMVVDDIVRDEVIEAEKQLTGDAQQTDDQEDVASKADAERKQGKNNSKPDNGDLSDLPDSRTRWVNMVEITITMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8L6</accession>
    <name>D4D8L6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_03453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000180">
        <property type="protein sequence ID" value="EFE41771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022389.1">
        <property type="nucleotide sequence ID" value="XM_003022343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8L6"/>
    <dbReference type="GeneID" id="9580936"/>
    <dbReference type="KEGG" id="tve:TRV_03453"/>
    <dbReference type="HOGENOM" id="CLU_1435412_0_0_1"/>
    <dbReference type="OrthoDB" id="10626316at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="189" mass="21829" checksum="E990F1C205D10C71" modified="2010-05-18" version="1">MYNTSAAYSQDLLLSVTRGLSKISKTDGFVRLHTLEILLCNHLVIEEWAKVFDFTAIKNFSLIHSFNFDVHYPSPWTYLRSRRVTLKRLKTNIYMAGAVSYLRPFNSIEELYLMGSRKSADFGYIGFYFSNLRILLIMEFVIDIGLFVRNLHLLIGACPKLEELGFPLLRKIQLLRNMPFSPHLPTGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8S1</accession>
    <name>D4D8S1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022298.1">
        <property type="nucleotide sequence ID" value="XM_003022252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580917"/>
    <dbReference type="KEGG" id="tve:TRV_03509"/>
    <dbReference type="HOGENOM" id="CLU_001721_0_0_1"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1697" mass="189145" checksum="CA6236D3B8B8F90C" modified="2010-05-18" version="1">MLPSVAHQPLQFLPHRHTQSVYSTNTPYDLHGQGIHSFQDDFQFSQYANHGPSSLIRGSRTHCPRPIQRPEVHNLPDGRLPAGSASQENTLRRKTPNGTLAAGYDATPGDRSIQQPATKHILVSSLDNSQIMPQPGLSLDPLQQFKTVEPLPLSQHQNFPPAFKQDANRINTVHNGIPQEFPNTNWIRSLNPPQGGIDSVLNQTSSLTAGQRYNYWQNLPTVPTVLASSFQPGLGGPESAAAAQYGQYWPDGPYMPPYRPTTFGDTRYQSTPSLGQHSLPTNNRLADAQSLFNRQSLPPSEFLAPGFSWNPLPAQSTINAQQQHQVYAHDLSRPQQHYAPGHIPQKAPDQIWDQPQLQYGSSLPSKHDVHHLDSVDSLRWQQTSQNGLHPSASNVTRSPRNPEFKEKTLSWAHSVYVDLLASLHNARKKASQGADSHSREPLKPSIYPKPPRQPTSDFSHSENMARKSRNHDPQVQAMNMHPQRSHSIHLDQTVGGFFDTKRHPAHRQFPSIDDSAQLRHLNQSFNHGMSSDMSMNGYRTIRRSHGASMSRMFSPAHEAMSISEKAVSALEMLGSLCKESGWTWIDGMLVGGCLAYGLGDYNRAMRWYNRVINQDSTHVEAISNLAASLLALERREEALQHWLRAIKLRPSYFDAVEHLIGLLCSSQRGKEAVNIVQYVENSLRLPPSGDYFKSNRACDQSDTESEDRESSVSTTESADKMAFDYTDSIQSPLAFARRGSDQSTPGFGSSGYAIPGADNGRILGLIHAKGNMLYALGDNVAAAGAFEEAILISTGKRRGMKSLIRHILSSFADDNRRGIPTCRPYDPKETVLLFPDKALQTAKLVFHPHGILPGLQFLPDGLAKRAAISTTSNSLLSLAKIYQDGMASTSSNGTLRSTPGVRDILALYYLSLSLQPSPSTANNVGILLAGIQGTSAKSVRTAGEYQIPDIPGVTPGSGIALALAYYNYGLTLDSRHAHLYTNLGSLLKDIGQLSVAIKMYELAVQCDNKFDIALANLANAVKDSGRINDAIGYYRRAVNANPDFAEAVCGLANALNSVCNWGGRGGISPGRGIRDLWHVDDQGRLRDAKEMTADTGWIKRVVDIVDKQLKDGELWGCGTLQNLTPDQLCSALMSPSSNTTDAMSRRTTLNSLLRSWSGKRWEGSRTVRLIERMVKYIGWQWYQDRYVHRREYPASRYARPNFPGALTPPSAPTVLPFHTFTCPLSAKQIRHISQRNGLRISCSTLRSPWLPATVYPPPAPPNPQIIVGYVSSDFNNHPLAHLMQSVFGLHNPSRVKAICYATTASDNSIHRQQIQREAPVFRDVSSWSVDRLVDQIVRDGVHILVNLNGYTRGARNEVFAARPAPIHMSFMGFAGSLGAEWSDYILADELSIPPSTLAPRGQSARIEDRLYDVDHNEDADDWIYSEKIVYTKHTFFCCDHRQSAPDARAPKLTWEEEQANRWKMRKELFPDLKDDTVILGNFNQLYKIEPTTFRTWLRILAGIPNAILWLLRFPDVGEHNLRQTAKAWAGEATASRIVFTDVAPKHTHISRARICDLFLDTPECNAHTTAADVLWSGTPLLTFPRYKYKMCSRMASSILTSALPQTEDGKQAARQLISSDEVEYEKTAIELGLGMKYEPGSNQGNASGRLFELRKMLYLNRWQSKLFDTRRWVNDLEEAYEKVWANWVQGEEKDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8T4</accession>
    <name>D4D8T4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_03522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022311.1">
        <property type="nucleotide sequence ID" value="XM_003022265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8T4"/>
    <dbReference type="GeneID" id="9580858"/>
    <dbReference type="KEGG" id="tve:TRV_03522"/>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="441"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="799"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE41693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="919" mass="104050" checksum="EEEC28EF9A71DA0F" modified="2010-05-18" version="1">MANESGFRALSFSFLTEPPLSSPTVPQSNDISTNGTTTTQPGISIRYGPATDNEVDMQDADTNGVAPSKRKSRSSAGRPSYVEAESSAEDDKPLSFLATHRLRLIDFLLPLFPHFYSTNRTDSSQSKRRRTVPKPEPSDSDEAPLISQAKKGKRASVNSAEAKRLVAEKADIEKSAEKEAQSLRQQDRQAAAKKKAAAKTAAKPTKAKAATTNGKKALTNGIKKSESSDEDVPLARKAPAKKAAATPAKKSKPAAKKEPSEEAEAEEEEAEEEYRWWEDPSKGDGTIKWTTLEHNGVVFPPPYEPLPKDVKLKYAGVPVTLRPDAEEVASHFGTMLNSTHNVENPIFQKNFFNDFQAIIKKTGGAKDPQGKPIQIKEFSKCDFRTIFEHYEKLRAEKKAMSAAEKKAAKAEKDAAEAPYMYCMWDGRKQKVGNFRIEPPALFRGRGEHPKTGTVKTRVMPEQITINIGKDAPVPAPPEGHRWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDVKGQSDYKKFEKARELKKHIDRIRKDYKKGLKDELMVNRQRATAVYLIDQFALRAGNEKGEDEADTVGCCSLKFEHVTLKPPNTVVFDFLGKDSIRYYDEVEVDPQVFKNLKIFKKPPKKEGDEIFDRLTTSALNKHLSSYMPGLTAKVFRTYNASYTMATLLKKMSATGTIPEKVKQYNDANREVAILCNHKRTVAAGHANQMEKLSDRIKGLQYQKWRIKQMILDLDSSMKKKKGAAYFELDEDLDMEWIKEHQAFLAEELRQKIRKKFDKENEKRAADGEKEMKAKELEERLKAADELEAKYKKENKTKKVEAEGRGPTVEKFEGQISKIDQRIENMLLQAEDKENNKEVALGTSKLNYIDPRLTVVFSKKFNVPIEKFFSKTMREKFDWAIKSVDEDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8V4</accession>
    <name>D4D8V4_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000183">
        <property type="protein sequence ID" value="EFE41713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022331.1">
        <property type="nucleotide sequence ID" value="XM_003022285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8V4"/>
    <dbReference type="GeneID" id="9580878"/>
    <dbReference type="KEGG" id="tve:TRV_03542"/>
    <dbReference type="HOGENOM" id="CLU_028989_0_0_1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="68913" checksum="F179DB811FB4A027" modified="2010-05-18" version="1">MAHPSKPYGFSKPRVNAEVTYAGALPTPLPSSSSGSIPAYRPNRVRRTEGSSESEAPSAMGDSEVYNENFRSGGPHLVRLPALNHHLTQNDPLLVAWEDKLEAPVRVIIKNYNIDIIGVGPLRRFSRRSAEKYDTALVTARKHVVTSDSWFRACKEMLQLFRSKGFMQLNVEIIDTRANTQLISYPVSVSDPFVDSWRVLRPVILEILAESDWTLLYVVRRRHVNHFEGPITVAITVTEESTNDWTAVRDRIVELLDTRGHYNVAVEICRSNIWHASSFDNRVLDRCDWAIKAKPGGSLGPRGSTTSASTFGGFIDLQHPISQEWKRFGMTNFHCVVAGSESHPSYERWVREGIKPGDNSNNLQLDHPALQDDEFSLRHYRKEIDEVQHDVSDNLRQRILSGDPSVSRSQKTIYKRQQATLSEIGETLRIATSFDQQKRYLGSVYAASGFKVNKQRKLLDWALVDVNKCRLTVNEIPPDGTVNSKYRVYTPPQPVMIGTSSVDEGDRVFKVGRRTGFTGGTVNGIRLADLQGWVTNAQGQREYAQGTASVILPWKCDTFGDPGESGSFVMDHEAKFIGLHIGGDRDRNIGFVIEAQDLFEDIKEVTKSRDVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4D8Z7</accession>
    <name>D4D8Z7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_03585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022263.1">
        <property type="nucleotide sequence ID" value="XM_003022217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D8Z7"/>
    <dbReference type="GeneID" id="9576863"/>
    <dbReference type="KEGG" id="tve:TRV_03585"/>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="398" mass="41834" checksum="CD87DA34EE0CFA0A" modified="2010-05-18" version="1">MKVGGNESATKYFQSHGGTAALNSKDSKIKYTSSAAVKYKEELKRRAAQDAEEYPEEVVITDVAATATPEGSSTPAGDPDDDFFSSWDKPSIKRPSNPPSRVGTPSSGGRSSPFLTPGPNGNGSRPKSPLSSTEKGNASSPPVAVRTATAVRKGPAATGKKTSVLGAKKGPKLGAKKVVGAEAIDFDEAERKAKEEAERIAKLGYDPESERAEEEAATKGKSASSIVSPTPISPRTSFGTTRSHDRSASEVERLGMGMGRLGFGQVGKPKAPAPKKLGFGAVGHANSAVDDEELEQTRSKFGNQKGISSDEFFGREQFDPVAQAEAKTRLSNFEGATSISSNAYFGRPEDELPAGDDYGDLETAAKDFVRKFGITAGDDLENLTNLVGDGAVRLHAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4D916</accession>
    <name>D4D916_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022282.1">
        <property type="nucleotide sequence ID" value="XM_003022236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D916"/>
    <dbReference type="GeneID" id="9576885"/>
    <dbReference type="KEGG" id="tve:TRV_03606"/>
    <dbReference type="HOGENOM" id="CLU_2387754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="94" mass="10089" checksum="E3B23A172E1E4D2E" modified="2010-05-18" version="1">MKEFRILITNWVAKTPTQNPEMGPSPNSPPPSLGGQMLTRAHAGAGARSVPGLELGNEKFSTTSNQTASSKNSQQPASPAEETRGREKSNEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>D4D917</accession>
    <name>D4D917_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_03607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000184">
        <property type="protein sequence ID" value="EFE41665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022283.1">
        <property type="nucleotide sequence ID" value="XM_003022237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D917"/>
    <dbReference type="GeneID" id="9576886"/>
    <dbReference type="KEGG" id="tve:TRV_03607"/>
    <dbReference type="HOGENOM" id="CLU_371970_0_0_1"/>
    <dbReference type="OrthoDB" id="4174441at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="834" mass="87280" checksum="01F98957BB09B51D" modified="2010-05-18" version="1">MQPRSASRGSQYIRGTRPRDRQQQLQQLPPLHTKQHQQHPQDGYDGKRYYSPQQQQQQQQYQAYPGPASASPDVPEDEEPVYLPSIGNFQSLHSLVNNLPQFDTTNTTTTTTASPTSTAAASTSTNPWAESFSFPNGRPLASRTRHLNPVDRPFSVAVGGHPQQPQPQLQLQSQSAAASYAPAPRSTAARPMSTAAARNEPYRHAYSASSVPLAASASAASSSSSDAASIERQAYQAVSAVRRSPGSLLRKESYHAAYPAAGPAPVTTTSTAAVTSTATSASGSSSSSSSLTSVHQIPQPTRRPPPVPVQAPASTQIPSYHAYSGTSLAASNSSSSLDKQGQPTASSTSTTSTTSSTASTAAARPMSAAPGAPKTYHAYSANPSASASTSSLPQADTAASTRRTLPSAVRSHSYYGTGSPAAPPAAPPAAGVATNPMASSSTSSLDRQVRQSTAHRSASVAAARPRPTTSGSAAVARRATSNAAAMPRPASAVAVRSQSYNTPSGTPAASDMARRNTVVFDSDLTRNKNPQPNPPLIPLQQMQAAQAPASTSTASPSSAEQASKQPRFYALLRASMVVPDTVQIATVEEETTAIRQRSVYGPQPRPRSSRRSQWPRASSRLFTGSSMTDITDKDEADPQTDVVVESRASMSCPSLVPTSNLASASSTTLSTPKTSGEDYKSQYRKTKSFPLEEPSGTTTPTQSQVKASDSAAAPTPEAPPAPTSKPPAKPPSMSRTVTAPADIQQPQARKLIKRNPSAPKPRPNSRVAQTSRSMSLVGTPRLPTSGASSPPPLPRAMSVHIPSPATAQGQAADRSKKPRLTSLWSGLFRLRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4D949</accession>
    <name>D4D949_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000186">
        <property type="protein sequence ID" value="EFE41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022236.1">
        <property type="nucleotide sequence ID" value="XM_003022190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D949"/>
    <dbReference type="GeneID" id="9576838"/>
    <dbReference type="KEGG" id="tve:TRV_03639"/>
    <dbReference type="HOGENOM" id="CLU_045135_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="341" mass="34787" checksum="D8BC4AED4161CAAD" modified="2010-05-18" version="1">MAAAAAQHRGRDRDTSTTTTAAPPATSSTTSSTTSAAAAAATATNTTAMAAAAADRSKDRDRGDVGEAVSSETASSATTPAPAPAPYSTRSRNRPRINYAEDTELDAELEQPPAPVSASASAGAGAGATSNSTAKGTPGRKPKDRDAAAQTTSSSSSNTRIASPASNSERPPGMSTRRAAAAAASNGTAAARDKNSDSHGHAAAASTASTTTTTTTTASTSAIPGTSTFSANPNTVVVSSKKRKQPGSSTTVQNVVPANGGGHPNKRFIAAGSRNSEEAVTTSMMTFRSSRAMLRNGKLKADDGTLLAPNGNVYYVYFILIFFFFPSHLYIYYILSFSCMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9P9</accession>
    <name>D4D9P9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TRV_03842</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022025.1">
        <property type="nucleotide sequence ID" value="XM_003021979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9P9"/>
    <dbReference type="GeneID" id="9578909"/>
    <dbReference type="KEGG" id="tve:TRV_03842"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="279"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFE41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="474" mass="52070" checksum="E4C4CAF73168C627" modified="2010-05-18" version="1">MSAVKNIKRRKLSHTSSKPVSDDVSSGSERGQETPEESGEGPTDTKAPKTFKDLGIIDSLCDACTSLGYKTPTPIQAESIPLALQGRDLVGLAETGSGKTAAFALPILQALMEKPQPYFGLVLAPTRELAVQITEAFEALGSLISVRCAVIVGGMDMISQSISLGKKPHIIVATPGRLLDHLENTKGFSLRNLKYLVMDEADRLLDLDFGPVLDKILKVLPRERRTYLFSATLSSKVESLQRASLSNPLRVSISSNKYQTVSTLLQSYIFIPHKYKDIYLVHILNEFPGQTTIIFTRTVNETQRLSILLRALGFGAIPLHGQLSQSARLGALGKFRSGSRDILVATDVAARGLDIPAVDLVLNFDLPSDSKTYIHRVGRTARAGKSGRAISVVTQYEVEIWQRIEAALGKQLPEHKTEKEEVMVLSDRVGDAQRLAVTEMKDLHEKRGSKGATLRGRRKGDSKRGRDDMDREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9Q2</accession>
    <name>D4D9Q2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAIB/BAIF family enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_03845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000197">
        <property type="protein sequence ID" value="EFE41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022028.1">
        <property type="nucleotide sequence ID" value="XM_003021982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9Q2"/>
    <dbReference type="GeneID" id="9578912"/>
    <dbReference type="KEGG" id="tve:TRV_03845"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48626" checksum="0B434F39301696AD" modified="2010-05-18" version="1">MNSYRILRRVVNTDKLSRFANNKAFTAACKRYSTAAPSADTLPLAGIRVLDMTRVLAGPYCTQILGDLGAEVVKIEHPTRGDDTRAWGPPYAKYKDDTKEGPGESAYYLGVNRNKKSVGLSFAHESGIEILHKLAKESDVFVENYIPGSLKKYKMDYESLRAINPRLIYASVTGYGQTGPYSKRAGYDVMVEAEMGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNAIMAALIARGRTGKGQHIDACLSDCQIATLANLASSALISGEKDSGRWGTAHPSIVPYRSFKTKDGDILLGGGNDRLFGVLCDRLGHPEWKTDARFTTNALRVKNREIIDNLIEDLTEQRTTQEWLEVMEGSGMPYAAVNDIQGALNHSHVLARGMVQEVDHPDCGPIKLVNTPVKYSHATPGIRTPPPTLGQHTDEVLSNVMGYDKEKIAQLKADGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>D4D9S9</accession>
    <name>D4D9S9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_03872</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000198">
        <property type="protein sequence ID" value="EFE41393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003022011.1">
        <property type="nucleotide sequence ID" value="XM_003021965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D9S9"/>
    <dbReference type="GeneID" id="9578895"/>
    <dbReference type="KEGG" id="tve:TRV_03872"/>
    <dbReference type="HOGENOM" id="CLU_005361_2_1_1"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="116"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE41393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="806" mass="85282" checksum="35F36743D2291FAF" modified="2010-05-18" version="1">MLQEKLRVLVVGSGGREHAYAWKLSHSPSVEKVFCAPGNGGTDGGASSKMSNISVKGDDYQGLVVFAKENGVNLVVPGPEAPLVDGIQGYFQAVGIRCFGPSKAAARMEGSKAFSKDFMKRHNIPTARYGNFTDYKAACQYLDSVDHDVVIKASGLAAGKGVIIPQNKEEALKALKEIMVDHQFGDAGDEVVIEEYLEGDELSILTFSDGYTIRSLPPAQDHKRVFDGDQGPNTGGMGCYAPTRIASKAVIEAIDRTIVLPTIDGMRKEGTPFVGILFTGLMMTKSGPKVLEYNVRGGDPETQTLLPLLSDDTDLAEVMVACTEHWLDGVTLKVESKSSATVIAVAEGYPGSYAKGRDITFDKTADSTLIFHAGTTLADGKLKTSGGRVIAATATADTLEEAVKASYSGISTIHFDGMHYRKDIAHRAFKTSSKTSNTQESLTYASAGVSIDAGNELVNQIKANVARTRRPGSDAIIGGFGGAFSLSSCKSGFHEFSPTLIGAIDGVGTKLKIAHEMGIHNTVGIDLVAMNVNDLVVQGAEPLMFLDCYSCGKLEVEVAAAFVAGVADGCVESGCALVGGETAEMPGLFTDNSYDAAGAAIGAIDTSKNRLLPDTEGMKPGDVLLGIGSSGPHSNGFSLIRKIVEKSGLSYHDPAPFKMGKECANLGTALLTPTRIYVKQLLATITKFPQGAVKGMAHITGGGLAENIPRVLPKNLQADIDISSWPLPDVFKWLKKTGNVTGSEMARAFNNGIGMVVVVDESQSAGIKKYLEELNETVYVIGKLAAKADGDDKGCVLRNMQTWDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DA61</accession>
    <name>D4DA61_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000205">
        <property type="protein sequence ID" value="EFE41212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021830.1">
        <property type="nucleotide sequence ID" value="XM_003021784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DA61"/>
    <dbReference type="GeneID" id="9578710"/>
    <dbReference type="KEGG" id="tve:TRV_04005"/>
    <dbReference type="HOGENOM" id="CLU_606867_0_0_1"/>
    <dbReference type="OrthoDB" id="4174318at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="319"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE41212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="484" mass="55650" checksum="ED0ED1D99D725691" modified="2010-05-18" version="1">MAEPPAKDGLETPNILKKLKAERNQHSYRDLLSKWEIPINESEADIAKYFVSKIFEGMAKNVSLQHAGKARGSSFEQNYLNSQRCVQVQALVDMLLPISSGSMENDPSISTPLKDRYESHPIPWCYCSDPWDHGTLLMRNRWYNLYEGIPDLEYMLMLVQADHFREMLWYLEPRRWDYMVASLHQYRTSIKVFAEVIHLDFRWPFIARARQLPMELAYGYFKGKRLSDYHPHTIVVNDSKEEIYGVAAGFRHTEFYKILHSLASVDRALSNEANKNPPPFCKINYNITDERACISCLKRKHLCLCEYSGGKDELFFRSSFLQLMDCNDGRGTGVRSLIRVSEGVNLGTLRGKLRDPDPIGCPLTLISGEMRGVITKVNKHDSGNWTRFLNHSCDPNSSVIFGIYQGIPTATIVTTKCIQPMQEVTIDYGKKYIDTLFWICLCKSSTCRYSNDDDEDEEDDPSLFSLTKGSPIEYHCEKERVSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAE3</accession>
    <name>D4DAE3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021759.1">
        <property type="nucleotide sequence ID" value="XM_003021713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAE3"/>
    <dbReference type="GeneID" id="9578639"/>
    <dbReference type="KEGG" id="tve:TRV_04090"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE41141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="465" mass="52146" checksum="DE4321DDD3365D90" modified="2010-05-18" version="1">MSGLTFEIAATAVLDPACIFAPSSTEDVSRAVMLFSQNGCKFSIKGGGHSNIPGAASIDDGVMMVMSQMKTAEIHPEEGYIHVGAGVLLKDIYSTLDPHNLSAVIGRYGEIGLGLAVGAGISYFSNRDGLAVDNMRNYEVVLADGKVVNANLRENKDLFWALKGGNNNFGVVTHFDFNTVATPGSTYGGLIHYPESSLDKVDDLVYDYHTRQAVEGLFTHAMPQWVYNGSTNDTYNLTPVIYNDNVEELPPIMKPWLDVPHTSSTLAPRTYENLSIYLNEGFGDGLIQEQRVFTVYADKKFYKDVLYKFREWLQNFQDVPGFLGAHLNMPITPRQVHQGRLKGGNALGLEGAANRTLGVLFFGITFEDPQYKEHILPEHDRFVQSMIELARERGVLYPYMYAPSYLTPNPAYWLYPPYHIYPGPVPDSYYMMHGTWQKFANIRLSAQYAHILWLQPSCHRQLWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAH9</accession>
    <name>D4DAH9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyroglutamyl peptidase type I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_04126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000208">
        <property type="protein sequence ID" value="EFE41177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021795.1">
        <property type="nucleotide sequence ID" value="XM_003021749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAH9"/>
    <dbReference type="GeneID" id="9578675"/>
    <dbReference type="KEGG" id="tve:TRV_04126"/>
    <dbReference type="HOGENOM" id="CLU_043960_0_0_1"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE41177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="264" mass="29443" checksum="F1AC9104930E3628" modified="2010-05-18" version="1">MGDFGATSSLDEPVSLPGQPLPPQDDDIHVLVTGFGPFKTHPLNPSWLINSLLPQYATTSKNRRVHIHAHPRPIRVAYAAVREEIPRIIEEFRVAHDGRPPHLVIHIGMAATRQYYAVETVAHREGYKHTDVDGQFGIPFDPSLPERLQPGVPTPADYASTSESTDKVRVIPSPLDTGFLQTWRKSLPAGRSIDVRLSHDAGHYLCEYIYYTSLSMAWEENRPRAALFLHVPGWTDKASVEMGVEVVVGLVRAMVESWIVETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAM3</accession>
    <name>D4DAM3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021713.1">
        <property type="nucleotide sequence ID" value="XM_003021667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAM3"/>
    <dbReference type="GeneID" id="9576796"/>
    <dbReference type="KEGG" id="tve:TRV_04171"/>
    <dbReference type="HOGENOM" id="CLU_031138_1_0_1"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="310"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE41095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45666" checksum="0DFCA60044128831" modified="2010-05-18" version="1">MKIQTERLSKVSSLYTPTITVGIDELTKDAEPAVRKPASKSKRKSKLNLSFGVGGTSMTDDVSDEGEVVIPKKTGIRRNVLDRASNRKHLNSSETLPVRVGRDDDRPSYSKDYLQELRNSTPSTPKNVSRPDTEDEKDKALDIAGKFGEVAKYTRPSAIPSEAEIREKKERRSRLAKEQEYISLNDTGIEEDEDEWSLSKKPLETDTRLVRDDEDFAEGFDEYVEDGRIAMGKRAEIEQKRRQRANMKELINDAEDLSDEDDSETERRAAYESAQTRAGMDGLKRDADEPVTRPKTPPKITSLPTLASKLAGLRMNVVEMENNKTQLVNRLEELRKEKVEISERETEIQNLLKEAGEKYEKLRAEAGQTATTEKLITGNEVGADRGLDNLATMSLPAPDTEMDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAN2</accession>
    <name>D4DAN2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_04180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000213">
        <property type="protein sequence ID" value="EFE41104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021722.1">
        <property type="nucleotide sequence ID" value="XM_003021676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAN2"/>
    <dbReference type="GeneID" id="9576805"/>
    <dbReference type="KEGG" id="tve:TRV_04180"/>
    <dbReference type="HOGENOM" id="CLU_2063187_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE41104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="119" mass="13474" checksum="253585835887ED47" modified="2010-05-18" version="1">MARLVFSHALTVHKLVLHQAPSIKHPTVEETKKRREDALLLLLPSLRCRRPAGAAPKTSQKPSSLILFFSSSFLSSSYYYPFVFISRLYPRLQIHCREAPVYSETSLSVTCHSTSSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DAU1</accession>
    <name>D4DAU1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_04239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000215">
        <property type="protein sequence ID" value="EFE41041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021659.1">
        <property type="nucleotide sequence ID" value="XM_003021613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DAU1"/>
    <dbReference type="GeneID" id="9578620"/>
    <dbReference type="KEGG" id="tve:TRV_04239"/>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007361134" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE41041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="643" mass="71967" checksum="FBF98C7C6386C526" modified="2010-05-18" version="1">MWPQSKSHLLLSLFSPILSSAFYLPGVAPTSYDVGQKVPLHVNHLTPTVAQDAQVHSVFSYDYYHPSFHFCKPKDGPKDVRESLGSIIFGDRILTSPFELHMAKNESCKLLCPEVKFDGLSSQFVNHRIWQGYNINWLIDGLPAAQINTDDQTNEQFYSPGFLLGDINSDGQSFLYNHYDIDIEYHRVAGLGTKEKYRVVGVLVHPSSRKTKVSGGKADCSGKDIVLLDGTADTSVAWTYSVTWRESSTAWATRWDKYLHVYDPSVHWYWLIYSAVFVILLVTLVSSILLRALRKDIARYNRLSMINMDDFNDNGDSVEEGIQEDSGWKLVHGDVFRTPNYPLLLSLLVGNGAQLFVMTGITVVFALFGLLSPSNRGFLGTVILILYTLLGFVGGYVAARTYKSFGGESWKRLIILTPILVPAIAFSTFFLLNLFVWAKGSSGAVPFTTMLLTVIIWFVISVPLSVAGSWIGLKLPGFEGPTRTNQIPRQIPPAVWSLRPLPSTLITGMLPFATIFVELYFIMTSLWTNKIYYMFGFLFLCYGLMIMTSATTTILLVYFLLCAEDYRWHWRAFIGAGMTGGYVFLNALIFWATRVSFGGVTGAVLYLGYSALLAFLVFVLTGTIGLFASWAFVHRIYGSIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DB61</accession>
    <name>D4DB61_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000220">
        <property type="protein sequence ID" value="EFE40895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021513.1">
        <property type="nucleotide sequence ID" value="XM_003021467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DB61"/>
    <dbReference type="GeneID" id="9578461"/>
    <dbReference type="KEGG" id="tve:TRV_04360"/>
    <dbReference type="HOGENOM" id="CLU_026441_0_0_1"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="672" mass="75047" checksum="49604855E9B99B6E" modified="2010-05-18" version="1">MTLTHIHPEDDAPPPYTPTDPLTPASTINDAASQVSTENIPSYTHAVEAPNFVSAVPYFSERGLPSTARSDGAILEHTLVFYRRSQAKDFSKYPRCWRSRTEEITQHDWDTFLNYLLPPHLGPASNHPQLPQKLRAEIERDRKDRPQETEEERQWRITAVVTEWNVNFFQPRGVVIVYCFVREDGGQPESPLCPSCYPNTTSSRSRNDICRSLFEEPTDNTSREVHELPQLPNAVPSGRQNQQTTDAASPPAAAAGSGGSSGNQYQYRSSPAGGPGVWVFNPGAAVNNIASMISDQVQRYSQYVSEQAMEHSRMVSEQVQAASREVERNAHAHAFYVQQQAMDARNRAIHNFTTYRDQAQSSWGGHHGPHGRFGGHFHHHHGRWAGRGYGGPGRGRNTWGPEGCQPGSSGWGFWQRGADPAGRRGREWGHVEQKGRRARSASVSSSSSSSSSSSSSSSESLDSASPDSDLKKGELAALKTALQNLKQQQEQRQLSTADYRARRKELRRDCKALKSARRDFHSAGRRCRDTTSGGCSGSSSRAAGHPSTTRGEFSSDIDEIKRDMQEIKDHYVNLIRSLQGEKRELKQAAKNLKQEEKQARKEEKQARKQEKAARKEERKRAKEKGKGKAKETEPDIPLERRMEDMNISSNIPPPEYPQTPQAAGTVMKDVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBC8</accession>
    <name>D4DBC8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_04427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000222">
        <property type="protein sequence ID" value="EFE40836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021454.1">
        <property type="nucleotide sequence ID" value="XM_003021408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBC8"/>
    <dbReference type="GeneID" id="9578415"/>
    <dbReference type="KEGG" id="tve:TRV_04427"/>
    <dbReference type="HOGENOM" id="CLU_007426_0_2_1"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="252"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE40836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="760" mass="86021" checksum="50C4A803BDC55487" modified="2010-05-18" version="1">MSSPDDMQNRIDRLENLVLSLMTNGAQSAGPTAAIATVSGDSSIASQGPQSASTNTVDIDLKDEESDTEQVTKSFGIMKVDNQSQKSYYVSEAHWSTILNDISEVKHFWATHKKQYEEQMQKVQATKQTQDLKGSALIFGAMSLPTEAEIMASFPSKYTADMLLRRFFATLDPSITMVFAMLRLAMLSYHRERDEPPEFRGKSLDIAKTYRIAMAQGLVYSDFTKPHRYLLETLAFHLQAEYSQSCDSETSVWILVGMIVRLGMRMGYHRDSKMFPNISVFQGEMRRRLWTWVRQADLLFSFEAGLPSMIRTGDADTDFPRCLYDEDFDEDSKETPPERPFNQPAPIAYTIVHARLTTVFSRVLEKSQKLRGSSYEEVLELDRELRHAREMIPEWLQMKPLPECAHEPSTLIMNRIAVCTYPIGQLPNLVLLSLILQVESIYHKAQCVLHRPYLTRARENPRYTLSHRACIDSSLELLRLQAMLHAEKTSGRRVLHPRYYTTSLTGHDFLLASTILALDLYHEAQLEANRRQGDSPYGWGCGMQEEMLATLRQSYNIWNELKDESMDAWKASSVLGLLLEKISCRRENRDTTSMDSSFDPQDEKQSAAMTLGLLSSGLTPQGPTSPPQFGDSMIGIDRTSSAQQGGLPSNIDQLAGLNSPFGMFGQMPDMQPFNLDWEAWDNYIQSAALDPTNQNWTDVNQRQDFQQTHQPQTTAENEPNMSIRPPTYPLHNGTYDANGNASTHPTYMNNNDYQGGANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBG3</accession>
    <name>D4DBG3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_04463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021389.1">
        <property type="nucleotide sequence ID" value="XM_003021343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBG3"/>
    <dbReference type="GeneID" id="9578268"/>
    <dbReference type="KEGG" id="tve:TRV_04463"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE40771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15850" checksum="E0369C99F3EE20CB" modified="2010-05-18" version="1">MASTPSVQCFGKKKTATAVAHCKQGKGLIKVNGQPLALVKPELLKFKVYEPILIVGLDKFAGVDIRVRVTGGGHTSQIYAIRQAIAKSIVAYYQKFVDEHSKNQLKQALVQYDRTLLVADNRRCEPKVFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBJ9</accession>
    <name>D4DBJ9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TRV_04499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000226">
        <property type="protein sequence ID" value="EFE40807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021425.1">
        <property type="nucleotide sequence ID" value="XM_003021379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBJ9"/>
    <dbReference type="GeneID" id="9578385"/>
    <dbReference type="KEGG" id="tve:TRV_04499"/>
    <dbReference type="HOGENOM" id="CLU_016578_0_0_1"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFE40807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68905" checksum="3111870E73AB5AB8" modified="2010-05-18" version="1">MADTDDKDRAEKLAAAKKRVAQMQKQKGKKGKKGESSKQAAASAEAGDKGPSPDSKPEEPDTEKQAETETPKDAEKDNTEEAVTETPVTTEDQVDESNNKEDKGGESLPKTRSHGRQPSISVQSKLRSSSFRQDSKVPVVSPGSSGVKSPTLPLSPDGSTAPEVFRKQAIRLEELEKENKRLEKEVEATNAKWKKSEEELDDLRESSAETVELKEKLAKAEKQAEEVESLVGSKPSNSAAVSGSPDSPSELQSQLDAKSATIENMEMEISNLRAQLNSQSTSSSAHQEQISALEEKLSRSESALEKTQRELADAKQAVSRAAEKAVKEGVDKTSTETLIKSLERQIKETEEAKAEADKKADLLEKKLQALSNLHKESESRHQTRMKERDKFEKDVAMLTKKITTTENENLRLKEERDRLKKREASGVGADEGLDELEDEERQRLERKVRDLEGEIFDLRRGIWKERKRELSSQNDGEGPSADRKSFSGTFDDVDLTGGAPGGHSYAGRRSISHRPQQHSSFATVLQSGIAAFTGAQDHDRGHKSFDYGSHTDPNEEFLDDDAFDEDAFARAQEEEEAKKRVEWAREIKAKLKNWKGWRLDLVECRYGAQGVGIGLGEIFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DBS4</accession>
    <name>D4DBS4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_04575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000230">
        <property type="protein sequence ID" value="EFE40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021313.1">
        <property type="nucleotide sequence ID" value="XM_003021267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DBS4"/>
    <dbReference type="GeneID" id="9578162"/>
    <dbReference type="KEGG" id="tve:TRV_04575"/>
    <dbReference type="HOGENOM" id="CLU_1526273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="176" mass="19471" checksum="31914EC361BE0E81" modified="2010-05-18" version="1">MITRNSGSYQVESERLQGEDVGRPQELGVGQGLLGRPGETAEKGGPGLAQQPQTGLLVGRGHRRRVDGEEQGLGAAGDAGQVRGRVEHHPLHRLRVEELDYRVDVVQVDLPQLEELRRRRVKPMEVEVAGVAKQAQGLALLLLEVELRLLVCVQNLRILQLFPLDSSHISMLHFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCC5</accession>
    <name>D4DCC5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021105.1">
        <property type="nucleotide sequence ID" value="XM_003021059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCC5"/>
    <dbReference type="GeneID" id="9577947"/>
    <dbReference type="KEGG" id="tve:TRV_04778"/>
    <dbReference type="HOGENOM" id="CLU_051063_0_0_1"/>
    <dbReference type="OrthoDB" id="4171673at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="52032" checksum="EB01214227B454F5" modified="2010-05-18" version="1">MDPKLTDDEKSRVKDLRAAVRRARQGSSEEVYGSEDYWKYSKEELDGEDKISDLRFRALQRNSDLSDPSFEQAAQEYKSQQEQRSAKRLSILEKEKLFDKRNKILQQSSSTTTNLTSMRAAYVDLLLTIQSKTSRQKQSDFSKDVLRAYGGTTKTNNTTYCFSVLDGTRRERDEFVAAHIFPLSIGPKAMEYIFGRDARYEINSPRNALLLPKKIEKHFDAHQIVVVPAKSDNPDVREWQFLIVDKSGLWNEYVFPGGEMKFSDLHERKLIFPNDFRPRARYLYFHYLTSMIIHFRAAQKTGIVRSELPDAEWPELTRAWATHGEYLRDNMIYGFMEELGHDLPEDLKQNALTHCAPIRSNSEAEELEEVIDSLGMIQIGSDDDDDDDDDDDDDDDGEDGNFDEDDEEGEAGACKKRRDRKDSKKGINFTSTSGDVALDPLLLLHWRSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCD5</accession>
    <name>D4DCD5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000243">
        <property type="protein sequence ID" value="EFE40497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003021115.1">
        <property type="nucleotide sequence ID" value="XM_003021069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCD5"/>
    <dbReference type="GeneID" id="9577957"/>
    <dbReference type="KEGG" id="tve:TRV_04788"/>
    <dbReference type="HOGENOM" id="CLU_146833_2_1_1"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="111" mass="12076" checksum="6C062D326DD8CC72" modified="2010-05-18" version="1">MASDPNSSKDPVLKAVYQAPRTSQETAEPSAHTFAQQLSSSIPPPGENSTAERTKYLAELRGSIVSLQADVNAFLTEKMEEDKLRDAQGAGTIDDKTEEDNYGEEVVDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCJ4</accession>
    <name>D4DCJ4_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_04849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000248">
        <property type="protein sequence ID" value="EFE40366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020984.1">
        <property type="nucleotide sequence ID" value="XM_003020938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCJ4"/>
    <dbReference type="GeneID" id="9577836"/>
    <dbReference type="KEGG" id="tve:TRV_04849"/>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE40366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="451" mass="49861" checksum="3CCB58BD6BCF871E" modified="2010-05-18" version="1">MNVNKKLGRLKQWAGERMGGEIKTNVSDDFKLLEMEMNLRQEGMERLNKAMAAYVRAISKRSEGEDKEKLFPIGNLGGVMVAHGEDFASNSEIQEQYVAAATSSWLESLERSLNQLKEYQATRKKLENRRLAYDTSQAKMQKAKKEDFRVEEELRSQKVKYEEATEEVLRRMMDIKESEPECTADMSAFLDAQLNYHEKCREVLLQLKDEWPAGYVSTSSFFSCTILFFTVLTNYTRPTQQFNSYGRRSTLTRSNTSFNDQMAGEDTYQSSSQQPGTSRSREPSRPGLGGRQPTFEGPTQLRTRRPSPSPAPALRTPLRTASDSISPATIGSSAAGIANARSQLRVISQGYNGGNNNNNNSNTHNDGYYDSTTDDGASPVRNSPDQYYSSTSTSPLRTVPASGQVPTPASGSGSGTATPVKKPPPPPPPSRSKKPPPPPPPPKRSVSAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCU2</accession>
    <name>D4DCU2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_04947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="ACYE01000251">
        <property type="protein sequence ID" value="EFE40335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020953.1">
        <property type="nucleotide sequence ID" value="XM_003020907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCU2"/>
    <dbReference type="GeneID" id="9577805"/>
    <dbReference type="KEGG" id="tve:TRV_04947"/>
    <dbReference type="HOGENOM" id="CLU_051197_0_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE40335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="374" mass="40643" checksum="75288366691F49BA" modified="2010-05-18" version="1">MAAFLHFHESEFTRETRAAHIGQKGFTVWFTGVSGSGKSTIAVALEKELITKRKLNTYRLDGDNIRSGLNKGLGFTEADRTENIRRIGEVAKLFSDSGMVTLTSFISPFAADRAAARKLHELSDAEKERGETPLPFIEVYVYVPENLVERRDKKGLAVLASKGLQKGVTAVGKKGDARYEEPKSPEIRIDNDENMTIDRAVKQVIDYLEEKGLLTSPPDIETAEAESAKRVKEGQEIKEKRLLRELDERDAALKAAKASGDNKEIIDAYDRATKAAGALKAFYTTKHRVTAEAAEAGKLAEDMQSEIAKLAEQVATYTAGTEARAVAGKIYKAKVEADDAEARAKAAATEAATKAEALAEAEAAMAESDSTVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>D4DCV5</accession>
    <name>D4DCV5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_04960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000252">
        <property type="protein sequence ID" value="EFE40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020938.1">
        <property type="nucleotide sequence ID" value="XM_003020892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DCV5"/>
    <dbReference type="GeneID" id="9577769"/>
    <dbReference type="KEGG" id="tve:TRV_04960"/>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="677"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="817"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="952" mass="106036" checksum="7BC45DBB5FECC859" modified="2010-05-18" version="1">MASYLDHSYTLVHQDNSADQPTVQELKTQLEKGTDETKMETMRIILIMMLNGDPMPQLLMHIIRFVMPSKSKPLKKLLYFYYEICPKLDANGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREPELLEPLLSSARQCLRYRHAYVRKNAVWAIASIFQHSESLIPDAADLLLAFLETETDPTCKRNAFAALVTISHESALVYLSSTFDGVANADELLQLVELEFIRKDAVQNTQNKARYLRLIFDLLDANTSTVVYEAATSLTALTSNPVAVKAAAAKLIELCIKEADNNVKLIVLERVHQLMKRNEGVLDDPTMEILRVLSSPDIDVRRKALFIALEMVSSRNVEEIVLLLKKELAKTVDEQYEKNNEYRQLLIQSIHQCAIKFSEIAASVVDLLMDFIADFNNNSAVDVITFVKEVVEKFPKLRPSIVERLVSTLDEVRAGKVYRGVLWVVGEYSLEANDIREAWKRIRASLGEIPILASEQRLLDEGPDAGAAGQDSVNGHAKSTTGPKVLADGTYAQESALTSESAAAAKLAAVKAAQKPPLRQLILDGDYYLATVLSSTLTKLVMRHSELSQDVARTNALRAEAMLIMISIIRVGQSQFAKASIDEDSVDRIMSCVRSLAESAQRKELESIFLEDTRQAFRAMVQVDEKKRAAKEAVEKAKTAVQVDDAIPIRQLAKKSEEGAEEIELDLAKATGGDSTLEDLTSKLSRVVQLTGYSDAVYAEAYVKVHQFDIVLDVLLVNQTTETLQNLSVEFATLGDLKVVERPTTQNLGPHDFLNVQATIKVSSTDTGVIFGNVIYDGSNSTETHVVILNDIKADIMDYIQPAHCTETQFRTMWTEFEWENKVNIHSKAKSLRAFLQQLMDRTNMSCLTPEASLEGDCQFLSANLYARSVFGEDALANLSIEKEGDDGPITGFMRIRSRSQGLALSLGSLKGIKANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD67</accession>
    <name>D4DD67_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_05074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000257">
        <property type="protein sequence ID" value="EFE40230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020848.1">
        <property type="nucleotide sequence ID" value="XM_003020802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD67"/>
    <dbReference type="GeneID" id="9577587"/>
    <dbReference type="KEGG" id="tve:TRV_05074"/>
    <dbReference type="HOGENOM" id="CLU_055305_0_0_1"/>
    <dbReference type="OrthoDB" id="4179317at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058251">
        <property type="entry name" value="zf_Tbcl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058252">
        <property type="entry name" value="zf_Tbcl_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26647">
        <property type="entry name" value="zf_Tbcl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26648">
        <property type="entry name" value="zf_Tbcl_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Probable treble clef zinc finger" evidence="2">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Probable treble clef zinc finger fungi" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE40230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36707" checksum="91A527016D4364F4" modified="2010-05-18" version="1">MPRSSSSRTDRGHKGKKSLGATPREKKIPPPCEALTHSFVPCKNRANTKASRKIPVCWAHRKQGETVTRCQAVLENNRKCLKKIPWSERRQVCTKHADSPLPCFIIRLPIELRQQIFSYILDEYQKEYVPLYTYFSILHMARVNRQIYQDACDLLHRKLVCNISLRNENISILKKVCLSVRPGSWQRFKQFHFQFYDEMQEATINNLTLIVALLRDTCMKLSVDPSYTIWWHSHYGLERAIDALPSYLDIFRQLRGVREARVEMSPNLTTALSVYGWNSLNPEAGMAIKSKWESYYKQWVKDLERGHSAERDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DD90</accession>
    <name>D4DD90_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_05098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="ACYE01000259">
        <property type="protein sequence ID" value="EFE40172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020790.1">
        <property type="nucleotide sequence ID" value="XM_003020744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DD90"/>
    <dbReference type="GeneID" id="9577541"/>
    <dbReference type="KEGG" id="tve:TRV_05098"/>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="11">
        <location>
            <begin position="40"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE40172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="418" mass="47017" checksum="268C9DD3BADC6E64" modified="2010-05-18" version="1">MAWRASERLMETIRHYASFPATGVSLRQMVQFGDKPSTGDLPDGLNEMPSIKKVQDWYAQSFEEITKLERPKLTEEVRSRLLNSSRMNGREPRMLEQATPNPSIKQGQYRSSPTTSILNSIYSNGNSSVIGNNGSTTTTTTATNGAKHRVAGTRRYFVAADDGADWPPELIDYNARLASTLDTIKRRHDSVVTTVAQGVLEWKRKKQRLQIDSGIQAFLDRFYMSRIGIRMLIGQHIALTNQHHTFHPNYVGIICTKTNVRQLAQEAIDNARFVCEDHYGLFEAPKVQLVCRDDLDFMYVPGHLSHMLFETIKNSLRAVVETHGPENDSFPVTKVIVAEGREDITIKISDEGGGIPRSAIPLVWTYMYTTVDQTPNLDPDFNKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDB2</accession>
    <name>D4DDB2_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000260">
        <property type="protein sequence ID" value="EFE40168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020786.1">
        <property type="nucleotide sequence ID" value="XM_003020740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDB2"/>
    <dbReference type="GeneID" id="9577537"/>
    <dbReference type="KEGG" id="tve:TRV_05120"/>
    <dbReference type="HOGENOM" id="CLU_2198903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE40168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="108" mass="12115" checksum="AA64A20094F72D2B" modified="2010-05-18" version="1">MSREKLLLAGLHAWRRIGRLRSYSCHCHAAPHRGQPWLGLYPLLLLLLLLLLLFVSLASYHRLLYSAPPKYLPLCPVHANTGALGRRLPIALQAVLGKKLTGCLKMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>D4DDZ8</accession>
    <name>D4DDZ8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_05362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000281">
        <property type="protein sequence ID" value="EFE39915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020533.1">
        <property type="nucleotide sequence ID" value="XM_003020487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DDZ8"/>
    <dbReference type="GeneID" id="9584273"/>
    <dbReference type="KEGG" id="tve:TRV_05362"/>
    <dbReference type="HOGENOM" id="CLU_047036_3_1_1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="134"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="303" mass="35895" checksum="B193387A2F69CB6F" modified="2010-05-18" version="1">MDVALDLLDPLVLDKAYAYFVPAEGTASSQPVSAWPRDSILRQCISILVITQLGASLLYWIFSSFSYYFIFDRRLEYHPRFLKNQVRQEIVSSMMAIPWINIFTLPFFLAEVRGKSLLYTRVEDYGWAWMGVSVVLFMIWNDFLIYWIHRLEHHPSVYKYIHKPHHKWIMPTPWAALAFHPLDGYVQSLPYHVFVFVCPVQKYLYMTMFILVQIWTIFIHDGDMISGHWLEKYINSPAHHTLHHLYFTVNYGQYFTWADSYFDSHRAPRPELDPLHDALRVMREKGLVDEKGNPIPAKDKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>D4DE78</accession>
    <name>D4DE78_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_05445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000286">
        <property type="protein sequence ID" value="EFE39860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020478.1">
        <property type="nucleotide sequence ID" value="XM_003020432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DE78"/>
    <dbReference type="GeneID" id="9584217"/>
    <dbReference type="KEGG" id="tve:TRV_05445"/>
    <dbReference type="HOGENOM" id="CLU_054409_0_0_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="134"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE39860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="365" mass="40054" checksum="B0A77FEC31DE609D" modified="2010-05-18" version="1">MTGSAALRYLALDTLATDCVALFRESCFKAQRPVVLPRGLFRNYRAVSRWFDPPPSPHPPPPPGAASSAPASNPGLNYAYLEQHGDCYVPLELTIPGGRDGIVFERAHRPLSLFLQWTRSVQSTPAAEAQDGPRLYLAQCQLLDLPGSLREDFPTPSYVMQAGKGDIYDTNIWVGLAPTYTPLHRDPNPNLFVQLAGSKHVRLLAPDVGRGVFAQVRETLDSARTGHGCSSAIRGDEMMKGAERQLLDHAVWDNNNNEHTSGTTQENVGYDAILQPGDALFIPTGWWHSIKGVGQGITASVSIPKTHAISTETNNNYLTSNRSTGGSGEPKRNKIKIKSNFHYAIGDKNMHCINWVYSLYKYTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DEU3</accession>
    <name>D4DEU3_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_05683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000311">
        <property type="protein sequence ID" value="EFE39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020244.1">
        <property type="nucleotide sequence ID" value="XM_003020198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DEU3"/>
    <dbReference type="GeneID" id="9582785"/>
    <dbReference type="KEGG" id="tve:TRV_05683"/>
    <dbReference type="HOGENOM" id="CLU_2335160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF41">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="98" mass="11018" checksum="580DBF99F55140A4" modified="2010-05-18" version="1">MAQTKDITLLHFNDVVARFASILANPRYLTRDVSAPDYQLRLFSGDAFSPSLEASVLRGEHIPTILNTMNIDVACYGNHDFDFGEDRLVELSKVTKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF38</accession>
    <name>D4DF38_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_05783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000330">
        <property type="protein sequence ID" value="EFE39524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020142.1">
        <property type="nucleotide sequence ID" value="XM_003020096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF38"/>
    <dbReference type="GeneID" id="9583912"/>
    <dbReference type="KEGG" id="tve:TRV_05783"/>
    <dbReference type="HOGENOM" id="CLU_044727_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="246"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="246"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="481" mass="53134" checksum="665F55A344EBCC0E" modified="2010-05-18" version="1">MDDDTSILCPSICTQMHHSNSHPFTTPQGSEISQSQCAPGSAATSLHQHRRVISHPSILQQMLDPSLFGDPLQQQQQFSSMTHSHGSWGSAMEPNTFCSTDAMAYDIVENKGNILSWEGETPGPTELELDLFAATYPLFDEFRELERLGYQTSGRPNTSTTSQRNCSQIFDNQYPNSVSTGSRPSFDSSTSRPESAIYPPLSPENSVGSSSPVDFHVLYGSDSLVRSVPEAVNLASEDETDDDSVSSEEPYARLIWRALMSAPGHKMVLKEIYEWFEKNTSKAKNSDSKGWQNSIRHNLSMNAAFEGVKEVLSPGAQTRKSGNAWVLTERAIRHGVQSTTRYRKPGVHKKSQKSDHPAPQRQKSGARGGRAAKKAAKYRRAIQESQRLDRNSQNAPPSDIPFNQHDILAQTASCVEYGPAEPVNDYVLSDYGLENLLGCNELIPRSPLFYPDLDLDENQQPSGTTVLGGQPIGRDFNPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF46</accession>
    <name>D4DF46_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000330">
        <property type="protein sequence ID" value="EFE39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003020150.1">
        <property type="nucleotide sequence ID" value="XM_003020104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF46"/>
    <dbReference type="GeneID" id="9583916"/>
    <dbReference type="KEGG" id="tve:TRV_05791"/>
    <dbReference type="HOGENOM" id="CLU_3335443_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="38" mass="3298" checksum="CAC04FF5B12EF600" modified="2010-05-18" version="1">MPGGAAGAAGAAGVVDGGSGAGDAVVAEIGIAKYGHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4DF64</accession>
    <name>D4DF64_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_05809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000334">
        <property type="protein sequence ID" value="EFE39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025843.1">
        <property type="nucleotide sequence ID" value="XM_003025797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DF64"/>
    <dbReference type="GeneID" id="9583903"/>
    <dbReference type="KEGG" id="tve:TRV_05809"/>
    <dbReference type="HOGENOM" id="CLU_369263_0_0_1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="797" mass="87207" checksum="84724397A1BD9516" modified="2010-05-18" version="1">MASCVVKEYGSQLSTGSSDNSVQENVDTTANGKDEYQPAEASSVVATTASVASHQDAQQMSEQSVTIAEVVEPEDAPADPTVDAQVSGSESSPTPVENFSLARTSLACFFGPTPHSTQKQKFQPPSRLSSSSPLSTCSLPVAPPPSPASVCGRQYAAAAESPYPQLSVLPNPPSFLPQMYPGSQFQGQYPNGNANSNSVSRGMPPAMAAMPSTAPGNVQYPQQGNFQRSIRPVPPLKFRRYLRPTWRIAYAFHPQVPIASAPGPFTSACSSSVPAPVSKAPPMPIAPVSSPVKPKKSEYKGPLIVSSYPVRPPSQNQSSQQPFQHSAQQSAQQHVPQHVHYPVHRSAQHTAQQHGQHSAHWLVHQAAQQQRPSHSQVVMNNPGHAYGIYNNMTTNGHNPRNNNNVAVAHYHNPQYPQAPVPGPYHSSFPGNGLSNAHGFHNMNNNTPTALPQAARPSPIEDPFETGTGPQPVPAGAVLKISNIPYNLLAREVTHFLGRRAKLLPESRGTSIHVIMERSTAKTMDCYVELLTQTDAEEALSWVNRNLPAHSPRLGDRHVHVEMSSQDALLREIFPRAKCVLWKNGIPEIQPNTDRYSTGFQGFLTNEELFCMVHFAEAPKRFPWDSKSLYTVEHRNVLFDATRRQLQALLQQVNARRVIQLDERLLRDLLNAGLRCSTFNERQKYLLRVAAGQALGPVPRTVVFWPFDALTRRANAREESVEEYARLIRAAVLRRVPNLGELNNSWDAIQHGNSPFGPLMLEWRGEGARRSLQAAINTEIGVMKALVSEGLAAVNTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFW9</accession>
    <name>D4DFW9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TRV_06072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019874.1">
        <property type="nucleotide sequence ID" value="XM_003019828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFW9"/>
    <dbReference type="GeneID" id="9584625"/>
    <dbReference type="KEGG" id="tve:TRV_06072"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFE39250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="353" mass="40191" checksum="C86FB977B1725D59" modified="2010-05-18" version="1">MSDKALSAQQEIITGYVGQLIEELRARSIGEKGGKKGMVDMVRWFNFTSFDILGDLAFGEPFGCLRSGIMHPCIELIFTAIKSVMDMQIIRRVPGLFPMMMAIAGLFQQSQHLQDQFMFCQKKARERLGRETTRPDFTLTVTYILRATEEKGMTQDEIEANAQILIMAGSETTASALSVMQKLRKEIESTFQHESDITMRSTQGLEYLNAVLQESMRVYPPVPCTFPRTTPPGGATVCGQYVPGGYIVGINQLAAMTSAKNFTDPTKFVPERWLGDERYKNDCKKAYQPFSYGPRNCLGKNLAYAEMRLVLTRLLWNFELELSEESKDWHSRQKVWMMWDKGDLNVKIRPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DFY6</accession>
    <name>D4DFY6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000344">
        <property type="protein sequence ID" value="EFE39267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019891.1">
        <property type="nucleotide sequence ID" value="XM_003019845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DFY6"/>
    <dbReference type="GeneID" id="9584642"/>
    <dbReference type="KEGG" id="tve:TRV_06089"/>
    <dbReference type="HOGENOM" id="CLU_023111_0_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE39267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48305" checksum="473DD07F1C54108B" modified="2010-05-18" version="1">MQGLYPPTPELASFRGILSSATDANGHLIDYPLNGYQYPVISTYRAEDPMSAHISGHKNCPQHTNAVRAFAASKEFHDVFDSTQAFYSNIYSRILFGVYSRDMASIYHANTVYEYLNYQYTYNSTARDIISRTDVDTARQYANQWAHATSTGADVHWSKDRVLAIAGRSLAYPIMRSLQQNERSKGSFNKLSLIFGGYEPLMAFLEIVVSKPYREGLSGLPNHGASVMLELFSMAEDGIAEYPTDNSKLMVRLLIRNGTDASDPESQFKQYPMFGTNNKETAMPYKDFVDQMVFNMKSTSEWCRSCDGQENFCYQYAQHKSTKKCDFTTLPPLDTGALIGLGAVSFGLPTLALSCLFCMWRGHRHRKKLRWNHVDTENNASIINPGSSRDIRVSAPSSIAPSNESNAGSYNEDIEMLLSPACQPVKVRDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG01</accession>
    <name>D4DG01_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell polarity protein (Tea1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_06103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000345">
        <property type="protein sequence ID" value="EFE39191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019815.1">
        <property type="nucleotide sequence ID" value="XM_003019769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9584566"/>
    <dbReference type="KEGG" id="tve:TRV_06103"/>
    <dbReference type="HOGENOM" id="CLU_002697_1_0_1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1399"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1507"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="865"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="933"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1247"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="561"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1399"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1411"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE39191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1546" mass="171041" checksum="230C44943F5268E2" modified="2010-05-18" version="1">MSFFFKSSKKNQHQNQSQTQSHALNHNQPAPSGAATRNIHTSEGTGSVPTSSLSSSLNGIREIEKDVEPVQQFGPSTGPIPAPGQVNSSSAGPVQLPNAPSAANHALYPWSQRRMNFPSPQLTPFPRYGAAINAIASAEGDIYLMGGLVDGSTVKGDLWMIENSGNNSTCFPISPVTEGPGPRVGHASLLVGNALIVYGGDTKIHDNDTLDDTLYFLNTCEYNEAALNMFMDPSRQWSCAASPGPRPPGRYGHSLNLLGSKIYVFGGQVEGFFFNDLLAFDLNAMNNPGNKWEFLLRNSHDDGPPVGQVPPARTNHTMVTFNDKLYLRHANENNRFGGTNGVQWFNDVWAYDPRGNSWTQIDYVGFTPTPREGHAATLVGDVMYVFGGRTEEGVDLGDLIAFRISIRRWYSFHNMGPAPSPRSGHSMTTLGKNIIVLAGEPSSAPRDPMELGLVYVLDTTKIRYPNDQPTSPTGERPPPRRVAQNERTGGQSGRTSREAQHVIPDAQRRGPPGPARDPNGSPAGGSRLPRASIAQTPAGPPPSGQAPHPRTNAIPSQAKKQQQQQHPHQQQSQQQTQQHPHQQMQQQTQQHQQQPSSGKPDRSISSSSDHSRPSEKDRQHSRDTSVHGSNRGTRESSPMTAATRQQHSSSRLSARAMEAGEAAPMVTPARQRSLRQQRQQNSIDSVDDSILASENRAYRNSRSLADEPRSPRLTAHQEALIKELETMKTKNAWYVSELALARKAGYTPSSTPGTFEERSVDAFNEGDRPLVEMLLAMKTELAKMQANVDRQASIASKRVAEVEHQRDIALNEAAYARARLAAHGGGGGSQGGTPMSEMSNRDLDESNSQRTTEITRRLALSLTVQNELKAKVESLSLELQEEKRAKELAEELHEMTNKRLTELELQNNPLELESMRVELHQIQSSYREEAAARSEAEAALKMLQVDYAELAEKHEDISSRMENHGLNVVSLRDAVQASVAKAELMERKLEEERQHRDTVERKLLQLRAEHEERTNELENTARRLKEAEELADTHAKEAESHKIALLSGFDRVVSRGSDKGNSLADQRVAVLQSQVERANELVKTSQLAADSAAEKLRRAEERIAGLEAYQEQSSREGLQLRRQLQAALKENQTLSIENRDVKAQLENQQRDTNALAIQHGALKDLLGERGVNMSDSRRSPLLDSPGSRYGTPEQNRLRELEQQLQSSLKAHEETKSSFEYREQEVGRAYNEKLEQLENDYQSAVHYVKGTEKMLKRMKEELAKYKSQTAKLQAELAEVSNNPEAGASREAPAPAEWEAERDTLHQSITDLQSSTAASISSLENKLLAVQAELASVQKKYDESRNEQEALQAELSSTTEKGMRDLEQLKKENLLLESRAMDAEKKVSMLLDQVESSVTNYRRQSQQVANSMNSNGANLSRNASNASSAANANHTNRSRADSNVSQDDTLLNHRGSLALDSLANELDALRSHWETANRSYRISTQFDFDQTPTKETYGEGLSDSLANWRRRLDEEEARADEPSSSQHQQSSTIPTSQAAQPIAAGNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>D4DG92</accession>
    <name>D4DG92_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000348">
        <property type="protein sequence ID" value="EFE39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019771.1">
        <property type="nucleotide sequence ID" value="XM_003019725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DG92"/>
    <dbReference type="GeneID" id="9583682"/>
    <dbReference type="KEGG" id="tve:TRV_06194"/>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="269" mass="28099" checksum="D5C6194BA5B08E55" modified="2010-05-18" version="1">MADIEAAKRAAATEAVKNHYPKDAKFIGIGSGTTIVYVVEAIKALGIDTSATSFVPTGYQSNQLIVNAGLTAIAFDALPEGTVLDAAFDGADEVDDDLNCIKGGGACLFQEKLVALQAKEFICVADWRKNQSRLLTSWPSIPIEVAPLAARRVMDELKALGSPNPILRQDPVAKAGPLKTDQGFLIVDAPFPALLLPSDIAAGKKAEGGVWEVEALANAINAITGVLEVGLFCGPNGPQAQANGRVGGQKPVAAYFGNTDGTVISKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGF9</accession>
    <name>D4DGF9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_06263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000355">
        <property type="protein sequence ID" value="EFE39060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019705.1">
        <property type="nucleotide sequence ID" value="XM_003019659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGF9"/>
    <dbReference type="GeneID" id="9583609"/>
    <dbReference type="KEGG" id="tve:TRV_06263"/>
    <dbReference type="HOGENOM" id="CLU_004495_4_4_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE39060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27206" checksum="1AB73B4A72D4EDA5" modified="2010-05-18" version="1">MLWTLILNGTTGLIMLITYAFCVYDIDAVLKDQTGFPFISVFLHATQSVRATTAMTSLILVLQACSAISNVATTSRQLYAFARDGGIPFPSFFAKIDKRFVVPLNSLCVSFFIVCLLSLINIGSTVAFQAIISLGTASLLSSYIISISCVRLRRWRGEPLPPARWSMGRWSSTVETIAILFLLIAFSFSFFPLVSQVDVTTMNWSCAIFGGVVMFSLVYYILHARHVYKGPVTRIRPWAEAARIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>D4DGY9</accession>
    <name>D4DGY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000364">
        <property type="protein sequence ID" value="EFE38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019570.1">
        <property type="nucleotide sequence ID" value="XM_003019524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DGY9"/>
    <dbReference type="GeneID" id="9578344"/>
    <dbReference type="KEGG" id="tve:TRV_06444"/>
    <dbReference type="HOGENOM" id="CLU_2305386_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="101" mass="9786" checksum="7D11913978125A69" modified="2010-05-18" version="1">MLHSVGRLGFMHDIHAGAIVVVVAVVAAAIAVYGVRAGGGVGVGEDGIAVIIIIIIAAAAAVIVGVVAAAVVVARTAAGVVVTAANAVSDRRNGRVGDRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DH53</accession>
    <name>D4DH53_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000372">
        <property type="protein sequence ID" value="EFE38819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019464.1">
        <property type="nucleotide sequence ID" value="XM_003019418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DH53"/>
    <dbReference type="GeneID" id="9577914"/>
    <dbReference type="KEGG" id="tve:TRV_06508"/>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23711" checksum="8AAE0D014F3B8718" modified="2010-05-18" version="1">MFTACLPLPRGTSLAWGEKEHPERPPSSTNRAPSSLHHDTHANHDLPWQKIENMRQEIDDGLSKIEEQKARIKELEQENLAKEQEVTSLTHRNQLLEQRVETLEVTLKEAKTKASEAAQDSSQNEALQRRIQLMEEEAEQTDKTLRETNEKLRQTDVKAGHFERKVQALEATREQWETKYEEMSKQYAAVKEELKELERSISDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHJ6</accession>
    <name>D4DHJ6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_06652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019308.1">
        <property type="nucleotide sequence ID" value="XM_003019262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHJ6"/>
    <dbReference type="GeneID" id="9577630"/>
    <dbReference type="KEGG" id="tve:TRV_06652"/>
    <dbReference type="HOGENOM" id="CLU_074845_1_1_1"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="185" mass="20807" checksum="537FF78B24744B36" modified="2010-05-18" version="1">MYLFGVLFIKNLYVSLPATVHWGRCIYLLPIQPNHAYCLPCSILVFIITLLLLSADFYYLKNIAGRRLVGLRWWNEVNMQTGESHWVFESSDPNTRVISATDKRFFWLGLYSTPALWIGLAVLAIIRLQSVIWLSLVAIALILTITNTLAFSRCDRFSQASSFASNALSGGIAGNFATGMFGRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHK1</accession>
    <name>D4DHK1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000381">
        <property type="protein sequence ID" value="EFE38668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019313.1">
        <property type="nucleotide sequence ID" value="XM_003019267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHK1"/>
    <dbReference type="GeneID" id="9577635"/>
    <dbReference type="KEGG" id="tve:TRV_06657"/>
    <dbReference type="HOGENOM" id="CLU_005027_2_0_1"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055576" description="Glycosyl transferase CAP10 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="551"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="842" mass="94094" checksum="23FEB406AA3C72C4" modified="2010-05-18" version="1">MSSHGAPVTSWAAAALLCSVLVHRLAAGPVELCSEILCWLALPALFRAAGRSLGSRARSSRAGAGPLSLRYSPQRSSSSLSVWTAALCIVLSCLFRAEIRLLAFFDQPALTPLLLLAQRHFGSSTSFASSSSSSSASAAASSSWLFYPLANTLWGTLLVAVLFIITLSDWDFRGHALSALPVLALFGAYLTFMPKSDRKKKASLLPDVNVEDAVLPVSLRVVPLLLVSLAVEVALFGWPSGGVLATLILGFAKSLSWYSIIKAARYSSWCTAAATGTFGILSALSPFMQSSDTKALSHVIASLFALGQTIHTLPRHISNKSALWIFSLVSLGPFMANIIAIKSAYSSQLATYSKHPVETLIHRGTKDFEELLGRQSQNYTAAHAEYQRRYGIEPPPGFEAWYNFARSHQSPIIDDFDMIHTAVSPFLRLSGKQVLETMDRAQSTADSELWRCTFHGTRAKTQCHHPSRSFDRHIQLLFDTLLKDVPGALPDVKFLVNHLDEPRVIVPPGKKEVDGTQFKLTNLSRQPAWEPITKNCHSEDSHSGNRVETYGLPFVTNRTEDMNPCTHPEYATMNGLFMSPTSLRLFEGLVPILSTGSPLTMGDILFPSPAYIESEFQYDGKNDVEWHKKRNNLYWAGSTTGAFAQTGSWKHFHRQRFVTLAQNLETRKHKYIRETNGVISSVKSYFLNTRLYDVAFTKIFQCKTTYCREQRTFFPSKPWADKDKAFRSRLVFDIDGNAISGRYYKLLASKSTPLKQTLLREWHDDRLVPWVHYIPVSQSMEELPELVSYLTSTESGRRRAKEVADQGREWFSRAFRGVDMTIYIYRLLLELARLQDPERQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHS1</accession>
    <name>D4DHS1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_06728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000386">
        <property type="protein sequence ID" value="EFE38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019239.1">
        <property type="nucleotide sequence ID" value="XM_003019193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DHS1"/>
    <dbReference type="GeneID" id="9577479"/>
    <dbReference type="KEGG" id="tve:TRV_06728"/>
    <dbReference type="HOGENOM" id="CLU_082473_2_0_1"/>
    <dbReference type="OrthoDB" id="5422293at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="248" mass="29582" checksum="F67816D0A5842B33" modified="2010-05-18" version="1">MPKLRTLPFWLAVKVFIRRIIYKLKTPLNLRGSIAILRHNHKHPYLTLLRLFIPWPTWRFPLPEPVPAKEMLGNEALMNRRRRSFNQYMSVPIWRIRDTPLRSLHRLYESMASGEYTPIGRETEYFWYRGWPLETIEDPQDPDPIRYAIIASLVEELVSAFNWRLSLGMRRNHQHVLRSSDDDPYPPYIPLSGPRWTEHVPPIMPEHLERLPLGFTNEEHQLVLEEKGCNKIFLKRNIVTNVGWLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D4DHU3</accession>
    <name>D4DHU3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vacuolar protein sorting-associated protein 1</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TRV_06750</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000388">
        <property type="protein sequence ID" value="EFE38556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019201.1">
        <property type="nucleotide sequence ID" value="XM_003019155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9577198"/>
    <dbReference type="KEGG" id="tve:TRV_06750"/>
    <dbReference type="HOGENOM" id="CLU_003614_0_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="17">
        <location>
            <begin position="921"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="16">
        <location>
            <begin position="1501"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="790"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1423"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFE38556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1588" mass="174769" checksum="32C98142B5BF1591" modified="2010-05-18" version="1">MILGLGRPSFRPRPSLLGLVSAASTSSAAAAAAAGAIDGDGDACSALKQHQDPTPPRSFNFVFTTNNNNVNNNVDDTTSSNNNNCRYSKDDEREELDESEDSHSVDGSETESTSSSSTAPIETRSPPAMAPKDSKEEAGDEQKGVVFSISGPVIVAENMIGCAMYEMVGCSFDPLPFGGLFTGWIADYDDACSAMLESTKSLEKSSESQETRPPSRSTRRQPLSVELGPGLMETIYDGIQRPLKSISEVSNSIYIPRGVALPALDRKKKWAFKPAGLKVGDHITGGDVWGTVFENSLLYDHKILLPPRARGTITRISGPGDFTVEEKLLEVEFNGKKTEYSMMHVWPVRVPRPVNEKLASDSPFIVGQRVLDSLFPGVQGGTICIPGAFGCGKTVISQSVSKFSNSDIIVYVGCGERGNEMAEVLMDFPELTITIEGRKEPIMKRTCLIANTSNMPVAAREASIYTGITIAEYFRDQGKNVAMMADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGQTTALGSPERKGSVSIVGAVSPPGGDFADPVTTSTLNIVQVFWGLDKKLAQRKHFPSINTSISYSKYTSILDKYYAKEHPEFPRLRDKIKELLSNSEELDQVVQLVGKSALGDADKITLDVATLLKEDFLQQNGYSDYDQFCPLWKTEYMMKAFVSYYEESQKAIAQGQSWAKVREATSAIQTALRNMKFEVPDDEKEVTAKYDKILQDMSEKFASDQGEPAKPFIIIIYPARRSSSLSLSSPPSSINIKSINTQAACDEGQLHVNRPKNSPKHRTCSKRPKYTRQENIPSPTTTNPCPTTTSSPRQLLWSCSSSSPVPPSARLYIISPDHGGPSWLFVSTLLRLLPKHTKPTIGHVANAGNSPGCRISVNDPSLISLVNKLQDVFTTVGAQNPIDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLVLQLINKPRSEKQSNGVKEEDKLDTTDSEANIDEYGEFLHIPGQKFHDFNKIREEIVRETDAKTGRNAGISPAPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPKDIEKQIREMVLKQISKSNAIILAVTAANQDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDAGTDVVDILAGRVIPLRLGYVPVVNRGQRDIENKRTISYALEHEKNFFENNATYSSKSAYCGTPYLARKLNVILMMHIKQTLPDIKARIASSLQKYSAELNQLGDSMLGNSANIILNIITEFSNEYRTILDGNNQELSSVELSGGARVSFVFHELYSNGVKAIDPFDMVKDMDIRTMLYNSSGPSPALFVGTGAFESIVKQQIKRLEEPSLKCVSLVYDELVRILAQLLNKQPFRRYPQLKERFHGVVISFFKKVMEPTNKLVKDLVAMEACYINTGHPDFITGHRAMAIINERQNASKPTQVDPKTGKPLPPSATMPQRSASPSLDLGDSSPGFFGSFFSSKNSKKKMAAMEAPPPILKASGTLSERENTEVEVIKLLINSYYNIVKRTMIDMVPKAIMLTLVQFTKDEMQRELLGNLYRAEEPDDLLRESEFTVRRRKECQRMVESLTKASEIVAQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI56</accession>
    <name>D4DI56_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_06864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000397">
        <property type="protein sequence ID" value="EFE38464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019109.1">
        <property type="nucleotide sequence ID" value="XM_003019063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI56"/>
    <dbReference type="GeneID" id="9582598"/>
    <dbReference type="KEGG" id="tve:TRV_06864"/>
    <dbReference type="HOGENOM" id="CLU_508245_0_0_1"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE38464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="536" mass="57635" checksum="A23BFD703C39C0A8" modified="2010-05-18" version="1">MHLFGGQRSKRDTAEKKKKKKKKRKKKAAGVAYRERGDKKGPKRRWLDAVRKERQRQRAVKEESSCRVGEGHQEPQQSSEKASSELEGMEAEKKRLTCDCLTELVGFIVNSEDGEEASLSLAMVSQATPQGRQTRQTDKITRQTVNPQARSDDGSGQQDRHIDKQVAHRSLPHSLAGSEKKQRAVNAQLSLPSHLASMDEKTGDKHEKQQKQPQSADRPSSGSTSMADRIQSSAAGLLKSAITPSASTPAGSYAFARDVSSSLAGVSSSEKAGGASSSSSSAARPGAAVEGGIHHGSSSTQPGSALRSLPSQGMQSSLVDQEREFQQGGLPVDGDTADGAGTGYISTSTTSSKGKGREVDMGDEQFDSAWKSASSNATPSAVTEQERRDGQAVSDLLSSATFDPSSLPDTDPDELQPEPEPDMSFLTTNQRGEQQPDISSTSLIPDIDFVLSSLRGIPPQSQVEHLRDLPGVAEWLDLDREYQDVVWGSLKPAVEEARQEVQEKLEKGEQGAAVGDGPAVARLRMVLAHLKEKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DI96</accession>
    <name>D4DI96_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1 snRNP splicing complex subunit (Luc7)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_06904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000399">
        <property type="protein sequence ID" value="EFE38434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003019079.1">
        <property type="nucleotide sequence ID" value="XM_003019033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DI96"/>
    <dbReference type="GeneID" id="9582565"/>
    <dbReference type="KEGG" id="tve:TRV_06904"/>
    <dbReference type="HOGENOM" id="CLU_030397_1_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30134" checksum="5E6C9E5722DEAAD6" modified="2010-05-18" version="1">MAAEQRKLLEQLMGVCRSYLAGTCPHDLFTNTKQDLGPCPKLHSEGLKAEYDAASSHEKAKWGFEYDYLRDMQKYIDECNRRIDSAQRRLEKTPDEIRQTNHLLSQISDLNKTINAGLEETSVLGELGAVATAIDEFYKVRTAKHQKESLERDLKALADTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHLGYAKMRETYSILQKEMKGQPPSRHDDGPSGRGDAGFDDAGWGRDGGGGYGGRSYRGSGGGHRRKGGGGGYNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIQ5</accession>
    <name>D4DIQ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TRV_07065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000408">
        <property type="protein sequence ID" value="EFE38288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018933.1">
        <property type="nucleotide sequence ID" value="XM_003018887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIQ5"/>
    <dbReference type="GeneID" id="9582093"/>
    <dbReference type="KEGG" id="tve:TRV_07065"/>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFE38288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="409" mass="47189" checksum="AE2588E50661325B" modified="2010-05-18" version="1">MVPPKSGNRPLRRWIYLASPFLSFLVAGYLFLSNYPLYYKDNGALNIPSSPSEEIPRIIAGLEDVHVVLKTGATEALAKVPVHFNTTLRYVPRFTLFSDYEEDLAGCHIYDVLRNVDAAIKDKHPEFELYRRLRAAGRETLSNTDPSNDVSTPAGKPNNPGWILDKWKFLPMMHETLRIRDDAKWYIFMEADTYIVWKNLVIWLENFDSSKPYYLGNQMQIGDTIFAHGGSGFVLSQAALKRVVEYHSSLVKEWDTLTGEHWAGDEILGKALNDAGVGLLWSWPMLQGSTPWNFDPFSSSYNKLPWCYPPITYHHMGSEDIRELWEFEERWFEEKLTQPRFNATGEDRDNDSRDIAAGVETAAECERHCTKDLECLQYSFGDKLTFKISYLYVHLLRLCFELKKNNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIR5</accession>
    <name>D4DIR5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_07076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000410">
        <property type="protein sequence ID" value="EFE38262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018907.1">
        <property type="nucleotide sequence ID" value="XM_003018861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIR5"/>
    <dbReference type="GeneID" id="9582064"/>
    <dbReference type="KEGG" id="tve:TRV_07076"/>
    <dbReference type="HOGENOM" id="CLU_712106_0_0_1"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003055555" description="Isochorismatase-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE38262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="388" mass="42337" checksum="D03711AE4058D509" modified="2010-05-18" version="1">MVSLKLAAILLIPSAIAGVIKRQDDAEVLAFTGPQCDGTPDHPVSLDTCEERFIEDRSWVLTVYCVSPSSGEIESISVPSNIVCQTYDKLVHIVILNPMYITLRPLVVAHPQLRASPQPRAKTPAANMAIVSNTAALPGSCLRRNYSQPLSSLGLYTLPPWQTPEPPASVSIVLLLPLRLIRTDRLPGNPALFICDIQERFRTITYEFPKLVSTSLKLLRASKPLNIPIYVTTQNTARLGPTVAEFDEYLQQSNPNLRINCDKTLFSMITPEVKEKLPNATSEKPLDAIIVGLESHVCVTQTALDLLSLGHRVYIIADGVSSANAEERHVALARLRDAGAIVTTSESILFEIMGDSKIGVFREISGLVKETGKETKGALEAFCSASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIT7</accession>
    <name>D4DIT7_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000414">
        <property type="protein sequence ID" value="EFE38227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018872.1">
        <property type="nucleotide sequence ID" value="XM_003018826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIT7"/>
    <dbReference type="GeneID" id="9580044"/>
    <dbReference type="KEGG" id="tve:TRV_07098"/>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE38227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="494" mass="53969" checksum="9A8CD22D8D1C18B7" modified="2010-05-18" version="1">MPGVDGREIKLSRGRFLGGCSGCNGTLCIRGCKQDYDDWGLEGWSGEEFFKCMSKPWLESAEGVHGTSGPIHTEPHDLAPISKRILDSFISKGIPYKGDLFSTGEVPHGCGHVVRTVHKGLRSTAADYLTKGNRKDNVTILCNTSVDKVIIEPREGSLKATGVAAISTADKTHRTFQATREVIISGGAYCSPAILLRSGIGPKEELDKHGIPCKINLPGVGKNLMDHLIVAIFYETEEGLTNDHLVYHEGAFEKSYSEWKERKSGFLSSFPFGAFAFARVDDLLADVPAWKNAPHEEGRDPMGLAPCQPNIELFNTECYGGPKHYNIFPTNSHTFSFIAELFGPRSRGSVTLKSTDPLDPPAVDCNYLDDPLDMLVITEACRLGNEILTEGLGTKDIIKGSWPPELKHHTFKTRDEWIPYVKEHGTTCYHPGGTCAMGKSDNPNAVLDEKLRVRGVAGLRVADCSVMPTLHGGHNQMPAYGIGEKCAEIIKNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DIW2</accession>
    <name>D4DIW2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TRV_07123</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="ACYE01000415">
        <property type="protein sequence ID" value="EFE38210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018855.1">
        <property type="nucleotide sequence ID" value="XM_003018809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DIW2"/>
    <dbReference type="GeneID" id="9581499"/>
    <dbReference type="KEGG" id="tve:TRV_07123"/>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="90"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EFE38210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="335" mass="37013" checksum="F97BB4C80177D9D1" modified="2010-05-18" version="1">MSKATFAIIAAAGVATGAGVTALLYSSSSSRRQPHEPLPAARGPSPPSATSPVTAAARVPPPALPTSRYPVDPSGLFQYGFPGPISDVIDRPSLTAGFDRRTRNPAWVVEHITPESVAQRDGDRSHSQFYEEESIPAAFRARLSDYYRSGYDRGHQVPAADAKWSQEAMDATFSLANMCPQVGEGFNRDYWAHFEDFCRRLTQKYPSVRIVTGPLYLPKRDPADGKWKVSYEVIGNPPNVAVPTHFYKVIFAEDGNGEYGKVSLGAFVLPNARIPNEKRLQDFEVPLEAIERASGLEFASKLLPYRRGVLCQEVKCDITVREFKKANDRKNLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJ08</accession>
    <name>D4DJ08_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_07173</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000418">
        <property type="protein sequence ID" value="EFE38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018813.1">
        <property type="nucleotide sequence ID" value="XM_003018767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJ08"/>
    <dbReference type="GeneID" id="9581373"/>
    <dbReference type="KEGG" id="tve:TRV_07173"/>
    <dbReference type="HOGENOM" id="CLU_019713_2_0_1"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="699"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="302"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="591"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="751" mass="85440" checksum="D49A0F8C5B54861D" modified="2010-05-18" version="1">MEDRKRLATQDPGDSAPPLKKQATTVNGGVKAHPDTDMPWRDDLEVRKALSSYLHAMSMDETVFVLTYSVAFAYFFFGQKVLTHYSFFTQRYQKDAIWRQMQEYKREKTTLESRIKDLSKKMAYNEEHVSVLDAWLKQLIDEVKVISSSVDESSEENPTFQTSLLFSGHESFEKHLQDRASEIKGSISRLLSNAAKATPDITSLQSQLAKKLADEKAINVAIEKAIAEKQQLEERLEAASLRYMVAEKKIDRAKSLTVARLEKQHILGPHKSGDSSTKRDEGPSTNGTTDNPEKATEMEMLYNTTLAVSNKQKEQLERLEAENSKLLTQITELHVKLSKLSDEDYAHCDLFKQLKSQHEDVIQRINHLEATNIQLREEAEKLQAERTAYRVQIENEAQTTIGEKEAQLAKTEFNLVRIRNARDELLADQQMRKAVEDQEKHSVTQLKELLDAKESRITSLEQEVQRVQLQIDGVKDSRPNSSELSHEELRTKFDTLEKQYEMLNMELSSMQMAFRKSSKLASQKIADTAAAEERAQRLMAEKSKADQKYFAAMQSKESRDAELRSLRLQNMKSSDIISQLKEAEAATRTLVSNVEKQLSETKEALTSLTNQYRTSQHQVNEATIVIQGLKSQVAELKGQLATKDATLTAATNNCRKAESEVEGLKVTLSDTKKSLESWKSRGLGNNTSEYEMLRTLALCTVCRRNFKNTVIKTCGHVFCKECVEERLTSRSRKCPNCNKSFGSNDHMHITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJL5</accession>
    <name>D4DJL5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000438">
        <property type="protein sequence ID" value="EFE37978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018623.1">
        <property type="nucleotide sequence ID" value="XM_003018577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJL5"/>
    <dbReference type="GeneID" id="9580774"/>
    <dbReference type="KEGG" id="tve:TRV_07383"/>
    <dbReference type="HOGENOM" id="CLU_006603_0_0_1"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1127" mass="121143" checksum="C3BE268256BEA635" modified="2010-05-18" version="1">MDMDQACLKGMDSPPQSAEEKSSKDAAQKAKGPRKRTKTGCLTCRKRRIKCGEEKPRCNNCIKSKRECEGYGQRVVFRHPVGPIPHLGPIRQIQGMGGMPGMPIMAGAFGHSMQQHIEAASASRPALLPIAPRPSYHHAHPDDLSRHHQAYSSAADPYAASTQHHSAINPDQPPYTWDSVSYSDGSYIPTSSAAAAVSTAAAGSAQHYVTSTSSSSASYPPSEAPYPHQEYAYEDTTAWEDAAQLQPYEAAAVYQAQLSLQVCSPLSSPPFPLFSFSSNVRHDHVSTTTSTSTSTSITTTYTAAAACSASSATLVPKLESKEALLFPPAPDANDAPNQCRQQHSLVMHDVGEESDDYFDVESDEELEDQFSAPSAATTTAAAAAATAAGTACYAVPGKGSLYYPSSALAVSNPPFASYMNYDNLLATYRPSPLTSPLIDPEVAKLFSHFIGSIGTIISIFERKHSIAPLLSFSLLPTEQQSLFTYTLPTLALENHGLLHSILALSSVHLAYTTGQSSTAAFRHYHFALRRISKAVGLPHRRKQIPTLAATLLLGFFEVLAAEHSKWCSHVAGASQLIREIDFASMTRRIRAMRARARKQKSVAGERSWTRAGDFRLDTFFENDIYAPIEREIDVDLVSAIMGRDADYDALPAEPAVDQPLTAKDIEDHRIRTDLYWHYCKQDLFQSLISGNPLLLPYEKWAQTPPRSAVGRIQTAYGTMDHLLLLLARISAFGVRDRKRKLKAMEKNGGEWRPPPSMFPPPATAPDGPPSRPKPASAPPPAPPPAGPPGPASGARGQAANQGKSPPMYGMLPAGPVKLFSGFAAAPGAGPTQQTAASPSTASSSDETDLDIRTAQAEAEWQDILAACERFEQAMGPAFAPLPPDGAPLITSPFGPALQYRTHIIGCIWGLYYMGRIILHRFHPSMPPAATMAAVVAAPTTAQYAQNIGRVAAGIPYDHRLSSTSSASSYAHPSSSSFSSSCPPAGASSNLNVTIAGVLHELTVCLFFAAVQYVDPAQRAWTVAMLRDISIITGSKSPIAIARGCETSWIKAAEAGRGPPHQRMVFDFDPSDVCSREGVVPDHGDDRRWTAVHRGSSISWAMGLLSIDGDYAVAEDRHNRGSPSTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJY6</accession>
    <name>D4DJY6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TRV_07494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018481.1">
        <property type="nucleotide sequence ID" value="XM_003018435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJY6"/>
    <dbReference type="GeneID" id="9584410"/>
    <dbReference type="KEGG" id="tve:TRV_07494"/>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFE37836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="135" mass="14396" checksum="38FDFC7965B2AF1B" modified="2010-05-18" version="1">MPGGKGKSVGGGKAAPKDANGKGPRSHSAKAGLQFPCGRVKRFLKSNTRNKMRVGAKAAVYTTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAYGGVLPHINRALITNADKKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>D4DJY8</accession>
    <name>D4DJY8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TRV_07497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000446">
        <property type="protein sequence ID" value="EFE37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018483.1">
        <property type="nucleotide sequence ID" value="XM_003018437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DJY8"/>
    <dbReference type="GeneID" id="9584412"/>
    <dbReference type="KEGG" id="tve:TRV_07497"/>
    <dbReference type="HOGENOM" id="CLU_3279815_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFE37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="41" mass="5103" checksum="49D31900D913FFB2" modified="2010-05-18" version="1">MQVVKEEEEEEVREVKSRWKLVQEEEEEKKDDEVLGRSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>D4DK33</accession>
    <name>D4DK33_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_07554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000451">
        <property type="protein sequence ID" value="EFE37781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018426.1">
        <property type="nucleotide sequence ID" value="XM_003018380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DK33"/>
    <dbReference type="GeneID" id="9584355"/>
    <dbReference type="KEGG" id="tve:TRV_07554"/>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE37781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56786" checksum="A8725FFED19C821A" modified="2010-05-18" version="1">MDQDQFRSAAHSAVDEIIQYFAGLPSQQVLPDVEPGYLKGRLPAAAPLEGEPWSQIQADLDTLVKPGVTHWQSPNFMAFFPATVTYPSILGEMYSAAFNAPAFNWLCSPVVTELEIAVMDWIAKALGLPDCFLSTSPTLGGGVIQGSASEAVITVMVAARERYASDMARAEGLDEGSEQWEDRLIEIKSRLVSLGSDQAHSCTAKGARIVSTRHRTVPTRLKDDFAMTGDALREVLEKCEQDGLMPYYLTTTLGTTSTCATDRFAEIKAVLNERESWKKIWVHVDAAYAGAALICDEYQYITRDWSEGVDSFNFNMHKWLLVNFDASCLFIRNRVDLTSALDITPHYLRNPHSDAGAVTDYRNWQLPLGRRFRSLKIWFVLRSYGIKAMQAHIRKGIDLGMTFAGLVRNQSDLFELVTPPAFGLTVFHVTEAAARQVAGGDSNSVTREVYERVNAGKEVFLTSSVVEGLYVIRVVSANELAGEKYVRNAFDILVRVTREVLDSPSSAEKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKG8</accession>
    <name>D4DKG8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000468">
        <property type="protein sequence ID" value="EFE37666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018311.1">
        <property type="nucleotide sequence ID" value="XM_003018265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKG8"/>
    <dbReference type="GeneID" id="9580007"/>
    <dbReference type="KEGG" id="tve:TRV_07690"/>
    <dbReference type="HOGENOM" id="CLU_082207_0_0_1"/>
    <dbReference type="OrthoDB" id="4172697at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="356" mass="39471" checksum="39CB3093404A7A49" modified="2010-05-18" version="1">MIRKKQSNNQTSTSDGEAKQQPDEQKRPAEEDKEKEDIKRHPGSKQISRQRPSMQVSTANASASRHAPDGQPSPANSASATPTNNSPSSPGPMSAQPQLPHQPLQGQSRQLRPLKTPLYVPAALRRTERPPKPSPLTPPRSVHGSVDGQDGQDGSITPTENLSRRSTVDSTRSGVSRLAQDEWLRDQNLGEVTGSPTREHWKVDSPLPLSQHTYLDIPGTRADSASPSCDSPVCKSFFGIFVRRHHCRHCGHVFCSSHTPYTIPLDQNARFHPDGIPSRSCDLCWAAYRRWEQARTDQLNQIQHNLIANLNAPERSRGWAIEADRLSIADPDADSDENQDGMIATSVPRDWSWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKJ3</accession>
    <name>D4DKJ3_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_07715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018265.1">
        <property type="nucleotide sequence ID" value="XM_003018219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKJ3"/>
    <dbReference type="GeneID" id="9579961"/>
    <dbReference type="KEGG" id="tve:TRV_07715"/>
    <dbReference type="HOGENOM" id="CLU_003875_0_0_1"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="896" mass="99854" checksum="1DE64A3EA3C11E02" modified="2010-05-18" version="1">MTSSIKQRPTSKVPRTPRRDVLAPLKLAQIEVVKPLLPAGMPWTACFIDLLYSHNTNVIVIEIMASILDYLSPTDLITVARTSKKMHEMVYDDTRWVRFLKQIGCWNEAEARSAAEGSEKDADRPHGGKTRSRPTTTELDSHKSNGNITDTGGFDIVEFNAEVEAEITGPLAALRDARSTRGRAREEYGKIHESLNPYYQDIIKMENPTDSSVFKSYDKPEQQALLLSELNRFSNVDMGLGSTARRKKLTNVISVFERAALREFKNGYENGNSDDIMPRYAQVLTTLNGGAAAVELLIYQNHIIKQKADFGSPMDGFDADTGTVSLNHTHAFLTRLSVAFNEEATYINRCFPNGPNVSSLFLEKICKDILSPYFLPLLDLLQSTNKAAYIQTLPGTFTQSLNFIRELNPIQVSSDKFKELAREAIERTFEPHVDLYLAEELDQFRLHSESIVGDWDRQLSEQAASTESLYMSNIHNRQADKRDFLSSFTKVIMAPVNMIPGLYKSTEPKKGGANKAMAKATQSSSRSSVILAPPTPPTPAELPTTEFAAKAAIMNSKLEGIRSLFSIEVALNLVHAAKSSLERTAQFVGLKGGLGKAAQAQCEAIFVSLLDSLGHRHVIAGFDRAVNHLSEYRPRKQAEEKSGVEPLVTFLELVNVGDLILQMLDVFYEQELVAAGLTDRNDFLDPAVKGKRKFEQKLDERVAAGLNKGIDVLVEEVEHLLATKQSIGDFHPEAVDPSQRTADIGPSEAAKAIVQVISSHTRMLIGGTDKSTLDVFNQEIGLRLFNALCKHIKRHRISIEGAVKLISDMNHYFGLIQSMRNEQLLLYFKALRELSQVYLIDTSDSKEIASIISDASRFHGIFRAEEAYEFAERRADWYQVKNSVEKAMYGVGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKK5</accession>
    <name>D4DKK5_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_07727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000470">
        <property type="protein sequence ID" value="EFE37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018277.1">
        <property type="nucleotide sequence ID" value="XM_003018231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKK5"/>
    <dbReference type="GeneID" id="9579973"/>
    <dbReference type="KEGG" id="tve:TRV_07727"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="247" mass="26934" checksum="7DE99EA5BBA5D346" modified="2010-05-18" version="1">MASNPPGECCIRGFIHEGTATGEIKKMGDLDVYFAHPKESCKKAGKAIVILSDVMGIRINAQLLADYMASQGYLTVIPDLFRGDSLKPAVFEPNSGFDRQAWFAKHGTNAVDPVIESTIKMLREEHGVERLGGVGYCFGGKYVCRFLKDGKLDAGFTAHPSFVSRDELSAIEGPLSIAAAEIDEILTTALRHESEEILAKTKQPYQITLYGGVSHGFAVRGDLSKPDIMFAKEQALAQALAWFGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>D4DKL6</accession>
    <name>D4DKL6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_07738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000471">
        <property type="protein sequence ID" value="EFE37606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018251.1">
        <property type="nucleotide sequence ID" value="XM_003018205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DKL6"/>
    <dbReference type="GeneID" id="9579867"/>
    <dbReference type="KEGG" id="tve:TRV_07738"/>
    <dbReference type="HOGENOM" id="CLU_082854_10_1_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="132" mass="15090" checksum="1BA0CD9BCDBE8B1C" modified="2010-05-18" version="1" fragment="single">TPPTPDSQVTNIKTKTVKMPKEKTTTRKTKRGVEKKKKGKLILSLTLWQPQAMANRWTVDPNAPKRGLSAYMIFANEQRAAVREENPNITFGQVGKVLGERWKALSDKQRVPYEEKAATDKQRYEDEKAAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>D4DL18</accession>
    <name>D4DL18_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TRV_07892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000489">
        <property type="protein sequence ID" value="EFE37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018101.1">
        <property type="nucleotide sequence ID" value="XM_003018055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DL18"/>
    <dbReference type="GeneID" id="9579310"/>
    <dbReference type="KEGG" id="tve:TRV_07892"/>
    <dbReference type="HOGENOM" id="CLU_051221_1_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFE37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="404" mass="46696" checksum="08387A26388258FF" modified="2010-05-18" version="1">MVQEIKMNSAFKFVTSTPRITSILGILIPIAWVAVSVLPFVFAFSRQPGLGRNIYYLLLTGCLTLGFITSSRLPAGIDWLWAFLCVIGIIHQSAGLLLEPWVVPVANQSVNHDILYLGLKLWGNPRRLRVCQLGQKNSVSWQKRLTFVFQKVGLVLLLGILYLMGEAVVALVLYPLPMKWRVSFRYYFGFKPDHPVLVRAVFCVHWAWESFVFLTIGHAILAILFVGVLGVDIPSEWPWLWGSPGEVYNLQRFWGIFWHKIGSVSQLEWGRYLSRRVLELKPGSPREKVFLAFFIFMASAIIHALVSWSVKDKSESVARIYNFSLFLIFNFLGTLGEYGLKQLLRHHCPQFRGRFEPGIQLWRRLFGFLWVFLFFFCTLPPWEYPYFPGYANQVKVNFNVIRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLB1</accession>
    <name>D4DLB1_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TRV_07985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="ACYE01000501">
        <property type="protein sequence ID" value="EFE37362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003018007.1">
        <property type="nucleotide sequence ID" value="XM_003017961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579135"/>
    <dbReference type="KEGG" id="tve:TRV_07985"/>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1245"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1292"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1357"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1401"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="1181"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1456"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1477"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFE37362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1501" mass="168896" checksum="A8BD9624BBCB5280" modified="2010-05-18" version="1" fragment="single">PTSGQQQQEQESPQNIHDVDQRRHSLNRVRFSSDIDRVAEQTGSISRESDSDETSPATTPVSASPGVLPTGRNRGYSLRRALFNRNLVTQQQPEEPDLERNEASTSGQTDKKTIDTVTSQKVATEKEDYSFLPQHSDFLKSTTSFLTAKPRQTFSITHTINSWLALLLSLFKTHVLRIKDIPPSADGRYVDLDAYNSKPRIDERTGKHYVSNTIRSSRYSLWSFLPRQLIAQFSKLANFYFLCVSILQMIPGLSTTGTFTTLAPLLIFVGISISKEGYDDVRRYRLDKEENNRITSVLRPSQEVQDGSYESLPMTAGDMSSKATDHPQPWTNVKWVDIKVGDIIKLERDQAVPADIVLLHADDPNGIAYIETMALDGETNLKSKKPCPLVAKTFNSTDDIINDRSTHFVLEDPNMDLYKFEGNVTVGDETAPLTNNEVVYRGSILRNTHEAIGMVIYTGEECKIRMNATKNPRIKAPAIQGVVNRVVVLIVILVLSLAGACTIAYKYWSRSTERMSWYLEQANVSFGPIFSSFLIMLNTMIPISLYVTLEIVKVAQMFLLNDVDMYDKTSNTPMEARTSAINEELGQISMSVAGTAWLHDPDLVQEAANETTKQILLRRQSKGKKPTRAKSFGDSSQGRPSAVSRRSGVSQATARESGTWKPCKKSRFYSGGKTTEMLQYVKQKPHTLFAVRVRFFIIAMALCHTCLPECGQDGEYTFQAASPDEVALVTAAKELGYLVCDRQPNSITIRRSEGNNKSNDTIEETYEVLDIIEFTSSRKRMSVVVRLPDGRICVFTKGADSTITKLLKQSSLAIEKIHQIEHRSNERKAMESMEIIRRNSEHMSRGGKKSLSIRRPSFVGRRSSVSGKPGPSIRQSIDVWLRDRETDGGLDIKDDEHEMQNYNPRPSVQLGNGGSPRVSFQIDDGMVEEDLVDESLVTNEALVFERCFQHISDFATEGLRTLLYAYRFIGESEYKEWKQVYKEATVSLVNRQEKIDEAGAHLETQLELIGATAIEDKLQKGVPEAIDKLRRANIKLWMLTGDKRETAINIGHSCRLVKDYSAVFILDYETGTVKQTIESTVSSLRAGGVVHSVIVVDGQTLSVIEGDDGLRELFFELAIRADSVICCRASPKQKAFLVRSIRKRVNGAITLAIGDGANDIAMIQEAHVGIGITGKEGLQAARISDYSIAQFRFLLKLLLVHGRWNYVRVCKYTLGTFWKETLFYLTQTMFQRSNGFTGTSLYEPWSLSMFNTLFTSLAVIFLGVFEKDLAASTLLAVPELYTKGQRNEGFNIPVYLGWATVAACESMMVYFVMIRLFGDAIFTVDNGIYAMGLLTYSACVIIINVKLQFLEIHNHTVLTLIPLVGSIGIWWLWNIILSKQYKYHAIYNVRDNLIHFTGKNALWWTTLIVIVAIVILFEITKVTVRKTLWPTDVDLFQGYEKDGDVKRRFEEAAASELAQGWERPGKYGGNDDDGASEEDHEHELQLQDLIERRTKEEHQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLF0</accession>
    <name>D4DLF0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TRV_08024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000503">
        <property type="protein sequence ID" value="EFE37328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017973.1">
        <property type="nucleotide sequence ID" value="XM_003017927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLF0"/>
    <dbReference type="GeneID" id="9579851"/>
    <dbReference type="KEGG" id="tve:TRV_08024"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_6_1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFE37328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="541" mass="57743" checksum="559661F4D46C739C" modified="2010-05-18" version="1">MPEKEIENVICQDGVLDANANGGAKDMGELESGHTQEERGREEEAAIYSAFKPGTKIFILAMATFSSLFSPMSTTVYLPALTPISADLNVSTNLINLTLTTYMVFQALSPTFFGDFADTSGRRPAYITTFAVYLAANIGLALQNSYPALLVLRCLQSAGSSATIAITMGVMADIATVSERGRYVGMVLTGTLVGPAIGPVLGGVLVQYLGWRSTFWFLAIGAGVFLVPYVLFVPETCRNVVGDGSVQPPWWWSRTLMDIWKGKKVRPSKVEWEASLADQGIKRRTSSFPNPLQCARLALEKDIGLILGVTAVLYGAFYIMLASVPSLFKEIYGFNEFQVGLCYLPSAAGGIASSFSIGHLLDWKFRRIATSLGLPVDRKRAQSLKEFPIERARISLMLPLLYAGMATMVGYGWALEQRAMLAGPLILHNEHAAGGPVPVQPVSGDGSKQPDPLPSGSGGNGIVQPSDRADWNRLVLHGVVSVDCGGVSRSLGSYPMGSSMEGAAAAAAAAAAAGIISLTAAKETHASDRAAMVTLNKRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>D4DLT2</accession>
    <name>D4DLT2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_08156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000521">
        <property type="protein sequence ID" value="EFE37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003017833.1">
        <property type="nucleotide sequence ID" value="XM_003017787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4DLT2"/>
    <dbReference type="GeneID" id="9583731"/>
    <dbReference type="KEGG" id="tve:TRV_08156"/>
    <dbReference type="HOGENOM" id="CLU_008976_0_0_1"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE37188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="822" mass="93095" checksum="1D79ED3E4E5B6AC7" modified="2010-05-18" version="1">MLPHYLTSSYLQYKQDTNAVASWLAKTAKVCGYEIEHQSDQPKKGGRAKGKARKAARAAQSSTNSSTKSSASVKPQTYVIAVRDFIPLAETIVKCEAPRVRVPSTFITAIERAISARRSHHSILGEKRKTNEDGHGHFISVLERVQNILRPLFVDENKEGLANKFEKLDVEEPSDERAPTPDTTKPEPPESGSDATYEAERAQDINEMYSAYCLIIQDYRAFRIAIQETWLGYRDGVFDLVSASIMTNTALEFARQLEKDAAPLFNKFGGSAMLMEAVFTAQCHNMGEDKDFRELPGDDLNFRVWEAATEIFFPTYMFLQGFVPMVSKDNMPVIKPGYFGVYDPASDRINKSPREKFQEDKVILMEHSTEFALLCICAPDLLAEDELTRSFAEAFQTHSVTLFLSFATQVYLDIHHTLRGDVRRGLSDLMATANMIDESINDNFQYHKSLRVTGWPRSNDTVLENIQQFIGLWVKRDPVGEARRRLKQPPREPYMLLSSHPLLCGLITYSLKAKFQEVSLAFADAWGSILYTYHLYNAVKQEKLLRNNWQDMDVIMGMQDKIFVGDRPQTPEDYLKQFALSMGWSAAAFSKNRRQGALPVSSRGPRTLKELAPVAQMFKPRFCEGALQRDWTTTDIEQIISKSNWSWDEEASPSEGIRVYSMSRNIKKEQKKATSGAVNAAELLKQLRNTLRTESLELSIPYLSFHRICWSVLRSIHEHCRPTLRDMFGGGYMERENQLPFVVGYIFMAATNTKKLSGLLGAKKSDEVTSKLLSEAAAAMDECIAAVGKQCCDMLEQLNFRFTDGMDDEVEGEGDKDKNERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4CYZ5</accession>
    <name>D4CYZ5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_00032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="ACYE01000002">
        <property type="protein sequence ID" value="EFE45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025770.1">
        <property type="nucleotide sequence ID" value="XM_003025724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CYZ5"/>
    <dbReference type="GeneID" id="9582013"/>
    <dbReference type="KEGG" id="tve:TRV_00032"/>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="267"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="458" mass="49383" checksum="CCD92CF049E81A37" modified="2010-05-18" version="1">MGKRTQSPAYVLGVGMTKFIKPRGKVDYHELGFEAGVKAMLDAHITYDDVDQGVACYCYGDSTCGQRVFYQFGLTKIPIYNVNNNCSTGSTGLAMARTMVSHGAADCVLVVGFEKMSPGSLSSKFDDRENPTGKLGEMMFATRGVTNAPGAAQMFGNAGVEYIEKYGAKAEDFAEIGRINHEHSTRNPYSQFQTEYTHEQISKSPMIHFPLTKLQCCPTSDGGAAAVVVSQAFLDARPHLKDQAILIAGQCLATDTPSVYNESSISLMGFEMTRYACQTAAAEAGINVKDVKVCELHDCFSANEMITIDALELCEPGKAHEMVRKGDITYGGKMVINPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRLVKGTDVALQHNLGLGGAVVVTVYKRADGKVSQPVTSEEVGKINQLGYNPAVEAKGFTAEQAARVLSKENRSDWAMGDTQEKVLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZB2</accession>
    <name>D4CZB2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PINIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000008">
        <property type="protein sequence ID" value="EFE45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025674.1">
        <property type="nucleotide sequence ID" value="XM_003025628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZB2"/>
    <dbReference type="GeneID" id="9581911"/>
    <dbReference type="KEGG" id="tve:TRV_00153"/>
    <dbReference type="HOGENOM" id="CLU_1312824_0_0_1"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINIT" evidence="3">
        <location>
            <begin position="44"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="210" mass="23042" checksum="3E37CC1A77B2102F" modified="2010-05-18" version="1" fragment="single">SHCADIRSRSGPTVTSALDSIITALPSGSPAAVFACITTIPDNSSSSSPKSYGYVGVDPFITRAWLMELYRPLDLQEKPVLYHSRTFDFARDSSRDTVCLRVVLTSETASRLLSNPNLRIMVYGAADNGLTHYSPSDIAFPHQVELKVNHDDVKANLRGLKNKPGTTRPADITNFIRKKVGYVNTVTMTYALTQKVVPHSSMQIAVKQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZD9</accession>
    <name>D4CZD9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_00181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000011">
        <property type="protein sequence ID" value="EFE45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025658.1">
        <property type="nucleotide sequence ID" value="XM_003025612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZD9"/>
    <dbReference type="GeneID" id="9581897"/>
    <dbReference type="KEGG" id="tve:TRV_00181"/>
    <dbReference type="HOGENOM" id="CLU_030352_2_1_1"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="443" mass="46224" checksum="80E5555CA77E26FF" modified="2010-05-18" version="1">MNPESGMSGRHRLASLALLTSVDTAIYGRSPSTLFRRCVVNCPTEAPPCPTCKEKEICTLTAKSCEACATAICVPDPLANQPSDDSGSPTGAIAGGVVGGIALLAAILLTWWFCVRRRRKNTEIWHEKTNASSVDVDGNSQRRQSAVGSIASTVLTRASNVIQIAYIPGVTNRSAPGSPDLMVPPVPPIPSAVANGQNQHFFMPGDIRDSMWSGMTDDDGKSISPSLARSSVATTIYRHNAIVSPVPAQEAYQARANIVSVKSGTSSSSPQSSPKVPAITNSQINKANAVAAKLGVSSIVARSAVAKPINVTKGGRSKTTTTTTTASSTTALSDNNSSQNTPKVTVESPERNPSTDSSSSDSSSSKNDATSTTDKNGTAKVKSRQSVQSLAVTEIDDSPDQKQSPFADPIVEEEPIPSGLTSGPTSQSNRSASPFDDKHEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY6</accession>
    <name>D4CZY6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025440.1">
        <property type="nucleotide sequence ID" value="XM_003025394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY6"/>
    <dbReference type="GeneID" id="9581666"/>
    <dbReference type="KEGG" id="tve:TRV_00380"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="345" mass="37080" checksum="6934DA13A7C097C0" modified="2010-05-18" version="1">MLSLNTPSYSAPSGYQLSELPKPVLEDSNDVIIRVHAASINPIDVKKANGMLKMAMADKFPYKIGYDCAGTVEEAGSSVSHLKAGDEIYTRLPEASRAKDVALKPPSLSFADAASIPLAAMTALQALRRYDGDLAGKTVLVPAGLGGTGMFACQLAKHAFKAGKVITTVSTSKIPKVKELLGDDTVDEIIDYTKVNPKDAIPPGTVDFLFDTVANAMEYLSLMRPKTGHIISVSTAPSGDQLQASSLMQLPHRPALPMPIKLALNAMDSIRKFRARRYGVTYSYMFLESSCKDLEELRDLVESGKLRTVVGTTASLRDLQAVREACQIVYSGRGGLGKVVIKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>D4CZY9</accession>
    <name>D4CZY9_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_00383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000020">
        <property type="protein sequence ID" value="EFE44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025443.1">
        <property type="nucleotide sequence ID" value="XM_003025397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4CZY9"/>
    <dbReference type="GeneID" id="9581669"/>
    <dbReference type="KEGG" id="tve:TRV_00383"/>
    <dbReference type="HOGENOM" id="CLU_001265_51_4_1"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="396" mass="41827" checksum="DFDE9DF3DEB00C31" modified="2010-05-18" version="1">MPFVVGLASLSASTGLFALARSLPVLVIARALQGLSAAAVWIVGLSIIADNVPTERVGEAMSYTTVALAWGSLLGPAVGGVMYEKVGFYGAFVVPMGLLAVDIAMRFAMIERKKSTQVNDDSPISKCSFASPASEFSNESYSTFTARGESSTRSISTVKRGDEEAPLLASSKQKADNVQQTEIRASATVFSLLCSPRLPLALVSIVMISLVVSSLDTTLPLFVMERFHWSSGGAGLIFMVPAIASFSTIYIAALASKIGYRIIAAAAFMLAGVSCFIMQLVQHDTTSDKVLLAGILFVLGACIATAEMIAMTQVIYAIEEHEAEFPGTFGATLPIAQAYALFNMALAAGQLLGPVATGIIRVHAGWHALMITLGVCSVLMSLPYMLIRERKTEGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>D4D074</accession>
    <name>D4D074_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000022">
        <property type="protein sequence ID" value="EFE44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025407.1">
        <property type="nucleotide sequence ID" value="XM_003025361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D074"/>
    <dbReference type="GeneID" id="9581643"/>
    <dbReference type="KEGG" id="tve:TRV_00468"/>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="576" mass="61632" checksum="55B6E9484C94AC0E" modified="2010-05-18" version="1">MAQTQSHQLPPRSFSPPASSPSPGTQQASVPGSNIPPPPKRQRLSPLPQSSQPYNSPHFAPVQLSTNGSAMHVNGMAKQAPNAPPPPGSMGPPSRPVEKATDTAELTDVLASSGIDVKEEEAFLTSGYAKPAVPVQQTHSQSISHPPRQQTSFSNSFNSIPPVGPITPSNSFSEQTPKQPGFQPAGYPYQAPVAPAPPIKSPEEISQDEQLRQDTAASRREQYHLQSAFLHTAVMEKKLEKRAQEHGVRMPMSGVFKPLPGRPTGPVEVTGPDGSSVIRRDKTILNPESALGDIISLLSLASEERLRSVIDHSVTLSRNRRVNSHGAVPPEWADLAIIQETAADDNTPTRKAEQPSTAETTVDNSTSTAKKTTTSSTLTLKSRRLIDRDESHEERRAAKRAKRNADAILGADGRLPTPGASTPNGLDRAPDIDKKISKKDIKKIDVKATGAVQHQHAIETARMQTTSLSSRFGKKGGYSWLKSSQPAVSRSGFSTPSRLSTAAAAGSAAGGNGKPGSNAASIKAIRKQFGDWREDKENGAGIQIRDLLFTLEVDGRGLKHLQKAYSKDAKEDFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0D0</accession>
    <name>D4D0D0_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000028">
        <property type="protein sequence ID" value="EFE44693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025304.1">
        <property type="nucleotide sequence ID" value="XM_003025258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0D0"/>
    <dbReference type="GeneID" id="9582913"/>
    <dbReference type="KEGG" id="tve:TRV_00525"/>
    <dbReference type="HOGENOM" id="CLU_571273_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="413" mass="46580" checksum="B194C50BE8646AE7" modified="2010-05-18" version="1">MSTTNDHHLTNSPTPWISWHGLQVRPCIAELIRTQCPPPKLLLRVERVIEVIVRMDEEAHNNDKHEAVYKAYRLFLSDGEYTIQALLKSELHVLVSSSKDDLTPGTVLDIQDYELRTANRLASKGARSGRVVFLAVARYRRAVPFKLDVQLKNLEDEHLLVKRDAAALSDEGAGDSPREEKRRQKTAERDKAMVFRAAVEDTNLLDEIEDENLKDDILGVSPCYSTAPKILSSTAMSTSMKVLTLSDLLAPRIPFPKRNYPCNVIAVISWISPQVIKRTNMPPKRDLRLIDPTIIKTVDKRRSSVTTASSLPSTSPPSITANWTVGISMSVFIDAAEFHPPVGTVAFFRGIKTHEWDGISLNAYEKDCRDKEWFITDPDRLASLGVDSSALKTWWLHVQTRWEDARKASTQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0F8</accession>
    <name>D4D0F8_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TRV_00553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000031">
        <property type="protein sequence ID" value="EFE44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025276.1">
        <property type="nucleotide sequence ID" value="XM_003025230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9580768"/>
    <dbReference type="KEGG" id="tve:TRV_00553"/>
    <dbReference type="HOGENOM" id="CLU_000022_0_0_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17648">
        <property type="entry name" value="A_NRPS_ACVS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="828"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1923"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3005"/>
            <end position="3080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFE44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="3765" mass="425437" checksum="816AE78140309A4B" modified="2010-05-18" version="1">MTIENDIKRPSNDAITLENGKALNFRKQIPSTHERMYCNGSLDKWRLCISHISERCDLSGLAKACTKYQLALTGFSDVNTHRERQTVTVDVPEEVNTALRDRYIRQGGSLRSIVLFAVHQMLRGFGNGSHTVTASISPDSEHRLSWEVSPTIVSHKNRGQTSVLEAIRNIDISNQRLQSSKNEEIEEETQPNRASRFEEVGSELEGGWMKSELFDLPVVFVKARLDHVMRLSSIDVDFPLAVLVHEGHNDGDLQLAVQFSTSLFAPETIQNFTDALKILLAEASTGPGTLVKDIDLLSAQQIQQLDVWNNTDGDYESSKRLNHLVEDAARHCPDKELLYLCHFVQPEQLIGLFLEKNELLIITILAIWKSGAAYVPIDPAFPDDRVRFVLDDTKANLLIASDAHAARLQKNITSNKDIQVIRLELLLKELTSSAAGEFHDGQNLDHLPLNSRQLAYVTYTSGTTGFPKGIFKEHTSVVNSITDLSVKYGVAGSHHETILLFSAYVFEPFVRQLLMALVNGHLLAIISDVKKYDSDYLLSLMQRHQVTYLNGTASVLQEYDFSTCPSLKRIILVGENLTAARYDSLRERFKGTILNEYGFTESAFVSALNIFKPHSKRENTSLGRPVRNVKCYILNQELKRTPIGVTGELHIGGLGISRGYLNRPDLTPFKFIPNPFQTGREKELGINRLMYKTGDLARWLPNGEVEYLGRADFQIKLRGIRIEPGEIESTLSMYPNIRTSLVVSRKLRSGGEETANEHLVGYYVCQNNVEVVPEESLLAFLETKLPRYMIPSRLVHLEYIPVNINGKADLKALPMVDLSRTAKGALNNLGHQTEIDLQKIWSDVLGIGNDSISPEDSFFRLGGHSISCIQLIARIRQQFSVIISVEDVFSMKTLSRMAAFLRKRQSEIEASCTTDIATLSRASLSFPVLSGSNSTCYLANSLQQGFIYHYLKNKEPSGTYIMQSLLRYDTELRPDVFQKAWKLTQHAFPALRLRFLWEKDVFQIIDQDQPLHFRFFSSDRDLEGLSREDKLQNLQKQDLREDYKLDAGELFRVYMIKHDDQHFSSLFSCHHAILDGWSLPLLFQHVHEEYLRLIKGGHFHFDTHIDKAYGHSQNFLQMNRDTHLEYWSGVVDQITERCDMNVLLNEQSRYKIPLANYDQVRDQRQQTLHLDCDMHLRNIHDACSERGITLHSILQFIWHTILHKYGGGSHTVTGTTISGRNLPVEGIEHSVGLYINTLPLVLDHTEYKNKSVLDAMSDVQAKVNAMNTRGHVELGRLYKSNLKHGLFDTLFVFESYPALDRVKELHHQEALHYSIQGNMEKLNYPLTAIVQDINAATIDTLTFTICYASELFDTPTILELLSMVQDTIKQISSNLTRPANSLEYLSLAQVNQLAEWNATEADFPDATLHQQFELEVDRVPSKTAIIYEDVTLTYHELNERANRMAWQLKREVDIKPDDLVALVLDKSEHMMVSILAVWKSGGAYVPIDPSYPEDRISYILQDTNAVTVIADPIYIPKVEKLTRPGVPIYPSDLATHNTSDWSSDNPPPSSISTSLAYIFYTSGTTGRPKGVMVEHHGVVNLQTSLSRIFGLRETDDEVIFSFSNYVFDHFVEQMTDALLNGQTLLVLNDTMRGDKERLYQYMEKNRVTYLSGTPSVISMYEFSRFKAHLRRVDCIGEAFSEPVFDQIRETFQGLIINGYGPTEVSITTHKRLYPFPERRTDKSIGCQIANSTSYVLDEDMKRVPIGAVGELYLGGDGVARGYHNRPDLTADRFPLNPFQTDKEKSEGRNMRLYKTGDLVRWIPGSRGEVEYLGRNDFQVKIRGVRIELGEVEAVLSSYPEVKQSVVVPKKRAQGGQTFLVGYCVSGSTISSIDIKRFMQSRLPDYMVPSRLIFVTKLPVTPSGKLDTKALPAVDESTENEVVAPRTEIERTLREIWAELLEIPLEDISIYSDFFGLGGDSLKSTRLSFMVNEFLHRTISVAELFQHRTIEALGRLIVNGIGDIQDIALITDTNKDISISPAQERVLFLHELEGGNSKGYNITKTLKLSSQTSPSLIEQALRELLSRHEALRTLLQKDAVSGIYHQKILNNNEAQSLFFINTSTVRDLDHLDQKISDASQHIFHLGEELPLRVYMFTENDVSLYLTFVIHHSNFDGWSWNIVFRELVMLYSRLQGKDSITLPKLTVQYKEFAHHHRHILIGDRFRVLSEFWRSKLENFEPLHLNTDKSRPPHFEYDGDDVNFIIGEPEVKELQKVARQCKASLYAVLLALYGLMLASYTHQTNIPVGVPVTHRTHPQFESVVGFFVNLLVVRVDVTRQGIVGLVKRVIRELVDAQLHQDMPFQEVTKLLNTEHDPSRHPLVQTVFNYESNQADTLRTKENKGGFAEYQPKQTYSAAKFDLSATVSEMGSKVMVNFNYAISLFTKSTIMGMLDTHRHLIYGVCRLTERRINDTMQLPLMPTCQGDGSHLPLLETQLAIPRDKEPVATLNKLFEAEVALASDCVAIVEGEKTITYGDLNVQANQLAWYLLSITDLKPDDHVALMLDKSISMLICILAVWKAGAAYVPLDPTFPDNRIGTTLQESKPKAVILHSKYAARFESQGMSLITIDTTENISHQSTDDVKSNVQPENLAYSIFTSGTTGKPKGVSVKQNGVINLRNGLRMRYFGNCAPGNHSVLFLSNYIFDFSLEQIALSILSGQTLIIPPEHSFASNEFYDICNSYKLSYLSGTPSLLQQIDLRKLKFLKMVTAAGEELHASQYKKMRDSFHGTIHNAYGVTETTVYNLITAFSANDGFENCLREVLPGNRIYLLSHNLQPVPLNAVGQLYLTGDCLARGYLNQPTLTTQRFIPNPFRTDEDAASGKFSHLYKTGDLARCRLDSSGNPYIEYMGRNDLQVKLRGLRIELSEVQRVMSSVPGVEDCAVIAKYMDDNPRSRVAQYLVGYYSTENPSGLEEIIIRHMKTKLPGYMIPDHLCYLRGPFPVTRTGKLDTQKLPDIDVTTGPRAVYSPPRNALQSKLCALWASVLGVERCGIDDDLFKMGGDSITSLHLVAQIHHRLSCKVTVRDLFEHRTIRKLYNNVLHNDLSGSTSEFRTEQGLVTGEAPLLPIQEWFLSKPLEKRDRWNHTFYIQTPELDVDRLSVAVQKLQDYHDAFRLRLKQKGETFVLSFPTEHQKIALRLLDVSSICERAAVNEALSEWQSGFNIENGPIGIIGYLYGYSDKTARVWFSIHHLAIDTVSWQILIRDLRNLYLDENLGSKGSSLRLWANSMSSYQGSKLEREYWDNLIAQSSQSVAALPPSTGPRLKLGRVMGADKSASLLQHAGQMEASVLAAVGLALQDVEPMCCNMVTLEGHGREEGIDSTLDVSRTMGWFTSMYPFQIPHVKEANMLAAVAEIKAEVDGVPCHGAGYGALYGYVRHPLPSVSVNYLGQLTRTSHMPDYDWNLAIGDGEYAYGLTCSPEDAKKSSSAIDITVTCIDGRVAVDVLSIWDQDKSEVLISTIERGLDHITEQLSSGSTSSTESPSCQLFTEETFTPYFEYRDPSHRQGPTLFLLPPGEGGAESYFNNIVKYLPKHSLVAFNNFYLHSKALQTFEELAEWYTDHIRRLQPHGPYHLLGWSFGGILAMEIARRLDDGSGKVIGSLLFIDTYFDVRGATEEIGMAEKTILDKIHHVYDPEPARLAHMLSRVKDVVLFKAAKPNDKYTSDEQRLLYEYYHRTRANNLDKFIPIEHVSVMPLQGNTHFSWVQDVEQVKKVCSVIENILDNMENGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>D4D0Q5</accession>
    <name>D4D0Q5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000040">
        <property type="protein sequence ID" value="EFE44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003025168.1">
        <property type="nucleotide sequence ID" value="XM_003025122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D0Q5"/>
    <dbReference type="GeneID" id="9580672"/>
    <dbReference type="KEGG" id="tve:TRV_00650"/>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="143"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1088" mass="116405" checksum="726EA754610D8A97" modified="2010-05-18" version="1" fragment="single">HLAIATFVFPYSSSGSPQSPPLAENVPLPANGSAKLIPYTPNVLSPISQDTHLAYSLPFDEIPYFLRSVQEIPDSVNDPEGIEQKKWIMKAARSSVSGSPVAMRNWFSDGWNSFVDLIKVFLSLFLLFFFFFFFSFLHAETIDIIIMALGYLSMHLTFVSLFLSLRRLGSKSWLAATVLISGGFAFLFGLLVTTALGVPINMVLLSEGLPFLVVTVGFEKSIILTKAVLERSRPQPGANPAAPNGSAAKPAAPVRSIQDAIQQAVEATGFGIVRDYLIEIAILVAGAASGIQGGLRQFCFLAAWILFFDCLLLFTFYTTILCIKLEINRIKRHIDIRKTLEEEGITHRVAEKVASTSDWPQMNFDGKGGNSKTSGATSIFGQKVRASSIPKFKFLMVGGFVLINLLNLATIPFRNRQDGLLMPVLSKVSNVLSPVPIDPFKVAENGLDVIYVSAKSQQVETLVTVLPPMKYQLEYPSAYYGNANPNVDRLLDTDYNPVLDVVGGRVLESILRSLDDPIISKWIIAALILSLILNGYLFNAARWSIKEEQSSTSSTPSESPTPAPAPVKVERKPIIKEDGTPRTLEECEQMLKDKLVTSLDDEELIELSLRGKIPGYALEKTMEHESITRLQAFTRAVKLRRAVVARNPVTSATSASVENSKLPYEGMNYTLVHGACCENVIGFLPLPLGVAGPLVIDGQSLFIPMATTEGVLVASTSRGCKAINAGGGATTVLTADGMTRGPCVSFSSVSRAGEAKLWLDSEEGQSIMKAAFNSTSRFARLQTMKTTLAGTNLYIRFKTTTGDAMGMNMISKGVEKALSVMANEAGFEDMQTISVSGNFCTDKKAAAVNWIDGRGKSVVAEAIIPANVVKSVLKSDVDSMVELNISKNLIGSAMAGALGGFNAHASNIVTALFLATGQDPAQNVESSNCITIMKKYVSPIPLHPSWRLFAITNLLSSVGGNLHISVSMPSIEVGTIGGGTILEGQGAMLDLLGVRGAHPTNPGDNSRRLARIVAAAVLAGELSLCAALAAGHLVRAHMAHNRSAAPAAPASSTSPTAPPTRSVTPVSAAVGAAKSANNLAMTAVSDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1F9</accession>
    <name>D4D1F9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TRV_00909</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000053">
        <property type="protein sequence ID" value="EFE44293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024904.1">
        <property type="nucleotide sequence ID" value="XM_003024858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1F9"/>
    <dbReference type="GeneID" id="9580395"/>
    <dbReference type="KEGG" id="tve:TRV_00909"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="313"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFE44293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="1228" mass="132067" checksum="BF9D151C92EE9EFF" modified="2010-05-18" version="1">MMADANKTTSSCCRSGSPKLPIPRINIPSEDLKTTLLVNNIHCASCVAYAKEVLHGLPDIKTVEITILAHEVTVLHGSETNTSDLVKALSDAAFEVYHADTYNESGVKVGDLDTSSSVGSTWLESGILNSPQSRKVLGRLRPVSPDTRKTHHIENCLVCREEFGAGSNQSHKGDQLEVPPPTQSGVVSAVETLRRISPQLSSPIPRSAVTPAVPPSTKDVAKPPPSTGDEIFEAQLSIGGMSCASCANAVTSEINSSSHVVSATVSLLTNSAEVAFRGPKENIEKIATQVKDIGFEASVEKVYLKKSRLEDAYVADVSIKGMTCSSCVGSVTRALDACPYITNATIHLLGNSGKIEFQGKENLEDIISRIDDLGFEAAIVDCKPIGNNSSIANEEVKRRTVQIKVEGMFCPHCPQKILGALRGIPDAAVTIIEELTLEEPILTLSYTPNSPTLTIRNIIATIDGANEVFTASLYHPPTIEDRSRAMQMHEQKRLLLRLLFTFIVGIPEFLIVPKSNSIRRYLEEPMWIGSVSRAEWALFILTTPVMFFGTDVFHARAFKEIRALWRPGSRVPILRRFYRFGSMNMLISAGAMVAYFASLAVLILKSRIPDKGREPGEIATYFDTVVFLTLFILVGLALEAYSKAKTGDAVAMLGKLRPSDAILVLDHVLSGQPDPNNTSIQRVPVDLLDIGDIVVIPHGGSPPADGNITGTTPTTTKSKGDKVFSGSVNVGRPVSIEITDLGSTSMLDQIVAVVREGQAKRAPVERIADAITGYFVPMITLIAILTFIVWLSLGQSGVLPPDYLDSEQGGWPFWSLQFAIAVFVVACPCGLALAAPTALFVGGGLAAKRGILVRGGGEAFQEASRLDSIVFDKTGTLTEGGDLKVSDHEVLITDENDLQIAWALGKALEESSTHPIARAIVEFCSDKTAVTVKQTSVEEIPGHGMKGSFTVRLDGNDQALEYEASIGNQRLVDLLCGEDPDLYFLPNILSRYHSAGKSSAVLSIRKANGTARFAPAIIFATSDPLRHEAAQVVSQLQARNIDIHMCTGDNAVTAHAVASVLGVPRSNVIANVLPSQKAEYIKKVQNNELGIKAQLCTKSKAKTRRNIVAFVGDGTNDSPALAAADVSIAMASGSDVAVNTAGFILLNSDLNTILDLCKLSRRVFNRVRWNFLWAAIYNVSLIPVAAGVFYPIVSGHTVRDGIVINNHWRLDPAWAALAMALSSVSVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1Q1</accession>
    <name>D4D1Q1_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TRV_00994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000057">
        <property type="protein sequence ID" value="EFE44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024829.1">
        <property type="nucleotide sequence ID" value="XM_003024783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1Q1"/>
    <dbReference type="GeneID" id="9580307"/>
    <dbReference type="KEGG" id="tve:TRV_00994"/>
    <dbReference type="HOGENOM" id="CLU_015384_0_0_1"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFE44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="664" mass="70797" checksum="F2B237D4BC31EFF6" modified="2010-05-18" version="1">MSNDTNLLDASNSWTSISAHGNGSGSATSTVRSRTRRIIPSFDGADDDGQPGGLSGNTSQRSLHTNGGTSRSSPYSSRGVSPIPSKRLPRTGGGGTGLHDGQSPSTVRGRGAGFGGMTREDTRGVGKSNGFATDFLESPWSSLQGLASNIIGSGSALINGEPVKPFGPRSRSVGGELARNRRPGPTSWGPPRSIIGEANPDAQRERQELIQAKKREALLQANGDSFPDSRGNYKRRDSGDGFERSTGTSTPAQEEGDALVYIHPVQSSDTLTGVSIRYGCELAVLRKSNGFWPSDSIQSRKSIVLPVESCTLKGLPIPEEEVRKQNDDTKEDDPDHDTSSLVPDSNASSSCDFGYGDTQLDLDTSNTDNESTSGSPWTHHSWVKLDGFPSPVEIGRLPRRSLGFFPRARRKSQLRLSPYKDNPGPSSSTQDLPGLQSPSRKQRDSTSSRRISDISRDGSMTGTRSPRYSSSMQHRRQRSITLSGPGGVGTLENATCPGPPIDKFTTFVNSHLPTLTIKPAPNDAAPTFASLQNLDRASLDSSDSAVFSSSSTAGLENVGGAIEGWFRKVATRAKAGINEIQQQQQPLSQRLANLGLAGASGDLIELNDAPESIKPSHSPSTIFMDGPSETQATSSSRSDTPAMRRSAFNNDPSSHADNRQKKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>D4D1X2</accession>
    <name>D4D1X2_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACYE01000060">
        <property type="protein sequence ID" value="EFE44181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024792.1">
        <property type="nucleotide sequence ID" value="XM_003024746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D1X2"/>
    <dbReference type="GeneID" id="9580282"/>
    <dbReference type="KEGG" id="tve:TRV_01074"/>
    <dbReference type="HOGENOM" id="CLU_030276_0_0_1"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056102" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="440" mass="47377" checksum="C3830DCCC863CA8C" modified="2010-05-18" version="1" fragment="single">KMRYSLFFGAALAASVSTVAAEAGCTNDGGNWYCSAVDLITYSGFSTSGTYDLVTSMSGGKCGSEKHEYSGVFGPLGEELSIHLRGPMQLFSMAVYNRGSEKPKRELKPSIHERRHGHSHQRFHEKRAVGDTVVATIDGQVVSWINQYNGGAPAAPTPAPGAPGIKDPQVKSNGYKGGDKPKDPEPHGPVNVGPGDWRRVALVDTDRKEAEGVSFLNNDGGWDKGVEQAFGAALKKLGLDDDFFGMGEGPNFPKDSTIPDGKELIIMSDKSCEDGSCGFTRPGADAFHGFGGEDKIFLFRVAMPVTGSQASSIYDPKDMPAIWLLNARIPRTSQYPMDPACSCWKSGCGEFDVLEVLAPGDKRCKSTYHTEQSKSGGSSYYFDRPEEPITVAVVFNSGDGTLYVKTLKDGFDKFPETLNPEDVKKLCADDGKTNNFALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>D4D217</accession>
    <name>D4D217_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="ACYE01000062">
        <property type="protein sequence ID" value="EFE44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024712.1">
        <property type="nucleotide sequence ID" value="XM_003024666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D217"/>
    <dbReference type="GeneID" id="9582887"/>
    <dbReference type="KEGG" id="tve:TRV_01119"/>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="337" mass="39446" checksum="1650760BB50B3DD9" modified="2010-05-18" version="1">MARVYADVNQKMPKTYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGVNVVNYQKCVVKVLKPVKKRKIKREIKILQNLSGGPNVVALLDVVRDSQSKTPSLVFEYVNNTDFRTLYPRLADYDVRYYIYELLKALDFCHSKGIMHRDVKPHNVMIDHERRKLRLIDWGLAEFYHQGMEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGSSNADQLVKIAKVLGTDDLFDYLDKYNIELDPQYDEILQRYQRRPWNSFISAENQRFISSDAIDFLDKLLRYDHTARLTAQEAMAHPYFSPVRHASSNAQSNTAAASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>D4D261</accession>
    <name>D4D261_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000063">
        <property type="protein sequence ID" value="EFE44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024700.1">
        <property type="nucleotide sequence ID" value="XM_003024654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D261"/>
    <dbReference type="GeneID" id="9582875"/>
    <dbReference type="KEGG" id="tve:TRV_01163"/>
    <dbReference type="HOGENOM" id="CLU_029043_1_0_1"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="417" mass="46770" checksum="9C0A363427356B82" modified="2010-05-18" version="1">MPGWFPTERFDTAGWRLEGVGLLAVLGESSVADQAQPLTASKLSLLPRLIPAPQALLRATRPVRLPSPPAVVCGVHSGTLVHELNYFPNIIHPIADLKPYQVVVYEISWAEKRTKYEKSQSIKLEKLIMPEGLRSKRPVSVPPPHKHGNKYAITPNKWSPLSLITISSFLMTACAFAWALVIRDGTAAVAIFLMSMVSTLNGFAFYWKPHLAVRPSSAVVPRGDIIIRTREGAFIVVRCTEELARELYTGTEECNYSLSEQWARVLVGIGTFLIMFAVVLLGNCEWTMQAVVSAIYMLMNAMYWGSSLMPKSWIWDMSRYDWKDVTPDNVKAAHEIGSDGAQPSFTRTLWYAIHATEEINWVIVSGAVPQTQAWENWLELAYANRTDPDWDAVGEKDRLMAEARRSQLVPSRKDHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2B8</accession>
    <name>D4D2B8_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000066">
        <property type="protein sequence ID" value="EFE43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024605.1">
        <property type="nucleotide sequence ID" value="XM_003024559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2B8"/>
    <dbReference type="GeneID" id="9579929"/>
    <dbReference type="KEGG" id="tve:TRV_01221"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="218" mass="23478" checksum="C0A354E961F8C380" modified="2010-05-18" version="1">MVANDSKTLRIGVLLTHSVQLLDLAAVDLFGMMSKDYISEVDVLPPEIASLGLPVDINYIGIQPNCAGTFIRCTANIGIRLNASIHDTSVSTDSLDILVIPGPDPKYVPDESVLAFVKAHHDAGNDILSICTGSYVAGYAGILDHKNVTGPRGLISDLEVKFPNVKKWDTTRRVVKDGNVWTSGMILPLSDEPNMSPWFGLSVSNPHLNKDQLSNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2D5</accession>
    <name>D4D2D5_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TRV_01240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HKI 0517</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ACYE01000067">
        <property type="protein sequence ID" value="EFE43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024601.1">
        <property type="nucleotide sequence ID" value="XM_003024555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2D5"/>
    <dbReference type="GeneID" id="9579924"/>
    <dbReference type="KEGG" id="tve:TRV_01240"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFE43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="463" mass="51638" checksum="2834B112AE08D94D" modified="2010-05-18" version="1">MASAQKATKLWGGRFSGELDPLMVTYNESINFDKAFYAQDIKGSIAFARANVGTGILTQEEFAAIEKGLNQVLQEWKDDKFVIQHGVDEDIHTANERRLGEIIGKDIAGKLHTGRSRNDQVATDLRMWLRDELREAEKFLVELLTILTDRAALDIDYLMPGYTHLQRGQPVRWSHWMLSYGSAFLGDLERLREVIKHVNKCPLGCGALAGNAFGIDRVAMAEELGFEGLILNSMAGVGDRDFILEALQWASTLMLHLSRWSEDLIIHSTTEFGFVRLSDAYTTGSSLMPQKKNCDSLELLRGKSARLFGSMAGLTMTIKGIPSTYNKDLQESVQPMIESMKTIKDSILIATRVLATLTVFPEKMLAALSPDMLATDLAEYLVRKGVPFRETHHISGRVVALAEKENVPMDKLTLAQFKSVDERLGDDVLEVFNYEKSVELKSAIGGTSRSAVLKQIETMRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2D6</accession>
    <name>D4D2D6_TRIVH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TRV_01241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000068">
        <property type="protein sequence ID" value="EFE43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024595.1">
        <property type="nucleotide sequence ID" value="XM_003024549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2D6"/>
    <dbReference type="GeneID" id="9579922"/>
    <dbReference type="KEGG" id="tve:TRV_01241"/>
    <dbReference type="HOGENOM" id="CLU_610016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFE43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="449" mass="49994" checksum="6DFFEF0A97557268" modified="2010-05-18" version="1">MEDAGDDDGGSVASDIDCGGSAWEKAGDKRLISWGGLRTLGDTAKLELSRDEMRRSSWSFHTVLRRASGRARQQSRAGSHRSLSLETLELNPALSLPPFFFFAFWLSKDQQLCYSGTTMVDSVRSSVDHRPSLESSPRSSSLQVTAREPCLVWLHLSPRSPRSLRNNTTTSPGGPWLPSQRLSLPAPSPPFLAEYRSTQWERGREREGGGWPTIVVCGNSRLQMAVWLPMEDPAAIEIAASTGYTLRADDEEEEEGIMVIFVFESPVSATVTMTGWRVQTLCCRLEDSVISHSSQGRLLRHDDEITNGVKKKRRYVDIPFLLGLSTEGSKPTGRRKKVISIDLLEYSTSAYVFIISYPGYAPLADGVIISPGQQRCVHRIPDGFICPLARSVKVGRGMLFPFERRAAAFYRTAGESTRHLLTLFTLIMIILLQPARQLKDKIRRTASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2T6</accession>
    <name>D4D2T6_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TRV_01392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000077">
        <property type="protein sequence ID" value="EFE43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024429.1">
        <property type="nucleotide sequence ID" value="XM_003024383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2T6"/>
    <dbReference type="GeneID" id="9579651"/>
    <dbReference type="KEGG" id="tve:TRV_01392"/>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="96"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFE43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <sequence length="542" mass="60225" checksum="0EB05197B437A70D" modified="2010-05-18" version="1">MAADTEKEKEKTKIDAGLASLNHYQRKLPAWRYKLRQRTLPLVRWETPYLAWLQERIRTPSLDSWFAITANLGTHTFYMVMLPVLFWTGHTGIGRAVVHLLAAGVFFSGFLKDLLCLPRPLSPPLQRITMSGSAALEYGFPSTHSTNAVSIVVYALHALRSQSDLAPLASTLLQTGLYVYVTSIVIGRLYCGMHGFLDVVVGSMLGALLGFVQCVYGPKFDEYLFTGSIKEVLVIIAVIIALVRVHPEPADSCPCFDDSVAFAGVFAGVELGNWHFASTKYSLSVPTPATVPFDLQRMGWLKTVLRIIIGVACVVVWREVMKPTLLRILPPLFRVIERLGLSLPRRFFKRATEYTRIPGQLKYDDVMPNVSDIPSMLTSIRHPRRRAVSIGPQSEADAYEAIAYRQERRRASAASENGRPPTPLRENVKSPTLRPTTRSKRTASNVSDTQSPSRSLHDYENMMGSGAQIYEEGNGQSVDALANGNGKVTNNDEDDEKDMFLRITPPRVRYDVEVVTKLIVYSGIGLVAVDGSPILFHLLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>D4D2X9</accession>
    <name>D4D2X9_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TRV_01435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HKI 0517</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000078">
        <property type="protein sequence ID" value="EFE43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024369.1">
        <property type="nucleotide sequence ID" value="XM_003024323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D2X9"/>
    <dbReference type="GeneID" id="9579508"/>
    <dbReference type="KEGG" id="tve:TRV_01435"/>
    <dbReference type="HOGENOM" id="CLU_040321_0_0_1"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003056131" description="Vacuolar membrane protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFE43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39915" checksum="595870013CB9F716" modified="2010-05-18" version="1">MAAGHDTLTLRHTTSTIMLLAATMTSVSSATRTSTVTATATATATATATATATVTGSPNAPGDAGNGKCELLGPFALVIQVSLGALALLVLVYKRWKERPQRPVKVWAFDVSKQVFGSSMLHLVNLLASMLSAGQISPDAKQTNPCSYYLLNLGIDYTFTNMKQTTLGIPILILILRVLNHAALYTPLANPPESIESGHYGRPPKVLWWFKQSMIYFFGLVLMKICVLCIIYWLPFIVLVGDWALRWTEGNTAVQIFFVMLLFPVIMNAVQYYIIDIFIKKRASEHDPLHPHEEDHDFDDTASINSDRHRRSALLAGLDDEDDYPASDDEVLNSAPVIFSDDESSSKPATSKATSHKPPPLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-05-18" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>D4D389</accession>
    <name>D4D389_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SH3 and Ded_cyto domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TRV_01548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HKI 0517</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACYE01000081">
        <property type="protein sequence ID" value="EFE43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003024299.1">
        <property type="nucleotide sequence ID" value="XM_003024253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9579419"/>
    <dbReference type="KEGG" id="tve:TRV_01548"/>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="10">
        <location>
            <begin position="629"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="11">
        <location>
            <begin position="1454"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1888"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1931"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2007"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2052"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2091"/>
            <end position="2103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFE43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2139" mass="237450" checksum="16BC4DFD86D1F370" modified="2010-05-18" version="1">MPWKPLPRIAFAVAVYPFQPSSPADLPLELGDELYIIEQGGASGEWYRGYLVAPPSLLAGLTSVRGQTLEARVFSGIFPKNCVEVREVLGDADEANDRPRDSPGVVVNGDSRSIAAASPENGQPGDIKPTSRGLAPEVKTARKLSPLTILKLEEDATKRRSGMSMQAPAVASLTPTPTPPVPPPHAPPPRRDSADAKPAAPVPMLKIGDETPTSMSEPLVDEIASCLREWHSTNIHGLLLGRQYATLESMSNIVLELDLARRQLLHNVLTAQERKTLREETVWNLVRGNKMLSGDVIVRDPAQRGRLLTGDDSAIELTKLQSEMSMLDGKITHPSDTVSLHHLLFELDAVTGTISSPIVLAVSLCLQSPAGDVKPLSETYALDVPSAESFSSLAVSGKLKTLFTELSAADIGEISGADSKLFLVVKVLNWEAPRTVPFLSKSHSSSGSSTSRAGAQFSNAGKGSLRGRRSMMWGPKGSKGGQPVDPAAKEATNNAPPRSSDGTDKEKQTAAPPKKKDPVCRMIGVGAIEVGPLVKAGKSTEQVFTIWSPLNENEEEDANTDGFHEIIRSLIYSPTGRYTRSYQAARLHTHLYPFTSTDADALVKKNPTLLHSVTQTRRIGFPGAPTKPRSDIYVTLSRANISRDALLSHPVHGQVPVPQSTGLRNIQLTLEVRNSSGARVEKCICPSSNATPVIAWRTTVTERLSSWNQTIRLSIPADQVPGSHLIMSIADAPEFPFALSWMPLWDQQAFIRDGPHSLLLHAYDKSTSSIENGKGAYLSLPWSALGKNECTKDEAVTGPMATLIVETDLCSTEYSQDQVMLGLLNWKEKPASELLELLRRLVFVPEIEIVKQLSNVFDALFGIIVEHSGHDEFEDLVFTDIVTVLGILHDRRFNLGPLVDQYAKEQFNFPFATPCLIRSYCRLLQATPDSQQSRNLRAAFKVGRHILKFIINAREQQKAKEEGIGITNIQLTFNRNLTFIFKSVEALMQNPAPILVGSKTLVVQHFHTWLPELSSALTKDEIIDIALSFMDSCKDVKGMLILYKLVLIQNYFQLSLFAEQKERKMLYARCAEWLDPYWGAVSEVTDQYRDQVRLCSSIIAEQLKHPEPELFEYMPKVVASYCAIAADGVEESNWLSLLFSKSFPFQLKQSKTSQKFDEALVELSALTAALSAIPNPVELVMEPDEMAIFLSRAFTTHISILDCVPYPASWLSLRIYHHRSVVKSLEHWSAMLIKSFLPPVEEADTFDMELWRLFFATILKLVSSDALALETFPEQKRRAVWKIAGDVREHGAELLRTTWKAIGWETTPEERDRFGLDRLGGYQVQYVPSLVPPIIELCLSVHEGPRRVAVEILQTMLVSEWQLNEDLAMIEAEIISSLDETFKTRNFSESITQKLFMTELMELFDSKSETLDPELMVALKELVATVDELLDLLAAAHSGNISESLNTLKLMEFMKDMDKEDIFIRYVHELAKGQVAARNFTEAGLALQFHADLYNWDSSQLLPALAIPEFPEQSAFDRKEALYFQIIQHFEDGKAWAHALACYRELADQYEHTTLDFAKLSRTQTSMARIYDSIVRDDIQVARYFRVTFKGLGFPATVRDKQYIFEGHPTDRLASFTDRLQKEYPAAQLITSGEIEDLEGQFLRVSAVSIHRDMNHPVYQRTKVPQSVRDHLLTSVPAQFSVTSKKHLNGNNVKKQWVEKTIYTVAEPFPNILRRSEIVATDEVSLTPLQTAIERTWRKTQELIILERRATLNPDANLSAVAELIRQLVDVEAQPSTCAALYRQFLQEDYDMDVPTENGDVDGPVHPNHPLRNALATALIEHAVAIKRCLMLFNLRPSYQSDQIELVRQFESIFSHELATFIPVAGQFQEDTLPTFNRFDPFANTQAPRVQDIQNDGPPPKPSLSRSLSNAVSEAPSRRLSLNPFRRSHHGPSNSVTTITQETIRSNSSLRNQSISEGMKLNGTTMVNEPLRAPTSASNKADMNERKGSLSAQSKTDGSQKRRSWFGNGSTTSSNNGNATEARPNCTTTPSTEDIKTTQQRIIERAKAARKQNGTTYSTIPQTRPSTNGSNRTGISARSGGQHSPISPLTNNSGGSSNMSASAVRDSVMRRLSLLKSGRKASRANFREGGAMGGAVKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>D4D445</accession>
    <name>EASC_TRIVH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Catalase easC</fullName>
            <ecNumber evidence="6">1.11.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ergot alkaloid synthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">easC</name>
        <name type="ORF">TRV_01859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichophyton verrucosum (strain HKI 0517)</name>
        <dbReference type="NCBI Taxonomy" id="663202"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Arthrodermataceae</taxon>
            <taxon>Trichophyton</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Genome Biol." volume="12" first="R7.1" last="R7.16">
            <title>Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.</title>
            <authorList>
                <person name="Burmester A."/>
                <person name="Shelest E."/>
                <person name="Gloeckner G."/>
                <person name="Heddergott C."/>
                <person name="Schindler S."/>
                <person name="Staib P."/>
                <person name="Heidel A."/>
                <person name="Felder M."/>
                <person name="Petzold A."/>
                <person name="Szafranski K."/>
                <person name="Feuermann M."/>
                <person name="Pedruzzi I."/>
                <person name="Priebe S."/>
                <person name="Groth M."/>
                <person name="Winkler R."/>
                <person name="Li W."/>
                <person name="Kniemeyer O."/>
                <person name="Schroeckh V."/>
                <person name="Hertweck C."/>
                <person name="Hube B."/>
                <person name="White T.C."/>
                <person name="Platzer M."/>
                <person name="Guthke R."/>
                <person name="Heitman J."/>
                <person name="Woestemeyer J."/>
                <person name="Zipfel P.F."/>
                <person name="Monod M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21247460"/>
            <dbReference type="DOI" id="10.1186/gb-2011-12-1-r7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>HKI 0517</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Microbiology" volume="158" first="1634" last="1644">
            <title>Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.</title>
            <authorList>
                <person name="Wallwey C."/>
                <person name="Heddergott C."/>
                <person name="Xie X."/>
                <person name="Brakhage A.A."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="22403186"/>
            <dbReference type="DOI" id="10.1099/mic.0.056796-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:22403186). DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:22403186). The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (PubMed:22403186). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:22403186). Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae (PubMed:22403186). However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet (PubMed:22403186).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACYE01000098">
        <property type="protein sequence ID" value="EFE43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003023997.1">
        <property type="nucleotide sequence ID" value="XM_003023951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D4D445"/>
    <dbReference type="SMR" id="D4D445"/>
    <dbReference type="GeneID" id="9582690"/>
    <dbReference type="KEGG" id="tve:TRV_01859"/>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000008383">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0376">Hydrogen peroxide</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000439125" description="Catalase easC">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
       
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